Guided By:Dr.(Mrs.) A. M. AVACHAT

Presented By:RESHMA UKALE

ANIKET VAIDHYA M. Pharm, Sem- II (Pharmaceutics)

Roll.no:521 & 522

Sinhgad College of Pharmacy Vadgaon Bk, Pune (41)

Seminar on

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(2016)16/ 03 /2016

WOUND HEALING TECHNOLOGY

WOUND

It is a injury caused by external force and it can involve any tissue or organ

A wound is a break in the integrity of the skin or tissues often which may be associated with disruption of the structure and function.

A cut or break in the continuity of any tissue, caused by injury or operation.

CLASSIFICATION OF WOUND:

1. Clean Wound

2. Colonized Wound

3. Contaminated Wound

4. Infected Wound

HEALING

Healing is the body’s response to injury in an attempt to restore normal structure and function

Response of an organism to a physical disruption of a tissue/organ with an aim to repair or reconstitute the defect and to re-establish homeostasis.

During healing, a complex cascade of cellular events occur to achieve resurfacing, reconstitution and restoration of tensile strength of injured tissue.

The progress of healing involves two distinct processes:

REGENERATION

REPAIR

1. Inflammatory phase: It can be broken down into furthera) Clot formationb) Early inflammationc) Late inflammation

2.Proliferative phase

3.Maturation phase

PHASES OF WOUND HEALING:

PHASES OF WOUND HEALING:

a) Clot formation:

Blood vessel contraction initiated by platelet degranulation of serotonin, which acts on endothelial cell and increases the permeability of the vessel, allowing a protein rich exudate to enter the wound site

A platelet plug formation

Activation of extrinsic and intrinsic clotting mechanism

INFLAMMATORY PHASE

Characterized by formation of granulation tissue in the wound.

2 key cell types are present in this phase: a) fibroblasts

b) endothelial cells

PROLIFERATIVE PHASE:

Begins 5 to 7 days after injury.

There is conversion of granulation tissue to fibrous connective tissue and decrease parallelism of collagen to the plane of the wound.

Maturation of the epithelial layer quickly follows formation of the epithelial seal.

MATURATION PHASE:

WOUND HEALING TECHNOLOGY

1. X Stat

2. Self Healing Nanogel

3. Vetigel

4. Digital Bandage

X STAT

XStat® is applied into the wound cavity using a lightweight applicator

The applicator is available in a 30mm diameter size.

XStat® is not indicated for use in other parts of the body such as the thorax, pleural cavity, abdomen or retroperitoneal space

Is a syringe-like device that injects small, expandable, haemostatic sponges designed to stop high-flow arterial bleeding from non-compressible junctional wounds

The sponges are coated with a haemostatic agent and have a radiopaque marker attached to aid removal later using X-ray imaging.

The sponges which are containing a cellulose that have an absorbent coating

X STAT MECHANISM

SELF HEALING NANOGEL:

Nanotechnology have developed a nanogel that can accelerate the healing of burn wounds to minimize the risk of infection and scaring

The peptide hydrogels can promote skin regeneration by acting as a scaffold for skin cells to grow

When water is added, the peptide self assembled into nanofibers that entrap water to form fibrous gel which resembles the extracellular matrix

Gel which is a porous and rich in moisture acts as a scaffold to support the growth of skin cells, thereby promoting skin regeneration

Ultrashot peptide are nonimmunogenic and non toxic

Invented by Joe Landolina Student of New York University year 2015Company U.S. firm Suneris.

Veti-gel is a veterinary product, a plant-derived gel that is claimed to quickly stop traumatic bleeding on external and internal wounds.

waiting on FDA approval for human tests

VETIGEL:

they participate in the activation of muscle tissue, blood vessels or even bone structures

Composition

The gel is made of plant-derived polymers.

VetiGel is an algae-based polymer in the form of a gel & extracellular matrix or ECM.ECM are usually proteins produced by cells and they are used as supporting items – hence the name matrix

VETIGEL:

Action of vetigel:

Once it hits the damaged tissue, whether its open skin or soft organ like livers , kidneys, spleens.

Gel is instantly forms a mesh like structure

injected into wound site , the gel can form a clot within 12 sec and permanently heal the wound within min.

Fibrin helps repair tissue over the long term

Vetigel not only to work fast in sealing leaks, but to actually heal the skin within few min of application

The gels contain algae based polymers that acts as sealent, sealing the wound allows platelets to accumulate at the site of injury to form a mesh

Mesh acts as a scaffold to helps the body produce fibrin at the wound surface

VETIGEL 100% bio-compatible and should not create problems regarding our organism.

extracellular matrix (ECM) are already commonly used in laboratories, to create synthetic tissues for instance, and they are considered as relatively harmless.

CONT……

Digital Bandage:

Wireless specialist has created a high tech bandage that can be used for checkings a patient vital signs

The device work by attaching it to a patients chest, enabling it to take readings every two min

Different factors the gadget can monitor include heart rate, temperature and respiration

Its like a adhesive patch

The key advantage of the system is the frequency of the data send automatically from the patch

Electronic bandages that can speed up healing

They recruited 40 volunteers who had two identical wounds created on their inner arms using a punch biopsy

One was allowed to heal naturally, while the other was treated with electric current delivered in pulses over a period of two weeks

Resulting increase in vascular growth within a treated wound the grew smaller faster than untreated one

Now a days develop a bandage that has the capability to monitor the status of a wound and administer medicine if necessary

In this type of bandages, incorporating in to the bandage electronic sensors to monitor a wound status

Researchers develop the combination of bandage and medical device are called flexible bioelectronics

Use of these smart bandage would be intended for serious wound, such as a burn injuries or chronic wound such as a diabetic foot ulcers

SMART BANDAGE

STREACHABLE HYDROGEABLE ELECTRONICS

CONCLUSION

Now a days The field of wound care is ever expanding with advances in technology. . Current wound healing products and modalities increase the armamentarium of the wound practitioner to address all aspects of wound care.

Joshua Crist, M.S.E. ,Xstat-FDA Overview, Biomedical engineer, Centre for devices and radiological health, Hemostatic product workshop, September 3,4 2014

Xstat Hemostatic device for noncompressible junctional haemorrhage, By Horizon scanning research and intelligence centre, June 2015

Patrick S. Murphy and gregory R.D.Evans, aesthetic and plastic surgery institute, Advances in wound healing: A Review of Current Wound Healing Product

Sara UD Din and Ardeshir Bayat, Electrical stimulation and cutaneous wound healing: A Review of Clinical Evidence Healthcare ISSN 2227-9032

Asian Scientist Magazine, Self Assembling Peptide Nanogel for burns, May 26,2014

REFERENCES

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