RetinaLyze System Switzerland GmbH

Worlds first accurate glaucoma screening algorithm

Automated lesion detection software

Our current system

RetinaLyze, an automated screening tool for DR and AMD

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Online software, which screens automatically (not a diagnosis) and delivers easily understandable results

Cooperates with ophthalmologists by referring to an ophthalmologist for further examination, if needed

Results within 30 seconds

Seamless integration with fundus cameras

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Screening for glaucoma today

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TONOMETRY PERIMETRY OCT

Tonometry

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Perimetry and OCT

Time consuming (SITA fast = 5-8 minutes)

Customer fatigue

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Expensive for screening purposes

How we normally assess the optic nerve disc

AAO guidelines:

• Generalized enlargement of the cup

• Focal enlargement of the cup

• Superficial splinter hemorrhage

• Loss of nerve fiber layer

• Translucency of the neuroretinal rim

• Development of vessel overpass

• Asymmetry of cupping between the patient’s eyes

• Peripapillary atrophy (beta zone)

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The new way of looking at the optic nerve disc

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RetinaLyze Glaucoma

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Instant results

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Results in 30 seconds

Comparision with the other methods

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RetinaLyze Glaucoma GDF

RetinaLyze Glaucoma VERT. C/D

RetinaLyze Glaucoma AREA C/D

New version

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New discriminant index between normality and glaucoma

New index has a sensitivity and specificity much higher than the previous one

7 different cameras

Superior to the results we have obtained with OCT in the same patient groups

How to use RetinaLyze GlaucomaFrom image to result

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From image to result in under 1 minute

Capture imageTransfer image to

RetinaLyzeInitiate analysis Get result

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Availability

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RetinaLyze Glaucoma will be generally available:

Q2 2018

BUT WHY SHOULD OPTOMETRISTS SCREEN FOR EYE-DISEASES?

0,9 billion diabetics

207.000

ophthalmologists

209.000

ophthalmologists

205000

207000

209000

211000

213000

215000

217000

219000

221000

223000

225000

2015 2025500

700

900

1100

1300

1500

1700

1900

No

. o

f D

iab

ete

s p

ati

en

ts in

mill

ion

s

Gap in the no. of diabetics and ophthalmologists the next 10 years

Alle diabetes patients must be screened every year for DR. Ophthalmologists perform the screening today.

17. januar 2018

Sources: International Council of Ophthalmology (ICOPH) - http://www.icoph.org/ and International Diabetes Federation (IDF) - http://www.diabetesatlas.org/

1,8 billion diabetics

Projected increases in AMD and Glaucoma cases

196000000 million

288000000 million

76000000 million

111800000 million

2020 2040

AMD

Glaukom

17. januar 2018

Source: https://www.ncbi.nlm.nih.gov/pubmed/25104651 and https://www.ncbi.nlm.nih.gov/pubmed/24974815

Why should retail optometrists screen for eye diseases?

3 of the biggest causes for preventable blindness are DR, AMD and Glaucoma.

At least 90% of these incidents develop very slowly.

The patient will not notice any symptoms in the early stages.

The earlier the disease is caught, the more vision can be saved and the cheaper it is to

provide treatment.

Optometrists have the manpower and can provide accessibility for the clients!

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What is in it for the optometrist?

• Attraction of new customers with novel services (add-on for your eye-test), increasing

revenue

• Gain long-term relationships with your customers by making eye-health a part of your

business

• Remove focus from pricing and regain professional brand

• Annual screenings allows for more regular contact with existing customers, increasing

revenue

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How do I cooperate with the ophthalmologists?

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2. RetinaLyze-screening

RetinaLyze automatically screens the images and gives results for DR, AMD and/or

Glaucoma.

Red resultsCan be red results or patients with symptoms.

4. Local ophthalmologist diagnoses

If necessary, the operator refers the patient to the local ophthalmologist,

who diagnoses and treats the patient.

Green or yellow resultsPatient is invited for a screening again

withing 3-12 months.

1. Capture fundus images

An operator captures fundus images of their patients.

3. Tele-medicine assessment

An eye-specialist asseses the image online and gives the

operator guidelines for the next steps.

The advantages of this process

Helps ophthalmologists sort out people who don’t need their attention

Only patients with suspected eye conditions are assessed with telemedicine (cuts costs and doesn’t waste

anyone’s time)

Necessary information for the referral to the local ophthalmologist is checked via telemedicine before referral

The severity of the issue is assessed to make sure that no-one is rushed to the local ophthalmologist without

need.

Increases cooperation between ophthalmologist and optometrist.

Optometrists can get help and guidance immediately, if there is a pressing issue or doubt.

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Does this process actually work?

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Out of over 635.200 screenings we found 5.871 people with potential undiagnosed illnesses (an excerpt):

Total number of clients screened: 134.489

2.375 AMD 754 Diabetic Retinopathy1.013 Glaucoma 267 Pre-retinal Fibrosis191 Hemorrhages156 Chorioretinitis sequelae91 Arterial Hypertension63 Pseudoforamen

71 Suspected tumor9 Cataract41 Exudate51 Papilloedema37 Venous Thrombosis15 Artery embolism22 Oedema8 Amotio Retinae

What is Glaucoma?A disease that damages your eye’s optic nerve

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A group of diseases which attack the eye’s optic nerve

There are several types of glaucoma

A liquid called aqueous humor is produced continuously in the

eye. If the liquid cannot escape again, the pressure builds and

damages the optic nerve

Symptoms develop over time or can be very acute

Often no symptoms in the beginning, but then often blurred or

decreased vision with halos

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In a healthy eye, excess fluid leaves the eye through the drainage angle, keeping pressure stable.

Glaucoma vision example

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Diagnosis and treatment

Tension (IOP) and cup/disk ratio have been indicators when performing a screening

Visual Field Analysis, Cornea Thickness (CCT) measurement, Fundus images, Inspection of eye’s

drainage canal is necessary for diagnosis

Treatment options:

Medication, Laser surgery, Operating room surgery to relieve pressure

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