workshop sessions day 1（october 28[sun]） · akatsuki saito 1），joao i mamede2

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Virus Research Insight and Serendipity

WORKSHOP SESSIONS DAY 1（October 28［Sun］）

WORKSHOP SESSIONS DAY 1（October 28［Sun］）WorkshopRoom 1（1F Terrsa Hall） Day 1　October 28 [Sun]　13：00～13：36

Virus entry 1Chairs：Zene Matsuda（ Research Center for Asian Infectious Diseases, The Institute of Medical Science, The University

of Tokyo）Yosuke Maeda（ Faculty of Life Sciences, Department of Microbiology, Kumamoto University）

W1-1-01 Triterpene derivative NAT-078 as a novel bifunctional HIV-1 entry inhibitorShigeyoshi Harada1），Tetsuo Narumi2），Yuta Hikichi1,3），Tetsuro Matano1,3），Kazuhisa Yoshimura1）

1）AIDS Research Center, National Institute of Infectious Diseases，2）Graduate School of Science and Technology, Shizuoka University，3）Institute of Medical Science, University of Tokyo

W1-1-02 Mutations in the gp41 ectodomain can contribute to HIV-1 resistance to small-molecule fusion inhibitorsYuta Hikichi1,2），Shigeyoshi Harada1），Tetsuo Narumi3），Tetsuro Matano1,2），Kazuhisa Yoshimura1）

1）AIDS Research Center, National Institute of Infectious Diseases，2）Institute of Medical Science, University of Tokyo，3）Graduate School of Science and Technology, Shizuoka University

W1-1-03 Human mannose receptor 1 attenuates HIV-1 infectivity in a virus isolate-specific mannerSayaka Sukegawa1,2,3），Yasumasa Iwatani1），Klaus Strebel2）

1）Clinical Research Center, National Hospital Organization Nagoya Medical Center，2）National Institutes of Health, NIAID, LMM，3）Japan Foundation for AIDS Prevention

WorkshopRoom 1（1F Terrsa Hall） Day 1　October 28 [Sun]　13：36～14：36

Genome and gene expression 1Chairs：Yorifumi Satou（ Satou Laboratory, International Research Center for Medical Sciences, Center for AIDS Research,

Kumamoto University）Yasuo Ariumi（ Center for AIDS Research, Kumamoto University）

W1-1-04 Chemical library screening for latency reverting agents to eradicate HIV-1Takaomi Ishida1），Jin Gohda1），Kazuo Suzuki2），Kai Liu1），Xialin Xie1），Hiroaki Takeuchi3），Jun-ichiro Inoue4），Yasushi Kawaguchi5）

1）Research Center for Asian Infectious Diseases. Institute of Medical Science, University of Tokyo，2）Immunovirology Laboratory, St. Vincent Center for Applied Medical Research，3）Department of Molecular Virology, Tokyo Medical and Dental University，4）Division of Cellular and Molecular Biology, The Institute of Medical Science, The University of Tokyo，5）Division of Molecular Virology, The Institute of Medical Science, The University of Tokyo

W1-1-05 Characterization of HIV-1 infected cells in vivo by multi-omics analysisShumpei Nagaoka1,2），Eiryo Kawakami3），Jumpei Ito1,11），Naoko Misawa1），Hirofumi Aso1,5），Shinji Nakaoka6,7），Yorifumi Satou8,9），Katsuyuki Shiroguchi6,10），Yoshio Koyanagi1），Kei Sato1,4,11）

1）Laboratory of Systems Virology, Institute for Frontier Life and Medical Sciences, Kyoto University，2）Graduate School of Biostudies, Kyoto University，3）Medical Sciences Innovation Hub Program (MIH), RIKEN，4）JST CREST，5）Graduate School of Pharmaceutical Sciences, Kyoto University，6）JST PRESTO，7）Institute of Industrial Sciences, The University of Tokyo，8）International Research Center for Medical Sciences (IRCMS), Kumamoto University，9）Center for AIDS Research, Kumamoto University，10）Laboratory for Prediction of Cell Systems Dynamics, RIKEN Center for Biosystems Dynamics Research (BDR)，11）Division of Systems Virology, Department of Infectious Disease Control, Institute of Medical Science, The University of Tokyo

Workshop Day 1

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The 66th Annual Meeting of the Japanese Society for Virology

W1-1-06 Transcriptome analysis of latently infected cells using the dual reporter virus HIVGKO

Hiroyuki Matsui1），Kotaro Shirakawa1），Anamaria Daniela Sarca1），Hirofumi Fukuda1），Shigeki Hirabayashi2），Yasuhiro Murakawa2），Akifumi Takaori-Konddo1）

1）Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University，2）Riken-HMC Clinical Omics Unit, RIKEN Baton Zone Program

W1-1-07 Identification of an intragenic regulatory region within HIV-1 provirus and its transcriptional regulatory mechanismSaori C. Iwase1,2），Misaki Matsuo2），Benjy Jek Yang Tan1,2），Paola Miyazato2），Eriko Kudo1），Kouki Matsuda3），Saiful Islam1,2），Kenji Maeda3），Seiji Okada1），Yorifumi Satou1,2）

1）Center for AIDS Research, Kumamoto University，2）International Research Center for Medical Sciences (IRCMS)，3）National Center for Global Health and Medicine (NCGM) Research Institute, Tokyo, Japan

W1-1-08 Clonal selection of HIV-1-infected cells during ART in an in vitro model of persistent infectionSaiful Islam1,2），Kouki Matsuda3），Benjy Jek Yang Tan1,2），Hiroo Katsuya2），Paola Miyazato2），Saori C. Iwase1,2），Kenji Maeda3），Yorifumi Satou1,2）

1）Satou Project lab, Center for AIDS Research (CAIDS), Kumamoto University，2）International Research Center for Medical Sciences (IRCMS), Kumamoto University，3）National Center for Global Health and Medicine Research Institute, Tokyo, Japan


Genome and gene expression 2Chairs：Shoji Yamaoka（ Department of Molecular Virology, Tokyo Medical and Dental University）

Jun-ichi Fujisawa（ Department of Microbiology, Kansai Medical University）

W1-1-09 Molecular characterization of a new HTLV-1 enhancerMisaki Matsuo1,2），Takaharu Ueno3），Paola Miyazato1,2），Hiroo Katsuya1,2），Masahito Tokunaga4），Kisato Nosaka5），Atae Utsunomiya4），Jun-ichi Fujisawa3），Yorifumi Satou1,2）

1）Center for AIDS Research, Kumamoto University，2）International Research Center for Medical Sciences, Kumamoto University，3）Department of Microbiology, Kansai Medical University，4）Department of Hematology, Imamura Sougou Hospital，5）Department of Hematology, Rheumatology and Infectious Diseases, Kumamoto University Hospital

W1-1-10 HTLV-1 infected asymptomatic carriers versus ATL PBMCs: A single-cell transcriptional profiling approachBenjy Jek Yang Tan1,2,3），Hiroo Katsuya2），Paola Miyazato2），Yoshikazu Uchiyama4），Yasushi Sakurai5），Yorifumi Satou1,2）

1）Center for AIDS Research (CAIDS), Kumamoto University，2）International Research Center for Medical Sciences (IRCMS), Kumamoto University，3）Graduate School of Medical Sciences, Kumamoto University，4）Department of Medical Physics, Faculty of Life Sciences, Kumamoto University，5）Division of Informatics and Energy, Faculty of Advanced Life Science and Technology, Kumamoto University

W1-1-11 Comprehensive analysis of proviral sequences in HTLV-1 and HTLV-2 carriersTakafumi Shichijo1,2），Jun-ichiro Yasunaga1），Kazuya Shimura1），Kei Sato3,4），Yoshio Koyanagi5），Patrick Green6），Edward Murphy7），Masao Matsuoka1,2）

1）Laboratory of Virus Control, Institute for Frontier Life and Medical Sciences, Kyoto University，2）Department of Hematology, Rheumatology and Infectious Diseases, Kumamoto University School of Medicine，3）Division of Systems Virology, Institute of Medical Science, The University of Tokyo，4）CREST, JST，5）Laboratory of Systems Virology, Institute for Frontier Life and Medical Sciences, Kyoto University，6）Center for Retrovirus Research, The Ohio State University，7）Departments of Laboratory Medicine and Epidemiology/Biostatistics, University of California San Francisco

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Genome and gene expression 3Chairs：Michiaki Masuda（ School of Medicine, Department of Microbiology, Dokkyo Medical University）

Takao Masuda（ Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental Universtiy）

W1-1-12 Evaluation of HIV-1 integrase in fusion with reverse-transcriptase in vitroTakao Masuda，Yu-Lun Huang，Paoling Wang，Atsuhiko Hasegawa，Mari KannagiDepartment of Immunotherapeutics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University

W1-1-13 Roles of Rad18 in the late step of HIV-1 replicationHiroyuki Fukuda1），Mariko Inoue1），Koudai Kawano1），Satoshi Tateishi2），Yasuo Ariumi1）

1）Center for AIDS Research, Kumamoto University，2）Institute of Molecular Embryology and Genetics, Kumamoto University

W1-1-14 The Q4R mutation accelerates kinetics of reverse transcription and initiation of uncoating of IFN-β hypersensitive HIV-1 capsid mutantAkatsuki Saito1），Joao I Mamede2），Tahmina Sultana1），Kyotaro Nohata1），Emi E Nakayama1），Tatsuo Shioda1），Thomas J Hope2）

1）Research Institute for Microbial Diseases, Osaka University, Osaka, Japan，2）Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

W1-1-15 Promotion of polysome formation of murine leukemia virus env-mRNAKenshi Aburatani，Akiko Sirai，Sayaka Takase-YodenDepartment of Bioinformatics, Graduate School of Engineering, Soka University


Assembly and release 1Chairs：Kenzo Tokunaga（ Department of Pathology, National Institute of Infectious Diseases）

Hiroaki Takeuchi（ Department of Molecular Virology, Tokyo Medical and Dental University）

W1-1-16 Apolipoprotein E is an HIV-1-inducible inhibitor of viral production and infectivity in macrophagesYasuo Ariumi1），Rokeya Siddiqui1），Mikinori Ueno1），Hesham Nasser1），Ryota Koba2），Farzana Bhuyan1），Osamu Noyori1），Mariko Inoue1），Takayuki Hishiki3），Sayaka Sukegawa4,5），Eri Miyagi4），Klaus Strebel4），Shuzo Matsushita1），Kunitada Shimotohno6），Shinya Suzu1）

1）Center for AIDS Research, Kumamoto University，2）Department of Veterinary Medicine, Nihon University，3）Kanagawa Prefectural Institute of Public Health，4）NIAID, NIH, USA，5）Clinical Research Center, Nagoya Medical Center，6）Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine

W1-1-17 An SIV Vpu can antagonize human BST-2/tetherinTakeshi Yoshida，Weitong Yao，Saki Hashimoto，Hiroaki Takeuchi，Shoji YamaokaDepartment of Molecular Virology, Tokyo Medical and Dental University (TMDU)

W1-1-18 Endogenous activation of BST-2 by CRISPR reduces HIV-1 replicationKenzo Tokunaga1），Yanzhao Zhang1），Seiya Ozono1,2），Weitong Yao1,3），Minoru Tobiume1），Shoji Yamaoka3），Satoshi Kishigami2），Hideaki Fujita4）

1）Department of Pathology, National Institute of Infectious Diseases，2）Faculty of Life and Environmental Sciences, University of Yamanashi，3）Department of Molecular Virology, Tokyo Medical and Dental University，4）Faculty of Pharmaceutical Sciences, Nagasaki International University

Workshop Day 1

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Epidemiology 1Chairs：Makoto Ozawa（ Joint Faculty of Veterinary Medicine, Kagoshima University）

Machiko Nishio（ Department of Microbiology, Wakayama Medical University）

W1-1-19 Isolation and identification of avian influenza viruses from apparently healthy ducks at a live-poultry market in IndonesiaKrisnoadi Rahardjo1），Rima R Prasetya1），Aldise M Nastri1），Jezzy R Dewantari1），Arindita N Novianti2），Adi P Rahardjo2），Agnes Theresia S Estoepangestie2），Emmanuel Djoko Poetranto1,2），Gatot Soegiarto1），Yohko K Shimizu1,3），Yasuko Mori3），Kazufumi Shimizu1,3）

1）Indonesia-Japan Collaborative Research Center for Emerging and Re-emerging Infectious Diseases, Institute of Tropical Disease, Airlangga University, Surabaya 60115, Indonesia，2）Faculty of Veterinary Medicine, Airlangga University, Surabaya, Indonesia，3）Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Japan

W1-1-20 Isolation of avian influenza A(H4N6) viruses from ducks at a live-poultry market in IndonesiaRima R Prasetya1），Emmanuel Djoko Poetranto1,2），Aldise M Nastri1），Jezzy R Dewantari1），Krisnoadi Rahardjo1），Anna Lystia Poetranto1），Laksmi Wulandari1），Gatot Soegiarto1），Mitsuhiro Nishimura3），Yohko K Shimizu1,3），Yasuko Mori3），Kazufumi Shimizu1,3）

1）Indonesia-Japan Collaborative Research Center for Emerging and Re-emerging Infectious Diseases, Institute of Tropical Disease, Airlangga University, Surabaya, Indonesia，2）Department of Clinical Science, Faculty of Veterinary Medicine, Airlangga University, Surabaya, Indonesia，3）Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Japan

W1-1-21 Evolution of avian influenza A(H5N1) viruses from poultry in IndonesiaAldise M Nastri1），Anna Lystia Poetranto1），Emmanuel Djoko Poetranto1,2），Jezzy R Dewantari1），Rima R Prasetya1），Krisnoadi Rahardjo1），Laksmi Wulandari1），Gatot Soegiarto1），Mitsuhiro Nishimura3），Yohko K Shimizu1,3），Yasuko Mori3），Kazufumi Shimizu1,3）

1）Indonesia-Japan Collaborative Research Center for Emerging and Re-emerging Infectious Diseases, Institute of Tropical Disease, Airlangga University, Indonesia，2）Department of Clinical Science, Faculty of Veterinary Medicine, Airlangga University, Surabaya, Indonesia，3）Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Japan

W1-1-22 Characterizations of circulating influenza viruses in the 2017/18 season and selection of vaccine viruses for the 2018/19 seasonShinji Watanabe1），Kazuya Nakamura1），Seiichiro Fujisaki1），Masayuki Shirakura1），Emi Takashita1），Tomoko Kuwahara1），Noriko Kishida1），Aya Sato1），Miki Akimoto1），Hideka Miura1），Rie Ogawa1），Hiromi Sugawara1），Kayo Watanabe1），Hiroko Morita1），Keiko Mitamura2），Takashi Abe3），Masataka Ichikawa4），Masahiko Yamazaki5），Takato Odagiri1）， The Influenza Surveillance Group of Japan6）

1）Influenza Virus Research Center, National Institute of Infectious Diseases (NIID)，2）Eiju General Clinic，3）Abe Children's Clinic，4）Ichikawa Children's Clinic，5）Zama Children's Clinic，6）Public Health Institutes of Local Government in Japan

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WorkshopRoom 2（2F AV Study Room） Day 1　October 28 [Sun]　13：00～14：00

Acquired immunity and vaccines 1Chairs：Masashi Shingai（ Laboratory for Biologics Development, Research Center for Zoonosis Control, Hokkaido

University）Tokiko Watanabe（ Division of Virology, Department of Microbiology and Immunology, Institute of Medical

Science, the University of Tokyo）

W1-2-01 Mechanisms of antibody-mediated protection against H5N1 influenza virus infectionReiko Yoshida1），Ema Qurnianingsih2），Rashid Manzoor1），Mari Ishijima1），Asako Shigeno1），Hiroko Miyamoto1），Manabu Igarashi1），Chairul A Nidom3），Ayato Takada1）

1）Research Center for Zoonosis Control, Hokkaido University，2）School of Medicine, Universitas Airlangga, Indonesia，3）Faculty of Veterinary Medicine, Universitas Airlangga, Indonesia

W1-2-02 Identification of novel injectable adjuvants for influenza vaccine in miceHuapeng Feng1），Makoto Yamashita1），Tiago Jose Da Silva Lopes2），Tokiko Watanabe1），Yoshihiro Kawaoka1,2,3）

1）Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan，2）Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA，3）Department of Special Pathogens, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan

W1-2-03 Inactivated whole influenza virus particle vaccine induces potent immune responses in cynomolgus macaquesSaori Suzuki1），Yasushi Itoh1），Cong Thanh Nguyen1），Hirohito Ishigaki1），Masashi Shingai2,3），Takuji Daito2），Naoki Nomura2），Hiroshi Kida2,3,4），Kazumasa Ogasawara1,5）

1）Division of Pathology and Disease Regulation, Department of Pathology, Shiga University of Medical Science，2）Research Center for Zoonosis Control, Hokkaido University，3）Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University，4）Nagasaki University Collaborating Research Center for the Control of Infectious Diseases，5）Research Center for Animal Life Science, Shiga University of Medical Science

W1-2-04 Inactivated whole influenza virus particle vaccine with balanced immunogenicity and safety as an effectual seasonal influenza vaccineMasashi Shingai1,2），Toshiki Sekiya1,2），Marumi Ohno1），Naoki Nomura1），Takuji Daito1），Saori Suzuki4），Yasushi Itoh4），Kazumasa Ogasawara4），Hiroshi Kida1,2,3）

1）Research Center for Zoonosis Control, Hokkaido University，2）Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University，3）Nagasaki University Collaborating Research Center for the Control of Infectious Diseases，4）Division of Pathology and Disease Regulation, Department of Pathology, Shiga University of Medical Science

W1-2-05 Susceptibility of NIID-MDCK cells to human parainfluenza virus type 3 (HPIV3) in the presence of influenza virusItsuki Hamamoto1），Hitoshi Takahashi1），Katsumi Mizuta2），Takato Odagiri1），Eri Nobusawa1）

1）Influenza Virus Research Center, National Institute of Infectious Diseases，2）Yamagata Prefectural Institute of Public Health

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Acquired immunity and vaccines 2Chairs：Jiro Yasuda（ Department of Emerging Infectious Diseases, Institute of Tropical Medicine, Nagasaki University）

Satoshi Fukuyama（ Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, The University of Tokyo）

W1-2-06 Use of recombinant ML29 platform to generate polyvalent live-attenuated vaccines against Lassa fever and other infectious diseasesMasaharu Iwasaki1,2），Beatrice Cubitt1），Jenny Jokinen3），Igor S. Lukashevich3），Juan C. De La Torre1）

1）Department of Immunology and Microbiology, The Scripps Research Institute，2）International Research Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University，3）Department of Pharmacology and Toxicology, School of Medicine, and the Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases, University of Louisville

W1-2-07 Protection of mice from a lethal challenge with SFTS virus by immunization with a novel recombinant LC16m8 expressing SFTS virus genesTomoki Yoshikawa1），Satoshi Taniguchi1），Hirofumi Kato1），Hikaru Fujii1），Miho Shibamura1），Shumpei Watanabe1），Kazutaka Egawa1），Takuya Inagaki1），Satoko Sugimoto1），Supranee Phanthanawiboon1），Shizuko Harada1），Takeshi Kurosu1），Shuetsu Fukushi1），Masayuki Shimojima1），Souichi Yamada1），Shigeru Morikawa2），Masayuki Saijo1）

1）Department of Virology I, National Institute of Infectious Diseases，2）Department of Veterinary Science, National Institute of Infectious Diseases

W1-2-08 Platform for rotavirus vaccine development using plasmid-based reverse geneticsYuta Kanai1），Takahiro Kawagishi1），Misa Onishi1），Pannacha Pimfhun1），Ryotaro Nouda1），Jeffery Nurdin1），Keiichiro Nomura1），Hiroshi Ushijima2），Takeshi Kobayashi1）

1）Department of Virology, Research Institute for Microbial Diseases, Osaka University，2）Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan


Acquired immunity and vaccines 3Chairs：Yasuko Mori（ Division of Clinical Virology, Kobe University Graduate School of Medicine）

Shinji Ohno（ Department of Virology, Graduate School of Medicine, Universiyt of the Ryukyus）

W1-2-09 Humanization of the neutralizing antibodies against human herpesvirus 6BBochao Wang，Mitsuhiro Nishimura，Yasuko MoriDivision of Clinical Virology, Center for Infectious Diseases, Kobe University Graduate School of Medicine

W1-2-10 Analysis of neutralizing antibody responses to DENV type 2 and viremia levels during DENV infection in a common marmoset modelNor Azila Muhammad Azami1），Meng Ling Moi2），Yasushi Ami3），Yuriko Suzaki3），Chang-Kweng Lim1），Satoshi Taniguchi1），Masayuki Saijo1），Tomohiko Takasaki4），Ichiro Kurane5）

1）Department of Virology 1, National Institute of Infectious Diseases Japan，2）Institute of Tropical Medicine, Nagasaki University，3）Kanagawa Prefectural Institute of Public Health，4）Division of Experimental Animal Research, National Institute of Infectious Diseases Japan，5）National Institute of Infectious Diseases Japan

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W1-2-11 Systemic and mucosal immune responses in horses infected with equine herpesvirus type-1 and the protective effect after subsequent challengeHiroshi Bannai，Manabu Nemoto，Koji Tsujimura，Takashi Yamanaka，Hiroshi Kokado，Takashi Kondo，Tomio MatsumuraEquine Research Institute, Japan Racing Association


Antivirals 1Chairs：Seiya Yamayoshi（ Division of Virology, Institute of Medical Science, The University of Tokyo）

Maki Kiso（ Division of Virology, Institute of Medical Science, The University of Tokyo）

W1-2-12 In vitro characterization of multidrug-resistant influenza A(H1N1)pdm09 viruses carrying a dual amino acid substitutionEmi Takashita1），Seiichiro Fujisaki1），Masaru Yokoyama2），Masayuki Shirakura1），Kazuya Nakamura1），Tomoko Kuwahara1），Noriko Kishida1），Hironori Sato2），Shinji Watanabe1），Takato Odagiri1）， The Influenza Virus Surveillance Group of Japan3）

1）Influenza Virus Research Center, National Institute of Infectious Diseases，2）Pathogen Genomics Center, National Institute of Infectious Diseases，3）The Influenza Virus Surveillance Group of Japan

W1-2-13 Differences in the ease with which mutant viruses escape from human monoclonal antibodies against the HA stem of influenza A virusSeiya Yamayoshi1），Atsuhiro Yasuhara1），Mutsumi Ito1），Ryuta Uraki1），Yoshihiro Kawaoka1,2,3）

1）Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo，2）Department of Special Pathogens, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo，3）Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison

W1-2-14 Preparation of monoclonal antibodies to detect multiple clades of influenza A/H5 virusesHitoshi Takahashi，Shiho Nagata，Takato Odagiri，Tsutomu KageyamaInfluenza Virus Research Center, National Institute of Infectious Diseases


Epidemiology 2Chairs：Shuzo Urata（ Department of Emerging Infectious Diseases, Institute of Tropical Medicine, Nagasaki University）

Kentaro Yoshii（ Laboratory of Public Health, Faculty of Veterinary Medicine, Hokkaido University）

W1-2-15 International spreading of influenza A(H1N1)pdm09 virus by the Hajji returneesKazufumi Shimizu1,2），Yohko K Shimizu1,2），Laksmi Wulandari2,3），Muhammad Amin3），Aldise M Nastri2），Jezzy R Dewantari2），Rima R Prasetya2），Edith F Puruhito2），Gatot Soegiarto2），Yasuko Mori1）

1）Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Japan，2）Indonesia-Japan Collaborative Research Center, Institute of Tropical Disease, Airlangga University, Surabaya, Indonesia，3）Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Airlangga University, Surabaya, Indonesia

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W1-2-16 High seroprevalence of hantavirus antibody among chronic kidney disease unknown etiology (CKDu) patients in Sri LankaKumiko Yoshimatsu1,4），Sarathukumara D Yomani2），Chandika D. Gamage2），Sithumini Madubashini Wimalasiri Lokupathirage3），Devinda S. Muthusinghe4），Nishanta Nanayakkara5），Lishanta Gunarathne6），Kenta Shimizu1），Yoshimi Tsuda1），Jiro Arikawa1）

1）Department of Microbiology and Immunology, Faculty of Medicine, Hokkaido University，2）Department of Microbiology, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka，3）Graduate School of Medicine, Hokkaido University，4）Graduate School of Infectious Diseases, Hokkaido University，5）Nephrology and Transplantation Unit, Teaching Hospital Kandy, Sri Lanka，6）Renal Clinic, District Hospital, Girandurukotte, Sri Lanka

W1-2-17 Rodent host species identification and serological evidence for Thailand orthohantavirus antibody among rodents in dry zones of Sri LankaSithumini Madubashini Wimalasiri Lokupathirage1），Devinda S. Muthusinghe5），Kenta Shimizu2），Kumpei Nishigami1），Kisho Noda6），Yoshimi Tsuda2），Yomani D. Sarathkumara3），Chandika D. Gamage3），Hideki Ebihara4），Jiro Arikawa2），Kumiko Yoshimatsu2,5）

1）Department of Microbiology & Immunology, Graduate School of Medicine, Hokkaido University，2）Department of Microbiology & Immunology, Faculty of Medicine, Hokkaido University，3）Department of Microbiology, Faculty of Medicine, University of Peradeniya, Sri Lanka，4）Department of Molecular Medicine, Mayo Clinic, USA，5）Graduate School of Infectious Diseases, Hokkaido University，6）School of Medicine, Hokkaido University


Epidemiology 3Chairs：Jiro Arikawa（ Department of Microbiology and Infectious Diseases, Graduate School of Medicine, Hokkaido

University）Ayato Takada（ Research Center for Zoonosis Control, Hokkaido University）

W1-2-18 Seroprevalence of filovirus infection of Rousettus aegyptiacus bats in ZambiaMasahiro Kajihara1），Katendi Changula2），Akina Mori-Kajihara1），Yoshiki Eto1），Hiroko Miyamoto1），Reiko Yoshida1），Asako Shigeno1），Bernard M Hang'ombe2），Yongjin Qiu1），Mwizabi Daniel3），David Squarre3），Hirohito Ogawa4），Hayato Harima1），Edgar Simulundu2），Tatsunari Kondoh1），Masahiro Sato1），Yoshihiro Takadate1），Victor Mukonka5），Aaron S Mweene2），Ayato Takada1,2）

1）Hokkaido University Research Center for Zoonosis Control，2）School of Veterinary Medicine, University of Zambia，3）Department of National Parks and Wildlife, Ministry of Tourism and Arts, Zambia，4）Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences，5）Zambia National Public Health Institute, Ministry of Health, Zambia

W1-2-19 Re-emergence of Reston Ebola virus in Cynomolgus monkeys in the Philippines, 2015Shuetsu Fukushi1），Satoshi Taniguchi1），Shumpei Watanabe1），Takeshi Kurosu1），Tomoki Yoshikawa1），Masayuki Shimojima1），Shigeru Morikawa2），Masayuki Saijo1）

1）Department of Virology 1, National Institute of Infectious Diseases，2）Department of Veterinary Science, National Institute of Infectious Diseases

W1-2-20 Detection of rare G11P[25] and G9P[19] rotavirus A strains from adult patients with acute diarrhoea in NepalHanae Takatsuki1,2），Toyoko Nakagomi1,2），Punita Gauchan2），Osamu Nakagomi2），Ryuichiro Atarashi1）

1）Department of Infectious diseases, Faculty of medicine, University of Miyazaki，2）Department of Molecular Epidemiology, Graduate School of Biomedical Sciences, Nagasaki University

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W1-2-21 Development of fluorescent antibody virus neutralization assay for the diagnosis of Fowl Aviadenoviruses infectionKhompakorn Thanasut1），Daiki Ogura1），Kan Fujino1），Motoko Taharaguchi2），Satoshi Taharaguchi1）

1）Laboratory of Veterinary Microbiology II, Department of Veterinary Medicine, School of Veterinary Medicine, Azabu University，2）Division of Experimental Animal Research, National Institute of Infectious Diseases

WorkshopRoom 3（2F Medium Conference Room） Day 1　October 28 [Sun]　13：00～13：36

Genome and gene expression 4Chairs：Masamichi Muramatsu（ Department of Virology II, National Institute of Infectious Diseases）

Ikuo Shoji（ Division of Infectious Disease Control, Center for Infectious Diseases, Kobe University Graduate School of Medicine）

W1-3-01 Involvement of SET nuclear proto-oncogene in the regulation of HBV cccDNAMasahiko Ito，Tetsuro SuzukiDepartment of Virology and Parasitology, Hamamatsu University School of Medicine

W1-3-02 Regulation of HBV pregenomic RNA splicingKenji Nakashima，Noriomi Ito，Masahiko Ito，Tetsuro SuzukiDepartment of Virology and Parasitology, Hamamatsu University School of Medicine

W1-3-03 Regulation of the transcription of hepatitis B virus by E2F1Tsubasa Munakata，Michinori KoharaDepartment of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science


Assembly and release 2Chairs：Takasuke Fukuhara（ Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka

University）Kei Miyakawa（ Department of Microbiology, Yokohama City University）

W1-3-04 Galectin-9 restricts HBV replication through an autophagy-mediated regulationKei Miyakawa，Akihide RyoDepartment of Microbiology, Yokohama City University School of Medicine

W1-3-05 HCV-induced activation of JNK/Itch signaling pathway is involved in the release of infectious viral particlesLin Deng，Chieko Matsui，Takayuki Abe，Ikuo ShojiDivision of Infectious Disease Control, Center for Infectious Diseases, Kobe University Graduate School of Medicine

Workshop Day 1

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W1-3-06 Hepatitis C virus infection triggers the transactivation of aryl hydrocarbon receptor to rearrange hepatic lipid biosynthesisHirofumi Ohashi1,2），Syo Nakajima1,2），Sulyi Kim2），Ryosuke Suzuki2），Hideki Aizaki2），Masayoshi Fukasawa3），Shinji Kamisuki1），Fumio Sugawara1），Naoko Ohtani1），Masamichi Muramatsu2），Takaji Wakita2），Koichi Watashi1,2）

1）Tokyo University of Science Graduate School of Science and Technology，2）Department of Virology II, National Institute of Infectious Diseases，3）Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases


Replication of virus genome 1Chairs：Tetsuro Suzuki（ Hamamatsu University School of Medicine）

Kohji Moriishi（ Department of Microbiology, Division of Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi）

W1-3-07 HCV RNA replication impairs selective autophagy-induced degradation of ubiquitinated proteinsHiroyuki Mori1），Takasuke Fukuhara1），Chikako Ono1），Tomokazu Tamura1），Asuka Sato1），Yuzy Fauzyah1），Masami Wada1），Toru Okamoto1），Takeshi Noda2），Tamotsu Yoshimori3），Yoshiharu Matsuura1）

1）Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University，2）Center for Frontier Oral Science, Graduate School of Dentistry, Osaka University，3）Department of Genetics, Graduate School of Medicine, Osaka University

W1-3-08 Identification of comparable miRNAs with miR-122 on the propagation of hepatitis C virusChikako Ono1），Takasuke Fukuhara1），Daisuke Okuzaki2），Tomokazu Tamura1），Hiroyuki Mori1），Asuka Sato1），Takuma Izumi1），Yuzy Fauzyah1），Toru Okamoto1），Yoshiharu Matsuura1）

1）Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University，2）Department of Infection Metagenomics, Research Institute for Microbial Diseases, Osaka University

W1-3-09 Critical role of NS5A-ISGylation in the efficient HCV RNA replicationTakayuki Abe1），Nanae Minami1），Bawono Gandi Rheza1），Chieko Matsui1），Lin Deng1），Takasuke Fukuhara2），Yoshiharu Matsuura2），Ikuo Shoji1）

1）Division of Infectious Disease Control Center for Infectious Diseases, Kobe University Graduate School of Medicine，2）Department of Molecular Virology, Research Institute for Microbial Diseases (RIMD) Osaka University


Replication of virus genome 2Chairs：Hideki Aizaki（ Department of Virology II, National Institute of Infectious Diseases）

Masanori Ikeda（ Persistent and Oncogenic Viruses, Center for Chronic Viral Diseases, Kagoshima University）

W1-3-10 Screening of the new host factors necessary for HBV proliferation using plural human cell linesYouki Ueda1），Hiromichi Dansako1），Shinya Satoh1），Kunitada Shimotohno2），Nobuyuki Kato1）

1）Department of Tumor Virology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences，2）Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine

41


W1-3-11 Comprehensive in vitro screening to identify the host proteins that binds to HBV-S protein using wheat cell-free technologyHirotaka Takahashi1），Takahiro Iwasaki1），Hiroyuki Takeda1），Masahiko Ito2），Takasuke Fukuhara3），Tetsuro Suzuki2），Yoshiharu Matsuura3），Tatsuya Sawasaki1）

1）Proteo-Science Center, Ehime University，2）Department of Virology and Parasitology, Hamamatsu University School of Medicine，3）Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University

W1-3-12 Construction of self-replicating hepatitis B virus genome containing split-Cre geneAya Maekawa1），Manabu Yamasaki1），Yuya Kato2），Izumu Saito1）

1）Laboratory of Virology, Institute of Microbial Chemistry (BIKAKEN)，2）PharmaBio Corporation


Epidemiology 4Chairs：Takeshi Kurosu（ Department of Virology Ⅰ, National Institute of Infectious Diseases）

Emi E. Nakayama（ Department of Viral Infections, Research Institute for Microbial Diseases, Osaka University）

W1-3-13 Detection of Zika Virus infection in MyanmarNgwe Tun Mya Myat1），Aung Kyaw Kyaw2），Saw Wut Hmone3），Shingo Inoue1），Meng Ling Moi1），Daisuke Hayasaka1），Futoshi Hasebe1），Kyaw Zin Thant2），Kouichi Morita1）

1）Department of Virology, Institute of Tropical Medicine, Nagasaki University，2）Virology Division, department of Medical Research, Yangon, Myanmar，3）University of Medicine-1, Yangon, Myanmar

W1-3-14 Development of dengue virus serotype specific Non-structural protein 1 capture immunochromatographic assayEmi E Nakayama1），Takashi Kato2），Yoshiki Takashima2），Manami Inoue2），Chiaki Kitamura2），Akio Okubo2），Tatsuo Shioda1）

1）Research Institute for Microbial Diseases, Osaka University，2）ARKRAY Inc.

W1-3-15 First isolation and phylogenetic characterization of Sapelovirus from piglets in AfricaHayato Harima1），Masahiro Kajihara2），Edgar Simulundu3），Eugene Bwalya3），Joseph Ndebe3），Yongjin Qiu1），Bernard M Hang'ombe3），Aaron S Mweene3），Ayato Takada2）

1）Hokudai Center for Zoonosis Control in Zambia, Research Center for Zoonosis Control, Hokkaido University，2）Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University，3）School of Veterinary Medicine, the University of Zambia

W1-3-16 Propagation of human rhinovirus C in differentiated immortalized human airway epithelial cellsMina Nakauchi1），Ikuyo Takayama1），Shinji Saito1），Noriyo Nagata2），Atsushi Kaida3），Hideyuki Kubo3），Kunihiro Oba4），Tsutomu Kageyama1），Takato Odagiri1）

1）Influenza Virus Research Center, National Institute of Infectious Diseases，2）Department of Pathology, National Institute of Infectious Diseases，3）Division of Microbiology, Osaka Institute of Public Health，4）Department of Pediatrics, Showa General Hospital

Workshop Day 1

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WorkshopRoom 4（3F Conference Room B & C） Day 1　October 28 [Sun]　13：00～13：48

Innate immunity 1Chairs：Yoshio Koyanagi（Institute for Frontier Life and Medical Sciences, Kyoto University）

Osamu Takeuchi（ Department of Virus Research, Laboratory of Infection and Prevention, Institute for Frontier Life and Medical Sciences, Kyoto University）

W1-4-01 Recognition of Influenza A virus by DNA sensorsMiyu Moriyama，Takeshi IchinoheDivision of Viral Infection, Department of Infectious Disease Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo

W1-4-02 Influenza virus restriction factor MxA functions as inflammasome receptor in respiratory epitheliumSangjoon Lee1），Kyosuke Nagata2），Atsushi Kawaguchi1,2）

1）Ph.D. Program in Human Biology, School of Integrative and Global Majors, University of Tsukuba，2）Department of Infection Biology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan

W1-4-03 Asymmetric activation of innate immunity after apical and basolateral infection of polarized human intestinal epithelial cells with reovirusChieko Inoue1），Ryosuke Negoro2），Takuma Hotani2），Kazuo Takayama1,2,3,4），Hiroyuki Mizuguchi1,2,3,5），Fuminori Sakurai1,2）

1）School of Pharmaceutical Sciences, Osaka University，2）Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University，3）Laboratory of Hepatocyte Regulation, National Institute of Biomedical Innovation, Health and Nutrition，4）Japan Science and Technology Agency, Precursory Research for Embryonic Science and Technology，5）Global Center for Medical Engineering and Informatics, Osaka University

W1-4-04 Identification of novel gamma interferon-inducible anti-retrovirus host factorsYoshinao Kubo1），Mai Izumida2），Yuria Umemura2），Hideki Hayashi3），Toshifumi Matsuyama3）

1）Program for Nurturing Global Leaders in Tropical and Emerging Communicable Diseases, Nagasaki University，2）Institute of Tropical Medicine, Nagasaki University，3）Graduate School of Biomedical Sciences, Nagasaki University


Innate immunity 2Chairs：Takashi Mino（ Laboratory of Infection and Prevention, Institute for Frontier Life and Medical Sciences, Kyoto

University）Hiroyuki Oshiumi（ Faculty of Life Scineces, Department of Immunology, Kumamoto University）

W1-4-05 Highly expression of STING restricts HBV infection by mediating the induction of type III interferon in human immortalized hepatocyte NKNT-3Hiromichi Dansako1），Hirotaka Imai1），Youki Ueda1），Shinya Satoh1），Kunitada Shimotohno2），Nobuyuki Kato1）

1）Department of Tumor Virology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences，2）The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine

W1-4-06 MAVS-independent activity of interferon regulatory factor 1 restricts replication of hepatotropic RNA virusesDaisuke Yamane1,3），Asuka Hirai-Yuki2,3），Michinori Kohara1），Stanley M. Lemon3）

1）Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science，2）Division of Experimental Animal Research, National Institute of Infectious Diseases, Tokyo, Japan，3）The University of North Carolina at Chapel Hill

43


W1-4-07 Innate immune response to Rubella virus infection in human neural cellsHuanan Liao，Takujitus Watanabe，Shigeyoshi Fujiwara，Hiroyuki NakamuraDepartment of Allergy and Clinical Immunology, National center for Child Health and Development

W1-4-08 Zika virus NS2A protein inhibits NLRP3 inflammasome-mediated interleukin-1β secretionShota Chino1,2），Miyu Moriyama1），Takeshi Ichinohe1）

1）Division of Viral Infection, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, The University of Tokyo，2）School of Life Science, Tokyo University of Pharmacy and Life Sciences


Innate immunity 3Chairs：Takeshi Ichinohe（ Division of Viral Infection, Department of Infectious Disease Control, International Research

Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo）Yasutaka Okabe（ Laboratory of Molecular Genetics, Institute for Frontier Life and Medical Sciences, Kyoto

University）

W1-4-09 Detailed functional mapping of the paramyxovirus accessory proteins in viral infectionTakashi Irie1），Ryoko Kawabata1），Asuka Yoshida2），Mahito Nakanishi3），Takemasa Sakaguchi1）

1）Department of Virology, Institute of Biomedical & Health Sciences, Hiroshima University，2）Laboratory Animal Research Center, The Institute of Medical Science, The University of Tokyo，3）Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST)

W1-4-10 Inhibition of the IFN-α-inducible phosphorylation of Tyk2/Jak1 by Sendai virus C proteinKosuke Oda，Takemasa SakaguchiGraduate School of Biomedical and Health Sciences, Hiroshima University

W1-4-11 Different Rabies virus P protein isoforms contribute to the suppression of IFN induction in neural and muscle cellsKazuma Okada1），Naoto Ito1,2），Tatsuki Takahashi2），Shoko Nishiyama1），Makoto Sugiyama1,2）

1）Laboratory of Zoonotic Diseases, Faculty of Applied Biological Sciences, Gifu University，2）The United Graduate School of Veterinary Sciences, Gifu University

W1-4-12 ADAR2 is involved in Borna disease virus infection through suppression of inflammatory response genesMako Yanai1,2），Ryo Komorizono1,2），Shohei Kojima1,2），Nadine Gillich3），Masayuki Horie1,4），Akiko Makino1,2），Keizo Tomonaga1,2）

1）Lab. of RNA Viruses, Institute for Frontier Life and Medical Sciences, Kyoto University，2）Department of Mammalian Regulatory Network, Graduate School of Biostudies, Kyoto University，3）Institute of Virology, University Medical Center Freiburg，4）Hakubi Center for Advanced Research, Kyoto University

Workshop Day 1

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Replication of virus genome 3Chairs：Masaki Imai（ Division of Virology, Institute of Medical Science, The University of Tokyo）

Atsushi Kawaguchi（ Faculty of Medicine, University of Tsukuba）

W1-4-13 Development of a reverse genetics system for influenza D virusHiroho Ishida，Haruhiko Kamiki，Hiromichi Matsugo，Tomoya Kobayashi，Akiko Uema，Shin Murakami，Taisuke HorimotoDepartment of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, University of Tokyo

W1-4-14 Identification of influenza virus proteins localized in the nucleolus of virus-infected cellsSho Miyamoto，Ryoma Tamura，Yukiko Muramoto，Keiko Shindo，Masahiro Nakano，Takeshi NodaLaboratory of Ultrastructural Virology, Institute for Frontier Life and Medical Sciences, Kyoto University

W1-4-15 Combinatorial minigenome assays reveal cooperative effects of RNA-dependent RNA polymerases between different mononegavirus familiesYuta Shirogane，Yusuke YanagiDepartment of Virology, Faculty of Medicine, Kyushu University

W1-4-16 Characterization of the L protein interactome of nuclear infecting Borna disease virus 1 by proximity-dependent biotin identification assayBea Clarise Baluyot Garcia1,2），Shohei Kojima1,2），Masayuki Horie1,3），Keizo Tomonaga1,2）

1）Laboratory of RNA Viruses, Institute for Frontier Life and Medical Sciences, Kyoto University，2）Department of Mammalian Regulatory Network, Division of Systemic Life Science, Graduate School of Biostudies, Kyoto University，3）Hakubi Center for Advanced Research, Kyoto University

W1-4-17 Illuminating the molecular choreography of multi-segmented viral RNA genomesAlexander Borodavka1），Sebastian Strauss2），Don C Lamb3），Ralf Jungmann2）

1）Astbury Centre for Structural Molecular Biology, University of Leeds，2）Max Planck Institute of Biochemistry, Munich, Germany，3）Department of Physical Chemistry, Ludwig-Maximillian University of Munich, Germany


Epidemiology 5Chairs：Masayuki Saijo（ Department of Virology Ⅰ, National Institute of Infectious Diseases）

Masayuki Shimojima（ Department of Virology Ⅰ, National Institute of Infectious Diseases）

W1-4-18 Severe fever with thrombocytopenia syndrome virus (SFTSV) infection among wild animals in Japan (2018)Kango Tatemoto1），Keita Noguchi1），Shohei Minami1），Kenzo Yonemitsu1），Supriyono Supriyono1），Tran Thuy Bao Ngo1），Junko Mizuno1），Ryusei Kuwata1），Ai Takano1），Hiroshi Shimoda1），Masami Suenaga2），Kazuo Suzuki3），Shigeru Morikawa4），Ken Maeda1）

1）Joint Faculty of Veterinary Medicine, Yamaguchi University，2）Yamaguchi prefecture Iwakuni Health and Welfare Center，3）Hikiiwa park center，4）Department of Veterinary Science, National Institute of Infectious Disease

45


W1-4-19 Occurrence situations of SFTS among cats and dogs in Japan (2017)Keita Noguchi1），Kango Tatemoto1），Shohei Minami1），Kenzo Yonemitsu1），Supriyono Supriyono1），Tran Thuy Bao Ngo1），Junko Mizuno1），Ryusei Kuwata1），Ai Takano1），Hiroshi Shimoda1），Takehisa Soma2），Shigeru Morikawa3），Ken Maeda1）

1）Joint Faculty of Veterinary Medicine, Yamaguchi University，2）Marupi Lifetech Co. Ltd.，3）Department of Veterinary Science, National Institute of Infectious Diseases

W1-4-20 Possible transportation of tick-borne viruses by migratory birdsHiroshi Shimoda1），Shohei Minami1），Ai Takano1），Shiori Aoki1），Junko Mizuno1），Kango Tatemoto1），Kenzo Yonemitsu1），Yono Supri1），Tran Thuy Bao Ngo1），Ryusei Kuwata1），Katsuyoshi Umada2），Noboru Nakamura2），Tomohiro Deguchi2），Ken Maeda1）

1）Joint Faculty of Veterinary Medicine, Yamaguchi University，2）Yamashina Institute of Ornithology

W1-4-21 Incidence and clearance of genital and oral human papillomavirus infection in men: a longitudinal study in Hanoi, VietnamHai Ha Long Le1,2,3），Xiuqiong Bi1），Azumi Ishizaki1），Hung Van Le2,3），Trung Vu Nguyen2），Hiroshi Ichimura1）

1）Department of Viral Infection and International Health, Graduate School of Medical Sciences, Kanazawa University，2）Hanoi Medical University, Hanoi, Vietnam，3）National Hospital of Dermatology and Venereology, Hanoi, Vietnam

WorkshopRoom 5（3F Conference Room D） Day 1　October 28 [Sun]　13：00～14：00

Virus entry 2Chairs：Shin Murakami（ Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, the

University of Tokyo）Michinori Kohara（ Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical

Science）

W1-5-01 Oligomerization of NTCP is required for hepatitis B virus internalizationKento Fukano1,2），Senko Tsukuda1），Mio Ohki3），Sam-Yong Park3），Ryosuke Suzuki1），Hideki Aizaki1），Masamichi Muramatsu1），Takaji Wakita1），Yuki Ogasawara2），Koichi Watashi1）

1）Department of Virology II, National Institute of Infectious Diseases，2）Department of Analytical Biochemistry, Meiji Pharmaceutical University，3）Drug Design Laboratory, Graduate School of Medical Life Science, Yokohama City University

W1-5-02 Cathepsin L is required for entry step of hepatitis E virusShigeo Nagashima，Putu Prathiwi Primadharsini，Tominari Kobayashi，Masaharu Takahashi，Takashi Nishiyama，Tsutomu Nishizawa，Hiroaki OkamotoDivision of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine

W1-5-03 AlphaScreen technology targeting the viral envelope-receptor interaction identified a novel HBV entry inhibitor, rapamycinWakana Saso1,2,3），Senko Tsukuda1），Hirofumi Ohashi1），Kento Fukano1），Ryo Morishita4），Satoko Matsunaga5），Mio Ohki6），Akihide Ryo5），Sam-Yong Park6），Ryosuke Suzuki1），Hideki Aizaki1），Masamichi Muramatsu1），Takaji Wakita1），Tetsuro Matano2,3），Koichi Watashi1）

1）Department of Virology II, National Institute of Infectious Diseases，2）AIDS Research Center, National Institute of Infectious Diseases，3）the Institute of Medical Science, the University of Tokyo，4）CellFree Sciences Co., Ltd.，5）Department of Microbiology, Graduate School of Medicine, Yokohama City University，6）Drug Design Laboratory, Graduate School of Medical Life Science, Yokohama City University

Workshop Day 1

46


W1-5-04 CXADR acts as a receptor molecule for BtAdVsTomoya Kobayashi1），Hiromichi Matsugo1），Junki Maruyama2），Haruhiko Kamiki1），Hiroho Ishida1），Akiko Uema1），Ken Maeda3），Ayato Takada2），Shin Murakami1），Taisuke Horimoto1）

1）Laboratory of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo，2）Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University，3）Joint Faculty of Veterinary Medicine, Yamaguchi University

W1-5-05 Infection process of a dinoflagellate-infecting giant virusKeizo Nagasaki1），Yuji Tomaru2），Yoshihito Takano1）

1）Team Aqua-Virus, Kochi University，2）National Research Institute of Fisheries and Environment of Inland Sea


Genome and gene expression 5Chairs：Tadasuke Naito（ Department of Microbiology, Kawasaki Medical School）

Takeshi Tsugawa（ Department of Pediatrics, Sapporo Medical University School of Medicine）

W1-5-06 Acetylation of PA subunit constructing viral RNA-dependent RNA polymerase of influenza A virus modulates the endonuclease activityDai Hatakeyama1），Tsugunori Komatsu1），Ayaka Saitoh1），Anna Ohnishi1），Kyoko Makiyama1），Seiryo Ogata2），Sumio Ohtsuki2），Takashi Kuzuhara1）

1）Faculty of Pharmaceutical Sciences, Tokushima Bunri University，2）Faculty of Life Sciences, Kumamoto University

W1-5-07 Role of nuclear localization of MERS coronavirus nsp1 in viral replicationWataru Kamitani1），Tsubasa Yamada1），Kengo Kawachi1），Yutaka Terada1），Yoshiharu Matsuura2）

1）Laboratory of Clinical Research on Infectious Diseases, Research Institute for Microbial Diseases, Osaka University，2）Dept. Molecular Virology, Research Institute f or Microbial Diseases, Osaka University

W1-5-08 Molecular epidemiological analysis of rotaviruses obtained from rotavirus-associated encephalitis /encephalopathy patientsYoshiki Kawamura1），Masaru Ihira2），Satoshi Komoto3），Koki Taniguchi3），Tetsushi Yoshikawa1）

1）Department of Pediatrics, Fujita Health University School of Medicine，2）Fujita Health University School of Health Sciences, Faculty of Clinical Engineering，3）Fujita Health University School of Medicine, Department of Virology and Parasitology

W1-5-09 Development of efficient and simple reverse genetics system based on only rotavirus cDNAsSaori Fukuda1），Tomihiko Ide1），Naoto Ito2,3），Makoto Sugiyama2,3），Tetsushi Yoshikawa4），Takayuki Murata1），Koki Taniguchi1），Satoshi Komoto1）

1）Department of Virology and Parasitology, Fujita Health University School of Medicine，2）The United Graduate School of Veterinary Sciences, Gifu University，3）Laboratory of Zoonotic Diseases, Faculty of Applied Biological Sciences, Gifu University，4）Department of Pediatrics, Fujita Health University School of Medicine

47



Assembly and release 3Chairs：Masae Itoh（ Faculty of Bioscience, Nagahama Institute of Bio-Science and Technology）

Akiko Makino（ Laboratory of RNA viruses, Institute for Frontier Life and Medical Sciences, Kyoto University）

W1-5-10 Understanding influenza A virus budding by direct visualization of viral ribonucleoproteins at the plasma membraneI-Hsuan Wang1），Jiro Usukura2），Yoshihiro Kawaoka1,3,4）

1）Division of Virology, Institute of Medical Science, the University of Tokyo，2）Structural Biology Research Center, Graduate School of Science, Nagoya University，3）Department of Special Pathogens, International Research Center for Infectious Diseases, Institute of Medical Science, the University of Tokyo，4）Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison

W1-5-11 Identification and functional analysis of the host factors that regulate Chikungunya virus infectionShiho Torii1），Yuji Wada1），Michihito Sasaki1），Jody Hobson-Peters2），Roy A. Hall2），Yasuko Orba1），Hirofumi Sawa1,3,4）

1）Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan，2）Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland,Brisbane, Australia，3）Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University, Sapporo, Japan，4）Global Virus Network, Baltimore, MD, USA

W1-5-12 Human parainfluenza virus type 2 promotes filamentous actin formation through the interaction of its V protein with profilin2Keisuke Ohta1），Yusuke Matsumoto1），Masato Tsurudome2），Machiko Nishio1）

1）Department of Microbiology, Wakayama Medical University，2）Department of Biomedical Sciences, Chubu University


Replication of virus genome 4Chairs：Motoyuki Otsuka（ Department of Gastroenterology, Graduate School of Medicine, the Universtiy of Tokyo）

Kazuhiko Katayama（ Graduate School of Infection Control Sciences, Viral Infection Control Sciences-Ⅰ, Kitasato University, Kitasato Institute for Life Sciences）

W1-5-13 Development and use of chronological and real-time monitoring system of hepatitis C virus RNA replicationXiaoyu Li1），Masahiko Ito1），Kenji Nakashima1），Haruyo Aoyagi2），Hideki Aizaki2），Tetsuro Suzuki1）

1）Department of Virology and Parasitology, Hamamatsu University School of Medicine，2）Department of Virology II, National Institute for Infectious Disease

W1-5-14 Functional analysis of ER-localized E3 ubiquitin ligases that interact with HCV NS4BRyo Mitsumori1），Hirotaka Takahashi1），Masahiko Ito2），Tetsuro Suzuki2），Takaji Wakita3），Tatsuya Sawasaki1）

1）Proteo-Science Center, Ehime University，2）Department of Virology and Parasitology, Hamamatsu University School of Medicine，3）Department of Virology II, National Institute of Infectious Diseases

Workshop Day 1

48


W1-5-15 Towards development of a human norovirus culture systemAkira Fujimoto1,2），Kei Haga1），Shinya Sugimoto3），Toshiro Sato3），Reiko Todaka1），Kazuyuki Ikeda1），Kazuhiko Katayama1）

1）Kitasato Institute for Life Sciences, Kitasato University，2）Japan Agency for Medical Research and Development，3）Department of Gastroenterology, Keio University School of Medicine, Tokyo, Japan


Replication of virus genome 5Chairs：Kenji Nakashima（ Department of Virology and Parasitology, Hamamatsu University School of Medicine）

Hitoshi Oshitani（ Department of Virology, Tohoku University Graduate School of Medicine）

W1-5-16 Investigation of the functions of RNA structures within the MERS coronavirus genomeYutaka Terada1），Yoshiharu Matsuura2），Wataru Kamitani1）

1）Laboratory of Clinical Research on Infectious Diseases, Research Institute for Microbial Diseases, Osaka University，2）Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University

W1-5-17 Host mRNA surveillance pathway regulates SARS coronavirus replicationKengo Kawachi1），Wataru Kamitani1），Yoshiharu Matsuura2）

1）Laboratory of Clinical Research on Infectious Diseases, Research Institute for Microbial Diseases, Osaka university，2）Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka university

W1-5-18 Mechanisms of NFκB-dependent degradation of human papillomavirus (HPV) E1 proteinTomomi Nakahara，Tohru KiyonoDv.of Carcinogenesis and Prevention, National Cancer Center Research Institute

WorkshopRoom 6（3F Conference Room No.2） Day 1　October 28 [Sun]　13：00～13：36

Diversity and evolution 1Chairs：Takeshi Kobayashi（ Department of Virology, Research Institute for Microbial Diseases, Osaka University）

So Nakagawa（ School of Medicine, Department of Molecular Life Science, Tokai University）

W1-6-01 Identification of endosymbiont RNA virus genomes in Trichomonas vaginalis by FLDSShintaro Shichinohe1,2），Syun-Ichi Urayama3,4），Fumi Murakoshi5），Takuro Nunoura4），Jiro Yasuda1,2）

1）National Research Center for the Control and Prevention of Infectious Diseases (CCPID), Nagasaki university，2）Department of Emerging Infectious Diseases, Institute of Tropical Medicine, Nagasaki University，3）Laboratory of Fungal Interaction and Molecular Biology, University of Tsukuba，4）Research and Development Center for Marine Biosciences, Japan Agency for Marine-Earth Science and Technology (JAMSTEC)，5）Department of Infectious Diseases, Kyoto Prefectural University of Medicine

W1-6-02 Human fecal RNA viromes revealed by FLDSTakuro Nunoura1），Syun-Ichi Urayama1,2），Shinji Fukuda3），Yoshihiro Takaki1）

1）Research and Development Center for Marine Biosciences, JAMSTEC，2）Laboratory of Fungal Interaction and Molecular Biology, University of Tsukuba，3）Institute for Advanced Biosciences, Keio University

49


W1-6-03 Fusogenic bat-borne orthoreovirus p17 protein regulates viral replication in a host-specific mannerRyotaro Nouda1），Takahiro Kawagishi1），Yuta Kanai1），Masayuki Shimojima2），Masayuki Saijo2），Yoshiharu Matsuura3），Takeshi Kobayashi1）

1）Department of Virology, Research Institute for Microbial Diseases, Osaka University，2）Department of Virology I, National Institute of Infectious Diseases，3）Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University


Acquired immunity and vaccines 4Chairs：Kyoko Kohara（ Joint Faculty of Veterinary Medicine, Kagoshima University）

Makoto Takeda（ Department of Virology Ⅲ, National Institute of Infectious Diseases）

W1-6-04 HBs-large protein vaccination via intranasal route with carboxyl vinyl polymer induces strong neutralizing antibody and anti-HBs IgATakahiro Sanada1），Mohammad Enamul Hoque Kayesh2），Haiying Chi2），Naoki Yamamoto1），Kyoko Tsukiyama-Kohara2），Osamu Yoshida3），Yoichi Hiasa3），Hideki Hasegawa4），Masaya Sugiyama5），Masashi Mizokami5），Yasunori Oda6），Yasumasa Goh6），Takashi Miyazaki7），Taizou Kamishita7），Michinori Kohara1）

1）Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science，2）Transboundary Animal Diseases Centre, Joint Faculty of Veterinary Medicine, Kagoshima University，3）Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine，4）Department of Pathology, National Institute of Infectious Diseases，5）Genome Medical Sciences Project, National Center for Global Health and Medicine，6）Beacle, Inc.，7）Toko Yakuhin Kogyo Co., Ltd.

W1-6-05 Generation of monoclonal antibodies against hepatitis B virus preS1 region from antigen-specific memory B cellsKeigo Yato1,2），Taishi Onodera3），Mami Matsuda1），Akira Fujimoto4），Koichi Watashi1），Hideki Aizaki1），Takanobu Kato1），Kohji Moriishi5），Koji Tamura2），Yoshimasa Takahashi3），Takaji Wakita1），Masamichi Muramatsu1），Ryosuke Suzuki1）

1）Department of Virology II, National Institute of Infectious Diseases，2）Department of Biological Science and Technology, Tokyo University of Science，3）Department of Immunology, National Institute of Infectious Diseases，4）Department of Infection Control and Immunology, The Kitasato Institute for Life Sciences，5）Department of Microbiology, Division of Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi

W1-6-06 Characterization of rat hepatitis E virus-like particles expressed in E. coli as a rat model for development of vaccines against hepatitis ETominari Kobayashi，Shigeo Nagashima，Takashi Nishiyama，Tsutomu Nishizawa，Ggis Tan，Putu Prathiwi Primadharsini，Masaharu Takahashi，Hiroaki OkamotoDivision of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine

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Gene therapy and viral vectors 1Chairs：Tomoyuki Honda（ Division of Virology, Department of Microbiology and Immunology, Osaka University Graduate

School of Medicine）Takao Hashiguchi（ Department of Virology, Faculty of Medicine, Kyushu University）

W1-6-07 Development of a CRISPR-Cas9 RNP delivery system using virus-like particlesPeter Gee1,2），Takahiro Iguchi1），Lucy Yang1），Matthew Waller1），Mandy S.y. Lung1），Huaigeng Xu1），Noriko Sasakawa1），Yasuko Abe1），Jun Komano3），Akitsu Hotta1,2）

1）Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University，2）Institute for Integrated Cell and Material Sciences, Kyoto University，3）Department of Clinical Laboratory, Nagoya Medical Center, National Hospital Organization

W1-6-08 Anti-tumor activity of a recombinant oncolytic measles virus, rMV-SLAMblind, against scirrhous gastric cancer cellsChieko Kai1），Koichiro Shoji1），Hyun-Jeong Kwon1），Akihiro Sugai1），Kazuyoshi Yanagihara2），Hideki Yamaguchi3），Tomoko Nakanishi1），Hiroki Sato1），Tomoko Fujiyuki1），Misako Yoneda1）

1）Laboratory Animal Research Center, IMSUT, The University of Tokyo，2）Exploratory Oncology & Clinical Trial Center, National Cancer Center，3）Dept. Cancer Cell Res., Sasaki Institute, Sasaki Foundation

W1-6-09 Influence of anti-measles virus immunity on recombinant measles virus therapy for cancer in immunocompetent tumor modelKanako Moritoh，Koichiro Shoji，Yosuke Amagai，Tomoko Fujiyuki，Hiroki Sato，Misako Yoneda，Chieko KaiThe Institute of Medical Science, The University of Tokyo

W1-6-10 Development of stable reporter rotavirusesPannacha Pimfhun1），Yuta Kanai1），Misa Onishi1），Takahiro Kawagishi1），Ryotaro Nouda1），Jeffery Nurdin1），Yoshiharu Matsuura2），Takeshi Kobayashi1）

1）Department of Virology, Research Institute for Microbial Diseases, Osaka University，2）Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University


Gene therapy and viral vectors 2Chairs：Naoto Ito（ Laboratory of Zoonotic Diseases, Joint Department of Veterinary Sciences, Faculty of Applied

Biological Sciences, Gifu University）Chieko Kai（ International Research Center for Infectious Diseases, Institute of Medical Science, The University of

Tokyo）

W1-6-11 Optically controllable rabies virusMaino Tahara1），Moritoshi Sato2），Mutsuyo Takayama-Ito3），Masayuki Saijo3），Kenzaburo Tani4），Makoto Takeda1）

1）Department of Virology III, National Institute of Infectious Diseases，2）Graduate School of Arts and Sciences, The University of Tokyo，3）Department of Virology I, National Institute of Infectious Diseases，4）The Institute of Medical Science, The University of Tokyo

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W1-6-12 Development and evaluation of neural stem cells expressing BoDV-TK for cancer gene therapyYumiko Komatsu1,2），Keizo Tomonaga1,3,4）

1）Laboratory of RNA Viruses, Institute for Frontier Life and Medical Sciences, Kyoto University，2）The Keihanshin Consortium for Fostering the Next Generation of Global Leaders in Research (K-CONNEX), Kyoto University，3）Department of Mammalian Regulatory Network, Graduate School of Biostudies, Kyoto University，4）Department of Molecular Virology, Graduate School of Medicine, Kyoto University

W1-6-13 Cleavage of viral glycoprotein is involved in the infection efficiency of non-propagating bornaviral vectorMadoka Sakai1,2），Ryo Komorizono1,2），Yumiko Komatsu1,3），Akiko Makino1,2），Keizo Tomonaga1,2,4）

1）Laboratory of RNA Viruses, Institute for Frontier Life and Medical Sciences, Kyoto University，2）Department of Mammalian Regulatory Network, Graduate School of Biostudies, Kyoto University，3）K-CONNEX，4）Department of Molecular Virology, Graduate School of Medicine, Kyoto University

W1-6-14 Generation of chimeric mammalian orthobornavirusAkiko Makino1,2），Kan Fujino3），Keizo Tomonaga1,2,4）

1）Institute for Frontier Life and Medical Sciences, Kyoto University，2）Department of Mammalian Regulatory Network, Graduate School of Biostudies, Kyoto University，3）Laboratory of Microbiology II, School of Veterinary Medicine, Azabu University，4）Department of Molecular Virology, Graduate School of Medicine, Kyoto University


Oncogenesis 1Chairs：Yuetsu Tanaka（ Department of Immunology, Graduate School of Medicine, University of the Ryukyus）

Sayaka Takase-Yoden（ Department of Science and Enginerring for Sustainable Innovation, Faculty of Science and Engineering, Soka University）

W1-6-15 Rediscovery of HTLV-1 Rex: Exploring functional aspects of Rex as the coordinator of viral replication and silencingKazumi Nakano1），Kaoru Uchimaru1），Toshiki Watanabe2）

1）DCBMS, Grad. Sch. Front. Sci., Univ. Tokyo, Tokyo, Japan，2）Dept.Hematol. Res. Hosp., IMSUT, Japan

W1-6-16 A novel method for characterizing Friend virus-induced erythroleukemia stem cellsTetsuo Tsukamoto，Masaaki MiyazawaDepartment of Immunology, Faculty of Medicine, Kindai University

W1-6-17 Identification of cellular factors that interact with jaagsiekte sheep retrovirus envelope proteinNaoyoshi Maeda1），Yasuo Inoshima2），Katsumi Maenaka1,3）

1）Center for Research and Education on Drug Discovery, Faculty of Pharmaceutical Sciences, Hokkaido University，2）Laboratory of Food and Environmental Hygiene, Cooperative Department of Veterinary Medicine, Gifu University，3）Laboratory of Biomolecular Science, Faculty of Pharmaceutical Sciences, Hokkaido University

W1-6-18 L233P mutation of bovine leukemia virus (BLV) Tax protein depressed endothelial cell recruitmentHiroshi Mori，Takafumi Tomiyasu，Yoshiaki Osawa，Katsunori OkazakiLaboratory of Microbilogy and Immunology, Health Sciences University of Hokkaido

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Oncogenesis 2Chairs：Teru Kanda（ Division of Microbiology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University）

Harutaka Katano（ Department of Pathology, National Institute of Infectious Diseases）

W1-6-19 The presence of defective Epstein-Barr virus in patients with chronic active EBV infection and EBV-associated hematological malignancyTakahiro Watanabe1），Yusuke Okuno2），Takayuki Murata3），Yoshitaka Sato1），Yoshinori Ito4），H. M. Abdullah Al Masud1），Fumi Goshima1），Jun-ichi Kawada4），Seishi Ogawa5），Hiroshi Kimura1）

1）Department of Virology, Nagoya University Graduate School of Medicine，2）Center for Advanced Medicine and Clinical Research, Nagoya University Hospital，3）Department of Virology and Parasitology, Fujita Health University School of Medicine，4）Department of Pediatrics, Nagoya University Graduate School of Medicine，5）Department of Pathology and Tumor Biology, Kyoto University Graduate School of Medicine

W1-6-20 EBV LMP1 alters APOBEC3 expression profile, and hypermutates mitochondrial DNAKousho Wakae1,2），Satoru Kondo3），Pham Hai3），Masamichi Muramatsu2），Tomokazu Yoshizaki3）

1）Department of Molecular Genetics, Kanazawa University Graduate School of Medicine，2）Department of Virology II, National Institute of Infectious Diseases，3）Department of Otorhinolaryngology and Head and Neck Surgery, Kanazawa University Graduate School of Medicine

W1-6-21 APOBEC signature mutagenesis in HPV genome and its relevance to cervical carcinogenesisIwao Kukimoto1），Yusuke Hirose2），Yuri Tenjimbayashi2），Mamiko Onuki2），Takashi Iwata3），Koji Matsumoto2）

1）Pathogen Genomics Center, National Institute of Infectious Diseases，2）Department of Obstetrics and Gynecology, Showa University School of Medicine，3）Department of Obstetrics and Gynecology, Keio University School of Medicine

workshop sessions day 1（october 28[sun]） · akatsuki saito 1），joao i mamede2

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