WORKSHOP-CONFERENCE ON ATHEROSCLEROSIS -- SEPTEMBER, 19'[2

INVITED CONTRIBUTORS AND CHAIRMEN

Dr. Colin W. Adams Dr. James M. Beveridge Dept. of Pathology President Guy's Hospital Medical School Acadia University London, U.K. Wolfville, Nova Scotia,

Dr. S. P. Ahuja Canada Dept. of Medicine Dr. Soren Bjorkerud University Hospital Astra Lakemedel AB London, Ontario, Canada 151 85 Sodertalje

Dr. A. Angel Sweden Clinical Investigation Unit Dr. David Blankenhorn Toronto General Hospital 2025 Zonal Avenue Toronto, Ontario, Canada Los Angeles, California,

Dr. John B. Armstrong U.S.A. Community Health Division Dr. Colin M. Bloor 15 Overlea Blvd. Dept. of Pathology Toronto, Ontario, Canada University of California

Dr. Mark L. Armstrong San Diego School of Medicine Cardiovascular Laboratories La Jolla, California, U.S.A. University Hospital Dr. D. Bocking Iowa City, Iowa, U.S.A. Dean, Faculty of Medicine

Dr. Joel Avigan University of Western Ontario National Heart & Lung Institute London, Ontario, Canada National Institutes of Health Dr. George S. Boyd Bethesda, Maryland, U.S.A. Dept. of Biochemistry

Dr. H. J. M. Barnett University of Edinburgh Dept. of Clinical Neurological Medical School

Sciences Teviot Place University HospitaJ Edinburgh, Scotland London, OntariO, Canada Dr. Helen Brown

Dr. J. L. Beaumont Cleveland Clinic Institute National de la Sante Cleveland, Ohio, U.S.A.

et de la Recherche Medicale Dr. Lucien Campeau Hopital Henri Mondor Institut de Cardiologie de 51, Av. du Mal de lattre de Moatreal

Tassigny 5000, est rue Belanger Creteil, France Montreal, P.Q., Canada

Dr. C. G. Becker Dr. Paul Cannon Dept. of Pathology Dept. of Medicine Cornell University Medical College of Physicians &

School Surgeons of Columbia New York, New York, U.S.A. Universi ty

Dr. Earl P. Bendi tt 630 West 168th Street Dept. of Pathology New York, New York, U.S.A. University of Washington Seattle, Washington, U.S.A.

991

992

Dr. L. A. Carlson Dr. King Gustav V Research

Institute Stockholm, Sweden

Dr. K. K. Carroll Dr. Dept. of Biochemistry University of Western Ontario London, Ontario, Canada

Dr. Joe C. Christian Dept. of Medical Genetics Dr. Indiana University Medical

School Riley Residence, 129 100100 W. Michigan Street Dr. Indianapolis, Indiana, U.S.A.

Dr. Thomas B. Clarkson Bowman Gray School of Medicine Dr. Winston-Salem, North Carolina U.S.A.

Mr. J. L. A. Colhoun President, Ontario Heart Dr.

Foundation 310 Davenport Road Toronto, Ontario, Canada

Prof. C. Col ton Arteriosclerosis Center Dr. Massachusetts Institute of

Technology Cambridge, Massachusetts U.S.A.

Dr. F. Connell Dr. Dept. of Medicine Queen's University Kingston, Ontario, Canada

Dr. W. E. Connor Dept. of Internal Medicine Dr. Iowa College of Medicine Iowa City, Iowa, U.S.A.

Dr. Paris Constantinides Dept. of Pathology University of British Columbia Dr. Vancouver, British Columbia Canada

Dr. Gerald R. Cooper Medical Laboratory Section Communicable Disease Center Atlanta, Georgia, U.S.A.

PARTICIPANTS

Eva Csonka 2nd Dept. of Pathology of

Medical University Budapest, Hungary A. S. Daoud Laboratory Services Veterans Administration

Hospital Albany, New York, U.S.A. Jean Davignon Clinical Research Institute llO Pine Avenue Montreal, P.Q., Canada Ralph DePalma 2065 Adelbert Road Cleveland, Ohio, U.S.A. C. G. Drake Dept. of Surgery University Hospital London, Ontario, Canada S. Fedoroff Dept. of Anatomy University of Saskatchewan Saskatoon, Saskatchewan Canada Katti Fischer-Dzoga Dept. of Pathology University of Chicago 950 East 59th Street Chicago, Illinois, U.S.A. Ivan Franz University of Minnesota

Medical School Minneapolis, Minnesota U.S.A. Jack Geer Dept. of Pathology Ohio State University 370 West 9th Street Columbus, Ohio, U.S.A. Seymour Glagov Dept. of Pathology University of Chicago Chicago, Illinois, U.S.A.

PARTICIPANTS

Dr. Charles Glueck General Clinic Research

Center Cincinnati General Hospital Cincinnati, Ohio, U.S.A.

Dr. A. M. Gotto, Jr. Dept. of Medicine Methodist Hospital & Baylor

College of Medicine 6516 Bertner Blvd. Houston, Texas, U.S.A.

Dr. R. A. Goyer Dept. of Pathology University of Western Ontario London, Ontario, Canada

Dr. Ramsay W. Gunton Dept. of Medicine University Hospital London, Ontario, Canada

Dr. Donald B. Hackel Dept. of Pathology

Dr.

Dr.

David Hewitt School of Hygiene Dept. of Biometrics & Epi-

demiology University of Toronto Toronto, Ontario, Canada William Hollander Dept. of Medicine Boston University Medical

School

993

Boston, Massachusetts, U.S.A. Dr. W. L. Holmes

Dr.

Division of Research Lankenau Hospital Philadelphia, Pennsylvania U.S.A. Louis Horlick Dept. of Medicine University of Saskatchewan Saskatoon, Saskatchewan Canada

Duke University Medical Center Dr. Durham, North Carolina, U.S.A.

G. Hornstra Unilever Research Vlaardingen, The Netherlands A. N. Howard

Dr. J. R. Hampton Dept. of Medicine General Hospital University of Nottingham Nottingham, England

Dr. H. Hauss Medizinische Klinik und

Poliklinik der Universitat Munster

Westring, 44 MUnster, Germany

Dr. M. Daria Haust Dept. of Pathology University of Western Ontario London, Ontario, Canada

Dr. Richard J. Havel Dept. of Medicine University of California

Medical Center San Francisco, California U.S.A.

Dr. R. Heimbecker Dept. of Surgery University Hospital London, Ontario, Canada

Dr. Dept. of Medicine Addenbrooke's Hospital Hills Road Cambridge, England

Dr. William B. Insull, Jr.

Dr.

Dr.

Dr.

CentAr for Prevention of Premature Arteriosclerosis

Rockefeller University New York, New York, U.S.A. Bjorn Isaksson Dept. of Clinical Nutrition Sahlgren's Hospital Gothenburg, Sweden H. Jellinek 2nd Dept. of Pathology Semmelweis Medical University Budapest, Hungary Richard J. Jones Dept. of Medicine University of Cll1.Cago Medical

School 950 East 59th Street Chicago, Illinois, U.S.A.

994

Dr. W. J. Keon Division of Cardiothoracic

Surgery ottawa Civic Hospital 1053 Carling Avenue ottawa, Ontario, Canada

Dr. B. S. Langford Kidd Division of Cardiology Dept. of Paediatrics Johns Hopkins Hospital Baltimore, Maryland, U.S.A.

Dr. Gerald A. Klassen Cardiovascular Division Royal Victoria Hospital 687 Pine Avenue West Montreal, P.Q., Canada

Dr. Anatoli Klimov Laboratory of Lipid Metabolism Institute of Experimental

Medicine Kirovski Prospekt 69/71 Leningrad, U.S.S.R.

Dr. Dieter Kramsch Dept. of Medicine Boston University Medical

Center Boston, Massachusetts, U.S.A.

Dr. R. M. Krause Rockefeller University 66th Street & York Avenue New York, New York, U.S.A.

Dr. David Kritchevsky Wistar Institute Philadelphia, Pennsylvania U.S.A.

Dr. A. Kuksis Banting & Best Dept. of

Medical Research University of Toronto 112 College Street Toronto, Ontario, Canada

Dr. Peter O. Kwiterovich Lipid Research Clinic Dept. of Paediatrics Johns Hopkins University

School of Medicine Baltimore, Maryland, U.S.A.

PARTICIPANTS

Dr. K. T. Lee Dept. of Pathology Albany Medical College of

Union University Albany, New York, U.S.A.

Dr. Lena Lewis Cleveland Clinic Cleveland, Ohio, U.S.A.

Dr. L. J. Lewis Cell Culture Laboratory Dept. of Medicine University of Iowa College

of Medicine Iowa City, Iowa, U.S.A.

Dr. J. Lindner Universitats-Krankenhaus

Eppendorf Pathologisches Institut Martinistrasse 2 Hamburg 20, Germany

Dr. J. A. Little Lipid Research Clinic Project University of Toronto 1. Spadina Crescent Toronto, Ontario, Canada

*Dr. Hugh B. Lofland Dept. of Pathology (Bio-

chemistry) Bowman Gray School of Medicine Wake Forest University Winston-Salem, North Carolina U.S.A.

Dr. P. J. Lupien Centre Hopitalier de l'Uni­

versite Laval 2705 Laurier Blvd. Quebec City, P.Q., Canada

Dr. Robert H. Mahley National Institutes of Health Section on Experimental Athero­

sclerosis National Heart & Lung Institute Bethesda, Maryland, U.S.A.

* Deceased

PARTICIPANTS

Dr. Attilio Maseri Dr. Fisiologia Clinica Laboratoria del Consiglio

Nazionale delle Ricerche Via Savi, 8 Pisa, Italy Dr.

Dr. Neville Marsh Queen Elizabeth College University of London Dept. of Physiology Dr. Campden Hill Road London, England

Dr. H. C. McGill, Jr. Dept. of Pathology University of Texas Medical

School Dr. 7703 Floyd Curl Drive San Antonio, Texas, U.S.A.

Dr. G. W. Manning Dept. of Medicine Dr. University Hospital London, Ontario, Canada

Dr. Maurice McGregor Royal Victoria Hospital 687 Pine Avenue West Dr. Montreal, P.Q., Canada

Miss Valerie McGuire Nutrition Coordinator St. Michael's Hospital 30 Bond Street Dr • Toronto, Ontario, Canada

Dr. W. W. Meyer Institute of Pathology University of Mainz Dr. Mainz, Germany

Dr. T. Miettinen Second Dept. of Medicine University Central Hospital Dr. HelSinki, Finland

Dr. C. Richard Minick Dept. of Pathology Cornell University Medical

School New York, New York, U.S.A.

Dr. C. J. Miras Dept. of Biological Chemistry University of Athens School of

Medicine Goudi, Athens, Greece

Maurice Mishkel Lipid Research Laboratory

and Clinic Hamilton General Hospital Hamilton, OntariO, Canada J. R. A. Mitchell Dept. of Medicine General Hospital Nottingham, England S. C. Mitchell

995

Atherogenesis Branch Division of Heart & Vascular

Disease National Institutes of Health Bethesda, Maryland, U.S.A. S. Moore Health Sciences Centre McMaster University Hamilton, OntariO, Canada Robert H. More Dept. of Pathology Pathology Institute McGill University Montreal, P.Q., Canada Ethel Morrison Dept. of Pathology Albany Medical College Union University Albany, New York, U.S.A. J. Fraser Mustard Dean of Medicine McMaster University Hamilton, Ontario, Canada E. A. Nikkila 3rd Dept. of Medicine UniverSity of Helsinki HelSinki, Finland Kaare R. Norum Institute for Nutrition

Research UniverSity of Oslo School of

Medicine Blindern P.O. Box 1046 Oslo, Norway

996

Dr. R. M. O'Neal Dr. Dept. of Pathology University of Oklahoma Oklahoma City, Oklahoma, U.S.A.

Dr. Mar~an A. Packham Dept. of Biochemistry Dr. University of Toronto Toronto, Ontario, Canada

Dr. Rodolfo Paoletti Universita degli Studi Dr. Instituto di Farmacologia

e di Terapia via Andrea del Sarto 21 MUan, Italy Dr.

Dr. J O. Parker Dept. of Medicine Queen's University Kingston, Ontario, Canada

Dr. J. Patelski Medical Academy Dept ~ of Biochemistry Dr. ul. 3wiecickiego 6

~ Poznan, Poland Dr. H. Peeters

Simon Stevin Institute Jeruzalemstraat 34 Dr. Brugge, Belgium

Dr. R. Pick Experimental Atherosclerosis Dr.

Section Cardiovascular Institute Michael Reese Hospital &

Medical Center Chicago, IllinoiS, U.S.A.

Dr. O. J. Pollak Dover Medical Research Center Dr. Dover, Delaware, U.S.A.

Dr. J. C. F. Poole Sir William Dunn School of

Pathology University of Oxford South Parks Road Dr. Oxford, England

Dr. JUrgen Rauterberg Medical Clinic and Policlinic West. Wilhelms University Munster, Germany

David Redwood Cardiology Branch

PARTICIPANTS

National Heart & Lung Institute National Institutes of Health Bethesda, Maryland, U.S.A. S. Renaud Inserm Unite 63 Lyon, France J. Renais Hopital Boucicaut 78, rue de la Convention PariS, France Leslie Robert Laboratoire de Biochimie du

Tussu Conjonctif Universite Paris-Val de Marne Faculte de Medecine 6, rue de General SarraU CreteU, France Robert Roberts Cardiovascular Division Washington UniverSity School

of Medicine St. LouiS, Missouri, U.S.A. Abel L. Robertson, Jr. Case Western UniverSity Cleveland, Ohio, U.S.A. Paul S. Roheim Dept. of Medicine Albert Einstein College of

Medicine Yeshiva University 1300 Morris Park Avenue Bronx, New York, U.S.A. J. Roland Laboratoire d'Anatomie-

Pathologique Hopital Tenon 4, rue de la Chine PariS, France George H. Rothblat Wi star Institute PhUadelphia, Pennsylvania U.S.A.

PARTICIPANTS

Dr. G. Schettler Medizinische Universitats­

klinik Bergheimerstrasse 6900 Heidelberg, Germany

Dr. G. Schlierf Medizinische Universitats­

klinik 6900 Heidelberg Bergheimer Strasse, Germany

Dr. C. J. Schwartz Dept. of Pathology McMaster University Hamilton, Ontario, Canada

Dr. R. Foster Scott Dept. of Pathology

Dr.

Dr.

Dr.

Albany Medical College of Union University

Albany, New York, U.S.A. Dr. A. G. Shaper

MRC Social Medicine Unit London School of Hygiene and

Tropical Medicine

Dr.

997

Jeremiah Stamler Dept. of Community Health &

Preventive Medicine Northwestern University

Medical School Ward Building, 9th Floor 303 East Chicago Avenue Chicago, Illinois, U.S.A. Frank Rees Smith Dept. of Medicine College of Physicians and

Surgeons of Columbia University

New York, New York, U.S.A. Richard W. St. Clair Bowman Gray School of Medicine Wake Forest University Winston-Salem, North Carolina U.S.A.

Olga Stein Lipid Research Laboratory The Hebrew University Hadassah Medical School Jerusalem, Israel Keppel Street, (Gower Street)

London, England Dr. Takio Shimamoto Dr. Y. Stein

Japan Atherosclerosis Research Institute

1-12 Kanda-Awaji-Cho, Chiyoda­Ku

Tokyo, Japan Dr. F. Brian Shorland

Dept. of Food Science & Human Nutrition

Michigan State University East Lansing, Michigan, U.S.A.

Dr. Maia Simionescu Section on Cell Biology Yale University School of

Medicine 333 Cedar Street New Haven, Connecticut, U.S.A.

Dr. Elspeth Smith Dept. of Chemical Pathology University of Aberdeen Medical

Buildings Foresthill Aberdeen, Scotland

Dr.

Dr.

Dr.

Lipid Research Laboratory The Hebrew University Hadassah Medical School Jerusalem, Israel

George Steiner Room 7302, Medical Science

Building Dept. of Medicine University of Toronto Toronto, Ontario, Canada Jack P. Strong Dept. of Pathology Louisiana State University

School of Medicine 1542 Tulane Avenue New Orleans, Louisiana, U.S.A. A. Studer Dept. of Expertmental Medicine F. Hoffman-LaRoche & Co. AG. Grenzacherstrasse 124 Basle, Switzerland

998

Dr. H. J. C. Swan Cedars Sinai Medical Center Box 54265 Medical Advisory Board Los Angeles, California U.S.A.

Dr. C. B. Taylor Veterans Administration

Hospital Albany, New York, U.S.A.

Dr. Wilbur Thomas Dept. of Pathology Union University Albany, New York, U.S.A.

Dr. S. D. Vesselinovitch Dept. of Pathology University of Chicago Chicago, Illinois, U.S.A.

Dr. A. C. Wallace Dept. of Pathology University of Western Ontario London, Ontario, Canada

Dr. K. W. Walton Dept. of Experimental Patho-

logy Rheumatism Research Wing Medical School University of Birmingham Birmingham, England

Dr. G. Weber Instituto Anatomia e Istologia

Patologica Universita di Siena Siena, Italy

Dr. Bernard Weigensberg McGill University Pathology

Institute 3775 University Street Montreal, P.Q., Canada

Dr. A. B. Chandler Eugene Talmadge

Memorial Hospital Medical College of Georgia Augusta, Georgia, U.S.A.

PARTICIPANTS

Dr. H. M. Whyte Dept. of Clinical Science Australian National University Box 4, P.O. Canberra, A.C.T. Australia

Dr. D. R. Wilson Dept. of Surgery Toronto Western Hospital Toronto, Ontario, Canada

Dr. Robert W. Wissler Dept. of Pathology University of Chicago 950 East 59th Street Chicago, Illinois, U.S.A.

Dr. R. Witty Canada Packers Limited 2211 St. Clair Avenue West Toronto, Ontario, Canada

Dr. Stewart Wolf Marine Biomedical Institute 200 University Blvd. Galveston, Texas, U.S.A.

Dr. Bernard M. Wolfe Dept. of Medicine University Hospital London, Ontario, Canada

Dr. Neville Woolf Dept. of Pathology St. George's Hospital Medical

School Hyde Park Corner London, England

Dr. Donald B. Zilversmit Cornell University Graduate

School of Medicine Ithaca, New York, U.S.A.

ADAMS, C.W.M.

AGETA, M.

ALEXANDER, K.M.

ALEXANDER, N.

ALLCOCK, J.M.

ALLEN, D.M.

ANTONUCCI, M.

ARAVANIS, C.

AUGUSTYN, J.M.

AVIGAN, J.

BAHLER, R.C.

BARNETT, H.J.M.

BARN I COAT , K.T.N.

BEAR, R.A.

BEAUMONT, J.L.

BEAUMONT, V.

BECKER, C.G.

BELL, F.P.

BELLON, E.M.

CONTRIBUTORS

999

BERARD, M.

BERENSON, G.S. •• BJORKERUD, S.

BLACKET, R.B.

BLANKENHORN, D.H.

BLOOR, C.M.

BONDJERS, G.

BOWIE, E.J.W.

BOYD, G.S.

BRADBY, H.

BRATTSAND, R.

BRATZLER, R.L.

BRECKENRIDGE, W.C.

BROWN, A.L.

BROWN, H.B.

BUCKLEY, G.

CAMPEAU, L.

CANNON, P.J.

CARLO, I.A.

CARROLL, K.K.

1000

CASARELLA, W.J.

CAZENAVE, J.P.

CHAKRABARTI, R.

CHAMBERLAIN, M.

CHANDLER, A.B.

CHAPPEL, J.E.

CHlU, C.J.

CHRISTIAN, J.C.

CLAIRE, M.

CLARKSON, T.B.

CLIFTON-BLIGH, P.

COLES, J.C.

COLHOUN, J.L.A.

COLTON, C.K.

CONNOR, S.L.

CONNOR, W.E.

CONSTANTINIDES, P.

COOPER, E.E.

COOPER, G.R.

CORCOND !LAS, A.

CORNWELL, D.G.

CSONKA, E.

DAOUD, A.S.

DEGOTT, M.

DELL, R.B.

DePALMA, R.G.

EDWARDS, J.

EGGEN, D.A.

EHNHOLM, C.

ELLIS, K.

ETHERINGTON, M.D.

FALLAT, R.W. FARAH, J.R.

FERGUSON, G.G.

CONTRIBUTORS INDEX

FISCHER-DZOGA, K.

FLETCHER, J.

FRANTZ, 1. D .

FRANZBLAU, C.

FRERICHS, R.R.

FRIEDMAN, R.J.

FRINK, R.J.

FRITZ, K.E.

FUSTER, V.

GEER, J.C.

GERRITY, R.G.

GLAGOV, S.

GLATZ, C.E.

GLUECK, C.J.

GOHDA, H.

GOODMAN, DeW. S.

GOTTO, A.M.

GRASEDYCK, K.

GREENBERG, J.

GRIGOLATO, P.G.

GUCCIONE, M.A.

HAMES, C.

HAMILTON, R.M.G.

HAMPTON, J.R.

HANSSON, G.

HARDY, A.

HAUST, M.D.

HAVEL, R.J.

HAYES, K.C.

HEIMBECKER, R.O.

HEISS, G.

HENRY, P.D.

HEUCK, C.C.

HEWITT, D.

CONTRIBUTORS INDEX

HOAK, J.C.

HOLLANDER, W.

HORLICK, L.

HORNSTRA, G.

HOWARD, A.N.

HUFF, M.W.

HULL, L.

HUTTUNEN, J.K,

IMAI, H.

INNOCENTI, L.

INSULL, W. Jr.

ISAKSSON, B.

JACKSON, R.L.

JACOTOT, B.

JAFFE, E.A.

JAGANNATHAN, S.N.

JAMIESON, S.

JARMOLYCH, J.

JELLINEK, H.

JONES, R.J.

KAKIS, G.

KAMOGAWA, T.

KARIYA, S.

KEKKI, M.

KEON, W.J.

KIM, Y.

KIMURA, N.

KINLOUGH-RATHBONE, R.L.

KIRKPATRICK, J.

KLASSEN, G.A.

KLEIN, L.

KLIMOV, A.N.

KOBAYASHI, M.

KOLETSKY, S.

KOSTUK, W.J.

KOTTKE, B.A.

KOVANEN, P.T.

KRAMSCH, D.M.

KRITCHEVSKY, D.

KUDCHODKAR, B.J.

KUKSIS, A.

KWITEROVICH, P.O., Jr.

L'ABBATE, A.

LANG, P.O.

LAWFORD, P.

LEE, K.T.

LEE, R.

LEE, W.M.

LEELARTHAEPIN, B.

LEWIS, J.C.

LEWIS, L.J.

LINDNER, J.

LITTLE, A.

LOFLAND, H.B.

MADOFF, I.M.

MAHLEY, R.W.

MANNING, G.W.

MARSH, N.A.

MARZILLI, M.

MASERI, A.

MASSARO, T.A.

MASSIE, 1. B.

MAWHINNEY, T.P.

MEADE, T.W.

MELLIES, M.J.

MEYER, W.W.

1001

1002

MICHEL, A.M.

MIETTINEN, T.A.

MIKKELSON, B.

MILDENBERGER, R.R.

MILLER, N.E.

MINICK, C.R.

MISHKEL, M.A.

MITCHELL, J.R.A.

MITCHELL, S.C.

MOORE, S.

MORE, R.H.

MORIYA, K.

MORRISON, E.S.

MUCKLE, T.J.

MULDER, D.S.

MUSTARD, J.F.

MYANT, N.B.

MYHER, J.J.

McDONALD, J.W.D.

McGILCHRIST, C.

McGILL, H.C., Jr.

McGUIRE, V.

McKENZIE, F.N.

NACHMAN, R.L.

NANBU, S.

NEILL, C.A.

NESTEL, P.J.

NICOLOSI, R.J.

NIKKILX, E.A.

NOBLE, R.P.

NORTH, W.R.S.

NORUM, K.R.

NUMANO, F.

CONTRIBUTORS INDEX

O'BRIEN, J.R.

O'DEA, K.

OLSSON, A.G.

OPPLT, J.J.

OSTER, P.

PACKHAM, M.A.

PADDOCK, J.

PALMER, A.J.

PANGANAMALA, R. V.

PARODI, O.

PATELSKI, J.

PAULA, R.K.

PEARSE, R.G.

PENG, S.K.

PESOLA, A.

PETROVA, L.A. ~

PIORUNSKA, M.

PLEET, S.

POCOCK, D.M.E.

POLYAKOVA, E.D.

RADHAKRISHNAMURTHY, B.

RAETZER, H.

RAUTERBERG, J.

REDWOOD, D.R.

REID, W.D.

REIMERS, H.J.

RENAUD, S.

RICHARDSON, M.

ROACH, M.R.

ROBERT, A.

ROBERT, A.M.

ROBERT, L.

ROBERTS, R.

CONTRIBUTORS INDEX

ROBERTSON, A.L.

ROBINSON, H.

RODGER, N.W.

RODRIGUEZ, J.

ROHEIM, P.S.

ROSE, V.

ROSENSTEIN, A.J.

ROSS, A.C.

ROTHBLAT, G.H.

RUDEL, L. L.

RUIZ, C.E.

RUIZ, H.

RYMASZEWSKI, Z.

RYZHENKOV, V.E.

SANGAL, S.P.

SATA, T.

SCANU, A.M.

SCHELLENBERG, B.

SCHETTLER, G.

SCHLIERF, G.

SCHWARTZ, C.J.

SCOTT, R.F.

SESTIER, F.

SHAINHOUSE, Z.

SHAPER, A.G.

SHARMA, H.M.

SHIMAMOTO, T.

SHORLAND, F.B.

SILVERBERG, D.S.

SIMIONESCU, M.

SIMONS, L.A.

SIRTORI, C.R.

SLOWIE, L.A.

SMITH, E.B.

SMITH, F.R.

SMITH, K.A.

SOBEL, B.E.

SODHI, H.S.

SRINIVASAN,

STAMLER, J.

STARY, H.C.

S.R.

ST. CLAIR, R.W.

STEIN, O.

STEIN, Y.

STENDER, S.

STRONG, J.P.

STUART, R.K.

SUBBIAH, M.T.R.

SUSSEX, J.

SWAN, H.J.C.

TAKAHASHI, T.

TAN, M.H.

TAYLOR, C.B.

TEXON, M.

THOMAS, W.A.

TORTORELLI, L.C.

TSANG, R.C.

TURNER, D.

TYROLER, H.A.

VESSELINOVITCH, D.

VOGEL, G.

VOLLMAR, J.

VOST, A.

WALL, W.

WALTON, K.W.

WEBBER, LS.

1003

100.4

WEBER, G.

WEIGENSBERG, B.I.

WEISS, M.B.

WELSH, M.J.

WERTHESSEN, N.T.

WESTMORELAND, N.P.

WHYTE, M.

CONTRIBUTORS INDEX

WISSLER, R.W.

WITTY, R.

WOLFE, B.M.

WOODHILL, J.M;

WOOLF, N.

YAMASAKI, S.

ZEMPLENYI, T. ZILVERSMIT, D.B.

INDEX

Actomysin, localization of, 959-963

Adenosine diphosphate, in thrombus formation, 563

Adipose tissue cholesterol synthesis and

uptake in, 286-288 fatty acid composition of,

283-285 Adolescents, and diet-hyper­

lipoproteinemia relationship, 519-522

Aethirazol, effects of, 479, 481

Age and atherosclerosis in

pigeons, 249-251 and fibrinolytic activity,

219-220 and protocollagen proline

hydroxylase, 758-761 and triglyceride lipase

levels, 147-148 Albumin macroaggregates, and

cerebral perfusion investigation, 328-331

Alpha-lipoproteins See High density lipoproteins

Ambulance service, cardiac­special vs. regular, 134-135

American alternative diet, 843-848

Amino acids (dietary),and plasma cholesterol concentration, 275-277

Anastomoses, and cerebrovascular disease, 332~333

Angina and aortocoronary bypass

surgery, 77-78 myocardial perfusion in,

674-685 Angiography, atherosclerotic

lesion regression and, 435-457, 460, 462, 466, 467

Anticoagulants, and platelet reaction, 96-97

Aorta cholesterol turnover in,

265-267 ganglioside structure in,

164-166 Aortic balloon pumping, and

myocardial infarction, 388-389, 391, 399, 404

Aortocoronary bypass and angina, 77-78 for cardiogenic shock and MI,

394-397, 398 conclusions on, 83-84 definite indications for, 80-81 and quality of life, 76-77 and survival rate, 79-80, 82,83 uncertain indications for,

81-83 Aortotomy, for plaque sampling

and measurement, 462-466 Apolipoproteins, in lipid­

protein proportion, 184-187

1005

1006

Apoproteins classification/role of, 18 synthesis of, 425 See also Specific protein

Arrhythmia, and sudden death, 125

Arterial wall, 865, 867-902 after hypoxia, 324-326 LDL and fibrinogen in,

888-892 lipid accumulation on,

867-870 See also Arterial wall ------permeability; Intima

Arterial wall permeability lipoprotein-transport models

for, 943-950 morphologic basis for,

952-957 Arteriotomy, for plaque

sampling and measurement, 462-466

Aspirin and platelet adherence,

228, 229 and platelet prostaglandin

synthesis, 222-224 and platelets, 97-98

Atherogenesis arterial glycolysis in,

167-170 and muscle relaxant­

endothelial cell relationship, 234-236

and platelet factor 4-like activity, 225-227

See also Atherosclerosis Atherogenic diet, 626

in rhesus monkeys, 603-611 in swine, 597-602 See also Diet

Atherosclerosis animal models for, 576-629 calcification and, 786-791 in childhood, 208-210,

531-536, 850-855 among Cretans, 121-122 current research highlights

in, 9-14

INDEX

Atherosclerosis (cont'd) and endothelial junctions, 39 endothelial permeability in,

969-973 epidemiology of, 505-508 and fibrinolytic activity,

540-544 ganglioside structure in,

164-166 and genetic factors, 494-498 and glycosaminoglycans,

782-785 hemodynamics of, 180-181 and hypertension, 174-176 injury-thrombosis induced,

318-320 lesion progression in, 434-437,

440-444, 471-472 lesion regression in, 437-476 national perspectives on,

808-864 oxidative metabolism in,

272-274 public health approaches on,

803-806 tissue culture in, 707-740 and Von Willebrand's disease,

315-317 See also Specific subjects; ---xtherogenesis; Regression

of atherosclerotic lesions

Australia, atherosclerosis in, 808-814

Australian Academy of Science, 115-117, 808-810

Autoimmune hyperlipidemia, in nephrotic syndrome, 152-153

Autoregulation, and myocardial perfusion, 687-691, 692

Baboon, as experimental model, 593-596

Bacteria, and endothelial endocytosis, 730-736

Balloon-catheter injury, 624 for producing atherosclerosis,

597-602

INDEX

Basal lamina, of arterial endothelial cells, 39-40

Beta-lipoprotiens See Low density - lipoproteins

Beta-sitosterol, in lipid metabolism, 634-635

Bile acid sequestration, 188-193

Blood-artery transfer barrier. and hyper­cholesterolemia, 237-239

Blood pressure age related alterations in,

249-251 and children, 531-532 and fibrinolytic activity,

220, 221 See also Hypertension

Bogalusa Heart Study, 204-207 Britain, coronary heart

disease in, 823-827

Calcification of atherosclerotic lesions

advanced, 790-791 local factors of, 786-787 patterns of, 787-788

Calories, in lipid metabolism, 635-636

Canada atherosclerosis prevention

in, 815-822 polyunsaturated fat intake

in, 856-957 Canaliculi, of endothelial

cells, 37 Capillary endothelium, 966 Carbon monoxide, 972 Cardiogenic shock

and aortic balloon pumping, 388-389, 391

surgery for, 394-397, 398 Catecholamines, 971

and sudden death, 88 Cations, and glycosaminoglycan­

lipoprotein interaction, 155-158

1007

Cattle, genetics of atherosclerosis in, 576, 577, 578

Cephalothin, and platelet adherence, 229

Cerebral perfusion, and isotopic albumin-aggregates, 328-331

Cerebrovascular disease, and microvascular anastomosis, 332-333

Chickens, genetics-atherosclerosis relationship in, 576, 577

Children atherosclerosis risk in, 208-210 cholesterol levels in, 204-207,

209, 210 and diet-hyperlipoproteinemia

relationship, 519 and familial hyper­

cholesterolemia, 212-215 and fatty streaks, 509-512 and "high-risk" category,

507-508, 514-517 prevention of atherosclerosis

in, 850-855 treating hyperlipidemias in,

524-429, 532-539 triglyceride levels in,

204-207 in chylomicron remnant

particles, 139-140 and clofibrate, 65, 66, 71 and dextrothyroxine, 57, 66, 71 and estrogen, 58, 71 and lecithin:cholesterol

acyl transferase, 427-430 in lipid metabolism, 630-634 and niacin, 69, 70, 71 standardizing measurement of,

353-3S5 thrombus uptake of, SS2-SS7 turnover in aorta of, 265-267 See also Cholesterol - ----metabolism; Hyper-

cholesterolemia, Serum cholesterol levels

Cholesterol diet See Atherogenic diet

1008

Cholesterol esters, 878-880 and phospholipids, 882-885 and plasma lipoproteins,

921-926 Cholesterol exchange, evidence

for, 240-242 Cholesterol metabolism, 914

and caloric restriction, 290-293

in endothelial cells of, 244-245

and plasma lipoprotein cholesterol concentrations, 294-296

Cholesterol pool size, and plasma lipoprotein cholesterol concentrations, 294-296

Cholesterol tracking, prediction of, 112

Cholesteryl oleate, 879 metabolism of, 884-885

Cholestyramine compared to polidexide,

188-190 and familial hyper­

cholesterolemia, 212-215

for hyperlipidemia, 650, 657-658, 659

Chondroitin sulfate A, effects of, 480, 481-482

Chylomicrons, 18 and esterified retinal

tracing, 142-144 fate of, 406-409 formation of, 139-140

Cilia, of endothelial cells, 35-36

Clofibrate, 11 for hyperlipidemia, 651,

656-657, 659 and platelets, 99 and post-MI patients, 61, 62,

63, 64, 70, 71 Colchicine, and endothelial

cells, 235, 236 Colestipol hydrochloride,

effects of, 191-193

Collagen, 628 biochemistry of, 774-780 morphology of, 767-773

INDEX

See also Collagen synthesis Collagen synthesis, 733, 758

in aortic medial explants, 928-932

extracellular steps in, 750-754 intracellular biosynthetic

steps in, 774-750 See also Collagen

Collagenase, interaction with glycosaminglycans of, 160-163

Computer, and angiographic assessment, 455-457

Connective tissue, 627 See also Collagen, Elastin

Coronary artery disease lipoprotein distribution diet

relationship in, 195-197 myocardial perfusion in,

693-701 See also Atheroslerosis; - ---COronary heart disease

Coronary Drug Project, 52-72 Coronary heart disease

survival factors in, 116-117 victim profile of, 115-116

Coronary thrombosis, and MI, 87 CPK isoenzymes, and myocardial

infarction, 127-128 Cretans, atherosclerosis among,

121-122 Cytoplasm, of arterial

endothelial cells, 41

Dextrothyroxine, and post-MI patients, 57, 58, 59, 60, 66, 71

Dicumarol, and platelets, 96 Diet

American perspectives on, 843-848

British perspectives on, 824-827

among Cretans, 122 in diet-drug therapy, 644-648

INDEX

Diet (cont'd) and hyperlipidemia

management, 364-369, 519-522

and hyperlipoproteinemia management, 359-363, 370-375

and lipoprotein distribution, 195

Swedish perspectives on. 835-841

See also Atherogenic diet; - --rfutrition

Dietary fat and cholesterol levels,

634-641 and lipid metabolism, 638

Dietary protein, and cholesterol levels. 641-642

Dipyridamole. and platelet survival. 98

DNA, and endothelial cells, 46. 47

DNA synthesis. and lipoproteins, 246-248

Dyslipoproteinemia, lipid­protein proportions in, 184-187

D-thyroxine. for hyperlipidemia. 652

Elastase, interaction with glycosaminglycans of. 160-163

Elastin in aortic medial explants,

928-932 biochemistry of. 774-780 morphology of, 767-773

Electron microscopy, and cultured vascular cells, 712-717

Endocytosis, of endothelial cells, 730-736

Endothelial cells basal laminal aspects of.

39-40 cholesterol metabolism in,

244-245

1009

Endothelial cells (cont'd) culturing techniques for. 719 endocytotic action of, 730-736 function of, 34 and glycocalix, 975-980 inclusions of, 45 and intercellular junctions,

37-39 luminal aspects of. 35-37 organelles of, 41-43 permeability of, 965-968,

969-973 proliferation of, 47 regeneration of. 46 and smooth muscle relaxants,

234-236 vesicles and vacuoles of, 43-44

Epidemiology and atherOSClerosis. 505-508 as science, 504-505

Esterified retinol. tracing chylomicron degradation with. 142-144

Estrogens and platelets. 100 and post-MI patients, SSt, ~.

58 Exercise, 474

in Canadian prevention programs. 816-820

Familial hypercholesterolemia adipose tissue-cholesterol

relationship in, 286-288 and cholestyramine. 212-215

Familial hyperlipoproteinemia. dietary management of. 519-522

Fasting. refeeding and. 300-302 Fatty acids

in adipose tissue, 283-285 and thrombosis, 545-549

Fatty streaks in children, 509-512 evolution of, 603-607 regression of. 607-611

Fibrinogen. in arterial wall. 888-892

Fibrinolytic acitvity and associated variables, 219-221

1010

Fibrinolytic activity (cont'd) and atherosclerotic risk

factors, 540-544 Fibroblasts, cultures of,

724-728 Filaments, of arterial

endothelial cells, 42-43

Flow, and atherosclerotic lesion, 177-179

"Foam cells," 921

Gangliosides, structural characterization of, 164-166

Genetics in animal atherosclerosis

models, 576-590 of hyperlipidemia, 514-517,

532-533 and plasma cholesterol,

494-498 Gerbils, cholesterol metabolism

in, 259-261 Glycocalix

of endothelial cells, 36 hypercholesterolemia and,

975-980 Glycogen, and phenformin.

308-310 Glycogen synthesis, fasting-

. refeeding and, 300-302 Glycolysis (arterial), and

atherogenesis, 167-170 Glycosaminoglycans

in aortic medial explants, 928-932

and arterial permeability~ 171-172

in atherosclerotic lesions, 782-785

interaction with fibrous proteins of, 160-163

interaction with lipoproteins of, 155-158

Golgi complex, of arterial endothelial cells, 41

INDEX

Hemodialysis patients, hyper­lipoproteinemia in, 109-111

Hemodynamics, of atherosclerosis, 180-181, 971-972

Heparin neutralizing activity test and MI, 136-138

Hepatic cholesterogenesis, and injected sterols, 297-299

Hepatic lipase in hypertriglyceridemia,

149-150 in normoglyceridemic subjects,

146-148 High density lipoproteins

origin/fate of, 421-426 See also Lipoproteins

His Bundle, and arrhythmia, 125 Hormones, and platelets, 200 3-hydroxypentanoic acid

derivatives, and cholesterol biosynthesis, 477-478

Hypercholesterolemia and blood­artery transfer barrier, 237-239

cholesterol turnover and metabolism in, 489-492

and chylomicron degradation, 142-144

and endothelial glycocalix, 975-980

genetics of, 514-517 metformin-lipoprotein turnover

relationship in, 269-270 and neomycin, 483-485 and oxidation products of

cholesterol, 252-254 and oxygen consumption, 272-274 and probucol, 485-486 and tissue response to

mechanical injury, 321-323

treating children with, 524-529 See also Cholesterol; Familial ------nypercholesterolemia;

Hyperlipidemia; Serum cholesterol levels

INDEX

Hyperglycemia, cardiac glycogen-phenformin relationship and, 308-310

Hyperlipidemia caloric restriction­

cholesterol metabolism relationship in, 290-293

and calorie intake, 279-282 in children, 532-536 and cholestyramine, 650,

657-658, 659 and clofibrate, 651,

656-657, 659 dietary management of,

364-369 diet-drug therapy for,

644-648 and D-thyroxine, 652 experimental models of,

249-264 genetics of, 514-517 and immunological mechanisms,

262-264 in neonates, 203 and nicotinic acid, 651,

658-659 See also Hypercholesterolemia; --- ~ertryglyceridemia;

Serum cholesterol levels; Tryglyceride levels

Hyperlipoproteinemia dietary management of,

359-363, 370-375 and exercise ST segment

depression, 118-120 fibroblasts in, 724-728 in kidney patients, 109-111 in subhuman primates, 588-590 and tibric acid. 486-487 See also Hypercholesterolemia; - ~erlipidemia,

Hypertryglyceridemia Hypertension

and atherosclerosis, 174-176 and endothelial junctions, 39 public screening for, 182-183

Hypertryglyceridemia and calorie intake, 635 cholesterol turnover and

metabolism in, 489-492 genetics of, 514-517

1011

and immunological mechanisms, 262-264

and lecithin:cholesterol acyl transferase, 430

and polidexide, 188-190 treating children with. 524-529

Hypovolemia, and sudden death, 90 Hypoxia, arterial surface changes

after. 324-326

Immunological mechanisms and hyperlipidemia, 262-264 and intracellular matrix, 762

Immunoperoxidase technique, 959-963

Infarct extension. 401-402 Intima

plasma macromolecule accumulation in. 872-874

plasma macromolecule deposition in, 874.875

See also Arterial wall Intracellular matrix

macromolecules, pathophysiology of, 762-765

Iproveratril, and endothelial cells, 235, 236

Ischemic heart disease aortocoronary bypass surgery

and, 76-84 See also Myocardial infarction

Learning, 190-200 Lecithin: cholesterol

acyl transferase and cholesterol transport,

427-430 and standardization, 356-357

Lidocain, 598 Linoleic acid. and thrombosis,

546-549 Lipid clinics

objectives of, 347-348 organization of, 349-351

1012

Lipid Metabolism beta-sitosterol in, 634-635 cholesterol and, 630-634 and dietary fat, 635, 638 and diet-drug therapy,

644-648 Lipids

in lipid-protein proportion, 184-187

See also Cholesterol; - ---cIpid metabolism;

Tryglycerides Lipogenesis, fast-refeeding

and, 300-302 Lipoprotein electrophoresis,

standardization of, 356

Lipoprotein lipase, 865 in hypertriglyceridemia,

149-150 in normoglyceridemic

subjects, 146-148 in skeletal muscle, 306-307 as atherogenesis cause, 10 cholesterol concentrations

in, 294-296 and cholesterol

esterification, 921-926 dietary cholesterol effects

on, 256-258 and distribution-diet

relationship, 195-197 and DNA synthesis, 246-248 interaction with

glycosaminoglycan of, 155-158

and metformin, 269-270 in plaque formation, 793-799 recent physiological

developments reviewed, 16-23

recent structural developments in, 23-29

and smooth muscle cells, 764-765, 903-907, 915-920

and ST segment depressions, 118-120

transport through endothelium of, 43-44

INDEX

Lipoprotein lipase (cont'd) See also Hyperlipoproteinemia

LoW"Calorie diet cholesterol metabolism in,

290-293 and hyperlipidemia, 279-282

Low density lipoproteins in arterial wall, 888-892 and arterial-wall permeability,

943-950 in intima, 873-876 origin/fate of, 413-418 See also Lipoproteins

Lysolecithin acyl transferase , activity of, 303-305

Mechanical injury as atherosclerosis cause,

318-320 hypercholesterolemia-tissue

response relationship and, 321-323

Membrane oxygenator, 400 and myocardial infarction, 390,

391-392 in open heart surgery, 337-338

Metformin, and lipoprotein turnover, 269-270

Mice, genetics of atherosclerosis in, 580-581

Microvilli, of endothelial cells, 35

Mother's milk, and plasma cholesterol concentration, 588

Multiple-crystal scintillation camera, and perfusion, 693-701

Multivesicular body, of endothelial cells, 44-45

Mural coronary thrombosis, and sudden death, 124-125

Myocardial infarction adipose-tissue fatty acid

composition and, 283-285 and aortic balloon pumping,

388-389, 391 and bypass surgery, 83 and clofibrate, 61, 62, 63, 64,

70, 71

INDEX

Myocardial infarction (cont'd) and coronary thrombosis, 87 and CPK isoenzymes, 127-128 and dextrothyroxine, 57, 58,

59, 60, 66, 71 and estrogen, 55, 56, 58 and heparin neutralizing

activity test, 136-138 and membrane oxygenator,

390, 391-392 and niacin, 67, 68, 69,

70, 71 overview of therapeutic

developments for, 376-378

size of, 383-387 surgery for, 394-397, 398,

399-400 and vasodilators, 380-382 and ventricular-septal­

defect repair, 335-336 Myocardial perfusion, 687-706

in angina patient, 674-685 geographic regional

differences in, 691-692 microscopic determinants of,

687-691 overview of, 668-671 and radiolabelled particles,

130-133 regional measurement of,

693-70'1

National Heart Foundation of Australia, 810

National Heart Foundation of New Zealand, 828

Neomycin, and hypo­cholesterolemia, 480-482

Neonatal period, intralipid infusions in, 201

Nephrotic syndrome, autoimmune hyperlipidemia in, 152-153

New Zealand, prevention perspectives in, 828-832

Niacin, and post-MI patients, 67, 68, 69, 70, 71

1013

Nicotinic acid, 11 for hyperlipidemia, 651, 658

Nitroglycerin, and myocardial infarction, 380, 399-400, 405

Nucleus, of arterial endothelial cells, 41

Nutrition in lipid metabolism, 630-636,

661-667 See also Diet

Obese subjects, cholesterol metabolism in, 290-293

Open heart surgery, and membrane oxygenator, 337-338

Ophthalmic calipers, for plaque measurement, 462

Organelles, of endothelial cells, 41-43

Oxidation products, of cholesterol, 252-254

Oxidative metabolism, in atherosclerosis, 272-274

7-oxo-cholesterol, and heaptic cholesterogenesis, 297-299

Parmidin, effects of, 479, 481 Patent graft, and bypass

surgery, 78, 79 Penicillin G, and platelet

adherence, 229 Permeability

endothelial, 965-968, 969-973 See Arterial wall permeability

Phagocytosis, and lesion regression, 446

Phenformin, and cardiac glycogen, 308-310

Phenotyping of lipoproteins, 16, 357

Phenylephrine, and nitroglycerin­MI relationship, 380, 381, 382, 399-400, 405

Phospholipids, and cholesterol ester metabolism, 882-885

Phthalazinol, and endothelial cells, 235, 236

1014

Pigeons, genetics of atherosclerosis in, 582-584, 585

Plant sterol, and hepatic cholesterogenesis, 297-299

Plaque and connective tissue,

771-773 lipoproteins in formation

of, 793-799 and mural thrombosis,

558-562 Plasmin, and platelet survival,

231-232 Platelet factor 4-1ike

activity, and atherogenesis, 225-227

Platelets and adhesiveness­

atherosclerosis relationship, 315-317

and arrhythmia, 88-90, 125 drugs and, 96-99, 100 and heparin neutralizing

activity text, 136-138 modifying survivial of,

231-232 in thrombi formation, 94-96,

99, 563-566 vessel-wall adherence,

228-229 POlidexide, metabolic effects

of, 188-190 Polyunsaturated fats, in

American/Canadian diets, 856-857

Post-heparin plasma lipolytic activity, 13, 356

Primates compared to rabbits, 614-619 genetics of atherosclerosis

in, 584-590 See also Subhuman primates

Probucor;-and hypercholesterolemia, 485-486

Prostaglandin synthesis, and antiinflammatory drugs, 222-224

Prostaglandins, and platelet aggregation, 89-90

Proteins (dietary)

INDEX

and plasma cholesterol levels, 275-277

See also Lipoproteins Protocollagen proline hydroxylase,

and collagen synthesis, 758-761

Public health and atherosclerosis prevention,

803-864 and hypertension screening,

182-183 pyridinolcarbamate, 235, 236, 476

Rabbits compared to primates, 614-619 genetics of atherosclerosis in,

581-582 Race

and atherosclerosis, 505-506 cholesterol-triglyceride

levels and, 205-207 and fibrinolytic activity, 219

Radio1abel1ed particles, and myocardial-perfusion assessment, 130-133

Rats, genetics of atherosclerosis in, 578-580

Refeeding, fasting and, 300-302 Regression of atherosclerotic

lesions, 432-476 angiogram assessment of,

453-457, 460, 466, 467 in complicated lesions, 447-451 factors in, 437-438 and low lipid diet, 444-445 in rhesus monkeys, 607-611,

618-619 sampling and observation

methods and, 460-469 slow or absent, 445-446

"Remnant" particle, 20 Renal flow, and sudanophilic

lesion, 177-179 Renal transplant recipients,

hyperlipoproteinemia in, 109-111

INDEX

Reserpine, and platelet adherence, 229

Rhesus monkey fatty streak in, 603-610 See also Subhuman primates

Sacrifice, arterial segment procurement at, 466

Scanning electron microscopy, 713-715, 716

and arterial surface changes, 324-326

Science, types of, 504-505 Scintigrams, and angina

patients, 676, 680-685 Selective arterialization, of

coronary veins, 340-341 Serum cholesterol levels

with arterial thrombosis, 557 in children, 204-207, 209,

210 and cho1estipol

hydrochloride, 191-193 and coronary men, 116 and dietary fats, 278,

638-641 education for reduction of,

198-200 and endothelial permeability,

972-973 family/twin studies on,

494-498 and fibrinolytic acitivty,

220, 221 and polidexide, 188-190 prediction of, 112 and proteins (dietary),

275-277, 641-642 and weight loss, 216-218 See also Cholesterol; - ~ercholesterolemia

Sex, and triglyceride lipase levels, 147-148

Skeletal muscle, lipoprotein lipase in, 306-307

Smoking in Canadian prevention

program, 818-819 and coronary men, 115

1015

Smoking (cont'd) and fibrinolytic activity, 221 and platelet function, 99 in Swedish perspective, 841

Smooth muscle cells on arterial wall, 867-870 lipoprotein-cholesterol ester

relationship in, 921 lipoprotein uptake by, 903-907 lipoproteins in metabolism of,

909-913 lipoprotiens in proliferation

of, 915-920 Smooth muscle relaxants, and

hyperactive endothelial cells, 234-236

Squalene, 502 Squirrel monkeys

genetics of atherosclerosis in, 584-588

See also Subhuman primates ST segment depressions, and

lipoproteins, 118-120 Standardization, of biochemical

procedures, 353-357 Sterol accumulation, age-related

alterations in, 249-251 Sterols, and hepatic

cholesterogenesis, 297-299

Stress, and platelet aggregation, 100

Subhuman primates compared to rabbits, 614-619 fatty-streak u1trastructures

of, 311-314 genetics of atherosclerosis in,

584-590 as human disease models,

256-258 Sudanophilic lesion, and renal

flow, 177-179 Sudden death

and hypovolemia, 90 and mural coronary thrombosis,

124-125 overview of, 91 without coronary thrombosis or

MI, 87-91

1016

Sudoxicam, 98 Sulfinpyrazone

and platelet adherence, 228, 229

and platelet function, 97-98 and platelet prostaglandin

synthesis, 222-224 Supra-iliac skinfold thickness,

and fibrinolytic activity, 220, 221

Surgical techniques and membrane oxygenator,

337-338 and microvascular

anastomosis, 332-333 and selective

arterialization, 340-341

and ventricular-septal­defect repair, 335-336

Sweden, and atherosclerosis, 834-842

Swine, as atherosclerosis model, 597-602

"Teflo," 337-338 Thrombin, and platelet

survival, 231, 232 Thrombocytopenia, 98-99 Thrombosis

as atherosclerosis cause, 318-320

and dietary fatty acids, 545-549

in plaque growth, 558-562 and platelets, 94-96, 99 See also Thrombus

Thromb~ cholesterol uptake by,

552-557 dynamics of formation of,

563-566 Tibric acid, 501

effects of, 486-487 Tissue culture, 708-740

for arterial endothelial cells, 719-723

and electron microscopy, 712-717

of endothelial cells, 730-736

Tissue culture (cont'd) future of, 710-711

INDEX

of human fibroblasts, 724-728 problems of, 708-710

Transmission electron microscopy, 715-716

and arterial surface changes, 324-326

Triglyceride levels in children, 204-207 and coronary men, 116 and dietary fats, 278 and fibrinolytic activity,

220, 221 and weight loss, 216-218 See also Trig1ycerides

Tryg1ycerides in chylomicron remnant

particles, 139-140 and clofibrate, 65, 66, 71 and dextrothyroxine, 57, 66, 71 and estrogen, 58, 71 and neonates, 203 and niacin, 69, 70, 71 standardizing measurement of,

355-356 tracing with esterified

retinol, 142-144 See also Triglyceride levels

Tropomyosin, localization of, 959",963

Twin studies, and plasma cholesterol, 494-498, 502-503

Ultracentrifugation, standardization of, 356

Vacuole, of endothelial cells, 44 Vascular cells, electron

microscopic techniques and, 712-717

Vasodilators, for myocardial infarction, 380-382, 399, 400, 405

Ventricular septal defect, surgical repair of, 335-336

Venu1es, 967

INDEX

Very low density lipoproteins, 18

origin/fate of, 406-409 See also Lipoproteins

Vesicl~on endothelial cells, 43-44

Vinblastine, and endothelial cells, 235, 236

Viral myocarditis, and sudden death, 88

Viruses, 736 von Wi11ebrand's disease, and

atherosclerosis, 315-317

1017

Weibel-Palade bodies, of arterial endothelial cells, 41-42

Weight, and cholesterol synthesis, 491

Weight gain, and hyper1ipidaemia, 216-218

West Germany, coronary heart disease in, 9-10

Women, and fibrinolytic activity, 219

Xenon, and perfusion measurement, 693-701