Why you need this App

Sean Ekins1, Alex M. Clark2

1 Collaborations in Chemistry, 5616 Hilltop Needmore Road, Fuquay Varina, NC 27526, U.S.A.2 Molecular Materials Informatics, 1900 St. Jacques #302, Montreal, Quebec, Canada H3J 2S1.

Why you need this App

• What if you need to find out about the latest news on a neglected or rare disease fast

• What if you are tired of the status quo and want to do rare and neglected disease research differently

• What if you want to share your ideas with the world

• Where do you go?

• Look no further – you are about to find out the solution

• http://tinyurl.com/6l9qy4f

1. Intro

• What is a rare disease?

• How do parents or patients find out about a disease?

Commonalities

• Both neglected and rare disease research have a problem

• Too many diseases without cures• Too little money to go around• Too little collaboration• Too many people dying and suffering• Long term cost to mankind is immense

• How could scientists collaborate on rare or neglected diseases?

• Enter – Open Drug Discovery Teams – the first free mobile app for rare and neglected disease information

http://tinyurl.com/6l9qy4f

2. Why not create an app?

• Can we connect researchers and patients?• Can we create Open Drug Discovery Teams• How do we bring information on diseases to

the people that need it• Can we centralize the data that matters?• Bring social media into rare diseases

3. What influenced design?

• Simple user friendly design concept• Flipping through topics, big buttons, easy to

see on phone and app• Crowdsourcing – use feedback to vote on

topics• Why is there no Flipboard for Science?

9 Panels includes one on ODDT information

Can use multiple Twitter accounts Here is my icon

Stats summary

About App

4. Topics

• We picked topics we had an interest in scientifically

• We picked topics suggested by parents of children with rare diseases

• We picked topics we felt could benefit from open sharing of data

• We picked topics that needed a new way of thinking

Disease Topics

• Sanfilippo Syndrome• Giant Axonal Neuropathy• Tuberculosis• Malaria• Chagas Disease• Leishmaniasis• Huntingtons Disease• HIV/AIDS• H5N1 flu

Other Topics

• Drug Repurposing– News on FDA approved drugs that can be used for

diseases other than those they were originally intended for

– Faster way to cure diseases?• Green Chemistry– Make chemical synthesis better for the

environment– Use safer chemicals to find cures for diseases

5. How to use the app• Use it to publish links to your blogs on the topic• Publish your chemistry, Structure activity data that could help

others• Use it to raise awareness of a new paper• Parents / researchers can find out about the disease – what is

current, what has published• Use it to collaborate openly – an open labnotebook• You can curate the data – vote on what matters to you• Share the important findings• Use it for inspiration that crosses diseases and topics• Get rare and neglected disease researchers to use green

chemistry.

6. What can it do?

• Collects Twitter feeds on hashtags for topics• Collects Google Alerts on topics• Allows you to see tweets of molecules and

structure activity data• If you contribute to a topic you are visible in

the app• It can track your contributions to topics• All of the above happens in one App

Click here to endorse or disapprove

Click here to follow hyperlink

Look at a topic and see the content

Endorse or disapprove content

Look at endorsed content

See molecules in the appClick on image to open it

Ranked content

Interact with other Apps

Find Structure activity relationship data that is published for diseases

Stats summary

7. Future

• The App becomes a “notebook” for science• Integrate other data sources• PubMed, Google Scholar etc• Add annotation around diseases• Becomes a database of chemistry and biology

data around the diseases that is open• Link to tools that enable drug discovery by

anyone

8. Why we need funding

9. Vision 4 future

10. Acknowledgments

• Antony Williams, RSC