whole foods and nutrition

Presented by Glen GillardPresented by Glen Gillard

DIP N.T. [Gov Accred] C.E.C.H. Ird. M.C.M.ADIP N.T. [Gov Accred] C.E.C.H. Ird. M.C.M.A..

Whole Foods and Nutrition:Whole Foods and Nutrition: Tools for the Practicing Tools for the Practicing

Kinesiologist in the FutureKinesiologist in the Future’’

GlucosinolatesGlucosinolates““The phenomenal active in certain The phenomenal active in certain

super foods that prevents, treats super foods that prevents, treats and can help beat a variety of and can help beat a variety of chronic conditions”chronic conditions”

Broccoli: Anticancer KingBroccoli: Anticancer King““The consumption of cruciferous vegetables The consumption of cruciferous vegetables

has been associated with a reduced risk has been associated with a reduced risk of cancer of the lung, stomach, colon and of cancer of the lung, stomach, colon and rectum. The health benefits of rectum. The health benefits of cruciferous vegetables such as broccoli, cruciferous vegetables such as broccoli, Brussels sprouts, cabbage, and bok choy Brussels sprouts, cabbage, and bok choy have been attributed to their high have been attributed to their high concentration of glucosinolates. The concentration of glucosinolates. The chemoprotective effect of indol-3-chemoprotective effect of indol-3-carbinol, a constituent of these carbinol, a constituent of these vegetables, has been shown to have vegetables, has been shown to have chemopreventive effects.”chemopreventive effects.”

Heber D. Vegetables, fruits and phytoestrogens in the prevention of diseases. J Postgrad Med 2004;50:145-Heber D. Vegetables, fruits and phytoestrogens in the prevention of diseases. J Postgrad Med 2004;50:145-4949

Broccoli: Anticancer KingBroccoli: Anticancer King

““Isothiocyanates (found in Broccoli) act as anti-Isothiocyanates (found in Broccoli) act as anti-carcinogens by inducing Phase II conjugating carcinogens by inducing Phase II conjugating enzymes, in particular Glutathion S-enzymes, in particular Glutathion S-tranferases.”tranferases.”


Broccoli Sprouts: An Broccoli Sprouts: An Exceptional SourceExceptional Source

““Unexpectedly, 3-day-old sprouts of cultivars of Unexpectedly, 3-day-old sprouts of cultivars of certain crucifers including broccoli and certain crucifers including broccoli and cauliflower contain 10-100 times higher cauliflower contain 10-100 times higher levels of glucoraphanin levels of glucoraphanin

(the glucosinolate of (the glucosinolate of

sulforaphane) than dosulforaphane) than do

the corresponding mature the corresponding mature

plants.”plants.”

Jed W. Fahey, Yuesheng Zhang, and Paul Talalay. Broccoli sprouts: An exceptionally rich source of inducers Jed W. Fahey, Yuesheng Zhang, and Paul Talalay. Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. of enzymes that protect against chemical carcinogens. Proc. Natl. Acad. Sci. USAProc. Natl. Acad. Sci. USA Vol. 94, pp. 10367- Vol. 94, pp. 10367-10372, September 1997 10372, September 1997


““Extracts of 3-day-old broccoli sprouts Extracts of 3-day-old broccoli sprouts (containing either glucoraphanin or (containing either glucoraphanin or sulforaphane as the principal enzyme sulforaphane as the principal enzyme inducer) were highly effective in reducing inducer) were highly effective in reducing the incidence, multiplicity, and rate of the incidence, multiplicity, and rate of development of mammary tumors in development of mammary tumors in dimethylbenz(dimethylbenz(aa)anthracene-treated rats.”)anthracene-treated rats.”



““Dramatic quantitative differences between Dramatic quantitative differences between the inducer potencies of young sprouts the inducer potencies of young sprouts and mature crucifers grown from the same and mature crucifers grown from the same seed lots are associated with equally seed lots are associated with equally striking qualitative and quantitative striking qualitative and quantitative differences in the glucosinolate profiles of differences in the glucosinolate profiles of these plants.”these plants.”


Sulforaphane from Broccoli Sulforaphane from Broccoli Causes G2/M Cell ArrestCauses G2/M Cell Arrest

““Previously, we showed that sulforaphane Previously, we showed that sulforaphane (SFN), a naturally occurring cancer (SFN), a naturally occurring cancer chemopreventive agent, effectively inhibits chemopreventive agent, effectively inhibits proliferation of PC-3 human prostate cancer proliferation of PC-3 human prostate cancer cells by causing caspase-9 and caspase-8-cells by causing caspase-9 and caspase-8-mediated apoptosis. Here, we demonstrate mediated apoptosis. Here, we demonstrate that SFM treatment causes an irreversible that SFM treatment causes an irreversible arrest in the G(2)/M phase of the cell cycle.”arrest in the G(2)/M phase of the cell cycle.”

Singh SV, Herman-Antosiewicz A, Singh AV, Lew KL, Srivastava SK, Kamath R, Brown KD, Zhang L, Singh SV, Herman-Antosiewicz A, Singh AV, Lew KL, Srivastava SK, Kamath R, Brown KD, Zhang L, Baskaran R. Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated Baskaran R. Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cyle 25c. J Biol Checm. 2004 Jun11:279(24):25813-22. Epub 2004 April phosphorylation of cell division cyle 25c. J Biol Checm. 2004 Jun11:279(24):25813-22. Epub 2004 April 0808

Sulforaphane from Broccoli Sulforaphane from Broccoli Causes G1 Cell ArrestCauses G1 Cell Arrest

““We demonstrated that sulforaphane arrested We demonstrated that sulforaphane arrested cell-cycle progression in G1 phase by a cell-cycle progression in G1 phase by a significant down-modulation of cyclin D3. significant down-modulation of cyclin D3. Moreover, sulforaphane induced apoptosis Moreover, sulforaphane induced apoptosis (and also necrosis), mediated by an increase in (and also necrosis), mediated by an increase in the expression of p53, whereas it exerted little the expression of p53, whereas it exerted little effect on bcl-2 and bax levels. These finding effect on bcl-2 and bax levels. These finding indicate that sulforaphane can exert protective indicate that sulforaphane can exert protective effects inhibiting leukemic cell growth.”effects inhibiting leukemic cell growth.”

Fimognari C, Nusse M, Berti F, Iori R, Cantelli-Forti G, Hrelia P. Sulforphane modulates cell cycle and Fimognari C, Nusse M, Berti F, Iori R, Cantelli-Forti G, Hrelia P. Sulforphane modulates cell cycle and apoptosis in transformed and non-transformed human T lymphocytes. Ann N Y Acad Sci. 2003 apoptosis in transformed and non-transformed human T lymphocytes. Ann N Y Acad Sci. 2003 Dec;1010:393-8Dec;1010:393-8

Isothiocyantes from BroccoliIsothiocyantes from BroccoliPromote DetoxificationPromote Detoxification

““Plants of the family Brassicaceae contain Plants of the family Brassicaceae contain high levels of glucosinolates. The latter high levels of glucosinolates. The latter compounds are degraded to compounds are degraded to isothiocyanates, some of which have been isothiocyanates, some of which have been shown to be potent inducers of phase II shown to be potent inducers of phase II detoxification enzymes in vitro.”detoxification enzymes in vitro.”

Munday R, Munday CM. Induction of phase II detoxification enzymes in rats by plant-derived isothiocyanates: Munday R, Munday CM. Induction of phase II detoxification enzymes in rats by plant-derived isothiocyanates: comparison of allyl isothiocyanate with sulforphane and related compounds. J Agric Food Chem. 2004 comparison of allyl isothiocyanate with sulforphane and related compounds. J Agric Food Chem. 2004 Apr 7;52(7);1867-71.Apr 7;52(7);1867-71.

Isothiocyantes from BroccoliIsothiocyantes from BroccoliCause Decreased Cancer Cause Decreased Cancer

GrowthGrowth““Taken together, our findings suggest that Taken together, our findings suggest that

selected ITCs can rapidly initiate growth selected ITCs can rapidly initiate growth inhibition of cancer cells by simultaneously inhibition of cancer cells by simultaneously modulating multiple cellular targets, and modulating multiple cellular targets, and their antiproliferative activity may be their antiproliferative activity may be largely unaffected by their metabolism and largely unaffected by their metabolism and disposition in vivo.”disposition in vivo.”

Zhang Y, Tang L, Gonzalez V. Selected isothiocyantes rapidly induce growth inhibition of cancer cells. Mol Zhang Y, Tang L, Gonzalez V. Selected isothiocyantes rapidly induce growth inhibition of cancer cells. Mol Cancer Ther. 2003 Oct;2(10):1045-52Cancer Ther. 2003 Oct;2(10):1045-52

Glycomax LactoferrinGlycomax Lactoferrin

““Glycomax Lactoferrin is a bioactive Glycomax Lactoferrin is a bioactive glycoprotein (containing 689 amino glycoprotein (containing 689 amino acids) found in the whey protein acids) found in the whey protein fraction of bovine milk. Lactoferrin is fraction of bovine milk. Lactoferrin is also found in human colostrum, breast also found in human colostrum, breast milk, tears, synovial fluid, seminal milk, tears, synovial fluid, seminal plasma and saliva. plasma and saliva.

It has been suggested that Lactoferrin It has been suggested that Lactoferrin plays a role in supporting and plays a role in supporting and complementing the human immune complementing the human immune system.” system.”

Australian Dairy ProteinsAustralian Dairy Proteins

LactoferrinLactoferrin

““Bovine and human lactoferrin was Bovine and human lactoferrin was shown to inhibit growth of human cell shown to inhibit growth of human cell carcinomas transplanted in mice.”carcinomas transplanted in mice.”

Tsuda H, Ohshima Y, Nomoto H, Fujita K, Matsuda E, Iigo M, Takasuka N, Moore. Cancer prevention by Tsuda H, Ohshima Y, Nomoto H, Fujita K, Matsuda E, Iigo M, Takasuka N, Moore. Cancer prevention by natural compounds. Drug Metab Pharmacokinet. 2004 Aug;19(4):245-63natural compounds. Drug Metab Pharmacokinet. 2004 Aug;19(4):245-63

Mechanisms of Lactoferrin Chemopreventative Mechanisms of Lactoferrin Chemopreventative Effects.Effects.

(Source as per previous slide)(Source as per previous slide)

Oncogene |

CellProliferation

CellDifferentiation

ApoptosisModification

Of Phase1 Enzyme

AntiAngiogenesis

AntiHormone

AntiInflammatory

Immune Enhancing

Anti Oxidant

Prevention

LactoLactoForte Forte Designed to Activate the Designed to Activate the

SystemSystem

LactoForte is designed to activate LactoForte is designed to activate the system LactoForte includes the system LactoForte includes ingredients such as LactoFerrin, ingredients such as LactoFerrin, Broccoli Sprout Powder and Broccoli Sprout Powder and Bovine Trachael Cartilage. Bovine Trachael Cartilage.

When the job needs a heavy duty When the job needs a heavy duty functional food, this complete functional food, this complete nutritional package of high nutritional package of high biological protein, biological protein, phytochemicals, lignans and phytochemicals, lignans and naturally occurring naturally occurring glyconutrientsglyconutrients, is one of the best , is one of the best fuels to fuels to prevent engine failureprevent engine failure. .

LactoForte may support the body LactoForte may support the body during periods of convalescence during periods of convalescence and help reduce the side effects of and help reduce the side effects of chemicals.chemicals.

Ingredients: Bovine tracheal cartilage, Fermented rice bran, Broccoli sprout powder, Supergreens, Spirulina powder, beetroot powder, Beta Glucan 1’3/1’6, Maca root powder, Taurine, Lacto-Ferrin, L-Lysine, Alfalfa powder, Calcium ascorbate, Quercitin, Magnesium aspartate, L-Glutamine, Blueberry powder, Hesperidin 98%, Milk Thistle powder, Aloe vera powder, Folic acid powder, C88 activated quartz meal.

Alfalfa SproutsAlfalfa Sprouts““Studies in humans, animals and cell culture Studies in humans, animals and cell culture

systems suggest that dietary phytoestrogens systems suggest that dietary phytoestrogens play an important role in prevention of play an important role in prevention of menopausal symptoms, osteoporosis, menopausal symptoms, osteoporosis, cancer and heart disease. Broadly defined, cancer and heart disease. Broadly defined, phytoestrogens include isoflavones, phytoestrogens include isoflavones, coumestans, and lignans. Alfalfa sprouts, coumestans, and lignans. Alfalfa sprouts, soybeans, clover and oilseeds (such as soybeans, clover and oilseeds (such as flaxseed) are the most significant dietary flaxseed) are the most significant dietary sources of isoflavones, coumestans, and sources of isoflavones, coumestans, and lignans, respectively. A number of these lignans, respectively. A number of these compounds have been identified in fruits, compounds have been identified in fruits, vegetables and whole grains commonly vegetables and whole grains commonly consumed by humans. consumed by humans. .”.”

A News Extract from the Annual Review of Nutrition, 17:353-381 1997,DIETARY PHYTOESTROGENS A News Extract from the Annual Review of Nutrition, 17:353-381 1997,DIETARY PHYTOESTROGENS Kurtzer MS, Xu X Kurtzer MS, Xu X

Vitamin K: Mechanisms of Vitamin K: Mechanisms of ActionAction

““The growth inhibitory and cytotoxic effects The growth inhibitory and cytotoxic effects of vitamin K have been demonstrated both of vitamin K have been demonstrated both in vivo in vivo and and in vitroin vitro, yet the mechanisms of , yet the mechanisms of action remain unclear. A number of action remain unclear. A number of mechanisms have been proposed and the mechanisms have been proposed and the dominant model has focused on the dominant model has focused on the oxidative capacity of vitamin K analogues oxidative capacity of vitamin K analogues such as menadione.”such as menadione.”

Lamson DW, Plaza SM. The anticancer effects of Vitamin K. Altern Med Rev. 2003 Aug;8(3):303-18Lamson DW, Plaza SM. The anticancer effects of Vitamin K. Altern Med Rev. 2003 Aug;8(3):303-18


““Supporting this theory is the observation Supporting this theory is the observation that menadione increased oxidative stress that menadione increased oxidative stress in malignant cells. Oxidative stress was in malignant cells. Oxidative stress was detected by increased DNA strand breaks detected by increased DNA strand breaks due to hydroxyl radicals produced by the due to hydroxyl radicals produced by the presence of menadione in the MCF-7 cell presence of menadione in the MCF-7 cell culture.”culture.”



““The oxidative stress produced by K3 can The oxidative stress produced by K3 can begin a cascade of events leading to the begin a cascade of events leading to the characteristic signs of apoptosis, cell characteristic signs of apoptosis, cell shrinkage, DNA fragmentation, and shrinkage, DNA fragmentation, and activation of capsase-3.”activation of capsase-3.”


Vitamin K: Mechanisms of Vitamin K: Mechanisms of Action – Cell Cycle ArrestAction – Cell Cycle Arrest

““The ability of vitamin K to induce cell cycle The ability of vitamin K to induce cell cycle arrest and cell death may also be explained by arrest and cell death may also be explained by the inhibition of protein kinases in association the inhibition of protein kinases in association with a cyclin-dependent mechanism.”with a cyclin-dependent mechanism.”


Diindolylmethane (DIM)Diindolylmethane (DIM)

““A number of mechanisms exist whereby DIM A number of mechanisms exist whereby DIM can diminish the effects of estrogen on tumor can diminish the effects of estrogen on tumor growth. First, DIM induces enzymes such as growth. First, DIM induces enzymes such as CYP1A1, which converts estrone to 2-CYP1A1, which converts estrone to 2-hydroxyestrone and ultimately results in hydroxyestrone and ultimately results in metabolites that are antiproliferative and metabolites that are antiproliferative and proapoptotic .”proapoptotic .”

Indole-3-carbinol is a negative regulator of estrogen. Auborn KJ, Fan S, Rosen EM, Goodwin L, Indole-3-carbinol is a negative regulator of estrogen. Auborn KJ, Fan S, Rosen EM, Goodwin L, Chandraskaren A, Williams DE, Chen D, Carter TH J Nutr. 2003 Jul;133(7 Suppl):2470S-2475S Chandraskaren A, Williams DE, Chen D, Carter TH J Nutr. 2003 Jul;133(7 Suppl):2470S-2475S

Folate Prevents Colorectal Folate Prevents Colorectal CancerCancer

““Folic acid deficiency in humans has been Folic acid deficiency in humans has been linked with megaloblastic anaemia, linked with megaloblastic anaemia, neural tube defects in the neonate, and neural tube defects in the neonate, and heart disease. Folate has also been heart disease. Folate has also been implicated in the development of cancer, implicated in the development of cancer, especially cancer of the colorectum. ”especially cancer of the colorectum. ”

Duthie SJ. Folic acid deficiency and cancer: mechanisms of DNA instability. Br Med Bull. 1999;55(3):578-92 Duthie SJ. Folic acid deficiency and cancer: mechanisms of DNA instability. Br Med Bull. 1999;55(3):578-92

Folate Prevents Cancer: Folate Prevents Cancer: MechanismsMechanisms

““There appear to be two principal There appear to be two principal mechanisms through which low folate mechanisms through which low folate status may increase the risk of status may increase the risk of malignancy. Folate deficiency, by reducing malignancy. Folate deficiency, by reducing intracellular S-adenosylmethionine (SAM), intracellular S-adenosylmethionine (SAM), can alter cytosine methylation in DNA, can alter cytosine methylation in DNA, leading to inappropriate activation of proto-leading to inappropriate activation of proto-oncogenes and induction of malignant oncogenes and induction of malignant transformation . ”transformation . ”


Folate Prevents Cancer: Folate Prevents Cancer: MechanismsMechanisms

““Alternatively, folic acid is crucial for normal Alternatively, folic acid is crucial for normal DNA synthesis and repair. Folate DNA synthesis and repair. Folate deficiency may cause an imbalance in deficiency may cause an imbalance in DNA precursors, uracil misincorporation DNA precursors, uracil misincorporation into DNA, and chromosome breakage. ”into DNA, and chromosome breakage. ”



““Folate is crucial for normal DNA Folate is crucial for normal DNA methylation, synthesis and repair, and methylation, synthesis and repair, and deficiency of this nutrient is hypothesized deficiency of this nutrient is hypothesized to lead to cancer through disruption of to lead to cancer through disruption of these processes. There is some evidence these processes. There is some evidence to suggest that relatively high dietary folate to suggest that relatively high dietary folate intake might be associated with reduced intake might be associated with reduced colorectal cancer risk . ”colorectal cancer risk . ”Terry P, Jain M, Miller AB, Howe GR, Rohan TE. Dietary intake of folic acid and colorectal cancer risk in a Terry P, Jain M, Miller AB, Howe GR, Rohan TE. Dietary intake of folic acid and colorectal cancer risk in a

cohort of women. Int J Cancer. 2002 Feb 20;97(6):864-7.cohort of women. Int J Cancer. 2002 Feb 20;97(6):864-7.


““Overall, our data lends some support to the Overall, our data lends some support to the hypothesis that high folate intake is hypothesis that high folate intake is associated with a reduced risk of associated with a reduced risk of colorectal cancer . ”colorectal cancer . ”

Terry P, Jain M, Miller AB, Howe GR, Rohan TE.Dietary intake of folic acid and colorectal cancer risk in a Terry P, Jain M, Miller AB, Howe GR, Rohan TE.Dietary intake of folic acid and colorectal cancer risk in a

cohort of women. Int J Cancer. 2002 Feb 20;97(6):864-7.cohort of women. Int J Cancer. 2002 Feb 20;97(6):864-7.

Regulating HomocysteineRegulating Homocysteine““Having a high homocysteine level means DNA is more vulnerable Having a high homocysteine level means DNA is more vulnerable

to damage, and poorly repaired once damaged. At the other end to damage, and poorly repaired once damaged. At the other end of the scale, a high level of homocysteine has been found to be a of the scale, a high level of homocysteine has been found to be a very good indicator as to whether cancer therapies are working. very good indicator as to whether cancer therapies are working. The homocysteine levels rise when tumours grow and fall when The homocysteine levels rise when tumours grow and fall when they shrink. Forms of cancer already linked to homocysteine they shrink. Forms of cancer already linked to homocysteine include breast, colon and leukaemia among others.include breast, colon and leukaemia among others.

Low homocysteine is likely to reduce your risk of these by a third. Low homocysteine is likely to reduce your risk of these by a third. Coupled by other diet and supplement changes can cut the risk Coupled by other diet and supplement changes can cut the risk by more than 50% .”by more than 50% .”

The H Factor (Book), by Patrick Holford and Dr James Braly. ISBN 0749924195The H Factor (Book), by Patrick Holford and Dr James Braly. ISBN 0749924195

Phytic Acid Prevents CancerPhytic Acid Prevents Cancer

““Phytic acid (myo-inositol hexaphosphoric Phytic acid (myo-inositol hexaphosphoric acid) is present in plants, particularly in acid) is present in plants, particularly in cereals, nuts, oil seed, legumes, pollen, cereals, nuts, oil seed, legumes, pollen, and spores. It has been reported that and spores. It has been reported that phytic acid is chemopreventive in rodent phytic acid is chemopreventive in rodent colon and mammary carcinogenesis colon and mammary carcinogenesis models, in transplanted fibrosarcoma models, in transplanted fibrosarcoma models.”models.”

Midorikawa K, Murata M, Oikawa S, Hiraku Y, Kawanishi S. Protective effect of phytic acid on oxidative DNA Midorikawa K, Murata M, Oikawa S, Hiraku Y, Kawanishi S. Protective effect of phytic acid on oxidative DNA damage with reference to cancer chemoprevention. Biochem Biophys Res Commun. 2001 Nov 2; damage with reference to cancer chemoprevention. Biochem Biophys Res Commun. 2001 Nov 2; 288(3):552-7288(3):552-7

Phytic Acid Prevents Cancer Phytic Acid Prevents Cancer via its Antioxidant Effectsvia its Antioxidant Effects

““This study revealed that phytic acid This study revealed that phytic acid efficiently inhibited oxidative DNA damage. efficiently inhibited oxidative DNA damage. Phytic acid decreased the formation of 8- Phytic acid decreased the formation of 8-oxodG in cultured cells treated with the oxodG in cultured cells treated with the H2O2-generating system using glucose H2O2-generating system using glucose oxidase.”oxidase.”

Midorikawa K, Murata M, Oikawa S, Hiraku Y, Kawanishi S. Protective effect of phytic acid on oxidative DNA Midorikawa K, Murata M, Oikawa S, Hiraku Y, Kawanishi S. Protective effect of phytic acid on oxidative DNA damage with reference to cancer chemoprevention. Biochem Biophys Res Commun. 2001 Nov 2; damage with reference to cancer chemoprevention. Biochem Biophys Res Commun. 2001 Nov 2; 288(3):552-7288(3):552-7

Glutathione Prevents Cancer Glutathione Prevents Cancer via Numerous effectsvia Numerous effects

““Glutathione is an important intracellular Glutathione is an important intracellular antioxidant and redox potential regulator antioxidant and redox potential regulator that plays a vital role in drug detoxification that plays a vital role in drug detoxification and elimination and in cellular protection and elimination and in cellular protection from damage by free radicals, peroxides, from damage by free radicals, peroxides, and toxins.”and toxins.”

Hamilton D, Batist G. Glutathione analogues in cancer treatment. Curr Oncol Rep. 2004 Mar;6(2):116-22.Hamilton D, Batist G. Glutathione analogues in cancer treatment. Curr Oncol Rep. 2004 Mar;6(2):116-22.

Glutathione Prevents Cancer Glutathione Prevents Cancer via Numerous effectsvia Numerous effects

““Molecular alterations reported in many of the Molecular alterations reported in many of the components of the glutathione system in various components of the glutathione system in various tumours and cancer cell lines can lead to tumours and cancer cell lines can lead to increased survival and enhanced chemotherapy increased survival and enhanced chemotherapy drug resistance. Several glutathione analogues drug resistance. Several glutathione analogues that target this system have been developed and that target this system have been developed and used experimentally and clinically in an attempt to used experimentally and clinically in an attempt to improve cancer chemotherapy.”improve cancer chemotherapy.”

Hamilton D, Batist G. Glutathione analogues in cancer treatment. Curr Oncol Rep. 2004 Mar;6(2):116-22.Hamilton D, Batist G. Glutathione analogues in cancer treatment. Curr Oncol Rep. 2004 Mar;6(2):116-22.

Beta-1,3-Glucan: Extraordinary Beta-1,3-Glucan: Extraordinary Immune SupportImmune Support

““70% of rats given a lethal dose of radiation were 70% of rats given a lethal dose of radiation were completely protected from radiation effects when given a completely protected from radiation effects when given a dose of yeast beta glucan by mouth AFTER the dose of yeast beta glucan by mouth AFTER the radiation. Dr. Myra Patchen discovered that beta-glucan radiation. Dr. Myra Patchen discovered that beta-glucan is also a free radical scavenger. It is able to protect blood is also a free radical scavenger. It is able to protect blood macrophages from free radical attack during and after macrophages from free radical attack during and after the radiation allowing these cells to continue to carry the radiation allowing these cells to continue to carry their important functions in the irradiated body and their important functions in the irradiated body and release factors important to the restoration of normal release factors important to the restoration of normal bone marrow production.”bone marrow production.”

Immudyne, Inc.Immudyne, Inc.

Beta-1,3-Glucan: Extraordinary Beta-1,3-Glucan: Extraordinary Immune SupportImmune Support

““When beta-1,3-glucan was added to antibiotic regime in When beta-1,3-glucan was added to antibiotic regime in animals challenged with different bacterial animals challenged with different bacterial (Staphylococcus aureus, Klebsiella pneumoniae, (Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli and others) and viral (Herpes virus) Escherichia coli and others) and viral (Herpes virus) pathogens, a reduced amount of antibiotics or pathogens, a reduced amount of antibiotics or antivirals was needed to cope with the infection. It also antivirals was needed to cope with the infection. It also has an antifungal effect, shown in experiments with has an antifungal effect, shown in experiments with Candida albicans. Such a broad anti-infective Candida albicans. Such a broad anti-infective spectrum of beta-1,3-glucan can be explained only by spectrum of beta-1,3-glucan can be explained only by the fact that the immunostimulation produced by this the fact that the immunostimulation produced by this unique material is non-specific.”unique material is non-specific.”

““Bird ‘Flu and Beta Glucans” article – www.i-c-m.org.ukBird ‘Flu and Beta Glucans” article – www.i-c-m.org.ukImmundyne Inc.Immundyne Inc.

Beta-sitosterol: a new natural compound with Beta-sitosterol: a new natural compound with

chemoprotective/chemopreventive effectschemoprotective/chemopreventive effects..

““This review summarizes the biological activities of This review summarizes the biological activities of presented phytosterols (anti-inflammatory, cholesterol-presented phytosterols (anti-inflammatory, cholesterol-lowering, anti-microbial, anti-bacterial, anti-fungal lowering, anti-microbial, anti-bacterial, anti-fungal effects). Our interest has been focussed especially on effects). Our interest has been focussed especially on their anti-tumor and chemopreventive activity. They have their anti-tumor and chemopreventive activity. They have been shown experimentally to inhibit colon and breast been shown experimentally to inhibit colon and breast cancer development. They act at various stages of tumor cancer development. They act at various stages of tumor development, including inhibition of tumorigenesis, development, including inhibition of tumorigenesis, inhibition of tumor promotion, and induction of cell inhibition of tumor promotion, and induction of cell differentiation. They effectively inhibit invasion of tumor differentiation. They effectively inhibit invasion of tumor cells and metastasis.”cells and metastasis.”

Neoplasma. 2004;51(6):407-14.Taraxasterol and beta-sitosterol: new naturally compounds with Neoplasma. 2004;51(6):407-14.Taraxasterol and beta-sitosterol: new naturally compounds with chemoprotective/chemopreventive effects. Ovesna Z, Vachalkova A, Horvathova Kchemoprotective/chemopreventive effects. Ovesna Z, Vachalkova A, Horvathova K

Spirulina: Cancer Benefits?Spirulina: Cancer Benefits?

““Thus, it has been experimentally Thus, it has been experimentally proven, in vivo and in vitro that it is proven, in vivo and in vitro that it is effective to treat certain allergies, effective to treat certain allergies, anemia, cancer, hepatotoxicity, anemia, cancer, hepatotoxicity, viral and cardiovascular diseases, viral and cardiovascular diseases, hyperglycemia, hyperlipidemia, hyperglycemia, hyperlipidemia, immunodeficiency, and immunodeficiency, and inflammatory processes, among inflammatory processes, among others.”others.”

Chamorro G, Salazar M, Arujo KG, do Santos CP, Ceballos G, Castillo LF. Update on the pharmacology of Chamorro G, Salazar M, Arujo KG, do Santos CP, Ceballos G, Castillo LF. Update on the pharmacology of Spirulina (Arthospira), an unconventional food. Arch Latinoam Nutr. 2002 Sep;52(3):232-40.Spirulina (Arthospira), an unconventional food. Arch Latinoam Nutr. 2002 Sep;52(3):232-40.

Spirulina: Cancer Benefits?Spirulina: Cancer Benefits?

““Several of these activities are attributed to Several of these activities are attributed to Spirulina itself or to some of its components Spirulina itself or to some of its components including fatty acids omega-3 or omega-6, including fatty acids omega-3 or omega-6, beta-carotene, alpha-tocopherol, beta-carotene, alpha-tocopherol, phycocyanin, phenol compounds, and a phycocyanin, phenol compounds, and a recently isolated complex Ca-Spirulan (Ca-recently isolated complex Ca-Spirulan (Ca-SP).”SP).”

Chamorro G, Salazar M, Arujo KG, do Santos CP, Ceballos G, Castillo LF. Update on the pharmacology of Chamorro G, Salazar M, Arujo KG, do Santos CP, Ceballos G, Castillo LF. Update on the pharmacology of Spirulina (Arthospira), an unconventional food. Arch Latinoam Nutr. 2002 Sep;52(3):232-40.Spirulina (Arthospira), an unconventional food. Arch Latinoam Nutr. 2002 Sep;52(3):232-40.

Spirulina: Cancer Benefits? Spirulina: Cancer Benefits? MechanismsMechanisms

““In NK cells, both IFN In NK cells, both IFN gamma and cytolysis gamma and cytolysis are up-regulated by are up-regulated by Spirulina in 50% of Spirulina in 50% of subjects, and IL-18 subjects, and IL-18 levels critically affect levels critically affect the yield of IFN the yield of IFN gamma .”gamma .”

HIrahashi T, Matsumoto M, Hazeki K, Saeki Y, Ui M, Seya T. Activation of the human innate immune system HIrahashi T, Matsumoto M, Hazeki K, Saeki Y, Ui M, Seya T. Activation of the human innate immune system by Spirulina: augmentation of interferon production and NK cytotoxicity by oral administration of hot water by Spirulina: augmentation of interferon production and NK cytotoxicity by oral administration of hot water extract of Spirulina platenis. Int Immunopharmacol. 2002 Mar;2(4):432-34.extract of Spirulina platenis. Int Immunopharmacol. 2002 Mar;2(4):432-34.

A novel glycoprotein obtained from A novel glycoprotein obtained from Chlorella vulgaris strain CK22 shows Chlorella vulgaris strain CK22 shows

antimetastatic immunopotentiation.antimetastatic immunopotentiation.

““A glycoprotein extract (CVS), derived A glycoprotein extract (CVS), derived from the unicellular green alga from the unicellular green alga Chlorella vulgaris, strain CK22, Chlorella vulgaris, strain CK22, exhibited a pronounced anti-tumour exhibited a pronounced anti-tumour effect against both spontaneous and effect against both spontaneous and experimentally induced metastasis experimentally induced metastasis in mice.”in mice.”

Cancer Immunol Immunother. 1998 Feb;45(6):313-20.Cancer Immunol Immunother. 1998 Feb;45(6):313-20.A novel glycoprotein obtained from A novel glycoprotein obtained from Chlorella vulgaris strain CK22 shows antimetastatic immunopotentiation.Chlorella vulgaris strain CK22 shows antimetastatic immunopotentiation.Tanaka K, Yamada A, Noda K, Hasegawa T, Okuda M, Shoyama Y, Nomoto K.Tanaka K, Yamada A, Noda K, Hasegawa T, Okuda M, Shoyama Y, Nomoto K.

Angiogenesis and CartilageAngiogenesis and Cartilage

““Initially, cartilage was considered as a possible Initially, cartilage was considered as a possible natural source of antiangiogenic compounds natural source of antiangiogenic compounds due to its known avascular nature. To date, a due to its known avascular nature. To date, a number of in vitro and in vivo studies have number of in vitro and in vivo studies have suggested the existence of antiangiogenic suggested the existence of antiangiogenic and anti-tumour compounds in bovine and and anti-tumour compounds in bovine and shark cartilage .”shark cartilage .”

Gonzalez RP, Leyva A, Moraes MO. Shark cartilage as source of antiangiogenic compounds: from basic to Gonzalez RP, Leyva A, Moraes MO. Shark cartilage as source of antiangiogenic compounds: from basic to clinical research. Biol Pharm Bull. 2001 Oct;24(10):1097-101.clinical research. Biol Pharm Bull. 2001 Oct;24(10):1097-101.

Bovine Cartilage Reduces Bovine Cartilage Reduces MetastasisMetastasis

““In this study we report that Metastatin, a In this study we report that Metastatin, a cartilage-derived hyaluronan- binding complex cartilage-derived hyaluronan- binding complex consisting of proteolytic fragments of bovine consisting of proteolytic fragments of bovine link protein and aggrecan, is able to block the link protein and aggrecan, is able to block the growth and metastasis of tumour cells .”growth and metastasis of tumour cells .”

Liu N, Lapcevich RK, Underhill CB, Han Z, Gao F, Swartz G, Plum SM, Zhang L, Green SJ. Metastatin: a Liu N, Lapcevich RK, Underhill CB, Han Z, Gao F, Swartz G, Plum SM, Zhang L, Green SJ. Metastatin: a hyaluronan-binding complex from cartilage that inhibits tumour growth. Cancer Res. 2001 Feb hyaluronan-binding complex from cartilage that inhibits tumour growth. Cancer Res. 2001 Feb 1;6(3):1022-8.1;6(3):1022-8.

Shark Liver Oil and CancerShark Liver Oil and Cancer

““Sharks have been claimed to be resistant Sharks have been claimed to be resistant to cancer and oil from their livers have to cancer and oil from their livers have been used in Scandinavian folk been used in Scandinavian folk medicine as an anti-tumour drug. medicine as an anti-tumour drug. Shark liver oil contains 40% or more of Shark liver oil contains 40% or more of squalene. Fish liver oil is also rich in squalene. Fish liver oil is also rich in squalene and polyunsaturated n-3 fatty squalene and polyunsaturated n-3 fatty acids.”acids.”

Skopinska-Rozewskaa E, Chorostowska-Wynimko J, Krotiewski M, Rogala E, Sommer E, Demkow U, Skurak Skopinska-Rozewskaa E, Chorostowska-Wynimko J, Krotiewski M, Rogala E, Sommer E, Demkow U, Skurak H. Inhibitory effect of Greenland shark liver oil combined with squalene and arctic birch ashes on H. Inhibitory effect of Greenland shark liver oil combined with squalene and arctic birch ashes on angiogenesis and L-1 sarcoma growth in Balb/c mic. Pol J Vet Sci. 2003;6(3 Supp.)54-6.angiogenesis and L-1 sarcoma growth in Balb/c mic. Pol J Vet Sci. 2003;6(3 Supp.)54-6.

Rice BranRice Bran

““Rice bran has been shown to Rice bran has been shown to bolster the vitality of the internal bolster the vitality of the internal organs, especially the adrenals, organs, especially the adrenals, thymus, spleen, and thyroid, thymus, spleen, and thyroid, which increase in size and which increase in size and exhibit additional anti-stress exhibit additional anti-stress effects.” effects.”

HEALING WITH WHOLE FOODS, pp. 12-17 Paul Pitchford, North Atlantic BooksHEALING WITH WHOLE FOODS, pp. 12-17 Paul Pitchford, North Atlantic Books

Rice BranRice Bran

““Rice bran contains GPx, an Rice bran contains GPx, an enzyme, anti-oxidant, that enzyme, anti-oxidant, that reduces mucus, boosts reduces mucus, boosts respiratory function, and respiratory function, and helps detoxify the body.” helps detoxify the body.”

HEALING WITH WHOLE FOODS, pp. 12-17 Paul Pitchford, North Atlantic BooksHEALING WITH WHOLE FOODS, pp. 12-17 Paul Pitchford, North Atlantic Books

Quercetin is Anti-carcinogenicQuercetin is Anti-carcinogenic

““Quercetin prevents Quercetin prevents transforming growth factor transforming growth factor alpha (TGF-alpha) and alpha (TGF-alpha) and epidermal growth factor epidermal growth factor (EGF)-induced human PC-(EGF)-induced human PC-3 prostate cancer cell 3 prostate cancer cell proliferation .”proliferation .”

Huynh H et al. Int J Oncol 2003 Sep;(23):821-9Huynh H et al. Int J Oncol 2003 Sep;(23):821-9

Huang YT et al. Br J Pharmacol 1999 Nov;128(5):999-1010Huang YT et al. Br J Pharmacol 1999 Nov;128(5):999-1010

Quercetin is Anti-carcinogenicQuercetin is Anti-carcinogenic

““Quercetin inhibits the synthesis of heat shock Quercetin inhibits the synthesis of heat shock proteins in tumours and blocks the export of proteins in tumours and blocks the export of lactate from tumours creating a lethal level of lactate from tumours creating a lethal level of intracellular acidity. Moreintracellular acidity. More effective against effective against hypoxic tumours and in hyperthermia .”hypoxic tumours and in hyperthermia .”

Kim JH Cancer Res 1984;44(1):102-6Kim JH Cancer Res 1984;44(1):102-6

LysineLysine

““The use of lysine, an amino acid, in The use of lysine, an amino acid, in combination with ascorbic vitamin C will combination with ascorbic vitamin C will lead to a breakthrough in the control of lead to a breakthrough in the control of many forms of cancer and other many forms of cancer and other diseases.” diseases.”

Dr Mathias Rath, NY Speech 2002Dr Mathias Rath, NY Speech 2002

LysineLysine“… “… lysine blocks the enzyme’s ability to lysine blocks the enzyme’s ability to

digest collagen by binding to it. If digest collagen by binding to it. If there is enough lysine to block there is enough lysine to block enzyme molecules the movement of enzyme molecules the movement of cells through the tissue can cells through the tissue can practically stop. I want to emphasize practically stop. I want to emphasize the words “enough lysine”. This is the words “enough lysine”. This is very important, because lysine, like very important, because lysine, like vitamin C, cannot be produced in our vitamin C, cannot be produced in our body. We can only get it from our diet, body. We can only get it from our diet, therefore, deficiency of lysine is likely. therefore, deficiency of lysine is likely. This means that our body’s ability to This means that our body’s ability to control collagen digestion can be control collagen digestion can be compromised if intake of lysine is too compromised if intake of lysine is too low.” low.”

The "Cancer Research Report" was presented by Dr. Aleksandra Niedzwiecki on Sunday, November 28, 2001 The "Cancer Research Report" was presented by Dr. Aleksandra Niedzwiecki on Sunday, November 28, 2001 at the Health Symposium in Berlin at the Health Symposium in Berlin

LysineLysine

““This graph shows that in the This graph shows that in the presence of lysine only 16% of presence of lysine only 16% of cancer cells can move through cancer cells can move through collagen. This inhibitory effect collagen. This inhibitory effect is even more pronounced in is even more pronounced in the presence of additional the presence of additional nutrients such as vitamin C nutrients such as vitamin C and proline. .” and proline. .”

The "Cancer Research Report" was presented by Dr. Aleksandra Niedzwiecki on Sunday, November 28, 2001 The "Cancer Research Report" was presented by Dr. Aleksandra Niedzwiecki on Sunday, November 28, 2001 at the Health Symposium in Berlin at the Health Symposium in Berlin

TaurineTaurine““Previously, we demonstrated in vitro that Previously, we demonstrated in vitro that

taurine significantly attenuated rIL-2-taurine significantly attenuated rIL-2-induced endothelial cell injury, whereas induced endothelial cell injury, whereas the tumor cytotoxicity of lymphokine-the tumor cytotoxicity of lymphokine-activated killer (LAK) cells was enhanced, activated killer (LAK) cells was enhanced, and established that this effect was and established that this effect was Ca^sup 2+^ -dependent. This Ca^sup 2+^ -dependent. This demonstrates the duality of the action of demonstrates the duality of the action of taurine through enhancement of effector taurine through enhancement of effector cell activity against the tumor target while cell activity against the tumor target while protecting the endothelium from the protecting the endothelium from the deleterious effects associated with rIL-2 deleterious effects associated with rIL-2 immunotherapy.”immunotherapy.”

Host defense--A role for the amino acid taurine? JPEN: Journal of Parenteral and Enteral Nutrition, Jan/Feb Host defense--A role for the amino acid taurine? JPEN: Journal of Parenteral and Enteral Nutrition, Jan/Feb 1998 by Stapleton, Philip P, O'Flaherty, Lean, Redmond, H Paul, Bouchier-Hayes, David J1998 by Stapleton, Philip P, O'Flaherty, Lean, Redmond, H Paul, Bouchier-Hayes, David J

TaurineTaurine““Taurine or betaine pretreatment in Taurine or betaine pretreatment in

lipopolysaccharide-injected rats caused lipopolysaccharide-injected rats caused significant decreases in plasma transaminase significant decreases in plasma transaminase activities and hepatic malondialdehyde and DC activities and hepatic malondialdehyde and DC levels, and significant increases in glutathione levels, and significant increases in glutathione and alpha-tocopherol (not betaine) levels without and alpha-tocopherol (not betaine) levels without changing ascorbic acid levels and SOD and changing ascorbic acid levels and SOD and glutathione peroxidase activities in the liver.” glutathione peroxidase activities in the liver.” Taurine is observed to act as an antioxidant of ONOO- to Taurine is observed to act as an antioxidant of ONOO- to decrease lipid peroxidation and thus affect liver plasma membrane decrease lipid peroxidation and thus affect liver plasma membrane Na+, K+-ATPase by restoring its activity.Na+, K+-ATPase by restoring its activity.

Eur J Gastroenterol Hepatol. 2005 Sep;17(9):917-21. The effect of taurine or betaine pretreatment on Eur J Gastroenterol Hepatol. 2005 Sep;17(9):917-21. The effect of taurine or betaine pretreatment on hepatotoxicity and prooxidant status induced by lipopolysaccharide treatment in the liver of rats. Balkan hepatotoxicity and prooxidant status induced by lipopolysaccharide treatment in the liver of rats. Balkan J, Parldar FH, Dogru-Abbasoglu S, Aykac-Toker G, Uysal M.J, Parldar FH, Dogru-Abbasoglu S, Aykac-Toker G, Uysal M.

TaurineTaurine“ “ Taurine is observed to act as an Taurine is observed to act as an

antioxidant of ONOO- to antioxidant of ONOO- to decrease lipid peroxidation and decrease lipid peroxidation and thus affect liver plasma thus affect liver plasma membrane Na+, K+-ATPase by membrane Na+, K+-ATPase by restoring its activity.”restoring its activity.”

World J Gastroenterol. 2005 Jun 21;11(23):3554-7. Peroxynitrite induced decrease in Na+, K+-ATPase activity World J Gastroenterol. 2005 Jun 21;11(23):3554-7. Peroxynitrite induced decrease in Na+, K+-ATPase activity is restored by taurine. Kocak-Toker N, Giris M, Tulubas F, Uysal M, Aykac-Toker G.is restored by taurine. Kocak-Toker N, Giris M, Tulubas F, Uysal M, Aykac-Toker G.

HerpesHerpes ““Among the 10 588 patients hospitalised with Among the 10 588 patients hospitalised with

herpes zoster whom we identified, 1427 herpes zoster whom we identified, 1427 cancers were observed compared with 1239 cancers were observed compared with 1239 expected (relative risk=1.2, 95% confidence expected (relative risk=1.2, 95% confidence interval 1.1-1.2). The risk was substantially interval 1.1-1.2). The risk was substantially elevated during the first year of follow-up, elevated during the first year of follow-up, mainly for haematological cancermainly for haematological cancer.”.”

The risk and prognosis of cancer after hospitalisation for herpes zoster: a population-based follow-up study. The risk and prognosis of cancer after hospitalisation for herpes zoster: a population-based follow-up study. Sorensen HT, Olsen JH, Jepsen P, Johnsen SP, Schonheyder HC, Mellemkjaer Br J Cancer. 2004 Oct Sorensen HT, Olsen JH, Jepsen P, Johnsen SP, Schonheyder HC, Mellemkjaer Br J Cancer. 2004 Oct 4;91(7):1275-9. 4;91(7):1275-9.

TurmericTurmeric

““Turmeric is one of the key Turmeric is one of the key ingredients in many curries, ingredients in many curries, giving them colour and giving them colour and flavour. Curcumin derived flavour. Curcumin derived from Turmeric gives curry its from Turmeric gives curry its yellow colour and having yellow colour and having both strong anti-oxidant and both strong anti-oxidant and anti-inflammatory properties.”anti-inflammatory properties.”

Drug Metab Pharmacokinet. 2004 Aug;19(4):245-63.Cancer prevention by natural compounds.Drug Metab Pharmacokinet. 2004 Aug;19(4):245-63.Cancer prevention by natural compounds.Osuda H, Ohshima Y, Nomoto H, Fujita K, Matsuda E, Iigo M, Takasuka N, Moore MAOsuda H, Ohshima Y, Nomoto H, Fujita K, Matsuda E, Iigo M, Takasuka N, Moore MA

TurmericTurmeric

““Curcumin inhibited chemically Curcumin inhibited chemically induced skin, forestomach, induced skin, forestomach, and colon carcinogenesis in and colon carcinogenesis in post-initiation stage in post-initiation stage in animals .”animals .”

Drug Metab Pharmacokinet. 2004 Aug;19(4):245-63.Cancer prevention by natural compounds.Drug Metab Pharmacokinet. 2004 Aug;19(4):245-63.Cancer prevention by natural compounds.Osuda H, Ohshima Y, Nomoto H, Fujita K, Matsuda E, Iigo M, Takasuka N, Moore MAOsuda H, Ohshima Y, Nomoto H, Fujita K, Matsuda E, Iigo M, Takasuka N, Moore MA

Beetroot Prevents CancerBeetroot Prevents Cancer

““An in vivo anti-tumour promoting An in vivo anti-tumour promoting activity evaluation against the mice activity evaluation against the mice skin and lung bioassays also skin and lung bioassays also revealed a significant tumour revealed a significant tumour inhibitory effect. The combined inhibitory effect. The combined findings suggest that beetroot findings suggest that beetroot ingestion can be one of the useful ingestion can be one of the useful means to prevent cancer.”means to prevent cancer.”

Kapadia GJ, Tokuda H, Konoshima T, Nishino H. Chemoprevention of lung and skin cancer by Beta vulgaris Kapadia GJ, Tokuda H, Konoshima T, Nishino H. Chemoprevention of lung and skin cancer by Beta vulgaris (Beet) root extract. Cancer Lett. 1996 Feb 27;100(1-2):211-4(Beet) root extract. Cancer Lett. 1996 Feb 27;100(1-2):211-4

Vitamin B12 deficiency: a new Vitamin B12 deficiency: a new risk factor for breast cancer? risk factor for breast cancer?

““B12 status may influence breast B12 status may influence breast carcinogenesis and therefore may carcinogenesis and therefore may be a modifiable risk factor for be a modifiable risk factor for breast cancer prevention .”breast cancer prevention .”

Nutr Rev. 1999 Aug;57(8):Vitamin B12 deficiency: a new risk factor for breast cancer? Choi SWNutr Rev. 1999 Aug;57(8):Vitamin B12 deficiency: a new risk factor for breast cancer? Choi SW

Natural Medicines that Prevent Natural Medicines that Prevent Prostate CancerProstate Cancer

““A large amount of data supports the use of A large amount of data supports the use of other agents as potential preventatives, other agents as potential preventatives, including selenium, vitamin E, vitamin D, including selenium, vitamin E, vitamin D, other 5-alpha-reductase inhibitors, other 5-alpha-reductase inhibitors, cycloxygenase-2 inhibitors, lycopene, and cycloxygenase-2 inhibitors, lycopene, and green tea.”green tea.”

Klein EA, Thompson IM. Update on chemoprevention of prostate cancer. Curr Opin Urol. 2004 Klein EA, Thompson IM. Update on chemoprevention of prostate cancer. Curr Opin Urol. 2004 May;14(3):143-9May;14(3):143-9

Vitamin C Prevents Gastric Vitamin C Prevents Gastric CancersCancers

““Experimental gastric tumors seem to Experimental gastric tumors seem to produce more reactive oxygen species produce more reactive oxygen species than non neoplasic gastric tissue. The than non neoplasic gastric tissue. The reduction of oxidative stress and gastric reduction of oxidative stress and gastric tumor incidence in rats were induced by tumor incidence in rats were induced by the intake of ascorbic acid. Therefore, it the intake of ascorbic acid. Therefore, it may have a role in the prevention of may have a role in the prevention of gastric carcinoma . ”gastric carcinoma . ”

Oliveira CP, Kassab P, Lopasso FP, Souza HP, Janiszewski M, Laurindo FR, Iriya K, Laudanna AA. Oliveira CP, Kassab P, Lopasso FP, Souza HP, Janiszewski M, Laurindo FR, Iriya K, Laudanna AA. Protective effect of ascorbic acid in experimental gastric cancer: reduction of oxidative stress.Protective effect of ascorbic acid in experimental gastric cancer: reduction of oxidative stress.World J Gastroenterol. 2003 Mar;9(3):446-8. World J Gastroenterol. 2003 Mar;9(3):446-8.

Vitamin C Prevents Cancer: Vitamin C Prevents Cancer: Mechanisms of ActionMechanisms of Action

““Proposed mechanisms of action for Proposed mechanisms of action for ascorbic acid (ascorbate, vitamin C) in the ascorbic acid (ascorbate, vitamin C) in the prevention and treatment of cancer include prevention and treatment of cancer include (1) enhancement of the immune system, (1) enhancement of the immune system, (2) stimulation of collagen formation (2) stimulation of collagen formation necessary for "walling off" tumors …. ”necessary for "walling off" tumors …. ”

Head KA. Ascorbic acid in the prevention and treatment of cancer. Altern Med Rev. 1998 Jun;3(3):174-86. Head KA. Ascorbic acid in the prevention and treatment of cancer. Altern Med Rev. 1998 Jun;3(3):174-86. Review. Review.


“…“…(3) inhibition of hyaluronidase which (3) inhibition of hyaluronidase which keeps the ground substance around the keeps the ground substance around the tumor intact and prevents metastasis, (4) tumor intact and prevents metastasis, (4) prevention of oncogenic viruses, (5) prevention of oncogenic viruses, (5) correction of an ascorbate deficiency often correction of an ascorbate deficiency often seen in cancer patients, (6) expedition of seen in cancer patients, (6) expedition of wound healing after cancer surgery ... ”wound healing after cancer surgery ... ”



“…“…(7) enhancement of the effect of certain (7) enhancement of the effect of certain chemotherapy drugs, (8) reduction of the chemotherapy drugs, (8) reduction of the toxicity of other chemotherapeutic agents toxicity of other chemotherapeutic agents such as Adriamycin, (9) prevention of free such as Adriamycin, (9) prevention of free radical damage, and (10) neutralization of radical damage, and (10) neutralization of carcinogenic substances. ”carcinogenic substances. ”


Lycopene benefits Lycopene benefits Reproductive Cancers: Potent Reproductive Cancers: Potent

AntidoxidantAntidoxidant““Interest has been heightened in lycopene, Interest has been heightened in lycopene,

in particular, as it has a large number of in particular, as it has a large number of double bonds and thus has been found to double bonds and thus has been found to be the most potent scavenger of oxygen be the most potent scavenger of oxygen free radicals of all the carotenoids.”free radicals of all the carotenoids.”

Barber NJ, Barber J. Lycopene and prostate cancer. Prostate Cancer Prostatic Dis. 2002 Mar;5(1):6-12Barber NJ, Barber J. Lycopene and prostate cancer. Prostate Cancer Prostatic Dis. 2002 Mar;5(1):6-12

Lycopene benefits Prostate Lycopene benefits Prostate Cancer: Reducing IGF-1Cancer: Reducing IGF-1

““In prostate cancer, in particular, a study has In prostate cancer, in particular, a study has demonstrated inhibition of cell line proliferation demonstrated inhibition of cell line proliferation in the presence of physiological concentrations in the presence of physiological concentrations of lycopene in combination with alpha-of lycopene in combination with alpha-tocopherol. Interestingly, a large study has tocopherol. Interestingly, a large study has linked lower levels of IGF-1 (high levels of linked lower levels of IGF-1 (high levels of which are associated with the incidence of which are associated with the incidence of prostate cancer) with increased tomato intake prostate cancer) with increased tomato intake in the diet.”in the diet.”

Barber NJ, Barber J. Lycopene and prostate cancer. Prostate Cancer Prostatic Dis. 2002 Mar;5(1):6-12Barber NJ, Barber J. Lycopene and prostate cancer. Prostate Cancer Prostatic Dis. 2002 Mar;5(1):6-12

Selenium Reduces Most Selenium Reduces Most CancersCancers

““The complete, 13 years, results of the Nutritional The complete, 13 years, results of the Nutritional Prevention of Cancer Trial have been analysed, Prevention of Cancer Trial have been analysed, causing some speculation over the robustness causing some speculation over the robustness of the previously reported findings of reduction of of the previously reported findings of reduction of cancer risks by supplements of selenium (Se) to cancer risks by supplements of selenium (Se) to a cohort of older Americans. These analyses a cohort of older Americans. These analyses confirmed that Se supplementation was confirmed that Se supplementation was associated with marked reductions in risks to associated with marked reductions in risks to total (all-site except skin) carcinomas and to total (all-site except skin) carcinomas and to cancers of the prostate and colon-rectum .”cancers of the prostate and colon-rectum .”

Combs GF Jnr. Status of selenium in prostate cancer prevention. Br J Cancer. 2004 Jul 19;91(2):195-9. Combs GF Jnr. Status of selenium in prostate cancer prevention. Br J Cancer. 2004 Jul 19;91(2):195-9.

ReviewReview

Molecular chemoprevention by Molecular chemoprevention by SeleniumSelenium

““The results …. indicate that selenium, The results …. indicate that selenium, independent of its form and the target independent of its form and the target organ examined, alters several genes in a organ examined, alters several genes in a manner that can account for cancer manner that can account for cancer prevention. Selenium can up regulate prevention. Selenium can up regulate genes related to phase II detoxification genes related to phase II detoxification enzymes, certain selenium-binding enzymes, certain selenium-binding proteins and select apoptotic genes, while proteins and select apoptotic genes, while down regulating those related to phase I down regulating those related to phase I activating enzymes and cell proliferation.” activating enzymes and cell proliferation.”

Mutat Res. 2005 Aug 11; Molecular chemoprevention by selenium: A genomic approach. El-Bayoumy K, Mutat Res. 2005 Aug 11; Molecular chemoprevention by selenium: A genomic approach. El-Bayoumy K, Sinha R.Sinha R.

Carotenoids Induce ApoptosisCarotenoids Induce Apoptosis

““Apoptosis was induced in human MDR1 Apoptosis was induced in human MDR1 transfected mouse lymphoma cells and transfected mouse lymphoma cells and human breast cancer MDA-MB-231 (HTB-human breast cancer MDA-MB-231 (HTB-26) cell lines in the presence of lycopene, 26) cell lines in the presence of lycopene, zeaxanthin and capsanthin.”zeaxanthin and capsanthin.”

Molnar J, Gyemant N, Mucsi I, Molnar A, Szabo M, Kortvelyesi T, Varga A, Molnar P, Toth G. Modulation of Molnar J, Gyemant N, Mucsi I, Molnar A, Szabo M, Kortvelyesi T, Varga A, Molnar P, Toth G. Modulation of multidrug resistance and apoptosis of cancer cells by selected carotenoids. In Vivo. 2004 Mar-multidrug resistance and apoptosis of cancer cells by selected carotenoids. In Vivo. 2004 Mar-Apr:18(2):237-44Apr:18(2):237-44

Garlic Inhibits a Number of Garlic Inhibits a Number of CancersCancers

““Allicin is the major ingredient in crushed Allicin is the major ingredient in crushed garlic and has been shown to inhibit the garlic and has been shown to inhibit the proliferation of human mammary, proliferation of human mammary, endometrial and colon cancer cells.”endometrial and colon cancer cells.”


Garlic Inhibits a Number of Garlic Inhibits a Number of Cancers, in a number of waysCancers, in a number of ways

““Garlic components have been found to Garlic components have been found to block covalent binding of carcinogens to block covalent binding of carcinogens to DNA, enhance degradation of DNA, enhance degradation of carcinogens, have antioxidant and free carcinogens, have antioxidant and free radical scavenging properties and to radical scavenging properties and to regulate cell proliferation, apoptosis and regulate cell proliferation, apoptosis and immune responses.”immune responses.”

Das S. Garlic – A Natural Source of Cancer Preventive Compounds. Asian Pac J Cancer Prev. Das S. Garlic – A Natural Source of Cancer Preventive Compounds. Asian Pac J Cancer Prev. 2002;3(4):305-112002;3(4):305-11

Garlic Regulates the Cell Cycle Garlic Regulates the Cell Cycle and Hormonesand Hormones

““Garlic contains allyl sulphides which in their Garlic contains allyl sulphides which in their volatile state contribute to the strong volatile state contribute to the strong odour. The sulphur compounds inhibit cell odour. The sulphur compounds inhibit cell proliferation of cancer cells, modulate cell proliferation of cancer cells, modulate cell cycle activity and interfere with hormone cycle activity and interfere with hormone action in cancer cells.”action in cancer cells.”


Garlic Induces Apoptosis in Garlic Induces Apoptosis in Cancer CellsCancer Cells

““We found that allicin inhibited the growth of We found that allicin inhibited the growth of cancer cells of murine and human origin. cancer cells of murine and human origin. Allicin induced the formation of apoptotic Allicin induced the formation of apoptotic bodies, nuclear condensation and a typical bodies, nuclear condensation and a typical DNA ladder in cancer cells. Furthermore, DNA ladder in cancer cells. Furthermore, activation of caspases-3, -8 and -9 and activation of caspases-3, -8 and -9 and cleavage of poly (ADP-ribose) polymerase cleavage of poly (ADP-ribose) polymerase were induced by allicin.”were induced by allicin.”

Oommen S, Anto RJ, Srinivas G, Karunagaran D. Allicin (from Garlic) induces caspase-mediated apoptosis in Oommen S, Anto RJ, Srinivas G, Karunagaran D. Allicin (from Garlic) induces caspase-mediated apoptosis in cancer cells. Eur J Pharmacol. 2004 Feb 6;485(1-3):97-103cancer cells. Eur J Pharmacol. 2004 Feb 6;485(1-3):97-103

Flax Seeds Decrease VEGFFlax Seeds Decrease VEGF

““Angiogenesis is important in tumour growth, Angiogenesis is important in tumour growth, progression and metastatic dissemination. progression and metastatic dissemination. Vascular endothelial growth factor (VEGF) is Vascular endothelial growth factor (VEGF) is one key factor in promotion of breast cancer one key factor in promotion of breast cancer angiogenesis. VEGFs are bioactive in the angiogenesis. VEGFs are bioactive in the extracellular space where they become available extracellular space where they become available to the endothelial cells. Phytoestrogens such as to the endothelial cells. Phytoestrogens such as lignans have been shown to alter breast cancer lignans have been shown to alter breast cancer incidence and be cancer-protective in rats.”incidence and be cancer-protective in rats.”

Dabrosin C, Chen J, Wang L, Thompson LU. Flaxseed inhibits metastasis and decreases extra cellular Dabrosin C, Chen J, Wang L, Thompson LU. Flaxseed inhibits metastasis and decreases extra cellular vascular endothelial growth factor in human breast cancer xenografts. Cancer Lett. 2002 Nov vascular endothelial growth factor in human breast cancer xenografts. Cancer Lett. 2002 Nov 8;185(1):31-378;185(1):31-37

Flax Seeds Decrease VEGFFlax Seeds Decrease VEGF

““We show that supplementation of 10% We show that supplementation of 10% flaxseed, the richest source of flaxseed, the richest source of mammalian lignans, to nude mice with mammalian lignans, to nude mice with established human breast tumours established human breast tumours reduced tumour growth and reduced tumour growth and metastasis. Moreover, flaxseed metastasis. Moreover, flaxseed decreased extracellular levels ofdecreased extracellular levels ofVEGF, which may be one VEGF, which may be one mechanistic explanation to the mechanistic explanation to the decreased tumour growth and decreased tumour growth and metastasis.”metastasis.”

Dabrosin C, Chen J, Wang L, Thompson LU. Flaxseed inhibits metastasis and decreases extra cellular Dabrosin C, Chen J, Wang L, Thompson LU. Flaxseed inhibits metastasis and decreases extra cellular vascular endothelial growth factor in human breast cancer xenografts. Cancer Lett. 2002 Nov vascular endothelial growth factor in human breast cancer xenografts. Cancer Lett. 2002 Nov 8;185(1):31-378;185(1):31-37

Grape Seeds (GSP) Prevents Grape Seeds (GSP) Prevents Prostate CancerProstate Cancer

““These data suggest that inhibition of These data suggest that inhibition of metastasis-specific MMPs in tumour cells metastasis-specific MMPs in tumour cells by GSP is associated with the inhibition of by GSP is associated with the inhibition of activation of MAPK and NF kappa B activation of MAPK and NF kappa B pathways, and thus provides the molecular pathways, and thus provides the molecular basis for the development of GSP as a basis for the development of GSP as a novel chemopreventive agent for both novel chemopreventive agent for both androgen-sensitive and –insensitive androgen-sensitive and –insensitive prostate cancer therapies.”prostate cancer therapies.”

Sharma G, Tyagi AK, Singh RP, Chan DC, Agarwal R. Synergistic anti-cancer effects of grape seed extract Sharma G, Tyagi AK, Singh RP, Chan DC, Agarwal R. Synergistic anti-cancer effects of grape seed extract and conventional cytotoxic agent doxurubicin against human breast carcinoma cells. Breast Cancer Res and conventional cytotoxic agent doxurubicin against human breast carcinoma cells. Breast Cancer Res Treat. 2004 May;85(1):1-12Treat. 2004 May;85(1):1-12

Grape Seeds (GSP) TreatsGrape Seeds (GSP) TreatsProstate CancerProstate Cancer

““These findings suggest that GSE These findings suggest that GSE possesses in vivo anticancer efficacy possesses in vivo anticancer efficacy against hormone-refactory human PCA, against hormone-refactory human PCA, which is associated with its which is associated with its antiproliferative, pro-apoptotic and antiproliferative, pro-apoptotic and antiangiogenic activities together with up antiangiogenic activities together with up regulation of IGFBP-3.”regulation of IGFBP-3.”

Singh RP, Tyagi AK, Dhanalakshmi S, Agarwal R, Agarwal C. Grape seed extract inhibits advanced human Singh RP, Tyagi AK, Dhanalakshmi S, Agarwal R, Agarwal C. Grape seed extract inhibits advanced human prostate tumour growth and angiogenesis and upregulates insulin-like growth factor binding protein-3. Int prostate tumour growth and angiogenesis and upregulates insulin-like growth factor binding protein-3. Int J Cancer. 2004 Feb 20;108(5):733-40J Cancer. 2004 Feb 20;108(5):733-40

Grape Seeds (GSE) are Grape Seeds (GSE) are Synergistic with ChemotherapySynergistic with Chemotherapy““Together, these results suggest a strong Together, these results suggest a strong

possibility of synergistic efficacy of GSE possibility of synergistic efficacy of GSE and doxorubicin combination for breast and doxorubicin combination for breast cancer treatment, independent of cancer treatment, independent of oestrogen receptor status of the cancer oestrogen receptor status of the cancer cell.”cell.”

Sharma G, Tyagi AK, Singh RP, Chan DC, Agarwal R. Synergistic anti-cancer effects of grape seed extract Sharma G, Tyagi AK, Singh RP, Chan DC, Agarwal R. Synergistic anti-cancer effects of grape seed extract and conventional cytotoxic agent doxurubicin against human breast carcinoma cells. Breast Cancer Res and conventional cytotoxic agent doxurubicin against human breast carcinoma cells. Breast Cancer Res Treat. 2004 May;85(1):1-12Treat. 2004 May;85(1):1-12

Anthocyanins Prevent Cancer Anthocyanins Prevent Cancer via Numerous Effectsvia Numerous Effects

““Anthocyanin-rich extracts, potent antioxidants Anthocyanin-rich extracts, potent antioxidants and commercially available food colouring and commercially available food colouring agents, have been reported to inhibit the agents, have been reported to inhibit the growth of various cancer cell lines. We growth of various cancer cell lines. We investigated the effect of semi-purified investigated the effect of semi-purified anthocyanin-rich extract from fruits of Aronia anthocyanin-rich extract from fruits of Aronia meloncarpa, on normal colon and colon meloncarpa, on normal colon and colon cancer cell lines.”cancer cell lines.”

Malik M, Zhao C, Schoene N, Guisti MM, Moyer MP, Magnuson BA. Anthocyanin-rich extract from Aronia Malik M, Zhao C, Schoene N, Guisti MM, Moyer MP, Magnuson BA. Anthocyanin-rich extract from Aronia meloncarpa E induces a cell cycle block in colon cancer but not in normal colonic cells. Nutr Cancer. meloncarpa E induces a cell cycle block in colon cancer but not in normal colonic cells. Nutr Cancer. 2003;46(2):186-96.2003;46(2):186-96.

Anthocyanins Prevent Cancer Anthocyanins Prevent Cancer via Numerous Effectsvia Numerous Effects

““The treated cells showed a blockage at G1/G0 The treated cells showed a blockage at G1/G0 and G2/M phases of the cell cycle. The cell and G2/M phases of the cell cycle. The cell cycle arrest coincided with an increased cycle arrest coincided with an increased expression of the p21WAF1 and p27KIP1 expression of the p21WAF1 and p27KIP1 genes and decreased expression of cyclin A genes and decreased expression of cyclin A and B genes. NCM460 normal colon cells and B genes. NCM460 normal colon cells demonstrated <10% growth inhibition at the demonstrated <10% growth inhibition at the highest concentration of 50 mg/ml extract.”highest concentration of 50 mg/ml extract.”

Malik M, Zhao C, Schoene N, Guisti MM, Moyer MP, Magnuson BA. Anthocyanin-rich extract from Aronia Malik M, Zhao C, Schoene N, Guisti MM, Moyer MP, Magnuson BA. Anthocyanin-rich extract from Aronia meloncarpa E induces a cell cycle block in colon cancer but not in normal colonic cells. Nutr Cancer. meloncarpa E induces a cell cycle block in colon cancer but not in normal colonic cells. Nutr Cancer. 2003;46(2):186-96.2003;46(2):186-96.

Fish Oils are Anticarcinogenic Fish Oils are Anticarcinogenic Agents: StudiesAgents: Studies

““Recent intervention studies in breast cancer Recent intervention studies in breast cancer patients indicate that n-3 fatty acids, and patients indicate that n-3 fatty acids, and docosahexaenoic acid (DHA) in particular, docosahexaenoic acid (DHA) in particular, increase the response to chemo-preventive increase the response to chemo-preventive agents. In patients with colorectal cancer, agents. In patients with colorectal cancer, eicosapentaenoic acid (EPA) and DHA eicosapentaenoic acid (EPA) and DHA decrease cell proliferation, and modulate decrease cell proliferation, and modulate favourably the balance between colonic cell favourably the balance between colonic cell proliferation and apoptosis.”proliferation and apoptosis.”

Simopoulos AP. The traditional diet of Greece and cancer. Eur J Cancer Prev. 2004 Jun;13(3)219-230Simopoulos AP. The traditional diet of Greece and cancer. Eur J Cancer Prev. 2004 Jun;13(3)219-230

Fish Oils are Anticarcinogenic Fish Oils are Anticarcinogenic Agents: MechanismsAgents: Mechanisms

““Many mechanisms are involved, including Many mechanisms are involved, including suppression of neoplastic transformation, suppression of neoplastic transformation, cell growth inhibition, and enhanced cell growth inhibition, and enhanced apoptosis and anti-angiogenicity, through apoptosis and anti-angiogenicity, through the inhibition of eicosanoid production the inhibition of eicosanoid production from n-6 fatty acids; and suppression of from n-6 fatty acids; and suppression of cyclooxygenase 2 (COX-2), interleukin 1 cyclooxygenase 2 (COX-2), interleukin 1 (IL1) and IL-6 gene expression by n-3 fatty (IL1) and IL-6 gene expression by n-3 fatty acids.”acids.”

Simopoulos AP. The traditional diet of Greece and cancer. Eur J Cancer Prev. 2004 Jun;13(3)219-230Simopoulos AP. The traditional diet of Greece and cancer. Eur J Cancer Prev. 2004 Jun;13(3)219-230

Olive Oil Protects Against Olive Oil Protects Against CancerCancer

““Cumulative evidence suggests that olive oil Cumulative evidence suggests that olive oil may have a role in the prevention of may have a role in the prevention of coronary disease and several types of coronary disease and several types of cancer because of its high levels of cancer because of its high levels of monounsaturated fatty acids and monounsaturated fatty acids and polyphenolic compounds.”polyphenolic compounds.”

Hu FB. The Mediterranean diet and mortality – olive oil and beyond. N Engl J Med. 2003 Jun Hu FB. The Mediterranean diet and mortality – olive oil and beyond. N Engl J Med. 2003 Jun 26;348(26):2595-626;348(26):2595-6

Olive Oil and Fish Oil Protects Olive Oil and Fish Oil Protects Against Bowel CancerAgainst Bowel Cancer

““Supplementation with fish oil or olive oil Supplementation with fish oil or olive oil results in an induction of apoptosis and results in an induction of apoptosis and cell differentiation. The latest effect was cell differentiation. The latest effect was also induced by oleic and linoleic acid. also induced by oleic and linoleic acid. Fish oil diminishes significantly cell Fish oil diminishes significantly cell proliferation. Supplementation with fish oil proliferation. Supplementation with fish oil and olive oill results in an early and olive oill results in an early downregulation of COX-2 followed by a downregulation of COX-2 followed by a decrease in Bcl-2 expression.”decrease in Bcl-2 expression.”

Lior X, Pons E, Roca A, Alvarez M, Mane J, Fernandex-Banares F, Gassull MA. The effects of fish oil, olive Lior X, Pons E, Roca A, Alvarez M, Mane J, Fernandex-Banares F, Gassull MA. The effects of fish oil, olive oil, oleic acid and linoeic acid on colorectal neoplastic processes. Clin Nutr. 2003 Feb; 22(1_:71-9oil, oleic acid and linoeic acid on colorectal neoplastic processes. Clin Nutr. 2003 Feb; 22(1_:71-9

Olive Oil Protects Against Olive Oil Protects Against Breast Cancer in OffspringBreast Cancer in Offspring

““These results indicate that perinatal These results indicate that perinatal exposure to Olive oil may have a exposure to Olive oil may have a protective effect against future protective effect against future development of mammary cancer in development of mammary cancer in female offspring, whereas high-fat diets female offspring, whereas high-fat diets fed to pregnant and lactating rats, in fed to pregnant and lactating rats, in particular corn oil, may be deleterious.”particular corn oil, may be deleterious.”

Stark AH, Kossoy G, Zusman I, Yarden G, Madar Z. Olive oil consumption during pregnancy and lactation in Stark AH, Kossoy G, Zusman I, Yarden G, Madar Z. Olive oil consumption during pregnancy and lactation in rats influences mammary cancer development in female offspring. Nutr Cancer. 2003;46(1):59-65rats influences mammary cancer development in female offspring. Nutr Cancer. 2003;46(1):59-65

Olive Oil: Bottom LineOlive Oil: Bottom Line

““High consumption of extra-virgin olive oils, High consumption of extra-virgin olive oils, which are particularly rich in phenolic which are particularly rich in phenolic antioxidants, ie hydroxytyrosol, tyrosol, antioxidants, ie hydroxytyrosol, tyrosol, oleuropein, lignans, as well as squalene oleuropein, lignans, as well as squalene and oleic acid, should afford considerable and oleic acid, should afford considerable protection against cancer (colon, breast, protection against cancer (colon, breast, skin), coronary heart disease and ageing skin), coronary heart disease and ageing by inhibiting oxidative stress.”by inhibiting oxidative stress.”

Filik L, Ozyilkan O. Olive oil consumption and cancer risk. Eur J Clin Nutr. 2003 Jan;57(1):191Filik L, Ozyilkan O. Olive oil consumption and cancer risk. Eur J Clin Nutr. 2003 Jan;57(1):191

Mediterranean Diets Protect Mediterranean Diets Protect Against Lung CancerAgainst Lung Cancer

““After careful control for several smoking After careful control for several smoking variables, we found a protective effect for variables, we found a protective effect for high consumption of carrots (odds ratio high consumption of carrots (odds ratio [OR] = 0.67), tomatoes (OR = 0.59), white [OR] = 0.67), tomatoes (OR = 0.59), white meat (OR = 0.66), exclusive use of olive meat (OR = 0.66), exclusive use of olive oil (OR = 0.67), and regular consumption oil (OR = 0.67), and regular consumption of sage (OR = 0.43).”of sage (OR = 0.43).”

Fortes C, Forastiere F, Farchi S, Mallone S, Trequattrinni T, Anatra F, Schmid G, Perucci CA. The protective Fortes C, Forastiere F, Farchi S, Mallone S, Trequattrinni T, Anatra F, Schmid G, Perucci CA. The protective effect of the Mediterranean diet on lung cancer. Nutr Cancer. 2003;46(1):30-7.effect of the Mediterranean diet on lung cancer. Nutr Cancer. 2003;46(1):30-7.

Avocado Contains Persenone Avocado Contains Persenone A, an Anticancer ComponentA, an Anticancer Component

““This study thus suggests that persenone A This study thus suggests that persenone A is a possible agent to prevent is a possible agent to prevent inflammation-associated diseases inflammation-associated diseases including cancer .”including cancer .”

Kim OK, Murakami A, Takahashi D, Nakamura Y, Torikai K, Kim HW, Ohigashi H. An avocado constituent, Kim OK, Murakami A, Takahashi D, Nakamura Y, Torikai K, Kim HW, Ohigashi H. An avocado constituent, persenone A, suppresses expression of inducible forms of nitric oxide synthase and cyclooxygenase in persenone A, suppresses expression of inducible forms of nitric oxide synthase and cyclooxygenase in macrophages, and hydrogen peroxide generation in mouse skin.macrophages, and hydrogen peroxide generation in mouse skin.Biosci Biotechnol Biochem. 2000 Nov;64(11):2504-7.Biosci Biotechnol Biochem. 2000 Nov;64(11):2504-7.

Berries (Anthocyanins) Reduce Berries (Anthocyanins) Reduce Cancer RiskCancer Risk

““Principal therapeutic benefits attributable to Principal therapeutic benefits attributable to anthocyanins include antioxidant anthocyanins include antioxidant protection and maintenance of DNA protection and maintenance of DNA integrity. Anthocyanins also serve as anti-integrity. Anthocyanins also serve as anti-inflammatory and anti-mutagenic agents inflammatory and anti-mutagenic agents and provide cardioprotection by and provide cardioprotection by maintaining vascular permeability .”maintaining vascular permeability .”

Bagchi D, Sen CK, Bagchi M, Atalay M.Bagchi D, Sen CK, Bagchi M, Atalay M. Anti-angiogenic, antioxidant, and anti-carcinogenic properties of a Anti-angiogenic, antioxidant, and anti-carcinogenic properties of a novel anthocyanin-rich berry extract formula. Biochemistry (Mosc). 2004 Jan;69(1):75-80novel anthocyanin-rich berry extract formula. Biochemistry (Mosc). 2004 Jan;69(1):75-80

Berries (Anthocyanins) Reduce Berries (Anthocyanins) Reduce Cancer RiskCancer Risk

““Free radicals oxidatively damage lipids and Free radicals oxidatively damage lipids and proteins and compromise genomic DNA proteins and compromise genomic DNA integrity. They are widely recognized as the integrity. They are widely recognized as the root cause of numerous degenerative diseases root cause of numerous degenerative diseases including cancer. Antioxidants function as including cancer. Antioxidants function as inhibitors at both initiation and inhibitors at both initiation and promotion/propagation/transformation stages promotion/propagation/transformation stages of tumor promotion/carcinogenesis, and of tumor promotion/carcinogenesis, and protect cells against oxidative damage.”protect cells against oxidative damage.”

Bagchi D, Sen CK, Bagchi M, Atalay. Anti-angiogenic, antioxidant, and anti-carcinogenic properties of a novel Bagchi D, Sen CK, Bagchi M, Atalay. Anti-angiogenic, antioxidant, and anti-carcinogenic properties of a novel anthocyanin-rich berry extract formula. Biochemistry (Mosc). 2004 Jan;69(1):75-80anthocyanin-rich berry extract formula. Biochemistry (Mosc). 2004 Jan;69(1):75-80

Bagchi D, Sen CK, Bagchi M, Atalay M.Anti-angiogenic, antioxidant, and anti-carcinogenic properties of a Bagchi D, Sen CK, Bagchi M, Atalay M.Anti-angiogenic, antioxidant, and anti-carcinogenic properties of a novel anthocyanin-rich berry extract formula.novel anthocyanin-rich berry extract formula.Biochemistry (Mosc). 2004 Jan;69(1):75-80Biochemistry (Mosc). 2004 Jan;69(1):75-80

Inhibition of VEGF by Berries Inhibition of VEGF by Berries

Vitamin E Reduces Cancer Vitamin E Reduces Cancer Growth and ProliferationGrowth and Proliferation

““Human evidence indicates an inverse Human evidence indicates an inverse relationship between vitamin E levels and relationship between vitamin E levels and tumour incidence. Binding proteins for tumour incidence. Binding proteins for vitamin E exist in plasma as well as in vitamin E exist in plasma as well as in cells and have been identified in tumour cells and have been identified in tumour cells as well. Tocotrienols have a negative cells as well. Tocotrienols have a negative effect on growth and proliferation of some effect on growth and proliferation of some types of human cancer cells.”types of human cancer cells.”

Drisko JA, Chapman J, Hunter VJ. The use of antioxidant therapies during chemotherapy. Gynecol Oncol. Drisko JA, Chapman J, Hunter VJ. The use of antioxidant therapies during chemotherapy. Gynecol Oncol. 2003 Mar;88(3):434-9. Review. 2003 Mar;88(3):434-9. Review.

Green Tea: Anticancer DrinkGreen Tea: Anticancer Drink

““Tea is one of the most popular beverages in the Tea is one of the most popular beverages in the world and the consumption of tea has been world and the consumption of tea has been associated with a decreased risk of developing associated with a decreased risk of developing cancer of the ovary, oral cavity, colon, cancer of the ovary, oral cavity, colon, stomach, and prostate. This beneficial health stomach, and prostate. This beneficial health effect has been attributed to the catechins in effect has been attributed to the catechins in tea: (-)-epicatechin (EC), (-)-epigallocatechin tea: (-)-epicatechin (EC), (-)-epigallocatechin (EGC), (-)-epicatechin gallate (ECG) and (-)-(EGC), (-)-epicatechin gallate (ECG) and (-)-epigallocatechin gallate (EGCG).”epigallocatechin gallate (EGCG).”

Heber D. Vegetables, fruits and phytoestrogens in the prevention of diseases. J Postgrad Med. 2004 Apr-Heber D. Vegetables, fruits and phytoestrogens in the prevention of diseases. J Postgrad Med. 2004 Apr-Jun;50(2):145-9.Jun;50(2):145-9.

Green Tea Inhibits Cancer Green Tea Inhibits Cancer GrowthGrowth

““In recent years, epigallocatechin-3-gallate In recent years, epigallocatechin-3-gallate (EGCG), the major polyphenolic (EGCG), the major polyphenolic constituent present in green tea, has constituent present in green tea, has shown remarkable effects in inhibiting shown remarkable effects in inhibiting cancer cell growth both in cell cancer cell growth both in cell

culture system and in in vivo culture system and in in vivo

tumour models .”tumour models .”

Gupta S, Hussain T, Mukhtar H. Molecular pathway for (-)-epigallocatechin-3-gallate-induced cell cycle arrest Gupta S, Hussain T, Mukhtar H. Molecular pathway for (-)-epigallocatechin-3-gallate-induced cell cycle arrest and apoptosis of human prostate carcinoma cells. Arch Biochem Biophys. 2003 Feb 1;410(1):177-85. and apoptosis of human prostate carcinoma cells. Arch Biochem Biophys. 2003 Feb 1;410(1):177-85.

Green Tea Upregulates p21, an Green Tea Upregulates p21, an anti cancer geneanti cancer gene

““Earlier studies in our laboratory have shown Earlier studies in our laboratory have shown that treatment of androgen-sensitive and that treatment of androgen-sensitive and androgen-insensitive human prostrate androgen-insensitive human prostrate carcinoma cells with EGCG resulted in carcinoma cells with EGCG resulted in G0/G1 phase cell cycle arrest and G0/G1 phase cell cycle arrest and apoptosis, irrespective of the p53 status of apoptosis, irrespective of the p53 status of these cells. This effect was mediated by these cells. This effect was mediated by upregulation in the protein expression of upregulation in the protein expression of WAF1/P21 .”WAF1/P21 .”


Green Tea Normalises the Green Tea Normalises the Cyclins that Drive Cancer CellsCyclins that Drive Cancer Cells““In the present study, we demonstrate that In the present study, we demonstrate that

EGCG, via modulation in the cki-cyclin-cdk EGCG, via modulation in the cki-cyclin-cdk machinery, results in a G1 phase arrest of machinery, results in a G1 phase arrest of the cell cycle followed by apoptosis of the cell cycle followed by apoptosis of human prostate carcinoma cells .”human prostate carcinoma cells .”


Fulvic AcidFulvic Acid

““Patients with cancer causing tumors of the Patients with cancer causing tumors of the esophagus had 100% success rate in esophagus had 100% success rate in preventing tumor progression into the preventing tumor progression into the cancerous state when treated for two cancerous state when treated for two years with a humic extract solution.” years with a humic extract solution.”

Yuan, Shenyuan; Fulvic Acid, 4 1988; in Application of Fulvic acid and its derivatives in the fields of agriculture Yuan, Shenyuan; Fulvic Acid, 4 1988; in Application of Fulvic acid and its derivatives in the fields of agriculture and medicine; First Edition: June 1993and medicine; First Edition: June 1993

Fulvic AcidFulvic Acid

““Outpatient medical hospital studies on thyroid Outpatient medical hospital studies on thyroid tumors, some cancerous, showed that tumors, some cancerous, showed that injections with a special humic extract was injections with a special humic extract was 90% successful in stopping tumor growth 90% successful in stopping tumor growth and diminishing size of tumors, with 80% of and diminishing size of tumors, with 80% of patients having complete cures.”patients having complete cures.”

For more information on Fulvic Acid please For more information on Fulvic Acid please visit www.info-archive.comvisit www.info-archive.com

He, Shenyi, et al; Humic acid in Jiangxi Province, 1 (1982)He, Shenyi, et al; Humic acid in Jiangxi Province, 1 (1982)

Buffered Vitamin C FlushBuffered Vitamin C Flush

Involves the consumption Involves the consumption of very high doses of of very high doses of buffered Vitamin C for a 1-2 buffered Vitamin C for a 1-2 day period to magnify day period to magnify detoxification and detoxification and strengthen the Immune strengthen the Immune system.system.

The Vitamin C must contain The Vitamin C must contain a good percentage of a good percentage of bioflavonoids and must be bioflavonoids and must be buffered with a spectrum of buffered with a spectrum of buffering minerals.buffering minerals.

Instructions:1. Add 1tsp (2000mgs) of

Vitamin C to a glass of water and repeat every 1/2 hr until diarrhea results.

2. Subtract 1 tsp from total of tsps needed to produce diarrhea and add this amount to a drink every 4 hrs for 1-2 days.

3. Decrease dosage if stool becomes watery.

Nutri-Tech Solutions Pty Ltd “Nutrition Matters” 2005, Qld, Australia.

BioActiv BioActiv Buffered Vitamin C with Buffered Vitamin C with Hesperidin and MineralsHesperidin and Minerals

The World's most popular nutrient! The World's most popular nutrient! Vitamin C is even better in this formula! Vitamin C is even better in this formula!

Hesperidin is derived from the pith of Hesperidin is derived from the pith of unripened lemons. unripened lemons.

Try this great tasting, economical, Try this great tasting, economical, refreshing, revitalising, immune refreshing, revitalising, immune boosting formula. boosting formula.

BioActiv Buffered Vitamin C Powder is BioActiv Buffered Vitamin C Powder is the best tasting product in its class. the best tasting product in its class.

This formula has less overall sugars This formula has less overall sugars than its main rival, fits into the budget than its main rival, fits into the budget price bracket, has extra minerals to add price bracket, has extra minerals to add further value and health benefits and is further value and health benefits and is a practitioner exclusive product that is a practitioner exclusive product that is useful for the whole family. useful for the whole family.

Ingredients: Each 2 gram contains: Ascorbic Acid 800mg, Calcium Ascorbate 200mg, Hesperidin 190mg, Calcium Phosphate 100mg, Magnesium Phosphate 190mg, Zinc Sulphate Monohydrate 2.9mg and balanced exipients: Fructose, Glucose, Silica, Steviosides, with a tangy natural lemon flavour.

BioActiv Super B LiquidVital Links for optimal cellular energy. Developed to assist rapid absorption. First high potency B complex liquid, high in additional co factors (choline & inositol). FREE from sorbitol, yeast and artificial colours. Pure B Vitamins in a purified water solution..

Each 5ml dose contains: Thiamine HCl (B1) 30mg, Riboflavine (B2) 5mg, Nicotinamide (B3), 50mg, Dexpanthenol (provitamin B5) 50mg, Pyridoxine HCl (B6), 30mg, Folic Acid 215mcg, Cyancobalamin (B12) 215mcg, Biotin 30mcg, Inositol 125mcg, Choline Bitartrate 250mg.The Practitioner may supervise the patient towards a higher dose when energy is needed in the treatemnt of chronic conditions.Serving Suggestion: Take 5ml 2 times daily with meals (10ml/day = 50 days) or as prescribed.

Ingredients:Whey powder (from Milk), whey proteinconcentrate (from Milk), dextrose (from tapioca), inulin, mineral salts (calcium carbonate), natural vanilla, emulsifier (tartaric acid), minerals(magnesium oxide, zinc sulphate, ferrous gluconate, potassium iodide),stabliser ( potassium phosphate), vegetable gums (xanthan gum, guar gum), antioxidant (a-tocepherol), vitamins (C,E,niacin, riboflavin, B6 thiamine, A, folate,D, B12).

Nu-Whey is a super nutritious low allergy whey powder. It is the first whey milk substitute to be free of casein, gluten, corn, soy and wheat. Mixes in an instant. 100 grams make a litre of the delicious milk alternative that when mixed will keep in the fridge for 4-5 days. Suitable for children, adults and great for sportspeople.

Highly suited to those with difficulties with certain food absorption, allergies and who are convalescing . Please do not confuse with regular whey powder, this magnificent product is very different in nutrition, taste and is reasonably instantly mixed. Use as a substitute in all recipes that call for cows milk. We tested the several brands of whey milk drinks on the market and found they all contained casein. One major brand did not have this disclosed in their ingredients list. This is not the ethical “whey” to go.

Nu-Whey helps release energy slowly to help vitality and sustain appetite. Whey proteins are easy to digest into branch chain amino acids which aid muscle repair and growth. Nu-Whey is a probiotic to assist the good bacteria (from fermented foods in the diet) to flourish and maintain gastro-intestinal hygiene.

DOES MILK MAKE YOUR PATIENTS

SICK?

GlutenGluten intolerance intolerance A major cause of gastrointestinal inflammation A major cause of gastrointestinal inflammation

and may be a precursor to inflammation in the and may be a precursor to inflammation in the large bowel, including polypslarge bowel, including polyps..

BrighterLife products are free of many allergy triggering ingredients. We have chosen easy to digest flours, i.e. Rice Flour, Potato Starch and Tapioca Starch. A small amount of raw sugar is used in some of our products to improve palatability. This raw sugar can be sifted out if required. We use a unique whey formula which has pre-digested qualities. All maltodextrins and dextrose are sourced from Tapioca. This product has also been endorsed by the Australian Coeliac Society as Gluten Free.

BioActiv BioActiv G.N.BG.N.B (GLYCO NUTRITIONAL(GLYCO NUTRITIONAL BLEND)BLEND)

G.N.B. has a pleasant taste that most people G.N.B. has a pleasant taste that most people enjoy in water, fruit or vegetable juice. The enjoy in water, fruit or vegetable juice. The ingredients are an excellent synergy and may ingredients are an excellent synergy and may assist with absorption and utilisation of other assist with absorption and utilisation of other natural remedies. natural remedies.

G.N.B. was designed as a highly concentrated G.N.B. was designed as a highly concentrated food to give the body nutritional support to food to give the body nutritional support to assist the self-healing processes. assist the self-healing processes.

G.N.B. was the first super green product in G.N.B. was the first super green product in Australia to incorporate the methylating Australia to incorporate the methylating benefits of MSM and Dimethyl-Glycine. benefits of MSM and Dimethyl-Glycine.

It is best used as an adjunct to diet, herbal and It is best used as an adjunct to diet, herbal and homeopathic remedies. Packed with highly homeopathic remedies. Packed with highly Nutritious Food Factors & Concentrates Nutritious Food Factors & Concentrates known for fortifying body systems. known for fortifying body systems.

May assist a variety of burned out May assist a variety of burned out syndromes that predispose one to a loss syndromes that predispose one to a loss of energy and of energy and poor intestinal motility.poor intestinal motility.

•Ingredients: Green Barley, Whey Protein Concentrate (WPC80), Whey Protein Isolate (WPI90), Lecithin, Rice Bran, Bee Pollen, Beetroot, DMG (Di Methyl Glycine), Licorice Root, Psyllium Husk, Slippery Elm, Hesperidin, L-Glutamine, Yucca Powder, MSM (Methyl Sulphonyl Methane), Carob Powder, Guar Gum, Organic Lactic Ferments (Hawaiian Spirulina, Dunaliella Salina, Chlorella, Barley Grass, Wheat Grass, Alfalfa Grass, Oat Grass, Kelp, New Guinea Yam), Natural Vanilla, Chrysanthemum Powder, BioActivated Silica Dioxide.

Bio-Activ Beta.Pro 300bBio-Activ Beta.Pro 300b

Ingredients: Green Barley Pwdr, Rice Bran, Whey Protein Conc. Bee Pollen, Lecithin, Beta-Sitosterol, Soy Protein Isolate, Oligofructose, Siberian Ginseng, Glucosamine, Inositiol Hexaphosphate, DMG, MSM, Tumeric, Horsetail, Tienchi Ginseng, Liquorice Root, Bovine Tracheal Cartilage, L-Taurine, Calcium Carbonate, Sarsaparilla, L-Glutamine, Magnesium Citrate, Quercetin, Vegetable Derived Multistrain Lactobacilli, Natural Lemon Flavour, Cinnamon, Chrysanthemum Leaf Pwdr. Zinc Oxide, Selenium Yeast, Potassium Iodide

Natural Power Foods plus Plant Sterol Concentrates that are natural sources of Anti0xidants and energy Metabolites.

These factors help regulate biochemical pathways.

Assist with gut hygiene and mucosa support

Excellent support for liver function, bile production and detoxification.

OXYGENOXYGEN

Vital for Life Vital for Life Biocatalyst Biocatalyst Oxygen Starvation caused by:-Oxygen Starvation caused by:-

Toxic StressToxic Stress Emotional StressEmotional Stress Physical trauma and infectionsPhysical trauma and infections Reduction in available atmospheric oxygenReduction in available atmospheric oxygen Increase in Carbon MonoxideIncrease in Carbon Monoxide Improper FoodImproper Food Lack of ExerciseLack of Exercise SmokingSmoking High intake of alcoholHigh intake of alcohol PollutionPollution

Oxygen

Why Di-Oxymed?Why Di-Oxymed?

Di-Oxymed is manufactured using non-chemical Di-Oxymed is manufactured using non-chemical formulation with no mixing of potentially toxic formulation with no mixing of potentially toxic chemicals.chemicals.

One of the highest concentrations of One of the highest concentrations of bioavailable stabilized oxygen available today.bioavailable stabilized oxygen available today.

Colourless, non-toxic, hypoallergenic and Colourless, non-toxic, hypoallergenic and completely safe to use with no known toxicity for completely safe to use with no known toxicity for man of animals.man of animals.

Low salt – less than 20ppmLow salt – less than 20ppm Balanced to the pH of the bloodstream, Balanced to the pH of the bloodstream,

Diatomic Oxygen Diatomic Oxygen

OxygenOxygen is the most vital element is the most vital element to the human body. 90% of our to the human body. 90% of our body's life energy is created by body's life energy is created by oxygen. Insufficient oxygen means oxygen. Insufficient oxygen means insufficient biological resources insufficient biological resources which can result in ailments ranging which can result in ailments ranging from mild fatigue to life threatening from mild fatigue to life threatening diseases. Di-Oxymed, provides a diseases. Di-Oxymed, provides a highly effective solution to one of highly effective solution to one of our most perplexing problems: How our most perplexing problems: How to feed our bodies more oxygen thus to feed our bodies more oxygen thus allowing our bodies to more allowing our bodies to more effectively oxidize and metabolize effectively oxidize and metabolize life and health giving nutrientslife and health giving nutrients..

Practitioner Only

BioResearch Homoeopathic BioResearch Homoeopathic ComplexesComplexes

Why BioResearch?Why BioResearch?

The FormulaeThe Formulae

Low Ethanol Low Ethanol SublingualSublingual Ingredients act synergistically togetherIngredients act synergistically together Multiple potenciesMultiple potencies Provings unlikelyProvings unlikely Safe for PregnancySafe for Pregnancy Safe for InfantsSafe for Infants Safe for the ElderlySafe for the Elderly Ease of ComplianceEase of Compliance Pleasant TastePleasant Taste Children Easy to DoseChildren Easy to Dose The Formulae can be used as Part of a Treatment Regime The Formulae can be used as Part of a Treatment Regime Inexpensive Start-up CostsInexpensive Start-up Costs Up to 5 year use by date Up to 5 year use by date

The ProtocolsThe Protocols

BioResearch Protocols - the best BioResearch Protocols - the best combinations of BioResearch Formulae combinations of BioResearch Formulae for temporary relief of symptoms for for temporary relief of symptoms for specific disorders specific disorders

Treatment protocols are simple with Treatment protocols are simple with great results great results

BioResearch Protocol No 1BioResearch Protocol No 1 – – Parasitic InfectionParasitic Infection

[May assist with the temporary relief of symptoms of][May assist with the temporary relief of symptoms of]

AdultAdult Formula WRMFormula WRM, , 10 drops 3 times daily ½ 10 drops 3 times daily ½

hour before mealshour before meals Formula VSLFormula VSL, 3-6 drops 3 times daily ½ , 3-6 drops 3 times daily ½

hour after mealshour after meals 30 day programme30 day programme

BioResearch Protocol No 2BioResearch Protocol No 2 – – Parasitic Infection with constipationParasitic Infection with constipation [May assist with the temporary [May assist with the temporary

relief of symptoms of]relief of symptoms of]

Adult DoseAdult Dose Formula WRMFormula WRM, , 10 drops 3 times daily ½ 10 drops 3 times daily ½

hour before mealshour before meals Formula GTFormula GT, 3-6 drops 3 times daily ½ , 3-6 drops 3 times daily ½

hour after mealshour after meals

Prescribe until the constipation is relieved Prescribe until the constipation is relieved then transfer to Protocol No 1 for the then transfer to Protocol No 1 for the remainder of the 30 day programmeremainder of the 30 day programme

Some clients may require more than a 30 Some clients may require more than a 30 day programme of BioResearch Protocol day programme of BioResearch Protocol No 1 or Protocol No 2. Depending on the No 1 or Protocol No 2. Depending on the presenting symptoms you may need to presenting symptoms you may need to repeat for another 30 day programme.repeat for another 30 day programme.

Formula 12

INGREDIENTS: (Potency 6C, 12C, 15C)• Calc. fluor. Tissue Strengthener CANCER

• Calc. phos. Cell Builder CAPRICORN

• Calc. sulf. Suppuration Remover SCORPIO

• Ferrum phos. Inflammation Remover PISCES

• Kali. mur. Congestion Remover GEMINI

• Kali. phos. Nerve Power Activate ARIES

• Kali. sulf. Cell Oxygenator VIRGO

• Mag. phos. Neuromuscular Co-Ordinator LEO

• Nat. mur. Fluid BalancerAQUARIUS

• Nat. phos. Metabolic Acid Remover LIBRA

• Nat. sulf. Problem Fluid Remover TAURUS

• Silicea Calcium Organizer SAGITTURUS

BioResearch Protocol 61 – BioResearch Protocol 61 – General TonicGeneral Tonic

Formula 12Formula 12, 10, 10 drops, once daily on rising drops, once daily on rising Formula GTFormula GT, 3-6 drops , 4 times daily ½ , 3-6 drops , 4 times daily ½

hour after meals and at bedtime hour after meals and at bedtime

or in 600ml of water with 5 ml of or in 600ml of water with 5 ml of

BioActiv Di-OxymedBioActiv Di-Oxymed

The EndThe EndPresented by Glen Gillard Presented by Glen Gillard

DIP N.T (GOV ACCRED) C.E.C.H Ird. M.C.M.ADIP N.T (GOV ACCRED) C.E.C.H Ird. M.C.M.A

whole foods and nutrition

Health & Medicine

dayold broccoli sprouts

broccoli act

broccoli causes g1 cell

glucosinolate of sulforaphane

sulforaphane sfn

sulforaphane induced

detoxification enzymes

leukemic cell growth