what must i do about abnormal lft? kevin rosenfeld consultant radiologist west hertfordshire...

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What must I do about abnormal LFT? KEVIN ROSENFELD Consultant Radiologist West Hertfordshire Hospitals Spire Hospital Harpenden Spire Hospital Bushey

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Page 1: What must I do about abnormal LFT? KEVIN ROSENFELD Consultant Radiologist West Hertfordshire Hospitals Spire Hospital Harpenden Spire Hospital Bushey

What must I do about abnormal LFT?KEVIN ROSENFELD

Consultant Radiologist

West Hertfordshire Hospitals

Spire Hospital Harpenden

Spire Hospital Bushey

Page 2: What must I do about abnormal LFT? KEVIN ROSENFELD Consultant Radiologist West Hertfordshire Hospitals Spire Hospital Harpenden Spire Hospital Bushey

Abnormal LFT

Symptomatic or incidental finding Symptoms

– Pain,nausea,LOW,known malignancy Ultrasound Pathology

– Gallstones– neoplasm

Page 3: What must I do about abnormal LFT? KEVIN ROSENFELD Consultant Radiologist West Hertfordshire Hospitals Spire Hospital Harpenden Spire Hospital Bushey

Asymptomatic abnormal LFT

Incidental finding

Page 4: What must I do about abnormal LFT? KEVIN ROSENFELD Consultant Radiologist West Hertfordshire Hospitals Spire Hospital Harpenden Spire Hospital Bushey

CASE 1

40 M Insurance medical Bloods:GGT 240 rest bloods normal What do next?

• Ultrasound• GI referral• Counsel patient• nothing

Page 5: What must I do about abnormal LFT? KEVIN ROSENFELD Consultant Radiologist West Hertfordshire Hospitals Spire Hospital Harpenden Spire Hospital Bushey

CASE 2

55F Pneumonia Treated A/B Still unwell Bloods : AST 95 alk phos normal GGT 150 What next

• GI referral• Ultrasound• Stop AB and recheck bloods in 4 weeks

Page 6: What must I do about abnormal LFT? KEVIN ROSENFELD Consultant Radiologist West Hertfordshire Hospitals Spire Hospital Harpenden Spire Hospital Bushey

Management of asymptomatic abnormal LFT

Draft guidelines BSG Not universally accepted West Herts adopted for primary care

Page 7: What must I do about abnormal LFT? KEVIN ROSENFELD Consultant Radiologist West Hertfordshire Hospitals Spire Hospital Harpenden Spire Hospital Bushey

F i g u r e 1 . S u g g e s t e d M a n a g e m e n t o f A b n o r m a l L F T s

C L I N I C A L S I T U A T I O N

A C T I O N S U G G E S T E D

M A N A G E M E N T S U G G E S T E D

A b n o r m a l a l k a l i n e p h o s p h a t a s e o r s e r u m t r a n s a m i n a s e s < 2 x u p p e r l i m i t o f n o r m a l

L I V E R S C R E E N i . e F u l l h i s t o r y , H B S A g , H C V A b ,

1 A T A u t o i m m u n e P r o f i l e , F e r r i t i n , C a e r u l o p l a s m i n , I m m u n o g l o b u l i n s U l t r a s o u n d a b d o m e n

D i l a t e d b i l e d u c t s

2 . S t o p h e p a t o t o x i c d r u g s

3 . A d v i s e w e i g h t l o s s i f B M I > 2 5

5 . R e c h e c k L F T i n 3 - 6 m o n t h s

P E R S I S T E N T L Y A B N O R M A L L F T

I n c r e a s e d G T o n l y A l c o h o l a b s t i n e n c e

I n c r e a s e d B i l i r u b i n o n l y

R e c h e c k w i t h c o n j u g a t e d b i l i r u b i n , e x c l u d e h a e m o l y s i s E

R e a s s u r e a s l i k e l y G i l b e r t s S y n d r o m e

4 . C h e c k G T i f R a i s e d A L P

1 . A l c o h o l a b s t i n e n c e

A l c o h o l a d v i c e

C h o l a n g i o g r a p h y M R C P o r E R C P

N o n - d i l a t e d b i l e d u c t s

C o n s i d e r t r e a t i n g u n d e r l y i n g d i s o r d e r e g P B C , h a e m o c h r o m a t o s i s o r a L i v e r B i o p s y

A b n o r m a l a l k a l i n e p h o s p h a t a s e o r s e r u m t r a n s a m i n a s e s > 2 x u p p e r l i m i t o f n o r m a l

Page 8: What must I do about abnormal LFT? KEVIN ROSENFELD Consultant Radiologist West Hertfordshire Hospitals Spire Hospital Harpenden Spire Hospital Bushey
Page 9: What must I do about abnormal LFT? KEVIN ROSENFELD Consultant Radiologist West Hertfordshire Hospitals Spire Hospital Harpenden Spire Hospital Bushey
Page 10: What must I do about abnormal LFT? KEVIN ROSENFELD Consultant Radiologist West Hertfordshire Hospitals Spire Hospital Harpenden Spire Hospital Bushey
Page 11: What must I do about abnormal LFT? KEVIN ROSENFELD Consultant Radiologist West Hertfordshire Hospitals Spire Hospital Harpenden Spire Hospital Bushey

Liver Metastases U/S

Page 12: What must I do about abnormal LFT? KEVIN ROSENFELD Consultant Radiologist West Hertfordshire Hospitals Spire Hospital Harpenden Spire Hospital Bushey

Liver Metastases CT

Page 13: What must I do about abnormal LFT? KEVIN ROSENFELD Consultant Radiologist West Hertfordshire Hospitals Spire Hospital Harpenden Spire Hospital Bushey

Fatty Liver

Common ultrasound finding

Page 14: What must I do about abnormal LFT? KEVIN ROSENFELD Consultant Radiologist West Hertfordshire Hospitals Spire Hospital Harpenden Spire Hospital Bushey

F i g u r e 1 . S u g g e s t e d M a n a g e m e n t o f A b n o r m a l L F T s

C L I N I C A L S I T U A T I O N

A C T I O N S U G G E S T E D

M A N A G E M E N T S U G G E S T E D

A b n o r m a l a l k a l i n e p h o s p h a t a s e o r s e r u m t r a n s a m i n a s e s < 2 x u p p e r l i m i t o f n o r m a l

L I V E R S C R E E N i . e F u l l h i s t o r y , H B S A g , H C V A b ,

1 A T A u t o i m m u n e P r o f i l e , F e r r i t i n , C a e r u l o p l a s m i n , I m m u n o g l o b u l i n s U l t r a s o u n d a b d o m e n

D i l a t e d b i l e d u c t s

2 . S t o p h e p a t o t o x i c d r u g s

3 . A d v i s e w e i g h t l o s s i f B M I > 2 5

5 . R e c h e c k L F T i n 3 - 6 m o n t h s

P E R S I S T E N T L Y A B N O R M A L L F T

I n c r e a s e d G T o n l y A l c o h o l a b s t i n e n c e

I n c r e a s e d B i l i r u b i n o n l y

R e c h e c k w i t h c o n j u g a t e d b i l i r u b i n , e x c l u d e h a e m o l y s i s E

R e a s s u r e a s l i k e l y G i l b e r t s S y n d r o m e

4 . C h e c k G T i f R a i s e d A L P

1 . A l c o h o l a b s t i n e n c e

A l c o h o l a d v i c e

C h o l a n g i o g r a p h y M R C P o r E R C P

N o n - d i l a t e d b i l e d u c t s

C o n s i d e r t r e a t i n g u n d e r l y i n g d i s o r d e r e g P B C , h a e m o c h r o m a t o s i s o r a L i v e r B i o p s y

A b n o r m a l a l k a l i n e p h o s p h a t a s e o r s e r u m t r a n s a m i n a s e s > 2 x u p p e r l i m i t o f n o r m a l