what is the right diet for ibd? - johns hopkins hospital to discuss the role of dietary therapy and...
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What is the Right Diet for IBD?
Gerard E. Mullin, M.D.
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Objectives
To discuss the role of dietary therapy and counseling for IBDTo discuss the popular named diets used by IBD patientsNutrition management in PediatricsTo discuss the appropriate use of nutraceuticals supplements for IBD
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Diets for IBD
No standard IBD diet currently existsSeveral “named” diets having testimonials– Elimination Diet– Specific Carbohydrate Diet– Maker’s Diet– Anti-inflammatory Diet
Limited guidance from professional societies plenty of divergent information on the internet
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Named Diets for IBDDiet Rationale Plan Evidence
Elimination Lower antigenic burden-up to 66% of CD pts. report food intolerances 1
Eliminate known and suspected provocative foods 2-4 weeks then reintroduce: 1 new food per day-process maytake 2-3 months
Mishkin S.Am J Clin Nutr. 1997 Feb;65(2):564-7.Giaffer MH, Cann P, Holdsworth CD.Aliment PharmacolTher. 1991 Apr;5(2):115-25
Specific Carbohydrate Diet
Eliminate poorlydigestible CHO’s to limit fermentation in small bowel.Avoid Complex carbohydrates
Allowed: meat, fish, eggs, vegetables, nuts, low-sugar fruitsAvoid: starches, grains, pasta, legumes, and breads
none
Maker’s Diet 40 day diet and lifestyle regimen based upon “biblical principles”
“clean” non-processed diet, lifestyle, spiritual, mental, emotional
none
Anti-inflammatory Diet Provide foods rich in flavonoids and phytonutrients
Avoid red meat, dairy-favor vegetables, fish, olive oil, walnuts, etc.
none
1. Brown AC, Roy M. Does evidence exist to include dietary therapy in the treatment of Crohn’s disease? Expert Rev. Gastroenterol. Hepatol.4(2),191–215 (2010).
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General IBD guidelines from the American Dietetic Association.
Eat small meals or snacks every 3 or 4 hours.Use low fiber foods when you have symptoms. You can slowly reintroduce small amounts of whole grain foods and higher-fiber fruits and vegetables one at a time when symptoms improve. Drink enough fluids (at least 8 cups each day) to avoid dehydration. Eat foods with added probiotics and prebiotics. Use a multivitamin. During periods when you don’t have symptoms, include whole grains and a variety of fruits and vegetables in your eating plan. Start new foods one at a time, in small amounts.
Bernstein CN, Fried M, Krabshuis JH et al. World Gastroenterology Organization Practice Guidelines for the diagnosis and management of IBD in 2010. Inflamm. Bowel Dis. 16(1), 112-24 (2010).
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Dietary Guidelines for IBDNo special diet has been proven to be effective for preventing or treating CD symptoms or inflammationDuring disease activity
– Decrease fiber consumption especially whole-grain products, bran, beans, brown rice, wild rice, nuts, corn, corn hulls, popcorn, seeds, raw fruits and certain vegetables (prunes, corn, raw greens, cabbage and brassica family
– During recovery period (no symptoms), slowly reintroduce high-fiber foods one at a time in small amounts. Those with blocked intestines may need to avoid raw fruits and vegetables.
Maintain dairy products unless intolerance develops Enteral nutrition should be used as an adjunct to medical therapy in those who are unable to maintain their nutrition status through oral intake
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Minimal Lactose Diet
Foods AllowedReduced lactose milkYogurtSoya milkButter, some margarinesDouble Cream cheese
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Minimal Lactose Diet cont.Foods to AvoidMilkIce creamMargarine (need to check ingredients)Cream (except double cream)Cottage cheese, processed cheese and cheese spreadsMalted milk drinks and drinking chocolateMilk chocolate, fudge, toffeeCheck ingredients for lactose, milk, milk powder etc.
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Healthy Diet for IBDKeep up with energy needs seek medical attention if you loose >5% of body weight in 6 weeks or 10% body weight in 6 monthsEat a well-balanced diet-avoid being overly restrictiveFor Crohn’s Disease– Lactose and fructose intolerance is frequent with
small bowel Crohn’s Disease– Low fiber diet for stricturing and obstructive disease– For food intolerances consider seeking nutritional
counseling for a supervised elimination dietUlcerative colitis-no specific dietary recomendations
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Sources of Fructose
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Nutrition Support
Oral Diet
Oral Supplements
Specialized Nutrition Support
Enteral Nutrition
Parenteral Nutrition
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Liquid DietsElemental/Semi-Elemental (hydrolyzed)– Predigested into amino acids-dipeptides, non-lactose
simple sugars (monosaccharides), readily absorbable fats (medium-chain triglycerides)
Polymeric (intact nutrients)– Glucose polymers, long chain fats, proteins– More palatable than elemental, semi-elemental– Stimulate growth and healing of gut
Tube Feeds– Polymeric formulations delivered though a tube into
the gut
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Enteral Nutrition (Liquid Diet)Mechanisms of Action?
Enteral Nutrition
Gut Permeability
Bowel Rest
Glutamine
Antigenic Load
Fat Composition
Gut Flora
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Typical Candidate Patient for EN (Liquid Diet) Therapy
Child with malnutritionChild with growth failureChild with small bowel involvement colonic diseaseChild with intolerable corticosteroid side effects
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EN for Treatment of Active CDIn adults, not as efficacious as corticosteroids in inducing remission; better outcomes in childrenEN should be given 6-10 weeks exclusively (oral up to 600 Kcal/D)May require nasogastric tube for administrationBenefits include corticosteroid sparing and promotion of growth in children
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ROUTE GOAL OUTCOME
Enteral(Liquid diet)
Primary TxMainly Pediatric
Remission-recurrence with oral diet
Reversal of Growth Failure
Achieves growth in children and adolescents
ROLE OF NUTRITION SUPPORT IN CD
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ROLE OF TPN IN CD
ROUTE GOAL OUTCOME
Parenteral Short Bowel Syndrome
Intolerance-malabsorption of enteral nutrition
Fistula closure Remission-recurrence with enteral nutrition
PreoperativeRehabilitation
Corrects malnutritionDecreases complications in severely malnourished
Reversal of Growth Failure
Achieves growth in children and adolescents intolerant to enteral nutr.
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Enteral > PlaceboEnteral < GCSEnteral = TPN
Polymeric = Elemental
Effectiveness of Nutritional Support for Crohn’s Disease
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MALNUTRITION IN IBDDeficiency CD UC Treatment
Negative nitrogen balance
69% Unknown Adequate energy and protein
Vitamin B12 48% 5% 1000 mcg/d x 7 d then Q mo
*Folate 67% 30-40% 1 mg/dVitamin A 11% Unknown 5,000-25,000 IU/d*Vitamin D 75% 35% 5,000-25,000 IU/d
Calcium 13% Unknown 1,000-1,200 mg/D
Potassium 5-20% Unknown VariableIron 39% 81% Fe Gluconate 300 mg TIDZinc 50% Unknown Zn Sulfate 220 mg daily or
BID
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Vitamin Supplements for IBD
Patients with CD and UC tend to have vitamin and mineral deficiencies (B12, folate, vitamin D, zinc, calcium, iron).Consider a multivitamin multimineral supplementTake calcium-vitamin D supplement as per DRI (1200 mg calcium 400 IU vitamin D)Be wary of taking mega-doses of vitamins to control disease!
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Danger of Megadosing Supplements
Vitamin A toxicity-cirrhosis, bone painVitamin E-bleeding, diarrhea, crampingFish Oil-bleeding tendencyZinc-copper deficiencyVitamin D-kidney stonesB vitamins– B1 (thiamine) cardiac arrhythmias– B3 (niacin) flushing– B6 (pyridoxine) peripheral neuropathy
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Nutraceutical Supplementsfor IBD
Modality Dose _____________Omega-3 fatty acids 3-4000 mg/DBoswelia 350 mg 3x/DCurcumin 1000 mg 2X/DProbiotics 30 billion CFU/DPrebiotics variesButyrate enemas 60-100 mL 60-80 microM/L
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If in Doubt Seek a Qualified Nutritionist for Advice
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ConclusionsLack of expert consensus on diet for IBDEnteral nutrition may induce remission and maintain growth curve in childrenTPN-mainly for perioperative malnourished, fistula, short gut syndromeProbiotics, SCFA enemas and Curcumin may be useful adjuncts for UCFish oils may help maintain CDSupplements are adjuncts not substitutes for medical Txfor IBD
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QUESTIONS?