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Origin What it becomes Signal involved

Paraxial mesoderm Somites

Dermomyotome Dermis and muscle

Intermediate mesoderm Dermomyotome and sclertome SHH and Wnt

Dorsomedial myotome epaxial muscles around spine

Ventrolateral mytomome hypaxial muscles overtop epaxial

Ectoderm + dermatone Integument

Lateral plate mesoderm Limbs

Somites Vertebrae

Proximal ribs Pd! + ""

Distal rib #$P

%otochord %ucleus pulposis

!emaining schlerotome annulis &ibrosis

Sclerotome vertebrae

'avitation o& lateral plate mesoderminitial body cavity (embryonic body cavity)

somatic layer beneath ectoderm

splanchnic layer over endoderm

Ectoderm + someatic mesoderm somatopleura

Endoderm + splanchnic mesoderm Splanchnopleure

Pleuropericardial separate pericardial sac and pleural cavities hori*ontal &olding &rom lungs

pleuroperitoneal separate pleural cavities &orm peritoneal cavities vertical &olding &orm lungs

Embryonic body cavity

single layer pericardial

single layer peritoneal

double layer pleural

Wnt (&rom ectoderm) a&ter SHH &romnotochord

Hox genes (more involved &or caudalvertebrae)

hox genes signalling endochondralossi&cation

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#ody all musc Diaphragm

,ransverse septum 'entral tendon

$esentary esophagus !ight and Le&t crura

vertebrocostal triangle

Precardiac mesoderm ,ubular heart

Endocardial tubes Primite heart bilateral &olding

Primary heart &ield In&lo- le&t ventricle- part o& right ventricle

secondary heart &ield out&lo- part o& right ventricle

cardiac neural crest great vessels

smooth muscle in vaculature

parasympathetic neurons

In&lo sinus venous ../ atria

out&lo bulbis cordis ../ conus0truncus arteriosus

proepicardial organ &ibroblasts- coronary vessels- epicardium E%,

dorsal heart all toards cushions Setptum primum ith &oramen primum

endocardial prominences and conotruncus 1V cushions E%,

Septum primum &oramen secundum apoptosis causing per&orations

$uscular IV septum ith IV &ormaen

IV &oramen membranous IV septum

septum secundum ith &oramen ovale

septum primum valve o& &oramen ovale#ulbar truncal ridges aortic and pulmonary out&lo E%,

&usion o& PP + transv septum + mesent2

Esophagus

through pharg arches 3-4-5 to createaorticopulmonary septum

 1pex o& heart moving to cushions and bulbarridge

crescent movement over septum primum and&orament secundum toards cushions

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#ulbis cordisright vent6 pulmonary trun7

le&t ventricle6 aortic vestibule

Subendocardial prominences semilunar valves

P11 8 part o& maxillary artery

P11 9 part o& hyoid and stapedial

P11 3 ventral common carotid- dorsal internal carotid

P11 4 rt : prox subclavian- lt : part o& aortic arch

P11 ; rudimentary vessel

P11 5

!ecurrent laryngeal 5th P11 dev

Vitelline veins rt : hepatic portal hepatic sinusoids brea7 up veins

umbilical lt : ductus venous path through liver ../ IV'

'ardinal

 1nastomose bt anterior l0r le&t brachiocephalic vein

right anterior cardinal right brachiocephalic vein

posterior cardinal subcardinal- supracardinal- sacrocardinal

subcardinal 7idney anastomose (renal IV' and assoc veins)

supracardinal rt2 1*ygos< lt2 hemi*ygos- sup intercost

sacrocardinal

common cardinal

Ductus venosus ligamentum venosum

u=mbilical artery ligamentum teres

Ductus arteriosus Ligamentum arteriosus

rt : part o& rt pulm artery< lt : part o& lt pulmonary artand ductus arteriosus

right side hoo7s around rt subclavian and le&t hoo7saround ductus art

anastome bt sub0supracardinal< lumbar IV'-common iliac veins

 >oin ant0post cardinals< rt : SV'< lt : obli?ue vein (parto& coronary sinus)

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Problems?

'ervical rib

#loc7 vertebrae (D"5 mutation)-hemivertebrae - sagittal cle&t

congential diaphragmatic hernia due to slogroth

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congential diaph hernia due to &ailure o& &usion

,bx- $e&.9- %@A9- Hand- ata

eventration o& diaph due to lac7 o& musculature

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 #ppendix

$ntermediate Mesoderm %ephrogenic and genital ridges

%ephrogenic cord Mesonephric tubules

#orta gives branch &&' glomerulus

Metanephr mesenchyme Metanep kidney (retic bud contacts it

#llantois (rachus )bliteration of allantois

(rogenital sinus

Vesicle part bladder

*elvic partmale+ prostatic urethra

female+ entire urethra

*hallic part male+ spongy urethra

 ,rigone bladder

Mesonephric ducts -.ol/an0

Males+ ductus deferens

1emale+ round ligament of ovary *assive regression

Mullerian duct Male+ actively regress

1emale+ uterus walls and tubes

Gonad ,estis ,D1 by presence of S23

Gonad )vary .nt 4

Germ cells in dev testis Seminiferous cords

Supporting epithelial cells Sertoli cells Steroidgen factor due to S23

Mesenchyme of gonadal ridge Leydig cells Steroidgen factor due to S23

5xternal genitalia ,est and DH, from leydig

Mullerian inhibiting substancefrom sertoli

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Problems?

#nnular pancreas due to ventral budmoving bilaterally around6

Heterotrophic pancreatic tissue showsup in liver or duodenum due to error in

endoderm dierentiation

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$ncomplete fusion or atresia

!ortex regresses" medulla dier

!ortex dier" medulla regresses

!an be patent if allantois does notcompletely obliterate