wellness & women’s health focus on antioxidants & other … · 2018-03-31 · wellness...
TRANSCRIPT
Wel
lnes
s &
Wo
men
’s H
ealt
h
Focus on Antioxidants & Other
Dietary Supplements
PA
NA
Fal
l S
ym
posi
um
The
Get
tysb
urg
Hote
l
Oct
ober
7, 2006
Pre
sente
d B
y
Cat
hy
Cre
ger
Rose
nbau
m,
Phar
mD
, M
BA
, R
Ph
Cli
nic
al E
ffec
tiven
ess
& S
afet
y O
ffic
er
Tri
Hea
lth
Corp
ora
tion -
Cin
cinnat
i, O
hio
Founder
& C
EO
-R
x I
nte
gra
tive
Solu
tions,
Inc
ww
w.r
xin
tegra
tives
olu
tions.
com
Ob
ject
ives
�A
nal
yze
cli
nic
al e
vid
ence
reg
ard
ing
su
pple
men
t
reg
imen
s to
pre
ven
t/tr
eat
hea
lth-r
elat
ed
con
dit
ion
s in
wo
men
�E
val
uat
e ef
fica
cy, d
osa
ges
, ad
ver
se d
rug
reac
tio
ns,
an
d p
ote
nti
al d
rug/h
erb
in
tera
ctio
ns
rela
ted
to
th
ese
her
bal
pro
du
cts
�M
on
ito
r &
man
age
sup
ple
men
ts, re
ferr
ing
pat
ients
to
a r
epu
tab
le p
har
mac
ist
for
mo
re
info
rmat
ion
Men
opau
se�
Pre
-men
op
ause
, ov
arie
s
pro
duce
est
rad
iol
�P
ost
-men
op
ause
,
extr
agla
ndu
lar
and f
at t
issu
e
pro
duce
est
rone
�S
xs:
vas
om
oto
r, b
reas
t an
d
uro
gen
ital
atro
ph
y,
ost
eop
oro
sis
�H
RT
–b
reas
t an
d u
teri
ne
can
cer,
↑ri
sk o
f
card
iov
ascu
lar
even
ts
�W
hat
ab
ou
t phyto
estr
og
ens?
Ph
yto
estr
og
ens
Ph
eno
lics
Fla
vo
no
ids
(cat
ech
in)
Iso
flo
vo
no
ids
Iso
flav
on
esC
ou
mes
tan
s
Gen
este
inD
aid
zein
Ph
yto
estr
og
ens
�N
on
-ste
roid
al p
lant
com
po
un
ds
that
bin
d t
o
estr
og
en r
ecep
tors
wit
h 1
/100
0 t
he
affi
nit
y o
f es
trad
iol
�W
eak
ly e
stro
gen
ic a
nd
an
ti-e
stro
gen
ic d
epen
din
g
on
do
se, am
ou
nt
of
end
og
eno
us
sex
ho
rmo
nes
, an
d t
he
targ
et o
rgan
in
vo
lved
�C
lass
es:
iso
flav
on
es(m
ain
), l
ign
ans
(no
n
ph
enoli
c), co
um
esta
ns,
sap
on
ins
(no
n p
hen
oli
c)
�A
mer
ican
Men
op
ausa
l S
oci
ety
po
siti
on
sta
tem
ent
Fla
vo
no
ids
(su
bcl
ass
of
po
lyp
hen
ols
)
�~
50
00
�S
ix m
ajor
cate
gori
es:
�1
. F
lav
ono
ls(c
atec
hin
, ep
icat
ech
in):
ch
oco
late
, te
a, r
ed w
ine,
bea
ns,
ap
rico
t, c
her
ry, gra
pe,
pea
ch, b
lack
ber
ry,
app
le
�2
. F
lavo
non
es(h
esp
eret
in, n
arin
gen
in, er
iodic
tyo
l):
citr
us
fruit
s an
d
juic
es
�3
. F
lavo
nes
(ap
igen
in, lu
teoli
n):
par
sley
, ce
lery
�4
. I
sofl
avon
es(d
aid
zein
, g
enis
tein
): s
oy
�5
. M
ore
Fla
von
ols
(qu
erce
tin,
kae
mpfe
rol,
myri
ceti
n):
on
ions,
kal
e,
bro
cco
li,
tom
ato
, b
lueb
erry
, ap
ple
s, t
ea, re
d w
ine
�6
. A
nth
ocy
anid
ins
(cyan
idin
, p
elar
gon
idin
, p
eon
idin
, d
elph
inid
in,
mal
vid
in):
blu
eber
ry, b
lack
gra
pe,
ch
erry
, b
lack
ber
ry, b
lack
curr
ant,
rh
ub
arb,
stra
wb
erry
, re
d w
ine,
plu
m,
red c
abb
age
Iso
flav
ones
�Is
ofl
avono
ids,
a c
lass
of
com
poun
ds
wit
h a
div
erse
ran
ge
of
acti
vit
ies
stru
ctura
lly d
isti
nct
fro
m p
hyto
estr
og
ens
(i.e
., g
enes
tein
, d
aid
zein
, b
ioch
anin
A, fo
rmon
on
ecti
n, p
uer
arin
)
�A
s an
tio
xid
ants
, re
du
ce R
OS
, re
du
ce R
NS
, in
crea
se N
O
�S
om
e is
ofl
avon
esre
sem
ble
est
rog
enic
an
d a
nti
-est
rogen
ic c
om
pou
nd
s li
ke
SE
RM
S
�G
enis
tein
and d
aid
zein
are
fou
nd
in s
oyb
eans,
red
clo
ver
, ku
dzu
roo
t b
oun
d t
o g
luco
se a
s th
e in
acti
ve
gly
cosi
des
�In
test
inal
glu
cosi
das
esh
ydro
lyze
th
e g
lyco
sid
es t
o a
ctiv
e ag
lyco
ne
com
pou
nd
s
�W
om
en m
etab
oli
ze i
sofl
avones
bet
ter
than
men
�E
ffec
ts o
f is
ofl
avon
eso
n b
reas
t ca
nce
r u
ncl
ear,
esp
ecia
lly e
stro
gen
-re
cep
tor
po
siti
ve
�D
I: M
ay c
oun
tera
ct t
amo
xif
enin
th
eory
�M
ost
act
ive
iso
flav
on
ein
so
y
�S
tru
ctu
rall
y s
imil
ar t
o 1
7β-
estr
adio
l (1
/100
-1/1
00
0)
�B
ind
s to
ERβ
rece
pto
r w
ith
gre
ater
aff
init
y t
han
E
Rα
, b
ut
also
an
ti-e
stro
gen
ic d
epen
din
g o
n t
issu
e ty
pes
(ra
t)
�C
an a
lter
ex
pre
ssio
n o
f p
rog
este
ron
e re
cep
tor,
th
e an
dro
gen
rec
epto
r, a
nd
th
e o
xyto
cin
rece
pto
r
�In
trac
ellu
larl
y, in
hib
its
tyro
sin
e k
inas
es
�A
ffec
ts c
ell
cycl
e b
y i
nhib
itin
g D
NA
to
pois
om
eras
esI
and
II
(lik
e V
P-1
6)
�Is
ofl
avon
esm
ay p
rom
ote
can
cer
cell
gro
wth
at
low
er
do
ses
(Liu
20
05
Can
cer
Res
earc
h)
Gen
este
in
Lig
nan
s
�N
on
-phen
oli
cp
lan
t co
mpou
nd
s w
ith
ver
y
wea
k e
stro
gen
ic a
nd
an
ti-e
stro
gen
ic
acti
vit
y
�E
nte
rola
cto
ne
�F
ound
in
fru
its,
veg
etab
les,
who
le g
rain
s,
flax
seed
, so
yb
ean
sp
rou
ts
Cou
mes
tan
s
�P
lan
t co
mpou
nd
s
�C
om
pet
e w
ith e
stra
dio
lfo
r es
trog
en-
rece
pto
r b
ind
ing s
ites
, re
sult
ing i
n h
igher
circ
ula
ting
est
rad
iol
con
cen
trat
ion
s
�F
ound
in
alf
alfa
spro
uts
and c
lov
er s
eed
s
�N
ot
wel
l re
sear
ched
So
y�
So
yb
ean
s >
tofu
> s
oy m
ilk r
egar
din
g i
sofl
avo
ne
con
cen
trat
ion
�G
enis
tein
and d
aid
zein
bin
d t
o b
oth
α-
(exp
ress
ed i
n b
reas
t an
d
ov
aria
n c
ance
r ce
ll l
ines
) an
d β
-est
rog
en r
ecep
tors
(ex
pre
ssed
in
norm
al b
reas
t, u
teri
ne,
ov
aria
n t
issu
e)
�E
pid
emio
log
y:
low
er p
rev
alen
ce o
f v
aso
mo
tor
sym
pto
ms
in
popu
lati
on
s th
at e
at i
sofl
avo
ne-
rich
die
ts
�H
ot
flas
h r
educt
ion
not
sup
po
rted
by c
linic
al d
ata;
FD
A a
ppro
ved
for
cho
lest
ero
l lo
wer
ing
�D
ose
:20-6
0 g
ram
s/d
ay s
oy p
rote
in p
rov
idin
g 3
4-7
6 m
g i
sofl
avon
es
(1/4
blo
ck t
ofu
, ¼
cup s
oy f
lou
r)
�5
0 g
ram
s so
y =
50
-15
0 m
g i
sofl
avon
es
�S
E –
GI
rela
ted
Bla
ck C
oh
osh
�S
tand
ardiz
ed t
o 1
mg
tri
terp
ene
gly
cosi
des
cal
cula
ted
as
27-
deo
xyac
etin
(R
emif
emin
) do
se a
s 40
mg
bid
�N
ot
stu
die
d b
eyo
nd
six
mo
nth
s
�M
OA
unk
no
wn
�V
aria
ble
eff
ects
on
LH
; n
o e
ffec
t on
FS
H, L
H,
sex-h
orm
one
bin
din
g
glo
bu
lin
, pro
lact
in, or
estr
adio
lin
po
st-m
eno
pau
sal
wo
men
�M
ay h
ave
sele
ctiv
ity f
or
estr
og
en r
ecep
tors
, b
ind
ing
in b
one
bu
tno
t u
teru
s
�O
pen
lab
el t
rial
s w
itho
ut
pla
ceb
o a
rms
rep
ort
ing
posi
tiv
e ef
fect
s on
sy
mp
tom
s
�T
wo
sm
all
tria
ls c
om
par
ed i
t w
ith H
RT
wit
h m
ixed
res
ult
s
�M
ay b
e ca
rcin
og
enic
in m
ice
�S
E –
nau
sea,
diz
zin
ess,
hea
dac
he
Wh
at I
s O
xid
ativ
e S
tres
s an
d W
hat
Ro
le D
o A
nti
ox
idan
ts P
lay
In
It?
�O
xygen
fre
e ra
dic
als
are
mole
cule
s w
ith a
n u
npai
red
elec
tron c
reat
ed d
uri
ng n
orm
al b
ody m
etab
oli
sm
�F
ree
radic
als
pro
mote
good o
xid
atio
n t
hat
pro
duce
s en
ergy a
nd k
ills
bac
teri
a
�In
exce
ss, oxygen
fre
e ra
dic
als
get
into
cel
l m
embra
nes
, ca
n c
ause
cel
l dam
age
(oxid
ativ
e st
ress
), a
nd o
ver
tim
e m
ay i
ncr
ease
ris
k o
f ca
nce
r or
card
iovas
cula
r dis
ease
�A
nti
oxid
ants
counte
ract
fre
e ra
dic
als
in t
he
cell
s to
pro
tect
th
em
�T
he
body m
akes
its
ow
n a
nti
oxid
ants
incl
udin
g
eryth
rocy
te s
uper
oxid
edis
muta
sean
d o
ther
enzy
mes
An
tio
xid
ants
in
Die
tary
Su
pp
lem
ents
�V
itam
in A
(ca
rrots
, sp
inac
h, sw
eet
pota
to)
**
�B
eta
Car
ote
ne
(ora
nge/
yel
low
veg
etab
les)
**
�V
itam
in E
(eg
gs,
alm
on
ds,
wal
nuts
, oli
ve
oil
, as
par
agus,
sw
eet
pota
to)
**
�V
itam
in C
(O
J, g
reen
pep
per
, ra
spber
ry, to
mat
o)
�S
elen
ium
(tu
na,
turk
ey, oat
mea
l, r
ice,
wal
nuts
, bra
zil
nuts
)
�L
yco
pen
e(t
om
ato)
**
�C
oen
zym
e Q
10 (
rice
bra
n, so
y, se
sam
e se
eds,
sar
din
es)
**
�S
oy I
sofl
avones
(Gen
iste
inan
d D
aidze
in)
�T
urm
eric
(C
urc
um
in)
(curr
y)
�N
-Ace
tyl
Cyst
eine
–boost
s glu
tath
ione
�P
hyto
estr
ogen
s(y
ams,
soy)
�G
reen
Tea
Poly
phen
ols
(EC
GC
)
________________________________________________
** =
fat
solu
ble
Hu
ang.
Th
e ef
fica
cy a
nd s
afet
y o
f m
ult
ivit
amin
an
d m
iner
al
sup
ple
men
t use
to p
rev
ent
can
cer
and c
hro
nic
dis
ease
in
adu
lts:
a
syst
emat
ic r
evie
w f
or
a N
atio
nal
In
stit
ute
s of
Hea
lth
stat
e-of-
the-
scie
nce
con
fere
nce
. A
nn
Inte
rn M
ed 2
006
;145
:372
.
�Jo
hns
Hopkin
s under
contr
act
to A
HR
Q N
IH f
un
ded
�7 e
ffic
acy R
CT
’s, 5 e
ffic
acy &
saf
ety R
CT
san
d 3
saf
ety-
rela
ted c
ase
report
s
�D
efin
itio
n M
VI
& m
iner
al s
upple
men
ts:
≥3 v
itam
ins
or
min
eral
s w
ithout
her
bs,
horm
ones
, o
r dru
gs
�L
imit
atio
ns:
RC
Ts
only
for
effi
cacy
; fi
ndin
gs
may
not
apply
to u
se o
f co
mm
erci
al M
VI
by g
ener
al p
opula
tion
�C
oncl
usi
ons:
“ev
iden
ce i
s in
suff
icie
nt
to p
rove
the
pre
sence
or
abse
nce
of
ben
efit
s fr
om
the
use
of
MV
I &
m
iner
al s
upple
men
ts t
o p
reven
t ca
nce
r an
d c
hro
nic
il
lnes
s”
Her
cber
g. S
U.V
I.M
AX
Stu
dy. A
ran
dom
ized
, pla
cebo-
contr
oll
ed t
rial
of
the
hea
lth e
ffec
ts o
f an
tioxid
ant
vit
amin
s
and m
iner
als.
Arc
h I
nte
rn M
ed 2
004
�N
= 1
301
7 p
atie
nts
no
t se
lect
ed f
or
risk
fac
tors
�W
om
en (
35 –
60 y
ears
), m
en (
45 –
60
yea
rs)
�V
itam
in C
12
0 m
g,
Vit
amin
E 3
0 m
g,
Bet
a-ca
rote
ne
6 m
g, S
elen
ium
100
mcg
, Z
inc
20 m
g v
sp
lace
bo-
pre
ven
tion
�E
ndpo
ints
: pre
ven
tion
of
all-
site
can
cers
, is
chem
ic h
eart
dis
ease
, an
d
all
cause
mort
alit
y
�R
esu
lts:
aft
er 7
.5 y
ears
, lo
w d
ose
an
tiox
idan
t su
pp
lem
ents
lo
wer
ed
tota
l ca
nce
r in
cid
ence
an
d a
ll c
ause
mo
rtal
ity i
n m
en,
no
t w
om
enb
ased
on
rel
ativ
e ri
sk w
hen
str
atif
ied
by g
end
er
�M
ay b
e du
e to
lo
wer
bas
elin
e an
tio
xid
ant
stat
us
in m
en t
han
wo
men
�L
imit
atio
n:
nee
d b
iom
ark
er r
esea
rch
or
bio
psy
tis
sue
to e
stab
lish
th
at
inte
rven
tion
agen
t re
ach
es t
he
targ
et t
issu
e in
an
appro
pri
ate
con
cen
trat
ion
Bro
wn
. S
imv
asta
tin
and
nia
cin
, an
tio
xid
ant
vit
amin
s, o
r th
e co
mb
inat
ion
for
the
pre
ven
tio
n o
f
coro
nar
y d
isea
se. N
EJM
20
01
; 3
45:
15
83
.
�H
DL
-Ath
erosc
lero
sis
Tre
atm
ent
Stu
dy
(H
AT
S),
NIH
gra
nt;
RC
T, 3 y
ears
�N
= 1
60,
≥3 s
tenose
sof
at l
east
30%
of
lum
inal
dia
met
er o
r one
sten
osi
sof
at l
east
50%
�G
rp1:
Zoco
r+
nia
cin (
max
4 g
ram
s dai
ly)
�G
rp2:
Anti
oxid
ant
vit
amin
s (8
00 I
U v
itE
, 1000 m
g v
itC
,
25 m
g b
eta
caro
tene,
100 m
cg s
elen
ium
)
�G
rp3:
Zoco
r+
nia
cin +
anti
oxid
ant
vit
amin
s
�G
rp4:
Pla
cebo
�E
ndpoin
ts:
chan
ge
in c
oro
nar
y s
tenosi
san
d o
ccurr
ence
of
dea
th, M
I, s
troke,
or
revas
ula
riza
tion
�R
esult
s: N
o c
han
ge
in c
hole
ster
ol
in G
rps
2 +
4. S
ignif
ican
t posi
tive
chan
ge
in c
hole
ster
ol
in G
rp1. S
tenosi
spro
gre
ssed
4%
in G
rp4 (
p =
0.1
6)
and 1
.8%
in
Grp
2 (
p =
0.0
04).
Ste
nosi
sre
gre
ssed
0.4
% i
n G
rp1 (
p <
0.0
01).
F
requen
cy o
f cl
inic
al e
ndpoin
ts 2
4%
in G
rp4, 3%
in G
rp1, 21%
in G
rp2,
and 1
4%
in G
rp3.
Ost
eoar
thri
tis
-G
luco
sam
ine
Su
lfat
e�
Not
an h
erbal
pro
duct
�C
ellu
lose
der
ivat
ive
�n-a
cety
l-glu
cosa
min
e(N
AG
) or
HC
L d
iffe
rent
chem
ical
form
s of
glu
cosa
min
enot
as w
ell
abso
rbed
as
sulf
ate
�U
se i
n O
steo
arth
riti
s-pro
gre
ssiv
e deg
ener
atio
n o
f ca
rtil
age
gly
cosa
min
ogly
cans
(GA
G)
�M
OA
theo
ry-p
rovid
e ex
ogen
ous
regen
erat
ion o
f ca
rtil
age
for
arth
riti
s or
pre
dnis
one-
induce
d j
oin
t dis
ease
�S
tudy:
212 p
atie
nts
wit
h k
nee
ost
eoar
thri
tis
–1500 m
g g
luco
sam
ine
sulf
ate
or
pla
cebo e
ver
day
x 3
yea
rs. In
The
Lan
cet
Januar
y 2
7, 2001
�N
ew 2
005 N
IH s
tudy w
ith g
luco
sam
ine
HC
L 5
00 m
g t
id–
no i
mpro
vem
ent
in
knee
pai
n e
xce
pt
in s
mal
l gro
up w
ho h
ad m
oder
ate
to s
ever
e pai
n
�D
ose
: 500 m
g t
id–
500 m
g d
aily
aft
er 2
-3 m
onth
s, c
om
bin
ed w
ith f
luid
s an
d
exer
cise
�S
E:
incr
ease
d b
lood s
ugar
(w
hat
about
type
II d
iabet
ics)
, hea
rtburn
�C
I: a
ller
gic
to s
hel
lfis
h c
hit
in
Ost
eoar
thri
tis
-C
ho
nd
roit
in
�M
OA
–in
crea
ses
wat
er i
n j
oin
ts b
y s
tim
ula
ting
pro
duct
ive
of
hyal
uro
nic
acid
by s
ynovia
lce
lls
�F
rom
shar
k c
arti
lage
or
bovin
e tr
achea
�C
hondro
itin
sulf
ates
are
str
uct
ura
lly r
elat
ed t
o L
MW
hep
aran
oid
, dan
apro
id(O
rgar
an)
�S
ulf
ates
are
lar
ge
mole
cule
s, n
ot
wel
l ab
sorb
ed
�T
akes
2-3
month
s to
work
�A
E’s
–nau
sea,
HA
, an
ti-p
late
let
�D
I –
Cou
mad
in, N
SA
IDs,
Pla
vix
, et
c
�F
ound i
n c
om
bin
atio
n w
ith g
luco
sam
ine
sulf
ate
and M
SM
Ost
eoar
thri
tis
-
Met
hy
l S
ulf
on
yl
Met
han
e (M
SM
)�
Sulf
ur
donor,
der
ived
fro
m D
MS
O
�A
nti
-infl
amm
atory
agen
t on m
usc
le (
by
lim
itin
g r
elea
se o
f in
flam
mat
ory
m
edia
tors
) an
d a
nal
ges
ic o
n C
ner
ve
fiber
s; m
ay a
lso i
ncr
ease
blo
od f
low
, re
duce
musc
ula
r sp
asm
�N
ot
dis
ease
modif
yin
g;
sourc
e of
bio
logic
al s
ulf
ur
(com
ponen
t of
pro
tein
s,
connec
tive
tiss
ues
, horm
ones
, en
zym
es)
�L
ong-t
erm
eff
ects
unknow
n
�D
ose
: 500 m
g –
1,0
00 m
g d
aily
�S
ide
Eff
ects
: upse
t st
om
ach
�D
rug I
nte
ract
ions:
oth
er a
nal
ges
ics
�_
__
__
___
___
___
__
__
__
___
___
___
__
__
__
___
___
___
__
__
__
___
___
�1. S
ack K
E. I
s glu
cosa
min
eM
SM
eff
ecti
ve
for
ost
eoar
thri
tis?
P
ost
gra
dM
ed 2
006 J
ul-
Aug;1
19:9
7-9
8
�2. K
im L
S. E
ffic
acy o
f m
eth
yls
ulf
on
ylm
eth
ane
(MS
M)
in o
steo
arth
riti
s p
ain o
f th
e kn
ee:
a pil
ot
clin
ical
tri
al.
Ost
eoar
thri
tis
cart
ilag
e. 2
006 M
ar;1
4:2
86-9
4.
�3. R
obb-N
ichols
on C
. B
y t
he
way, doct
or.
Is
MS
M a
s good a
s it
sounds?
H
arv
Wom
ens
Hea
lth W
atch
2002;
Aug;9
:8
Ost
eoar
thri
tis
-G
ing
er
�A
ltm
an. E
ffec
ts o
f a
gin
ger
extr
act
on k
nee
pai
n i
n p
atie
nts
wit
h
ost
eoar
thri
tis.
A
rthri
tis
& R
heu
m 2
001;4
4:2
531-2
538.
�N
= 2
47 k
nee
pat
ients
�255 m
g g
inger
extr
act,
or
pla
cebo b
id x
6 w
eeks
�R
esult
s –
reduce
d k
nee
pai
n o
n s
tandin
g (
p =
0.0
48)
�A
E’s
–m
ild G
I ef
fect
s
�B
liddal
. A
ran
dom
ized
, pla
cebo-c
ontr
oll
ed, cr
oss
-over
stu
dy
of
gin
ger
ex
trac
ts a
nd i
bupro
fen i
n o
steo
arth
riti
s. O
steo
arth
& C
arti
l2000;8
:9-1
2.
�N
= 7
5 H
ip o
r knee
pat
ients
�170 m
g g
inger
extr
act,
ibupro
fen 4
00 m
g,
or
pla
cebo t
idx 3
wee
ks
each
�R
esult
s –
ibupro
fen >
gin
ger
or
pla
cebo
�N
o d
iffe
rence
bet
wee
n g
inger
extr
act
and p
lace
bo i
n a
tes
t fo
r m
ult
iple
co
mpar
isons
�N
o s
erio
us
adver
se e
ven
ts;
bru
isin
g/b
leed
ing p
oss
ible
due
to e
ffec
ts o
n
pla
tele
ts
Tu
rmer
ic R
oo
t (C
urc
um
a lo
ng
a)�
Cu
rcu
min
(curr
y)
–vo
lati
le o
il;
Curc
um
ino
idco
mp
ou
nd
s in
clu
de
tum
eron
e, a
tlan
ton
e, d
iary
ldep
tan
oid
s, z
ingib
eron
e
�A
nti
ox
idan
t pro
per
ties
no
ted
in
ph
eno
lic
frac
tion
(cu
rcu
min
oid
s)
iso
late
d f
rom
a l
iqu
id e
xtr
act
of
turm
eric
in v
itro
(S
elv
am1
995
), a
nd
co
mp
arab
le w
ith
vit
amin
C
�A
nti
ox
idan
t in
Alz
hei
mer
’s D
isea
se t
o l
ow
er p
laqu
e lo
ad i
n
tran
sgen
ic m
ouse
mo
del
�A
mer
ican
In
stit
ute
for
Can
cer
Res
earc
h s
ays
curc
um
inpre
ven
ts
sto
mac
h c
olo
n, ora
l, e
soph
agea
l, b
reas
t ca
nce
rs…
mo
re r
esea
rch
n
eed
ed r
egar
din
g a
pop
tosi
s
�C
urc
um
inth
oug
ht
to b
e as
eff
ecti
ve
anti
-infl
amm
ato
ry a
s N
SA
IDs
in
trea
tmen
t of
ost
eoar
thri
tis
by s
tim
ula
ting
cort
ico
ster
oid
rel
ease
(B
road
hurs
t199
7,
Am
mo
n199
3)
or
by i
nhib
itin
g l
euk
otr
ienes
and
pro
stag
land
in s
yn
thes
is;
tou
ted
as
CO
X-I
I in
hib
ito
r in
vit
ro
�D
ose
: 300
mg
tid
, st
andar
diz
ed t
o 9
5%
curc
um
ino
ids
per
dose
�S
E:
GI
ulc
er
�D
I: p
oss
ible
add
itiv
e ef
fect
s on
pla
tele
ts (
NS
AID
s, a
spir
in, T
icli
d,
Pla
vix
)
Integrative Medicine
"Stratified Stepped-care Model"
Bio
chem
ical
CA
M
Bio
chem
ical
Ph
arm
acol
ogy
Str
uct
ura
l
(an
ato
mic
)
CA
M
Stru
ctur
al
Su
rger
y
Mo
vem
ent
(fu
nct
ion
al)
Less
Agg
resi
ve
Mo
re
Ag
gre
ssiv
e
Env
iro
nm
ent
Less
Cos
tly
Mo
re
Co
stly
Min
d-B
ody
Less
Ris
ky
Mo
re
Ris
ky
Ene
rgy
Less
Pas
sive
Mo
re
Pas
sive
"Conceptual Template"
(for organizing both diagnostic and therapeutic options)
Comprehensive Collaborative Personalized
Patients Evidence
Risk Stratified Ranked
Com
ple
men
tary
& A
lter
nat
ive
�A
cupunct
ure
�A
lexan
der
Tec
hniq
ue
�A
rom
ather
apy
�A
yurv
edic
�B
iofe
edbac
k
�C
hak
ra
�C
olo
r T
her
apy
�C
ranio
sacr
alT
her
apy
�G
uid
ed I
mag
ery
�H
eali
ng T
ouch
�H
erbolo
gy
�H
om
eopat
hy
�Jo
urn
alin
g
�L
aughte
r T
her
apy
�M
assa
ge
Ther
apy
�M
edit
atio
n
�M
usi
c T
her
apy
�N
aturo
pat
hy/N
utr
itio
n
�P
ilat
es
�R
efle
xo
log
y
�R
eik
i
�R
olf
ing
�S
ham
anis
m
�S
pir
itu
al R
etre
ats
�T
ai C
hi/
Yog
a
�T
radit
ion
al C
hin
ese
Med
icin
e (Q
i)
�W
ater
Th
erap
y
Wh
at i
s th
e P
ract
ice
of
Ho
list
ic P
har
mac
y?
�B
ridgin
g w
ith p
hysi
cian
par
tner
s; f
ocu
s on s
afet
y
�B
uil
din
g p
atie
nt/
phar
mac
ist
par
tner
ship
s –
empow
erm
ent
& a
dvoca
cy i
n h
ealt
hca
re s
yst
em
�M
oti
vat
ional
coac
hin
g (
i.e.
, R
x/O
TC
, die
tary
supple
men
ts, li
fest
yle
, em
oti
onal
, so
cial
, sp
irit
ual
)
�R
efer
rals
to o
ther
cre
dib
le h
oli
stic
pra
ctit
ioner
s
�R
espec
t fo
r div
erse
cult
ure
s &
hea
lthca
re m
odel
s
�w
ww
.rxin
tegra
tives
olu
tions.
com