Welcome to Chicago!

12th Annual Oncofertility Consortium Conference

Bridging the Gaps in Oncofertility Research and Clinical Care: A Global Initiative

November 13-15, 2018 Prentice Women’s Hospital

Chicago, Illinois

2018 Conference Co-Chairs

• Clarisa Gracia, MSCE, MDUniversity of Pennsylvania– Founding Training Member and – Reproductive Endocrinologist and

Fertility Preservation Expert

• Antoinette Anazodo, MD– Pediatric Oncologist and – Global Oncofertility Expert

Thank You Sponsors!The 2018 Oncofertility Conference is funded by the NIH (grants

5R13HD063248 and P50HD076188) and a generous donation from the

Robert H. Lurie Comprehensive Cancer Center of Northwestern University.

Thank you to EMD Serono for their medical education grant and corporate

sponsors Ferring and ReproTech, LTD.

A special thank you to Northwestern University President Morton Shapiro for

his ongoing support of the Oncofertility Conference.

Welcome Advocates!

Welcome International Attendees! Countries Represented at this Year’s Meeting

• USA• Korea• Brazil• Mexico• Japan• United Kingdom• Canada• Australia• Egypt• Nigeria• Thailand• Kenya

Keynote Speakers

Richard Anderson, MD, PhDElsie Inglis Professor of Clinical Reproductive ScienceHead of Section of Obstetrics and Gynaecology, University of Edinburgh

Lillian Meacham, MD Kathleen V. Amos Children’s Chair for Cancer Survivorship; Medical Program Director for the Cancer Survivor Program, Aflac Cancer Center of Children’s Healthcare of Atlanta

This year the Oncofertility Consortium is able to provide AMA PRA Category 1 Credit™ for the Oncofertility Conference.

Learning ObjectivesUpon completion of this activity, participants will be able to:1. Describe the basic science advances in fertility preservation and restoration and global outcomes of pregnancy after cancer2. Identify ethical considerations for fertility preservation in expanded patient populations such as pediatric and gender and sex diverse patients3. Recognize alternative communication strategies for discussion fertility treatment

Accreditation StatementThe Northwestern University Feinberg School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation StatementThe Northwestern University Feinberg School of Medicine designates this live activity for a maximum of 11.25 AMA PRA Category 1 Credit(s)™. Physicians should claim only credit commensurate with the extent of their participation in the activity.

CME TranscriptSee page 4 of your program for instructions on how to obtain your AMA PRA Category 1 Credits™ at the completion of this activity.

Continuing Medical Education

Goals of the meetingWhat you asked for:1. Great speakers! Keep bringing us the world of science and medicine.

2. More time to NETWORK – informal connections rather than fully structured.

3. More time for POSTER DISCUSSIONS.

4. Bring back Kristin and Lisa Campo-Engelstein.5. Please provide time for case studies and reports in small group settings. Our work is hard and it is

great to see how others are struggling with the same problems.

6. Keep the basic science, humanities, education, global and clinical work together in one series.

7. Give us time to Experience Chicago! (Bring your gloves!).

8. Fellows Day is the most important day for our OB/GYN and REI Fellows – Divya and Wendy are rock stars. A great invention!

9. I love the hands on lab series. I love to see what new gadgets Woodruff has in her lab. I hope she lets us mess around with gels and materials again – it is a prism to the way the body works and necessary for our field.

10. Great to have the advocates and patients with us during the meeting.

Agenda

Day 3 Applied Learning Sessions

See page 8 of program for more information and location of each session.

Year in Review: Oncofertility Around the Globe

The Oncofertility ConsortiumAn Infrastructure Partnering Medicine and Science

• 99 US Sites• 200 Sites Globally• 19 Pediatric Sites

The Oncofertility Consortium – a new paradigma global 10+ year NIH-funded interdisciplinary initiative to explore the reproductive future

of cancer survivors

Duncan et al, Reproductive Endocrinology, 8th Edition

§ Medical Oncologists/Hematologists§ Surgical Oncologists/Surgeons§ Radiation Oncologists§ Urologists§ Primary Care Physicians§ Reproductive Endocrinologists/Infertility

Specialists§ Bone Marrow/Stem Cell Transplant Specialists§ Physicians’ Nurses & Staff for the above

specialties § Social Workers§ Mental Health Staff§ Patient Navigators§ Financial Counselors§ Genetic Counselors§ Survivorship Staff§ Cryopreservation Storage Representatives§ Institutional Review Board for Investigational

Procedures

Key Oncofertility HealthcareTeam Members

Oncofertility is growing at a rapid pace

Ataman LM, Ma Y, Duncan FE, Uzzi B, Woodruff TK. Biol Reprod. 2018 Aug 1;99(2):263-265.

Woodruff TK. J Assist Reprod Genet. 2013 Oct;30(10):1249-53

A Global Community of PracticeCreating momentum • Clinical activities

– shared IRBs, shared patient case studies, inclusion of allied health professions

• Research – publications – sharing results, including

failures and successes to avoid hastening work

• Patient Needs – websites, patient decision

tools, and patient navigator

By facilitating these interactions, we ensure that the global oncofertility community is up-to-date on research that can continue to be rapidly translated to the clinic.

Breakthrough discoveries through the OC

2007 Isolated follicles can be grown in vitro

Establishment of a non-invasive index of follicle cryorecovery and growth2010

2012 Aging is associated with chromosome dynamics changes in the human egg

2014The human oocyte contains zinc and its regulatory machinery

Encapsulation supports growth and survival of primordial follicles within the ovarian cortex

2015

2017 Decellularized ovary paper supports follicle survival and growth

Pediatric ovarian tissue contains primordial follicles after treatment

Ovarian tissue can be decellularized

2018 OTC usage in the pediatric population

Mature eggs can be obtained following in vitro follicle growth

Human research repository

Endocrinology of human ovarian follicles grown in vitro

Xu et al, Human Reproduction, 2009; Barrett et al, BOR, 2010; Duncanet al, Aging Cell 2012; Kong et al, MHR, 2014, Laronda et al, JARG,2014; Duncan et al, JAYAO, 2015; Laronda et al, Biomaterials, 2015;Xiao et al, Scientific Reports, 2015; Skory et al, Human Reproducton,2015; Jakus et al, Adv Func Mater, 2017; Armstorng et al, FutureOncolgoy, 2018

Major Accomplishments of the NPC• The National Physicians Cooperative (NPC) is a nationwide network of member institutions

dedicated to preserving the fertility of their patients.

• The NPC has worked in a coordinated and strategic manner enabling better science, education and medical applications to reach men, women and children to preserve their reproductive potential.

• Individual participants at NPC member institutions are the direct points of contacts with patients and many are leaders in translational research.

• The Oncofertilty Consortium (OC) has created an infrastructure for sharing scientific and medical advances in a way that enables patients to access to the most up-to-date medical treatment plans and emerging reproductive technologies.

• Adolescents have a strong desire to participate in their cancer treatment and have significant fertility-related concerns.

• NPC physicians and advanced practice nurses have a high comfort level in discussing fertility issues with patients while further education is needed for providers, especially nurses, to assist with fertility and FP discussions with patients and their families.

• NPC investigators can access rare human reproductive tissue in the Oncofertility Consortium (OC)-NPC Repository for further research to explore and expand the reproductive outcomes of cancer patients and those with fertility-threatening diseases or conditions.

Smith BM, Duncan FE, Ataman LM, et al. Future Oncology. 2018. In press.

Authoritative Oncofertility Resources

Japan Society for Fertility Preservation (JSFP)

Global Impact Is Powerful

Global Engagement• Virtual Grand Rounds from Brazil, Japan, Portugal• Papers in Australia • BOR Commentary• Meetings in Japan, Australia, Peru, China, India, Saudi

Arabia etc. • Reviews from Japan• Portuguese Oncology Recommendations • Survey Studies• Resources in Spanish, Portugese, French, and Turkish• Developing Countries Publication• Regional Oncofertility Networks

Authoritative Oncofertility Resources

Global Connections Are the Foundation of this Field

Visible, Valuable, and Viable

• OPEN• Textbook of Oncofertility• Dialogues in Oncofertility

Oncofertility Professional Engagement Network

OPEN will bridge the gap between domestic and international programs toestablish a strong global network where members share resources,methodologies and experiences. It will build upon the strong framework of theNPC and Global Partners and maintain the valuable subcommittees wherehighly-engaged peers meet (both in person and virtually) to develop new researchprotocols, identify best practices, and discuss challenges and pathways tosuccess.

OPEN Subcommittees

OPEN Member BenefitsInformation on how to establish a multidisciplinary oncofertility programUse of all branding materials that can be tailored to each programAccess to international referral network to patients seeking fertility preservation

Information about the financial aspects of fertility preservationTemplates and assistance for obtaining IRB approval for ovarian or testicular cryopreservation

Access to materials and tools as needed to support research and clinical studies

Invitations to the annual Oncofertility Conference, meetings, and special events

Opportunities to Participate

• Be a local champion of change! – Host a meeting– Participate in Virtual Grand Rounds– Attend annual Oncofertility Conference – Provide updates for quarterly newsletter– Join relevant subcommittees – Develop survey studies for a deeper

understanding of oncofertility at your institution– Publish papers– Translate materials to native language

OPEN: Networking• Calling all nurses!

– Mary Caldwell from OSU• Power in numbers

– New subcommittees – Project ideas– Making critical connectionsà Email us: oncofertility@northwestern.edu

Working together move the field forward at a more rapid pace!

Become a Member

Email oncofertility@northwestern.eduto become a member and join this

exciting partnership!

AT [YOUR INSTITUTION HERE]

reprotopia.northwestern.edu

Textbook of Oncofertility• Early 2019• 35 Chapters• 26 Case Studies • Editors: Teresa K. Woodruff, PhD,

Divya K. Shah, MD, and Wendy Vitek, MD

• THANK YOU FIELD!

Dialogues in OncofertilityAmplifying the Voices of Our Field

Dialogues in Oncofertility is a record of scholarly output generated bymembers of the Oncofertility Professional Engagement Network (OPEN).The goal of Dialogues is to preserve the intellectual works created by theoncofertility community and to promote its authors by enabling discoveryand accessibility of these works by the international scientific community.

à Submit online at oncofertility.northwestern.edu

• All accepted submissions will receive a DOI (Digital Object Identifier)

• Accepted Resource Types:-Abstracts -Articles-Case Reports -Conference Proceedings-Editorials -Guidelines-Lecture Notes -Manuscripts-Presentations -Posters-Projects -Reports-Reviews Complete list of all accepted resource types available online

KEYNOTE SPEAKER – Teresa Woodruff, PhD Vice Chair for Research, Department of Obstetrics Gynecology

Director, The Oncofertility ConsortiumNorthwestern University Feinberg School of Medicine

Co-Chairs Leslie Coker Appiah, MD Director, Fertility Preservation & Reproductive Health Program OSUCCC – James

Leena Nahata, MDDirector, Fertility & Reproductive Health ProgramNationwide Children’s Hospital

Save the Date2019 Oncofertility Conference

Future Hope: Reproductive Health in the Pediatric Population

November 12-14, 2019Chicago, IL

The Future: What we hope

Cancer cells

Germ cells

• No More Cancer– Treatments are changing in real time

• Full Fertility– Interventional options to preserve fertility – Mitigation strategies

• Fully Accessible– Low/no resource environments

• Fully Considered by all Stakeholders– Providers, patients, partners, public

• Eliminate the field

Enjoy the meeting!!