Welcome, Introduction and

Objectives of the Workshop

Prof. Diána Bánáti

Nutrition for the Ageing Brain:

Towards Evidence for an Optimal Diet

3 July 2014

Executive and Scientific Director, ILSI Europe

1

The age distribution of the

population in developed regions

2

Source: UN (2012)

1970 2010

<15

15-59

60+

6 4 2 0 2 4 6 6 4 2 0 2 4 6

Age

of

the

po

pu

lati

on

(ye

ars)

<15

15-59

60+

The age distribution of the

population in developed regions

3

Source: UN (2012)

2010 2050

<15

15-59

60+

6 4 2 0 2 4 6 6 4 2 0 2 4 6

Age

of

the

po

pu

lati

on

(ye

ars)

<15

15-59

60+

x2.5

Source: UN (2013)

Mill

ion

s

500

1000

1500

2000

2500

Least developed countries

Less developed regions, excl least developed countries

More developed regions

Population aged 60 years or over by

development region, 1950-2050

2013 2050

Ageing and dementia

5

Dementia Unhealthy

ageing Healthy ageing

Ageing

Risk factors of healthy ageing

6

Non-modifyable risk factors

• Age

• Family history

• Genetics

Intermediate risk factors

• Cardiovascular disease

• Obesity

• Diabetes

• Pulmonary disease

• Mental illness

Modifyable risk factors

• Unhealthy diet

• Physical inactivity

• Tabacco/alcohol/drugs

• Stress

Growing number of people with

dementia

7

Source: WHO (2012)

High-income

Low- and middle-income

20

40

60

80

100

120

Mill

ion

s

2010 2020 2030 2040 2050

Nutrition and mental performance

What we eat or refrain from eating, may have an important

impact on our cognitive abilities.

Food and nutrients can benefit brain functions. Great

opportunities remain for innovation to optimise

neurodevelopment and reduce risk of cognitive decline.

9

Nutrition and mental performance

Nutrition impacts cognition

Optimisation of neurodevelopment

Prevention of neuro-degeneration and cognitive decline

Subjective effects

Recommendation of WHO for the

future

• WHO recommends:

• Making dementia a national public health and social

care priority worldwide

• Improving public and professional attitudes to, and

understanding of, dementia.

• Improving access to education.

• Neurodevelopment is a little-understood area

with significant long-term implications.

• More research needed to identify modifiable risk

factors.

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Recommendation of WHO for the

future

• WHO recommends:

• Making dementia a national public health and social

care priority worldwide

• Improving public and professional attitudes to, and

understanding of, dementia.

• Improving access to education.

• Neurodevelopment is a little-understood area

with significant long-term implications.

• More research needed to identify modifiable risk

factors.

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PROMOTION of optimal

neurodevelopment and

PREVENTION of neurodegeneration

and cognitive decline are critical

12

ILSI Europe

ILSI Europe is a science-driven organisation

Peer-reviewed publications and

scientific meetings

(workshops, symposia)

Building a bridge between

science and today’s public

health challenges

ILSI Europe’s mission

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SCIENCE-DRIVEN organisation

Addressing COMPLEX scientific issues

Thanks to renowned EXPERTS and scientists

With COMPLEMENTARY experiences

Driven by Science

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• Science-driven approach • Stringent scientific review of our portfolio and new activities by

SAC and BOD

• Scientific outputs • Peer-reviewed articles in high impact factor journals

• Workshops and symposia with best scientists in the fields

• ILSI Europe sessions at key conferences

• At least 50% academics in EGs, SAC and BOD • Close collaboration with key organisations

(e.g. WHO, FAO, EC, national authorities, etc)

• Wide network

•375 publications

•More than 14,000 citations

•h-index 53

Tripartite Approach

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Clinicians

Epidemiologists

Toxicologists

Food Safety

Nutritionists

National

Authorities

EC

Research &

Development

Regulatory

Affairs

Consumer

Science

Public

Health

Applying state-of-the-art science to topics of common

concern, the collaboration between our experts provides

balanced, practical and high quality contributions

to public health science.

A network of highly renowned experts

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• Collaboration with

250 non-industry experts

from 27 countries worldwide

• Active network of

450 scientists

• Communication to

8,700 stakeholders

• Member of the ILSI family

(14 branches and 3 entities)

Additional network of

415 scientists through

the EU-projects we are involved in

ILSI Europe Membership in 2014 62 Members

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Indoor Biotechnologies

Ingredion Incorporated

Institut Mérieux

International Nutrition Company

Johnson & Johnson EAME

Kao Corporation

Kellogg Europe

Kikkoman Foods Europe

Lonza

Luigi Lavazza

Mars

McDonald's Europe

Mead Johnson Nutrition

Merck Consumer Healthcare

Mondelēz International

Monsanto Europe

Nestlé

Newtricious

Nexira

PepsiCo International

Pfizer Consumer Healthcare

Pierre Fabre Dermo

Cosmétique

Premier Foods

Procter & Gamble

Puratos Group

Red Bull

Roquette Group

Royal Friesland Campina

Rudolf Wild

Sanofi-Aventis R&D

Schwabegroup

Sensus

Soremartec Italia – Ferrero Group

Südzucker/BENEO Group

Swiss Quality Testing Services

Syngenta Crop Protection

Tate & Lyle Ingredients

Tereos Syral

Tetra Pak Research

Ülker Bisküvi

Unilever

Yakult Europe

WALA Heilmittel

Abbott Nutrition

Ajinomoto Europe

Arla Foods

Barilla G&R Fratelli

BASF SE

Bayer S.A.S.

Bunge Europe

Campbell Soup Company

Cargill

Chr Hansen

Coca-Cola Europe

Cosucra Groupe Warcoing

Danone

Dow Europe

DSM

DuPont de Nemours

Firmenich

General Mills

Givaudan International

Updated on 05 June 2014

Nutrition and

Mental Performance

Task Force

Objectives of the task force

• To advance and disseminate scientific knowledge on the

effects of diet and food components on mental

performance.

• To increase awareness of the importance of nutrition for

brain function across the lifespan.

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Task Force Members 2014

Dr Siobhan Mitchell ‒ Chair Nestlé CH

Dr Caroline Saunders ‒ Vice-Chair PepsiCo International UK

Prof. Keith Wesnes ‒ Co-Chair Northumbria University UK

Dr Mélanie Charron Soremartec Italia – Ferrero Group IT

Ms Anja Holz Südzucker/BENEO Group DE

Dr Sophie Kergoat Mars US

Dr Hasan Mohajeri DSM CH

Dr Lionel Noah Sanofi-Aventis R&D FR

Dr María Ramírez Abbott Nutrition ES

Dr John Sijben Danone NL

Dr Berenike Stracke Schwabegroup DE

Dr Barbara Winters Campbell Soup Company US

Dr Pratima Rao Jasti ILSI Europe BE

Mr Jeroen Schuermans ILSI Europe BE

Nutrition and Mental Performance

Task Force

• Expert group on ‘Nutrition for the Ageing Brain:

Towards Evidence for an Optimal Diet’

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• Objectives of the expert group:

• no preventative dietary

recommendations

• review the evidence supporting how

nutrients, food and diet influence

brain health

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Peer-reviewed publications

Measuring and Validating the Subjective Effects of Food on Mood and

Mental Performance (to be submitted to Nutrition Research Reviews)

2014

Cognitive Function: Criteria for Validation and Selection of Cognitive

Tests for Investigating the Effects of Foods and Nutrients

2014

Brain Imaging and Human Nutrition: which Measures to Use in

Intervention Studies?

2013

How to Assess Long-term Effects of Nutrition on Brain Function?

(proceedings)

2010

Nutrition and Cognition: Assessing Cognitive Abilities in Children and

Young People

2008

The Influence of Children's Diet on their Cognition and Behavior 2008

Micronutrient Status, Cognition and Behavioral Problems in Childhood 2008

Recent publications

Workshop on

Nutrition for the Ageing Brain

Towards Evidence

for an Optimal Diet

Objectives of the workshop

• Is there evidence of an effect of diet or specific sets

of nutrients or dietary factors on cognitive ageing?

• How to promote healthy cognitive ageing?

• If there is significant evidence, what are the effects of

these nutrients or dietary factors on cognition?

• How do individual and environmental differences or

other dietary components play a role in the effects of

these nutrients?

• Are there age-specific dietary requirements?

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WHO: “Improving public and professional understanding of dementia”

Programme Overview

Session 1: Introduction and Background

Session 2: Mechanisms of Ageing and Neuroprotection via

Nutrients

Session 3: Can a Healthy Brain be Maintained and a Basic

Balanced Diet – What is the Role of Individual

Variation?

Session 4: Methodological Challenges – Finding Solutions

Session 5: Wrap to discuss Specific Nutrient Intake Levels

and Cognitive Ability: Are there Optimal Levels

for Preserving Cognition?

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Expected outcome:

publication in a peer-review journal

Dissemination of the event

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Have a fruitful workshop…

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“It is becoming widely accepted that lifestyle changes are the best protection against dementia, creating a massive

opportunity for nutritional products”… Prof. Keith A. Wesnes - Northumbria University

…and optimal diets!

…and enjoy your stay in Milan!

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The Last Supper, L. da Vinci (1498)

www.ilsi.eu