[ VWV ]

Jointly Provided by: The Department of Emergency Medicine Office of Continuing Medical Education The Brody School of Medicine, East Carolina University The North American Society of Toxinology Eastern Area Health Education Center

Wednesday - Saturday

March 9-12, 2016

Course Content Venom Week 2016 will be an international conference on venomous creatures, their venom, and the medical effects of venom. Attending practitioners and researchers will be provided the most up-to-date information on the animals themselves and on treatments of snakebite, scorpion sting and spider bite. The conference will be held at the East Carolina Heart Institute all day Wednesday through Friday and in the morning on Saturday. The venomous snakes of North Carolina will be on display in the adjacent Warren Life Sciences Building.

Objectives At the end of the conference, the participants will be able to:

Characterize the medically important reptiles and arthropods involved in envenomation

Describe the medical consequences of envenomation

Study and review the principles and practice of antivenom use

Who Should Attend

It is anticipated that approximately 250 professionals in the fields of emergency medicine, medical toxicology, veterinary medicine, nursing, pharmacy, arachnology, antivenom manufacturing, and captive collections management will attend the 4 day-long conference.

Hotel Information Holiday Inn 203 SW Greenville Blvd Greenville, NC 27834 (252-355-8300) 3.7 miles to ECHI $99 plus tax. March 8-12, 2016.The breakfast buffet will be included. Guests will need to make reservations at least 30 days prior. The cutoff for this fee is February 8th 2016. Any room booked after this date, may be subject to a higher rate. Holiday Inn Express 900 Moye Blvd. Greenville, NC (252-754-8300) 1.0 mile to ECHI $99 plus tax. March 8-12, 2016. Guests will need to make reservations at least 30 days prior. The cutoff for this fee is February 8, 2016. Any room booked after this date, may be subject to a higher rate. Candlewood Suites 1055 Waterford Commons Drive, Greenville, NC (252-317-3000) 1.5 miles to ECHI Courtyard by Marriott 2225 Stantonsburg Road Greenville, NC (252-329-2900) .5 miles to ECHI Residence Inn Marriott 1820 West 5th Street Greenville, NC 27834 (252-364-8999) .6 miles to ECHI Microtel Inn & Suites by Wyndham 450 Moye Blvd, Greenville, NC 27834 (252-758-7282) .6 miles to ECHI

All proceedings will be informal. Please plan to dress casually and bring a sweater or jacket for your

comfort.

Credit Information

ACCREDITATION: This activity has been planned and implemented in accordance

with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the Department of Emergency Medicine, Office of Continuing Medical Education of The Brody School of Medicine, East Carolina University and The North American Society of Toxinology in association with Eastern Area Health Education. The Brody School of Medicine of East Carolina University is accredited by the ACCME to provide continuing medical education for physicians.

CREDIT: The Brody School of Medicine of East Carolina University designates this live

activity for a maximum of 24.5 AMA PRA Category 1 Credits™. Physicians should claim only the credits commensurate with the extent of their participation in the activity.

Veterinarian Continuing Education Credit

All presentations conducted during Venom Week Symposium have been submitted to North Carolina Veterinary Medical Board for CE credit approval. Continuing education credit is based on one hour (60 minutes = 1 contact hour) of total lecture hours attended. The North Carolina Veterinary Medical Board does not approve attendance to exhibit halls or breaks. The final number of Contact Hours approved for Veterinarians is pending upon presentation reviews by the North Carolina Veterinary Medical Board.

Emergency Medical Technicians Credit is pending

EAHEC Contact Hours:

Certificates reflecting 24.5 contact hours of education will be awarded at the completion of the program.

VENOM WEEK V AGENDA Wednesday, March 9, 2016 7:30 REGISTRATION/BREAKFAST Buffet 8:00 WELCOME/OVERVIEW: Sean P. Bush, MD 8:10 Keynote: The Dynamics and Kinetics of the Venom-Antivenom Dance Steven A. Seifert, MD 9:00 Keynote: Recovery from Pit Viper Envenomation: Answers and Questions Eric Lavonas, MD 9:50 BREAK 10:10 Keynote: Antivenom Use in Copperhead Envenomation Charles J. Gerardo, MD 11:00 Comparison of F(ab’)2 versus Fab Antivenom for Pit Viper Envenomation: A prospective, Blinded,

Multicenter, Randomized Cinical Trial Sean P. Bush, MD 11:30 Continuous Intravenous Infusion Gus A. Gross, MD 12:00 LUNCH

1:00 Neutralization of Crotamine Isoforms with a Chemically-Modified DNA Aptamer: Development of a

Synthetic Antivenom Elda E. Sanchez, PhD 1:50 Factors that Influence the Clinical Severity of Venomous Snakebites in Southern California Aaron Corbit, PhD 2:20 A Rare Chinese Pit Viper in Minnesota: Protobothrops mangshanensis Envenomation Daniel Keyler, PharmD 2:45 BREAK 3:00 Late Coagulopathy After F(ab')2 Treatment of Rattlesnake Envenomations in Southern California." Sean P. Bush, MD 3:20 A Gila in the Heartlands Steven A. Seifert, MD 3:40 Coral Encounter Gus A. Gross, MD 4:00 Pain Control with Fentanyl Patch Gus A. Gross, MD 4:20 A Lethal Lapse. Envenomations and Ebola. Critical Gaps in Aid Worker Preparation Sean G. Smith, BSN, RN, BBA 4:40 Keynote: Biodiscovery Potential of Understudied Venomous Reptile Lineages Bryan G. Fry, PhD 5:00 ADJOURN

VENOM WEEK V AGENDA Thursday, March 10, 2016 7:30 REGISTRATION/BREAKFAST BUFFET 8:00 WELCOME/OVERVIEW: Sean P. Bush, MD 8:10 Keynote: Surgical Management Considerations of Venomous Snakebite Eric Toschlog, MD 9:00 Keynote: “Do Antivenoms Work? Barriers to Proving Efficacy in Antivenom Trials” Richard C. Dart, MD, PhD 9:50 BREAK 10:10 Apparent Efficacy of Low-Dose Constant-Infusion Crotalidae Antivenom for Control of

Defibrinogenation Recurrence Syndrome Following Envenomation by the Eastern Diamondback Rattlesnake (Crotalus adamanteus)

Craig Kitchens, MD 10:35 A Polyspecific Antivenom for Sri Lanka: First to Include Hypnale Daniel Keyler, PharmD 11:00 The Efficacy of Early Fab Antivenom vs. Placebo Plus Optional Rescue Therapy on Recovery from

Copperhead Snake Envenomation Eric Lavonas, MD 12:00 LUNCH -- Native Snake Display—Sean P. Bush, MD and Dorcas O’Rourke, DVM 1:00 Keynote: Re-Testing the ‘Testing’ of the Toxicofera: The Importance of Proper Phylogenetic

Methods in Toxinology Bryan Fry, PhD 1:50 The Antivenom Index: An Online, Systematic Response to Non-Native Envenomations in the US Steven A. Seifert, MD

2:20 Paradoxal Exception to Island Tameness: Increased Defensiveness in Insular Population of Rattlesnakes William K. Hayes, PhD 2:45 BREAK 3:00 Diet and Venom Ontogeny in Insular and High-Altitude Populations of the Southern Pacific Rattlesnake

(Crotalus oreganus helleri) William K. Hayes, PhD 3:15 1. Medically Relevant Venomous Snakes in Nepal 2. Attitudes, Knowledge and Awareness of Snakes and Snakebite Care and Prevention among Chitwan

National Park Buffer Zone Inhabitants: Implications for Conservation and Public Health in Southern Nepal 3. Eco-epidemiological Circumstances and Pre-admission Histories of Proven Krait and Russell's Viper

Bites Including Hospital-based Snakebite Incidence in Southern Nepal Deb Pandy, PhD 4:00 Snakebite Incidence in Western Development Region, Nepal Kamal Devkota

4:20 Bothropstoxin-I (BTHTX-I) And Polylysine Can Potentiate Bothropstoxin-ii (BTHTX ii) Activity and They

are Antagonized by Fusosylated Chondroitin Sulfate Paulo Melo, MD, PhD 4:40 Northern Pacific Rattlesnake (Crotalus oreganus) Envenomation Leads to Ocular Destruction and

Coagulopathy Mike Touger, MD

5:00 ADJOURN

VENOM WEEK V AGENDA Friday, March 11, 2016

7:30 REGISTRATION/BREAKFAST BUFFET

8:00 WELCOME/OVERVIEW Sean P. Bush, MD

8:10 Keynote: Widows and Recluses and Hobos, Oh My: a Walk through the Past and Present of North American Spider Envenomation

Richard S. Vetter, MS

9:00 Ontogeny of Defensive Behaviors in the Western Black Widow Spider (Latrodectus hesperus) David Nelson, PhD

9:25 Characterization of the Proteome for the Wandering Spider, Ctenus hibernalis (Aranea:Ctenidae)

Jeff Cole

9:50 BREAK

10:10 Sensory Shifts Following Autotomy in the Golden Orb Weaver (Nephila Clavipes): Leg Arrangement and Vibratory Signals David Nelson, PhD

10:30 Venoms from Centruroides sp. Scorpions Cleave SNARE Proteins Paul L. Fletcher, Jr., PhD

10:50 Metalloproteases in New World Scorpion Venoms Cleave Intracellular Membrane Fusion SNARE Proteins VAMP2 and VAMP8 Paul L. Fletcher, Jr., PhD

11:10 Phospholipase D Toxins from Spiders, Bacteria and Fungi Generate Cyclic Phosphate Products Daniel M. Lajoie

11:40 Antagonism of In-Vitro and In-Vivo Activities of Apis mellifera Venom by Antiapilic Serum Paulo Melo, MD, PhD

12:00 LUNCH – “The Venom Interviews—Professions and Professionals in Venomous Herpetology” (Video) Ray Morgan

1:00 Keynote: History, Controversies, and What is New in Treating Rattlesnake Envenomations in Animals Karen Seibold, DVM, DACVECC/ Reagan Wells, DVM, MS, DACVECC 1:50 Review: The Dog as a Translational Model for Envenomation Craig Woods, DVM

2:10 In Vitro Echinocytosis Development Secondary to Rattlesnake (Crotalus atrox) and Copperhead (Agkistrodon Contortrix laticinctus) Venom in the Dog and the Horse

Stasia Sullivan

2:30 Severe Pit Viper Envenomation with Extended Clinical Signs and Treatment Complications Michael Schaer, DVM, DACVIM, DACVECC

2:50 BREAK

3:00 Efficacy of an Equine Hyperimmune Plasma Product against the Venom of Four North American Rattlesnakes

Lyndi L. Gilliam

3:30 Prospective Evaluation of the Incidence of Wound Infection in Rattlesnake Envenomation in Dogs Jennifer Schultz, DVM and Amy Carr, DAVECC

4:00 Rattlesnake Envenomation in Three Dairy Goats: Application of an Existing Equine Rattlesnake Bite Severity Scoring System

Joe Smith, DVM, MPS

4:30 Coagulopathy in Prairie Rattlesnake (Crotalus viridis) Envenomation: with Carbon Monoxide Releasing Molecule - 2 Increases Clot Strength and Attenuates Fibrinolysis Tyler Johnson, DO

4:45 Q&A

5:00 ADJOURN

Venom Week V Agenda Saturday, March 12, 2016 7:30 REGISTRATION/BREAKFAST BUFFET 8:00 WELCOME/OVERVIEW Sean P. Bush, MD 8:10 Humanized Cobra Venom Factor: Development of a Therapeutic Agent from a Venom Component Carl-Wilhelm Vogel, MD, PhD 8:35 Detection of Venom-Antivenom Complex Formation using Size-Exclusion Chromatography: Factors

Effecting Elution Profiles and Immune Complex Formation Charles G. Sanny, PhD 9:00 Taking Up Serpents: Religious Snake Handling in the United States Kristen Wiley 9:25 Conservation of a Venomous Island Endemic through Skillset Development Kristen Wiley 9:50 BREAK 10:10 Community Engagement in a Snake Antivenom Development Project, Aligning past and Present, Putting Aside Ethnocentrism and Embracing Cultural Diversity for Success Kimberly McWhorter, MPH, CPH 10:25 Rattlesnake Canyon, Building the World’s Largest Indoor Rattlesnake Exhibit Jessi Krebs 10:40 Florida Antivenin Bank to Miami Dade Venom Response Bureau: The History of a Unique Anti-Venom

Bank and Venom Response Team. First Reported Case of Deinagkistrodon acutus Envenomation in United States; A Case Report of Venom Unit Interstate Response and Care

Benjamin Abo, DO, EMT-P FAWM(c) 11:10 Sistrurus miliarius Envenomation Report Ali Lyoob 11:25 Evaluating First-Aid Responses to Cnidarian Stings: A Critical Review of the Literature and a Novel Assay

Array to Standardize Testing Christie Wilcox 11:40 The Paracelsus Paradox: Therapeutic Toxinology…”Dosis Facit Venenum!” Sean G. Smith, BSN, RN, BBA 11:55 Looking Forward… the Next Venom Week Daniel Keyler, PharmD and Sean P. Bush, MD 12:15 ADJOURN

PROGRAM DIRECTOR

Sean P. Bush, M.D., F.A.C.E.P. Professor of Emergency Medicine, with Tenure Department of Emergency Medicine Brody School of Medicine

GUEST FACULTY

Richard C. Dart, MD, PhD Professor Emergency Medicine University of Colorado School of Medicine Director Rocky Mountain Poison & Drug Center Denver Health and Hospital Authority Charles J. Gerardo, MD, MHS, FACEP Associate Professor Vice Chief of Operations Division of Emergency Medicine Duke University School of Medicine Bryan Grieg Fry, PhD Venom Evolution Lab, School of Biological Sciences University of Queensland Eric Lavonas, MD, FACEP, FACMT, FAACT Associate Professor Emergency Medicine, University of Colorado Director Emergency Medicine Program Expansion and Outreach Denver Health and Hospital Authority

Karen Seibold, DVM, DACVECC Owner/Operator Animal Urgent Care, 24 Hour Emergency Hospital for Animals North San Diego County Steven A. Seifert, MD, FAACT, FACMT Professor University of New Mexico, School of Medicine Medical Director New Mexico Poison and Drug Information Center Richard S. Vetter, MS Research Associate (Retired) Department of Entomology University of California Riverside, California Raegan Wells, DVM, MS, DACVECC Emergency Animal Clinic BluePearl Veterinary Partners Medical Director Emergency & Critical Care Veterinarian Phoenix, Arizona

BRODY SCHOOL OF MEDICINE FACULTY

Eric Toschlog, MD, FACS, FCCM Associate Professor Department of Surgery Chief, Trauma and SCC Director Surgical Critical Care and Surgical Critical Care Fellowship

REGISTRATION Pre-registration is required. Advance payment of fee is necessary to guarantee space. For your

convenience, an e-syllabus which you can print from your computer is available at no extra

charge. Payment may be made by check or by credit card (VISA, MasterCard, Discover and

American Express). Registrations may be completed on-line at

http://www.ecu.edu/cme/venomweek2016.cfm or faxed to 252.744.5229. Checks should be

made payable to Office of CME. For information on other continuing medical education programs,

please visit us at www.ecu.edu/cme.

IMPORTANT INFORMATION... PLEASE READ CAREFULLY BEFORE REGISTERING!!!

A letter of confirmation which includes a link to the e-syllabus and maps will be emailed prior

to the program date. Please be sure that we have a current email address for you upon

registration so that you will receive all follow-up course information. We will not be mailing any

correspondence. The registration fee provides for participation in the proceedings, breakfasts,

lunches, refreshment breaks, and a substantial course e-syllabus.

REGISTRATION FEES

Early Registration: $450.00 MD/DO/PharmD/VD/All Doctorates

(Until December 1, 2015) $350.00 RN/PA/NP/ Other Healthcare Professionals

$250.00 Students/Non-degree and non-healthcare professionals

NAST Members $425.00 MD/DO/PharmD/VD/All Doctorates

(Until December 1, 2015) $325.00 RN/PA/NP/ Other Healthcare Professionals

$225.00 Students/Non-degree and non-healthcare professionals

Registration: $500.00 MD/DO/PharmD/VD/All Doctorates

(After December 1, 2015) $400.00 RN/PA/NP/ Other Healthcare Professionals

$300.00 Students/Non-degree and non-healthcare professionals

NAST Members $475.00 MD/DO/PharmD/VD/All Doctorates

(After December 1, 2015) $375.00 RN/PA/NP/ Other Healthcare Professionals

$275.00 Students/Non-degree and non-healthcare professionals

CANCELLATIONS: All fees will be refunded if notification is received by the Office of CME on or

before February 26, 2016. Those received after February 26th will be subject to a $35.00

reduction for administrative commitments. NO REFUNDS will be made for cancellations received

after March 4, 2016.

Any individual requiring accommodation under ADA or for general information and registration assistance, please call the Office of CME (252) 744-5208.

Venom Week – March 9-12, 2016

Return to: Office of CME, PO Box 7224, Greenville, NC 27835-7224, ATTN: Registration

Phone: (252) 744-5208 FAX (252) 744-5229

All participants should pre-register

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Please check the credit(s) you wish to receive, if available.

AMA, PRA Category 1 Credit(s)™ Contact Hours Veterinarian Continuing Education Credit

Emergency Medical Technicians Credit

FEES Early Registration NAST Member Registration NAST Member Early Registration After 12/1/15 After 12/1/15

MD/DO/PharmD/VD __$450.00 __$425.00 __$500.00 __$475.00 Other Doctorates RN/PA/NP/ __$350.00 __$325.00 __$400.00 __$375.00 Other Healthcare Professionals Students/Non-degree __$250.00 __$225.00 __$300.00 __$275.00 and Non-healthcare Professionals

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