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WECANTM

Weigh Evidence inCancer, Aging, & Nutrition

Mark Hunter, M.D.Director

Division of Gynecologic Oncology

Thank You!

Who Am I?

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Who Am I?

Who Am I?

Who Am I?

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Who Am I?

What’s your Self Medication

Breads Bibles

Bottles Buys

Butts Body

Bets Booty

Boxes Brawls

Your Brain and It’s Busy Bees

Building Bubbles

Babies Beats

Bass Books

Bucks Bonding

Bikes Beans

Botany Breathing

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Relative B Time

0

5

10

15

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25

30

35

40

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Time

Relative B Time

0

10

20

30

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Excess

250 lbs = 120k grams = 1 million kcalories = 1,000 days of storage = 48,000 gallons of gas!

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“Your Tank is on Empty”

Dependence/Habit

Dependence Blunts

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Obesity Worldwide

0

200,000,000

400,000,000

600,000,000

800,000,000

1,000,000,000

1,200,000,000

1,400,000,000

1,600,000,000

1,800,000,000

2,000,000,000

2008 2014

500 Million Obese in 2008

1.9 Billion Obese in 2014

Elevated Risk of Cancer Death with Excess Energy Storage

0% 100% 200% 300% 400% 500% 600% 700%

Prostate cancerBrain cancer*

Ovarian cancerBladder Cancer*

LeukemiaMultiple MyelomaColorectal cancer

Melanoma*Bile duct cancer*

Stomach cancerLymphoma

Larynx cancer*Gallbladder cancer

Breast cancerEsophageal cancerPancreatic cancer

Small Intestine cancer*Cervical cancer

Liver cancerKidney cancerUterine cancer

34%50%51%63%70%71%84%87%90%94%95%

210%213%

252%275%276%280%

320%450%

475%620%

Elevated Risk of Death

Cautious Optimism

0

50000

100000

150000

200000

250000

300000

1880

1900

1905

1910

1915

1920

1925

1930

1935

1940

1945

1950

1955

1960

1965

1970

1975

1980

1985

1990

1995

2000

2005

2010

count

• An exponential explosion in cancer knowledge and publications

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The Coming Cure

Pizza

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Longer LifeLess DiseaseLess Suffering

Eat MoreDrink MoreExercise Less

Cancer cells called “glucose addicted”

Calorie restriction slows aging

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High plant fats, low carbohydrates Bigelovin showed more significant tumor suppression and less side

effects than conventional FOLFOX (PMID: 28300756)

Sunflower Lectin has anti-neuroblastoma properties

(PMID: 28075401)

Calorie restriction slows tumor growth

Fewer calories,Less tumor growth

Standard Diet

Calorie Restricted

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High fat, low carbohydrate diets

High fat, low Carbohydrate dietsImprove survival

Standard Diet

Carb Restricted

Tumor weight, Tumor volumeBoth reduced with

high-fat, low-carb diets

PMID 25502434

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Total Calorie Restriction

PMID 25502434

High Fat, Low Carbohydrates

PMID 25502434

PMID 25502434

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Guidelines1: Know your BMI

2: Eat slowly, with a fork and knife. Consume fewer calories

3: To lose weight, keep your carbohydrates below 40 grams per day. Perform intermittent fasts.

4: Avoid the 7 starchy snags (Bread, Rice, Noodles, Flour, Corn, Potatoes, Sugar).

5: The rest of your food, by weight, should be 70% unsaturated fat (preferably from plants) and 20% protein.

6: Treat yourself to new or slightly worn clothes every 5-10 lbs or so.

7: Help and encourage others. There is strength in numbers.

8: Help your pet. They deserve to live longer too.

9: Drink no liquid that has a single calorie.

10: Mind your prebiotics. Sugar-free Metamucil can change your life.

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Celery protects against breast cancer (PMID: 28212313)

Oleanolic acid in olive oil is active against multiple cancer pathways

(PMID: 28300756)

Nisin in cheese exhibits selective cytotoxicity towards cancer cells

(PMID: 26678028)

Asparagus polysaccharide exhibited significant anticancer activity against

hepatocellular carcinoma (PMID: 24310501)

onionin A directly inhibited ovarian cancer cell proliferation

(PMID: 27404320)

Capsaicin in paprika targets multiple signaling pathways, oncogenes and tumor-suppressor genes

in various types of cancer models (PMID: 26976969)

Beverages

• Calorie Containing• Soup

• Medicine

• Alcohol

• Zero Calorie• Water• Coffee

• Tea

• Diet Soda

• Unsweetened Almond Milk

Coffee• Coffee also improves• Neurologic function• Aging• Liver disease• Parkinson’s• Prostate cancer risk• Many other cancers

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Tea

• Phenols in tea have been shown to have activity against multiple pathways in multiple cancers

• Coffee and Tea have been shown to decrease the risk of brain tumors (PMID 27560973)

Snacking

• Snacking is dangerous

• Cooking• Cleaning• Bored• Depressed• Happy• Want Cookie!

Consider your snacks your meals, and your meals your snacks

• Nuts• Jerky• Seeds• Cherry Tomatoes• Olives• Cheese• Avocados• Boiled eggs• Canned fish• Unsmoked deli meat• Sugar free yogurt• Celery• Peanut Butter

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Apigenin in bell pepper reduced the risk of breast cancer, hepatocellular carcinoma

and glioblastoma (PMID: 28378188)

B6 in bell peppers reduced the risk of all cancers in a metaanalysis (PMID: 28376200)

Spice It Up

Muy Caliente!

• Turmeric• Paprika• White, Black and Red Pepper• Garlic• Onion• Oregano & Thyme• Rosemary, Ginger, & Sage• Cinnamon

Fruit

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FruitThe right fruits are very helpful. Remember, they contain carbs so keep track.

• Blueberries

• Anti-inflammatory• Increases immunity• Slows migration of cancer

cells

• Blackberries• Raspberries• Strawberries

Dessert: a scoop of chunky peanut butter, sprinkled with blueberries, chopped walnuts, and >75% cacao dark chocolate. Deliciously enjoyed with a fork.

Wine

Keepin it Green

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Warning: Beware of Carbohydrate Utensils

• Buns• Chips• Tortillas• Taco shells• Crackers• Rice cakes• Bread of any kind• Potato/Fry• Pizza crust• Noodles

Use a fork or spoon instead

Isothiocyanates in cabbage display anti-carcinogenic activity by reducing the

activation of carcinogens (PMID: 27880994)

Avocado defensin inducing intrinsic apoptosis in breast cancer

cells (PMID: 27470405)

Lycopene Extracts from Tomato Products Induce Apoptosis in Cultured Human Primary Prostate

Cancer Cells (PMID: 28345329)

The SneakyRecipes calling for flour, bread crumbs, rice, pasta, or potatoes, are just as good when you omit the flour, bread crumbs, rice, pasta, and potatoes.

• Cassaroles• These dishes are impressive

without the flour, hash browns, rice, or noodles.

• Soups• Skip the noodles, potatoes, rice,

and flour. Meat, cheese, and vegetables are outstanding.

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Secret Weapons for Success (GetMESSYTM)

M E S S YMindfulness Eating Socializing Sex YogaMeditation Exercise Schooling SleepMusicMedication

Mindfulness• Get comfortable with discomfort

• Give your full attention to the sensation of hunger

• Embrace the feeling of hunger instead of distracting yourself from it.

• By delving into this sensation, you are able to remind yourself that this discomfort will pass, much like an uncomfortable hot or cold, or other emotions that you have experienced.

• This will make your discomfort become distant, no longer unbearable or endless.

• Remember, the discomfort of hunger is most likely withdrawal.

• Hunger is not your body dying. Hunger is your body lying.

Meditation

• Improved mood, sexual-related distress, and sexual function in women with gyncancers (PMID 27592509)

• Improvement in cognitive impairment, fatigue, quality of life, and sleep in breast cancer patients using neurofeedback. (PMID 23584550)

• Improvements in fatigue, stress, anxiety, confusion, quality of life, spirituality, and posttraumatic growth with breast cancer recovery program (PMID 27193737)

• Improved fatigue, anxiety, depression, sleep, and pain symptoms for breast and colorectal cancer patients. (PMID 27189614)

• Meditation and music reduced pain and anxiety during core biopsies (PMID 26853501)

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Exercise in Treatment and Recovery Improves:

• Cancer specific concerns• Body image• Self esteem• Emotional well-being• Sexuality• Sleep disturbance• Social functioning• Anxiety• Fagitue• Pain symptoms• Quality of life

• (PMID 22895961)

Socialize

Yoga• Sleep disturbance, anxiety, and quality of life was improved with yoga for patients

undergoing chemotherapy. (PMID 22525009)

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Thank you.• Special thanks to:

• Emily Patterson

• Delores Lipscomb

• Carrie Doss

• Lisa, Laci

• All of our amazing nurses and team members

• Patients and Family

Knowledge is Power…• PUBMED.GOV

• WeighTheEvidence.org

Thank You!