webinar logistics - cello health bioconsulting

•  Webinar Logistics

•  Co-Sponsor Acknowledgements

•  Introduction of Our Moderator, Linda Pullan, PhD

•  Introduction of Our Panelists

•  Snapshot of Topics for Discussion

•  Panelist Discussion

•  Responding to Audience Q&A

•  Thank you and Wrap-up

AGENDA

•  The web panel discussion will run from 8-9:30a PT / 11-12:30p ET.

•  Contribute questions via the Questions box in the GoToWebinar control panel.

•  We will address questions intermittently or at the end. If we don’t get to your question, we will forward them to the panel for a direct response.

•  The web panel discussion is being recorded and we will notify you via email when it becomes available.

•  Copies of the slides will also be made available to all registrants.

•  We welcome your feedback after the web panel so we can improve others in the future!

LOGISTICS

•  World's largest trade association of biotechnology companies, academic institutions, state biotechnology centers and related organizations across the US and in more than 30 other nations

BIO CEO & Investor Conference

•  Takes place, February 12-13, 2018 in New York

•  International biotech investor conference focuses on early and established private companies as well as emerging public companies

•  Poised for another record-breaking year of one-on-one partnering meetings

•  Visit bio.org/ceo to register and for more details

BIOTECHNOLOGY INNOVATION ORGANIZATION

•  Founded over 25 years ago, Defined Health, a CELLO HEALTH business, is a leading biopharmaceutical business development strategy consulting firm whose clients include a mix of pharma, biotech and specialty pharmaceutical companies

•  Defined Health's consultants hold advanced degrees in science, medicine and business, and have industry experience in business development, commercial evaluation, finance, licensing, drug discovery and R&D

Cancer Progress by Defined Health

•  Takes place, May 8-9, 2018 in New York

•  The 29th Annual Cancer Progress Conference – “The Premier Cancer Conference for Industry Leaders”

•  Visit cancerprogessbydh.com to register and for more details

DEFINED HEALTH

•  Provides Life Sciences organizations the confidence to simply and securely share confidential documents with third parties

•  Is the ONLY solution of this kind with biopharma-specific features

•  Commonly used for Licensing / Partnering, Asset sales, Fundraising

and

•  For communicating with Scientific Advisory Boards, Board of Directors, CROs/CMOs, regulatory advisors, consultants and other external parties

•  For protecting documents subject to sponsor and regulatory agency audits

•  As a secure corporate repository

As a recognized leader in life sciences, the Biotechnology Innovation Organization and 49 national and regional Life Sciences Associations have chosen ShareVault as their preferred virtual data room provider.

SHAREVAULT

OUR MODERATOR

Linda M. Pullan, PhD Pullan Consulting

•  Over 20 years of industry experience, now a well-known partnering consultant for her firm, Pullan Consulting

•  Extensive knowledge and experience in licensing and business development from Amgen, AstraZeneca, Kosan and many others

•  Began in drug discovery, led teams that put Seroquel, a multi-billion dollar antipsychotic, along with other molecules into development

OUR PANELISTS

Sanket Argawal, MBA Executive Director,

Global Oncology, Amgen

Jeff Bockman, PhD SVP, Head of Oncology

Practice, Defined Health

Ezio Bonvini, MD SVP, Research and CSO, MacroGenics

Chris Hurff, MBA Sr Director, Business

Development, Takeda

Taylor Schreiber, PhD CSO, Shattuck Labs

Ali Tehrani, PhD President & CEO,

Zymeworks

Panelist Discussion

DEFINITIONOFBISPECIFICS,

MULTI-TARGETING

SNAPSHOT OF TOPICS

CATEGORIESOFTARGETSTHATBENEFITFROMMULTI-TARGETING

FORMATSOFBISPECIFICS

INDICATIONSCHALLENGESOFMAKINGBISPECIFICS

DEALS

COMPETITIONWITHBISPECIFICS

DATANEEDEDFORPARTNERSHIPS BUILDINGVALUE

Sanket Argawal Amgen

Jeff Bockman Defined Health

Ezio Bonvini MacroGenics

Chris Hurff Takeda

Taylor Schreiber Shattuck Labs

Ali Tehrani Zymeworks

DEFINITION OF BISPECIFICS, MULTI-TARGETING

Multivalent Biologics: Immune Cell-

Mul;valentBiologics

BispecificsNon-An;body(e.g.,MolecularPartners’Pieris)

BispecificsAn;body-Based

ImmuneCellEngagers

T-cellEngagers(CD3)

(e.g.,Amgen/MicrometBiTEs,Macrogenics’

DARTs))

NKCellEngagers(CD16)

CIT—CIT(e.g.,dualcheckpoint

inhibitors,Xencororf-star)

CPI-CPI CPI-Cos;m Other

Non-CIT—Non-CIT(e.g.,Macrogenics,Janssen,Roche)

Source: Defined Health §  CIT=Cancer Immunotherapy MOA; CPI=Checkpoint Inhibitors; Costim=Costimulatory Agonists;