UHN REF # 2016-0698

University Health Network

Software Access and Data Hosting License Agreement

This Software Access and Data HostingLicense Agreement (“Agreement”) is entered into effective as of the 13th day of June, 2017 (“Effective Date”) by and between:

(1) University Health Network, an Ontario not-for-profit corporation incorporated under the University Health Network Act, 1997, with a business office at 101 College Street - Suite 150, Toronto, Ontario, M5G 1L7 (“UHN”); and

(2) International Retinoblastoma Consortium (IRbC), a non-profit corporation having its primary offices at 11 Rose Ave, Toronto, Ontario M4X 1N6 (“Licensee” ).

UHN and Licensee may be individually referred to as a “Party” and together as the “Parties”.

WHEREAS, in the field of retinoal blastoma, Care Providers (as defined below)health care providers wish to have better access to their patients’ medical records and researchers wish to have better access to medical data,

WHEREAS UHN has developed certain software which is useful for storing, retrieving, accessing, visualizing, and viewing health data stored on a secure “cloud” server (such as the Telus Health cloud) as further described in Schedule A attached to this Agreement (the “UHN Software” as further defined below),

WHEREAS Licensee wishes to use the UHN Software for the purposes of: (1) has formed a network of universities, hospitals and research institutions who treat or researchproviding health care providers in the area of retinal blastoma retinoblastoma worldwide to have access over a secure internet portal to the database platform supported by the UHN Software in order to contribute and access patient data for clinical use; (2) permitting Licensee, together with its authorized principal investigators and subsites, to access de-identified data to be used for research purposes; (3) providing patients, family members, guardians and their authorized legal representatives to have access to their own patient data; and (4) to contract with vendors (such as Telus and MedChart) to provide hosting services and online portal software.and will enter into a data bank agreement with the Licensee (the “Members”) which agreement shall pertain to the establishment and maintenance of the IRbC retinal blastoma retinoblastoma database to be hosted at UHN for which the Licensed UHN Software shall be utilized (the “Data Bank Agreement”),

WHEREAS Licensee wishes to allow the MembersAuthorized Users (as defined below) to access the UHN Software for the Limited Purpose (as defined below), and

WHEREAS UHN is willing to license the right to Licensee to allow for use of the UHN Software on the terms provided herein, and is further willing to provide installation and service support for the UHN Software pursuant to a separate Service Agreement (as defined herein) entered into concurrently with this Agreement and attached hereto as Schedule C;

UHN REF # 2016-0698

NOW THEREFORE in consideration of the mutual covenants made in this Agreement, and other good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the parties agree as follows.

1. Interpretation.

(a) Definitions . For purposes of this Agreement, unless otherwise stated in the text of this Agreement, the following definitions shall govern.

“Agreement” shall have the meaning given to it in the preamble to this Agreement.

“Applicable Laws” shall mean all applicable laws, statutes, regulations, treaties, judgments and decrees and (whether or not having the force of law) all applicable official directives, rules, consents, approvals, by-laws, permits, authorizations, guidelines, orders and policies of any governmental or regulatory body having authority, including all applicable privacy laws and laws governing the protection of personal information or personal health information.

“Authorized User” shall mean end users of the Licensed UHN Software that are Site Leads, Site Members, and Non-Site Members.

“Business Day” shall mean any day except Saturday, Sunday or a day that is a civic or statutory holiday in the city of Toronto, Ontario.

“Care Provider” shall mean a patient’s relative, guardian, doctor, nurse, or other person who is part of the patient’s circle of care.

“Confidential Information” shall mean information that is designated as confidential or proprietary by the Discloser at the time of disclosure and that is any non-public information of a party, in oral, written, graphic or machine-readable form, research, product plans, products, inventions, processes, designs, algorithms, source code, programs, business plans, agreements with third parties, services, customers, marketing or finances; provided that the existence of this Agreement between the parties is not considered Confidential Information. For the avoidance of doubt, the Documentation is UHN’s Confidential Information.

“Data” shall have the meaning as set out in Section 6(b).

“Data Bank Agreement” shall have the meaning given to it in the preamble to this Agreement.

“Discloser” shall mean a party disclosing Confidential Information to the other party under this Agreement and pursuant to and subject to the provisions of Section 8 (Confidentiality) of this Agreement.

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“Documentation” shall mean any manuals, product descriptions, product specification sheets, and other written materials that relate to the UHN Software provided by UHN to Licensee under this Agreement.

“Effective Date” shall have the meaning given to it in the preamble to this Agreement.

“Fees” shall mean the one time Software License Fee (as defined herein), and the Initial Fee and the Annual Service Fee (each as defined in the Service Agreement).

“Field” means retinoblastoma. -

“Intellectual Property Rights” shall mean all worldwide intellectual property rights, including, but not limited to, patents, copyrights, rights in databases, authors’ rights, trademarks, trade names, know-how, and trade secrets, whether registrable or otherwise, including any rights in applications and rights to make applications in respect thereof (where applicable), and all other intellectual property rights of a similar or corresponding character that may now or in the future subsist irrespective of whether any such rights arise under Canadian, foreign, or international intellectual property, unfair competition, or trade secret laws.

“Licensed UHN Software” shall mean the UHN Software, Updates, and related Documentation.

“Licensed User” shall mean end users of the UHN Software that are Site Leads, Site Members, Non-Site Members and researchers.Care Providers and Member’s employees and clinician-researchers.

“Licensee” shall have the meaning given to it in the preamble to this Agreement.

“Limited Purpose” with respect to each Licensee Member, shall mean for importing, uploading, entering, amending and accessing data of retinal blastoma retinoblastoma cancer patients solely for the purposes of either (a) in the event that the Licensed User is a member of the patient’s circle of careNon-Site Member, providing care to the patient, (b) in the event that the Licensed User is a Site Member, accessing the patient’s own information, (c) in the event the Licensed User is a Site Lead, administering permissions of Licensed Users at the site, and/or (b) in the event that the Licensed User is a researcher, accessing data in de-identified format, for patients who are part of an REB-approved study, to use in that study. For clarity, not all Licensed Users will have equal permissions and some Licensed Users will have read-only permissions. Licensee will be responsible for ensuring that permission levels are appropriate for each Licensed User.

“Licensee Member” shall mean Members who have licensed the Licensed UHN Software from the Licensee.

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“Member(s)” shall have the meaning given to it in the preamble to this Agreement.

“Non-Site Members” means users who are members of a Site Member’s circle of care.

“Purpose” shall mean (1) providing health care providers in the area of retinoblastoma worldwide to have access over a secure internet portal to the database platform supported by the UHN Software in order to contribute and access patient data for clinical use; (2) permitting Licensee, together with its authorized principal investigators and subsites, to access de-identified data to be used for research purposes; (3) providing patients, family members, guardians and their authorized legal representatives to have access to their own patient data; and (4) to contract with vendors (such as Telus and MedChart) to provide hosting services and online portal software.for collecting, entering, reviewing, managing, accessing, conducting analyses of and using the Data, in accordance with the terms of the applicable Data Bank Agreement (and/or such other agreements as entered into by the Licensee and its Members from time to time).

“Recipient” shall mean a party receiving Confidential Information from the other party under this Agreement and pursuant to and subject to the provisions of Section 8 of this Agreement.

“Research Ethics Board” or “REB” shall mean an ethics committees that oversees regulations or guidelines governing human subject studies. In some jurisdictions such committees are called institutional review boards, independent ethics committees, or ethical review boards.

“Regulatory Authorities” shall mean any (a) multinational, federal, provincial, territorial, state, municipal, local or other governmental or public department, board, bureau or agency, domestic or foreign, (b) any subdivision or authority of any of the above, or (c) any quasi-governmental or private body exercising any regulatory authority under or for the account of any of the above, including, to the extent applicable, Health Canada.

“Service Agreement” shall mean the separate service agreement to be executed concurrently with this Agreement, a copy of which will be attached hereto as Schedule “C”.

“Site Lead” means users who are healthcare providers and clinicians associated with retinoblastoma treatment centres or are otherwise associated with a retinoblastoma treatment centre and are responsible for administration of the Licensed UHN Software.

“Site Member” means users who are patients of a retinoblastoma clinic, or such person’s substitute decision maker(s).

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“Territory” shall mean Canada. In the event that the Licensee provides evidence that the UHN Software is not a medical device in other jurisdictions, UHN at its sole discretion may amend this Agreement and expand the Territory to include other countries or jurisdictions.Worldwide

“UHN” shall have the meaning given to it in the preamble to this Agreement.

“UHN Indemnitee” shall have the meaning given to it in Section 11.

“UHN Software” shall have the meaning given to it in the preamble to this Agreement.

“Updates” shall mean all reasonable bug fixes, patches, maintenance releases, minor modifications or minor revisions directly related to the Licensed UHN Software, but does not include improvements or modifications including any complimentary modules or significant new functionality of the UHN Software.

(b) Interpretation . In this Agreement: (i) words denoting the singular include the plural and vice versa and words denoting any gender include all genders; (ii) all usage of the word “including” or “include” or the phrase “e.g.,” in this Agreement shall mean “including, without limitation”; (iii) the division of this Agreement into separate Sections, Subsections and Schedule(s) and the insertion of headings is for convenience of reference only and shall not affect the construction or interpretation of this Agreement; (iv) words or abbreviations which have well-known or trade meanings are used herein in accordance with their recognized meanings; (v) if any payment is required to be made or other action is required to be taken pursuant to this Agreement on a day which is not a Business Day, then such payment or action, as the case may be, shall be made or taken on the next Business Day; (vi) time shall not be of the essence in the performance of this Agreement; (vii) the terms and conditions hereof are the result of negotiations between the parties and the parties agree that this Agreement shall not be construed in favour of or against any party by reason of the extent to which any party or its professional advisors participated in the preparation of this Agreement; and (viii) unless otherwise specified herein, all amounts specified in this Agreement are expressed in Canadian dollars.

(c) Schedules . The following Schedules are incorporated into, and form an integral part of, this Agreement:

Schedule A: UHN SoftwareSchedule B: Third Party ProductsSchedule C: Service Agreement

2. Grants and Restrictions.

[(a)] Grant. Subject to the terms and conditions of this Agreement, UHN hereby grants to Licensee a non-exclusive, royalty-free, non-transferable right license to use, copy and display to:

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(i) access and use for the Purpose, the Licensed UHN Software within the Territory;

[(ii)] grant licenses to the Members Licensed Users to access and use for the Limited Purpose, the Licensed UHN Software within the Territory, wherein the access rights granted to Members pursuant to the Software License includes the right for the Member’s employees and clinician-researchers to access the Licensed UHN Software; and

grant licenses to the Members to grant sublicenses to Care Providers who are not the Member’s employees or clinician-researchers to access the Licensed UHN Software

(together, the “Software License).

[(b)] For greater certainty, none of the Licensee, the Licensee Members or the Licensed Users will receive copies of the UHN Software source code or object code. Licensee Members and Licensed Users will obtain access to the Licensed UHN Software features and functionality (other than Documentation) through a secure internet portal to a UHN-controlled server (such as a Telus Healththird party server that is controlled by UHN)service provider which will execute the UHN Software.

(b)

[(c)] Terms Applicable to Licensee Members . Licensee shall ensure that all Licensee Members and Licensed Users are required to comply with the applicable terms and conditions of this Agreement, and any breach of a term of this Agreement by a Member or a Licensed User shall be considered a breach by the Licensee. Furthermore, any license agreement entered into by Licensee and a Member Licensed User with respect to the Licensed UHN Software shall have terms that obligate the Member Licensed User to:

[(A)] comply with restrictions at least as stringent as those set out at Section 2 (a) (iv) of this Agreement,

[(B)] comply with insurance requirements as least as stringent as those set out at Section 6 (c) of this Agreement; and

(A)[(C)] comply with confidentiality terms and obligations at least as stringent as those set out at Section 8 of this Agreement.

[(d)] Licensee Members . Upon request, Licensee shall provide to UHN a list of all Licensee Members.

[(e)] Restrictions. Licensee shall not, and shall ensure that each of its Licensee Members and Licensed Users (excluding UHN) shall not, except as otherwise expressly provided herein: (i) reproduce, copy, download, modify, create derivative works

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or distribute the Licensed UHN Software; (ii) provide, disclose, sublicense or otherwise permit any person who is not a Licensed User to access, use, distribute, copy or display the Licensed UHN Software; (iii) attempt to adapt, translate, change, customize, enhance, augment, partially delete or alter, or otherwise modify the Licensed UHN Software in any manner or to any extent whatsoever, whether in whole or in part; (iv) attempt to access the source code, or disassemble, decompile, reverse engineer, or otherwise in any manner deconstruct all or any part of the Licensed UHN Software; (v) use the Software to act as a “service bureau” or in a time-sharing, application service provider or other similar model to provide the benefit of the use of the Licensed UHN Software to any person other than a Licensed User; (vi) attempt to alter any proprietary notices appearing in the Licensed UHN Software; (vii) access the Licensed UHN Software via any means other than over the internet using authorized login credentials.

[(f)] Third Party Licenses and hardware. Licensee shall be responsible for the provision, support, and maintenance of all third party software, hardware and other licenses that may be required to use the Licensed UHN Software to ensure full functionality, including but not limited to any software and hardware listed at Schedule B including any expenses relating to the foregoing. Licensee shall furthermore comply with the third party licenses provided in Schedule B (Third Party Products).

[(g)] Installation and Access . UHN will be responsible for the installation of the UHN Software on a UHN-controlled’son a third party server and the creation and maintenance of an access portal pursuant to a separate service agreement (“Service Agreement”) to be executed concurrently with this Agreement and attached hereto as Schedule “C”.

[(h)] Updates . UHN shall make arrangements with Licensee to provide and install Updates on a UHN-controlled’s serverthird party server, when available, at no cost to Licensee. For clarity, all Updates shall be provided at UHN’s sole discretion and UHN shall be under no obligation to provide any Updates other than those specified in the Service Agreement.

[(i)] Access. UHN will use reasonable efforts to make the core functions and features of the Licensed UHN Software available to the Licensee Members and the Licensed Users. UHN will use reasonable efforts to conduct routine maintenance at times that minimize disruption of use of the Licensed UHN Software, but UHN does not warrant or guarantee the continuous availability of the Licensed UHN Software and reserves the right to perform maintenance at any time.

3. Ownership and Other Rights.

(a) UHN Software . As between the parties, Licensed UHN Software (and all Intellectual Property Rights therein) shall be the sole property of UHN. Licensee acknowledges and agrees that as between the parties, UHN retains all

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right, title and interest in and to the Licensed UHN Software and any improvements and modifications thereof.

(b) Software Improvements.

[(i)] In the event that Licensee has suggestions for modifications or improvements that it would like made to the Licensed UHN Software (“Proposed Improvements”), if agreed upon by UHN, UHN will provide Proposed Improvements for a fee-for-service rate of $125 per hour (inclusive of appropriate institutional overhead charges).

(i)[(ii)] Any Proposed Improvements shall be owned by UHN, and if applicable, Licensee shall, at UHN’s expense, execute any document or provide such assistance as is reasonably required to effect or otherwise memorialize, document or record such sole UHN ownership and title.

Non-Exclusive License. Nothing in this Agreement shall be deemed or construed to prevent or otherwise restrict UHN from entering into any further development and/or licensing agreements with any other third party in respect of the Licensed UHN Software and any Proposed Improvements. Furthermore, UHN shall retain its right(s) to utilize and exploit, directly or indirectly, all Licensed UHN Software and any Proposed Improvements for any purpose, including but not limited to internal clinical, academic and research purposes.

4. Royalties.

Royalty. In consideration of Licensee’s status as a non-for-profit organization and in consideration that Licensee will not be charging anyone a fee to access or use the Software, UHN is providing the Software to Licensee with no royalty fee or licensing fee. For purposes of clarity, Licensee must still pay the service and support fees outlined in Section 3 of Schedule C (titled Service Agreement).

5. Diligence

Diligence. Licensee commits to the following diligence provisions in order to maintain the license

a. Diligence provision 1

b. Diligence provision 2

In the event that Licensee fails to meet these diligence provision, and fails to rectify the failure within 60 days written notice from UHN, the Software License shall terminate.

6. Software Support and Maintenance.

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[(a)] Documentation. UHN shall provide Documentation to Licensee for purposes of allowing Licensee to provide the Documentation to Licensee Members for Licensee Members and Licensed Users to use and operate the Licensed UHN Software.

(a)[(b)] Additional Services. Other than as specifically provided herein, no additional services are provided pursuant to this Agreement. Any additional consulting, support and/or development services by UHN to Licensee shall be covered in the concurrent Service Agreement unless otherwise agreed to by the Parties in writing.

7. Regulatory and Compliance.

(a) Approvals.

Licensee, in its sole discretion, cost and expense, and with UHN’s reasonable assistance (which shall further be at Licensee’s expense), will be responsible to seek and obtain all regional, federal, provincial and local regulatory approvals, including those approvals (if any) required from the Regulatory Authorities (“Regulatory Approvals”), that are necessary for the use and access of Licensed UHN Software by the Licensee and Membersand Licensed Users within each new region within the Territory prior to use in that Territory. In the event that source code is required for regulatory purposes, UHN will provide the source code provided that the Parties sign agreement limiting the use of the source code for regulatory purposes.

Compliance.

[(i)] Applicable Laws. In performing its obligations or exercising its rights under this Agreement, each party agrees to comply fully with all Applicable Laws. In addition, Licensee shall ensure that each of the Licensee Members and Licensed Users agrees to comply fully with all Applicable Laws with respect to its use of the Licensed UHN Software. For greater certainty, in addition to its obligations under Section 6(a), Licensee agrees that it is solely responsible to otherwise ensure that all access to, and use of the Licensed UHN Software under this Agreement is in full compliance with all Applicable Laws.

[(ii)] Data and Privacy Laws . The Parties agree and acknowledge that the data of retinal blastoma retinoblastoma cancer patients being treated by Licensee Members in the Territory to be imported to the Licensed UHN Software by Licensee, the Licensee Members or the Licensed Users (the “Data”) may include information which meets the definition of “personal health information” as that term is defined in Ontario’s Personal Health Information Protection Act (“PHIPA”), “individually identifiable health information” as that term is defined in the United States’ Health Insurance Portability and Accountability Act (“HIPAA”),

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“data concerning health” as that term is defined in Europe’s General Data Protection Regulation (“GDPR”) (collectively, “PHI”). As such, each Party represents and warrants with respect to itself that:

(A) it shall comply with all applicable requirements and obligations under local applicable data and privacy laws (whether it be PHIPA, HIPAA, GDPR, or other);

(B) it will further require that its employees and agents, as well as (if applicable) any third parties to which it provides access to the Data under this Agreement, also comply with local applicable data and privacy laws ;

(C) it employs appropriate safeguards to prevent theft, loss and unauthorized access, copying, modification, use, disclosure or disposal of PHI;

(D) it shall (a) require all of its employees and independent contractors to sign confidentiality agreements prior to accessing the Data; (b) conduct periodic privacy and security training and testing for each of its employees and maintain a record of such training and testing; (c) maintain an incident and breach management policy with protocols for incident and breach notifications; (d) confirm its compliance with its privacy policy within 30 days of a request from the other Party; and (e) periodically provide to the other Party documentation regarding threat and vulnerability assessments that relate to the Licensed UHN Software or the Service Agreement. Each Party shall assign personnel to oversee and audit the performance of its privacy obligations who possesses skills and knowledge appropriate for the role.

(E)[(D)] when used for research in which Data is de-identified,

i. the de-identified Data shall not be used to re-identify or contact any individual whose PHI is included in the Data; and

ii. the de-identified Data shall not be used or disclosed in a form from which any individual may be identified.

Licensee furthermore represents and warrants that it, its employees and agents will comply with any limitations on the use of the PHI imposed by the provider of the Data, and such Data shall only be used by Licensee in accordance with the terms of the applicable Data Bank Agreement (and/or such other agreements as entered into by the Licensee

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and the applicable Member provider from time to time)consent or, if applicable, REB approved waiver of consent.

[(iii)] Licensee is a Health Information Network Provider s . The Parties agree and acknowledge that Licensee is a “health information network provider” as that term is defined in the regulations promulgated under PHIPA (O.Reg. 329/04, s.6(2)) (“HINP”). Licensee agrees to comply with all applicable requirements including those set forth in the PHIPA regulations.

(ii)[(iv)] No Conflicting Agreements . Licensee further represents and warrants that it has not, and shall not, enter into any agreements with third parties, including but not limited to its Members, which conflict with or are inconsistent with any of the terms of this Agreement.

8. Term and Termination

(a) Term: The term of this Agreement shall be perpetual (the “Term”), unless earlier terminated in accordance with the terms of this Agreement.

(b) Termination for Cause: Notwithstanding the foregoing, either party may earlier terminate this Agreement immediately upon the occurrence of any of the following events:

(i) Licensee losing its status as a non-for-profit organization in Canada;

[(ii)] Licensee charging a Licensee MemberLicensed User fees for using the Software or other products or services;

(ii)[(iii)] the other party failing to cure a material breach committed by it, including but not limited to any breach of Applicable Law or any failure to pay the Initial Fee or Annual Service Fee (as both terms are defined in Section 3 of Schedule C) when due, within thirty (30) days after receiving written notice thereof;

(iii)[(iv)] the institution of voluntary proceedings by the other party under bankruptcy or insolvency laws, for corporate reorganization, receivership or dissolution, or similar proceedings;

(iv)[(v)] the pendency for more than ninety (90) days of involuntary proceedings against the other party under bankruptcy or insolvency laws, for corporate reorganization, receivership or dissolution, or similar proceedings;

(v)[(vi)] the other party making a general assignment for the benefit of creditors;

(vi)[(vii)] within (30) days of receiving notice of the other party ceasing to do business or to do the business relevant hereunder. For the avoidance of

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doubt, this ground of termination shall include UHN ceasing to support or to license the UHN Software, for any reason.

(c) Effect of Termination.

(i) On the date of termination of this Agreement for a material breach under Section 8.(b)(i), or upon the occurrence of any of the events contemplated in Sections 8.(b)(iv) through (v), the license granted under this Agreement, and all licenses granted to Licensee Members thereunder, shall immediately terminate.

(ii) Upon termination of this Agreement:

[(A)] Licensee shall no longer have the right to license the UHN Software to Members and UHN will cease to provide Licensee Licensed Users Members access to Licensed UHN Software;

(A)[(B)] Licensee shall return or destroy (at UHN’s option) any physical or electronic copies of Documentation;

(B)[(C)] UHN shall provide Licensee or its authorized designee with a complete copy of its Data in a readable format agreed upon by the Parties; and

(C)[(D)] The Service Agreement shall also terminate.

(d) Survival. Sections 1, 8, 10, 10, and 11 in their entirety, Section 3 (except for Section 3(b), Section 4 (to the extent monies are owing post termination/expiration), Section 6(b)(ii), Section 7(c), this Section 7(d), and Section 12 (as required to give effect to any surviving clause), shall survive expiration or earlier termination of this Agreement.

9. Confidentiality

(a) Treatment of Confidential Information. Each Recipient receiving Confidential Information from a Discloser pursuant to this Agreement shall:

[(i)] hold confidential all Confidential Information provided by the Discloser and not disclose to persons or entities other than Recipient individuals having a reasonable need to know the Confidential Information in connection with the permitted purposes hereunder, without the prior written consent of the Discloser; provided however that Licensee may provide to Licensee MembersLicensed Users Documentation, and other information necessary to access and use the Licensed UHN Software, under obligations of confidentiality at least as stringent as those set out herein, for the sole purpose of enabling the Licensee Members and Licensed Users to access and use the Licensed UHN Software;

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(i)[(ii)] use the Confidential Information only for the purposes for which it is delivered to the Recipient, and for no other purposes whatsoever, except with the prior written consent of the Discloser; and

[(iii)] return the Confidential Information (with all copies thereof and all portions of documents prepared by or for the Recipient that contain Confidential Information) to the Discloser (or, at the option of the Discloser, destroy all Confidential Information, including all copies thereof and all portions of the documents containing Confidential Information, and provide the Discloser with a certificate of an officer of the Recipient stating that the destruction has occurred) within thirty (30) days of termination of this Agreement or upon receipt by the Recipient of a written request therefor from the Discloser except to the extent the Recipient shall have a continuing right to retain one (1) archival copy of the Confidential Information pursuant to this Agreement in order to ensure compliance with its rights and obligations provided herein. With respect to Documentation and other information necessary to access and use the Licensed UHN Software that has been provided to Licensee MembersLicensed Users in accordance with this Agreement, each Licensee MemberLicensed User shall also have a continuing right to retain one (1) archival copy of the Confidential Information in order to ensure compliance with its rights and obligations.

[(b)] Acknowledgement. Recipient acknowledges and agrees that: (i) it is responsible for compliance of Recipient individuals (including, with respect to the Licensee, the Licensee Members and Licensed Users) in possession of Discloser’s Confidential Information with the terms and conditions of this Agreement; and (ii) a breach of any Recipient’s obligations pursuant to this Agreement by any Recipient individual (including, with respect to the Licensee, the Licensee Members and Licensed Users) shall be deemed to be a breach by Recipient. Recipient agrees to cause Recipient individuals (including, with respect to the Licensee, the Licensee Members and Licensed Users) to comply with the terms of this Agreement, as if such individuals were Recipient, and shall cause said individuals to comply with any other legal or equitable obligation of Recipient. Licensee shall ensure that the Licensee MembersLicensed Users be responsible for the security and confidentiality of any usernames or passwords granted to Licensee Members and Licensed Users to access the UHN Software, and to limit disclosure of such usernames and passwords to its Licensed Users.

(b)[(c)] Exceptions. The obligations imposed by Section 9.(a) of this Agreement shall not apply, or shall cease to apply, to any Confidential Information if or when, and to the extent that, the Confidential Information:

(i) was known to the Recipient prior to the receipt of the Confidential Information from the Discloser or Discloser’s affiliates;

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(ii) was, or becomes through no breach of the Recipient’s obligations hereunder, known to the public;

(iii) becomes known to the Recipient from sources other than the Discloser under circumstances not involving any breach of any confidentiality obligation between the source and the Discloser;

(iv) is independently developed by the Recipient, without any use of or reference to the Discloser’s Confidential Information; or

(v) is required to be disclosed by law or applicable legal process, provided that the Recipient making the disclosure shall:

(A) give the Discloser as much prior notice thereof as is reasonably practicable so that the Discloser may seek such protective orders or other confidentiality protection as it, in its sole discretion and at its sole expense, may elect; and

(B) reasonably cooperate with the Discloser in protecting the confidential or proprietary nature of the Confidential Information that must be so disclosed (with this duty of cooperation not requiring the Recipient or Recipient’s individuals to initiate or participate in any litigation or incur more than de minimus out-of-pocket costs).

This obligation of confidentiality in respect of any particular Confidential Information shall survive for a period of five (5) years from the expiration or earlier termination of this Agreement.

(c)[(d)] Equitable Relief. Recipient acknowledges and agrees that due to the unique nature of the Discloser’s Confidential Information, there can be no adequate remedy at law for any breach of the Recipient’s confidentiality and use-restriction obligations under this Agreement, that any such breach may result in irreparable harm to the Discloser, and that therefore, upon any such breach or threat thereof, the Discloser shall be entitled to seek appropriate equitable relief, including injunctive relief, in addition to any remedies it may have available at law.

(d)[(e)] Exception . Notwithstanding the confidentiality obligations herein, each party shall be permitted to disclose the terms of this Agreement without the prior written consent of the other Party to those of its staff, employees, agents, advisors, accountants, auditors, shareholders, investors, potential investors, underwriters and others on a need to know basis under circumstances that reasonably ensure the confidentiality thereof, or to the extent required by law.

(e)[(f)] Confidential Information and Personal Health Information . For greater certainty, each Party acknowledges that information which is Confidential Information as defined in the Agreement may also be (but is not necessarily) personal health

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information, and vice versa, and that where information is both personal health information and Confidential Information, the requirements applicable to each category shall apply to it so as to subject it in each case to the more rigorous requirement.

10. Warranties and Disclaimers

(a) General Warranty. Each party represents and warrants to the other party that:

(i) the party has the full corporate right, power and authority to enter into this Agreement; and

(ii) when executed and delivered by the party, this Agreement will constitute the legal, valid and binding obligation of the party, enforceable against the party in accordance with its terms.

(b) Disclaimer. LICENSED UHN SOFTWARE IS PROVIDED “AS IS”. THE PARTIES EXPRESSLY DISCLAIM THE MAKING OF, AND EACH PARTY ACKNOWLEDGES THAT NEITHER PARTY HAS RECEIVED OR RELIED UPON, ANY REPRESENTATION, WARRANTY, CONDITION OR GUARANTY, EXPRESS OR IMPLIED, RELATING TO THE LICENSED UHN SOFTWARE, USE OF THE LICENSED UHN SOFTWARE FOR THE PURPOSE, OR THE RELATIONSHIP BETWEEN THE PARTIES THAT IS ADDITIONAL TO OR DIFFERENT FROM THE TERMS SET FORTH IN THIS AGREEMENT, INCLUDING ANY REPRESENTATION, WARRANTY, CONDITION OR GUARANTY AS TO THE AMOUNT OF PROFITS, INCOME OR OTHER REVENUE THAT EACH PARTY MAY EARN, OR THE AMOUNT OF INVESTMENT REQUIRED, AS A RESULT OF THE PARTIES’ RELATIONSHIP. FURTHERMORE, EXCEPT AS SET FORTH HEREIN, THE PARTIES DISCLAIM ALL OTHER EXPRESS OR IMPLIED WARRANTIES AND CONDITIONS INCLUDING BUT NOT LIMITED TO ANY IMPLIED WARRANTY OR CONDITION OF MERCHANTABILITY AND ANY IMPLIED WARRANTY OR CONDITION OF FITNESS FOR A PARTICULAR PURPOSE.

UHN DOES NOT REPRESENT OR GUARANTEE THAT THE LICENSED UHN SOFTWARE AND THE DATA HOSTED BY UHN UNDER THIS AGREEMENT WILL BE FREE FROM LOSS, CORRUPTION, ATTACK, VIRUSES, INTERFERENCE, HACKING, OR OTHER SECURITY INTRUSION, AND UHN DISCLAIMS ANY LIABILITY RELATING THERETO EXCEPT TO THE EXTENT ARISING FROM UHN’S GROSS NEGLIGENCE OR WILFUL MISCONDUCT.

11. Limitation of Liability.

EXCEPT FOR DAMAGES ARISING FROM EACH PARTY’S OBLIGATIONS UNDER SECTION 8 (CONFIDENTIALITY) AND LIABILITY UNDER THE INDEMNITY PROVISIONS OF THIS AGREEMENT, IN NO EVENT SHALL EITHER PARTY BE

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LIABLE HEREUNDER OR OTHERWISE, WHETHER FOR BREACH OF CONTRACT, NEGLIGENCE, STRICT LIABILITY, OR OTHERWISE, FOR LOSS OF PROFITS, INDIRECT, INCIDENTAL, EXEMPLARY, OR CONSEQUENTIAL DAMAGES OF ANY KIND (EVEN IF THE PARTY HAS BEEN ADVISED OF THE POSSIBILITY OF SUCH DAMAGES) ARISING FROM BREACH OF THIS AGREEMENT OR THE SERVICE AGREEMENT, OR ANY OTHER PROVISION OF THIS AGREEMENT OR THE SERVICE AGREEMENT, OR IN CONNECTION WITH THE UHN SOFTWARE, INCLUDING ANY INTELLECTUAL PROPERTY RIGHTS ASSOCIATED THEREWITH. THE ENTIRE RISK AS TO ANY USE OF THE LICENSED UHN SOFTWARE (AND ANY INTELLECTUAL PROPERTY ASSOCIATED THEREWITH), INCLUDING DATA, CONCLUSIONS OR RESULTS ASSOCIATED WITH USE OF THE LICENSED UHN SOFTWARE (AND ANY INTELLECTUAL PROPERTY ASSOCIATED THEREWITH) IS ASSUMED ENTIRELY BY LICENSEE, WITHOUT ANY LEGAL OR EQUITABLE RECOURSE TO UHN EXCEPT TO THE EXTENT THAT THE LOSSES WERE CAUSED BY UHN’S NEGLIGENCE OR WILLFUL MISCONDUCT.

12. Indemnification and Insurance.

(a) Indemnity . Licensee agrees to indemnify, save harmless, and defend UHN, its affiliates, and its and their directors, officers, researchers, inventors, employees, staff, students, and agents (the “UHN Indemnitees”), against any and all losses, damages, costs, fees, and expenses (including reasonable legal expenses) (“Losses”) incurred in connection with any third party claim, suit, demand or proceeding, to the extent arising from: (a) a material breach by Licensee, a Licensee Member (excluding UHN) or a Licensed User of any term of this Agreement or the Service Agreement, including failure to comply with Applicable Law or failure of Licensee to pay any Fees when due, (b) use of the Licensed UHN Software by Licensee, a Licensee Member (excluding UHN) or a Licensed User, or (c) use or exploitation of the data, results, conclusions, and products derived from, arising out of, or resulting from use of Licensed UHN Software under this Agreement, including but not limited to the use of any databank or the data contained with it; provided that the aforementioned obligation to indemnify shall not apply to the extent that the Losses were caused by UHN’s negligence or willful misconduct. In addition, Licensee hereby agrees to indemnify and hold harmless UHN from all costs, damages, fines, penalties or other liabilities arising out of a breach of its obligations under PHIPA, other applicable privacy legislation and regulations and this Agreement with respect to the Licensee’s failure to comply with the privacy and security terms and conditions of this Agreement, provided that this obligation to indemnify shall not apply to the extent that the costs, damages, fines, penalties or other liabilities were caused by UHN’s negligence or willful misconduct.

[(b)] Insurance. During the Term of this Agreement and for the duration of its obligations surviving expiration or termination of this Agreement, Licensee shall and shall ensure that the Licensee Members shall obtain and maintain general liability insurance in an amount of not less than $5,000,000 per occurrence and $5,000,000 aggregate. Licensee shall provide to UHN a certificate of insurance

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on behalf of itself and on behalf of each Licensee Member at such times as UHN may reasonably request from time to time during the Term or for a period of five (5) years thereafter.

13. General.

(a) Governing Law. This Agreement shall be governed by and construed in accordance with the laws of the Province Ontario and the federal laws of Canada applicable therein, and each party consents to the exclusive jurisdiction of the relevant courts of Ontario and all courts competent to hear appeals therefrom.

(b) Independent Contractors. In performing their respective obligations hereunder, each party shall act at all times as an independent contractor. Nothing in this Agreement shall be construed or applied to create a relationship of principal and agent or employer and employee between the parties, and neither of them shall make any commitment, take any action or incur any expense in the name of or purporting to bind the other party or its affiliates.

(c) Further Assurances. The parties shall, and shall cause their respective employees, agents and representatives to prepare and execute and deliver, at the request and expense of the other party, any and all documents or instruments reasonably necessary or appropriate to create, evidence, or confirm the grant, discharge or release, as the case may be, of any right, interest or obligation required by the provisions of this Agreement.

[(d)] Entire Agreement and Amendment. This Agreement (which includes all Schedules including the Service Agreement) represents the entire understanding and agreement of the parties with respect to the non-exclusive license from UHN to MCRN Licensee of the Licensed Software and supersedes all prior communications, agreements and understandings between the parties relating to such subject matter. In the event of a conflict between this Agreement and any extraneous exhibit or purchase order, this Agreement shall govern. For clarity, this Agreement shall be read in conjunction with the Data Bank Agreement, provided however that no restrictions respecting the Licensed Software set out in the Data Bank Agreement shall limit or preclude UHN from carrying out any of its rights and obligations provided in this Agreement, including the Service Agreement and any other Schedules. This Agreement may not be modified or amended except by a written instrument duly executed by both parties.

(d)[(e)] Costs and Legal Fees. The prevailing party in any action to enforce this Agreement shall be entitled to recover reasonable costs and expenses in connection with the enforcement, including reasonable legal fees and expenses.

(e)[(f)] Waivers. No right under this Agreement or breach hereof may be waived except in writing signed by the parties. The failure of either party to require performance of any provision of this Agreement shall not be construed as a

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waiver of that party’s rights to insist on performance of the provision or any other provision at some other time.

(f)[(g)] Assignment and Binding Effect. This Agreement may not be assigned by either party without the prior written consent of the other; provided, that either party may assign this Agreement in its entirety to an affiliate or successor in interest to the business of the party, upon written consent of the other party which consent shall not be unreasonably withheld, if the affiliate or successor agrees in writing with the other party to fulfill the obligations of the assigning party. This Agreement shall be binding on, and inure to the benefit of, the respective successors of the parties thereto.

(g)[(h)] Counterparts . This Agreement may be executed by the parties in counterparts by facsimile or electronically, each of which so executed or delivered will be deemed to be an original and all will constitute one agreement.

(h)[(i)] Notices. Any notice, consent, approval or other communication in connection with this Agreement, unless otherwise expressly provided for herein, shall be in writing, in English, and delivered by hand (including commercial delivery or courier services), confirmed email or facsimile, or after being mailed, postage prepaid, certified or registered mail, return receipt requested, to the address as set forth on the signature page below, or such other address as a party designates by giving notice to the other party in accordance with this Section 12(i). Any such notice, consent, approval or other communication is deemed to have been delivered and received on the date of delivery or transmission was received by the recipient party prior to 5:00 pm (Toronto time) and otherwise on the next Business Day.

(i)[(j)] Severability . Each provision of this Agreement shall be deemed separate, severable and distinct. If any part of any provision of this Agreement is found by a court to be invalid, illegal or unenforceable in any way, the finding shall not limit or affect the validity, legality or enforceability of the remaining provisions.

(j)[(k)] Force Majeure. Neither party shall be responsible for any failure to perform or delay in performing any of its obligations hereunder (including under the Services Agreement) where and to the extent that the failure or delay results from causes outside the reasonable control of the party.

The parties have caused their duly authorized representatives to execute and deliver this Agreement to be effective as of the Effective Date.

INTERNATIONAL RETINAL BLASTOMA RETINOBLASTOMA CONSORTIUM INC. UNIVERSITY HEALTH NETWORK

Per: Per:

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Name: Name:Title: Title:

Address (for correspondence/notices):International Retinoblastoma Consortium11 Rose AvenueToronto, Ontario M4X 1N6Tel (416) 294-9729Email brenda@gallie.caEngin Gul9131 Keele St. Unit A4, Vaughn, Ontario, L4K 067Tel 289-818-0982Email: egul@myeloma.ca

[INSERT CONTACT DETAILS]

Address (for correspondence/notices):Technology Development & CommercializationMaRS Centre, Heritage Building101 College StreetSuite 150Toronto, Ontario M5G 1L7Tel (416) 581-7400Fax (416) 977-4765Email tdc@uhnresearch.ca (Attn: Director)

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Schedule A – UHN Software

Description of UHN Software

Description of UHN Software:The DePICTRB (Disease-specific electronic Patient Illustrated Clinical Timeline for Retinoblastoma) system is a browser based web application that provides user friendly web forms for the collection of point-of-care clinical data on retinoblastoma patients.1. The system is composed of the following forms: Staging EUA – Exam Form Staging EUA – Imaging Form Staging EUA – Tumor Findings Form Staging EUA – Diagnosis Form Staging EUA – Procedures Form Staging EUA – Images Form Staging EUA – Plan Form EUA Form Initial Visit – Visit Details Form Initial Visit – History Form Initial Visit – Exam Form Initial Visit – Findings Form Initial Visit – Plan Form Clinic Visit - Visit Details Form Clinic Visit – Exam Form Clinic Visit – Imaging Form Clinic Visit – Tumors Form Clinic Visit – Procedures Form Clinic Visit – Plan Form Imaging Form Chemotherapy Form Radiation Form Pathology (Eye) Form Genetic Testing Form Stem Cell Transplant Form Other Surgery Form Additional Cancer Form Extraocular Extension Form Intra-arterial Chemotherapy Form Toxicity Form Patient Status Form Demographics and Circle of Care

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2. Visual representation summarizes the patient’s treatment history created from coded data.

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3. Dynamic annotation tool graphically records findings and interventions.

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Schedule B – Third Party Products

Third party software

JSON (http://www.json.org/license.html)

License to JSON is as follows:

Copyright (c) 2002 JSON.org

Permission is hereby granted, free of charge, to any person obtaining a copy of this software and associated documentation files (the "Software"), to deal in the Software without restriction, including without limitation the rights to use, copy, modify, merge, publish, distribute, sublicense, and/or sell copies of the Software, and to permit persons to whom the Software is furnished to do so, subject to the following conditions:

The above copyright notice and this permission notice shall be included in all copies or substantial portions of the Software.

THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE SOFTWARE.

Rapheal (http://raphaeljs.com/)

License to Rapheal is as follows:

Copyright © 2008 Dmitry Baranovskiy

Permission is hereby granted, free of charge, to any person obtaining a copy of this software and associated documentation files (the "Software"), to deal in the Software without restriction, including without limitation the rights to use, copy, modify, merge, publish, distribute, sublicense, and/or sell copies of the Software, and to permit persons to whom the Software is furnished to do so, subject to the following conditions:

The above copyright notice and this permission notice shall be included in all copies or substantial portions of the Software.

THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES

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OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE SOFTWARE.

JQuery (https://jquery.org/license/)

License to JQuery is as follows:

Permission is hereby granted, free of charge, to any person obtaining a copy of this software and associated documentation files (the "Software"), to deal in the Software without restriction, including without limitation the rights to use, copy, modify, merge, publish, distribute, sublicense, and/or sell copies of the Software, and to permit persons to whom the Software is furnished to do so, subject to the following conditions:

The above copyright notice and this permission notice shall be included in all copies or substantial portions of the Software.

THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE SOFTWARE.

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Schedule C – Service Agreement

This Service Agreement (the “Service Agreement”) is entered into effective as of the 13th day of June, 2017 (“Effective Date”) by and between:

University Health Network, an Ontario not-for-profit corporation incorporated under the University Health Network Act, 1997, with a business office at 101 College Street - Suite 150, Toronto, Ontario, M5G 1L7 (“UHN”); and

The International Retinal Blastoma Retinoblastoma ConsortiumMyeloma Cancer Research Network, Inc., a non-profit corporation having its primary offices at 11 Rose Avenue, Toronto, Ontario M4X 1N51800, Le Corbusier, Suite 138, Laval, QC H7S 2K1[__insert particulars here_] (“Licensee” ).

UHN and Licensee may be individually referred to as a “Party” and together as the “Parties”.

WHEREAS UHN and Licensee have entered into a Software Access and Data HostingLicense Agreement effective as of June 13th___________, 20187 with respect to the Licensed UHN Software, as defined therein (the “Access Agreement”) ;

WHEREAS Licensee wishes to have UHN provide installation and service support to allow Licensee Members and Licensed Users to access and use the Licensed UHN Software, and UHN is willing to provide such services pursuant to this Service Agreement in accordance with the terms set out herein;

NOW THEREFORE in consideration of the mutual covenants made in this Service Agreement, and other good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the parties agree as follows.

1. Access Agreement . The provisions of the Access Agreement are incorporated herein and shall apply to this Service Agreement. Should there be any discrepancy between the terms of the Access Agreement and the terms of this Service Agreement, the terms of the Access Agreement shall govern and apply unless specifically stated otherwise herein. All capitalized terms in this Service Agreement have the respective meanings given to them in the Access Agreement.

2. Services . UHN will provide the services in a professional and diligent manner and as further detailed in Appendix 1 (as amended) (the “Services”) through the health informatics research group at UHN (“HIR”), provided that Licensee has fulfilled its obligations as required in the Access Agreement and in this Service Agreement. Unless otherwise explicitly agreed to in writing by the parties, UHN will not be involved in the provision of any other service, or engage in other activity, further to this Service Agreement other than the Services unless agreed to otherwise by the Parties in writing.

3. Fees . The Parties confirm that this is a fee for service arrangement as follows:

[a.] A one-time initial fee of $114,000.00_xxxxxx__ paid by Licensee to UHN for installation, configuration, and integration of the Licensed UHN Software,

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including training, as further outlined as part of the Services in Appendix “1” (“Initial Fee”) which is due according to the following payment schedule:

Amount Due Estimated dates

$53,000xxx

Upon signing

$10,000xxx

Upon implementation of approved updates

August 1, 2017

$25,000xxx

Upon completion of code legacy data migration

September 7, 2017

$8,000xxx Upon system deployment September 31, 2017

$18,000xxx

Upon implementation of post-go live enhancements

January 8, 2018

[b.] An annual service support fee of $17,500.00xxxxxx (“Annual Service Fee”) shall be due and payable within thirty (30) days of the completion of system deployment of the Licensed UHN Software, and thereafter, prior to the anniversary of the Effective Date, as a condition precedent to renewal pursuant to Article 6. The Initial Fee and the Annual Service Fee are inclusive of an institutional overhead rate of twenty percent (20%) which amounts to $19,000xxxxx for the Initial Fee and $2,915 for the Annual Service Fee.

4. Ownership of Intellectual Property and Data . As between the parties, UHN will own all intellectual property and related information specifically and directly related to the Licensed UHN Software (which includes, without limitation, any and all modifications, coding, and new integration and methodologies related to the UHN Software arising from the provision of the Services). Notwithstanding the foregoing, ownership of any Data incorporated into the UHN Software shall be unaffected by this Service Agreement.

5. Privacy Laws .

[a.] Compliance with PHIPA . UHN warrants and represents that its use of the Data is, and will be, in compliance with PHIPA, HIPAA and GDPR (or the equivalent privacy legislation in the event that the territory for the license to the Licensed UHN Software extends out of Canada) and UHN shall use the PHI for the sole and exclusive purpose of fulfilling its obligations under this Service Agreement and for no other purpose whatsoever. Such information shall also be appropriately protected by UHN against loss, theft, unauthorized access, copying, or modification. UHN will further require that its employees and agents, as well as any third parties to which it provides access to the Data under this Service

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Agreement, also comply with PHIPA, HIPAA and GDPR (or relevant equivalent).

a.[b.] Additional Obligations. In the event that any other local or provincial privacy legislation applies to the activities of UHN required under this Service Agreement, or the Access Agreement, in relation to the Data, which requires additional obligations other than those specifically provided herein, Licensee shall be responsible for ensuring compliance with such obligations, and prior to the importation of any such Data to the Licensed UHN Software, shall notify UHN and obtain UHN’s written agreement to such additional obligations.

6. Term, Renewal and/or Termination. This Service Agreement will be in force for a period of one (1) year from the Effective Date, renewable each year, upon receipt of the Annual Service Fee, or otherwise as agreed to in writing by the Parties. At the time of any such renewal the Parties shall review and update information under Section 9 (Notices) of this Service Agreement. Notwithstanding the foregoing, either Party may:

a. upon written notice, terminate this Agreement for cause as a result of a material breach of this Service Agreement by the other Party which breach remains uncured thirty (30) days after written notice, or

b. terminate, in the Party’s sole discretion upon the provision of sixty (60) days written notice to the other Party.

7. Effects of Termination .

a. In the event of termination of this Service Agreement by the Licensee pursuant to Section 6(a) or (b) of this Service Agreement, or if UHN terminates this Service for cause in accordance with Section 6(a) of this Service Agreement, then:

i. the Parties shall immediately cease all unnecessary activities and shall cooperate to minimize all costs associated with this cessation/termination of activities associated with the provision of said Services;

[ii.] the Access Agreement shall immediately terminate and Licensee shall no longer have the right to license the UHN Software to Members and UHN will cease to provide Licensee Members access to Licensed UHN Software; and

[iii.] Licensee shall return or destroy (at UHN’s option) any physical or electronic copies of Documentation; and

b. In the event of termination of this Service Agreement by the Licensee pursuant to Section 6(a) of this Service Agreement, for cause, in addition to the actions set forth in Section 7(c)(i)-(iii) of this Service Agreement, UHN shall refund an amortized portion of the Annual Service Fee for the time remaining from the date of cessation of the Services to the anniversary of the Effective Date, minus all

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reasonable expenses and un-cancellable commitments incurred as of the date of the cessation of the Services.

c. In the event of termination of this Service Agreement by UHN pursuant to Section 6(b) of this Service Agreement, then:

i. the Parties shall immediately cease all unnecessary activities and shall cooperate to minimize all costs associated with this cessation/termination of activities associated with the provision of said Services and Licensee shall only be obligated to pay for costs of the Initial Fee that have been properly incurred up to the date of termination; and

[ii.] UHN shall refund an amortized portion of the Annual Service Fee for the time remaining from the date of the cessation of Services to the anniversary of the Effective Date, minus all reasonable expenses and un-cancellable commitments incurred as of the date of the cessation of the Services.; and

[iii.] upon request by the Licensee, UHN shall provide the Licensee with the UHN Software under the terms of a fully paid up, perpetual, non-exclusive license for the Purpose (as such term is defined in the Access Agreement), with standard terms and conditions as agreed upon between the Parties.

[8.] Exclusion of Warranties. EXCEPT AS EXPRESSLY PROVIDED IN THIS SERVICE AGREEMENT, UHN (WHICH INCLUDES ITS DIRECTORS, OFFICERS, EMPLOYEES, STAFF MEMBERS, STUDENTS, RESEARCH TRAINEES AND AGENTS) MAKES NO CONDITIONS, REPRESENTATIONS, WARRANTIES, UNDERTAKINGS, PROMISES, INDUCEMENTS OR AGREEMENTS OF ANY KIND, WHETHER DIRECT, INDIRECT, COLLATERAL, EXPRESS OR IMPLIED, AS TO ANY MATTER WHATSOEVER, INCLUDING, WITHOUT LIMITATION, THE CONDITION, ORIGINALITY, OR ACCURACY OF THE SERVICES, OR ANY OTHER DELIVERABLE OR MATTER ARISING FROM THE PROVISION OF THE SERVICES, WHETHER TANGIBLE OR INTANGIBLE, AND ANY INTELLECTUAL PROPERTY ASSOCIATED THEREWITH, CONCEIVED, DISCOVERED, OR DEVELOPED UNDER OR AS A RESULT OF THIS SERVICE AGREEMENT; OR THE OWNERSHIP, MERCHANTABILITY, OR FITNESS FOR A PARTICULAR PURPOSE OF SAID DATA, CONCLUSIONS OR PRODUCTS OR ANY OTHER DELIVERABLE OR MATTER ARISING FROM THE PROVISION OF THE SERVICES, AND ANY INTELLECTUAL PROPERTY ASSOCIATED THEREWITH, INCLUDING WITHOUT LIMITATION, ANY REPRESENTATIONS AND WARRANTIES IN RESPECT OF INTELLECTUAL PROPERTY ASSOCIATED WITH THE PROVISION OF ANY SERVICES OR IN RESPECT OF ANY DELIVERABLE OR OTHER MATTER ARISING FROM THE PROVISION OF THE SERVICES.

8.[9.] Notices. Notices may be sent by fax or mail, or as otherwise described in the Access Agreement, as follows:

a. For UHN

i. Concerning this Service Agreement:

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John ReidDirector, Technology Development & CommercializationUniversity Health Network101 College Street – Suite 150Heritage Building – MaRS CentreToronto, OntarioM5G 1L7 CanadaTel: (416) 581-7410Fax: (416) 977-4765

ii. For invoicing:

Cheryl SzombatiCompliance Specialist

Technology Development & CommercializationUniversity Health Network 101 College Street – Suite 150Heritage Building – MaRS CentreToronto, OntarioM5G 1L7 CanadaTel: (416) 581-7400Fax: (416) 977-4765

iii. For scheduling or other matter(s) re. Services:

Tran TruongTran.Truong@uhn.ca

b. For Licensee:

[Engin Gul9131 Keele St. Unit A4, Vaughn, Ontario, L4K 067Tel 289-818-0982Email: egul@myeloma.caINSERT CONTACT DETAILS]Brenda GallieInternational Retinoblastoma Consortium11 Rose AvenueToronto, Ontario M4X 1N6Tel (416) 294-9729Email brenda@gallie.ca

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9.[10.] Disputes. The Parties shall attempt to resolve any dispute relating to this Service Agreement promptly by negotiation between officials with authority to settle the matter who are at a higher level of responsibility than the persons with direct responsibility for the administration of this Service Agreement. All negotiations under this provision shall be considered confidential and shall be treated as compromise and settlement negotiations and deemed to be “off the record” and without prejudice.

10.[11.] Survival.

a. Sections 1, 5, 7, 8, 10 and 11 shall survive the expiration or earlier termination of this Service Agreement, until such time as the Parties mutually agree to the release of the obligations contained therein. In addition, the terms and provisions contained in the Access Agreement which by the terms thereof require their performance by the Parties after the completion or termination of this Service Agreement shall remain in force notwithstanding such completion or other termination of this Agreement.

IN WITNESS WHEREOF, the Parties hereto have executed this Service Agreement by their respective authorized representatives to be effective as of the date first written above.

THE MYELOMA CANCER RESEARCH NETWORK, INCINTERNATIONAL RETINAL BLASTOMA RETINOBLASTOMA CONSORTIUM.

By: ________________________________

Name:

Title:

UNIVERSITY HEALTH NETWORK .

By: ____________________________

Name:

Title:

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APPENDIX 1DESCRIPTION OF “SERVICES”

“Services” Detail(s):

The Services to be provided by UHN in accordance with this Service Agreement are as follows:

Initial setup

Deliverable/Task Responsible Est Time for Completion

Est Date of Completion*

[1.] Gather and Document System Requirements UHN Complete Upon Signing

[2.] Form Design and Build UHN Complete Upon Signing

[3.] Set up Demo Site UHN Complete Upon Signing

[4.] Receive Feedback on Demo Site (UAT) MCRN 20 days Jul 1, 2017

[5.] Implement approved updates (dependency on 4)**

UHN 20 days Aug 1, 2017

[6.] Preparing Mapping and Data for Migration MCRN 40 days*** Aug 1, 2017

[7.] Code Legacy Data Migration (dependency on 6)

UHN 25 days Sept 7, 2017

[8.] Quality Assurance UHN 10 days Sept 21, 2017

[9.] System Deployment and Training UHN 8 days Sept 31, 2017

[10.] Provide system feedback (post go-live)MCRN 40 days Nov 31, 2017

[11.] Implement Post-Go Live Enhancements (dependency on 10)

UHN 20 days Jan 1, 2018

*Date based on a June 15, 2017 signing date

** If there are additional functionality required, ie. tagging of data exports or a click through user agreement that increases the time required and additional costs. The specifications are required before the cost and schedule can be quoted.

*** 4 and 6 can be done in parallel and start upon signing

Installation, configuration and set-up of the Software on UHN Research Information Systems Web and Database Server;

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Installation and configuration of the following DePICTrbDEPICT HEALTH formseCancerCare Myeloma forms, which include:

Staging EUA – Exam Form Staging EUA – Imaging Form Staging EUA – Tumor Findings Form Staging EUA – Diagnosis Form Staging EUA – Procedures Form Staging EUA – Images Form Staging EUA – Plan Form EUA Form Initial Visit – Visit Details Form Initial Visit – History Form Initial Visit – Exam Form Initial Visit – Findings Form Initial Visit – Plan Form Clinic Visit - Visit Details Form Clinic Visit – Exam Form Clinic Visit – Imaging Form Clinic Visit – Tumors Form Clinic Visit – Procedures Form Clinic Visit – Plan Form Imaging Form Chemotherapy Form Radiation Form Pathology (Eye) Form Genetic Testing Form Stem Cell Transplant Form Other Surgery Form Additional Cancer Form Extraocular Extension Form Intra-arterial Chemotherapy Form Toxicity Form Patient Status Form Demographics and Circle of Care Amyloidosis Diagnosis Form Diagnostic Biopsy Form Blood Labs Form Blood Labs Immunology Form Bone Marrow Cytogenetics Form Cardiac MRI Imaging Form Charlson Comorbidity Score Form Chemotherapy Form Clinical Trial Form Demographics Echo Test Form Flow Cytometry Form

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Frailty Score Form Imaging Form Initial Consultation Forms 1-5 Katz ADL Form Lawton IADL Form Mayo Cardiac Score Form Minimal Residual Disease Form Multiple Myeloma Staging Form Patient Status Form PFT Form Radiation Therapy Form Risk Stratification Form Stem Cell Mobilization Form Stem Cell Transplant Form Toxicity Form Urine Labs Immunology Form Vital Signs Form EORTC_QLQ_C30 QLQ_MY20 EQ-5D

First Line Support is defined as gathering customer information and detailed description of software system issues, attempting to identify the underlying problem, and sorting through possible documented solutions. This also encapsulates training or teaching sessions on how to use various modular components of the system.

Second Line Network Support. Second Line Network Support consists of issues related to server and network infrastructure which are supported by the UHN Research Information Systems IT team. This includes, but is not restricted to:

o Web and database server downtimes, backups, upgrades and maintenanceo All other server administration issues that affect the functionality of the applicationo Network connection failureso All other network issues that affect the functionality of the program

Application Support, which includes Adaptive Maintenance (as defined below) and Corrective Maintenance (as defined below) and Bug Fixes (as defined below) will be provided with respect to Software by telephone or e-mail during regular business hours between 0900 and 1700 EST Monday through Friday excluding statutory holidays. Technical support personnel will attempt to resolve the question or problem immediately. If the question or problem cannot be resolved immediately a resolution or follow-up plan will be provided within 3 business days o Corrective Maintenance is activities associated with Bug-Fix isolation and resolution. o Adaptive Maintenance. Adaptive maintenance is defined as specific application

customization activities relating to infrastructure upgrades or major changes relating to new versions of an operating system, application server, or database software.

o Bug Fixes are emergency repairs of any system operation that does not comply with the current system specification of the Software. This includes system errors, “hung” or halted screens, or unexpected results within the system that render it unusable for the purpose for which it was designed.

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Absent a separate agreement between the Parties, the following services and activities are explicitly excluded from the Services to be provided hereunder this Service Agreement.

On-Call Support Management. UHN support personnel are not required to be on-call outside of normal business hours to support the Software. If at a later date, the Recipient requires support personnel to be on call for a specific purpose, or on a longer term basis, a separate agreement shall be formulated outlining the appropriate terms, including logistics and compensation.

Perfective Maintenance. Perfective Maintenance is defined as activities relating to enhancements, with effort of two (2) days or more that are designed to provide additional functionality to the application. Perfective maintenance includes but is not limited to new development and modifications to the original application specifications. New development and modifications can be requested and will be charged at $120/hour (inclusive of overhead).

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