wearable sensors: mjff's wearable sensor platform to quantify pd in clinical trials and across...
TRANSCRIPT
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WEARABLE SENSORS: MJFF'S WEARABLE SENSOR PLATFORM TO QUANTIFY PD IN CLINICAL TRIALS AND ACROSS PATIENT POPULATIONS
Ken Kubota Director of Data Science at the Michael J Fox Foundation
Shahar ShpigelmanIntel Big Data Analytics
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Our MissionTo accelerate the development of improved therapies, and ultimately a cure, for people living with Parkinson’s disease today.
» $500 million in research funded to date
» $70 million in research grants funded in 2014
» 1,500 projects funded to date
» 500 active grants in current portfolio
» 30% of funded project are outside of the U.S.
» Fund academics, biotechs and pharma
MJFF IS THE WORLD’S LARGEST NONPROFIT FUNDER OF PD RESEARCH
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THE PAUCITY OF “REAL” CLINICAL MEASURES, COST OF TRIALS AND THE ABILITY TO SCALE.
Need for more sensitive diverse measures
Continuous measures in the real world
Detect natural progression <1yr
AVERAGE TRIAL SIZE
< 100PATIENTS
VERY SMALLnumber of patients contribute to research
COST OF TRIALS are in the scales of
$M
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HISTORY
Big data Big data analyticsanalytics
IOTIOT
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IMPORTANT NEXUS IN TECHNOLOGY
“Biosensing wearable products being developed today could not have existed just 4 years ago”
•Bluetooth Low Energy radio, iPhone 4s was the 1st to implement•Wireless Qi charging coil standard•MEMS accelerometers price drops 5x
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PROGRAM TO IMPLEMENT WEARABLE SENSOR TECHNOLOGIES FOR PD
Aims:
•Speed trials while reducing cost
•Identify new phenotypes of Parkinson’s disease
•Improve the quality of care of Parkinson’s disease patients
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MANAGE THE DISEASE USING DATA
Data for Analysis
RESEARCHER
BIG DATA CLOUDAnalytics
INSIGHT / VALUE
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THE SYSTEM
Patient and
CLINICIAN
Clinically Meaningful Data
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OUR DATA INFRASTRUCTURE
•Patient stratification (unsupervised analysis)•Disease progression models (machine learning)•Report sharing
Historical trials
Time series data model
Historical trials
Curation
ETL tool
Patient de-identification
Initial phase of portal
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KEY LEARNING
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Iterative Design and Discovery
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CLINICAL TRIALS
CLINICAL TRIALS
Create and Validate Algorithm & Measures
L-DOPA RESPONSE TRIAL
DATA GATHERING TRIAL
SCRIPPS TREMOR TRIAL
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Population Trials
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POPULATION STUDY
Generate insightsUsing Big data
analytics
REAL PD
FOX INSIGHT WEAR
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THE ROAD AHEAD
»This Summer:
– Integration of mPower as our pilot
iPhone offering
»This Winter:
– Integration of features across both
Android and IOS as our cross platform
offering
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» Let’s free the data• Write broad consent forms that allow data to be
shared openly• Let the patient own the data
» Put research in the hands of the patient• Come to us with your ideas and proposals
CALL TO ACTION
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Q&A