Warm-Up• Write a reminder for your project, as well as the upcoming test date – get it stamped!• Update your table of contents for today!• Complete the “Before” column on the Anticipation Guide.

Date Session#

Activity Page#

1/13 & 1/14

6 Anticipation Guide & Background Notes 13

“Milk…How Sweet Is It?” Lab Guide 14

Warm-Up/Review:• What is a catalyst?• What is a genotype? • What is coevolution?

Lactose Vs. Lactase Notes (write what is in black on the slides)

• Lactose = a sugar found only in milk

• Lactase = an enzyme found in the lining of the small intestine that acts as a catalyst in the breakup of lactose into glucose, which can be digested by the body

Just FYI…Enzyme = a substance produced by a living organism that acts as a catalyst to bring about a specific biochemical reaction

Lactose Vs. Lactase

• What does lactose intolerance mean?• So what do you think lactase persistence means?

• These are genetic characteristics…so, do you think that it is more likely for people to be lactose intolerant or lactase persistent?

The Facts About Lactose Intolerance…Remember, Milk has Sugar, Fats & Proteins:• Lactose intolerant people cannot digest the sugar (lactose) in milk. • It causes diarrhea and other unpleasant symptoms • As a result, the milk “races through” the digestive system…very little of the other nutrients in the milk (fat & protein) don’t remain in the body long enough to be digested.

Milk – How Sweet Is It? Lab• Your group will have a sample of the “intestinal

fluid” of a patient. You will test the fluid to determine if your patient has the gene for lactase persistence and is able to digest milk.

• Follow the lab directions and share your data with the class by adding your data to the table on the board.

• Answer the lab questions on your sheet.

Milk – How Sweet Is It? Lab Roles• Group Leader – reads all directions and keeps group

on task; reinforces the jobs of others• Supply Manager/Clean Up – manages supplies• Math & Map Master – does calculations & is in charge

of recording math & map information (someone with a phone)

• Discussion Leader – Leads the discussion of the questions to share information with the group and the class if required

Milk – How Sweet Is It? Lab Results 2 minutesSamples Glucose levels

(mg/dL) Patient #1(Japan)

Patient #2(Kenya)

Patient #3(China)

Patient #4(Italy)

Patient #5(Papua New Guinea)

Patient #6(Finland)

Patient #7(Saudi Arabia)

Patient #8(Uganda)

Global Distributionof the

Lactase Persistence Genotype

You will analyze the distribution of lactase persistence (ability to digest milk) across a large area of the world.

1. Calculate the frequency of lactase persistence for the 3-4 regions on your strip of paper. 2. For each region, you must put a sticker on the board. If the percentage is less than 40%, place a pink sticker, if the percentage is equal to or greater than 40%, place a green sticker.

3. When you have the percentages calculated, send your Math & Map Master to place the stickers on the correct country on the map on the board.

= lactose intolerance = lactase persistence

1. Create a key for the map on your answer sheet.- One color for lactase persistence (ability to digest milk ≥ 40%)- One color for lactose intolerance (ability to digest milk < 40%)

2. Using dots or shading, duplicate the class data on the map on your note sheet.

Answer the activityquestions below the

mapon your note sheet

Global Distribution of the Lactase Persistence Genotype

Got Lactase? The Co-Evolution of Genes & Culture

Got Lactase: The Co-Evolution of Genes and Culturehttp://www.hhmi.org/biointeractive/making-fittest-got-lactase-co-evolution-genes-and-culture

• After the video, take the quiz again, put your answers in the “after” column. Answer the questions following the quiz

Global Distribution of the Lactase Persistence Genotype

Answer the reflectionquestions on the backof the video page of

your note sheet.