W. B. Trattler; C. D. Reilly; D. F. Goldberg; P. A. Majmudar; J. A. Vukich; M. Packer; E. D.

Donnenfeld

Financial DisclosuresWilliam Trattler: Consultant/Research Funding

&/OR Speaking Honoraria: AMO, Lenstec, WavetecStudy funded by an unrestricted grant from Allergan

Purpose and MethodsThe purpose of this study was to determine the incidence and

severity of dry eye in patients undergoing cataract surgeryProspective, multi-center, observational, pilot study of 143

patients at least 55 years of age that were scheduled to undergo cataract surgery.

Outcome measures Incidence of dry eye as evaluated by grade on ITF levelTBUTOSDICorneal staining with fluoresceinConjunctival staining with lissaminePatient symptom questionnaire

Patient Enrollment 143 consecutive patients (286 eyes) scheduled to undergo cataract

surgery and meeting all other inclusion/exclusion criteria were enrolled at 9 sites across the United States7 of these patients (7/143, 4.9%) were presently using Restasis

and investigators completed a questionnaire about their use of Restasis Additional data from these patients was not collected/not used

for the analysis of the remaining 136 patients (272 eyes)Of the 136 patients, 30 (22.1%) indicated a prior diagnosis of dry eye

disease If including the Restasis patients, this incidence increased to

25.9% (37/143)

Patient DemographicsAgeMean (years) 70.7SD 7.8Min 54.5Max 87.9

n %GenderMale 68 50Female 68 50

RaceAsian 11 8.1Black 5 3.8Caucasian 100 73.5Hispanic 15 11.0Other 5 3.7

ITF Scores

TBUT and Staining

•Most patients (62.9%) had an abnormal TBUT < 5 sec •76.8% were positive for fluorescein corneal staining, with 50% exhibiting positive central staining

Schirmer’s and OSDI

•21.3% of patients had an abnormal Schirmer’s score (< 5 mm)

Prevalence of Patient Symptoms

Prevalence of Patient Symptoms

•Lack of symptoms was not associated with lack of corneal staining:• 61/136 patients (44.9%) had a corneal staining score of at least 1 but a cumulative score of one or lower for burning/stinging, FBS, dryness, and painful/sore.

ConclusionsThe findings of the present study suggest that

the prevalence of dry eye signs and symptoms in patients undergoing cataract surgery is more common than frequently reported:Most patients (62.9%) had an abnormal TBUT < 5 sec 21.3% had an abnormal Schirmer’s score (< 5 mm)76.8% were positive for fluorescein corneal staining,

with 50% exhibiting positive central staining

ConclusionsDespite only the minority of patients (22.1%) ever having

received a diagnosis of dry eye, more than 30% of patients reported at least occasional stinging and burning, dryness, and foreign body sensation, with more than 40% reporting ocular itching, sensitivity to light, blurred vision, and tired/fatigued eyes.

In conclusion, increased awareness of the prevalence of dry eye signs and symptoms should lead to proactive treatment and careful monitoring for either surgically-induced dry eye or the exacerbation of dry eye disease existent prior to undergoing cataract surgery.