volume 4, issue 3 the paccm insider november 28,...

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The holidays are upon us and we have many things to look back and be thankful for in 2017. Our fall issue reflects on these numerous events during the last few months; The Richard P. and Dorothy P. Simmons Center for Interstitial Lung Disease has had several patient -related events, our researchers have received promising scores on many grants, our clinical team continues to go above and beyond in pa- tient care, and our Division is constantly in the spotlight with publications and participation in local and international conferences. Our clinical faculty and clinical services also continue to grow with addition of a pulmonary consultation service at UPMC Mercy and Pulmonary and Critical Care Medicine consults at UPMC Horizon via telemedicine. A Note from the Chief... Congratulations to all on another year of accomplishments! Here’s to a successful new year to come! In the new year ahead, be sure to continue to send us information on new achievements, recognitions, pictures of cele- brations and milestones. We hope you enjoy this issue of the PACCM Insider. —Rama Mallampalli, MD November 28, 2017 Volume 4, Issue 3 The PACCM Insider Inside this issue: Clinical Educator Retreat 2 Microbiome Bootcamp 2 Simmons Center Events 3 Clinical Educators Shine 4 Update in Internal Medicine 4 iCPET Program 4 ERS Presidential Award 5 Host to the Air Force 5 In the News 5 Holiday Fun 5 Appointments & Promotions 6 New Hires 6 Media Links 6 Grants, Awards and Notable Mentions 7 Publications 8 Fellows 9 Save the Date- Research Retreat 9 Celebrations 10 Dr. Meghan Fitzpatrick is a compassionate and highly skilled critical care physician, clinical investigator, and ICU leader in the Pulmonary, Allergy, and Critical Care Medicine Division. Dr. Fitzpatrick is a Clinical Instructor and Director of Critical Care Medicine at UPMC East and Director of the Critical Care Unit at UPMC McKeesport. She completed her medical educa- tion at the Temple University School of Medicine, and an internal medicine residency at the University of Pittsburgh Medical Center. PACCM was fortu- nate to have her remain at PACCM for fellowship training in Pulmonary and Critical Care Medicine. During her fellowship, she completed the Certificate program in Clinical Research in the University of Pittsburgh Institute for Clinical Research Education, and was awarded an Individual Training Grant for studies in Alison Morris’ lab on the role of system- ic and pulmonary aging in HIV-associated COPD. Her research was highly productive and included publications in the journals AIDS, Microbial Immunology, and BMC Pulmonary Medicine. Dr. Fitzpatrick joined the faculty in PACCM in 2014 and based on her outstanding clinical and lead- ership skills, was appointed the ICU Director at UPMC East, leading the 24/7 care of ICU patients at that facility. In 2016 she was appointed Chief of Critical Care Medicine at East, and this year was appointed the Critical Care Unit director at UPMC McKeesport. She has been successful in establish- ing clinical pathways and improving ICU care, as well as working with nursing and administrative leadership to establish a patient and family centered environment for ICU care. She remains active as a collaborator in the HIV research center, is a highly effective educator for medical students in didactic and clinical settings, and for residents, fellows and advanced care nursing students. Dr. Fitzpatrick is revered by her patients and colleagues for her ‘can do’ attitude, problem solving and teaching skills. She is an invaluable provider for UPMC, a role model for faculty and fellows, and leader in PACCM. Remarkably, she balances her work demands with being the mother of infant twins! Faculty Spotlight Meghan Fitzpatrick, MD Contributed by Joseph Pilewski, MD

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Page 1: Volume 4, Issue 3 The PACCM Insider November 28, 2017pre.dom.pitt.edu/wp-content/uploads/2018/08/paccm-insider-8-nov2017.pdf2017 European Respiratory Society (ERS) Presidential Award

The holidays are upon us and we have many

things to look back and be thankful for in 2017.

Our fall issue reflects on these numerous

events during the last few months; The

Richard P. and Dorothy P. Simmons Center for

Interstitial Lung Disease has had several patient

-related events, our researchers have received

promising scores on many grants, our clinical

team continues to go above and beyond in pa-

tient care, and our Division is constantly in the

spotlight with publications and participation in

local and international conferences.

Our clinical faculty and clinical services also

continue to grow with addition of a pulmonary

consultation service at UPMC Mercy and

Pulmonary and Critical Care Medicine

consults at UPMC Horizon via telemedicine.

A Note from the Chief...

Congratulations to all on another year of

accomplishments! Here’s to a successful new

year to come!

In the new year ahead, be sure to continue to

s e n d u s i n f o r m a t i o n o n n e w

achievements, recognitions, pictures of cele-

brations and milestones.

We hope you enjoy this issue of the PACCM

Insider.

—Rama Mallampalli, MD

November 28, 2017

Volume 4, Issue 3

The PACCM Insider

Inside this issue:

Clinical Educator Retreat 2

Microbiome Bootcamp 2

Simmons Center Events 3

Clinical Educators Shine 4

Update in Internal Medicine 4

iCPET Program 4

ERS Presidential Award 5

Host to the Air Force 5

In the News 5

Holiday Fun 5

Appointments & Promotions 6

New Hires 6

Media Links 6

Grants, Awards and Notable

Mentions

7

Publications 8

Fellows 9

Save the Date-

Research Retreat

9

Celebrations 10

Dr. Meghan Fitzpatrick is a compassionate and highly skilled critical care

physician, clinical investigator, and ICU leader in the Pulmonary, Allergy,

and Critical Care Medicine Division. Dr. Fitzpatrick is a Clinical Instructor

and Director of Critical Care Medicine at UPMC East and Director of the

Critical Care Unit at UPMC McKeesport. She completed her medical educa-

tion at the Temple University School of Medicine, and an internal medicine

residency at the University of Pittsburgh Medical Center. PACCM was fortu-

nate to have her remain at PACCM for fellowship training in Pulmonary and

Critical Care Medicine. During her fellowship, she completed the Certificate

program in Clinical Research in the University of Pittsburgh Institute for Clinical Research Education,

and was awarded an Individual Training Grant for studies in Alison Morris’ lab on the role of system-

ic and pulmonary aging in HIV-associated COPD. Her research was highly productive and included

publications in the journals AIDS, Microbial Immunology, and BMC Pulmonary Medicine.

Dr. Fitzpatrick joined the faculty in PACCM in 2014 and based on her outstanding clinical and lead-

ership skills, was appointed the ICU Director at UPMC East, leading the 24/7 care of ICU patients at

that facility. In 2016 she was appointed Chief of Critical Care Medicine at East, and this year was

appointed the Critical Care Unit director at UPMC McKeesport. She has been successful in establish-

ing clinical pathways and improving ICU care, as well as working with nursing and administrative

leadership to establish a patient and family centered environment for ICU care. She remains active

as a collaborator in the HIV research center, is a highly effective educator for medical students in

didactic and clinical settings, and for residents, fellows and advanced care nursing students.

Dr. Fitzpatrick is revered by her patients and colleagues for her ‘can do’ attitude, problem solving

and teaching skills. She is an invaluable provider for UPMC, a role model for faculty and fellows,

and leader in PACCM. Remarkably, she balances her work demands with being the mother of infant

twins!

Faculty Spotlight

Meghan Fitzpatrick, MD

Contributed by Joseph Pilewski, MD

Page 2: Volume 4, Issue 3 The PACCM Insider November 28, 2017pre.dom.pitt.edu/wp-content/uploads/2018/08/paccm-insider-8-nov2017.pdf2017 European Respiratory Society (ERS) Presidential Award

Over 40 clinical educators gathered at the Wyndham

Pittsburgh University Center on Friday, September 15

for a mini-retreat.

Discussions included clinical needs and opportunities,

strategies for academic promotion, and teaching

opportunities and resources.

Afternoon workshops focused on how to deliver

practical feedback to students and trainees, tips for

effective teaching in the clinic and at the bedside, and

strategies for dynamic larger group teaching.

Thank you to Dr. Phil Lamberty for organizing this event

and to all the faculty to presented and participated in

the day!

Clinical Educator Retreat

Above: Dr. Mark Gladwin provides opening remarks for Microbiome Bootcamp

Page 2 The PACCM Insider

Microbiome Bootcamp

The Center for Medicine and the Microbiome (CMM), led

by Dr. Alison Morris and Dr. Barbara Methé, just

celebrated it’s first year!

Part of this inaugural year included the first Microbiome

Bootcamp, held on Friday, September 20 at the

University Club. Over 100 registrants joined in the

discussions on a wide range of topics including

sequencing, human and animal microbiome sample

collection and study design, sample processing,

evaluation of organisms other than bacteria, analytics,

and applications of these techniques to real studies.

You can find out more about CMM and upcoming

events through their website: www.microbiome.pitt.edu

Above: Dr. Phil Lamberty leads Clinical Educator Mini-Retreat

Left:

Participants listen

to lecture by Dr.

Barbara Methé

Right:

Registration

and welcome

of participants

Page 3: Volume 4, Issue 3 The PACCM Insider November 28, 2017pre.dom.pitt.edu/wp-content/uploads/2018/08/paccm-insider-8-nov2017.pdf2017 European Respiratory Society (ERS) Presidential Award

The Richard P. and Dorothy P. Simmons Center for Interstitial Lung Disease is always heavily involved in patient support and care

throughout the community. We caught up with a few of these events below.

VIOLET RIPPY 5K

This annual event took place on Saturday, July 15th on Pittsburgh’s

North Shore. It was a record-breaking year with over 500 participants!

All proceeds of this event go to the Simmons Center.

FORE IPF GOLF OUTING

On Aug 21, 88 golfers convened at the Wildwood Golf Club

to enjoy an afternoon on the course, the solar eclipse, and

lots of fun. Later, 150 attendees gathered for the banquet

dinner.

SIMMONS PATIENT CRUISE

The annual Simmons Patient Gateway Clipper Cruise set sail on

Monday, October 6. The 90 attendees included patients and their

guests, and faculty and staff from the Simmons Center.

September is marked as Global Pulmonary Fibrosis Awareness Month – and once again, the

Simmons Center for Interstitial Lung Disease rose to the challenge by wearing blue to support

patients and increase awareness of pulmonary fibrosis.

Page 3 Volume 4, Issue 3

Simmons Center Events

Page 4: Volume 4, Issue 3 The PACCM Insider November 28, 2017pre.dom.pitt.edu/wp-content/uploads/2018/08/paccm-insider-8-nov2017.pdf2017 European Respiratory Society (ERS) Presidential Award

Contributed by Michael Risbano, MD, MA

Thank you to all the presenters/workshop facilitators for this year’s Body Fluid Homeostasis

(Pulmonary Section) course that ran for several weeks from October into November!

John Kreit Burton Lee Jared Chiarchiaro

Stephanie Maximous Chris Faber Matt Morrell

Charlie Atwood Mike Donahoe Joe Pilewski

Phil Lamberty Rachel Givelber Bryan McVerry

David Kristo Jessica Bon Jason Rose Keven Robinson

Erin Nuzzo Anna Zemke Ian Barbash Marc Gauthier

Craig Riley Eric Nolley Will Bain Meghan Fitzpatrick

Page 4 Volume 4, Issue 3

Clinical Educators Shine!

Update in Internal Medicine Conference

Several PACCM faculty were involved in the planning and

presentations during the recent Update in Internal Medicine

Conference on October 19-20.

Dr. Michael Donahoe and Dr. Patrick Strollo served as course

director members.

Dr. Jessica Bon led a workshop, Dr. Andrej Petrov participated

during “Lunch with the Professor”.

Dr. Burton Lee and Dr. Roy Semaan presented lectures during this

two day event. Burton Lee, MD

Roy Semaan, MD

And a shout out to those who assisted in teaching the important skill of central venous catheter insertion to the MICU/

CCU residents and medical students in July!

Phil Lamberty Stephanie Maximous Dan Zank Brian Rosborough

The invasive Cardiopulmonary Exercise Testing Program (iCPET) at UPMC utilizes a comprehensive study

to diagnose all forms exercise limitation for clinical and research purposes. The iCPET program is directed

by Michael G. Risbano, MD, MA.

iCPET utilizes breath-by-breath analysis of ventilatory gas exchange with simultaneous invasive measure-

ment of pulmonary vascular and cardiac function performed during upright cycle ergometery. Patients

undergoing iCPET have both a pulmonary artery and radial artery catheter placed and the measurements

collected include cardiac output, pulmonary artery pressures, multiple ventilatory indices, systemic

pressures and ECG variables during progressive intensity exercise provocation. In

particular iCPET testing can delineate disease states related to pulmonary arterial, pulmonary venous,

cardiac valvular, loading dynamics, autonomic, and skeletal muscle pathophysiologies that limit exercise

capacity.

Patients referred for iCPET include those with complaints of dyspnea on exertion or exercise fatigue not

fully been explained and may include patients with connective tissue disease (scleroderma), diastolic dysfunction (HFpEF),

congenital/valvular heart disease, post-pulmonary embolism, parenchymal lung disease (ILD, COPD, cystic fibrosis), and

pulmonary arterial hypertension.

From the iCPET study we develop a plan for intervention that may include pharmacologic or surgical therapies, or cardiopulmo-

nary rehabilitation, and we can identify patients who may be eligible for participation in investigational research or clinical

treatment trials. The program has successfully evaluated over 20 patients since May and we look forward to referral of

additional cases for diagnostic intervention.

Invasive Cardiopulmonary Exercise Testing Program

Michael Risbano, MD, MA

Page 5: Volume 4, Issue 3 The PACCM Insider November 28, 2017pre.dom.pitt.edu/wp-content/uploads/2018/08/paccm-insider-8-nov2017.pdf2017 European Respiratory Society (ERS) Presidential Award

Congratulations to Sally Wenzel,

MD, who recently received the

2017 European Respiratory

Society (ERS) Presidential Award

during the annual meeting in

Milan, Italy this September.

The Presidential Award is

presented by ERS to recognize an

outstanding contribution to the

strengthening of respiratory

medicine worldwide.

ERS Presidential Award 2017

Page 5 The PACCM Insider

Sally Wenzel, MD

Belinda Rivera Lebron, MD

Dr. Sally Wenzel lead a study in which tracing cell death pathway can point to drug targets

for asthma and kidney disease, among other preventable health problems. You can read

more on the story in this Pittsburgh Post-Gazette article.

Dr. Roy Semaan was included in an article in The Incline as one of sixteen young profession-

als who are working to make Pittsburgh healthier. Read this full article here.

Dr. Belinda Rivera Lebron was invited for an interview with the Tribune Review, regarding

medical assistance of victims in hurricane relief efforts in Puerto Rico. Read the full article

here. UPMC has partnered with the Pittsburgh Pirates and Brothers Brothers Foundation in

sending medical supplies and first aid kits.

In the News

Holiday Fun

Wednesday, December 20, 2017

1:00 pm – 3:00 pm

Montefiore Conference Room, NW628

Around-the-world Holiday Luncheon:

Our PACCM Family is rich in cultural backgrounds

that extend around the world!

Share your ethnic history and holiday traditions by

bringing a traditional covered dish or dessert if you

would like to participate in our Annual

Potluck Around-the-World Holiday Luncheon.

Misfit Gift Exchange:

The fun way to “REGIFT”…

Did you receive 2 copies of the same DVD movie

last year? Or would you like to conveniently “lose”

last year’s gift from your in-laws?

Rewrap it in pretty paper (without a gift tag) and

see who will bargain for your mystery gift in this

playfully competitive tradition.

Ron Poropatich, MD, with the

Center for Military Medicine

Research, hosted several Air

Force senior scientists and

officers at Pitt. The goal was to

seek Air Force support for PACCM

investigators, including a carbon

monoxide antidote program

spearheaded by Drs. Mark

Gladwin and Jason Rose.

Host to the Air Force

Ron Poropatich, MD

Page 6: Volume 4, Issue 3 The PACCM Insider November 28, 2017pre.dom.pitt.edu/wp-content/uploads/2018/08/paccm-insider-8-nov2017.pdf2017 European Respiratory Society (ERS) Presidential Award

Media Links

Page 6 Volume 4, Issue 3

Appointments and Promotions

John McDyer, MD

Associate Professor of Medicine

Conferral of Tenure

Online editions of the Respiratory Reader newsletter

are available by clicking here.

Online CME available!

Be sure to visit

www.upmcphysicianresources.com/cme

for online CME resources

Keep in touch with UPMC pulmonary news by visiting:

www.upmcphysicianresources.com/respiratory

Keep up with weekly divisional conferences

by visiting the

PACCM Web Calendar!

Clicking on an event will expand to show

speaker information.

New Hires

Seong Chul Kim – Senior Lab Specialist in Raju Reddy’s Lab Bingxian Xie – Visiting Scholar in Bill Chen’s Lab

Shaun Alexander – Lab Technician for Divay Chandra Jing Ma – Lab Specialist in Bill Chen’s Lab

Courtney Elvin – Communication I for the Asthma Institute Emily Broderick – Lab Technician for Yingze Zhang

Mark J. Brown – Technician for John McDyer

Ana Mora, MD

Associate Professor of Medicine

Tenure Stream

Welcome to all the new members of our PACCM Family!

Aisha Walker, PhD

Assistant Professor of Medicine

Page 7: Volume 4, Issue 3 The PACCM Insider November 28, 2017pre.dom.pitt.edu/wp-content/uploads/2018/08/paccm-insider-8-nov2017.pdf2017 European Respiratory Society (ERS) Presidential Award

Grants, Awards, & Notable Mentions

Page 7 The PACCM Insider

Elizabeth Hartigan, RN, MPH received the University of

Pittsburgh Staff Award for Research Service for her many

contributions to clinical research in Cystic Fibrosis and

other respiratory diseases.

Melody Porter, Administrator in the Comprehensive Lung

Center, received an Award for Commitment and

Excellence in Service (ACES) from UPMC.

Joseph Pilewski, MD presented a plenary, Lung Transplan-

tation: Challenges and Opportunities for Advanced Lung

Disease, at the 2017 North American Cystic Fibrosis

Conference. The Adult Cystic Fibrosis program also

received a Quality Improvement Award from the Cystic

Fibrosis Foundation during this annual meeting.

Daniel Kass, MD was invited as an ad hoc reviewer for the

NIH CSR Lung Injury Repair and Remodeling Study Sec-

tion (LIRR)

The Division also received news of promising scores for

the following grant submissions:

Alison Morris, MD, MS and Barbara Methé, PhD - R01:

Dysbiosis Impact on Lung Disease in HIV Study.

Jonathan Alder, PhD - R01: Telomeres, DNA Damage, and

Lung Disease.

Jason Rose, MD – K08: Discovering and Developing

Recombinant Molecular Scavenging Agents for the

Treatment of Carbon Monoxide Induced Cardiovascular

Dysfunction.

Janet Lee, MD – R01: Host Control Mechanisms Against

K. Pneumoniae Infection in the Lungs.

Kong Chen, PhD – R56: Epigenetic Regulation of

Chemokines in Lung Inflammation.

Elena Goncharova, PhD - R01: TSC2 Signaling in

Pulmonary Hypertension.

Paula Consolaro during milestone achievement ceremony

Frank Sciurba, MD presented a late breaking abstract

“Mepolizumab reduces exacerbations in eosinophilic COPD"

at the European Respiratory Society meetings. This coordinat-

ed with the publication of the recently accepted manuscript

to the New England Journal, on which Dr. Sciurba is the

senior and corresponding author.

Rachael Huff, who has been a Research Specialist with the

Ray Lab for over 8 years, has graduated from the UPMC

Shadyside School of Nursing with Honors and will soon be a

staff nurse in PACCM (10th floor)!

Krishnendu Chakraborty, PhD, a senior postdoc in Prabir

Ray’s lab, has received the highly competitive and prestigious

Ramanujan Fellowship award from the Government of India,

which has enabled him to start his own independent

research with a faculty position at the Institute of Genomics

and Integrative Biology in New Delhi, India.

Janet Lee’s medical student Minting Yu’s summer research

program abstract was selected to receive the Stephen

Phillips Award for basic science. She is a first year medical

student who was engaged in the Dean’s Summer Research

Program.

Nate Weathington, MD, PhD has received notes of positive

feedback from UPMC Horizon due to his participation and

outstanding care during several telemedicine service

consultations.

Betsy Ellenberger, CRNP received a well-deserved Above and

Beyond nomination. A patient’s family sent a detailed letter

of appreciation for her outstanding patient care.

Joy de Luna, MD also received an Above and Beyond nomina-

tion for her superb care and assistance with her patient in

optimizing medication education.

Paula Consolaro, CCRC recently celebrated 10 years as a

certified clinical research coordinator.

Keven Robinson, MD was a guest speaker for the

Department of Microbiology & Immunology Seminar Series at

Montana State University this October.

Burton Lee, MD was invited as a visiting professor to Johns

Hopkins University by the internal medicine residency

program.

Jessica Bon Field, MD and Nate Weathington, MD gave

lectures at Johns Hopkins University and Brigham Women's

Hospital as visiting professors, respectively.

Toru Nyunoya, MD received a UPP Academic Foundation

Award.

Page 8: Volume 4, Issue 3 The PACCM Insider November 28, 2017pre.dom.pitt.edu/wp-content/uploads/2018/08/paccm-insider-8-nov2017.pdf2017 European Respiratory Society (ERS) Presidential Award

Alder JK, Kass DJ. Another building in the IPF Manhattan plot

skyline. Lancet Respir Med. 2017 Oct 20. [Epub ahead of print]

Iasella SV, Stetten AZ, Corcoran TE, Garoff S, Przybycien TM,

Tilton RD. Aerosolizing Lipid Dispersions Enables Antibiotic

Transport Across Mimics of the Lung Airway Surface Even in the

Presence of Pre-existing Lipid Monolayers. J Aerosol Med Pulm

Drug Deliv. 2017 Oct 20. [Epub ahead of print]

Radder JE, Gregory AD, Leme AS, Cho MH, Chu Y, Kelly NJ,

Bakke P, Gulsvik A, Litonjua AA, Sparrow D, Beaty TH, Crapo JD,

Silverman EK, Zhang Y, Berndt A, Shapiro SD. Variable Suscepti-

bility to Cigarette Smoke-Induced Emphysema in 34 Inbred

Strains of Mice Implicates Abi3bp in Emphysema Susceptibility.

Am J Respir Cell Mol Biol. 2017 Sep;57(3):367-375.

Rosen IM, Kirsch DB, Chervin RD, Carden KA, Ramar K, Aurora

RN, Kristo DA, Malhotra RK, Martin JL, Olson EJ, Rosen CL, Row-

ley JA; American Academy of Sleep Medicine Board of Directors.

Clinical Use of a Home Sleep Apnea Test: An American Academy

of Sleep Medicine Position Statement. J Clin Sleep Med. 2017

Sep 20. [Epub ahead of print]

Herazo-Maya JD, Sun J, Molyneaux PL, Li Q, Villalba JA,

Tzouvelekis A, Lynn H, Juan-Guardela BM, Risquez C, Osorio JC,

Yan X, Michel G, Aurelien N, Lindell KO, Klesen MJ, Moffatt MF,

Cookson WO, Zhang Y, Garcia JGN, Noth I, Prasse A, Bar-Joseph

Z, Gibson KF, Zhao H, Herzog EL, Rosas IO, Maher TM, Kaminski

N. Validation of a 52-gene risk profile for outcome prediction in

patients with idiopathic pulmonary fibrosis: an international,

multicentre, cohort study. Lancet Respir Med. 2017 Sep 20.

[Epub ahead of print]

Jacobs SS, Lindell KO, Collins EG, Garvey CM, Hernandez C,

McLaughlin S, Schneidman AM, Meek PM. Patient Perceptions

of the Adequacy of Supplemental Oxygen Therapy: Results of

the American Thoracic Society Nursing Assembly Oxygen Work-

ing Group Survey. Ann Am Thorac Soc. 2017 Oct 19. [Epub

ahead of print]

Londino JD, Gullick DL, Lear TB, Suber TL, Weathington NM,

Masa LS, Chen BB, Mallampalli RK. Post-translational modifica-

tion of the interferon gamma receptor alters its stability and

signaling. Biochem J. 2017 Sep 7. [Epub ahead of print]

Mora AL, Rojas M, Pardo A, Selman M. Emerging therapies for

idiopathic pulmonary fibrosis, a progressive age-related disease.

Nat Rev Drug Discov. 2017 Oct 30;16(11):810.

Das S, Raundhal M, Chen J, Oriss TB, Huff R, Williams JV, Ray A,

Ray P. Respiratory syncytial virus infection of newborn CX3CR1-

deficent mice induces a pathogenic pulmonary innate immune

response. JCI Insight. 2017 Sep 7;2(17). [Epub ahead of print]

Ramos AR, Weng J, Wallace DM, Petrov MR, Wohlgemuth WK,

Sotres-Alvarez D, Loredo JS, Reid KJ, Zee PC, Mossavar-

Rahmani Y, Patel SR. Actigraphic Sleep Patterns and Hyperten-

sion in the Hispanic Community Health Study/Study of Latinos.

Chest. 2017 Sep 29. [Epub ahead of print]

Donaldson SH, Pilewski JM, Griese M, Cooke J, Viswanathan L,

Tullis E, Davies JC, Lekstrom-Himes JA, Wang LT; VX11-661-101

Study Group. Tezacaftor/Ivacaftor in Subjects with Cystic Fibro-

sis and F508del/F508del-CFTR or F508del/G551D-CFTR. Am J

Respir Crit Care Med. 2017 Sep 20. [Epub ahead of print]

Page 8 Volume 4, Issue 3

Publications

Yazdani HO, Chen HW, Tohme S, Tai S, van der Windt DJ,

Loughran P, Rosborough BR, Sud V, Beer-Stolz D, Turnquist HR,

Tsung A, Huang H. IL-33 exacerbates liver sterile inflammation

by amplifying neutrophil extracellular trap formation. J Hepatol.

2017 Sep 21. [Epub ahead of print]

Pavord ID, Chanez P, Criner GJ, Kerstjens HAM, Korn S, Lugogo

N, Martinot JB, Sagara H, Albers FC, Bradford ES, Harris SS,

Mayer B, Rubin DB, Yancey SW, Sciurba FC. Mepolizumab for

Eosinophilic Chronic Obstructive Pulmonary Disease. N Engl J

Med. 2017 Sep 11. [Epub ahead of print]

Shah, F, Singamsetty S, Guo L, Chuan BW, McDonald S,

Cooper BA, O’Donnell BJ, Stefanovski D, Wice B, Zhang Y,

O’Donnell CP, McVerry BJ. Stimulation of the Endogenous

Incretin Gucose-dependent Insulinotropic Peptide by Enteral

Dextrose Improves Gucose Homeostasis and Inflammation in

Murine Endotoxemia. Trans Res. 2017 (In press)

Suber T, Mallampalli RK. An Emerging Role for Megalin as a

Regulator of Protein Leak in Acute Lung Injury. Am J Respir Cell

Mol Biol. 2017 Nov;57(5):504-505.

Jimenez MA, Novelli E, Shaw GD, Sundd P. Glycoprotein Ibα

inhibitor (CCP-224) prevents neutrophil-platelet aggregation in

Sickle Cell Disease. Blood Adv. 2017 Sep 12;1(20):1712-

1716.

Amdahl MB, DeMartino AW, Tejero J, Gladwin MT. Cytoglobin at

the Crossroads of Vascular Remodeling. Arterioscler Thromb

Vasc Biol. 2017 Oct;37(10):1803-1805

Weathington NM, Kanth SM, Gong Q, Londino J, Hoji A, Rojas M,

Trudeau J, Wenzel S, Mallampalli RK. IL-4 Induces IL17Rb Gene

Transcription in Monocytic Cells with Coordinate Autocrine IL-25

Signaling. Am J Respir Cell Mol Biol. 2017 Sep;57(3):346-354.

Wenzel SE, Tyurina YY, Zhao J, St Croix CM, Dar HH, Mao G,

Tyurin VA, Anthonymuthu TS, Kapralov AA, Amoscato AA,

Mikulska-Ruminska K, Shrivastava IH, Kenny EM, Yang Q, Ros-

enbaum JC, Sparvero LJ, Emlet DR, Wen X, Minami Y, Qu F, Wat-

kins SC, Holman TR, VanDemark AP, Kellum JA, Bahar I, Bayır H,

Kagan VE. PEBP1 Wardens Ferroptosis by Enabling Lipoxygen-

ase Generation of Lipid Death Signals. Cell. 2017 Oct 19;171

(3):628-641.e26.

Lai Y, Li J, Li X, Zou C. LPS modulates p300 and Sirt1 to pro-

mote PRMT1 stability via a SCF-Fbxl17-recognized acetyldegron.

J Cell Sci. 2017 Sep 7. [Epub ahead of print]

Han S, Olonisakin TF, Pribis JP, Zupetic J, Yoon JH, Holleran KM,

Jeong K, Shaikh N, Rubio DM, Lee JS. A checklist is associated

with increased quality of reporting preclinical biomedical re-

search: A systematic review. PLoS One. 2017 Sep 13;12

(9):e0183591. eCollection 2017.

Page 9: Volume 4, Issue 3 The PACCM Insider November 28, 2017pre.dom.pitt.edu/wp-content/uploads/2018/08/paccm-insider-8-nov2017.pdf2017 European Respiratory Society (ERS) Presidential Award

John Evankovich, MD and Tomeka Suber, MD have both been

approved for NIH Loan Repayment Funding.

Andrea Levine, MD– was selected to give the presentation, “Drug

Discovery for PH-HFpEF: High Throughput Screening in Identification of

SIRT3 Activators” at the Thirteenth Annual Respiratory Disease Young

Investigators’ Forum on October 12-15 in Denver, Co.

Will Bain, MD - received a promising score on his recent F32 grant

submission: "Mechanisms of Platelet Protection in Pathogen-triggered

Lung Injury."

Alison Lennox, MD was selected to give the presentation "ATP12A

promotes mucus dysfunction during type 2 inflammation" at the 2017

North American Cystic Fibrosis Conference in Indianapolis, Indiana in

November 2017. In addition, she was selected as a top 5 finalist for

the “Junior Investigator Best Abstract in Basic Science Award".

Marc Gauthier, MD was selected to give the presentation "CXCL10 and

Severe Asthma, a Possible Agent for Steroid Insensitivity " at the 2017

Nemacolin Asthma Conference and also to present his work at

the Asthma and Allergic Diseases Cooperative Research Centers

program meeting at the NIH.

Page 9 Volume 4, Issue 3

Fellows

Bryan McVerrry hosted a party this summer to welcome to all of our new

fellows! Faculty and fellows alike had a wonderful time!

Annual Fellows Research Retreat

Presentations by Fellows

Special Guest Speaker, Lynn M. Schnapp, MD

Center /Institute Highlights

Research Faculty Presentations

Traditional Bowling Competition

Save the Date—Fellows Research Retreat

Page 10: Volume 4, Issue 3 The PACCM Insider November 28, 2017pre.dom.pitt.edu/wp-content/uploads/2018/08/paccm-insider-8-nov2017.pdf2017 European Respiratory Society (ERS) Presidential Award

Division of Pulmonary, Allergy and

Critical Care Medicine-PACCM

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Editor-in-Chief: Rama Mallampalli, MD

Deputy Editor: Keven Robinson, MD

Senior Editor and Creative Designer: Terri Dobransky

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BIRTHS

Congratulations to our growing PACCM

family!

Sudipta and Tanay Das welcomed son,

Hrehaan Advik, on November 27.

Jessica and Mark Stanard welcomed son,

Elijah Nathaniel, on November 22.

Dan and Jenny Zank welcomed daughter,

Philippa Therese, on November 1.

Carl and Lindsey Koch welcomed son, Otis

Paul, on October 12.

Craig and Sarah Riley welcomed daughter,

Elodie Claire, born October 9.

Eric and Kristin Nolley welcomed son,

Garris, on September 25.

Alyssa and Mike Gregory welcomed son,

Edward Dominick, on September 12.

Kaylee and Jeremy Klingensmith

welcomed daughter, Rylee Nicole, on

September 5.

Anna Marie and Greg Chekan welcomed

grandson, Julian Alexander, on August 9.

Below Philippa Therese Zank Below, Otis Paul Koch

Left,

Elodie Claire Riley

with dad, Craig

Above, Edward Dominick Gregory

Above,

Garris Nolley with dad, Eric

Above, Rylee Nicole Klingensmith

Left,

Julian Alexander

with grandmother,

Anna Marie

Right,

Elijah Nathaniel

Stanard

with mom,

Jessica

Above, Hrehaan Advik Das