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TRANSCRIPT
Vol 18 No3 September 2020
A comparison of remifentanil and low dose fentanyl for postopera-tive recovery prole in patients undergoing minimally invasive cardiac surgery
Human factors underlying adverse medical events revisit root cause analysis cases using the hfacs
Juvenile caruncular atypical lymphoid proliferation a rare case report
Hyperacute intramembranous hemorrhage after burr hole cranios-tomy for chronic subdural hematoma
Hamartoma of the breast a case report
Issued and edited by Center of Medical Education College of Medicine Fu Jen Catholic University
Fu-Jen Journal of Medicine Vol 18 No 3 September 2020
CONTENTS
Original Research Article
A Comparison of Remifentanil and Low Dose Fentanyl for Postoperative Recovery
Profile in Patients Undergoing Minimally Invasive Cardiac Surgery
Meng-Chieh Ho Wei-Horng Jean Tzu-Yu Lin Cheng-Wei Lu 89
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 99
Case Report
Juvenile Caruncular Atypical Lymphoid Proliferation ndash A Rare Case Report
Hua-Wei Shih Yu-Chi Lin 112
Hyperacute intramembranous hemorrhage after burr hole craniostomy for chronic
subdural hematoma
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh 120
Hamartoma of the breast A case report
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin 126
Fu-Jen Journal of Medicine Vol 3 No 1 2020
Remifentanil versus fentanyl for MICS
Meng-Chieh Ho Wei-Horng Jean Tzu-Yu Lin Cheng-Wei Lu 89
Submitted October 17 2019
Final version accepted November
01 2019
Original Research Article
A Comparison of Remifentanil and Low
Dose Fentanyl for Postoperative Recovery
Profile in Patients Undergoing Minimally
Invasive Cardiac Surgery
Cite as Meng-Chieh Ho
Wei-Horng Jean Tzu-Yu Lin
Cheng-Wei Lu
A Comparison of Remifentanil
and Low Dose Fentanyl for Post-
operative Recovery Profile in
Patients Undergoing Minimally
Invasive Cardiac Surgery
Fu-Jen Journal of Medicine 3(1)
89-98 2020
DOI
103966181020932020091803001
Meng-Chieh Ho1 Wei-Horng Jean12 Tzu-Yu Lin12 Cheng-Wei
Lu12
1Department of Anesthesiology Far Eastern Memorial Hospital Ban-
qiao Dist New Taipei City Taiwan 220 2Department of Mechanical Engineering Yuan Ze University Taoyuan
Taiwan 320 Contributed equally
Corresponding author E-mail address
drluchengweigmailcom (Cheng-Wei Lu)
ABSTRACT
Background The concept of enhanced recovery after surgery (ERAS) is flourishing in multiple specialties including cardiac surgery Beside minimally invasive surgical ap-proach short acting anesthetic agent is one of the major components of ERAS programs Remifentanil is an ultrashort acting opioid agent The purpose of this study was to compare remifentanil and low dose fentanyl for postoperative recovery profile in patients undergoing minimally invasive cardiac surgery (MICS) Methods This study was a retrospective study We compared the recovery profile including extubation time after surgery length of hospi-tal stay postoperative morphine consumption pain scores and in hospital complication rate between patients undergoing elective MICS from May to August 2018 Results Fifty-three patients were enrolled in this study 33 of them were in group remifentanil (G remifentanil) and 20 were in group fentanyl (G fentanyl) The extubation times average hospital stay postoperative morphine consumption pain scores and in hospital complication rate were all similar between both groups Conclusion We consider remifentanil can be safely used in MICS and provides similar recovery profile as low dose fentanyl
Keywords minimally invasive cardiac surgery enhanced recovery after surgery opioids
Fu-J
Meng
INTThe (ERAcialtiperfopostoof stinvaenhaac surecovwithmajolizatiRemμ-opnonsnot aits pconsgerydurintroverospand MICfurth
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TRODUCconcept of en
AS) is gaininies Early traormed after operative recotay in intensivsive surgical
ance recovery urgery (MICSvery time w
h those of coor componention of a sho
mifentanil an pioid receptorspecific esteraaccumulate afpharmaceuticasidered as safey [8] Howeveng a fast-trackersial results ective study tsafety of remi
CS and to deher facilitates r
ATERIALretrospective
pt includes fis from 18 to 8MICS betweeents with a hientanyl pregnsing medical ents were moe oximetry a
metry cerebraectral index (
al echocardiopharyngeal temiratory and e
xide and sevnitored and reed with midakg of the bod
and rocuronght A doubled to provide oration The pups Patients ie induced withght and receivbody weight a
of Medicine V
Wei-Horng Je
CTION nhanced recovng popularity acheal extubat
cardiac surgovery and to
ve care unit (ICapproach is a[1] Minimal
S) is proven with recovery onventional sut of ERAS prort acting aneultra-short a
r agonist is ase [7] and fter prolongedal properties
fe and effectiver applicatiok cardiac surg[9-11] We coto investigateifentanil in paetermine wherecovery
LS AND Me study reportifty-three pat80 years) whoen May 2018 istory of allergnant women
records weronitored with
arterial and ceal near-infrar(BIS) monitorography (TEmperature re
expiratory oxyvoflurane conecorded All azolam 25 mdy weight denium 1 mge lumen endotone-lung ventatients were in group fentah fentanyl 5 μ
ved bolus doseas required du
Vol 3 No 1 2
Remifentani
an Tzu-Yu Lin
very after surin multiple
tion is commgery to enhreduce the leCU) A minimanother metholly invasive cato have a shooutcomes onurgeries [2-5ograms is thesthetic agent
acting and pometabolized
therefore it d infusion Du remifentani
ve for cardiac n of remifengery yielded onducted thisthe effective
atients undergether remifen
METHODted in this mtients (rangingo underwent eand August 2gy to remifenand patients re excluded h a 5-lead Eentral venous red spectroscr and transesoE) In addiectal temperaygen and carncentrations wpatients weremg etomidatexamethasonekg of the btracheal tube tilation duringdivided into
anyl (G fentaμgkg of the bes of 1-2 μgk
uring the opera
2020
il versus fenta
n Cheng-Wei
rgery spe-
monly hance ength mally od to ardi-orter
n par ] A
e uti-[6]
otent d by does ue to il is sur-
ntanil con-
s ret-eness going ntanil
DS manu-ng in elec-
2018 ntanil
with All
EKG ma-
copy oph-ition ature arbon were e in-te 2 e 10 body was
g the two
anyl) body kg of ation
Patiwerthe of 1sia centbetwwasoid the valuteremanSimagecentnicaendlumFor tienphinsurgtientiento twaslock20 (numrecoeratencaneaccothe be tcomsurgeratcomstayposacquacquhouorderamdevcatecy Mordenusinof p
nyl for MICS
i Lu
ients in Groupre induced witbody weight
1-5 μgkgh thwas maintaintration requirween 40 and s managed bydose and gas basis of TEE
ue Inotropes ed in cases whnagement of
milarly intraopd by adjustintration folloardipine or ni
dotracheal tubmen endotrach
immediate pnts were admne thirty mingery For posnts were ant-controlled ahe ICU unders morphine 1kout time of 1ml The mormerical scaleorded every 8tion Anesthesed anesthesiosthesia Extubording to a wpatients were
transferred oumes of this stugery and mortive days 1 2
mes included hy pain scorestoperative dayuired compliuired complic
urs and the 3ed For statis
meters were dviation and weegorical paramand were comrphine consu
noted as meding Mann-Whip = 005 was s
p remifentanilth remifentanand received mhroughout thened by sevoflured to mainta
60 Intraopery fluid supplem
concentrationE findings CV
and vasopreshere other methe intraopera
perative hyperg the opioid owed by aitroglycerin T
be was replacheal tube at thpostoperative
ministered withnutes prior to toperative padministered
analgesia (PCAr sedation Re mgml and b
10 minutes anrphine consume 0-10) and 8 hours for 5 sia was adminologists specbation was perweaning protoe stabilized thut of the ICUudy were extrphine consum
2 3 and 5 Thospital stay s at rest and ys 1 2 3 anications Instacations and r30-day mortalstical analysidenoted as mere compared
meters were dmpared using Fumption and an and quartitney U test Aet for all statis
il (G remifennil 05-10 μgmaintenance d
e surgery Aneurane with aain the BIS rative hypotement and then were adjusteVC level andssor were admethods failed irative hypotenrtension was dose and gasadministrationThe double luced with a she end of suranalgesia al
h 10 mg of the conclusio
ain control alintravenous
A) and transfegimen of IV bolus 1 ml w
nd a 4-hour limmption pain
side effects days after th
nistered by excialized in carformed in theocol (Fig1) they were rea The primarytubation time mption on po
The secondarypostoperativeon movemen
nd 5 and hoances of hore-operation ility rate wereis continuous
mean and stand using t-test wdenoted as freqFisherrsquos exactpain score
iles and compA significance stical tests
90
ntanil) kg of doses esthe- con-value nsion e opi-ed on d BIS minis-in the nsion man- con-
n of umen single rgery ll pa-mor-
on of ll pa-
pa-ferred PCA
with a mit of score were
he op-xperi-ardiac e ICU Once dy to
y out-after
ostop-y out-e ICU nt on spital spital in 48 e rec-s pa-ndard while quen-t test were
pared level
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REFiftyand nyl cmeanifentfemaenteeG remonhypety-repictewas remiwas for Gmonclam796 patieμgkreceithesiclamstantextubfentaaverwas 244 avereratipitalfentathe d= 0patiere-opand tanilphinativeeratimorpdiffeG rscorespec(Figpatieifent
DISThisof re
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ESULTS y-three patienwere divided consisted of 2n age ~ 64 ytanil consistedale mean ageen patients inemifentanil u
n comorbiditieertension and elated and othed in Table 1)47 hours for
ifentanil whil355 hours f
G remifentannary bypass wmp time was 6
minutes for ents in G fekg of fentanylived 196 μgia duration o
mp duration act (Table 2) Abation was 11anyl and G rage hospital 118 days an days For page hospital sive ICU stay wl acquired coanyl and 212difference wa34) Two paent in Gperation withvascular inju
l died within ne consumptioe day 1 howeive day 5 Thphine consumerent howeveremifentanil pes were obse
ctive of the p 3) Side effeent in G fenttanil experienc
SCUSSIOs research failemifentanil ov
of Medicine V
Wei-Horng Je
nts were enrolinto the two
20 patients (1years p=0104d of 33 patiees ~ 58 yearsn G fentanyl aunderwent vales across both
diabetes meher demograp The mean anG fentanyl a
le the mean dufor G fentanynil In cases
was performed82 minutes foG remifenta
entanyl were while those kg of remifeoperation durcross the two As shown in 126 hours andremifentanil stay of patiennd postoperatiatients in G stay was 124 was 284 daysomplications in G remifs not statistictients in G
G remifentahin 48 hours ury One patie
30 days poson was the higever it decrearoughout the mption was r it was slighpatients (Fig erved across batient being a
ects of PCA wanyl and 2 pacing nausea
ON led to demonsver low dose
Vol 3 No 1 2
Remifentani
an Tzu-Yu Lin
lled in this sgroups G fe
3 male 7 fem4) while G rents (15 male p = 0104) and 25 patienve surgery C
h groups inclullitus (comorbphic data arenesthesia duraand 5 hours fouration of suryl and 375 hwhere cardio
d the mean cor G fentanylanil On averadministered
in G remifenentanil The aration and cgroups were Table 3 tim
d 1496 hours respectively
nts in G fentive ICU stay remifentanildays and pos
s The rate of was 30 in
fentanil howeally significanfentanyl and anil underw
due to bleent in G remi
st-operation Mghest on postoased up to pos
5-day periodnot significa
htly higher am2) Similar
both groups at rest or mo
were rare withatients in G r
strate the effifentanyl in sh
2020
il versus fenta
n Cheng-Wei
study enta-male rem-
e 18 Sev-
nts in Com-uded bidi-
e de-ation or G rgery hours opul-cross l and rage
d 84 ntanil anes-cross con-
me to in G The
tanyl was
the stop-hos-
n G ever nt (p
one went
eding ifen-Mor-oper-stop-
d the antly
mong pain irre-
oving h one rem-
cacy hort-
eninMICcantrecethossurgreduisteristerresustuddossionpreotivelatiosimmanwascruivenfectsugthe Thitimeremthrepatiin tHowdiscmaylizeimmafteis aologmaydonThemedresonot ICUstraICUfentto incardprogintrhightiveedutherdrai
nyl for MICS
i Lu
ng the extubatCS Previous t difference eiving remifese receiving logery [12] Othuced extubatiored remifentared sufentanults may be dy agents anding strategy mns The extubaoperative lune fluid manageon manageme
milar lung comnagement In s applied to aitment was pe
ntilation Thests of confoungested that thsubtler the d
s research ree with remife
mifentanil mayeshold level ients includedthe ICU accowever the stacretion of ICUy be prolonge Previous re
mediate extuber cardiac surgat the discretiogists [14] Thy have been ne owing to thee ERAS progdical costs anources Howeshorten the h
U Engoren etated similar lenU in patientstanyl [915] Tncreased costdiac surgery gram consistsaoperative ahlights key ce risk assessmeucation prehrapy multimoin removal an
tion time in presearch has
in extubationentanil infusiow dose fenta
her studies shoon time amonnil as oppose
nil [1013] Tattributable t
d populations may also lead ation time mayg disease smement and inent However
morbidity and paddition pro
all patients anerformed at thse measures mnding factors he longer the
difference betweports an incentanil howey have beenand thus wa
d in this researording to a wart of the weaU physicians ed to allow thesearch has
bation can be gery if the exon of the supehe extubation shortened hoe current hosp
gram was estand improve uver the use o
hospital stay ot al and Chength of stays s administereThe use of rems [9] The ERwere recentl
s of three staand postoperaomponents inent patient ophabilitation odal analgesiand ambulation
patients underg found no sig
n time in paion compare
anyl during caowed evidenceng patients aded to those adThese conflito a differen A variable oto diverse co
ay be influencemoking periontraoperative vr our patientsperioperative
otective ventilnd manual lunhe end of oneminimized thA previous
e ventilation ween groups creased extubever the effen lower thanas undetectedrch were extuweaning protaning is up t
s and the weahe patient to demonstrated
e performed sxtubation startervising anesttime in our
owever it wapital policies ablished to reutilization of of remifentanior length of steng et al dein the hospita
ed remifentanmifentanil als
RAS guidelinely publishedages preoperative Each ncluding preoptimization pagoal-direct
a early extuban [16] William
91
going gnifi-tients
ed to ardiac e of a dmin-dmin-icting ce in
opioid onclu-ed by
opera-venti-s had fluid
lation ng re-e-lung he ef-study time [13]
bation ect of n the d All bated tocol to the aning stabi-
d that safely t time thesi-study
as not
educe f ICU il did tay in emon-al and nil or so led es for The ative stage
opera-atient fluid
ation ms et
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RE1
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and Li et al sway with subtay in the hospid consumptonstrated a rer medical cAS protocol [1ERAS protocoutilization of a
results did erence in the ption across balso detected and in patienifentanil infusbutable to -accumulatingresults the pparable betwe
ances of hype observed thanic postopera Side effects of hospital acunrelated to r
tanil is conside fentanyl for Mre are limitatition The retritably led to s studied mayxtubation timential benefit o
her masked bAS protocol Tto all cardiac sincluded in th
ONCLUSIresearch faile
emifentanil ovarly extubatiohospital and IC
CS The postoppain score wie obtained afanyl As a resefficiently u
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successfully absequent impropital and ICU tion [17] Leduced extub
cost upon im18] Thereforeol itself is effea specific opionot demonstrpostoperativ
both groups a higher pos
nts receiving sion [2021]
the short g property ofpostoperative een the two grralgesia wereat remifentaniative pain afte
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dered to be eqMICS ions to this srospective napotential bias
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used in MICSquired to detetients undergo
CES Lamelas J Door minimallycritical reviewfic information
Vol 3 No 1 2
Remifentani
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applied the ERovement in leand postopera
Li et al furbation time anmplementatione we theorizeective rather oid [1019] rate a signifi
ve morphine Previous resestoperative opan intraoperaThis anomal
half-life f remifentanilpain scores wroups Further recorded Hoil does not leaer cardiac surwere rare andlications was As a result r
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strate the effifentanyl in te
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nil were similaation of low anil can be saS Research ermine the roloing MICS
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w of scientificn The Journa
2020
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ABLES
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Vol 3 No 1 2
Remifentani
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remifentanil
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le 2 Operation
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ss clamp
ns)
aoperative op
kg)
aoperative
kghr)
ne output (mlk
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pital stay (day
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n characteristi
on (hrs)
n (hrs)
duration
pioid dose
IV fluid
kghr)
ative outcome
n (hrs)
ys)
U stay (days)
)
Vol 3 No 1 2
Remifentani
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ics
G remifentan
(n=33)
50 (09)
375 (098)
796 (336)
196 (77)
1191 (625)
25 (175)
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G re
(n=3
149
124
284
7 (21
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(n=
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35
68
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10
26
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33)
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12)
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fentanyl
=20)
7 (06)
55 (066)
82 (161)
4 (18)
004 (347)
6 (179)
G fentany
(n=20)
1126 (24
118 (49)
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Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang
99
Submitted October 11 2019
Final version accepted February
02 2020
Original Research Article
Human Factors Underlying Adverse
Medical Events Revisit Root Cause Anal-
ysis Cases Using the HFACS
Cite as Yu-Hsun Cheng
Sheng-Hui Hung Tung-Wen Ko
Pa-Chun Wang
Human Factors Underlying Ad-
verse Medical Events Revisit
Root Cause Analysis Cases Using
the HFACS Fu-Jen Journal of
Medicine 3(2) 99-111 2020
DOI
103966181020932020091803002
Yu-Hsun Cheng1 Sheng-Hui Hung
12 Tung-Wen Ko
3 Pa-Chun
Wang14
1Department of Quality Management Cathay General Hospital Taipei
Taiwan
2Institute of Health Policy and Management National Taiwan Universi-
ty Taipei Taiwan
3Center for Healthcare Quality Management Cheng Hsin General Hos-
pital Taipei Taiwan
4Fu Jen Catholic University School of Medicine New Taipei City Tai-
wan
Corresponding author E-mail address
drtonyseednettw (Pa-Chun Wang)
ABSTRACT Background Appropriate management of adverse medical events (AMEs) is the corner-
stone of patient safety Root cause analysis (RCA) is used to investigate serious or
high-frequency errors but is limited by its inability to explain a broader scope of factors
We re-reviewed RCA cases to understand the underlying human organizational or system-
ic factors affecting AMEs Methods A total of 40 consecutive RCA cases (2012-2016) were
retrieved from the AMEs database A panel was organized to retrospectively re-review these
cases using the Human Factor Analysis and Classification System HFACS Results For
active failures errors stemmed largely from performance-based (95) judgment and deci-
sion-making errors (875) Incorrectly followed procedures (816) and accidental
equipment operation (50) were the most common types of performance-based errors In-
adequate real-time assessment (686) and inappropriate operative actions (686) were
the most common decision-making errors For sources of latent failure teamwork problems
(275) including failure to effectively communicate (818) and communicate critical
information (727) were common Inadequate supervision (929) or command over-
sights (929) were the most common problems related to inadequate supervision (35)
Organizational programpolicy risks not adequately assessed (50) were the most common
problems related to policy and process problem (25) Conclusions The HFACS review
enhances our understanding of human factors underlying AMEs The HFACS reveals latent
supervisory organizational or systematic problems that cannot be addressed through tradi-
tional RCA Keywords patient safety adverse events root cause analysis human factors
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 100
INTRODUCTION Patient safety involves the reduction of patient
harm from potentially avoidable unintended
outcomes [1] Studies have revealed that 50ndash
80 of adverse medical events (AMEs) are pre-
ventable [2-4] to eliminate such errors the ap-
propriate management of AMEs hence repre-
sents the cornerstone of patient safety work
Through incident reporting investigation and
analysis healthcare providers can correct or
re-engineer their care processes to prevent inci-
dent recurrence [25] One of the most popular
tools for investigating AMEs is root cause anal-
ysis (RCA) RCA reconstructs a chain of errors
to identify the deviation of care from normal
processes Nonetheless with a lack of standard-
ized nomenclature and investigation procedures
RCA report conclusions are sometimes too sub-
jective and nonspecific to facilitate any actiona-
ble safety improvement plans [5-7] According
to the UK Health and Safety Executive defini-
tion human factors are environmental organiza-
tional occupational or individual human char-
acteristics which influence behavior at work
such that health and safety are affected [8] Hu-
mans and systems are prone to errors and stud-
ies have showed that nearly 70 of medical
errors involve human factors [2-4] Reasonrsquos
Swiss cheese model described the penetration of
causative human errors through layers of defen-
sive barriers leading to system collapse [9]
With much focus on the temporal sequence and
severity of departure from accepted practices in
an incident the effectiveness of RCA is often
challenged by its incapability of exploring un-
derlying human organization or even systemic
factors [5-7] Reason and others have proposed
that errors can occur at 4 levels 1) unsafe acts
(operator actions) 2) preconditions for unsafe
acts (environmental factors contributing to er-
rors) 3) inadequate supervision (management
actions affecting the operator) and 4) organiza-
tional influences (organizational culture policies
and procedures that affect the operator) [9]
Based on this theory Wiegmann and Shappell
developed the Human Factor Analysis Classifi-
cation System (HFACS) to describe human fac-
tors causing accidents from 4 tiers of categories
Each of these categories consists of nanocodes to
represent specific human behavior or system
problems leading to errors [9-10] The tier for
unsafe acts involves actual provider actions (er-
rors or rule violations) directly leading to events
The tier representing preconditions for unsafe
acts includes operational personnel and envi-
ronmental factors The supervision tier addresses
leadership problems operational planning fail-
ure or correction and supervisory ethics The
tier for organizational influences deals with re-
source management organizational climate and
operational processes (Supplement Table 1) The
HFACS provides standardized investigation
processes for the systematic analysis of common
causes of adverse events across national defense
nuclear power navy aviation and healthcare
industries Taiwan launched its nationwide
AME-reporting system the Taiwan Patient
Safety Reporting System (TPR) in 2004 RCA
methodology was subsequently introduced to the
healthcare industry by the Joint Commission of
Taiwan [11] Since 2012 appropriate manage-
ment of AMEs has been listed as a national pa-
tient safety goal [12] RCA is required by the
Ministry of Health and Welfare for major AMEs
Aside from RCA a comprehensive structural
reliable and valid framework is urgently re-
quired to further guide organizational or even
national patient safety policies In this study we
used the HFACS to review our RCA cases aim-
ing to investigate human factors underlying se-
vere or frequent AMEs
MATERIALS AND METHODS Through continuous sampling 40 consecutive
RCA cases (2012-2016) were retrieved from a
hospitalrsquos (Cathay General Hospital Taipei
Taiwan) AME-reporting system database The
database contains AMEs relating to areas such as
medication patient falls surgery transfusion
clinical care public accidents security hospital
violence tube-related complication unplanned
cardiopulmonary resuscitation laboratory testing
and examination and anesthesia The RCA cases
were sentinel or high-frequency events classified
according to severity assessment category (SAC)
[1113] The SAC is an evaluation method for
categorizing AMEs by severity of effect on pa-
tients health and risk of incident reoccurrence
The HFACS has been modified (from the US
Department of Defense version 70) and trans-
lated into Mandarin Chinese with authorization
from the original developers [10] The Chi-
nese-version HFACS for Taiwan is a valid in-
strument (content validity index 09 Cronbachrsquos
α gt07 interrater reliability Κ 04-10) equiva-
lent to the original English version [9] The
HFACS contains 4 tiers 13 subitems and 109
nanocodes (Supplement Table 1) A panel of 6
reviewers was established All reviewers were
from clinical or management (quality and patient
safety management) backgrounds Reviewers all
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 101
finished human factor education and were
trained to use the HFACS through a consensus
meeting Each RCA case was randomly assigned
to 2 reviewers Human factors leading to partic-
ular AMEs were identified and confirmed when
2 reviewers reached agreement The distribution
of errors among tiers subitems and nanocodes
are provided with descriptive statistics () The
study was approved by the Institutional Review
Board of Cathay General Hospital
(CGH-P105095)
RESULTS AMEs related to laboratory testing and examina-
tion (n = 16) clinical care (n = 9) and medica-
tion (n = 7) were the most commonly observed
in the RCA Most AMEs in this cohort are
ranked as being SAC level 3 (n = 15) or 4 (n =
17) (Table 1)
Acts (Active Failures)
This tier of errors contains 3 subitems and 13
nanocodes In the 40 RCA cases perfor-
mance-based errors for 38 (95) and judgment
and decision-making errors for 35 (875) com-
prised the most common error types with viola-
tion for 6 (15) less common Procedure fol-
lowed incorrectly for 31 out of 38 (816) was
the most common performance-based problem
Inadequate real-time risk management for 24 out
of 35 (686) was the most common judgment
or decision error All of the rule violations were
workaround types for 6 out of 6 (100) (Figure
1)
Preconditions(Latent Failures)
This tier of errors has 9 subitems and 58 nano-
codes In the 40 RCA cases teamwork for 11
(275) and environmental for 8 (20) factors
contributed to most of the errors with mental
and physical state the next most common factor
for 7 (175) Communication for 9 out of 11
(818) and information relay for 8 out of 11
(727) were the most common issues related to
teamwork Few contributors mentioned failures
related to technical errors for 4 (50) or physi-
cal for 1 (125) environment Not paying at-
tention for 4 out of 7 (571) and negative habit
transfer for 4 out of 7 (571) were common
mental contributes noted for 7 (100) Overcon-
fidence was the most common problem related
to emotional status for 4 out of 7 (571) Fa-
tigue was observed in only 2 cases for 2 out of 2
physical problems (100) (Figure 2)
Supervision(Direct Supervisory Chain of
Command)
This tier of errors contains 3 subitems and 17
nanocodes In the 40 RCA cases inadequate
supervision for 14 (35) and inappropriately
planned operations for 11 (275) factors con-
tributed to most of the respective errors fol-
lowed by supervisory violations for 7 (175)
Supervisory or command oversights for 13 out
of 14 (929) were the most common sources of
supervision inadequacy Authorized unnecessary
hazards for 7 out of 11 (636) were the most
common inappropriately planned operations
Failure to enforce rules for 6 out of 7 (857)
was the most common supervisory violation
(Figure 3)
Organization Influence (Upper-Level Man-
agement)
This tier of errors contains 4 subitems and 18
nanocodes In the 40 RCA cases policy and
process issues for 10 (25) and resources prob-
lem for 8 (20) were major concerns Few of
the respective problems are related to climate
and cultural influences for 2 (5) or to person-
nel selection and staffing for 1 (25) Poorly
assessed organizational programs or policy risks
for 5 out of 10 (50) were the most common
policy and process problems Failure to provide
adequate operational information resources for 4
out of 8 (50) and command and control re-
source deficiency for 3 out of 8 (375) were
the main resource management problems Little
was revealed regarding organizational climate
and culture (n = 1 out of 2 50) or staffing for 1
out of 1 (100) (Figure 4)
DISCUSSION Health care is a complex system comprising
many high-reliability organizations (HROs) The
vulnerability of HROs stems from the participa-
tion of multidisciplinary teams in the processes
along a variety of patient care timelines How-
ever humans and systems are inherently prone
to errors the appropriate management of AMEs
is acknowledged to be the cornerstone of patient
safety AMEs should be reported investigated
analyzed and handled appropriately[14] Theo-
retically by analyzing the pattern of key defects
providers can fix errors and re-engineer their
care processes to reduce the possibility of AME
recurrence Taiwan established its nationwide
TPR in 2004 so far 7000 health care facilities
have participated and the database has accumu-
lated more than 055 million AMEs[11] Infor-
mation generated from the TPR database can
improve patient safety at individual organiza-
tional or even national levels However despite
relentless efforts few substantial improvements
have been achieved in patient safety [15-17]
Since its introduction in Taiwan in 2006 the use
of RCA for AMEs has encountered some diffi-
culties 1) No structural and standardized
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 102
framework exists for investigation
cross-institution variability and interrater relia-
bility are often ignored 2) Conclusions are often
subjective and corrective recommendations are
less actionable relying on individual reviewersrsquo
professional backgrounds and their experiences
3) Much focus on event reconstruction and oper-
ator performance means that factors relating to
human behavior organizational culture and
system weakness are not comprehensively ad-
dressed [671718] Traditionally attempts to
improve patient safety in the health care industry
are largely reactive in nature identifying and
correcting errors in care processes [1920]
Causes of defects are not thoroughly understood
Proactive approaches must be taken to address
systematic problems within a complex system
[720] Research suggests that human error is a
causal factor in the occurrence of AMEs AME
investigation targets have moved from skill defi-
ciency toward decision-making attitudes super-
visory factors and even organizational climate
or culture HFACS methodology is based on the
Swiss cheese model that also emphasizes active
and latent failures [921] The study provides
some noteworthy findings First most AMEs as
expected involve active failures such as failure
to follow procedure accidental operation of
equipment inadequate real-time risk manage-
ment and inappropriate action These are all
sharp ends in classic RCA environment physi-
cal and mental factors are less prevalent This
proves that retrospectively determining addi-
tional causal factors is difficult when infor-
mation has not been collected during preliminary
investigation (Figure 1) Second team-
work-related problems particularly in relation to
communication and information relay are well
addressed This may be attributed to the dec-
ade-long institution-wide routine crew resource
management training in the respective research
hospital (Figure 2) Third the HFACS success-
fully reflects the importance of supervisory roles
in the occurrence of AMEs and this cannot be
overlooked (Figure 3) Fourth latent failures
especially in organizational climate or cultural
dimensions have been less frequently addressed
in incident reports a limitation of traditional
RCA However the HFACS review suggests
room for improvement in resource allocation and
policy modification within the hospital The
results of studies can make the organization
think about how to improve the patient safety
and management process from the perspective of
human factors such as improving the comfort of
the working environment and replacing and
equipment resources to prevent personnel from
affecting the medical quality and patient safety
due to the environment or equipment Need to
appropriate assessment of applicability and ade-
quate training of manpower is required The
management and control of risks should be fully
evaluate and grasp resource management and
leaders need to participate in and promote medi-
cal quality and patient safety activities to en-
hance its culture (Figure 4) No panacea exists
to ensure patient safety and improvement targets
originate largely from event investigation find-
ings Unfortunately factors identified from
AMEs are often self-explanatory with little value
for further action correction Reinforcement of
policy or processes redundant education or
repetitious training are formulaic overprescribed
RCA recommendations The use of HFACS in
this study proves that a structural prospective
AME investigation format can potentially help
with proactive patient safety management We
suggest developing an interview guideline for
the routine use of HFACS as a complement to
RCA in every AME investigation This study is a
retrospective study The underlying human fac-
tors can be under-estimated owing to the lack of
related information in the original RCA reports
CONCLUSION The HFACS review in this study enhances our
understanding of human factors in AMEs that
had previously been insufficiently scrutinized
Aside from active process and communication
errors the HFACS enables the prospective in-
vestigation of latent supervisory organizational
or systematic problems that cannot be addressed
through traditional RCA
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Incidence of adverse events and
negligence in hospitalized patients results
of the Harvard Medical Practice Study I N
Engl J Med 1991324370-376
2 Wang CH Shih CL Chen WJ et al
Epidemiology of medical adverse events
perspectives from a single institute in
Taiwan J Formos Med Assoc
2016115434-439
3 Vincent C Simon R Sutcliffe K et al
Errors Conference Executive Summary
Acad Emerg Med 200071180-1182
4 Taitz J Genn K Brooks V et al
System-wide learning from root cause
analysis A report from the New South
Wales Root Cause Analysis Review
Committee Qual Saf Health Care
2010191-5
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 103
5 Hutchinson A Young TA Cooper KL et
al Trends in healthcare incident reporting
and relationship to safety and quality data
in acute hospitals results from the
National Reporting and Learning System
Qual Saf Health Care 2009185-10
6 Mitchell RJ Williamson AM Molesworth
B et al A review of the use of human
factors classification frameworks that
identify causal factors for adverse events
in the hospital setting Ergonomics
2014571443-1472
7 Gurses AP Ozok AA Pronovost PJ Time
to accelerate integration of human factors
and ergonomics in patient safety BMJ
Qual Saf 201221347-351
8 Health and Safety Executive Introduction
to human factors
httpwwwhsegovukhumanfactorsintro
ductionhtm
9 Wiegmann DA Shappell SA A human
error approach to aviation accident
analysis The human factors analysis and
classification system Burlington VT
Ashgate Publishing Ltd 2003
10 Yu-Hsun Cheng Sheng-Hui Hung
Tung-Wen Ko et al An Analysis of the
Reliability and Validity of Human Factors
Analysis Classification System in Medical
Adverse Events Journal of Healthcare
Quality 20191370-76
11 Taiwan Joint Commission on Hospital
Accreditation Taiwan Patient-Safety
Reporting System Annual Report 2017
New Taipei City Taiwan
12 Taiwan Patient Safety Net
httpwwwpatientsafetymohwgovtwCo
ntentzMessagesslistaspxSiteID=1ampMm
mID=621273300317401756
13 Government of Western Australia
Department of Health
httpsww2healthwagovauArticlesS_T
Severity-assessment-codes
14 Farley DO Haviland A Champagne S et
al Adverse-event-reporting practices by
US hospitals results of a national survey
Qual Saf Health Care 200817416-423
15 Shojania KG Thomas EJ Trends in
adverse events over time why are we not
improving BMJ Qual Saf
201322273-277
16 Levitt P Challenging the systems approach
why adverse event rates are not improving
BMJ Qual Saf 2014231051-1052
17 Kellogg KM Hettinger Z Shah M et al
Our current approach to root cause
analysis is it contributing to our failure to
improve patient safety BMJ Qual Saf
201726381-387
18 Khorsandi M Skouras C Beatson K et al
Quality review of an adverse incident
reporting system and root cause analysis of
serious adverse surgical incidents in a
teaching hospital of Scotland Patient Saf
Surg 2012621
19 Diller T Helmrich G Dunning S et al
The Human Factors Analysis
Classification System (HFACS) Applied to
Health Care Am J Med Qual
201429181-190
20 Carayon P Xie A Kianfar S Human
factors and ergonomics as a patient safety
practice BMJ Qual Saf 201423196-205
21 Reason J Human Error New York
Cambridge University Press 1990
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 104
TABLE
Table 1 Incidences by Category (N=40)
CategorySAC SAC 4 SAC 3 SAC 2 SAC 1 total
Laboratory and ex-
amination events
4 10 2 0 16 (400)
Clinical care event 6 2 1 0 9 (225)
Medication event 5 0 2 0 7 (175)
Surgery-related event 1 1 2 0 4 (100)
Transfusion-related
event
1 1 0 0 2 (50)
Tube event 0 1 0 0 1 (25)
Public accident 0 0 1 0 1 (26)
Total 17 (425) 15 (375) 8 (200) 0 40 (100)
SAC 1113 Severity Assessment Code SAC
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 105
FIGURES
Figure 1 Active Failures (N=40)
16 (167)
66 (1000)
640 (150)
235 (57)
735 (200)
2435 (686)
2435 (686)
3540 (875)
438 (105)
438 (105)
738 (184)
1938 (500)
3138 (816)
3840 (950)
0 5 10 15 20 25 30 35 40
Commits WidespreadRoutine Violation
Performs Work-Around Violation
Ignored a CautionWarning
Failure to Prioritize Tasks Adequately
Wrong Choice of Action During an Operation
Inadequate Real‐Time Risk Assessment
Rushed or Delayed a Necessary Action
Breakdown in Visual Scan
Over-ControlledUnder-Controlled AircraftVehicleSystem
Unintended Operation of Equipment
Procedure Not Followed Correctly
Performance-Based Errors
Judgment and Decision Making Errors
Violations
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 106
Figure 2 Preconditions (Latent Failures or Conditions) (N=40)
14 (250)
24 (500)
48 (500)
11 (1000)
18 (125)
840 (200)
0 5 10 15 20 25 30 35 40
Seat and Restraint System Problems
Instrumentation amp Warning System Issues
Noise Interference
Environment
Physical Environment
Technological Environment
27 (286)
27 (286)
27 (286)
37 (129)
47 (511)
47 (571)
77 (1000)
24 (500)
44 (1000)
47 (571)
12 (500)
22 (1000)
27 (286)
740 (175)
0 5 10 15 20 25 30 35 40
Technical or Procedural Knowledge Not Retained After Training
InterferenceInterruption
Task OverUnder Saturation
Distraction
Negative Habit Transfer
Not Paying Attention
Complacency
Overconfidence
Physical IllnessInjury
Fatigue
Physical and Mental State
Physical Problem
State of Mind
Mental Awareness
211 (182)
311 (273)
311 (273)
411 (364)
811 (7227)
911 (818)
1140 (275)
0 5 10 15 20 25 30 35 40
Inadequate Task Delegation
TaskMission PlanningBriefingDebriefing Inadequate
Failure of CrewTeam Leadership
StandardProper Terminology Not Used
Critical Information Not Communicated
Failed to Effectively Communicate
Teamwork
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 107
Figure 3 Supervision (Direct Supervisory Chain of Command) (N=40)
Figure 4 Organization Influence (Upper-Level Management Command Level) (N=40)
114 (71)
114 (71)
214 (143)
314 (214)
1314 (929)
1440 (350)
511 (455)
511 (455)
711 (636)
1140 (275)
47 (571)
67 (857)
740 (175)
0 5 10 15 20 25 30 35 40
Selected Individual with Lack of Proficiency
Improper Role‐modeling
Failed to Provide Proper Training
Failed to IdentifyCorrect Risky or Unsafe Practices
SupervisoryCommand Oversight Inadequate
Performed Inadequate Risk Assessment ‐Formal
Selected Individual with Lack of Current or Limited Experience
Authorized Unnecessary Hazard
Allowing Unwritten Policies to Become Standard
Failure to Enforce Existing Rules
Supervisory Violations
Planned Inappropriate Operations
Inadequate Supervision
12 (500)
12 (500)
240 (50)
110 (100)
510 (500)
1040 (250)
11 (1000)
140 (25)
18 (125)
18 (125)
38 (35)
48 (500)
840 (200)
0 5 10 15 20 25 30 35 40
Organizational Over-confidence or Under-confidence in Equipment
Organizational Culture (attitude actions) Allows for Unsafe TaskMission
Purchasing or Providing Poorly Designed or Unsuitable Equipment
Organizational ProgramPolicy Risks not Adequately Assessed
Failure to Provide Adequate Manning Staffing Resources
Failure to remove inadequate worn-out equipment in timely manner
Inadequate infrastructure
Command and control resources are deficient
Failure to provide adequate operational information resources
Resource Problems
Personnel Selection amp Staffing
Policy and Process Issues
ClimateCulture Influences
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 108
Supplement Table 1- HFACS Content of Human Factor Analysis Classifi-
cation System [9] Tier main level sub-item nano code
Tier 1 Unsafe Acts
Perfor-
mance-Based
Errors
Unintended operation of equipment
Checklist not followed correctly
Procedure not followed correctly
Over-controlledunder-controlled aircraftvehiclesystem
Breakdown in visual scan
Rushed or delayed a necessary action
Judgment amp De-
cision-Making
Errors
Inadequate real‐time risk assessment
Failure to prioritize tasks adequately
Ignored a cautionwarning
Wrong choice of action during an operation
Violations
Performs work-around violation
Commits widespreadroutine violation
Extreme violation-lack of discipline
Tier 2 Preconditions
Environment
Physical environment
Environmental conditions affecting vision
Vibration effects vision or balance
Heatcold stress impairs performance
External force of object impeded an individualrsquos
movement
Lights of other vehiclevesselaircraft affected vision
Noise interference
Technological environment
Seat and restraint system problems
Instrumentation amp warning system issues
Visibility restrictions (not weather related)
Controls and switches are inadequate
Automated system creates unsafe situation
Workspace incompatible with operation
Personal equipment interference
Communication equipment inadequate
Physical and
Mental State
Physical problem
Substance effects (alcohol supplements medications
drugs)
Loss of consciousness (sudden or prolonged onset)
Physical illnessinjury
Fatigue
Inadequate adaptation to darkness
Dehydration
Body sizemovement limitations
Physical strength amp coordination (inappropriate for
task demands)
Nutritiondiet
State of mind
Psychological problem
Life stressors
Emotional state
Personality style
Overconfidence
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 109
Pressing
Complacency
Motivation
Motivational exhaustion (burnout)
Sensory misperception
Motion illusion-kinesthetic
Turning illusionbalance-vestibular
Visual illusion
Misperception of changing environment
Misinterpreted misread instrument
Misinterpretation of auditorysound cues
Spatial disorientation
Temporaltime distortion
Mental awareness
Not paying attention
Fixation
Task overunder saturation
Confusion
Negative habit transfer
Distraction
Geographically lost
Interferenceinterruption
Technical or procedural knowledge not retained after
training
Inaccurate expectation
Teamwork
Failure of crewteam leadership
Inadequate task delegation
Rankposition intimidation
Lack of assertiveness
Critical information not communicated
Standardproper terminology not used
Failed to effectively communicate
Taskmission planningbriefingdebriefing inadequate
Tier 3 Supervision
Supervisory Vio-
lations
Failure to enforce existing rules
Allowing unwritten policies to become standard
Directed individual to violate existing regulations
Authorized unqualified individuals for task
Planned Inappro-
priate Operations
Directed task beyond personnel capabilities
Inappropriate team composition
Selected individual with lack of current or limited experience
Performed inadequate risk assessment ‐formal
Authorized unnecessary hazard
Inadequate Su-
pervision
Supervisorycommand oversight inadequate
Improper role‐modeling
Failed to provide proper training
Failed to provide appropriate policyguidance
Personality conflict with supervisor
Lack of supervisory responses to critical information
Failed to identifycorrect risky or unsafe practices
Selected individual with lack of proficiency
Tier 4 Organizational
Influences
Resource Prob-
lems
Command and control resources are deficient
Inadequate infrastructure
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 110
Failure to remove inadequate worn-out equipment in timely
manner
Failure to provide adequate operational information resources
Fail to provide adequate funding
Personnel Selec-
tion amp Staffing
Personnel recruiting amp selection policies are inadequate
Failure to provide adequate manning staffing resources
Policy amp Process
Issues
Pace of ops-tempoworkload
Organizational programpolicy risks not adequately assessed
Provided inadequate procedural guidance or publications
Organizational (formal) training is inadequate or unavailable
Flawed doctrinephilosophy
Inadequate program management
Purchasing or providing poorly designed or unsuitable equip-
ment
ClimateCulture
Influences
Organizational culture (attitude actions) allows for unsafe
taskmission
Organizational over-confidence or under-confidence in equip-
ment
Unit missionaircraftvehicleequipment change or unit deacti-
vation
Organizational structure is unclear or inadequate
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 111
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
以 HFACS重新檢視根本原因分析案例挖掘造成醫療不良
事件之人為因素
鄭伃洵 1洪聖惠 12柯彤文 3王拔群 14
中文摘要
背景醫療不良事件(AMEs)的管理是促進病人安全的基石根本原因分析
(RCA)是探討重大病人安全不良事件問題但是由於無法解釋更廣泛的因素而受
到限制本研究使用人為因素分類與分析工具(HFACS)回溯審視醫療不良事件
以了解影響醫療不良事件的人為因素及各層面中錯誤原因之分佈或系統性問題
方法本研究回溯 2012-2016年間有做過根本原因分析之醫療不良事件以連續
性取樣方式(continuous sampling)收集 40例醫療不良事件以人為因素分類與分
析工具(HFACS)去系統性的挖掘每件案例發生錯誤之原因結果在行為層面中
分析結果主要為基礎技能錯誤(95)判斷和決策錯誤(875)其中在基礎技能
錯誤當中以未依程序作業執行(816)及未如預期設備操作(50)佔多數判斷和
決策錯誤中以現場風險評估不確實(686)及採取錯的步驟行為(686)佔多數
而在先決條件層面中以團隊合作(275)為主要因素包含溝通不良(818)及重
要訊息未以正確的方式即時傳達(727)佔多數在監督層面當中以監督不周
(929)或監督不妥當(929)為主要因素在組織政策和流程方面(50)以組織
系統的政策風險未充分評估(35)為主要因素結論本研究進一步了解醫療不
良事件在過去使用根本原因分析未探討到的人為因素反映出潛在的監督組織
行為或系統性的問題促進病人安全預防錯誤再發生
關鍵字病人安全醫療不良事件根本原因分析人為因素
1國泰醫療財團法人國泰綜合醫院 品質管理部
2國立臺灣大學健康政策與管理研究所
3振興醫療財團法人振興醫院 醫療品質管理中心
4輔仁大學醫學院
通訊作者王拔群 電子信箱 drtonyseednettw
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin 112
Submitted January 20 2020
Final version accepted April13
2020
Case Report
Juvenile Caruncular Atypical Lymphoid
Proliferation ndash A Rare Case Report
Cite as Hua-Wei Shih Yu-Chi Lin
Juvenile Caruncular Atypical
Lymphoid Proliferation ndash A Rare
Case Report Fu-Jen Journal of
Medicine 3(3) 112-119 2020
DOI
103966181020932020091803003
Hua-Wei Shih1 Yu-Chi Lin
1
1Department of Ophthalmology Shin Kong Wu Ho-Su Memorial Hos-
pital Taipei City Taiwan
Corresponding author E-mail address
yuchi067gmailcom (Yu-Chi Lin)
ABSTRACT
Lesions of the caruncle are very rare Most caruncular lesions are benign though there were still few reported malignant lesions Ocular adnexal lymphoproliferative disease (OALD) one of the differential diagnosis of caruncular lesion is seldom seen in young pa-tient In this article we report a 16-year-old boy with recurrent caruncular atypical lym-phoid proliferation We discuss the epidemiology clinical features images histomorpholo-gy and treatment between ocular adnexal lymphomas (OAL) and reactive lymphoid hyper-plasia (RLH)
Keywords caruncular lesion ocular adnexal lymphoproliferative disease ocular adnexal lymphoma
reactive lymphoid hyperplasia atypical lymphoid proliferation
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
113
INTRODUCTION Lesions of the caruncle are very rare Differen-
tial diagnosis includes nevus myeloproliferative
disorders tumors inflammation infection cysts
vascular lesions and fibrous Biopsy is essential
for diagnosis Levy J et al reported ocular ad-
nexal lymphoproliferative disease (OALD) was
relatively uncommon diagnosis among caruncu-
lar lesions [1]
OALD was seldom described in Asian popula-
tion especially for young age C-Y Cheng re-
ported age-standardized incidence of ocular
adnexal lymphomas (OAL) in Taiwan from 1979
to 1996 was below 07 per million per year and
mean age was 531 years old [2] In 2015 five
Taiwanese cases of OAL whose age ranging
from 45 to 64 were presented [3] However
there were few cases of conjunctival OAL or
RLH in Chinese pediatric patient
Here we present a case of 16-year-old boy with a
caruncular mass at his left eye with recurrence
one month after excision We describe his clini-
cal symptoms photographs pathological results
management and follow-up clinical course in
this report
CASE REPORT A 16-year-old healthy boy presented a mass
lesion at his left eye caruncle accompanied with
the symptom of tearing for one month (Figure 1)
He had no ocular pain no itchiness no blurred
vision no night sweating no fever and no body
weight loss The patient denied systemic diseas-
es and histories of surgery His bilateral best
corrected visual acuity (BCVA) were 66 and
intraocular pressure (IOP) were both within
normal range There were no remarkable find-
ings for his cornea lens fundus and physical
examination Excision was performed and the
mass was soft with fluid inside therefore con-
junctival pyogenic cyst was our initial diagnosis
However one month after the excision a pro-
truding mass recurred at the patientrsquos nasal can-
thus of left eye (Figure 2) There were some
differences compared to previous condition At
the first time the soft mass was contained in a
well-defined cyst wall which more favored py-
ogenic granulation However after short period
of recurrence solid consistency and unclear
margin were found which favored malignancy
Besides the mass partially involved beyond the
gray line of nasal part lower eyelid whereas last
time the cyst mainly extended from conjunctiva
of caruncle The second excisional biopsy was
performed Pathologic examination demonstrat-
ed abundant atypical lymphoid proliferation
(Figure 3A 3B) Immunohistochemical studies
showed that the lymphoid aggregation was
composed predominantly of CD20-positive cells
(Figure 3C) focal positive staining of CD3
(Figure 3D) CD5 CD23 CD10 and negative
staining of cyclin-D1 Unfortunately the cellular
morphology was difficult to be evaluated due to
marked crushing artifact Thus malignant lym-
phoma cannot be excluded totally
Orbital computed tomography (CT) showed a
lesion of soft tissue density at medial canthus of
left orbit without obvious nasolacrimal duct or
bony invasion (Figure 4A) Magnetic resonance
imaging (MRI) with contrast showed strong
enhancement at left medial canthus region (Fig-
ure 4B) There was no remarkable finding in the
systemic workup including complete blood
count and differential count biochemical pro-
files and 18F-fluoro-2-deoxyglucose positron
emission tomographycomputed tomography
(18F-FDG PETCT) indicating no evidence of
systemic involvement
After the second excision we preferred con-
servative management for him due to the uncer-
tainty of malignancy and to avoid side effects
from aggressive treatment No sign of recurrence
was noted after 10 months of observation The
follow-up photo was taken at three months after
the second operation (Figure 5)
DISCUSSION Ocular adnexal lymphoproliferative disease
(OALD) consists of the spectrum of lymphoid
disease affecting the tissues surrounding the eye
including ocular adnexal lymphomas (OAL) and
lymphoid hyperplasia (LH) [4] The conjunctiva
is an important location for extranodal lympho-
ma development which comprises 25 of OAL
[5]
OAL can be grouped into two categories based
on their appearance of cells under the micro-
scope low-grade and high-grade [6] Extranodal
marginal zone lymphoma of mucosa-associated
lymphoid tissue (EMZLMALT) is the most
common subtype of OAL followed by follicular
lymphoma [7-9] Both of the above are
low-grade lymphomas
LH can be further divided by histopathology into
reactive lymphoid hyperplasia (RLH) and atypi-
cal lymphoid hyperplasia (ALH) RLH has to-
tally benign morphology and immunophenotype
whereas ALH has borderline lesions between
RLH and lymphoma [10] OAL and LH are
mostly seen in patients with age between 50-70
years old There are rare cases in pediatric group
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
114
[71011] In the C-Y Chengrsquos statistical report of
OAL in Taiwan only 8 patients were younger
than 15 years old among the 101 cases of ocular
lymphoma [2] According to an US study inci-
dence rates of OAL were analyzed in different
age groups the group of age over 50 had the
highest incidence rate of 574 per million per-
son-years while the 0-19 age group had the
lowest incidence rate of 009 per million per-
son-years [12] The incidence of LH was even
less than OAL [13]
Patients with OALD may be asymptomatic or
with symptoms of proptosis eyelid swelling a
palpable painless mass or conjunctival salmon
patch Diplopia visual loss pain or inflamma-
tion occurred less frequently implying more
aggressive features [714]
Orbital LH is not distinguishable from low-grade
lymphoma radiologically They both typically
present a round or lobulated mass that diffusely
moderately enhances with contrast and usually
shows homogenous hypointense or isointense to
muscle barely invasion to bone or nervous sys-
tem [10] Atypical appearances including inho-
mogeneous calcification or bony changes may
be seen in high-grade lymphoma case reports
such as ocular adnexal diffuse large B-cell lym-
phoma (DLBCL) which is one of the more ag-
gressive type of OAL [7] Whole body PET is
used for not only the evaluation of systemic
involvement but also the standard for staging
lymphoma Our patientrsquos image studies revealed
neither obvious local invasion nor systemic ma-
lignancy indicating high-grade lymphoma was
less likely Low-grade lymphoma and benign
reactive lymphoid hyperplasia were still under
consideration
Histomorphology analysis and immunohisto-
chemistry (IHC) are essential for diagnosis
Flow cytometry and polymerase chain reaction
(PCR) technique are also applied to help differ-
entiate from RLH and OAL [1016] Our case
had immunohistochemical profile of positivity
for CD20 predominantly positivity focally for
CD3 CD5 CD10 CD23 and negativity for cy-
clin-D1 BCL-6 staining was not performed in
our casersquos biopsy Thus according to the IHC
report RLH ALH and follicular lymphoma are
probable diagnosis of our patient
Radiation therapy is the standard treatment for
low-grade OAL that is classified as T1N0M0 or
T2N0M0 according to the AJCC criteria [15]
İncesoy-Ouml zdemir S et al reported a 10-year-old
boy diagnosed of MALT lymphoma who was
treated with local radiotherapy (36 Gy) and
there were no local or systemic recurrences dur-
ing his nearly four-year follow-up [17] Another
case report represented a 21-year-old man of
conjunctival follicular lymphoma treated with
surgical excision only showing no evidence of
recurrence after 8 months follow-up [18] Other
treatment options for pediatric and juvenile OAL
were performed in some case reports including
intravenous rituximab intralesional interfer-
on-α-2b topical interferon a6 systemic doxycy-
cline surgical excision and postoperative local
cryotherapy [15]
Treatment for young conjunctival RLH was less
discussed in the past In a case series article
three children (9 13 14 years old respectively)
of RLH received surgical resection without fur-
ther postoperative management and no signs of
recurrence were noted during follow-up [19]
Short-term topical and oral corticosteroids after
surgical excision were prescribed in two pediat-
ric RLH patients for their small residual mass
However poor response in both cases was nota-
ble [20]
Our patient declined to receive radiotherapy or
any further postoperative treatment mainly due
to his concerning of possible side effects (such
as dry eye and cataract)
CONCLUSION We present a rare case of caruncle mass in this
report OALD is one of the relatively uncommon
diagnosis among caruncular lesions OALD
includes benign RLH and malignant OAL
which are both mainly seen in elderly patients
even rarer in pediatric or juvenile group
The standard treatment for low-grade OAL and
RLH in young patents are still debatable How-
ever long-term follow-up is suggested for both
OAL and RLH patients Though RLH has a be-
nign and self-limited course risk of malignant
transformation is possible
REFERENCES 1 Levy J Ilsar M Deckel Y et al Lesions of
the caruncle a description of 42 cases and
a review of the literature Eye
200923(5)1004-1018
2 C-Y Cheng and W-M Hsu Incidence of
eye cancer in Taiwan an 18-year review
Eye 200418152-158
3 Chui-Lien Tsen Muh-Chiou Lin
Youn-Shen Bee et al Ocular adnexal
lymphoma Five case reports and a
literature review Taiwan Journal of
Ophthalmology 20155(2)99-102
4 Liesegang TJ Ocular adnexal
lymphoproliferative lesions Mayo Clin
Proc 199368(10)1003-1010
5 Kirkegaard MM Coupland SE Prause JU
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
115
et al Malignant lymphoma of the
conjunctiva Surv Ophthalmol
201560(5)444-458
6 Stacy RC Jakobiec FA Schoenfield L et
al Unifocal and multifocal reactive
lymphoid hyperplasia vs follicular
lymphoma of the ocular adnexa Am J
Ophthalmol 2010150(3)412-426
7 Sullivan TJ Ocular Adnexal
Lymphoproliferative Disease In Guthoff
RF Katowitz JA eds Oculoplastics and
Orbit Berlin Heidelberg Springer
20101-19
8 White Valerie A Understanding and
Classification of Ocular Lymphomas
Ocular Oncology and Pathology
20195379-386
9 Stefanovic A Lossos IS Extranodal
marginal zone lymphoma of the ocular
adnexa Blood 2009114(3)501-510
10 Andrew NH Coupland SE Pirbhai A et al
Lymphoid hyperplasia of the orbit and
ocular adnexa A clinical pathologic review
Surv Ophthalmol 201661(6)778-790
11 Ferry JA1 Fung CY Zukerberg L et al
Lymphoma of the ocular adnexa A study
of 353 cases Am J Surg Pathol
200731(2)170-184
12 WM Hassan MS Bakry HM Hassan et al
Incidence of orbital conjunctival and
lacrimal gland malignant tumors in USA
from Surveillance Epidemiology and End
Results 1973-2009 Int J Ophthalmol
20169(12)1808-1813
13 Ajay A Rao John H Naheedy James Y-Y
Chen et al A Clinical Update and
Radiologic Review of Pediatric Orbital
and Ocular Tumors Journal of Oncology
2013(9)975908
14 Sullivan TJ Whitehead K Williamson R
et al Lymphoproliferative disease of the
ocular adnexa a clinical and pathologic
study with statistical analysis of 69
patients Ophthal Plast Reconstr Surg
200521177-188
15 Tanenbaum RE Galor A Dubovy SR et al
Classification diagnosis and management
of conjunctival lymphoma Eye Vis (Lond)
2019622
16 Olga Klavdianou Georgios Kondylis
Vasileios Georgopoulos et al Bilateral
benign reactive lymphoid hyperplasia of
the conjunctiva a case treated with oral
doxycycline and review of the literature
Eye Vis (Lond) 2019626
17 İncesoy-Ouml zdemir S Yuumlksek N Bozkurt C
et al A rare type of cancer in children
extranodal marginal zone B-cell (MALT)
lymphoma of the ocular adnexa Turk J
Pediatr 201456(3)295-298
18 Lynn J Poole Perry Frederick A Jakobiec
Peter A D Rubin Conjunctival Pediatric
Follicular Lymphoma Arch Ophthalmol
2012130(7)941-943
19 Abdullah Al-Mujaini Upender Wali
Anuradha Ganesh1 et al Ocular Adnexal
Reactive Lymphoid Hyperplasia in
Children Middle East Afr J Ophthalmol
201219(4)406-409
20 McLeod SD Edward DP Benign
lymphoid hyperplasia of the conjunctiva in
children Arch Ophthalmol
1999117(6)832-835
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
116
FIGURES
Figure 1 Slit lamp image of a mass lesion at the patientrsquos left eye caruncle for one month
Figure 2 One month after the first excision a protruding mass recurred at the patientrsquos nasal canthus
of left eye It partially involved beyond the gray line of nasal part lower eyelid
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
117
Figure 3 Histomorphology analysis and immunohistochemistry study of the caruncular lesion Abun-
dant atypical lymphoid proliferation presented in low-power photomicrograph (A) and
high-power photomicrograph (B) under hematoxylin-eosin staining The lymphoid aggrega-
tion was composed predominantly of CD20-positive cells (C) and focal positive staining of
CD3 (D)
Figure 4 Non-contrast orbital computed tomography showed a lesion of soft tissue density at medial
canthus of left orbit without obvious nasolacrimal duct or bony invasion (A) Magnetic reso-
nance imaging with contrast showed strong enhancement at left medial canthus region (B)
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
118
Figure 5 The follow-up photo were taken at three months after the second excision showing no signs
of recurrence
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
119
Juvenile Caruncular Atypical Lymphoid Proliferation ndash A Rare Case Report
罕見病例報告mdash青少年之淚阜非典型淋巴增生
施驊瑋 1林友祺 1
中文摘要
淚阜病灶相當罕見大部分為良性病灶眼睛及附屬結構淋巴增生疾病為其
鑑別診斷之一非常少見於年輕人或兒童我們報告一位 16歲的健康男性因
左眼淚阜無痛性腫塊接受切除手術卻於術後一個月復發執行第二次切除手術
後門診追蹤十個月未再復發此案例表現了部分良性與部分惡性腫瘤的特徵
我們針對反應性淋巴增生眼睛及附屬結構淋巴癌兩個疾病做討論及文獻回顧
關鍵字淚阜病灶眼睛及附屬結構淋巴增生疾病眼睛及附屬結構淋巴癌反
應性淋巴增生非典型淋巴增生
1 新光吳火獅紀念醫院眼科
通訊作者林友祺 電子信箱 yuchi067gmailcom
Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh 120
Submitted March 26 2020
Final version accepted April 16
2020
Case Report
Hyperacute intramembranous hemor-
rhage after burr hole craniostomy for
chronic subdural hematoma
Cite as Meng-Chi Lin Jui-Ming
Sun Yu-Hao Chen Cheng-Ta
Hsieh
Hyperacute intramembranous
hemorrhage after burr hole crani-
ostomy for chronic subdural he-
matoma Fu-Jen Journal of Medi-
cine 3(4) 120-125 2020
DOI
103966181020932020091803004
Meng-Chi Lin1 Jui-Ming Sun23 Yu-Hao Chen24 Cheng-Ta
Hsieh567
1Department of Surgery Zuoying Branch Kaohsiung Armed Forces
General Hospital Kaohsiung 813 Taiwan 2Section of Neurosurgery Department of Surgery Chia-Yi Christian
Hospital Chia-Yi City 600 Taiwan 3Department of Biotechnology Asia University Taichung City 41354
Taiwan 4Chung-Jen Junior College of Nursing Health Sciences and Manage-
ment Chia-Yi Country 62241 Taiwan 5Division of Neurosurgery Department of Surgery Sijhih Cathay Gen-
eral Hospital New Taipei City 22174 Taiwan 6Department of Medicine School of Medicine Fu Jen Catholic Univer-
sity New Taipei City 24205 Taiwan 7Department of Neurological Surgery Tri-Service General Hospital
National Defense Medical Center Taipei 114 Taiwan
Corresponding author E-mail address
nogormail2000comtw (Cheng-Ta Hsieh)
ABSTRACT
Burr hole craniostomy with closed-system drainage is an effective and common neurosurgical procedure to manage chronic subdural hematoma Postoperative hem-orrhage a well-known but infrequent complication may result in increased neurolog-ical deficits However hyperacute intramembranous hemorrhage within the inner and outer membrane of hematoma after burr hole craniostomy with irrigation and closed-system drainage has not been described previously Herein we report a case of postoperative spontaneous hyperacute intramembranous hemorrhage after burr hole craniostomy with closed-system drainage to manage a chronic subdural hematoma we subsequently discuss the possible pathophysiological mechanisms and review the relevant literature
Keywords Chronic subdural hematoma acute subdural hematoma bleeding burr hole craniostomy
drainage
Fu-J
Meng
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Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh
125
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
慢性硬腦膜下出血進行鑽顱引流手術造成超急性夾膜內出
血
林孟楫 1孫瑞明 23陳昱豪 24謝政達 567
中文摘要
鑽顱併封閉系統引流手術是治療慢性硬腦膜下出血患者一種有效且常見的
神經外科手術方式術後出血可能導致神經功能缺損惡化是眾所周知但不常見
的併發症之一然而至今仍未有鑽孔併封閉系統引流造成原本慢性硬腦膜血
塊內膜和外膜間急性夾膜間出血案例在這裡我們報告一例慢性硬腦膜下出
血病患者接受鑽顱併封閉系統引流手術治療造成術後急性夾膜間出血我們在
本文中討論可能的致病機制並回顧相關文獻
關鍵字慢性硬腦膜下出血急性硬腦膜下出血出血鑽顱術引流
1國軍高雄總醫院左營分院 外科部
2崇仁醫護管理專科學校
3亞洲大學 生物科技學系
4戴德森醫療財團法人嘉義基督教醫院 外科部 神經外科
5汐止國泰綜合醫院 神經外科
6輔仁大學 醫學系
7 國防醫學院 三軍總醫院 神經外科
通訊作者謝政達 電子信箱 nogormail2000comtw
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
126
Submitted January 21 2020
Final version accepted July 08
2020
Case Report
Hamartoma of the breast A case report
Cite as Hsuan-An Chen
Cheng-Yu Lo Shih-Hung Huang
Chin-Lung Lin
Hamartoma of the breast A case
report Fu-Jen Journal of Medicine
3(5) 126-130 2020
DOI
103966181020932020091803005
Hsuan-An Chen1 Cheng-Yu Lo
3 Shih-Hung Huang
3 Chin-Lung
Lin2
1Department of Surgery Cathay General Hospital Taipei Taiwan
2Department of General Surgery Cathay General Hospital Taipei Tai-
wan
3Department of Pathology Cathay General Hospital Taipei Taiwan
Corresponding author E-mail address
lungyungmailcom (Chin-Lung Lin)
ABSTRACT
Breast hamartoma is an uncommon benign tumor rarely associated with malignancy An
excision and histological examination is necessary for the differential diagnosis We report
a case of a 49-year-old female patient presenting with a lump in the right breast Ultrasound
examination which demonstrated a 4411 cm hypoechoic lesion with lipoma Partial mas-
tectomy was arranged and the diagnosis of a hamartoma was confirmed by the histological
examination
Keywords Breast tumor Hamartoma Ultrasound
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
127
INTRODUCTION The hamartoma is a benign tumor-like lesion
that can affect various organs of the body in-
cluding lungs kidneys skin and more rarely the
breast In 1981 the hamartomas were recognized
in the WHO classification[1] They are defined
as well-demarcated mass of mammary ducts and
lobules containing varying amounts of fibrous
and adipose tissue and producing a distinctive
mammographic image
CASE REPORT A 49 year-old female had past history of left
breast mastitis with abscess status post partial
mastectomy This time she presented to our out
patient clinic for breast examination Physical
examination revealed a painless palpable mova-
ble and painless lump at upper outer quadrant of
right breast The risk of breast cancer was not
noted and the patient did not have any family
history of breast cancer The patient also denied
any trauma history before Ultrasound examina-
tion was arranged which demonstrated a 4411
cm hypoechoic lesion with lipoma at 3 oclock 2
cm from nipple of right breast and multiple hy-
poechoic nodules of various size in both breasts
and there was no suspicious axillary lymph
nodes noted (Figure1) Surgical treatment was
arranged partial mastectomy of right breast
harmartoma was successfully performed A 32 x
31 x 21 cm tumor was completely excised
Grossly examination showed a gray to yellow
and firm to fatty The diagnosis of a hamartoma
was confirmed by the histological examination
Microscopically sections of the breast lesion
show mammary hamartoma composed of ducts
lobules with interlobular fibrous tissue and adi-
pose tissue Fibrocystic change apocrine meta-
plastic ducts and scattered foci of adenosis are
noted The overall lobulocentric architecture and
the 2-cell pattern of the epithelium are preserved
columnar cell change and focal microcalcifica-
tion are present (Figure2) Based on submitted
biopsy specimen in-situ or invasive tumor cells
are not identified
DISCUSSION Hamartoma of the breast is a benign tumor like
nodule it was also known as fibroadenolipoma
lipofibroadenoma or adenolipoma based on its
predominant components It was composed of
varying amounts of glandular adipose and fi-
brous tissue[2] Hamartomas were first described
in 1971 by Arrigoni et al in a study of 10 patients
which breast tumors clinically and grossly re-
sembled fibroadenomas[3]
A higher predominance of tumors exists in fe-
males compared with males Hamartomas are
slowly-growing lesions with the diameter rang-
ing from 2 cm to 5 cm sometimes hamartomas
can reach giant diameter [4]
The clinical diagnosis of hamartoma is based on
the findings from mammography sonography
and histology examinations The hamartomas are
usually incidentally diagnosed by the women
older than 40 year-old starting mammography
screening
On physicial examination harmatomas are usu-
ally occult painless they may be as large mo-
bile soft to firm masses[5] Ultrasound showed
well capsulated mass with echogenic rim and
internal heterogeneity Mammography exam
showed well-circumscribed round to oval
masses containing fat and soft tissue densities
with a thin radiopaque pseudocapsule The
pseudocapsule results from displacement of
breast parenchyma by the tumor [56] In Pa-
thology finding microglandular adenosis is pre-
sent in fibroadipose stroma surrounded by a thin
fibrous capsule It composed of a combination of
epithelial and stromal elements usually with
normal ducts or lobules although variations of
normal tissue may also be seen Fibroadenoli-
poma myoid hamartoma and chondrolipoma are
histological variations of hamartomas depend-
ing on the proportion of normal breast tissue
elements[7]
Malignancy associated with hamartomas are
very rare[8] However it has been reported
hamartomas develop into carcinoma Malignant
transformation can occur as a result of cellular
atypia in the epithelial component of the mass[9]
Surgical removal is the curative method for
breast hamartomas[10] Diagnostic material such
as mammography ultrasonography or core nee-
dle biopsy may not give the definitive diagnosis
Therefore surgical excision and histological
examination is necessary for differential diagno-
sis[111213]
Although it is rare hamartoma can be seen along
with malignancy as it is formed from similar
components of breast tissue Therefore careful
diagnosis and appropriate management including
surgery are required
REFERENCES 1 World Health Organization (1981)
Histological typing of breast tumors In
International histological classification of
tumors 1981 2nd ed
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
128
2 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11435ndash449
2006
3 ArrigoniMG DockertyMB JuddES
The identificationand treatment of
mammary hamartoma Surg Gynecol
Obstet1971 133 577-82
4 Sanal HT Ersoz N Altinel O Unal E Can
C Giant hamartoma of the breast Breast J
2006 12 84-85
5 Feder JM de Paredes ES Hogge JP
Wilken JJ Unusual breast lesions
radiologic-pathologic correlation
Radiographics 1999 19S11ndashS26
6 Murat A Ozdemir H Yildirim H Poyraz
AK Ozercan R Hamartoma of the breast
Australas Radiol 200751 Spec NoB37ndash
9
7 Fisher CJ Hanby AM Robinson L Millis
RR Mammary hamartoma-a review of 35
cases Histopathology 1992 20 99-106
8 Choi N Ko ES Invasive ductal carcinoma
in a mammary hamartoma case report and
review of the literature Korean J Radiol
2010 Nov-Dec11(6)687-91
9 Lee EH Wylie EJ Bourke AG Bastiaan
De Boer W Invasive ductal carcinoma
arising in a breast hamartoma two case
reports and a review of the literature Clin
Radiol 2003 58 80-3
10 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11 435 ‑449
2006
11 Coyne J Hobbs FM Boggis C Harland R
Lobular carcinoma in a mammary
hamartoma J Clin Pathol 199245936ndash
937
12 G M K Tse B K B Law T K F Ma A B W
Chan Hamartoma of the breast a
clinicopathological review J Clin Pathol
200255951ndash954
13 RAAmir SSheikh BreasthamartomaA
report of 14cases of an under-recognized
and under-reported entity International
Journal of Surgery Case Reports
22(2016)1ndash4
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
129
FIGURES
Figure 1 Ultrasound shows a 4411 cm hypoechoic lesion with lipoma at 3 oclock 2 cm from nipple
of right breast
Figure 2 Photomicrograph shows mammary hamartoma composed of ducts lobules with interlobular
fibrous tissue and adipose tissue
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
130
Hamartoma of the breast A case report
乳房錯構瘤罕見個案報告
陳宣安 1羅承裕 3黃世鴻 3林錦龍 2
中文摘要
乳房錯構瘤是一種罕見之乳房良性腫瘤切除手術及病理化驗來做鑑別診斷
我們報告一位 49歲女性以可觸摸到無痛性右側乳房腫塊為臨床表徵超音波
看到一個邊緣清楚低迴音的腫塊病患接受手術切除病灶病理診斷證實為乳
房錯構瘤
關鍵字乳房腫瘤錯構瘤超音波攝影
1國泰綜合醫院外科部
2國泰綜合醫院一般外科
3國泰綜合醫院病理科
通訊作者林錦龍 電子信箱 lungyungmailcom
Fu-Jen Journal of Medicine
Mission and Goals
The Fu-Jen Journal of Medicine (FJJM) is a peer-reviewed journal which
aims to enhance research quality of staffs in the College of Medicine Fu Jen
Catholic University The journal publishes original investigations across a
wide range of medical disciplines including original research articles in basic
and clinical sciences case reports review articles brief reports and letter
to the editor FJJM is now issued by the Center of Medical Education in the
College of Medicine Fu Jen Catholic University To promote journal quality
the manuscript submitted to FJJM after August first 2015 has to be prepared
in English to meet the international standards
Issue Date
Publication Date
Institution
December 01 2003
September 30 2020
College of Medicine Fu Jen Catholic University
Honorable publisher Han-Sun Chiang
Publisher Ping-Keung Yip
Editor-in-chief Ming-Chieh Ma
Associate Editors Yu-Wen Lin
Editors
Telephone (02) 2905-3477
Address Center for Medical Education College of Medicine Fu Jen
Catholic University
No 510 Zhongzheng Rd Xinzhuang Dist New Taipei City
24205 Taiwan
Su-Jane Wang Chi-Chung Wang Chih-Ming Ho
Yih-Jing Lee Chih-Shung Wong Tze-Wah Kao
Chi-Feng Hung Rung-Fen Feng Chee-Fah Chogn
Chia-Chen Lu Zai-Ting Yeh
Dee Pei Chih-Kuang Liu
Hen-Hui Lien Chien-Hsiou Liu
Chun-Hou Liao Yi-Ju Tsai Sheng-Wen Teng
Chia-Ting Su
- 9月封面
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- 2020九月刊排版NO1_完稿
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- 版權頁(SEP)
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Fu-Jen Journal of Medicine Vol 18 No 3 September 2020
CONTENTS
Original Research Article
A Comparison of Remifentanil and Low Dose Fentanyl for Postoperative Recovery
Profile in Patients Undergoing Minimally Invasive Cardiac Surgery
Meng-Chieh Ho Wei-Horng Jean Tzu-Yu Lin Cheng-Wei Lu 89
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 99
Case Report
Juvenile Caruncular Atypical Lymphoid Proliferation ndash A Rare Case Report
Hua-Wei Shih Yu-Chi Lin 112
Hyperacute intramembranous hemorrhage after burr hole craniostomy for chronic
subdural hematoma
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh 120
Hamartoma of the breast A case report
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin 126
Fu-Jen Journal of Medicine Vol 3 No 1 2020
Remifentanil versus fentanyl for MICS
Meng-Chieh Ho Wei-Horng Jean Tzu-Yu Lin Cheng-Wei Lu 89
Submitted October 17 2019
Final version accepted November
01 2019
Original Research Article
A Comparison of Remifentanil and Low
Dose Fentanyl for Postoperative Recovery
Profile in Patients Undergoing Minimally
Invasive Cardiac Surgery
Cite as Meng-Chieh Ho
Wei-Horng Jean Tzu-Yu Lin
Cheng-Wei Lu
A Comparison of Remifentanil
and Low Dose Fentanyl for Post-
operative Recovery Profile in
Patients Undergoing Minimally
Invasive Cardiac Surgery
Fu-Jen Journal of Medicine 3(1)
89-98 2020
DOI
103966181020932020091803001
Meng-Chieh Ho1 Wei-Horng Jean12 Tzu-Yu Lin12 Cheng-Wei
Lu12
1Department of Anesthesiology Far Eastern Memorial Hospital Ban-
qiao Dist New Taipei City Taiwan 220 2Department of Mechanical Engineering Yuan Ze University Taoyuan
Taiwan 320 Contributed equally
Corresponding author E-mail address
drluchengweigmailcom (Cheng-Wei Lu)
ABSTRACT
Background The concept of enhanced recovery after surgery (ERAS) is flourishing in multiple specialties including cardiac surgery Beside minimally invasive surgical ap-proach short acting anesthetic agent is one of the major components of ERAS programs Remifentanil is an ultrashort acting opioid agent The purpose of this study was to compare remifentanil and low dose fentanyl for postoperative recovery profile in patients undergoing minimally invasive cardiac surgery (MICS) Methods This study was a retrospective study We compared the recovery profile including extubation time after surgery length of hospi-tal stay postoperative morphine consumption pain scores and in hospital complication rate between patients undergoing elective MICS from May to August 2018 Results Fifty-three patients were enrolled in this study 33 of them were in group remifentanil (G remifentanil) and 20 were in group fentanyl (G fentanyl) The extubation times average hospital stay postoperative morphine consumption pain scores and in hospital complication rate were all similar between both groups Conclusion We consider remifentanil can be safely used in MICS and provides similar recovery profile as low dose fentanyl
Keywords minimally invasive cardiac surgery enhanced recovery after surgery opioids
Fu-J
Meng
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ance recovery urgery (MICSvery time w
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mifentanil an pioid receptorspecific esteraaccumulate afpharmaceuticasidered as safey [8] Howeveng a fast-trackersial results ective study tsafety of remi
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pt includes fis from 18 to 8MICS betweeents with a hientanyl pregnsing medical ents were moe oximetry a
metry cerebraectral index (
al echocardiopharyngeal temiratory and e
xide and sevnitored and reed with midakg of the bod
and rocuronght A doubled to provide oration The pups Patients ie induced withght and receivbody weight a
of Medicine V
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CTION nhanced recovng popularity acheal extubat
cardiac surgovery and to
ve care unit (ICapproach is a[1] Minimal
S) is proven with recovery onventional sut of ERAS prort acting aneultra-short a
r agonist is ase [7] and fter prolongedal properties
fe and effectiver applicatiok cardiac surg[9-11] We coto investigateifentanil in paetermine wherecovery
LS AND Me study reportifty-three pat80 years) whoen May 2018 istory of allergnant women
records weronitored with
arterial and ceal near-infrar(BIS) monitorography (TEmperature re
expiratory oxyvoflurane conecorded All azolam 25 mdy weight denium 1 mge lumen endotone-lung ventatients were in group fentah fentanyl 5 μ
ved bolus doseas required du
Vol 3 No 1 2
Remifentani
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very after surin multiple
tion is commgery to enhreduce the leCU) A minimanother metholly invasive cato have a shooutcomes onurgeries [2-5ograms is thesthetic agent
acting and pometabolized
therefore it d infusion Du remifentani
ve for cardiac n of remifengery yielded onducted thisthe effective
atients undergether remifen
METHODted in this mtients (rangingo underwent eand August 2gy to remifenand patients re excluded h a 5-lead Eentral venous red spectroscr and transesoE) In addiectal temperaygen and carncentrations wpatients weremg etomidatexamethasonekg of the btracheal tube tilation duringdivided into
anyl (G fentaμgkg of the bes of 1-2 μgk
uring the opera
2020
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rgery spe-
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anyl) body kg of ation
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1-5 μgkgh thwas maintaintration requirween 40 and s managed bydose and gas basis of TEE
ue Inotropes ed in cases whnagement of
milarly intraopd by adjustintration folloardipine or ni
dotracheal tubmen endotrach
immediate pnts were admne thirty mingery For posnts were ant-controlled ahe ICU unders morphine 1kout time of 1ml The mormerical scaleorded every 8tion Anesthesed anesthesiosthesia Extubording to a wpatients were
transferred oumes of this stugery and mortive days 1 2
mes included hy pain scorestoperative dayuired compliuired complic
urs and the 3ed For statis
meters were dviation and weegorical paramand were comrphine consu
noted as meding Mann-Whip = 005 was s
p remifentanilth remifentanand received mhroughout thened by sevoflured to mainta
60 Intraopery fluid supplem
concentrationE findings CV
and vasopreshere other methe intraopera
perative hyperg the opioid owed by aitroglycerin T
be was replacheal tube at thpostoperative
ministered withnutes prior to toperative padministered
analgesia (PCAr sedation Re mgml and b
10 minutes anrphine consume 0-10) and 8 hours for 5 sia was adminologists specbation was perweaning protoe stabilized thut of the ICUudy were extrphine consum
2 3 and 5 Thospital stay s at rest and ys 1 2 3 anications Instacations and r30-day mortalstical analysidenoted as mere compared
meters were dmpared using Fumption and an and quartitney U test Aet for all statis
il (G remifennil 05-10 μgmaintenance d
e surgery Aneurane with aain the BIS rative hypotement and then were adjusteVC level andssor were admethods failed irative hypotenrtension was dose and gasadministrationThe double luced with a she end of suranalgesia al
h 10 mg of the conclusio
ain control alintravenous
A) and transfegimen of IV bolus 1 ml w
nd a 4-hour limmption pain
side effects days after th
nistered by excialized in carformed in theocol (Fig1) they were rea The primarytubation time mption on po
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nd 5 and hoances of hore-operation ility rate wereis continuous
mean and stand using t-test wdenoted as freqFisherrsquos exactpain score
iles and compA significance stical tests
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n comorbiditieertension and elated and othed in Table 1)47 hours for
ifentanil whil355 hours f
G remifentannary bypass wmp time was 6
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nts were enrolinto the two
20 patients (1years p=0104d of 33 patiees ~ 58 yearsn G fentanyl aunderwent vales across both
diabetes meher demograp The mean anG fentanyl a
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Vol 3 No 1 2
Remifentani
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lled in this sgroups G fe
3 male 7 fem4) while G rents (15 male p = 0104) and 25 patienve surgery C
h groups inclullitus (comorbphic data arenesthesia duraand 5 hours fouration of suryl and 375 hwhere cardio
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in G remifenentanil The aration and cgroups were Table 3 tim
d 1496 hours respectively
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s The rate of was 30 in
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due to bleent in G remi
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tanyl was
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ng the extubatCS Previous t difference eiving remifese receiving logery [12] Othuced extubatiored remifentared sufentanults may be dy agents anding strategy mns The extubaoperative lune fluid manageon manageme
milar lung comnagement In s applied to aitment was pe
ntilation Thests of confoungested that thsubtler the d
s research ree with remife
mifentanil mayeshold level ients includedthe ICU accowever the stacretion of ICUy be prolonge Previous re
mediate extuber cardiac surgat the discretiogists [14] Thy have been ne owing to thee ERAS progdical costs anources Howeshorten the h
U Engoren etated similar lenU in patientstanyl [915] Tncreased costdiac surgery gram consistsaoperative ahlights key ce risk assessmeucation prehrapy multimoin removal an
tion time in presearch has
in extubationentanil infusiow dose fenta
her studies shoon time amonnil as oppose
nil [1013] Tattributable t
d populations may also lead ation time mayg disease smement and inent However
morbidity and paddition pro
all patients anerformed at thse measures mnding factors he longer the
difference betweports an incentanil howey have beenand thus wa
d in this researording to a wart of the weaU physicians ed to allow thesearch has
bation can be gery if the exon of the supehe extubation shortened hoe current hosp
gram was estand improve uver the use o
hospital stay ot al and Chength of stays s administereThe use of rems [9] The ERwere recentl
s of three staand postoperaomponents inent patient ophabilitation odal analgesiand ambulation
patients underg found no sig
n time in paion compare
anyl during caowed evidenceng patients aded to those adThese conflito a differen A variable oto diverse co
ay be influencemoking periontraoperative vr our patientsperioperative
otective ventilnd manual lunhe end of oneminimized thA previous
e ventilation ween groups creased extubever the effen lower thanas undetectedrch were extuweaning protaning is up t
s and the weahe patient to demonstrated
e performed sxtubation startervising anesttime in our
owever it wapital policies ablished to reutilization of of remifentanior length of steng et al dein the hospita
ed remifentanmifentanil als
RAS guidelinely publishedages preoperative Each ncluding preoptimization pagoal-direct
a early extuban [16] William
91
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successfully absequent impropital and ICU tion [17] Leduced extub
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the short g property ofpostoperative een the two grralgesia wereat remifentaniative pain afte
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dered to be eqMICS ions to this srospective napotential bias
y have influenes between theof remifentanby the lack oThe results masurgeries as onhis study
ION ed to demonsver low dose n and reducedCU among paperative morpith remifentanfter administrasult remifenta
used in MICSquired to detetients undergo
CES Lamelas J Door minimallycritical reviewfic information
Vol 3 No 1 2
Remifentani
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applied the ERovement in leand postopera
Li et al furbation time anmplementatione we theorizeective rather oid [1019] rate a signifi
ve morphine Previous resestoperative opan intraoperaThis anomal
half-life f remifentanilpain scores wroups Further recorded Hoil does not leaer cardiac surwere rare andlications was As a result r
qually safe as
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nil may have bof a standarday not generanly elective M
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nil were similaation of low anil can be saS Research ermine the roloing MICS
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2
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cardiovascuDieberg Ginvasive creview anjournal of cGrant SWPropensity-invasive apmitral vaCardiac SoHolmes SDet al HealtMinimally Innovations20161112Rabindranaal Minimbypass gimproved (PhiladelphWong WTFast-track surgical paRev 20169Westmorelaal Pharm(GI87084B(GI90291) inpatient 19937989Michelsen The pharmpatients ungrafting wAnesthesia Engoren Mcomparisonremifentanianesthesia 20019385Lison S Scardiac aneremifentanicardiothora20072135Mollhoff Tal Comparemifentanicoronary arandomizedjournal of aKhanykin BComparisofentanyl foprospectivesurgery forZakhary W
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Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang
99
Submitted October 11 2019
Final version accepted February
02 2020
Original Research Article
Human Factors Underlying Adverse
Medical Events Revisit Root Cause Anal-
ysis Cases Using the HFACS
Cite as Yu-Hsun Cheng
Sheng-Hui Hung Tung-Wen Ko
Pa-Chun Wang
Human Factors Underlying Ad-
verse Medical Events Revisit
Root Cause Analysis Cases Using
the HFACS Fu-Jen Journal of
Medicine 3(2) 99-111 2020
DOI
103966181020932020091803002
Yu-Hsun Cheng1 Sheng-Hui Hung
12 Tung-Wen Ko
3 Pa-Chun
Wang14
1Department of Quality Management Cathay General Hospital Taipei
Taiwan
2Institute of Health Policy and Management National Taiwan Universi-
ty Taipei Taiwan
3Center for Healthcare Quality Management Cheng Hsin General Hos-
pital Taipei Taiwan
4Fu Jen Catholic University School of Medicine New Taipei City Tai-
wan
Corresponding author E-mail address
drtonyseednettw (Pa-Chun Wang)
ABSTRACT Background Appropriate management of adverse medical events (AMEs) is the corner-
stone of patient safety Root cause analysis (RCA) is used to investigate serious or
high-frequency errors but is limited by its inability to explain a broader scope of factors
We re-reviewed RCA cases to understand the underlying human organizational or system-
ic factors affecting AMEs Methods A total of 40 consecutive RCA cases (2012-2016) were
retrieved from the AMEs database A panel was organized to retrospectively re-review these
cases using the Human Factor Analysis and Classification System HFACS Results For
active failures errors stemmed largely from performance-based (95) judgment and deci-
sion-making errors (875) Incorrectly followed procedures (816) and accidental
equipment operation (50) were the most common types of performance-based errors In-
adequate real-time assessment (686) and inappropriate operative actions (686) were
the most common decision-making errors For sources of latent failure teamwork problems
(275) including failure to effectively communicate (818) and communicate critical
information (727) were common Inadequate supervision (929) or command over-
sights (929) were the most common problems related to inadequate supervision (35)
Organizational programpolicy risks not adequately assessed (50) were the most common
problems related to policy and process problem (25) Conclusions The HFACS review
enhances our understanding of human factors underlying AMEs The HFACS reveals latent
supervisory organizational or systematic problems that cannot be addressed through tradi-
tional RCA Keywords patient safety adverse events root cause analysis human factors
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 100
INTRODUCTION Patient safety involves the reduction of patient
harm from potentially avoidable unintended
outcomes [1] Studies have revealed that 50ndash
80 of adverse medical events (AMEs) are pre-
ventable [2-4] to eliminate such errors the ap-
propriate management of AMEs hence repre-
sents the cornerstone of patient safety work
Through incident reporting investigation and
analysis healthcare providers can correct or
re-engineer their care processes to prevent inci-
dent recurrence [25] One of the most popular
tools for investigating AMEs is root cause anal-
ysis (RCA) RCA reconstructs a chain of errors
to identify the deviation of care from normal
processes Nonetheless with a lack of standard-
ized nomenclature and investigation procedures
RCA report conclusions are sometimes too sub-
jective and nonspecific to facilitate any actiona-
ble safety improvement plans [5-7] According
to the UK Health and Safety Executive defini-
tion human factors are environmental organiza-
tional occupational or individual human char-
acteristics which influence behavior at work
such that health and safety are affected [8] Hu-
mans and systems are prone to errors and stud-
ies have showed that nearly 70 of medical
errors involve human factors [2-4] Reasonrsquos
Swiss cheese model described the penetration of
causative human errors through layers of defen-
sive barriers leading to system collapse [9]
With much focus on the temporal sequence and
severity of departure from accepted practices in
an incident the effectiveness of RCA is often
challenged by its incapability of exploring un-
derlying human organization or even systemic
factors [5-7] Reason and others have proposed
that errors can occur at 4 levels 1) unsafe acts
(operator actions) 2) preconditions for unsafe
acts (environmental factors contributing to er-
rors) 3) inadequate supervision (management
actions affecting the operator) and 4) organiza-
tional influences (organizational culture policies
and procedures that affect the operator) [9]
Based on this theory Wiegmann and Shappell
developed the Human Factor Analysis Classifi-
cation System (HFACS) to describe human fac-
tors causing accidents from 4 tiers of categories
Each of these categories consists of nanocodes to
represent specific human behavior or system
problems leading to errors [9-10] The tier for
unsafe acts involves actual provider actions (er-
rors or rule violations) directly leading to events
The tier representing preconditions for unsafe
acts includes operational personnel and envi-
ronmental factors The supervision tier addresses
leadership problems operational planning fail-
ure or correction and supervisory ethics The
tier for organizational influences deals with re-
source management organizational climate and
operational processes (Supplement Table 1) The
HFACS provides standardized investigation
processes for the systematic analysis of common
causes of adverse events across national defense
nuclear power navy aviation and healthcare
industries Taiwan launched its nationwide
AME-reporting system the Taiwan Patient
Safety Reporting System (TPR) in 2004 RCA
methodology was subsequently introduced to the
healthcare industry by the Joint Commission of
Taiwan [11] Since 2012 appropriate manage-
ment of AMEs has been listed as a national pa-
tient safety goal [12] RCA is required by the
Ministry of Health and Welfare for major AMEs
Aside from RCA a comprehensive structural
reliable and valid framework is urgently re-
quired to further guide organizational or even
national patient safety policies In this study we
used the HFACS to review our RCA cases aim-
ing to investigate human factors underlying se-
vere or frequent AMEs
MATERIALS AND METHODS Through continuous sampling 40 consecutive
RCA cases (2012-2016) were retrieved from a
hospitalrsquos (Cathay General Hospital Taipei
Taiwan) AME-reporting system database The
database contains AMEs relating to areas such as
medication patient falls surgery transfusion
clinical care public accidents security hospital
violence tube-related complication unplanned
cardiopulmonary resuscitation laboratory testing
and examination and anesthesia The RCA cases
were sentinel or high-frequency events classified
according to severity assessment category (SAC)
[1113] The SAC is an evaluation method for
categorizing AMEs by severity of effect on pa-
tients health and risk of incident reoccurrence
The HFACS has been modified (from the US
Department of Defense version 70) and trans-
lated into Mandarin Chinese with authorization
from the original developers [10] The Chi-
nese-version HFACS for Taiwan is a valid in-
strument (content validity index 09 Cronbachrsquos
α gt07 interrater reliability Κ 04-10) equiva-
lent to the original English version [9] The
HFACS contains 4 tiers 13 subitems and 109
nanocodes (Supplement Table 1) A panel of 6
reviewers was established All reviewers were
from clinical or management (quality and patient
safety management) backgrounds Reviewers all
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 101
finished human factor education and were
trained to use the HFACS through a consensus
meeting Each RCA case was randomly assigned
to 2 reviewers Human factors leading to partic-
ular AMEs were identified and confirmed when
2 reviewers reached agreement The distribution
of errors among tiers subitems and nanocodes
are provided with descriptive statistics () The
study was approved by the Institutional Review
Board of Cathay General Hospital
(CGH-P105095)
RESULTS AMEs related to laboratory testing and examina-
tion (n = 16) clinical care (n = 9) and medica-
tion (n = 7) were the most commonly observed
in the RCA Most AMEs in this cohort are
ranked as being SAC level 3 (n = 15) or 4 (n =
17) (Table 1)
Acts (Active Failures)
This tier of errors contains 3 subitems and 13
nanocodes In the 40 RCA cases perfor-
mance-based errors for 38 (95) and judgment
and decision-making errors for 35 (875) com-
prised the most common error types with viola-
tion for 6 (15) less common Procedure fol-
lowed incorrectly for 31 out of 38 (816) was
the most common performance-based problem
Inadequate real-time risk management for 24 out
of 35 (686) was the most common judgment
or decision error All of the rule violations were
workaround types for 6 out of 6 (100) (Figure
1)
Preconditions(Latent Failures)
This tier of errors has 9 subitems and 58 nano-
codes In the 40 RCA cases teamwork for 11
(275) and environmental for 8 (20) factors
contributed to most of the errors with mental
and physical state the next most common factor
for 7 (175) Communication for 9 out of 11
(818) and information relay for 8 out of 11
(727) were the most common issues related to
teamwork Few contributors mentioned failures
related to technical errors for 4 (50) or physi-
cal for 1 (125) environment Not paying at-
tention for 4 out of 7 (571) and negative habit
transfer for 4 out of 7 (571) were common
mental contributes noted for 7 (100) Overcon-
fidence was the most common problem related
to emotional status for 4 out of 7 (571) Fa-
tigue was observed in only 2 cases for 2 out of 2
physical problems (100) (Figure 2)
Supervision(Direct Supervisory Chain of
Command)
This tier of errors contains 3 subitems and 17
nanocodes In the 40 RCA cases inadequate
supervision for 14 (35) and inappropriately
planned operations for 11 (275) factors con-
tributed to most of the respective errors fol-
lowed by supervisory violations for 7 (175)
Supervisory or command oversights for 13 out
of 14 (929) were the most common sources of
supervision inadequacy Authorized unnecessary
hazards for 7 out of 11 (636) were the most
common inappropriately planned operations
Failure to enforce rules for 6 out of 7 (857)
was the most common supervisory violation
(Figure 3)
Organization Influence (Upper-Level Man-
agement)
This tier of errors contains 4 subitems and 18
nanocodes In the 40 RCA cases policy and
process issues for 10 (25) and resources prob-
lem for 8 (20) were major concerns Few of
the respective problems are related to climate
and cultural influences for 2 (5) or to person-
nel selection and staffing for 1 (25) Poorly
assessed organizational programs or policy risks
for 5 out of 10 (50) were the most common
policy and process problems Failure to provide
adequate operational information resources for 4
out of 8 (50) and command and control re-
source deficiency for 3 out of 8 (375) were
the main resource management problems Little
was revealed regarding organizational climate
and culture (n = 1 out of 2 50) or staffing for 1
out of 1 (100) (Figure 4)
DISCUSSION Health care is a complex system comprising
many high-reliability organizations (HROs) The
vulnerability of HROs stems from the participa-
tion of multidisciplinary teams in the processes
along a variety of patient care timelines How-
ever humans and systems are inherently prone
to errors the appropriate management of AMEs
is acknowledged to be the cornerstone of patient
safety AMEs should be reported investigated
analyzed and handled appropriately[14] Theo-
retically by analyzing the pattern of key defects
providers can fix errors and re-engineer their
care processes to reduce the possibility of AME
recurrence Taiwan established its nationwide
TPR in 2004 so far 7000 health care facilities
have participated and the database has accumu-
lated more than 055 million AMEs[11] Infor-
mation generated from the TPR database can
improve patient safety at individual organiza-
tional or even national levels However despite
relentless efforts few substantial improvements
have been achieved in patient safety [15-17]
Since its introduction in Taiwan in 2006 the use
of RCA for AMEs has encountered some diffi-
culties 1) No structural and standardized
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 102
framework exists for investigation
cross-institution variability and interrater relia-
bility are often ignored 2) Conclusions are often
subjective and corrective recommendations are
less actionable relying on individual reviewersrsquo
professional backgrounds and their experiences
3) Much focus on event reconstruction and oper-
ator performance means that factors relating to
human behavior organizational culture and
system weakness are not comprehensively ad-
dressed [671718] Traditionally attempts to
improve patient safety in the health care industry
are largely reactive in nature identifying and
correcting errors in care processes [1920]
Causes of defects are not thoroughly understood
Proactive approaches must be taken to address
systematic problems within a complex system
[720] Research suggests that human error is a
causal factor in the occurrence of AMEs AME
investigation targets have moved from skill defi-
ciency toward decision-making attitudes super-
visory factors and even organizational climate
or culture HFACS methodology is based on the
Swiss cheese model that also emphasizes active
and latent failures [921] The study provides
some noteworthy findings First most AMEs as
expected involve active failures such as failure
to follow procedure accidental operation of
equipment inadequate real-time risk manage-
ment and inappropriate action These are all
sharp ends in classic RCA environment physi-
cal and mental factors are less prevalent This
proves that retrospectively determining addi-
tional causal factors is difficult when infor-
mation has not been collected during preliminary
investigation (Figure 1) Second team-
work-related problems particularly in relation to
communication and information relay are well
addressed This may be attributed to the dec-
ade-long institution-wide routine crew resource
management training in the respective research
hospital (Figure 2) Third the HFACS success-
fully reflects the importance of supervisory roles
in the occurrence of AMEs and this cannot be
overlooked (Figure 3) Fourth latent failures
especially in organizational climate or cultural
dimensions have been less frequently addressed
in incident reports a limitation of traditional
RCA However the HFACS review suggests
room for improvement in resource allocation and
policy modification within the hospital The
results of studies can make the organization
think about how to improve the patient safety
and management process from the perspective of
human factors such as improving the comfort of
the working environment and replacing and
equipment resources to prevent personnel from
affecting the medical quality and patient safety
due to the environment or equipment Need to
appropriate assessment of applicability and ade-
quate training of manpower is required The
management and control of risks should be fully
evaluate and grasp resource management and
leaders need to participate in and promote medi-
cal quality and patient safety activities to en-
hance its culture (Figure 4) No panacea exists
to ensure patient safety and improvement targets
originate largely from event investigation find-
ings Unfortunately factors identified from
AMEs are often self-explanatory with little value
for further action correction Reinforcement of
policy or processes redundant education or
repetitious training are formulaic overprescribed
RCA recommendations The use of HFACS in
this study proves that a structural prospective
AME investigation format can potentially help
with proactive patient safety management We
suggest developing an interview guideline for
the routine use of HFACS as a complement to
RCA in every AME investigation This study is a
retrospective study The underlying human fac-
tors can be under-estimated owing to the lack of
related information in the original RCA reports
CONCLUSION The HFACS review in this study enhances our
understanding of human factors in AMEs that
had previously been insufficiently scrutinized
Aside from active process and communication
errors the HFACS enables the prospective in-
vestigation of latent supervisory organizational
or systematic problems that cannot be addressed
through traditional RCA
REFERENCES 1 T Brennan L Leape N Laird et al
Incidence of adverse events and
negligence in hospitalized patients results
of the Harvard Medical Practice Study I N
Engl J Med 1991324370-376
2 Wang CH Shih CL Chen WJ et al
Epidemiology of medical adverse events
perspectives from a single institute in
Taiwan J Formos Med Assoc
2016115434-439
3 Vincent C Simon R Sutcliffe K et al
Errors Conference Executive Summary
Acad Emerg Med 200071180-1182
4 Taitz J Genn K Brooks V et al
System-wide learning from root cause
analysis A report from the New South
Wales Root Cause Analysis Review
Committee Qual Saf Health Care
2010191-5
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 103
5 Hutchinson A Young TA Cooper KL et
al Trends in healthcare incident reporting
and relationship to safety and quality data
in acute hospitals results from the
National Reporting and Learning System
Qual Saf Health Care 2009185-10
6 Mitchell RJ Williamson AM Molesworth
B et al A review of the use of human
factors classification frameworks that
identify causal factors for adverse events
in the hospital setting Ergonomics
2014571443-1472
7 Gurses AP Ozok AA Pronovost PJ Time
to accelerate integration of human factors
and ergonomics in patient safety BMJ
Qual Saf 201221347-351
8 Health and Safety Executive Introduction
to human factors
httpwwwhsegovukhumanfactorsintro
ductionhtm
9 Wiegmann DA Shappell SA A human
error approach to aviation accident
analysis The human factors analysis and
classification system Burlington VT
Ashgate Publishing Ltd 2003
10 Yu-Hsun Cheng Sheng-Hui Hung
Tung-Wen Ko et al An Analysis of the
Reliability and Validity of Human Factors
Analysis Classification System in Medical
Adverse Events Journal of Healthcare
Quality 20191370-76
11 Taiwan Joint Commission on Hospital
Accreditation Taiwan Patient-Safety
Reporting System Annual Report 2017
New Taipei City Taiwan
12 Taiwan Patient Safety Net
httpwwwpatientsafetymohwgovtwCo
ntentzMessagesslistaspxSiteID=1ampMm
mID=621273300317401756
13 Government of Western Australia
Department of Health
httpsww2healthwagovauArticlesS_T
Severity-assessment-codes
14 Farley DO Haviland A Champagne S et
al Adverse-event-reporting practices by
US hospitals results of a national survey
Qual Saf Health Care 200817416-423
15 Shojania KG Thomas EJ Trends in
adverse events over time why are we not
improving BMJ Qual Saf
201322273-277
16 Levitt P Challenging the systems approach
why adverse event rates are not improving
BMJ Qual Saf 2014231051-1052
17 Kellogg KM Hettinger Z Shah M et al
Our current approach to root cause
analysis is it contributing to our failure to
improve patient safety BMJ Qual Saf
201726381-387
18 Khorsandi M Skouras C Beatson K et al
Quality review of an adverse incident
reporting system and root cause analysis of
serious adverse surgical incidents in a
teaching hospital of Scotland Patient Saf
Surg 2012621
19 Diller T Helmrich G Dunning S et al
The Human Factors Analysis
Classification System (HFACS) Applied to
Health Care Am J Med Qual
201429181-190
20 Carayon P Xie A Kianfar S Human
factors and ergonomics as a patient safety
practice BMJ Qual Saf 201423196-205
21 Reason J Human Error New York
Cambridge University Press 1990
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 104
TABLE
Table 1 Incidences by Category (N=40)
CategorySAC SAC 4 SAC 3 SAC 2 SAC 1 total
Laboratory and ex-
amination events
4 10 2 0 16 (400)
Clinical care event 6 2 1 0 9 (225)
Medication event 5 0 2 0 7 (175)
Surgery-related event 1 1 2 0 4 (100)
Transfusion-related
event
1 1 0 0 2 (50)
Tube event 0 1 0 0 1 (25)
Public accident 0 0 1 0 1 (26)
Total 17 (425) 15 (375) 8 (200) 0 40 (100)
SAC 1113 Severity Assessment Code SAC
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 105
FIGURES
Figure 1 Active Failures (N=40)
16 (167)
66 (1000)
640 (150)
235 (57)
735 (200)
2435 (686)
2435 (686)
3540 (875)
438 (105)
438 (105)
738 (184)
1938 (500)
3138 (816)
3840 (950)
0 5 10 15 20 25 30 35 40
Commits WidespreadRoutine Violation
Performs Work-Around Violation
Ignored a CautionWarning
Failure to Prioritize Tasks Adequately
Wrong Choice of Action During an Operation
Inadequate Real‐Time Risk Assessment
Rushed or Delayed a Necessary Action
Breakdown in Visual Scan
Over-ControlledUnder-Controlled AircraftVehicleSystem
Unintended Operation of Equipment
Procedure Not Followed Correctly
Performance-Based Errors
Judgment and Decision Making Errors
Violations
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 106
Figure 2 Preconditions (Latent Failures or Conditions) (N=40)
14 (250)
24 (500)
48 (500)
11 (1000)
18 (125)
840 (200)
0 5 10 15 20 25 30 35 40
Seat and Restraint System Problems
Instrumentation amp Warning System Issues
Noise Interference
Environment
Physical Environment
Technological Environment
27 (286)
27 (286)
27 (286)
37 (129)
47 (511)
47 (571)
77 (1000)
24 (500)
44 (1000)
47 (571)
12 (500)
22 (1000)
27 (286)
740 (175)
0 5 10 15 20 25 30 35 40
Technical or Procedural Knowledge Not Retained After Training
InterferenceInterruption
Task OverUnder Saturation
Distraction
Negative Habit Transfer
Not Paying Attention
Complacency
Overconfidence
Physical IllnessInjury
Fatigue
Physical and Mental State
Physical Problem
State of Mind
Mental Awareness
211 (182)
311 (273)
311 (273)
411 (364)
811 (7227)
911 (818)
1140 (275)
0 5 10 15 20 25 30 35 40
Inadequate Task Delegation
TaskMission PlanningBriefingDebriefing Inadequate
Failure of CrewTeam Leadership
StandardProper Terminology Not Used
Critical Information Not Communicated
Failed to Effectively Communicate
Teamwork
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 107
Figure 3 Supervision (Direct Supervisory Chain of Command) (N=40)
Figure 4 Organization Influence (Upper-Level Management Command Level) (N=40)
114 (71)
114 (71)
214 (143)
314 (214)
1314 (929)
1440 (350)
511 (455)
511 (455)
711 (636)
1140 (275)
47 (571)
67 (857)
740 (175)
0 5 10 15 20 25 30 35 40
Selected Individual with Lack of Proficiency
Improper Role‐modeling
Failed to Provide Proper Training
Failed to IdentifyCorrect Risky or Unsafe Practices
SupervisoryCommand Oversight Inadequate
Performed Inadequate Risk Assessment ‐Formal
Selected Individual with Lack of Current or Limited Experience
Authorized Unnecessary Hazard
Allowing Unwritten Policies to Become Standard
Failure to Enforce Existing Rules
Supervisory Violations
Planned Inappropriate Operations
Inadequate Supervision
12 (500)
12 (500)
240 (50)
110 (100)
510 (500)
1040 (250)
11 (1000)
140 (25)
18 (125)
18 (125)
38 (35)
48 (500)
840 (200)
0 5 10 15 20 25 30 35 40
Organizational Over-confidence or Under-confidence in Equipment
Organizational Culture (attitude actions) Allows for Unsafe TaskMission
Purchasing or Providing Poorly Designed or Unsuitable Equipment
Organizational ProgramPolicy Risks not Adequately Assessed
Failure to Provide Adequate Manning Staffing Resources
Failure to remove inadequate worn-out equipment in timely manner
Inadequate infrastructure
Command and control resources are deficient
Failure to provide adequate operational information resources
Resource Problems
Personnel Selection amp Staffing
Policy and Process Issues
ClimateCulture Influences
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 108
Supplement Table 1- HFACS Content of Human Factor Analysis Classifi-
cation System [9] Tier main level sub-item nano code
Tier 1 Unsafe Acts
Perfor-
mance-Based
Errors
Unintended operation of equipment
Checklist not followed correctly
Procedure not followed correctly
Over-controlledunder-controlled aircraftvehiclesystem
Breakdown in visual scan
Rushed or delayed a necessary action
Judgment amp De-
cision-Making
Errors
Inadequate real‐time risk assessment
Failure to prioritize tasks adequately
Ignored a cautionwarning
Wrong choice of action during an operation
Violations
Performs work-around violation
Commits widespreadroutine violation
Extreme violation-lack of discipline
Tier 2 Preconditions
Environment
Physical environment
Environmental conditions affecting vision
Vibration effects vision or balance
Heatcold stress impairs performance
External force of object impeded an individualrsquos
movement
Lights of other vehiclevesselaircraft affected vision
Noise interference
Technological environment
Seat and restraint system problems
Instrumentation amp warning system issues
Visibility restrictions (not weather related)
Controls and switches are inadequate
Automated system creates unsafe situation
Workspace incompatible with operation
Personal equipment interference
Communication equipment inadequate
Physical and
Mental State
Physical problem
Substance effects (alcohol supplements medications
drugs)
Loss of consciousness (sudden or prolonged onset)
Physical illnessinjury
Fatigue
Inadequate adaptation to darkness
Dehydration
Body sizemovement limitations
Physical strength amp coordination (inappropriate for
task demands)
Nutritiondiet
State of mind
Psychological problem
Life stressors
Emotional state
Personality style
Overconfidence
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 109
Pressing
Complacency
Motivation
Motivational exhaustion (burnout)
Sensory misperception
Motion illusion-kinesthetic
Turning illusionbalance-vestibular
Visual illusion
Misperception of changing environment
Misinterpreted misread instrument
Misinterpretation of auditorysound cues
Spatial disorientation
Temporaltime distortion
Mental awareness
Not paying attention
Fixation
Task overunder saturation
Confusion
Negative habit transfer
Distraction
Geographically lost
Interferenceinterruption
Technical or procedural knowledge not retained after
training
Inaccurate expectation
Teamwork
Failure of crewteam leadership
Inadequate task delegation
Rankposition intimidation
Lack of assertiveness
Critical information not communicated
Standardproper terminology not used
Failed to effectively communicate
Taskmission planningbriefingdebriefing inadequate
Tier 3 Supervision
Supervisory Vio-
lations
Failure to enforce existing rules
Allowing unwritten policies to become standard
Directed individual to violate existing regulations
Authorized unqualified individuals for task
Planned Inappro-
priate Operations
Directed task beyond personnel capabilities
Inappropriate team composition
Selected individual with lack of current or limited experience
Performed inadequate risk assessment ‐formal
Authorized unnecessary hazard
Inadequate Su-
pervision
Supervisorycommand oversight inadequate
Improper role‐modeling
Failed to provide proper training
Failed to provide appropriate policyguidance
Personality conflict with supervisor
Lack of supervisory responses to critical information
Failed to identifycorrect risky or unsafe practices
Selected individual with lack of proficiency
Tier 4 Organizational
Influences
Resource Prob-
lems
Command and control resources are deficient
Inadequate infrastructure
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 110
Failure to remove inadequate worn-out equipment in timely
manner
Failure to provide adequate operational information resources
Fail to provide adequate funding
Personnel Selec-
tion amp Staffing
Personnel recruiting amp selection policies are inadequate
Failure to provide adequate manning staffing resources
Policy amp Process
Issues
Pace of ops-tempoworkload
Organizational programpolicy risks not adequately assessed
Provided inadequate procedural guidance or publications
Organizational (formal) training is inadequate or unavailable
Flawed doctrinephilosophy
Inadequate program management
Purchasing or providing poorly designed or unsuitable equip-
ment
ClimateCulture
Influences
Organizational culture (attitude actions) allows for unsafe
taskmission
Organizational over-confidence or under-confidence in equip-
ment
Unit missionaircraftvehicleequipment change or unit deacti-
vation
Organizational structure is unclear or inadequate
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 111
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
以 HFACS重新檢視根本原因分析案例挖掘造成醫療不良
事件之人為因素
鄭伃洵 1洪聖惠 12柯彤文 3王拔群 14
中文摘要
背景醫療不良事件(AMEs)的管理是促進病人安全的基石根本原因分析
(RCA)是探討重大病人安全不良事件問題但是由於無法解釋更廣泛的因素而受
到限制本研究使用人為因素分類與分析工具(HFACS)回溯審視醫療不良事件
以了解影響醫療不良事件的人為因素及各層面中錯誤原因之分佈或系統性問題
方法本研究回溯 2012-2016年間有做過根本原因分析之醫療不良事件以連續
性取樣方式(continuous sampling)收集 40例醫療不良事件以人為因素分類與分
析工具(HFACS)去系統性的挖掘每件案例發生錯誤之原因結果在行為層面中
分析結果主要為基礎技能錯誤(95)判斷和決策錯誤(875)其中在基礎技能
錯誤當中以未依程序作業執行(816)及未如預期設備操作(50)佔多數判斷和
決策錯誤中以現場風險評估不確實(686)及採取錯的步驟行為(686)佔多數
而在先決條件層面中以團隊合作(275)為主要因素包含溝通不良(818)及重
要訊息未以正確的方式即時傳達(727)佔多數在監督層面當中以監督不周
(929)或監督不妥當(929)為主要因素在組織政策和流程方面(50)以組織
系統的政策風險未充分評估(35)為主要因素結論本研究進一步了解醫療不
良事件在過去使用根本原因分析未探討到的人為因素反映出潛在的監督組織
行為或系統性的問題促進病人安全預防錯誤再發生
關鍵字病人安全醫療不良事件根本原因分析人為因素
1國泰醫療財團法人國泰綜合醫院 品質管理部
2國立臺灣大學健康政策與管理研究所
3振興醫療財團法人振興醫院 醫療品質管理中心
4輔仁大學醫學院
通訊作者王拔群 電子信箱 drtonyseednettw
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin 112
Submitted January 20 2020
Final version accepted April13
2020
Case Report
Juvenile Caruncular Atypical Lymphoid
Proliferation ndash A Rare Case Report
Cite as Hua-Wei Shih Yu-Chi Lin
Juvenile Caruncular Atypical
Lymphoid Proliferation ndash A Rare
Case Report Fu-Jen Journal of
Medicine 3(3) 112-119 2020
DOI
103966181020932020091803003
Hua-Wei Shih1 Yu-Chi Lin
1
1Department of Ophthalmology Shin Kong Wu Ho-Su Memorial Hos-
pital Taipei City Taiwan
Corresponding author E-mail address
yuchi067gmailcom (Yu-Chi Lin)
ABSTRACT
Lesions of the caruncle are very rare Most caruncular lesions are benign though there were still few reported malignant lesions Ocular adnexal lymphoproliferative disease (OALD) one of the differential diagnosis of caruncular lesion is seldom seen in young pa-tient In this article we report a 16-year-old boy with recurrent caruncular atypical lym-phoid proliferation We discuss the epidemiology clinical features images histomorpholo-gy and treatment between ocular adnexal lymphomas (OAL) and reactive lymphoid hyper-plasia (RLH)
Keywords caruncular lesion ocular adnexal lymphoproliferative disease ocular adnexal lymphoma
reactive lymphoid hyperplasia atypical lymphoid proliferation
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
113
INTRODUCTION Lesions of the caruncle are very rare Differen-
tial diagnosis includes nevus myeloproliferative
disorders tumors inflammation infection cysts
vascular lesions and fibrous Biopsy is essential
for diagnosis Levy J et al reported ocular ad-
nexal lymphoproliferative disease (OALD) was
relatively uncommon diagnosis among caruncu-
lar lesions [1]
OALD was seldom described in Asian popula-
tion especially for young age C-Y Cheng re-
ported age-standardized incidence of ocular
adnexal lymphomas (OAL) in Taiwan from 1979
to 1996 was below 07 per million per year and
mean age was 531 years old [2] In 2015 five
Taiwanese cases of OAL whose age ranging
from 45 to 64 were presented [3] However
there were few cases of conjunctival OAL or
RLH in Chinese pediatric patient
Here we present a case of 16-year-old boy with a
caruncular mass at his left eye with recurrence
one month after excision We describe his clini-
cal symptoms photographs pathological results
management and follow-up clinical course in
this report
CASE REPORT A 16-year-old healthy boy presented a mass
lesion at his left eye caruncle accompanied with
the symptom of tearing for one month (Figure 1)
He had no ocular pain no itchiness no blurred
vision no night sweating no fever and no body
weight loss The patient denied systemic diseas-
es and histories of surgery His bilateral best
corrected visual acuity (BCVA) were 66 and
intraocular pressure (IOP) were both within
normal range There were no remarkable find-
ings for his cornea lens fundus and physical
examination Excision was performed and the
mass was soft with fluid inside therefore con-
junctival pyogenic cyst was our initial diagnosis
However one month after the excision a pro-
truding mass recurred at the patientrsquos nasal can-
thus of left eye (Figure 2) There were some
differences compared to previous condition At
the first time the soft mass was contained in a
well-defined cyst wall which more favored py-
ogenic granulation However after short period
of recurrence solid consistency and unclear
margin were found which favored malignancy
Besides the mass partially involved beyond the
gray line of nasal part lower eyelid whereas last
time the cyst mainly extended from conjunctiva
of caruncle The second excisional biopsy was
performed Pathologic examination demonstrat-
ed abundant atypical lymphoid proliferation
(Figure 3A 3B) Immunohistochemical studies
showed that the lymphoid aggregation was
composed predominantly of CD20-positive cells
(Figure 3C) focal positive staining of CD3
(Figure 3D) CD5 CD23 CD10 and negative
staining of cyclin-D1 Unfortunately the cellular
morphology was difficult to be evaluated due to
marked crushing artifact Thus malignant lym-
phoma cannot be excluded totally
Orbital computed tomography (CT) showed a
lesion of soft tissue density at medial canthus of
left orbit without obvious nasolacrimal duct or
bony invasion (Figure 4A) Magnetic resonance
imaging (MRI) with contrast showed strong
enhancement at left medial canthus region (Fig-
ure 4B) There was no remarkable finding in the
systemic workup including complete blood
count and differential count biochemical pro-
files and 18F-fluoro-2-deoxyglucose positron
emission tomographycomputed tomography
(18F-FDG PETCT) indicating no evidence of
systemic involvement
After the second excision we preferred con-
servative management for him due to the uncer-
tainty of malignancy and to avoid side effects
from aggressive treatment No sign of recurrence
was noted after 10 months of observation The
follow-up photo was taken at three months after
the second operation (Figure 5)
DISCUSSION Ocular adnexal lymphoproliferative disease
(OALD) consists of the spectrum of lymphoid
disease affecting the tissues surrounding the eye
including ocular adnexal lymphomas (OAL) and
lymphoid hyperplasia (LH) [4] The conjunctiva
is an important location for extranodal lympho-
ma development which comprises 25 of OAL
[5]
OAL can be grouped into two categories based
on their appearance of cells under the micro-
scope low-grade and high-grade [6] Extranodal
marginal zone lymphoma of mucosa-associated
lymphoid tissue (EMZLMALT) is the most
common subtype of OAL followed by follicular
lymphoma [7-9] Both of the above are
low-grade lymphomas
LH can be further divided by histopathology into
reactive lymphoid hyperplasia (RLH) and atypi-
cal lymphoid hyperplasia (ALH) RLH has to-
tally benign morphology and immunophenotype
whereas ALH has borderline lesions between
RLH and lymphoma [10] OAL and LH are
mostly seen in patients with age between 50-70
years old There are rare cases in pediatric group
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
114
[71011] In the C-Y Chengrsquos statistical report of
OAL in Taiwan only 8 patients were younger
than 15 years old among the 101 cases of ocular
lymphoma [2] According to an US study inci-
dence rates of OAL were analyzed in different
age groups the group of age over 50 had the
highest incidence rate of 574 per million per-
son-years while the 0-19 age group had the
lowest incidence rate of 009 per million per-
son-years [12] The incidence of LH was even
less than OAL [13]
Patients with OALD may be asymptomatic or
with symptoms of proptosis eyelid swelling a
palpable painless mass or conjunctival salmon
patch Diplopia visual loss pain or inflamma-
tion occurred less frequently implying more
aggressive features [714]
Orbital LH is not distinguishable from low-grade
lymphoma radiologically They both typically
present a round or lobulated mass that diffusely
moderately enhances with contrast and usually
shows homogenous hypointense or isointense to
muscle barely invasion to bone or nervous sys-
tem [10] Atypical appearances including inho-
mogeneous calcification or bony changes may
be seen in high-grade lymphoma case reports
such as ocular adnexal diffuse large B-cell lym-
phoma (DLBCL) which is one of the more ag-
gressive type of OAL [7] Whole body PET is
used for not only the evaluation of systemic
involvement but also the standard for staging
lymphoma Our patientrsquos image studies revealed
neither obvious local invasion nor systemic ma-
lignancy indicating high-grade lymphoma was
less likely Low-grade lymphoma and benign
reactive lymphoid hyperplasia were still under
consideration
Histomorphology analysis and immunohisto-
chemistry (IHC) are essential for diagnosis
Flow cytometry and polymerase chain reaction
(PCR) technique are also applied to help differ-
entiate from RLH and OAL [1016] Our case
had immunohistochemical profile of positivity
for CD20 predominantly positivity focally for
CD3 CD5 CD10 CD23 and negativity for cy-
clin-D1 BCL-6 staining was not performed in
our casersquos biopsy Thus according to the IHC
report RLH ALH and follicular lymphoma are
probable diagnosis of our patient
Radiation therapy is the standard treatment for
low-grade OAL that is classified as T1N0M0 or
T2N0M0 according to the AJCC criteria [15]
İncesoy-Ouml zdemir S et al reported a 10-year-old
boy diagnosed of MALT lymphoma who was
treated with local radiotherapy (36 Gy) and
there were no local or systemic recurrences dur-
ing his nearly four-year follow-up [17] Another
case report represented a 21-year-old man of
conjunctival follicular lymphoma treated with
surgical excision only showing no evidence of
recurrence after 8 months follow-up [18] Other
treatment options for pediatric and juvenile OAL
were performed in some case reports including
intravenous rituximab intralesional interfer-
on-α-2b topical interferon a6 systemic doxycy-
cline surgical excision and postoperative local
cryotherapy [15]
Treatment for young conjunctival RLH was less
discussed in the past In a case series article
three children (9 13 14 years old respectively)
of RLH received surgical resection without fur-
ther postoperative management and no signs of
recurrence were noted during follow-up [19]
Short-term topical and oral corticosteroids after
surgical excision were prescribed in two pediat-
ric RLH patients for their small residual mass
However poor response in both cases was nota-
ble [20]
Our patient declined to receive radiotherapy or
any further postoperative treatment mainly due
to his concerning of possible side effects (such
as dry eye and cataract)
CONCLUSION We present a rare case of caruncle mass in this
report OALD is one of the relatively uncommon
diagnosis among caruncular lesions OALD
includes benign RLH and malignant OAL
which are both mainly seen in elderly patients
even rarer in pediatric or juvenile group
The standard treatment for low-grade OAL and
RLH in young patents are still debatable How-
ever long-term follow-up is suggested for both
OAL and RLH patients Though RLH has a be-
nign and self-limited course risk of malignant
transformation is possible
REFERENCES 1 Levy J Ilsar M Deckel Y et al Lesions of
the caruncle a description of 42 cases and
a review of the literature Eye
200923(5)1004-1018
2 C-Y Cheng and W-M Hsu Incidence of
eye cancer in Taiwan an 18-year review
Eye 200418152-158
3 Chui-Lien Tsen Muh-Chiou Lin
Youn-Shen Bee et al Ocular adnexal
lymphoma Five case reports and a
literature review Taiwan Journal of
Ophthalmology 20155(2)99-102
4 Liesegang TJ Ocular adnexal
lymphoproliferative lesions Mayo Clin
Proc 199368(10)1003-1010
5 Kirkegaard MM Coupland SE Prause JU
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
115
et al Malignant lymphoma of the
conjunctiva Surv Ophthalmol
201560(5)444-458
6 Stacy RC Jakobiec FA Schoenfield L et
al Unifocal and multifocal reactive
lymphoid hyperplasia vs follicular
lymphoma of the ocular adnexa Am J
Ophthalmol 2010150(3)412-426
7 Sullivan TJ Ocular Adnexal
Lymphoproliferative Disease In Guthoff
RF Katowitz JA eds Oculoplastics and
Orbit Berlin Heidelberg Springer
20101-19
8 White Valerie A Understanding and
Classification of Ocular Lymphomas
Ocular Oncology and Pathology
20195379-386
9 Stefanovic A Lossos IS Extranodal
marginal zone lymphoma of the ocular
adnexa Blood 2009114(3)501-510
10 Andrew NH Coupland SE Pirbhai A et al
Lymphoid hyperplasia of the orbit and
ocular adnexa A clinical pathologic review
Surv Ophthalmol 201661(6)778-790
11 Ferry JA1 Fung CY Zukerberg L et al
Lymphoma of the ocular adnexa A study
of 353 cases Am J Surg Pathol
200731(2)170-184
12 WM Hassan MS Bakry HM Hassan et al
Incidence of orbital conjunctival and
lacrimal gland malignant tumors in USA
from Surveillance Epidemiology and End
Results 1973-2009 Int J Ophthalmol
20169(12)1808-1813
13 Ajay A Rao John H Naheedy James Y-Y
Chen et al A Clinical Update and
Radiologic Review of Pediatric Orbital
and Ocular Tumors Journal of Oncology
2013(9)975908
14 Sullivan TJ Whitehead K Williamson R
et al Lymphoproliferative disease of the
ocular adnexa a clinical and pathologic
study with statistical analysis of 69
patients Ophthal Plast Reconstr Surg
200521177-188
15 Tanenbaum RE Galor A Dubovy SR et al
Classification diagnosis and management
of conjunctival lymphoma Eye Vis (Lond)
2019622
16 Olga Klavdianou Georgios Kondylis
Vasileios Georgopoulos et al Bilateral
benign reactive lymphoid hyperplasia of
the conjunctiva a case treated with oral
doxycycline and review of the literature
Eye Vis (Lond) 2019626
17 İncesoy-Ouml zdemir S Yuumlksek N Bozkurt C
et al A rare type of cancer in children
extranodal marginal zone B-cell (MALT)
lymphoma of the ocular adnexa Turk J
Pediatr 201456(3)295-298
18 Lynn J Poole Perry Frederick A Jakobiec
Peter A D Rubin Conjunctival Pediatric
Follicular Lymphoma Arch Ophthalmol
2012130(7)941-943
19 Abdullah Al-Mujaini Upender Wali
Anuradha Ganesh1 et al Ocular Adnexal
Reactive Lymphoid Hyperplasia in
Children Middle East Afr J Ophthalmol
201219(4)406-409
20 McLeod SD Edward DP Benign
lymphoid hyperplasia of the conjunctiva in
children Arch Ophthalmol
1999117(6)832-835
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
116
FIGURES
Figure 1 Slit lamp image of a mass lesion at the patientrsquos left eye caruncle for one month
Figure 2 One month after the first excision a protruding mass recurred at the patientrsquos nasal canthus
of left eye It partially involved beyond the gray line of nasal part lower eyelid
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
117
Figure 3 Histomorphology analysis and immunohistochemistry study of the caruncular lesion Abun-
dant atypical lymphoid proliferation presented in low-power photomicrograph (A) and
high-power photomicrograph (B) under hematoxylin-eosin staining The lymphoid aggrega-
tion was composed predominantly of CD20-positive cells (C) and focal positive staining of
CD3 (D)
Figure 4 Non-contrast orbital computed tomography showed a lesion of soft tissue density at medial
canthus of left orbit without obvious nasolacrimal duct or bony invasion (A) Magnetic reso-
nance imaging with contrast showed strong enhancement at left medial canthus region (B)
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
118
Figure 5 The follow-up photo were taken at three months after the second excision showing no signs
of recurrence
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
119
Juvenile Caruncular Atypical Lymphoid Proliferation ndash A Rare Case Report
罕見病例報告mdash青少年之淚阜非典型淋巴增生
施驊瑋 1林友祺 1
中文摘要
淚阜病灶相當罕見大部分為良性病灶眼睛及附屬結構淋巴增生疾病為其
鑑別診斷之一非常少見於年輕人或兒童我們報告一位 16歲的健康男性因
左眼淚阜無痛性腫塊接受切除手術卻於術後一個月復發執行第二次切除手術
後門診追蹤十個月未再復發此案例表現了部分良性與部分惡性腫瘤的特徵
我們針對反應性淋巴增生眼睛及附屬結構淋巴癌兩個疾病做討論及文獻回顧
關鍵字淚阜病灶眼睛及附屬結構淋巴增生疾病眼睛及附屬結構淋巴癌反
應性淋巴增生非典型淋巴增生
1 新光吳火獅紀念醫院眼科
通訊作者林友祺 電子信箱 yuchi067gmailcom
Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh 120
Submitted March 26 2020
Final version accepted April 16
2020
Case Report
Hyperacute intramembranous hemor-
rhage after burr hole craniostomy for
chronic subdural hematoma
Cite as Meng-Chi Lin Jui-Ming
Sun Yu-Hao Chen Cheng-Ta
Hsieh
Hyperacute intramembranous
hemorrhage after burr hole crani-
ostomy for chronic subdural he-
matoma Fu-Jen Journal of Medi-
cine 3(4) 120-125 2020
DOI
103966181020932020091803004
Meng-Chi Lin1 Jui-Ming Sun23 Yu-Hao Chen24 Cheng-Ta
Hsieh567
1Department of Surgery Zuoying Branch Kaohsiung Armed Forces
General Hospital Kaohsiung 813 Taiwan 2Section of Neurosurgery Department of Surgery Chia-Yi Christian
Hospital Chia-Yi City 600 Taiwan 3Department of Biotechnology Asia University Taichung City 41354
Taiwan 4Chung-Jen Junior College of Nursing Health Sciences and Manage-
ment Chia-Yi Country 62241 Taiwan 5Division of Neurosurgery Department of Surgery Sijhih Cathay Gen-
eral Hospital New Taipei City 22174 Taiwan 6Department of Medicine School of Medicine Fu Jen Catholic Univer-
sity New Taipei City 24205 Taiwan 7Department of Neurological Surgery Tri-Service General Hospital
National Defense Medical Center Taipei 114 Taiwan
Corresponding author E-mail address
nogormail2000comtw (Cheng-Ta Hsieh)
ABSTRACT
Burr hole craniostomy with closed-system drainage is an effective and common neurosurgical procedure to manage chronic subdural hematoma Postoperative hem-orrhage a well-known but infrequent complication may result in increased neurolog-ical deficits However hyperacute intramembranous hemorrhage within the inner and outer membrane of hematoma after burr hole craniostomy with irrigation and closed-system drainage has not been described previously Herein we report a case of postoperative spontaneous hyperacute intramembranous hemorrhage after burr hole craniostomy with closed-system drainage to manage a chronic subdural hematoma we subsequently discuss the possible pathophysiological mechanisms and review the relevant literature
Keywords Chronic subdural hematoma acute subdural hematoma bleeding burr hole craniostomy
drainage
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Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh
125
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
慢性硬腦膜下出血進行鑽顱引流手術造成超急性夾膜內出
血
林孟楫 1孫瑞明 23陳昱豪 24謝政達 567
中文摘要
鑽顱併封閉系統引流手術是治療慢性硬腦膜下出血患者一種有效且常見的
神經外科手術方式術後出血可能導致神經功能缺損惡化是眾所周知但不常見
的併發症之一然而至今仍未有鑽孔併封閉系統引流造成原本慢性硬腦膜血
塊內膜和外膜間急性夾膜間出血案例在這裡我們報告一例慢性硬腦膜下出
血病患者接受鑽顱併封閉系統引流手術治療造成術後急性夾膜間出血我們在
本文中討論可能的致病機制並回顧相關文獻
關鍵字慢性硬腦膜下出血急性硬腦膜下出血出血鑽顱術引流
1國軍高雄總醫院左營分院 外科部
2崇仁醫護管理專科學校
3亞洲大學 生物科技學系
4戴德森醫療財團法人嘉義基督教醫院 外科部 神經外科
5汐止國泰綜合醫院 神經外科
6輔仁大學 醫學系
7 國防醫學院 三軍總醫院 神經外科
通訊作者謝政達 電子信箱 nogormail2000comtw
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
126
Submitted January 21 2020
Final version accepted July 08
2020
Case Report
Hamartoma of the breast A case report
Cite as Hsuan-An Chen
Cheng-Yu Lo Shih-Hung Huang
Chin-Lung Lin
Hamartoma of the breast A case
report Fu-Jen Journal of Medicine
3(5) 126-130 2020
DOI
103966181020932020091803005
Hsuan-An Chen1 Cheng-Yu Lo
3 Shih-Hung Huang
3 Chin-Lung
Lin2
1Department of Surgery Cathay General Hospital Taipei Taiwan
2Department of General Surgery Cathay General Hospital Taipei Tai-
wan
3Department of Pathology Cathay General Hospital Taipei Taiwan
Corresponding author E-mail address
lungyungmailcom (Chin-Lung Lin)
ABSTRACT
Breast hamartoma is an uncommon benign tumor rarely associated with malignancy An
excision and histological examination is necessary for the differential diagnosis We report
a case of a 49-year-old female patient presenting with a lump in the right breast Ultrasound
examination which demonstrated a 4411 cm hypoechoic lesion with lipoma Partial mas-
tectomy was arranged and the diagnosis of a hamartoma was confirmed by the histological
examination
Keywords Breast tumor Hamartoma Ultrasound
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
127
INTRODUCTION The hamartoma is a benign tumor-like lesion
that can affect various organs of the body in-
cluding lungs kidneys skin and more rarely the
breast In 1981 the hamartomas were recognized
in the WHO classification[1] They are defined
as well-demarcated mass of mammary ducts and
lobules containing varying amounts of fibrous
and adipose tissue and producing a distinctive
mammographic image
CASE REPORT A 49 year-old female had past history of left
breast mastitis with abscess status post partial
mastectomy This time she presented to our out
patient clinic for breast examination Physical
examination revealed a painless palpable mova-
ble and painless lump at upper outer quadrant of
right breast The risk of breast cancer was not
noted and the patient did not have any family
history of breast cancer The patient also denied
any trauma history before Ultrasound examina-
tion was arranged which demonstrated a 4411
cm hypoechoic lesion with lipoma at 3 oclock 2
cm from nipple of right breast and multiple hy-
poechoic nodules of various size in both breasts
and there was no suspicious axillary lymph
nodes noted (Figure1) Surgical treatment was
arranged partial mastectomy of right breast
harmartoma was successfully performed A 32 x
31 x 21 cm tumor was completely excised
Grossly examination showed a gray to yellow
and firm to fatty The diagnosis of a hamartoma
was confirmed by the histological examination
Microscopically sections of the breast lesion
show mammary hamartoma composed of ducts
lobules with interlobular fibrous tissue and adi-
pose tissue Fibrocystic change apocrine meta-
plastic ducts and scattered foci of adenosis are
noted The overall lobulocentric architecture and
the 2-cell pattern of the epithelium are preserved
columnar cell change and focal microcalcifica-
tion are present (Figure2) Based on submitted
biopsy specimen in-situ or invasive tumor cells
are not identified
DISCUSSION Hamartoma of the breast is a benign tumor like
nodule it was also known as fibroadenolipoma
lipofibroadenoma or adenolipoma based on its
predominant components It was composed of
varying amounts of glandular adipose and fi-
brous tissue[2] Hamartomas were first described
in 1971 by Arrigoni et al in a study of 10 patients
which breast tumors clinically and grossly re-
sembled fibroadenomas[3]
A higher predominance of tumors exists in fe-
males compared with males Hamartomas are
slowly-growing lesions with the diameter rang-
ing from 2 cm to 5 cm sometimes hamartomas
can reach giant diameter [4]
The clinical diagnosis of hamartoma is based on
the findings from mammography sonography
and histology examinations The hamartomas are
usually incidentally diagnosed by the women
older than 40 year-old starting mammography
screening
On physicial examination harmatomas are usu-
ally occult painless they may be as large mo-
bile soft to firm masses[5] Ultrasound showed
well capsulated mass with echogenic rim and
internal heterogeneity Mammography exam
showed well-circumscribed round to oval
masses containing fat and soft tissue densities
with a thin radiopaque pseudocapsule The
pseudocapsule results from displacement of
breast parenchyma by the tumor [56] In Pa-
thology finding microglandular adenosis is pre-
sent in fibroadipose stroma surrounded by a thin
fibrous capsule It composed of a combination of
epithelial and stromal elements usually with
normal ducts or lobules although variations of
normal tissue may also be seen Fibroadenoli-
poma myoid hamartoma and chondrolipoma are
histological variations of hamartomas depend-
ing on the proportion of normal breast tissue
elements[7]
Malignancy associated with hamartomas are
very rare[8] However it has been reported
hamartomas develop into carcinoma Malignant
transformation can occur as a result of cellular
atypia in the epithelial component of the mass[9]
Surgical removal is the curative method for
breast hamartomas[10] Diagnostic material such
as mammography ultrasonography or core nee-
dle biopsy may not give the definitive diagnosis
Therefore surgical excision and histological
examination is necessary for differential diagno-
sis[111213]
Although it is rare hamartoma can be seen along
with malignancy as it is formed from similar
components of breast tissue Therefore careful
diagnosis and appropriate management including
surgery are required
REFERENCES 1 World Health Organization (1981)
Histological typing of breast tumors In
International histological classification of
tumors 1981 2nd ed
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
128
2 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11435ndash449
2006
3 ArrigoniMG DockertyMB JuddES
The identificationand treatment of
mammary hamartoma Surg Gynecol
Obstet1971 133 577-82
4 Sanal HT Ersoz N Altinel O Unal E Can
C Giant hamartoma of the breast Breast J
2006 12 84-85
5 Feder JM de Paredes ES Hogge JP
Wilken JJ Unusual breast lesions
radiologic-pathologic correlation
Radiographics 1999 19S11ndashS26
6 Murat A Ozdemir H Yildirim H Poyraz
AK Ozercan R Hamartoma of the breast
Australas Radiol 200751 Spec NoB37ndash
9
7 Fisher CJ Hanby AM Robinson L Millis
RR Mammary hamartoma-a review of 35
cases Histopathology 1992 20 99-106
8 Choi N Ko ES Invasive ductal carcinoma
in a mammary hamartoma case report and
review of the literature Korean J Radiol
2010 Nov-Dec11(6)687-91
9 Lee EH Wylie EJ Bourke AG Bastiaan
De Boer W Invasive ductal carcinoma
arising in a breast hamartoma two case
reports and a review of the literature Clin
Radiol 2003 58 80-3
10 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11 435 ‑449
2006
11 Coyne J Hobbs FM Boggis C Harland R
Lobular carcinoma in a mammary
hamartoma J Clin Pathol 199245936ndash
937
12 G M K Tse B K B Law T K F Ma A B W
Chan Hamartoma of the breast a
clinicopathological review J Clin Pathol
200255951ndash954
13 RAAmir SSheikh BreasthamartomaA
report of 14cases of an under-recognized
and under-reported entity International
Journal of Surgery Case Reports
22(2016)1ndash4
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
129
FIGURES
Figure 1 Ultrasound shows a 4411 cm hypoechoic lesion with lipoma at 3 oclock 2 cm from nipple
of right breast
Figure 2 Photomicrograph shows mammary hamartoma composed of ducts lobules with interlobular
fibrous tissue and adipose tissue
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
130
Hamartoma of the breast A case report
乳房錯構瘤罕見個案報告
陳宣安 1羅承裕 3黃世鴻 3林錦龍 2
中文摘要
乳房錯構瘤是一種罕見之乳房良性腫瘤切除手術及病理化驗來做鑑別診斷
我們報告一位 49歲女性以可觸摸到無痛性右側乳房腫塊為臨床表徵超音波
看到一個邊緣清楚低迴音的腫塊病患接受手術切除病灶病理診斷證實為乳
房錯構瘤
關鍵字乳房腫瘤錯構瘤超音波攝影
1國泰綜合醫院外科部
2國泰綜合醫院一般外科
3國泰綜合醫院病理科
通訊作者林錦龍 電子信箱 lungyungmailcom
Fu-Jen Journal of Medicine
Mission and Goals
The Fu-Jen Journal of Medicine (FJJM) is a peer-reviewed journal which
aims to enhance research quality of staffs in the College of Medicine Fu Jen
Catholic University The journal publishes original investigations across a
wide range of medical disciplines including original research articles in basic
and clinical sciences case reports review articles brief reports and letter
to the editor FJJM is now issued by the Center of Medical Education in the
College of Medicine Fu Jen Catholic University To promote journal quality
the manuscript submitted to FJJM after August first 2015 has to be prepared
in English to meet the international standards
Issue Date
Publication Date
Institution
December 01 2003
September 30 2020
College of Medicine Fu Jen Catholic University
Honorable publisher Han-Sun Chiang
Publisher Ping-Keung Yip
Editor-in-chief Ming-Chieh Ma
Associate Editors Yu-Wen Lin
Editors
Telephone (02) 2905-3477
Address Center for Medical Education College of Medicine Fu Jen
Catholic University
No 510 Zhongzheng Rd Xinzhuang Dist New Taipei City
24205 Taiwan
Su-Jane Wang Chi-Chung Wang Chih-Ming Ho
Yih-Jing Lee Chih-Shung Wong Tze-Wah Kao
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- 9月封面
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Fu-Jen Journal of Medicine Vol 3 No 1 2020
Remifentanil versus fentanyl for MICS
Meng-Chieh Ho Wei-Horng Jean Tzu-Yu Lin Cheng-Wei Lu 89
Submitted October 17 2019
Final version accepted November
01 2019
Original Research Article
A Comparison of Remifentanil and Low
Dose Fentanyl for Postoperative Recovery
Profile in Patients Undergoing Minimally
Invasive Cardiac Surgery
Cite as Meng-Chieh Ho
Wei-Horng Jean Tzu-Yu Lin
Cheng-Wei Lu
A Comparison of Remifentanil
and Low Dose Fentanyl for Post-
operative Recovery Profile in
Patients Undergoing Minimally
Invasive Cardiac Surgery
Fu-Jen Journal of Medicine 3(1)
89-98 2020
DOI
103966181020932020091803001
Meng-Chieh Ho1 Wei-Horng Jean12 Tzu-Yu Lin12 Cheng-Wei
Lu12
1Department of Anesthesiology Far Eastern Memorial Hospital Ban-
qiao Dist New Taipei City Taiwan 220 2Department of Mechanical Engineering Yuan Ze University Taoyuan
Taiwan 320 Contributed equally
Corresponding author E-mail address
drluchengweigmailcom (Cheng-Wei Lu)
ABSTRACT
Background The concept of enhanced recovery after surgery (ERAS) is flourishing in multiple specialties including cardiac surgery Beside minimally invasive surgical ap-proach short acting anesthetic agent is one of the major components of ERAS programs Remifentanil is an ultrashort acting opioid agent The purpose of this study was to compare remifentanil and low dose fentanyl for postoperative recovery profile in patients undergoing minimally invasive cardiac surgery (MICS) Methods This study was a retrospective study We compared the recovery profile including extubation time after surgery length of hospi-tal stay postoperative morphine consumption pain scores and in hospital complication rate between patients undergoing elective MICS from May to August 2018 Results Fifty-three patients were enrolled in this study 33 of them were in group remifentanil (G remifentanil) and 20 were in group fentanyl (G fentanyl) The extubation times average hospital stay postoperative morphine consumption pain scores and in hospital complication rate were all similar between both groups Conclusion We consider remifentanil can be safely used in MICS and provides similar recovery profile as low dose fentanyl
Keywords minimally invasive cardiac surgery enhanced recovery after surgery opioids
Fu-J
Meng
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Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang
99
Submitted October 11 2019
Final version accepted February
02 2020
Original Research Article
Human Factors Underlying Adverse
Medical Events Revisit Root Cause Anal-
ysis Cases Using the HFACS
Cite as Yu-Hsun Cheng
Sheng-Hui Hung Tung-Wen Ko
Pa-Chun Wang
Human Factors Underlying Ad-
verse Medical Events Revisit
Root Cause Analysis Cases Using
the HFACS Fu-Jen Journal of
Medicine 3(2) 99-111 2020
DOI
103966181020932020091803002
Yu-Hsun Cheng1 Sheng-Hui Hung
12 Tung-Wen Ko
3 Pa-Chun
Wang14
1Department of Quality Management Cathay General Hospital Taipei
Taiwan
2Institute of Health Policy and Management National Taiwan Universi-
ty Taipei Taiwan
3Center for Healthcare Quality Management Cheng Hsin General Hos-
pital Taipei Taiwan
4Fu Jen Catholic University School of Medicine New Taipei City Tai-
wan
Corresponding author E-mail address
drtonyseednettw (Pa-Chun Wang)
ABSTRACT Background Appropriate management of adverse medical events (AMEs) is the corner-
stone of patient safety Root cause analysis (RCA) is used to investigate serious or
high-frequency errors but is limited by its inability to explain a broader scope of factors
We re-reviewed RCA cases to understand the underlying human organizational or system-
ic factors affecting AMEs Methods A total of 40 consecutive RCA cases (2012-2016) were
retrieved from the AMEs database A panel was organized to retrospectively re-review these
cases using the Human Factor Analysis and Classification System HFACS Results For
active failures errors stemmed largely from performance-based (95) judgment and deci-
sion-making errors (875) Incorrectly followed procedures (816) and accidental
equipment operation (50) were the most common types of performance-based errors In-
adequate real-time assessment (686) and inappropriate operative actions (686) were
the most common decision-making errors For sources of latent failure teamwork problems
(275) including failure to effectively communicate (818) and communicate critical
information (727) were common Inadequate supervision (929) or command over-
sights (929) were the most common problems related to inadequate supervision (35)
Organizational programpolicy risks not adequately assessed (50) were the most common
problems related to policy and process problem (25) Conclusions The HFACS review
enhances our understanding of human factors underlying AMEs The HFACS reveals latent
supervisory organizational or systematic problems that cannot be addressed through tradi-
tional RCA Keywords patient safety adverse events root cause analysis human factors
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 100
INTRODUCTION Patient safety involves the reduction of patient
harm from potentially avoidable unintended
outcomes [1] Studies have revealed that 50ndash
80 of adverse medical events (AMEs) are pre-
ventable [2-4] to eliminate such errors the ap-
propriate management of AMEs hence repre-
sents the cornerstone of patient safety work
Through incident reporting investigation and
analysis healthcare providers can correct or
re-engineer their care processes to prevent inci-
dent recurrence [25] One of the most popular
tools for investigating AMEs is root cause anal-
ysis (RCA) RCA reconstructs a chain of errors
to identify the deviation of care from normal
processes Nonetheless with a lack of standard-
ized nomenclature and investigation procedures
RCA report conclusions are sometimes too sub-
jective and nonspecific to facilitate any actiona-
ble safety improvement plans [5-7] According
to the UK Health and Safety Executive defini-
tion human factors are environmental organiza-
tional occupational or individual human char-
acteristics which influence behavior at work
such that health and safety are affected [8] Hu-
mans and systems are prone to errors and stud-
ies have showed that nearly 70 of medical
errors involve human factors [2-4] Reasonrsquos
Swiss cheese model described the penetration of
causative human errors through layers of defen-
sive barriers leading to system collapse [9]
With much focus on the temporal sequence and
severity of departure from accepted practices in
an incident the effectiveness of RCA is often
challenged by its incapability of exploring un-
derlying human organization or even systemic
factors [5-7] Reason and others have proposed
that errors can occur at 4 levels 1) unsafe acts
(operator actions) 2) preconditions for unsafe
acts (environmental factors contributing to er-
rors) 3) inadequate supervision (management
actions affecting the operator) and 4) organiza-
tional influences (organizational culture policies
and procedures that affect the operator) [9]
Based on this theory Wiegmann and Shappell
developed the Human Factor Analysis Classifi-
cation System (HFACS) to describe human fac-
tors causing accidents from 4 tiers of categories
Each of these categories consists of nanocodes to
represent specific human behavior or system
problems leading to errors [9-10] The tier for
unsafe acts involves actual provider actions (er-
rors or rule violations) directly leading to events
The tier representing preconditions for unsafe
acts includes operational personnel and envi-
ronmental factors The supervision tier addresses
leadership problems operational planning fail-
ure or correction and supervisory ethics The
tier for organizational influences deals with re-
source management organizational climate and
operational processes (Supplement Table 1) The
HFACS provides standardized investigation
processes for the systematic analysis of common
causes of adverse events across national defense
nuclear power navy aviation and healthcare
industries Taiwan launched its nationwide
AME-reporting system the Taiwan Patient
Safety Reporting System (TPR) in 2004 RCA
methodology was subsequently introduced to the
healthcare industry by the Joint Commission of
Taiwan [11] Since 2012 appropriate manage-
ment of AMEs has been listed as a national pa-
tient safety goal [12] RCA is required by the
Ministry of Health and Welfare for major AMEs
Aside from RCA a comprehensive structural
reliable and valid framework is urgently re-
quired to further guide organizational or even
national patient safety policies In this study we
used the HFACS to review our RCA cases aim-
ing to investigate human factors underlying se-
vere or frequent AMEs
MATERIALS AND METHODS Through continuous sampling 40 consecutive
RCA cases (2012-2016) were retrieved from a
hospitalrsquos (Cathay General Hospital Taipei
Taiwan) AME-reporting system database The
database contains AMEs relating to areas such as
medication patient falls surgery transfusion
clinical care public accidents security hospital
violence tube-related complication unplanned
cardiopulmonary resuscitation laboratory testing
and examination and anesthesia The RCA cases
were sentinel or high-frequency events classified
according to severity assessment category (SAC)
[1113] The SAC is an evaluation method for
categorizing AMEs by severity of effect on pa-
tients health and risk of incident reoccurrence
The HFACS has been modified (from the US
Department of Defense version 70) and trans-
lated into Mandarin Chinese with authorization
from the original developers [10] The Chi-
nese-version HFACS for Taiwan is a valid in-
strument (content validity index 09 Cronbachrsquos
α gt07 interrater reliability Κ 04-10) equiva-
lent to the original English version [9] The
HFACS contains 4 tiers 13 subitems and 109
nanocodes (Supplement Table 1) A panel of 6
reviewers was established All reviewers were
from clinical or management (quality and patient
safety management) backgrounds Reviewers all
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 101
finished human factor education and were
trained to use the HFACS through a consensus
meeting Each RCA case was randomly assigned
to 2 reviewers Human factors leading to partic-
ular AMEs were identified and confirmed when
2 reviewers reached agreement The distribution
of errors among tiers subitems and nanocodes
are provided with descriptive statistics () The
study was approved by the Institutional Review
Board of Cathay General Hospital
(CGH-P105095)
RESULTS AMEs related to laboratory testing and examina-
tion (n = 16) clinical care (n = 9) and medica-
tion (n = 7) were the most commonly observed
in the RCA Most AMEs in this cohort are
ranked as being SAC level 3 (n = 15) or 4 (n =
17) (Table 1)
Acts (Active Failures)
This tier of errors contains 3 subitems and 13
nanocodes In the 40 RCA cases perfor-
mance-based errors for 38 (95) and judgment
and decision-making errors for 35 (875) com-
prised the most common error types with viola-
tion for 6 (15) less common Procedure fol-
lowed incorrectly for 31 out of 38 (816) was
the most common performance-based problem
Inadequate real-time risk management for 24 out
of 35 (686) was the most common judgment
or decision error All of the rule violations were
workaround types for 6 out of 6 (100) (Figure
1)
Preconditions(Latent Failures)
This tier of errors has 9 subitems and 58 nano-
codes In the 40 RCA cases teamwork for 11
(275) and environmental for 8 (20) factors
contributed to most of the errors with mental
and physical state the next most common factor
for 7 (175) Communication for 9 out of 11
(818) and information relay for 8 out of 11
(727) were the most common issues related to
teamwork Few contributors mentioned failures
related to technical errors for 4 (50) or physi-
cal for 1 (125) environment Not paying at-
tention for 4 out of 7 (571) and negative habit
transfer for 4 out of 7 (571) were common
mental contributes noted for 7 (100) Overcon-
fidence was the most common problem related
to emotional status for 4 out of 7 (571) Fa-
tigue was observed in only 2 cases for 2 out of 2
physical problems (100) (Figure 2)
Supervision(Direct Supervisory Chain of
Command)
This tier of errors contains 3 subitems and 17
nanocodes In the 40 RCA cases inadequate
supervision for 14 (35) and inappropriately
planned operations for 11 (275) factors con-
tributed to most of the respective errors fol-
lowed by supervisory violations for 7 (175)
Supervisory or command oversights for 13 out
of 14 (929) were the most common sources of
supervision inadequacy Authorized unnecessary
hazards for 7 out of 11 (636) were the most
common inappropriately planned operations
Failure to enforce rules for 6 out of 7 (857)
was the most common supervisory violation
(Figure 3)
Organization Influence (Upper-Level Man-
agement)
This tier of errors contains 4 subitems and 18
nanocodes In the 40 RCA cases policy and
process issues for 10 (25) and resources prob-
lem for 8 (20) were major concerns Few of
the respective problems are related to climate
and cultural influences for 2 (5) or to person-
nel selection and staffing for 1 (25) Poorly
assessed organizational programs or policy risks
for 5 out of 10 (50) were the most common
policy and process problems Failure to provide
adequate operational information resources for 4
out of 8 (50) and command and control re-
source deficiency for 3 out of 8 (375) were
the main resource management problems Little
was revealed regarding organizational climate
and culture (n = 1 out of 2 50) or staffing for 1
out of 1 (100) (Figure 4)
DISCUSSION Health care is a complex system comprising
many high-reliability organizations (HROs) The
vulnerability of HROs stems from the participa-
tion of multidisciplinary teams in the processes
along a variety of patient care timelines How-
ever humans and systems are inherently prone
to errors the appropriate management of AMEs
is acknowledged to be the cornerstone of patient
safety AMEs should be reported investigated
analyzed and handled appropriately[14] Theo-
retically by analyzing the pattern of key defects
providers can fix errors and re-engineer their
care processes to reduce the possibility of AME
recurrence Taiwan established its nationwide
TPR in 2004 so far 7000 health care facilities
have participated and the database has accumu-
lated more than 055 million AMEs[11] Infor-
mation generated from the TPR database can
improve patient safety at individual organiza-
tional or even national levels However despite
relentless efforts few substantial improvements
have been achieved in patient safety [15-17]
Since its introduction in Taiwan in 2006 the use
of RCA for AMEs has encountered some diffi-
culties 1) No structural and standardized
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 102
framework exists for investigation
cross-institution variability and interrater relia-
bility are often ignored 2) Conclusions are often
subjective and corrective recommendations are
less actionable relying on individual reviewersrsquo
professional backgrounds and their experiences
3) Much focus on event reconstruction and oper-
ator performance means that factors relating to
human behavior organizational culture and
system weakness are not comprehensively ad-
dressed [671718] Traditionally attempts to
improve patient safety in the health care industry
are largely reactive in nature identifying and
correcting errors in care processes [1920]
Causes of defects are not thoroughly understood
Proactive approaches must be taken to address
systematic problems within a complex system
[720] Research suggests that human error is a
causal factor in the occurrence of AMEs AME
investigation targets have moved from skill defi-
ciency toward decision-making attitudes super-
visory factors and even organizational climate
or culture HFACS methodology is based on the
Swiss cheese model that also emphasizes active
and latent failures [921] The study provides
some noteworthy findings First most AMEs as
expected involve active failures such as failure
to follow procedure accidental operation of
equipment inadequate real-time risk manage-
ment and inappropriate action These are all
sharp ends in classic RCA environment physi-
cal and mental factors are less prevalent This
proves that retrospectively determining addi-
tional causal factors is difficult when infor-
mation has not been collected during preliminary
investigation (Figure 1) Second team-
work-related problems particularly in relation to
communication and information relay are well
addressed This may be attributed to the dec-
ade-long institution-wide routine crew resource
management training in the respective research
hospital (Figure 2) Third the HFACS success-
fully reflects the importance of supervisory roles
in the occurrence of AMEs and this cannot be
overlooked (Figure 3) Fourth latent failures
especially in organizational climate or cultural
dimensions have been less frequently addressed
in incident reports a limitation of traditional
RCA However the HFACS review suggests
room for improvement in resource allocation and
policy modification within the hospital The
results of studies can make the organization
think about how to improve the patient safety
and management process from the perspective of
human factors such as improving the comfort of
the working environment and replacing and
equipment resources to prevent personnel from
affecting the medical quality and patient safety
due to the environment or equipment Need to
appropriate assessment of applicability and ade-
quate training of manpower is required The
management and control of risks should be fully
evaluate and grasp resource management and
leaders need to participate in and promote medi-
cal quality and patient safety activities to en-
hance its culture (Figure 4) No panacea exists
to ensure patient safety and improvement targets
originate largely from event investigation find-
ings Unfortunately factors identified from
AMEs are often self-explanatory with little value
for further action correction Reinforcement of
policy or processes redundant education or
repetitious training are formulaic overprescribed
RCA recommendations The use of HFACS in
this study proves that a structural prospective
AME investigation format can potentially help
with proactive patient safety management We
suggest developing an interview guideline for
the routine use of HFACS as a complement to
RCA in every AME investigation This study is a
retrospective study The underlying human fac-
tors can be under-estimated owing to the lack of
related information in the original RCA reports
CONCLUSION The HFACS review in this study enhances our
understanding of human factors in AMEs that
had previously been insufficiently scrutinized
Aside from active process and communication
errors the HFACS enables the prospective in-
vestigation of latent supervisory organizational
or systematic problems that cannot be addressed
through traditional RCA
REFERENCES 1 T Brennan L Leape N Laird et al
Incidence of adverse events and
negligence in hospitalized patients results
of the Harvard Medical Practice Study I N
Engl J Med 1991324370-376
2 Wang CH Shih CL Chen WJ et al
Epidemiology of medical adverse events
perspectives from a single institute in
Taiwan J Formos Med Assoc
2016115434-439
3 Vincent C Simon R Sutcliffe K et al
Errors Conference Executive Summary
Acad Emerg Med 200071180-1182
4 Taitz J Genn K Brooks V et al
System-wide learning from root cause
analysis A report from the New South
Wales Root Cause Analysis Review
Committee Qual Saf Health Care
2010191-5
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 103
5 Hutchinson A Young TA Cooper KL et
al Trends in healthcare incident reporting
and relationship to safety and quality data
in acute hospitals results from the
National Reporting and Learning System
Qual Saf Health Care 2009185-10
6 Mitchell RJ Williamson AM Molesworth
B et al A review of the use of human
factors classification frameworks that
identify causal factors for adverse events
in the hospital setting Ergonomics
2014571443-1472
7 Gurses AP Ozok AA Pronovost PJ Time
to accelerate integration of human factors
and ergonomics in patient safety BMJ
Qual Saf 201221347-351
8 Health and Safety Executive Introduction
to human factors
httpwwwhsegovukhumanfactorsintro
ductionhtm
9 Wiegmann DA Shappell SA A human
error approach to aviation accident
analysis The human factors analysis and
classification system Burlington VT
Ashgate Publishing Ltd 2003
10 Yu-Hsun Cheng Sheng-Hui Hung
Tung-Wen Ko et al An Analysis of the
Reliability and Validity of Human Factors
Analysis Classification System in Medical
Adverse Events Journal of Healthcare
Quality 20191370-76
11 Taiwan Joint Commission on Hospital
Accreditation Taiwan Patient-Safety
Reporting System Annual Report 2017
New Taipei City Taiwan
12 Taiwan Patient Safety Net
httpwwwpatientsafetymohwgovtwCo
ntentzMessagesslistaspxSiteID=1ampMm
mID=621273300317401756
13 Government of Western Australia
Department of Health
httpsww2healthwagovauArticlesS_T
Severity-assessment-codes
14 Farley DO Haviland A Champagne S et
al Adverse-event-reporting practices by
US hospitals results of a national survey
Qual Saf Health Care 200817416-423
15 Shojania KG Thomas EJ Trends in
adverse events over time why are we not
improving BMJ Qual Saf
201322273-277
16 Levitt P Challenging the systems approach
why adverse event rates are not improving
BMJ Qual Saf 2014231051-1052
17 Kellogg KM Hettinger Z Shah M et al
Our current approach to root cause
analysis is it contributing to our failure to
improve patient safety BMJ Qual Saf
201726381-387
18 Khorsandi M Skouras C Beatson K et al
Quality review of an adverse incident
reporting system and root cause analysis of
serious adverse surgical incidents in a
teaching hospital of Scotland Patient Saf
Surg 2012621
19 Diller T Helmrich G Dunning S et al
The Human Factors Analysis
Classification System (HFACS) Applied to
Health Care Am J Med Qual
201429181-190
20 Carayon P Xie A Kianfar S Human
factors and ergonomics as a patient safety
practice BMJ Qual Saf 201423196-205
21 Reason J Human Error New York
Cambridge University Press 1990
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 104
TABLE
Table 1 Incidences by Category (N=40)
CategorySAC SAC 4 SAC 3 SAC 2 SAC 1 total
Laboratory and ex-
amination events
4 10 2 0 16 (400)
Clinical care event 6 2 1 0 9 (225)
Medication event 5 0 2 0 7 (175)
Surgery-related event 1 1 2 0 4 (100)
Transfusion-related
event
1 1 0 0 2 (50)
Tube event 0 1 0 0 1 (25)
Public accident 0 0 1 0 1 (26)
Total 17 (425) 15 (375) 8 (200) 0 40 (100)
SAC 1113 Severity Assessment Code SAC
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 105
FIGURES
Figure 1 Active Failures (N=40)
16 (167)
66 (1000)
640 (150)
235 (57)
735 (200)
2435 (686)
2435 (686)
3540 (875)
438 (105)
438 (105)
738 (184)
1938 (500)
3138 (816)
3840 (950)
0 5 10 15 20 25 30 35 40
Commits WidespreadRoutine Violation
Performs Work-Around Violation
Ignored a CautionWarning
Failure to Prioritize Tasks Adequately
Wrong Choice of Action During an Operation
Inadequate Real‐Time Risk Assessment
Rushed or Delayed a Necessary Action
Breakdown in Visual Scan
Over-ControlledUnder-Controlled AircraftVehicleSystem
Unintended Operation of Equipment
Procedure Not Followed Correctly
Performance-Based Errors
Judgment and Decision Making Errors
Violations
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 106
Figure 2 Preconditions (Latent Failures or Conditions) (N=40)
14 (250)
24 (500)
48 (500)
11 (1000)
18 (125)
840 (200)
0 5 10 15 20 25 30 35 40
Seat and Restraint System Problems
Instrumentation amp Warning System Issues
Noise Interference
Environment
Physical Environment
Technological Environment
27 (286)
27 (286)
27 (286)
37 (129)
47 (511)
47 (571)
77 (1000)
24 (500)
44 (1000)
47 (571)
12 (500)
22 (1000)
27 (286)
740 (175)
0 5 10 15 20 25 30 35 40
Technical or Procedural Knowledge Not Retained After Training
InterferenceInterruption
Task OverUnder Saturation
Distraction
Negative Habit Transfer
Not Paying Attention
Complacency
Overconfidence
Physical IllnessInjury
Fatigue
Physical and Mental State
Physical Problem
State of Mind
Mental Awareness
211 (182)
311 (273)
311 (273)
411 (364)
811 (7227)
911 (818)
1140 (275)
0 5 10 15 20 25 30 35 40
Inadequate Task Delegation
TaskMission PlanningBriefingDebriefing Inadequate
Failure of CrewTeam Leadership
StandardProper Terminology Not Used
Critical Information Not Communicated
Failed to Effectively Communicate
Teamwork
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 107
Figure 3 Supervision (Direct Supervisory Chain of Command) (N=40)
Figure 4 Organization Influence (Upper-Level Management Command Level) (N=40)
114 (71)
114 (71)
214 (143)
314 (214)
1314 (929)
1440 (350)
511 (455)
511 (455)
711 (636)
1140 (275)
47 (571)
67 (857)
740 (175)
0 5 10 15 20 25 30 35 40
Selected Individual with Lack of Proficiency
Improper Role‐modeling
Failed to Provide Proper Training
Failed to IdentifyCorrect Risky or Unsafe Practices
SupervisoryCommand Oversight Inadequate
Performed Inadequate Risk Assessment ‐Formal
Selected Individual with Lack of Current or Limited Experience
Authorized Unnecessary Hazard
Allowing Unwritten Policies to Become Standard
Failure to Enforce Existing Rules
Supervisory Violations
Planned Inappropriate Operations
Inadequate Supervision
12 (500)
12 (500)
240 (50)
110 (100)
510 (500)
1040 (250)
11 (1000)
140 (25)
18 (125)
18 (125)
38 (35)
48 (500)
840 (200)
0 5 10 15 20 25 30 35 40
Organizational Over-confidence or Under-confidence in Equipment
Organizational Culture (attitude actions) Allows for Unsafe TaskMission
Purchasing or Providing Poorly Designed or Unsuitable Equipment
Organizational ProgramPolicy Risks not Adequately Assessed
Failure to Provide Adequate Manning Staffing Resources
Failure to remove inadequate worn-out equipment in timely manner
Inadequate infrastructure
Command and control resources are deficient
Failure to provide adequate operational information resources
Resource Problems
Personnel Selection amp Staffing
Policy and Process Issues
ClimateCulture Influences
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 108
Supplement Table 1- HFACS Content of Human Factor Analysis Classifi-
cation System [9] Tier main level sub-item nano code
Tier 1 Unsafe Acts
Perfor-
mance-Based
Errors
Unintended operation of equipment
Checklist not followed correctly
Procedure not followed correctly
Over-controlledunder-controlled aircraftvehiclesystem
Breakdown in visual scan
Rushed or delayed a necessary action
Judgment amp De-
cision-Making
Errors
Inadequate real‐time risk assessment
Failure to prioritize tasks adequately
Ignored a cautionwarning
Wrong choice of action during an operation
Violations
Performs work-around violation
Commits widespreadroutine violation
Extreme violation-lack of discipline
Tier 2 Preconditions
Environment
Physical environment
Environmental conditions affecting vision
Vibration effects vision or balance
Heatcold stress impairs performance
External force of object impeded an individualrsquos
movement
Lights of other vehiclevesselaircraft affected vision
Noise interference
Technological environment
Seat and restraint system problems
Instrumentation amp warning system issues
Visibility restrictions (not weather related)
Controls and switches are inadequate
Automated system creates unsafe situation
Workspace incompatible with operation
Personal equipment interference
Communication equipment inadequate
Physical and
Mental State
Physical problem
Substance effects (alcohol supplements medications
drugs)
Loss of consciousness (sudden or prolonged onset)
Physical illnessinjury
Fatigue
Inadequate adaptation to darkness
Dehydration
Body sizemovement limitations
Physical strength amp coordination (inappropriate for
task demands)
Nutritiondiet
State of mind
Psychological problem
Life stressors
Emotional state
Personality style
Overconfidence
Fu-Jen Journal of Medicine Vol 3 No 2 2020
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Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 109
Pressing
Complacency
Motivation
Motivational exhaustion (burnout)
Sensory misperception
Motion illusion-kinesthetic
Turning illusionbalance-vestibular
Visual illusion
Misperception of changing environment
Misinterpreted misread instrument
Misinterpretation of auditorysound cues
Spatial disorientation
Temporaltime distortion
Mental awareness
Not paying attention
Fixation
Task overunder saturation
Confusion
Negative habit transfer
Distraction
Geographically lost
Interferenceinterruption
Technical or procedural knowledge not retained after
training
Inaccurate expectation
Teamwork
Failure of crewteam leadership
Inadequate task delegation
Rankposition intimidation
Lack of assertiveness
Critical information not communicated
Standardproper terminology not used
Failed to effectively communicate
Taskmission planningbriefingdebriefing inadequate
Tier 3 Supervision
Supervisory Vio-
lations
Failure to enforce existing rules
Allowing unwritten policies to become standard
Directed individual to violate existing regulations
Authorized unqualified individuals for task
Planned Inappro-
priate Operations
Directed task beyond personnel capabilities
Inappropriate team composition
Selected individual with lack of current or limited experience
Performed inadequate risk assessment ‐formal
Authorized unnecessary hazard
Inadequate Su-
pervision
Supervisorycommand oversight inadequate
Improper role‐modeling
Failed to provide proper training
Failed to provide appropriate policyguidance
Personality conflict with supervisor
Lack of supervisory responses to critical information
Failed to identifycorrect risky or unsafe practices
Selected individual with lack of proficiency
Tier 4 Organizational
Influences
Resource Prob-
lems
Command and control resources are deficient
Inadequate infrastructure
Fu-Jen Journal of Medicine Vol 3 No 2 2020
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Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 110
Failure to remove inadequate worn-out equipment in timely
manner
Failure to provide adequate operational information resources
Fail to provide adequate funding
Personnel Selec-
tion amp Staffing
Personnel recruiting amp selection policies are inadequate
Failure to provide adequate manning staffing resources
Policy amp Process
Issues
Pace of ops-tempoworkload
Organizational programpolicy risks not adequately assessed
Provided inadequate procedural guidance or publications
Organizational (formal) training is inadequate or unavailable
Flawed doctrinephilosophy
Inadequate program management
Purchasing or providing poorly designed or unsuitable equip-
ment
ClimateCulture
Influences
Organizational culture (attitude actions) allows for unsafe
taskmission
Organizational over-confidence or under-confidence in equip-
ment
Unit missionaircraftvehicleequipment change or unit deacti-
vation
Organizational structure is unclear or inadequate
Fu-Jen Journal of Medicine Vol 3 No 2 2020
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Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 111
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
以 HFACS重新檢視根本原因分析案例挖掘造成醫療不良
事件之人為因素
鄭伃洵 1洪聖惠 12柯彤文 3王拔群 14
中文摘要
背景醫療不良事件(AMEs)的管理是促進病人安全的基石根本原因分析
(RCA)是探討重大病人安全不良事件問題但是由於無法解釋更廣泛的因素而受
到限制本研究使用人為因素分類與分析工具(HFACS)回溯審視醫療不良事件
以了解影響醫療不良事件的人為因素及各層面中錯誤原因之分佈或系統性問題
方法本研究回溯 2012-2016年間有做過根本原因分析之醫療不良事件以連續
性取樣方式(continuous sampling)收集 40例醫療不良事件以人為因素分類與分
析工具(HFACS)去系統性的挖掘每件案例發生錯誤之原因結果在行為層面中
分析結果主要為基礎技能錯誤(95)判斷和決策錯誤(875)其中在基礎技能
錯誤當中以未依程序作業執行(816)及未如預期設備操作(50)佔多數判斷和
決策錯誤中以現場風險評估不確實(686)及採取錯的步驟行為(686)佔多數
而在先決條件層面中以團隊合作(275)為主要因素包含溝通不良(818)及重
要訊息未以正確的方式即時傳達(727)佔多數在監督層面當中以監督不周
(929)或監督不妥當(929)為主要因素在組織政策和流程方面(50)以組織
系統的政策風險未充分評估(35)為主要因素結論本研究進一步了解醫療不
良事件在過去使用根本原因分析未探討到的人為因素反映出潛在的監督組織
行為或系統性的問題促進病人安全預防錯誤再發生
關鍵字病人安全醫療不良事件根本原因分析人為因素
1國泰醫療財團法人國泰綜合醫院 品質管理部
2國立臺灣大學健康政策與管理研究所
3振興醫療財團法人振興醫院 醫療品質管理中心
4輔仁大學醫學院
通訊作者王拔群 電子信箱 drtonyseednettw
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin 112
Submitted January 20 2020
Final version accepted April13
2020
Case Report
Juvenile Caruncular Atypical Lymphoid
Proliferation ndash A Rare Case Report
Cite as Hua-Wei Shih Yu-Chi Lin
Juvenile Caruncular Atypical
Lymphoid Proliferation ndash A Rare
Case Report Fu-Jen Journal of
Medicine 3(3) 112-119 2020
DOI
103966181020932020091803003
Hua-Wei Shih1 Yu-Chi Lin
1
1Department of Ophthalmology Shin Kong Wu Ho-Su Memorial Hos-
pital Taipei City Taiwan
Corresponding author E-mail address
yuchi067gmailcom (Yu-Chi Lin)
ABSTRACT
Lesions of the caruncle are very rare Most caruncular lesions are benign though there were still few reported malignant lesions Ocular adnexal lymphoproliferative disease (OALD) one of the differential diagnosis of caruncular lesion is seldom seen in young pa-tient In this article we report a 16-year-old boy with recurrent caruncular atypical lym-phoid proliferation We discuss the epidemiology clinical features images histomorpholo-gy and treatment between ocular adnexal lymphomas (OAL) and reactive lymphoid hyper-plasia (RLH)
Keywords caruncular lesion ocular adnexal lymphoproliferative disease ocular adnexal lymphoma
reactive lymphoid hyperplasia atypical lymphoid proliferation
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
113
INTRODUCTION Lesions of the caruncle are very rare Differen-
tial diagnosis includes nevus myeloproliferative
disorders tumors inflammation infection cysts
vascular lesions and fibrous Biopsy is essential
for diagnosis Levy J et al reported ocular ad-
nexal lymphoproliferative disease (OALD) was
relatively uncommon diagnosis among caruncu-
lar lesions [1]
OALD was seldom described in Asian popula-
tion especially for young age C-Y Cheng re-
ported age-standardized incidence of ocular
adnexal lymphomas (OAL) in Taiwan from 1979
to 1996 was below 07 per million per year and
mean age was 531 years old [2] In 2015 five
Taiwanese cases of OAL whose age ranging
from 45 to 64 were presented [3] However
there were few cases of conjunctival OAL or
RLH in Chinese pediatric patient
Here we present a case of 16-year-old boy with a
caruncular mass at his left eye with recurrence
one month after excision We describe his clini-
cal symptoms photographs pathological results
management and follow-up clinical course in
this report
CASE REPORT A 16-year-old healthy boy presented a mass
lesion at his left eye caruncle accompanied with
the symptom of tearing for one month (Figure 1)
He had no ocular pain no itchiness no blurred
vision no night sweating no fever and no body
weight loss The patient denied systemic diseas-
es and histories of surgery His bilateral best
corrected visual acuity (BCVA) were 66 and
intraocular pressure (IOP) were both within
normal range There were no remarkable find-
ings for his cornea lens fundus and physical
examination Excision was performed and the
mass was soft with fluid inside therefore con-
junctival pyogenic cyst was our initial diagnosis
However one month after the excision a pro-
truding mass recurred at the patientrsquos nasal can-
thus of left eye (Figure 2) There were some
differences compared to previous condition At
the first time the soft mass was contained in a
well-defined cyst wall which more favored py-
ogenic granulation However after short period
of recurrence solid consistency and unclear
margin were found which favored malignancy
Besides the mass partially involved beyond the
gray line of nasal part lower eyelid whereas last
time the cyst mainly extended from conjunctiva
of caruncle The second excisional biopsy was
performed Pathologic examination demonstrat-
ed abundant atypical lymphoid proliferation
(Figure 3A 3B) Immunohistochemical studies
showed that the lymphoid aggregation was
composed predominantly of CD20-positive cells
(Figure 3C) focal positive staining of CD3
(Figure 3D) CD5 CD23 CD10 and negative
staining of cyclin-D1 Unfortunately the cellular
morphology was difficult to be evaluated due to
marked crushing artifact Thus malignant lym-
phoma cannot be excluded totally
Orbital computed tomography (CT) showed a
lesion of soft tissue density at medial canthus of
left orbit without obvious nasolacrimal duct or
bony invasion (Figure 4A) Magnetic resonance
imaging (MRI) with contrast showed strong
enhancement at left medial canthus region (Fig-
ure 4B) There was no remarkable finding in the
systemic workup including complete blood
count and differential count biochemical pro-
files and 18F-fluoro-2-deoxyglucose positron
emission tomographycomputed tomography
(18F-FDG PETCT) indicating no evidence of
systemic involvement
After the second excision we preferred con-
servative management for him due to the uncer-
tainty of malignancy and to avoid side effects
from aggressive treatment No sign of recurrence
was noted after 10 months of observation The
follow-up photo was taken at three months after
the second operation (Figure 5)
DISCUSSION Ocular adnexal lymphoproliferative disease
(OALD) consists of the spectrum of lymphoid
disease affecting the tissues surrounding the eye
including ocular adnexal lymphomas (OAL) and
lymphoid hyperplasia (LH) [4] The conjunctiva
is an important location for extranodal lympho-
ma development which comprises 25 of OAL
[5]
OAL can be grouped into two categories based
on their appearance of cells under the micro-
scope low-grade and high-grade [6] Extranodal
marginal zone lymphoma of mucosa-associated
lymphoid tissue (EMZLMALT) is the most
common subtype of OAL followed by follicular
lymphoma [7-9] Both of the above are
low-grade lymphomas
LH can be further divided by histopathology into
reactive lymphoid hyperplasia (RLH) and atypi-
cal lymphoid hyperplasia (ALH) RLH has to-
tally benign morphology and immunophenotype
whereas ALH has borderline lesions between
RLH and lymphoma [10] OAL and LH are
mostly seen in patients with age between 50-70
years old There are rare cases in pediatric group
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
114
[71011] In the C-Y Chengrsquos statistical report of
OAL in Taiwan only 8 patients were younger
than 15 years old among the 101 cases of ocular
lymphoma [2] According to an US study inci-
dence rates of OAL were analyzed in different
age groups the group of age over 50 had the
highest incidence rate of 574 per million per-
son-years while the 0-19 age group had the
lowest incidence rate of 009 per million per-
son-years [12] The incidence of LH was even
less than OAL [13]
Patients with OALD may be asymptomatic or
with symptoms of proptosis eyelid swelling a
palpable painless mass or conjunctival salmon
patch Diplopia visual loss pain or inflamma-
tion occurred less frequently implying more
aggressive features [714]
Orbital LH is not distinguishable from low-grade
lymphoma radiologically They both typically
present a round or lobulated mass that diffusely
moderately enhances with contrast and usually
shows homogenous hypointense or isointense to
muscle barely invasion to bone or nervous sys-
tem [10] Atypical appearances including inho-
mogeneous calcification or bony changes may
be seen in high-grade lymphoma case reports
such as ocular adnexal diffuse large B-cell lym-
phoma (DLBCL) which is one of the more ag-
gressive type of OAL [7] Whole body PET is
used for not only the evaluation of systemic
involvement but also the standard for staging
lymphoma Our patientrsquos image studies revealed
neither obvious local invasion nor systemic ma-
lignancy indicating high-grade lymphoma was
less likely Low-grade lymphoma and benign
reactive lymphoid hyperplasia were still under
consideration
Histomorphology analysis and immunohisto-
chemistry (IHC) are essential for diagnosis
Flow cytometry and polymerase chain reaction
(PCR) technique are also applied to help differ-
entiate from RLH and OAL [1016] Our case
had immunohistochemical profile of positivity
for CD20 predominantly positivity focally for
CD3 CD5 CD10 CD23 and negativity for cy-
clin-D1 BCL-6 staining was not performed in
our casersquos biopsy Thus according to the IHC
report RLH ALH and follicular lymphoma are
probable diagnosis of our patient
Radiation therapy is the standard treatment for
low-grade OAL that is classified as T1N0M0 or
T2N0M0 according to the AJCC criteria [15]
İncesoy-Ouml zdemir S et al reported a 10-year-old
boy diagnosed of MALT lymphoma who was
treated with local radiotherapy (36 Gy) and
there were no local or systemic recurrences dur-
ing his nearly four-year follow-up [17] Another
case report represented a 21-year-old man of
conjunctival follicular lymphoma treated with
surgical excision only showing no evidence of
recurrence after 8 months follow-up [18] Other
treatment options for pediatric and juvenile OAL
were performed in some case reports including
intravenous rituximab intralesional interfer-
on-α-2b topical interferon a6 systemic doxycy-
cline surgical excision and postoperative local
cryotherapy [15]
Treatment for young conjunctival RLH was less
discussed in the past In a case series article
three children (9 13 14 years old respectively)
of RLH received surgical resection without fur-
ther postoperative management and no signs of
recurrence were noted during follow-up [19]
Short-term topical and oral corticosteroids after
surgical excision were prescribed in two pediat-
ric RLH patients for their small residual mass
However poor response in both cases was nota-
ble [20]
Our patient declined to receive radiotherapy or
any further postoperative treatment mainly due
to his concerning of possible side effects (such
as dry eye and cataract)
CONCLUSION We present a rare case of caruncle mass in this
report OALD is one of the relatively uncommon
diagnosis among caruncular lesions OALD
includes benign RLH and malignant OAL
which are both mainly seen in elderly patients
even rarer in pediatric or juvenile group
The standard treatment for low-grade OAL and
RLH in young patents are still debatable How-
ever long-term follow-up is suggested for both
OAL and RLH patients Though RLH has a be-
nign and self-limited course risk of malignant
transformation is possible
REFERENCES 1 Levy J Ilsar M Deckel Y et al Lesions of
the caruncle a description of 42 cases and
a review of the literature Eye
200923(5)1004-1018
2 C-Y Cheng and W-M Hsu Incidence of
eye cancer in Taiwan an 18-year review
Eye 200418152-158
3 Chui-Lien Tsen Muh-Chiou Lin
Youn-Shen Bee et al Ocular adnexal
lymphoma Five case reports and a
literature review Taiwan Journal of
Ophthalmology 20155(2)99-102
4 Liesegang TJ Ocular adnexal
lymphoproliferative lesions Mayo Clin
Proc 199368(10)1003-1010
5 Kirkegaard MM Coupland SE Prause JU
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
115
et al Malignant lymphoma of the
conjunctiva Surv Ophthalmol
201560(5)444-458
6 Stacy RC Jakobiec FA Schoenfield L et
al Unifocal and multifocal reactive
lymphoid hyperplasia vs follicular
lymphoma of the ocular adnexa Am J
Ophthalmol 2010150(3)412-426
7 Sullivan TJ Ocular Adnexal
Lymphoproliferative Disease In Guthoff
RF Katowitz JA eds Oculoplastics and
Orbit Berlin Heidelberg Springer
20101-19
8 White Valerie A Understanding and
Classification of Ocular Lymphomas
Ocular Oncology and Pathology
20195379-386
9 Stefanovic A Lossos IS Extranodal
marginal zone lymphoma of the ocular
adnexa Blood 2009114(3)501-510
10 Andrew NH Coupland SE Pirbhai A et al
Lymphoid hyperplasia of the orbit and
ocular adnexa A clinical pathologic review
Surv Ophthalmol 201661(6)778-790
11 Ferry JA1 Fung CY Zukerberg L et al
Lymphoma of the ocular adnexa A study
of 353 cases Am J Surg Pathol
200731(2)170-184
12 WM Hassan MS Bakry HM Hassan et al
Incidence of orbital conjunctival and
lacrimal gland malignant tumors in USA
from Surveillance Epidemiology and End
Results 1973-2009 Int J Ophthalmol
20169(12)1808-1813
13 Ajay A Rao John H Naheedy James Y-Y
Chen et al A Clinical Update and
Radiologic Review of Pediatric Orbital
and Ocular Tumors Journal of Oncology
2013(9)975908
14 Sullivan TJ Whitehead K Williamson R
et al Lymphoproliferative disease of the
ocular adnexa a clinical and pathologic
study with statistical analysis of 69
patients Ophthal Plast Reconstr Surg
200521177-188
15 Tanenbaum RE Galor A Dubovy SR et al
Classification diagnosis and management
of conjunctival lymphoma Eye Vis (Lond)
2019622
16 Olga Klavdianou Georgios Kondylis
Vasileios Georgopoulos et al Bilateral
benign reactive lymphoid hyperplasia of
the conjunctiva a case treated with oral
doxycycline and review of the literature
Eye Vis (Lond) 2019626
17 İncesoy-Ouml zdemir S Yuumlksek N Bozkurt C
et al A rare type of cancer in children
extranodal marginal zone B-cell (MALT)
lymphoma of the ocular adnexa Turk J
Pediatr 201456(3)295-298
18 Lynn J Poole Perry Frederick A Jakobiec
Peter A D Rubin Conjunctival Pediatric
Follicular Lymphoma Arch Ophthalmol
2012130(7)941-943
19 Abdullah Al-Mujaini Upender Wali
Anuradha Ganesh1 et al Ocular Adnexal
Reactive Lymphoid Hyperplasia in
Children Middle East Afr J Ophthalmol
201219(4)406-409
20 McLeod SD Edward DP Benign
lymphoid hyperplasia of the conjunctiva in
children Arch Ophthalmol
1999117(6)832-835
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
116
FIGURES
Figure 1 Slit lamp image of a mass lesion at the patientrsquos left eye caruncle for one month
Figure 2 One month after the first excision a protruding mass recurred at the patientrsquos nasal canthus
of left eye It partially involved beyond the gray line of nasal part lower eyelid
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
117
Figure 3 Histomorphology analysis and immunohistochemistry study of the caruncular lesion Abun-
dant atypical lymphoid proliferation presented in low-power photomicrograph (A) and
high-power photomicrograph (B) under hematoxylin-eosin staining The lymphoid aggrega-
tion was composed predominantly of CD20-positive cells (C) and focal positive staining of
CD3 (D)
Figure 4 Non-contrast orbital computed tomography showed a lesion of soft tissue density at medial
canthus of left orbit without obvious nasolacrimal duct or bony invasion (A) Magnetic reso-
nance imaging with contrast showed strong enhancement at left medial canthus region (B)
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
118
Figure 5 The follow-up photo were taken at three months after the second excision showing no signs
of recurrence
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
119
Juvenile Caruncular Atypical Lymphoid Proliferation ndash A Rare Case Report
罕見病例報告mdash青少年之淚阜非典型淋巴增生
施驊瑋 1林友祺 1
中文摘要
淚阜病灶相當罕見大部分為良性病灶眼睛及附屬結構淋巴增生疾病為其
鑑別診斷之一非常少見於年輕人或兒童我們報告一位 16歲的健康男性因
左眼淚阜無痛性腫塊接受切除手術卻於術後一個月復發執行第二次切除手術
後門診追蹤十個月未再復發此案例表現了部分良性與部分惡性腫瘤的特徵
我們針對反應性淋巴增生眼睛及附屬結構淋巴癌兩個疾病做討論及文獻回顧
關鍵字淚阜病灶眼睛及附屬結構淋巴增生疾病眼睛及附屬結構淋巴癌反
應性淋巴增生非典型淋巴增生
1 新光吳火獅紀念醫院眼科
通訊作者林友祺 電子信箱 yuchi067gmailcom
Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh 120
Submitted March 26 2020
Final version accepted April 16
2020
Case Report
Hyperacute intramembranous hemor-
rhage after burr hole craniostomy for
chronic subdural hematoma
Cite as Meng-Chi Lin Jui-Ming
Sun Yu-Hao Chen Cheng-Ta
Hsieh
Hyperacute intramembranous
hemorrhage after burr hole crani-
ostomy for chronic subdural he-
matoma Fu-Jen Journal of Medi-
cine 3(4) 120-125 2020
DOI
103966181020932020091803004
Meng-Chi Lin1 Jui-Ming Sun23 Yu-Hao Chen24 Cheng-Ta
Hsieh567
1Department of Surgery Zuoying Branch Kaohsiung Armed Forces
General Hospital Kaohsiung 813 Taiwan 2Section of Neurosurgery Department of Surgery Chia-Yi Christian
Hospital Chia-Yi City 600 Taiwan 3Department of Biotechnology Asia University Taichung City 41354
Taiwan 4Chung-Jen Junior College of Nursing Health Sciences and Manage-
ment Chia-Yi Country 62241 Taiwan 5Division of Neurosurgery Department of Surgery Sijhih Cathay Gen-
eral Hospital New Taipei City 22174 Taiwan 6Department of Medicine School of Medicine Fu Jen Catholic Univer-
sity New Taipei City 24205 Taiwan 7Department of Neurological Surgery Tri-Service General Hospital
National Defense Medical Center Taipei 114 Taiwan
Corresponding author E-mail address
nogormail2000comtw (Cheng-Ta Hsieh)
ABSTRACT
Burr hole craniostomy with closed-system drainage is an effective and common neurosurgical procedure to manage chronic subdural hematoma Postoperative hem-orrhage a well-known but infrequent complication may result in increased neurolog-ical deficits However hyperacute intramembranous hemorrhage within the inner and outer membrane of hematoma after burr hole craniostomy with irrigation and closed-system drainage has not been described previously Herein we report a case of postoperative spontaneous hyperacute intramembranous hemorrhage after burr hole craniostomy with closed-system drainage to manage a chronic subdural hematoma we subsequently discuss the possible pathophysiological mechanisms and review the relevant literature
Keywords Chronic subdural hematoma acute subdural hematoma bleeding burr hole craniostomy
drainage
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Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh
125
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
慢性硬腦膜下出血進行鑽顱引流手術造成超急性夾膜內出
血
林孟楫 1孫瑞明 23陳昱豪 24謝政達 567
中文摘要
鑽顱併封閉系統引流手術是治療慢性硬腦膜下出血患者一種有效且常見的
神經外科手術方式術後出血可能導致神經功能缺損惡化是眾所周知但不常見
的併發症之一然而至今仍未有鑽孔併封閉系統引流造成原本慢性硬腦膜血
塊內膜和外膜間急性夾膜間出血案例在這裡我們報告一例慢性硬腦膜下出
血病患者接受鑽顱併封閉系統引流手術治療造成術後急性夾膜間出血我們在
本文中討論可能的致病機制並回顧相關文獻
關鍵字慢性硬腦膜下出血急性硬腦膜下出血出血鑽顱術引流
1國軍高雄總醫院左營分院 外科部
2崇仁醫護管理專科學校
3亞洲大學 生物科技學系
4戴德森醫療財團法人嘉義基督教醫院 外科部 神經外科
5汐止國泰綜合醫院 神經外科
6輔仁大學 醫學系
7 國防醫學院 三軍總醫院 神經外科
通訊作者謝政達 電子信箱 nogormail2000comtw
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
126
Submitted January 21 2020
Final version accepted July 08
2020
Case Report
Hamartoma of the breast A case report
Cite as Hsuan-An Chen
Cheng-Yu Lo Shih-Hung Huang
Chin-Lung Lin
Hamartoma of the breast A case
report Fu-Jen Journal of Medicine
3(5) 126-130 2020
DOI
103966181020932020091803005
Hsuan-An Chen1 Cheng-Yu Lo
3 Shih-Hung Huang
3 Chin-Lung
Lin2
1Department of Surgery Cathay General Hospital Taipei Taiwan
2Department of General Surgery Cathay General Hospital Taipei Tai-
wan
3Department of Pathology Cathay General Hospital Taipei Taiwan
Corresponding author E-mail address
lungyungmailcom (Chin-Lung Lin)
ABSTRACT
Breast hamartoma is an uncommon benign tumor rarely associated with malignancy An
excision and histological examination is necessary for the differential diagnosis We report
a case of a 49-year-old female patient presenting with a lump in the right breast Ultrasound
examination which demonstrated a 4411 cm hypoechoic lesion with lipoma Partial mas-
tectomy was arranged and the diagnosis of a hamartoma was confirmed by the histological
examination
Keywords Breast tumor Hamartoma Ultrasound
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
127
INTRODUCTION The hamartoma is a benign tumor-like lesion
that can affect various organs of the body in-
cluding lungs kidneys skin and more rarely the
breast In 1981 the hamartomas were recognized
in the WHO classification[1] They are defined
as well-demarcated mass of mammary ducts and
lobules containing varying amounts of fibrous
and adipose tissue and producing a distinctive
mammographic image
CASE REPORT A 49 year-old female had past history of left
breast mastitis with abscess status post partial
mastectomy This time she presented to our out
patient clinic for breast examination Physical
examination revealed a painless palpable mova-
ble and painless lump at upper outer quadrant of
right breast The risk of breast cancer was not
noted and the patient did not have any family
history of breast cancer The patient also denied
any trauma history before Ultrasound examina-
tion was arranged which demonstrated a 4411
cm hypoechoic lesion with lipoma at 3 oclock 2
cm from nipple of right breast and multiple hy-
poechoic nodules of various size in both breasts
and there was no suspicious axillary lymph
nodes noted (Figure1) Surgical treatment was
arranged partial mastectomy of right breast
harmartoma was successfully performed A 32 x
31 x 21 cm tumor was completely excised
Grossly examination showed a gray to yellow
and firm to fatty The diagnosis of a hamartoma
was confirmed by the histological examination
Microscopically sections of the breast lesion
show mammary hamartoma composed of ducts
lobules with interlobular fibrous tissue and adi-
pose tissue Fibrocystic change apocrine meta-
plastic ducts and scattered foci of adenosis are
noted The overall lobulocentric architecture and
the 2-cell pattern of the epithelium are preserved
columnar cell change and focal microcalcifica-
tion are present (Figure2) Based on submitted
biopsy specimen in-situ or invasive tumor cells
are not identified
DISCUSSION Hamartoma of the breast is a benign tumor like
nodule it was also known as fibroadenolipoma
lipofibroadenoma or adenolipoma based on its
predominant components It was composed of
varying amounts of glandular adipose and fi-
brous tissue[2] Hamartomas were first described
in 1971 by Arrigoni et al in a study of 10 patients
which breast tumors clinically and grossly re-
sembled fibroadenomas[3]
A higher predominance of tumors exists in fe-
males compared with males Hamartomas are
slowly-growing lesions with the diameter rang-
ing from 2 cm to 5 cm sometimes hamartomas
can reach giant diameter [4]
The clinical diagnosis of hamartoma is based on
the findings from mammography sonography
and histology examinations The hamartomas are
usually incidentally diagnosed by the women
older than 40 year-old starting mammography
screening
On physicial examination harmatomas are usu-
ally occult painless they may be as large mo-
bile soft to firm masses[5] Ultrasound showed
well capsulated mass with echogenic rim and
internal heterogeneity Mammography exam
showed well-circumscribed round to oval
masses containing fat and soft tissue densities
with a thin radiopaque pseudocapsule The
pseudocapsule results from displacement of
breast parenchyma by the tumor [56] In Pa-
thology finding microglandular adenosis is pre-
sent in fibroadipose stroma surrounded by a thin
fibrous capsule It composed of a combination of
epithelial and stromal elements usually with
normal ducts or lobules although variations of
normal tissue may also be seen Fibroadenoli-
poma myoid hamartoma and chondrolipoma are
histological variations of hamartomas depend-
ing on the proportion of normal breast tissue
elements[7]
Malignancy associated with hamartomas are
very rare[8] However it has been reported
hamartomas develop into carcinoma Malignant
transformation can occur as a result of cellular
atypia in the epithelial component of the mass[9]
Surgical removal is the curative method for
breast hamartomas[10] Diagnostic material such
as mammography ultrasonography or core nee-
dle biopsy may not give the definitive diagnosis
Therefore surgical excision and histological
examination is necessary for differential diagno-
sis[111213]
Although it is rare hamartoma can be seen along
with malignancy as it is formed from similar
components of breast tissue Therefore careful
diagnosis and appropriate management including
surgery are required
REFERENCES 1 World Health Organization (1981)
Histological typing of breast tumors In
International histological classification of
tumors 1981 2nd ed
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
128
2 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11435ndash449
2006
3 ArrigoniMG DockertyMB JuddES
The identificationand treatment of
mammary hamartoma Surg Gynecol
Obstet1971 133 577-82
4 Sanal HT Ersoz N Altinel O Unal E Can
C Giant hamartoma of the breast Breast J
2006 12 84-85
5 Feder JM de Paredes ES Hogge JP
Wilken JJ Unusual breast lesions
radiologic-pathologic correlation
Radiographics 1999 19S11ndashS26
6 Murat A Ozdemir H Yildirim H Poyraz
AK Ozercan R Hamartoma of the breast
Australas Radiol 200751 Spec NoB37ndash
9
7 Fisher CJ Hanby AM Robinson L Millis
RR Mammary hamartoma-a review of 35
cases Histopathology 1992 20 99-106
8 Choi N Ko ES Invasive ductal carcinoma
in a mammary hamartoma case report and
review of the literature Korean J Radiol
2010 Nov-Dec11(6)687-91
9 Lee EH Wylie EJ Bourke AG Bastiaan
De Boer W Invasive ductal carcinoma
arising in a breast hamartoma two case
reports and a review of the literature Clin
Radiol 2003 58 80-3
10 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11 435 ‑449
2006
11 Coyne J Hobbs FM Boggis C Harland R
Lobular carcinoma in a mammary
hamartoma J Clin Pathol 199245936ndash
937
12 G M K Tse B K B Law T K F Ma A B W
Chan Hamartoma of the breast a
clinicopathological review J Clin Pathol
200255951ndash954
13 RAAmir SSheikh BreasthamartomaA
report of 14cases of an under-recognized
and under-reported entity International
Journal of Surgery Case Reports
22(2016)1ndash4
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
129
FIGURES
Figure 1 Ultrasound shows a 4411 cm hypoechoic lesion with lipoma at 3 oclock 2 cm from nipple
of right breast
Figure 2 Photomicrograph shows mammary hamartoma composed of ducts lobules with interlobular
fibrous tissue and adipose tissue
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
130
Hamartoma of the breast A case report
乳房錯構瘤罕見個案報告
陳宣安 1羅承裕 3黃世鴻 3林錦龍 2
中文摘要
乳房錯構瘤是一種罕見之乳房良性腫瘤切除手術及病理化驗來做鑑別診斷
我們報告一位 49歲女性以可觸摸到無痛性右側乳房腫塊為臨床表徵超音波
看到一個邊緣清楚低迴音的腫塊病患接受手術切除病灶病理診斷證實為乳
房錯構瘤
關鍵字乳房腫瘤錯構瘤超音波攝影
1國泰綜合醫院外科部
2國泰綜合醫院一般外科
3國泰綜合醫院病理科
通訊作者林錦龍 電子信箱 lungyungmailcom
Fu-Jen Journal of Medicine
Mission and Goals
The Fu-Jen Journal of Medicine (FJJM) is a peer-reviewed journal which
aims to enhance research quality of staffs in the College of Medicine Fu Jen
Catholic University The journal publishes original investigations across a
wide range of medical disciplines including original research articles in basic
and clinical sciences case reports review articles brief reports and letter
to the editor FJJM is now issued by the Center of Medical Education in the
College of Medicine Fu Jen Catholic University To promote journal quality
the manuscript submitted to FJJM after August first 2015 has to be prepared
in English to meet the international standards
Issue Date
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Institution
December 01 2003
September 30 2020
College of Medicine Fu Jen Catholic University
Honorable publisher Han-Sun Chiang
Publisher Ping-Keung Yip
Editor-in-chief Ming-Chieh Ma
Associate Editors Yu-Wen Lin
Editors
Telephone (02) 2905-3477
Address Center for Medical Education College of Medicine Fu Jen
Catholic University
No 510 Zhongzheng Rd Xinzhuang Dist New Taipei City
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Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang
99
Submitted October 11 2019
Final version accepted February
02 2020
Original Research Article
Human Factors Underlying Adverse
Medical Events Revisit Root Cause Anal-
ysis Cases Using the HFACS
Cite as Yu-Hsun Cheng
Sheng-Hui Hung Tung-Wen Ko
Pa-Chun Wang
Human Factors Underlying Ad-
verse Medical Events Revisit
Root Cause Analysis Cases Using
the HFACS Fu-Jen Journal of
Medicine 3(2) 99-111 2020
DOI
103966181020932020091803002
Yu-Hsun Cheng1 Sheng-Hui Hung
12 Tung-Wen Ko
3 Pa-Chun
Wang14
1Department of Quality Management Cathay General Hospital Taipei
Taiwan
2Institute of Health Policy and Management National Taiwan Universi-
ty Taipei Taiwan
3Center for Healthcare Quality Management Cheng Hsin General Hos-
pital Taipei Taiwan
4Fu Jen Catholic University School of Medicine New Taipei City Tai-
wan
Corresponding author E-mail address
drtonyseednettw (Pa-Chun Wang)
ABSTRACT Background Appropriate management of adverse medical events (AMEs) is the corner-
stone of patient safety Root cause analysis (RCA) is used to investigate serious or
high-frequency errors but is limited by its inability to explain a broader scope of factors
We re-reviewed RCA cases to understand the underlying human organizational or system-
ic factors affecting AMEs Methods A total of 40 consecutive RCA cases (2012-2016) were
retrieved from the AMEs database A panel was organized to retrospectively re-review these
cases using the Human Factor Analysis and Classification System HFACS Results For
active failures errors stemmed largely from performance-based (95) judgment and deci-
sion-making errors (875) Incorrectly followed procedures (816) and accidental
equipment operation (50) were the most common types of performance-based errors In-
adequate real-time assessment (686) and inappropriate operative actions (686) were
the most common decision-making errors For sources of latent failure teamwork problems
(275) including failure to effectively communicate (818) and communicate critical
information (727) were common Inadequate supervision (929) or command over-
sights (929) were the most common problems related to inadequate supervision (35)
Organizational programpolicy risks not adequately assessed (50) were the most common
problems related to policy and process problem (25) Conclusions The HFACS review
enhances our understanding of human factors underlying AMEs The HFACS reveals latent
supervisory organizational or systematic problems that cannot be addressed through tradi-
tional RCA Keywords patient safety adverse events root cause analysis human factors
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 100
INTRODUCTION Patient safety involves the reduction of patient
harm from potentially avoidable unintended
outcomes [1] Studies have revealed that 50ndash
80 of adverse medical events (AMEs) are pre-
ventable [2-4] to eliminate such errors the ap-
propriate management of AMEs hence repre-
sents the cornerstone of patient safety work
Through incident reporting investigation and
analysis healthcare providers can correct or
re-engineer their care processes to prevent inci-
dent recurrence [25] One of the most popular
tools for investigating AMEs is root cause anal-
ysis (RCA) RCA reconstructs a chain of errors
to identify the deviation of care from normal
processes Nonetheless with a lack of standard-
ized nomenclature and investigation procedures
RCA report conclusions are sometimes too sub-
jective and nonspecific to facilitate any actiona-
ble safety improvement plans [5-7] According
to the UK Health and Safety Executive defini-
tion human factors are environmental organiza-
tional occupational or individual human char-
acteristics which influence behavior at work
such that health and safety are affected [8] Hu-
mans and systems are prone to errors and stud-
ies have showed that nearly 70 of medical
errors involve human factors [2-4] Reasonrsquos
Swiss cheese model described the penetration of
causative human errors through layers of defen-
sive barriers leading to system collapse [9]
With much focus on the temporal sequence and
severity of departure from accepted practices in
an incident the effectiveness of RCA is often
challenged by its incapability of exploring un-
derlying human organization or even systemic
factors [5-7] Reason and others have proposed
that errors can occur at 4 levels 1) unsafe acts
(operator actions) 2) preconditions for unsafe
acts (environmental factors contributing to er-
rors) 3) inadequate supervision (management
actions affecting the operator) and 4) organiza-
tional influences (organizational culture policies
and procedures that affect the operator) [9]
Based on this theory Wiegmann and Shappell
developed the Human Factor Analysis Classifi-
cation System (HFACS) to describe human fac-
tors causing accidents from 4 tiers of categories
Each of these categories consists of nanocodes to
represent specific human behavior or system
problems leading to errors [9-10] The tier for
unsafe acts involves actual provider actions (er-
rors or rule violations) directly leading to events
The tier representing preconditions for unsafe
acts includes operational personnel and envi-
ronmental factors The supervision tier addresses
leadership problems operational planning fail-
ure or correction and supervisory ethics The
tier for organizational influences deals with re-
source management organizational climate and
operational processes (Supplement Table 1) The
HFACS provides standardized investigation
processes for the systematic analysis of common
causes of adverse events across national defense
nuclear power navy aviation and healthcare
industries Taiwan launched its nationwide
AME-reporting system the Taiwan Patient
Safety Reporting System (TPR) in 2004 RCA
methodology was subsequently introduced to the
healthcare industry by the Joint Commission of
Taiwan [11] Since 2012 appropriate manage-
ment of AMEs has been listed as a national pa-
tient safety goal [12] RCA is required by the
Ministry of Health and Welfare for major AMEs
Aside from RCA a comprehensive structural
reliable and valid framework is urgently re-
quired to further guide organizational or even
national patient safety policies In this study we
used the HFACS to review our RCA cases aim-
ing to investigate human factors underlying se-
vere or frequent AMEs
MATERIALS AND METHODS Through continuous sampling 40 consecutive
RCA cases (2012-2016) were retrieved from a
hospitalrsquos (Cathay General Hospital Taipei
Taiwan) AME-reporting system database The
database contains AMEs relating to areas such as
medication patient falls surgery transfusion
clinical care public accidents security hospital
violence tube-related complication unplanned
cardiopulmonary resuscitation laboratory testing
and examination and anesthesia The RCA cases
were sentinel or high-frequency events classified
according to severity assessment category (SAC)
[1113] The SAC is an evaluation method for
categorizing AMEs by severity of effect on pa-
tients health and risk of incident reoccurrence
The HFACS has been modified (from the US
Department of Defense version 70) and trans-
lated into Mandarin Chinese with authorization
from the original developers [10] The Chi-
nese-version HFACS for Taiwan is a valid in-
strument (content validity index 09 Cronbachrsquos
α gt07 interrater reliability Κ 04-10) equiva-
lent to the original English version [9] The
HFACS contains 4 tiers 13 subitems and 109
nanocodes (Supplement Table 1) A panel of 6
reviewers was established All reviewers were
from clinical or management (quality and patient
safety management) backgrounds Reviewers all
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 101
finished human factor education and were
trained to use the HFACS through a consensus
meeting Each RCA case was randomly assigned
to 2 reviewers Human factors leading to partic-
ular AMEs were identified and confirmed when
2 reviewers reached agreement The distribution
of errors among tiers subitems and nanocodes
are provided with descriptive statistics () The
study was approved by the Institutional Review
Board of Cathay General Hospital
(CGH-P105095)
RESULTS AMEs related to laboratory testing and examina-
tion (n = 16) clinical care (n = 9) and medica-
tion (n = 7) were the most commonly observed
in the RCA Most AMEs in this cohort are
ranked as being SAC level 3 (n = 15) or 4 (n =
17) (Table 1)
Acts (Active Failures)
This tier of errors contains 3 subitems and 13
nanocodes In the 40 RCA cases perfor-
mance-based errors for 38 (95) and judgment
and decision-making errors for 35 (875) com-
prised the most common error types with viola-
tion for 6 (15) less common Procedure fol-
lowed incorrectly for 31 out of 38 (816) was
the most common performance-based problem
Inadequate real-time risk management for 24 out
of 35 (686) was the most common judgment
or decision error All of the rule violations were
workaround types for 6 out of 6 (100) (Figure
1)
Preconditions(Latent Failures)
This tier of errors has 9 subitems and 58 nano-
codes In the 40 RCA cases teamwork for 11
(275) and environmental for 8 (20) factors
contributed to most of the errors with mental
and physical state the next most common factor
for 7 (175) Communication for 9 out of 11
(818) and information relay for 8 out of 11
(727) were the most common issues related to
teamwork Few contributors mentioned failures
related to technical errors for 4 (50) or physi-
cal for 1 (125) environment Not paying at-
tention for 4 out of 7 (571) and negative habit
transfer for 4 out of 7 (571) were common
mental contributes noted for 7 (100) Overcon-
fidence was the most common problem related
to emotional status for 4 out of 7 (571) Fa-
tigue was observed in only 2 cases for 2 out of 2
physical problems (100) (Figure 2)
Supervision(Direct Supervisory Chain of
Command)
This tier of errors contains 3 subitems and 17
nanocodes In the 40 RCA cases inadequate
supervision for 14 (35) and inappropriately
planned operations for 11 (275) factors con-
tributed to most of the respective errors fol-
lowed by supervisory violations for 7 (175)
Supervisory or command oversights for 13 out
of 14 (929) were the most common sources of
supervision inadequacy Authorized unnecessary
hazards for 7 out of 11 (636) were the most
common inappropriately planned operations
Failure to enforce rules for 6 out of 7 (857)
was the most common supervisory violation
(Figure 3)
Organization Influence (Upper-Level Man-
agement)
This tier of errors contains 4 subitems and 18
nanocodes In the 40 RCA cases policy and
process issues for 10 (25) and resources prob-
lem for 8 (20) were major concerns Few of
the respective problems are related to climate
and cultural influences for 2 (5) or to person-
nel selection and staffing for 1 (25) Poorly
assessed organizational programs or policy risks
for 5 out of 10 (50) were the most common
policy and process problems Failure to provide
adequate operational information resources for 4
out of 8 (50) and command and control re-
source deficiency for 3 out of 8 (375) were
the main resource management problems Little
was revealed regarding organizational climate
and culture (n = 1 out of 2 50) or staffing for 1
out of 1 (100) (Figure 4)
DISCUSSION Health care is a complex system comprising
many high-reliability organizations (HROs) The
vulnerability of HROs stems from the participa-
tion of multidisciplinary teams in the processes
along a variety of patient care timelines How-
ever humans and systems are inherently prone
to errors the appropriate management of AMEs
is acknowledged to be the cornerstone of patient
safety AMEs should be reported investigated
analyzed and handled appropriately[14] Theo-
retically by analyzing the pattern of key defects
providers can fix errors and re-engineer their
care processes to reduce the possibility of AME
recurrence Taiwan established its nationwide
TPR in 2004 so far 7000 health care facilities
have participated and the database has accumu-
lated more than 055 million AMEs[11] Infor-
mation generated from the TPR database can
improve patient safety at individual organiza-
tional or even national levels However despite
relentless efforts few substantial improvements
have been achieved in patient safety [15-17]
Since its introduction in Taiwan in 2006 the use
of RCA for AMEs has encountered some diffi-
culties 1) No structural and standardized
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 102
framework exists for investigation
cross-institution variability and interrater relia-
bility are often ignored 2) Conclusions are often
subjective and corrective recommendations are
less actionable relying on individual reviewersrsquo
professional backgrounds and their experiences
3) Much focus on event reconstruction and oper-
ator performance means that factors relating to
human behavior organizational culture and
system weakness are not comprehensively ad-
dressed [671718] Traditionally attempts to
improve patient safety in the health care industry
are largely reactive in nature identifying and
correcting errors in care processes [1920]
Causes of defects are not thoroughly understood
Proactive approaches must be taken to address
systematic problems within a complex system
[720] Research suggests that human error is a
causal factor in the occurrence of AMEs AME
investigation targets have moved from skill defi-
ciency toward decision-making attitudes super-
visory factors and even organizational climate
or culture HFACS methodology is based on the
Swiss cheese model that also emphasizes active
and latent failures [921] The study provides
some noteworthy findings First most AMEs as
expected involve active failures such as failure
to follow procedure accidental operation of
equipment inadequate real-time risk manage-
ment and inappropriate action These are all
sharp ends in classic RCA environment physi-
cal and mental factors are less prevalent This
proves that retrospectively determining addi-
tional causal factors is difficult when infor-
mation has not been collected during preliminary
investigation (Figure 1) Second team-
work-related problems particularly in relation to
communication and information relay are well
addressed This may be attributed to the dec-
ade-long institution-wide routine crew resource
management training in the respective research
hospital (Figure 2) Third the HFACS success-
fully reflects the importance of supervisory roles
in the occurrence of AMEs and this cannot be
overlooked (Figure 3) Fourth latent failures
especially in organizational climate or cultural
dimensions have been less frequently addressed
in incident reports a limitation of traditional
RCA However the HFACS review suggests
room for improvement in resource allocation and
policy modification within the hospital The
results of studies can make the organization
think about how to improve the patient safety
and management process from the perspective of
human factors such as improving the comfort of
the working environment and replacing and
equipment resources to prevent personnel from
affecting the medical quality and patient safety
due to the environment or equipment Need to
appropriate assessment of applicability and ade-
quate training of manpower is required The
management and control of risks should be fully
evaluate and grasp resource management and
leaders need to participate in and promote medi-
cal quality and patient safety activities to en-
hance its culture (Figure 4) No panacea exists
to ensure patient safety and improvement targets
originate largely from event investigation find-
ings Unfortunately factors identified from
AMEs are often self-explanatory with little value
for further action correction Reinforcement of
policy or processes redundant education or
repetitious training are formulaic overprescribed
RCA recommendations The use of HFACS in
this study proves that a structural prospective
AME investigation format can potentially help
with proactive patient safety management We
suggest developing an interview guideline for
the routine use of HFACS as a complement to
RCA in every AME investigation This study is a
retrospective study The underlying human fac-
tors can be under-estimated owing to the lack of
related information in the original RCA reports
CONCLUSION The HFACS review in this study enhances our
understanding of human factors in AMEs that
had previously been insufficiently scrutinized
Aside from active process and communication
errors the HFACS enables the prospective in-
vestigation of latent supervisory organizational
or systematic problems that cannot be addressed
through traditional RCA
REFERENCES 1 T Brennan L Leape N Laird et al
Incidence of adverse events and
negligence in hospitalized patients results
of the Harvard Medical Practice Study I N
Engl J Med 1991324370-376
2 Wang CH Shih CL Chen WJ et al
Epidemiology of medical adverse events
perspectives from a single institute in
Taiwan J Formos Med Assoc
2016115434-439
3 Vincent C Simon R Sutcliffe K et al
Errors Conference Executive Summary
Acad Emerg Med 200071180-1182
4 Taitz J Genn K Brooks V et al
System-wide learning from root cause
analysis A report from the New South
Wales Root Cause Analysis Review
Committee Qual Saf Health Care
2010191-5
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 103
5 Hutchinson A Young TA Cooper KL et
al Trends in healthcare incident reporting
and relationship to safety and quality data
in acute hospitals results from the
National Reporting and Learning System
Qual Saf Health Care 2009185-10
6 Mitchell RJ Williamson AM Molesworth
B et al A review of the use of human
factors classification frameworks that
identify causal factors for adverse events
in the hospital setting Ergonomics
2014571443-1472
7 Gurses AP Ozok AA Pronovost PJ Time
to accelerate integration of human factors
and ergonomics in patient safety BMJ
Qual Saf 201221347-351
8 Health and Safety Executive Introduction
to human factors
httpwwwhsegovukhumanfactorsintro
ductionhtm
9 Wiegmann DA Shappell SA A human
error approach to aviation accident
analysis The human factors analysis and
classification system Burlington VT
Ashgate Publishing Ltd 2003
10 Yu-Hsun Cheng Sheng-Hui Hung
Tung-Wen Ko et al An Analysis of the
Reliability and Validity of Human Factors
Analysis Classification System in Medical
Adverse Events Journal of Healthcare
Quality 20191370-76
11 Taiwan Joint Commission on Hospital
Accreditation Taiwan Patient-Safety
Reporting System Annual Report 2017
New Taipei City Taiwan
12 Taiwan Patient Safety Net
httpwwwpatientsafetymohwgovtwCo
ntentzMessagesslistaspxSiteID=1ampMm
mID=621273300317401756
13 Government of Western Australia
Department of Health
httpsww2healthwagovauArticlesS_T
Severity-assessment-codes
14 Farley DO Haviland A Champagne S et
al Adverse-event-reporting practices by
US hospitals results of a national survey
Qual Saf Health Care 200817416-423
15 Shojania KG Thomas EJ Trends in
adverse events over time why are we not
improving BMJ Qual Saf
201322273-277
16 Levitt P Challenging the systems approach
why adverse event rates are not improving
BMJ Qual Saf 2014231051-1052
17 Kellogg KM Hettinger Z Shah M et al
Our current approach to root cause
analysis is it contributing to our failure to
improve patient safety BMJ Qual Saf
201726381-387
18 Khorsandi M Skouras C Beatson K et al
Quality review of an adverse incident
reporting system and root cause analysis of
serious adverse surgical incidents in a
teaching hospital of Scotland Patient Saf
Surg 2012621
19 Diller T Helmrich G Dunning S et al
The Human Factors Analysis
Classification System (HFACS) Applied to
Health Care Am J Med Qual
201429181-190
20 Carayon P Xie A Kianfar S Human
factors and ergonomics as a patient safety
practice BMJ Qual Saf 201423196-205
21 Reason J Human Error New York
Cambridge University Press 1990
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 104
TABLE
Table 1 Incidences by Category (N=40)
CategorySAC SAC 4 SAC 3 SAC 2 SAC 1 total
Laboratory and ex-
amination events
4 10 2 0 16 (400)
Clinical care event 6 2 1 0 9 (225)
Medication event 5 0 2 0 7 (175)
Surgery-related event 1 1 2 0 4 (100)
Transfusion-related
event
1 1 0 0 2 (50)
Tube event 0 1 0 0 1 (25)
Public accident 0 0 1 0 1 (26)
Total 17 (425) 15 (375) 8 (200) 0 40 (100)
SAC 1113 Severity Assessment Code SAC
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 105
FIGURES
Figure 1 Active Failures (N=40)
16 (167)
66 (1000)
640 (150)
235 (57)
735 (200)
2435 (686)
2435 (686)
3540 (875)
438 (105)
438 (105)
738 (184)
1938 (500)
3138 (816)
3840 (950)
0 5 10 15 20 25 30 35 40
Commits WidespreadRoutine Violation
Performs Work-Around Violation
Ignored a CautionWarning
Failure to Prioritize Tasks Adequately
Wrong Choice of Action During an Operation
Inadequate Real‐Time Risk Assessment
Rushed or Delayed a Necessary Action
Breakdown in Visual Scan
Over-ControlledUnder-Controlled AircraftVehicleSystem
Unintended Operation of Equipment
Procedure Not Followed Correctly
Performance-Based Errors
Judgment and Decision Making Errors
Violations
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 106
Figure 2 Preconditions (Latent Failures or Conditions) (N=40)
14 (250)
24 (500)
48 (500)
11 (1000)
18 (125)
840 (200)
0 5 10 15 20 25 30 35 40
Seat and Restraint System Problems
Instrumentation amp Warning System Issues
Noise Interference
Environment
Physical Environment
Technological Environment
27 (286)
27 (286)
27 (286)
37 (129)
47 (511)
47 (571)
77 (1000)
24 (500)
44 (1000)
47 (571)
12 (500)
22 (1000)
27 (286)
740 (175)
0 5 10 15 20 25 30 35 40
Technical or Procedural Knowledge Not Retained After Training
InterferenceInterruption
Task OverUnder Saturation
Distraction
Negative Habit Transfer
Not Paying Attention
Complacency
Overconfidence
Physical IllnessInjury
Fatigue
Physical and Mental State
Physical Problem
State of Mind
Mental Awareness
211 (182)
311 (273)
311 (273)
411 (364)
811 (7227)
911 (818)
1140 (275)
0 5 10 15 20 25 30 35 40
Inadequate Task Delegation
TaskMission PlanningBriefingDebriefing Inadequate
Failure of CrewTeam Leadership
StandardProper Terminology Not Used
Critical Information Not Communicated
Failed to Effectively Communicate
Teamwork
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 107
Figure 3 Supervision (Direct Supervisory Chain of Command) (N=40)
Figure 4 Organization Influence (Upper-Level Management Command Level) (N=40)
114 (71)
114 (71)
214 (143)
314 (214)
1314 (929)
1440 (350)
511 (455)
511 (455)
711 (636)
1140 (275)
47 (571)
67 (857)
740 (175)
0 5 10 15 20 25 30 35 40
Selected Individual with Lack of Proficiency
Improper Role‐modeling
Failed to Provide Proper Training
Failed to IdentifyCorrect Risky or Unsafe Practices
SupervisoryCommand Oversight Inadequate
Performed Inadequate Risk Assessment ‐Formal
Selected Individual with Lack of Current or Limited Experience
Authorized Unnecessary Hazard
Allowing Unwritten Policies to Become Standard
Failure to Enforce Existing Rules
Supervisory Violations
Planned Inappropriate Operations
Inadequate Supervision
12 (500)
12 (500)
240 (50)
110 (100)
510 (500)
1040 (250)
11 (1000)
140 (25)
18 (125)
18 (125)
38 (35)
48 (500)
840 (200)
0 5 10 15 20 25 30 35 40
Organizational Over-confidence or Under-confidence in Equipment
Organizational Culture (attitude actions) Allows for Unsafe TaskMission
Purchasing or Providing Poorly Designed or Unsuitable Equipment
Organizational ProgramPolicy Risks not Adequately Assessed
Failure to Provide Adequate Manning Staffing Resources
Failure to remove inadequate worn-out equipment in timely manner
Inadequate infrastructure
Command and control resources are deficient
Failure to provide adequate operational information resources
Resource Problems
Personnel Selection amp Staffing
Policy and Process Issues
ClimateCulture Influences
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 108
Supplement Table 1- HFACS Content of Human Factor Analysis Classifi-
cation System [9] Tier main level sub-item nano code
Tier 1 Unsafe Acts
Perfor-
mance-Based
Errors
Unintended operation of equipment
Checklist not followed correctly
Procedure not followed correctly
Over-controlledunder-controlled aircraftvehiclesystem
Breakdown in visual scan
Rushed or delayed a necessary action
Judgment amp De-
cision-Making
Errors
Inadequate real‐time risk assessment
Failure to prioritize tasks adequately
Ignored a cautionwarning
Wrong choice of action during an operation
Violations
Performs work-around violation
Commits widespreadroutine violation
Extreme violation-lack of discipline
Tier 2 Preconditions
Environment
Physical environment
Environmental conditions affecting vision
Vibration effects vision or balance
Heatcold stress impairs performance
External force of object impeded an individualrsquos
movement
Lights of other vehiclevesselaircraft affected vision
Noise interference
Technological environment
Seat and restraint system problems
Instrumentation amp warning system issues
Visibility restrictions (not weather related)
Controls and switches are inadequate
Automated system creates unsafe situation
Workspace incompatible with operation
Personal equipment interference
Communication equipment inadequate
Physical and
Mental State
Physical problem
Substance effects (alcohol supplements medications
drugs)
Loss of consciousness (sudden or prolonged onset)
Physical illnessinjury
Fatigue
Inadequate adaptation to darkness
Dehydration
Body sizemovement limitations
Physical strength amp coordination (inappropriate for
task demands)
Nutritiondiet
State of mind
Psychological problem
Life stressors
Emotional state
Personality style
Overconfidence
Fu-Jen Journal of Medicine Vol 3 No 2 2020
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Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 109
Pressing
Complacency
Motivation
Motivational exhaustion (burnout)
Sensory misperception
Motion illusion-kinesthetic
Turning illusionbalance-vestibular
Visual illusion
Misperception of changing environment
Misinterpreted misread instrument
Misinterpretation of auditorysound cues
Spatial disorientation
Temporaltime distortion
Mental awareness
Not paying attention
Fixation
Task overunder saturation
Confusion
Negative habit transfer
Distraction
Geographically lost
Interferenceinterruption
Technical or procedural knowledge not retained after
training
Inaccurate expectation
Teamwork
Failure of crewteam leadership
Inadequate task delegation
Rankposition intimidation
Lack of assertiveness
Critical information not communicated
Standardproper terminology not used
Failed to effectively communicate
Taskmission planningbriefingdebriefing inadequate
Tier 3 Supervision
Supervisory Vio-
lations
Failure to enforce existing rules
Allowing unwritten policies to become standard
Directed individual to violate existing regulations
Authorized unqualified individuals for task
Planned Inappro-
priate Operations
Directed task beyond personnel capabilities
Inappropriate team composition
Selected individual with lack of current or limited experience
Performed inadequate risk assessment ‐formal
Authorized unnecessary hazard
Inadequate Su-
pervision
Supervisorycommand oversight inadequate
Improper role‐modeling
Failed to provide proper training
Failed to provide appropriate policyguidance
Personality conflict with supervisor
Lack of supervisory responses to critical information
Failed to identifycorrect risky or unsafe practices
Selected individual with lack of proficiency
Tier 4 Organizational
Influences
Resource Prob-
lems
Command and control resources are deficient
Inadequate infrastructure
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 110
Failure to remove inadequate worn-out equipment in timely
manner
Failure to provide adequate operational information resources
Fail to provide adequate funding
Personnel Selec-
tion amp Staffing
Personnel recruiting amp selection policies are inadequate
Failure to provide adequate manning staffing resources
Policy amp Process
Issues
Pace of ops-tempoworkload
Organizational programpolicy risks not adequately assessed
Provided inadequate procedural guidance or publications
Organizational (formal) training is inadequate or unavailable
Flawed doctrinephilosophy
Inadequate program management
Purchasing or providing poorly designed or unsuitable equip-
ment
ClimateCulture
Influences
Organizational culture (attitude actions) allows for unsafe
taskmission
Organizational over-confidence or under-confidence in equip-
ment
Unit missionaircraftvehicleequipment change or unit deacti-
vation
Organizational structure is unclear or inadequate
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 111
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
以 HFACS重新檢視根本原因分析案例挖掘造成醫療不良
事件之人為因素
鄭伃洵 1洪聖惠 12柯彤文 3王拔群 14
中文摘要
背景醫療不良事件(AMEs)的管理是促進病人安全的基石根本原因分析
(RCA)是探討重大病人安全不良事件問題但是由於無法解釋更廣泛的因素而受
到限制本研究使用人為因素分類與分析工具(HFACS)回溯審視醫療不良事件
以了解影響醫療不良事件的人為因素及各層面中錯誤原因之分佈或系統性問題
方法本研究回溯 2012-2016年間有做過根本原因分析之醫療不良事件以連續
性取樣方式(continuous sampling)收集 40例醫療不良事件以人為因素分類與分
析工具(HFACS)去系統性的挖掘每件案例發生錯誤之原因結果在行為層面中
分析結果主要為基礎技能錯誤(95)判斷和決策錯誤(875)其中在基礎技能
錯誤當中以未依程序作業執行(816)及未如預期設備操作(50)佔多數判斷和
決策錯誤中以現場風險評估不確實(686)及採取錯的步驟行為(686)佔多數
而在先決條件層面中以團隊合作(275)為主要因素包含溝通不良(818)及重
要訊息未以正確的方式即時傳達(727)佔多數在監督層面當中以監督不周
(929)或監督不妥當(929)為主要因素在組織政策和流程方面(50)以組織
系統的政策風險未充分評估(35)為主要因素結論本研究進一步了解醫療不
良事件在過去使用根本原因分析未探討到的人為因素反映出潛在的監督組織
行為或系統性的問題促進病人安全預防錯誤再發生
關鍵字病人安全醫療不良事件根本原因分析人為因素
1國泰醫療財團法人國泰綜合醫院 品質管理部
2國立臺灣大學健康政策與管理研究所
3振興醫療財團法人振興醫院 醫療品質管理中心
4輔仁大學醫學院
通訊作者王拔群 電子信箱 drtonyseednettw
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin 112
Submitted January 20 2020
Final version accepted April13
2020
Case Report
Juvenile Caruncular Atypical Lymphoid
Proliferation ndash A Rare Case Report
Cite as Hua-Wei Shih Yu-Chi Lin
Juvenile Caruncular Atypical
Lymphoid Proliferation ndash A Rare
Case Report Fu-Jen Journal of
Medicine 3(3) 112-119 2020
DOI
103966181020932020091803003
Hua-Wei Shih1 Yu-Chi Lin
1
1Department of Ophthalmology Shin Kong Wu Ho-Su Memorial Hos-
pital Taipei City Taiwan
Corresponding author E-mail address
yuchi067gmailcom (Yu-Chi Lin)
ABSTRACT
Lesions of the caruncle are very rare Most caruncular lesions are benign though there were still few reported malignant lesions Ocular adnexal lymphoproliferative disease (OALD) one of the differential diagnosis of caruncular lesion is seldom seen in young pa-tient In this article we report a 16-year-old boy with recurrent caruncular atypical lym-phoid proliferation We discuss the epidemiology clinical features images histomorpholo-gy and treatment between ocular adnexal lymphomas (OAL) and reactive lymphoid hyper-plasia (RLH)
Keywords caruncular lesion ocular adnexal lymphoproliferative disease ocular adnexal lymphoma
reactive lymphoid hyperplasia atypical lymphoid proliferation
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
113
INTRODUCTION Lesions of the caruncle are very rare Differen-
tial diagnosis includes nevus myeloproliferative
disorders tumors inflammation infection cysts
vascular lesions and fibrous Biopsy is essential
for diagnosis Levy J et al reported ocular ad-
nexal lymphoproliferative disease (OALD) was
relatively uncommon diagnosis among caruncu-
lar lesions [1]
OALD was seldom described in Asian popula-
tion especially for young age C-Y Cheng re-
ported age-standardized incidence of ocular
adnexal lymphomas (OAL) in Taiwan from 1979
to 1996 was below 07 per million per year and
mean age was 531 years old [2] In 2015 five
Taiwanese cases of OAL whose age ranging
from 45 to 64 were presented [3] However
there were few cases of conjunctival OAL or
RLH in Chinese pediatric patient
Here we present a case of 16-year-old boy with a
caruncular mass at his left eye with recurrence
one month after excision We describe his clini-
cal symptoms photographs pathological results
management and follow-up clinical course in
this report
CASE REPORT A 16-year-old healthy boy presented a mass
lesion at his left eye caruncle accompanied with
the symptom of tearing for one month (Figure 1)
He had no ocular pain no itchiness no blurred
vision no night sweating no fever and no body
weight loss The patient denied systemic diseas-
es and histories of surgery His bilateral best
corrected visual acuity (BCVA) were 66 and
intraocular pressure (IOP) were both within
normal range There were no remarkable find-
ings for his cornea lens fundus and physical
examination Excision was performed and the
mass was soft with fluid inside therefore con-
junctival pyogenic cyst was our initial diagnosis
However one month after the excision a pro-
truding mass recurred at the patientrsquos nasal can-
thus of left eye (Figure 2) There were some
differences compared to previous condition At
the first time the soft mass was contained in a
well-defined cyst wall which more favored py-
ogenic granulation However after short period
of recurrence solid consistency and unclear
margin were found which favored malignancy
Besides the mass partially involved beyond the
gray line of nasal part lower eyelid whereas last
time the cyst mainly extended from conjunctiva
of caruncle The second excisional biopsy was
performed Pathologic examination demonstrat-
ed abundant atypical lymphoid proliferation
(Figure 3A 3B) Immunohistochemical studies
showed that the lymphoid aggregation was
composed predominantly of CD20-positive cells
(Figure 3C) focal positive staining of CD3
(Figure 3D) CD5 CD23 CD10 and negative
staining of cyclin-D1 Unfortunately the cellular
morphology was difficult to be evaluated due to
marked crushing artifact Thus malignant lym-
phoma cannot be excluded totally
Orbital computed tomography (CT) showed a
lesion of soft tissue density at medial canthus of
left orbit without obvious nasolacrimal duct or
bony invasion (Figure 4A) Magnetic resonance
imaging (MRI) with contrast showed strong
enhancement at left medial canthus region (Fig-
ure 4B) There was no remarkable finding in the
systemic workup including complete blood
count and differential count biochemical pro-
files and 18F-fluoro-2-deoxyglucose positron
emission tomographycomputed tomography
(18F-FDG PETCT) indicating no evidence of
systemic involvement
After the second excision we preferred con-
servative management for him due to the uncer-
tainty of malignancy and to avoid side effects
from aggressive treatment No sign of recurrence
was noted after 10 months of observation The
follow-up photo was taken at three months after
the second operation (Figure 5)
DISCUSSION Ocular adnexal lymphoproliferative disease
(OALD) consists of the spectrum of lymphoid
disease affecting the tissues surrounding the eye
including ocular adnexal lymphomas (OAL) and
lymphoid hyperplasia (LH) [4] The conjunctiva
is an important location for extranodal lympho-
ma development which comprises 25 of OAL
[5]
OAL can be grouped into two categories based
on their appearance of cells under the micro-
scope low-grade and high-grade [6] Extranodal
marginal zone lymphoma of mucosa-associated
lymphoid tissue (EMZLMALT) is the most
common subtype of OAL followed by follicular
lymphoma [7-9] Both of the above are
low-grade lymphomas
LH can be further divided by histopathology into
reactive lymphoid hyperplasia (RLH) and atypi-
cal lymphoid hyperplasia (ALH) RLH has to-
tally benign morphology and immunophenotype
whereas ALH has borderline lesions between
RLH and lymphoma [10] OAL and LH are
mostly seen in patients with age between 50-70
years old There are rare cases in pediatric group
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
114
[71011] In the C-Y Chengrsquos statistical report of
OAL in Taiwan only 8 patients were younger
than 15 years old among the 101 cases of ocular
lymphoma [2] According to an US study inci-
dence rates of OAL were analyzed in different
age groups the group of age over 50 had the
highest incidence rate of 574 per million per-
son-years while the 0-19 age group had the
lowest incidence rate of 009 per million per-
son-years [12] The incidence of LH was even
less than OAL [13]
Patients with OALD may be asymptomatic or
with symptoms of proptosis eyelid swelling a
palpable painless mass or conjunctival salmon
patch Diplopia visual loss pain or inflamma-
tion occurred less frequently implying more
aggressive features [714]
Orbital LH is not distinguishable from low-grade
lymphoma radiologically They both typically
present a round or lobulated mass that diffusely
moderately enhances with contrast and usually
shows homogenous hypointense or isointense to
muscle barely invasion to bone or nervous sys-
tem [10] Atypical appearances including inho-
mogeneous calcification or bony changes may
be seen in high-grade lymphoma case reports
such as ocular adnexal diffuse large B-cell lym-
phoma (DLBCL) which is one of the more ag-
gressive type of OAL [7] Whole body PET is
used for not only the evaluation of systemic
involvement but also the standard for staging
lymphoma Our patientrsquos image studies revealed
neither obvious local invasion nor systemic ma-
lignancy indicating high-grade lymphoma was
less likely Low-grade lymphoma and benign
reactive lymphoid hyperplasia were still under
consideration
Histomorphology analysis and immunohisto-
chemistry (IHC) are essential for diagnosis
Flow cytometry and polymerase chain reaction
(PCR) technique are also applied to help differ-
entiate from RLH and OAL [1016] Our case
had immunohistochemical profile of positivity
for CD20 predominantly positivity focally for
CD3 CD5 CD10 CD23 and negativity for cy-
clin-D1 BCL-6 staining was not performed in
our casersquos biopsy Thus according to the IHC
report RLH ALH and follicular lymphoma are
probable diagnosis of our patient
Radiation therapy is the standard treatment for
low-grade OAL that is classified as T1N0M0 or
T2N0M0 according to the AJCC criteria [15]
İncesoy-Ouml zdemir S et al reported a 10-year-old
boy diagnosed of MALT lymphoma who was
treated with local radiotherapy (36 Gy) and
there were no local or systemic recurrences dur-
ing his nearly four-year follow-up [17] Another
case report represented a 21-year-old man of
conjunctival follicular lymphoma treated with
surgical excision only showing no evidence of
recurrence after 8 months follow-up [18] Other
treatment options for pediatric and juvenile OAL
were performed in some case reports including
intravenous rituximab intralesional interfer-
on-α-2b topical interferon a6 systemic doxycy-
cline surgical excision and postoperative local
cryotherapy [15]
Treatment for young conjunctival RLH was less
discussed in the past In a case series article
three children (9 13 14 years old respectively)
of RLH received surgical resection without fur-
ther postoperative management and no signs of
recurrence were noted during follow-up [19]
Short-term topical and oral corticosteroids after
surgical excision were prescribed in two pediat-
ric RLH patients for their small residual mass
However poor response in both cases was nota-
ble [20]
Our patient declined to receive radiotherapy or
any further postoperative treatment mainly due
to his concerning of possible side effects (such
as dry eye and cataract)
CONCLUSION We present a rare case of caruncle mass in this
report OALD is one of the relatively uncommon
diagnosis among caruncular lesions OALD
includes benign RLH and malignant OAL
which are both mainly seen in elderly patients
even rarer in pediatric or juvenile group
The standard treatment for low-grade OAL and
RLH in young patents are still debatable How-
ever long-term follow-up is suggested for both
OAL and RLH patients Though RLH has a be-
nign and self-limited course risk of malignant
transformation is possible
REFERENCES 1 Levy J Ilsar M Deckel Y et al Lesions of
the caruncle a description of 42 cases and
a review of the literature Eye
200923(5)1004-1018
2 C-Y Cheng and W-M Hsu Incidence of
eye cancer in Taiwan an 18-year review
Eye 200418152-158
3 Chui-Lien Tsen Muh-Chiou Lin
Youn-Shen Bee et al Ocular adnexal
lymphoma Five case reports and a
literature review Taiwan Journal of
Ophthalmology 20155(2)99-102
4 Liesegang TJ Ocular adnexal
lymphoproliferative lesions Mayo Clin
Proc 199368(10)1003-1010
5 Kirkegaard MM Coupland SE Prause JU
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
115
et al Malignant lymphoma of the
conjunctiva Surv Ophthalmol
201560(5)444-458
6 Stacy RC Jakobiec FA Schoenfield L et
al Unifocal and multifocal reactive
lymphoid hyperplasia vs follicular
lymphoma of the ocular adnexa Am J
Ophthalmol 2010150(3)412-426
7 Sullivan TJ Ocular Adnexal
Lymphoproliferative Disease In Guthoff
RF Katowitz JA eds Oculoplastics and
Orbit Berlin Heidelberg Springer
20101-19
8 White Valerie A Understanding and
Classification of Ocular Lymphomas
Ocular Oncology and Pathology
20195379-386
9 Stefanovic A Lossos IS Extranodal
marginal zone lymphoma of the ocular
adnexa Blood 2009114(3)501-510
10 Andrew NH Coupland SE Pirbhai A et al
Lymphoid hyperplasia of the orbit and
ocular adnexa A clinical pathologic review
Surv Ophthalmol 201661(6)778-790
11 Ferry JA1 Fung CY Zukerberg L et al
Lymphoma of the ocular adnexa A study
of 353 cases Am J Surg Pathol
200731(2)170-184
12 WM Hassan MS Bakry HM Hassan et al
Incidence of orbital conjunctival and
lacrimal gland malignant tumors in USA
from Surveillance Epidemiology and End
Results 1973-2009 Int J Ophthalmol
20169(12)1808-1813
13 Ajay A Rao John H Naheedy James Y-Y
Chen et al A Clinical Update and
Radiologic Review of Pediatric Orbital
and Ocular Tumors Journal of Oncology
2013(9)975908
14 Sullivan TJ Whitehead K Williamson R
et al Lymphoproliferative disease of the
ocular adnexa a clinical and pathologic
study with statistical analysis of 69
patients Ophthal Plast Reconstr Surg
200521177-188
15 Tanenbaum RE Galor A Dubovy SR et al
Classification diagnosis and management
of conjunctival lymphoma Eye Vis (Lond)
2019622
16 Olga Klavdianou Georgios Kondylis
Vasileios Georgopoulos et al Bilateral
benign reactive lymphoid hyperplasia of
the conjunctiva a case treated with oral
doxycycline and review of the literature
Eye Vis (Lond) 2019626
17 İncesoy-Ouml zdemir S Yuumlksek N Bozkurt C
et al A rare type of cancer in children
extranodal marginal zone B-cell (MALT)
lymphoma of the ocular adnexa Turk J
Pediatr 201456(3)295-298
18 Lynn J Poole Perry Frederick A Jakobiec
Peter A D Rubin Conjunctival Pediatric
Follicular Lymphoma Arch Ophthalmol
2012130(7)941-943
19 Abdullah Al-Mujaini Upender Wali
Anuradha Ganesh1 et al Ocular Adnexal
Reactive Lymphoid Hyperplasia in
Children Middle East Afr J Ophthalmol
201219(4)406-409
20 McLeod SD Edward DP Benign
lymphoid hyperplasia of the conjunctiva in
children Arch Ophthalmol
1999117(6)832-835
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
116
FIGURES
Figure 1 Slit lamp image of a mass lesion at the patientrsquos left eye caruncle for one month
Figure 2 One month after the first excision a protruding mass recurred at the patientrsquos nasal canthus
of left eye It partially involved beyond the gray line of nasal part lower eyelid
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
117
Figure 3 Histomorphology analysis and immunohistochemistry study of the caruncular lesion Abun-
dant atypical lymphoid proliferation presented in low-power photomicrograph (A) and
high-power photomicrograph (B) under hematoxylin-eosin staining The lymphoid aggrega-
tion was composed predominantly of CD20-positive cells (C) and focal positive staining of
CD3 (D)
Figure 4 Non-contrast orbital computed tomography showed a lesion of soft tissue density at medial
canthus of left orbit without obvious nasolacrimal duct or bony invasion (A) Magnetic reso-
nance imaging with contrast showed strong enhancement at left medial canthus region (B)
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
118
Figure 5 The follow-up photo were taken at three months after the second excision showing no signs
of recurrence
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
119
Juvenile Caruncular Atypical Lymphoid Proliferation ndash A Rare Case Report
罕見病例報告mdash青少年之淚阜非典型淋巴增生
施驊瑋 1林友祺 1
中文摘要
淚阜病灶相當罕見大部分為良性病灶眼睛及附屬結構淋巴增生疾病為其
鑑別診斷之一非常少見於年輕人或兒童我們報告一位 16歲的健康男性因
左眼淚阜無痛性腫塊接受切除手術卻於術後一個月復發執行第二次切除手術
後門診追蹤十個月未再復發此案例表現了部分良性與部分惡性腫瘤的特徵
我們針對反應性淋巴增生眼睛及附屬結構淋巴癌兩個疾病做討論及文獻回顧
關鍵字淚阜病灶眼睛及附屬結構淋巴增生疾病眼睛及附屬結構淋巴癌反
應性淋巴增生非典型淋巴增生
1 新光吳火獅紀念醫院眼科
通訊作者林友祺 電子信箱 yuchi067gmailcom
Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh 120
Submitted March 26 2020
Final version accepted April 16
2020
Case Report
Hyperacute intramembranous hemor-
rhage after burr hole craniostomy for
chronic subdural hematoma
Cite as Meng-Chi Lin Jui-Ming
Sun Yu-Hao Chen Cheng-Ta
Hsieh
Hyperacute intramembranous
hemorrhage after burr hole crani-
ostomy for chronic subdural he-
matoma Fu-Jen Journal of Medi-
cine 3(4) 120-125 2020
DOI
103966181020932020091803004
Meng-Chi Lin1 Jui-Ming Sun23 Yu-Hao Chen24 Cheng-Ta
Hsieh567
1Department of Surgery Zuoying Branch Kaohsiung Armed Forces
General Hospital Kaohsiung 813 Taiwan 2Section of Neurosurgery Department of Surgery Chia-Yi Christian
Hospital Chia-Yi City 600 Taiwan 3Department of Biotechnology Asia University Taichung City 41354
Taiwan 4Chung-Jen Junior College of Nursing Health Sciences and Manage-
ment Chia-Yi Country 62241 Taiwan 5Division of Neurosurgery Department of Surgery Sijhih Cathay Gen-
eral Hospital New Taipei City 22174 Taiwan 6Department of Medicine School of Medicine Fu Jen Catholic Univer-
sity New Taipei City 24205 Taiwan 7Department of Neurological Surgery Tri-Service General Hospital
National Defense Medical Center Taipei 114 Taiwan
Corresponding author E-mail address
nogormail2000comtw (Cheng-Ta Hsieh)
ABSTRACT
Burr hole craniostomy with closed-system drainage is an effective and common neurosurgical procedure to manage chronic subdural hematoma Postoperative hem-orrhage a well-known but infrequent complication may result in increased neurolog-ical deficits However hyperacute intramembranous hemorrhage within the inner and outer membrane of hematoma after burr hole craniostomy with irrigation and closed-system drainage has not been described previously Herein we report a case of postoperative spontaneous hyperacute intramembranous hemorrhage after burr hole craniostomy with closed-system drainage to manage a chronic subdural hematoma we subsequently discuss the possible pathophysiological mechanisms and review the relevant literature
Keywords Chronic subdural hematoma acute subdural hematoma bleeding burr hole craniostomy
drainage
Fu-J
Meng
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TRODUConic subdural t common contervention [1
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of Medicine V
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(Figure 2B)membranecto
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Vol 3 No 4 2
Acute intram
Yu-Hao Chen
CSDH) one ofuiring neurosugressive collechematomas in
outer and ievidence suggwith or wite and widely ut and that it ] Recurrence r this surgerywever the hyng after burr ely been discucase of a pa
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previous CS
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ISCUSSIO61-year-old won without regd been takingning Ganodermrs She was tment when shurological exasgow Coma S
muscle strengs was 45 on
ale Her laborh the normal rnoted Brain
n revealed Ch a marked m
ently she receniostomy withinage ring surgery mthe subdural sn of the duramatoma The arile saline throsed drainage swever this inm the subduraealed a hyperdural space fniostomy siteniotomy withthe hematom
morrhage was d inner membgure 3) No aface was obseealed an organn of fibroblasne Postoperaogical deficits
EFERENCRohde VComplicatiand closedsubdural analysis of
active bleedinerved Histolonized hematots and capilla
ative recoverywas gradual a
ON oman had a hi
gular medicatig nutritional ma lucidum referred to ohe became proxamination rScale ratings wgth score in th
the Medical ratory examinranges with nn computed
CSDH in the midline shift (ived one righth irrigation a
motor oilndashlikespace was uncal and outer marea was irrigaough the subdusystem was plcreased the rel space An emracute hemorrfrom the frone (Figure 2B
membranectma was perfo
only observebrane of theactive bleedinerved Histolonized hematots and capilla
ative recoverywas gradual a
CES V Graf Gons of burr-
d-system draihematomas
f 376 patient
ng from the ogical examinoma with prolaries in the m
y of previous and favorable
history of hypeion treatmentsupplements for more tha
our emergencyogressively drrevealed thatwere E1M5V2he left side ex
Research Conation results no bleeding ditomography right hemisp
(Figure 1) St parietal burrand closed-sy
e fluid accumucovered after membranes oated with 50 m
dural catheter laced (Figureedness of the mergency brairrhage in the ntal region to
B) An emergtomy and remormed The ed within the e previous Cng from the ogical examinoma with prolaries in the m
y of previous and favorable
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of Medicine V
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iew of CT rev
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Vol 3 No 4 2
Acute intram
Yu-Hao Chen
vealing a layer
displaying a m
quent CT scan
em drainage (
rhage in the ri
2020
membranous
Cheng-Ta Hs
red type of CS
midline shift
ns (A) Bone w
(white arrow)
ight frontal re
hemorrhage
ieh
SDH (white ar
window view
and (B) Soft
gion (white ar
rrow) in the rig
showed the b
tissue windo
rrow)
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burr hole crani
ow showed hy
123
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Fu-J
Meng
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Jen Journal o
g-Chi Lin Ju
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brane
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of Medicine V
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(white arrow)
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Vol 3 No 4 2
Acute intram
Yu-Hao Chen
o revealing ac
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2020
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cute intramem
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124
mem-
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Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh
125
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
慢性硬腦膜下出血進行鑽顱引流手術造成超急性夾膜內出
血
林孟楫 1孫瑞明 23陳昱豪 24謝政達 567
中文摘要
鑽顱併封閉系統引流手術是治療慢性硬腦膜下出血患者一種有效且常見的
神經外科手術方式術後出血可能導致神經功能缺損惡化是眾所周知但不常見
的併發症之一然而至今仍未有鑽孔併封閉系統引流造成原本慢性硬腦膜血
塊內膜和外膜間急性夾膜間出血案例在這裡我們報告一例慢性硬腦膜下出
血病患者接受鑽顱併封閉系統引流手術治療造成術後急性夾膜間出血我們在
本文中討論可能的致病機制並回顧相關文獻
關鍵字慢性硬腦膜下出血急性硬腦膜下出血出血鑽顱術引流
1國軍高雄總醫院左營分院 外科部
2崇仁醫護管理專科學校
3亞洲大學 生物科技學系
4戴德森醫療財團法人嘉義基督教醫院 外科部 神經外科
5汐止國泰綜合醫院 神經外科
6輔仁大學 醫學系
7 國防醫學院 三軍總醫院 神經外科
通訊作者謝政達 電子信箱 nogormail2000comtw
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
126
Submitted January 21 2020
Final version accepted July 08
2020
Case Report
Hamartoma of the breast A case report
Cite as Hsuan-An Chen
Cheng-Yu Lo Shih-Hung Huang
Chin-Lung Lin
Hamartoma of the breast A case
report Fu-Jen Journal of Medicine
3(5) 126-130 2020
DOI
103966181020932020091803005
Hsuan-An Chen1 Cheng-Yu Lo
3 Shih-Hung Huang
3 Chin-Lung
Lin2
1Department of Surgery Cathay General Hospital Taipei Taiwan
2Department of General Surgery Cathay General Hospital Taipei Tai-
wan
3Department of Pathology Cathay General Hospital Taipei Taiwan
Corresponding author E-mail address
lungyungmailcom (Chin-Lung Lin)
ABSTRACT
Breast hamartoma is an uncommon benign tumor rarely associated with malignancy An
excision and histological examination is necessary for the differential diagnosis We report
a case of a 49-year-old female patient presenting with a lump in the right breast Ultrasound
examination which demonstrated a 4411 cm hypoechoic lesion with lipoma Partial mas-
tectomy was arranged and the diagnosis of a hamartoma was confirmed by the histological
examination
Keywords Breast tumor Hamartoma Ultrasound
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
127
INTRODUCTION The hamartoma is a benign tumor-like lesion
that can affect various organs of the body in-
cluding lungs kidneys skin and more rarely the
breast In 1981 the hamartomas were recognized
in the WHO classification[1] They are defined
as well-demarcated mass of mammary ducts and
lobules containing varying amounts of fibrous
and adipose tissue and producing a distinctive
mammographic image
CASE REPORT A 49 year-old female had past history of left
breast mastitis with abscess status post partial
mastectomy This time she presented to our out
patient clinic for breast examination Physical
examination revealed a painless palpable mova-
ble and painless lump at upper outer quadrant of
right breast The risk of breast cancer was not
noted and the patient did not have any family
history of breast cancer The patient also denied
any trauma history before Ultrasound examina-
tion was arranged which demonstrated a 4411
cm hypoechoic lesion with lipoma at 3 oclock 2
cm from nipple of right breast and multiple hy-
poechoic nodules of various size in both breasts
and there was no suspicious axillary lymph
nodes noted (Figure1) Surgical treatment was
arranged partial mastectomy of right breast
harmartoma was successfully performed A 32 x
31 x 21 cm tumor was completely excised
Grossly examination showed a gray to yellow
and firm to fatty The diagnosis of a hamartoma
was confirmed by the histological examination
Microscopically sections of the breast lesion
show mammary hamartoma composed of ducts
lobules with interlobular fibrous tissue and adi-
pose tissue Fibrocystic change apocrine meta-
plastic ducts and scattered foci of adenosis are
noted The overall lobulocentric architecture and
the 2-cell pattern of the epithelium are preserved
columnar cell change and focal microcalcifica-
tion are present (Figure2) Based on submitted
biopsy specimen in-situ or invasive tumor cells
are not identified
DISCUSSION Hamartoma of the breast is a benign tumor like
nodule it was also known as fibroadenolipoma
lipofibroadenoma or adenolipoma based on its
predominant components It was composed of
varying amounts of glandular adipose and fi-
brous tissue[2] Hamartomas were first described
in 1971 by Arrigoni et al in a study of 10 patients
which breast tumors clinically and grossly re-
sembled fibroadenomas[3]
A higher predominance of tumors exists in fe-
males compared with males Hamartomas are
slowly-growing lesions with the diameter rang-
ing from 2 cm to 5 cm sometimes hamartomas
can reach giant diameter [4]
The clinical diagnosis of hamartoma is based on
the findings from mammography sonography
and histology examinations The hamartomas are
usually incidentally diagnosed by the women
older than 40 year-old starting mammography
screening
On physicial examination harmatomas are usu-
ally occult painless they may be as large mo-
bile soft to firm masses[5] Ultrasound showed
well capsulated mass with echogenic rim and
internal heterogeneity Mammography exam
showed well-circumscribed round to oval
masses containing fat and soft tissue densities
with a thin radiopaque pseudocapsule The
pseudocapsule results from displacement of
breast parenchyma by the tumor [56] In Pa-
thology finding microglandular adenosis is pre-
sent in fibroadipose stroma surrounded by a thin
fibrous capsule It composed of a combination of
epithelial and stromal elements usually with
normal ducts or lobules although variations of
normal tissue may also be seen Fibroadenoli-
poma myoid hamartoma and chondrolipoma are
histological variations of hamartomas depend-
ing on the proportion of normal breast tissue
elements[7]
Malignancy associated with hamartomas are
very rare[8] However it has been reported
hamartomas develop into carcinoma Malignant
transformation can occur as a result of cellular
atypia in the epithelial component of the mass[9]
Surgical removal is the curative method for
breast hamartomas[10] Diagnostic material such
as mammography ultrasonography or core nee-
dle biopsy may not give the definitive diagnosis
Therefore surgical excision and histological
examination is necessary for differential diagno-
sis[111213]
Although it is rare hamartoma can be seen along
with malignancy as it is formed from similar
components of breast tissue Therefore careful
diagnosis and appropriate management including
surgery are required
REFERENCES 1 World Health Organization (1981)
Histological typing of breast tumors In
International histological classification of
tumors 1981 2nd ed
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
128
2 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11435ndash449
2006
3 ArrigoniMG DockertyMB JuddES
The identificationand treatment of
mammary hamartoma Surg Gynecol
Obstet1971 133 577-82
4 Sanal HT Ersoz N Altinel O Unal E Can
C Giant hamartoma of the breast Breast J
2006 12 84-85
5 Feder JM de Paredes ES Hogge JP
Wilken JJ Unusual breast lesions
radiologic-pathologic correlation
Radiographics 1999 19S11ndashS26
6 Murat A Ozdemir H Yildirim H Poyraz
AK Ozercan R Hamartoma of the breast
Australas Radiol 200751 Spec NoB37ndash
9
7 Fisher CJ Hanby AM Robinson L Millis
RR Mammary hamartoma-a review of 35
cases Histopathology 1992 20 99-106
8 Choi N Ko ES Invasive ductal carcinoma
in a mammary hamartoma case report and
review of the literature Korean J Radiol
2010 Nov-Dec11(6)687-91
9 Lee EH Wylie EJ Bourke AG Bastiaan
De Boer W Invasive ductal carcinoma
arising in a breast hamartoma two case
reports and a review of the literature Clin
Radiol 2003 58 80-3
10 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11 435 ‑449
2006
11 Coyne J Hobbs FM Boggis C Harland R
Lobular carcinoma in a mammary
hamartoma J Clin Pathol 199245936ndash
937
12 G M K Tse B K B Law T K F Ma A B W
Chan Hamartoma of the breast a
clinicopathological review J Clin Pathol
200255951ndash954
13 RAAmir SSheikh BreasthamartomaA
report of 14cases of an under-recognized
and under-reported entity International
Journal of Surgery Case Reports
22(2016)1ndash4
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
129
FIGURES
Figure 1 Ultrasound shows a 4411 cm hypoechoic lesion with lipoma at 3 oclock 2 cm from nipple
of right breast
Figure 2 Photomicrograph shows mammary hamartoma composed of ducts lobules with interlobular
fibrous tissue and adipose tissue
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
130
Hamartoma of the breast A case report
乳房錯構瘤罕見個案報告
陳宣安 1羅承裕 3黃世鴻 3林錦龍 2
中文摘要
乳房錯構瘤是一種罕見之乳房良性腫瘤切除手術及病理化驗來做鑑別診斷
我們報告一位 49歲女性以可觸摸到無痛性右側乳房腫塊為臨床表徵超音波
看到一個邊緣清楚低迴音的腫塊病患接受手術切除病灶病理診斷證實為乳
房錯構瘤
關鍵字乳房腫瘤錯構瘤超音波攝影
1國泰綜合醫院外科部
2國泰綜合醫院一般外科
3國泰綜合醫院病理科
通訊作者林錦龍 電子信箱 lungyungmailcom
Fu-Jen Journal of Medicine
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Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang
99
Submitted October 11 2019
Final version accepted February
02 2020
Original Research Article
Human Factors Underlying Adverse
Medical Events Revisit Root Cause Anal-
ysis Cases Using the HFACS
Cite as Yu-Hsun Cheng
Sheng-Hui Hung Tung-Wen Ko
Pa-Chun Wang
Human Factors Underlying Ad-
verse Medical Events Revisit
Root Cause Analysis Cases Using
the HFACS Fu-Jen Journal of
Medicine 3(2) 99-111 2020
DOI
103966181020932020091803002
Yu-Hsun Cheng1 Sheng-Hui Hung
12 Tung-Wen Ko
3 Pa-Chun
Wang14
1Department of Quality Management Cathay General Hospital Taipei
Taiwan
2Institute of Health Policy and Management National Taiwan Universi-
ty Taipei Taiwan
3Center for Healthcare Quality Management Cheng Hsin General Hos-
pital Taipei Taiwan
4Fu Jen Catholic University School of Medicine New Taipei City Tai-
wan
Corresponding author E-mail address
drtonyseednettw (Pa-Chun Wang)
ABSTRACT Background Appropriate management of adverse medical events (AMEs) is the corner-
stone of patient safety Root cause analysis (RCA) is used to investigate serious or
high-frequency errors but is limited by its inability to explain a broader scope of factors
We re-reviewed RCA cases to understand the underlying human organizational or system-
ic factors affecting AMEs Methods A total of 40 consecutive RCA cases (2012-2016) were
retrieved from the AMEs database A panel was organized to retrospectively re-review these
cases using the Human Factor Analysis and Classification System HFACS Results For
active failures errors stemmed largely from performance-based (95) judgment and deci-
sion-making errors (875) Incorrectly followed procedures (816) and accidental
equipment operation (50) were the most common types of performance-based errors In-
adequate real-time assessment (686) and inappropriate operative actions (686) were
the most common decision-making errors For sources of latent failure teamwork problems
(275) including failure to effectively communicate (818) and communicate critical
information (727) were common Inadequate supervision (929) or command over-
sights (929) were the most common problems related to inadequate supervision (35)
Organizational programpolicy risks not adequately assessed (50) were the most common
problems related to policy and process problem (25) Conclusions The HFACS review
enhances our understanding of human factors underlying AMEs The HFACS reveals latent
supervisory organizational or systematic problems that cannot be addressed through tradi-
tional RCA Keywords patient safety adverse events root cause analysis human factors
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 100
INTRODUCTION Patient safety involves the reduction of patient
harm from potentially avoidable unintended
outcomes [1] Studies have revealed that 50ndash
80 of adverse medical events (AMEs) are pre-
ventable [2-4] to eliminate such errors the ap-
propriate management of AMEs hence repre-
sents the cornerstone of patient safety work
Through incident reporting investigation and
analysis healthcare providers can correct or
re-engineer their care processes to prevent inci-
dent recurrence [25] One of the most popular
tools for investigating AMEs is root cause anal-
ysis (RCA) RCA reconstructs a chain of errors
to identify the deviation of care from normal
processes Nonetheless with a lack of standard-
ized nomenclature and investigation procedures
RCA report conclusions are sometimes too sub-
jective and nonspecific to facilitate any actiona-
ble safety improvement plans [5-7] According
to the UK Health and Safety Executive defini-
tion human factors are environmental organiza-
tional occupational or individual human char-
acteristics which influence behavior at work
such that health and safety are affected [8] Hu-
mans and systems are prone to errors and stud-
ies have showed that nearly 70 of medical
errors involve human factors [2-4] Reasonrsquos
Swiss cheese model described the penetration of
causative human errors through layers of defen-
sive barriers leading to system collapse [9]
With much focus on the temporal sequence and
severity of departure from accepted practices in
an incident the effectiveness of RCA is often
challenged by its incapability of exploring un-
derlying human organization or even systemic
factors [5-7] Reason and others have proposed
that errors can occur at 4 levels 1) unsafe acts
(operator actions) 2) preconditions for unsafe
acts (environmental factors contributing to er-
rors) 3) inadequate supervision (management
actions affecting the operator) and 4) organiza-
tional influences (organizational culture policies
and procedures that affect the operator) [9]
Based on this theory Wiegmann and Shappell
developed the Human Factor Analysis Classifi-
cation System (HFACS) to describe human fac-
tors causing accidents from 4 tiers of categories
Each of these categories consists of nanocodes to
represent specific human behavior or system
problems leading to errors [9-10] The tier for
unsafe acts involves actual provider actions (er-
rors or rule violations) directly leading to events
The tier representing preconditions for unsafe
acts includes operational personnel and envi-
ronmental factors The supervision tier addresses
leadership problems operational planning fail-
ure or correction and supervisory ethics The
tier for organizational influences deals with re-
source management organizational climate and
operational processes (Supplement Table 1) The
HFACS provides standardized investigation
processes for the systematic analysis of common
causes of adverse events across national defense
nuclear power navy aviation and healthcare
industries Taiwan launched its nationwide
AME-reporting system the Taiwan Patient
Safety Reporting System (TPR) in 2004 RCA
methodology was subsequently introduced to the
healthcare industry by the Joint Commission of
Taiwan [11] Since 2012 appropriate manage-
ment of AMEs has been listed as a national pa-
tient safety goal [12] RCA is required by the
Ministry of Health and Welfare for major AMEs
Aside from RCA a comprehensive structural
reliable and valid framework is urgently re-
quired to further guide organizational or even
national patient safety policies In this study we
used the HFACS to review our RCA cases aim-
ing to investigate human factors underlying se-
vere or frequent AMEs
MATERIALS AND METHODS Through continuous sampling 40 consecutive
RCA cases (2012-2016) were retrieved from a
hospitalrsquos (Cathay General Hospital Taipei
Taiwan) AME-reporting system database The
database contains AMEs relating to areas such as
medication patient falls surgery transfusion
clinical care public accidents security hospital
violence tube-related complication unplanned
cardiopulmonary resuscitation laboratory testing
and examination and anesthesia The RCA cases
were sentinel or high-frequency events classified
according to severity assessment category (SAC)
[1113] The SAC is an evaluation method for
categorizing AMEs by severity of effect on pa-
tients health and risk of incident reoccurrence
The HFACS has been modified (from the US
Department of Defense version 70) and trans-
lated into Mandarin Chinese with authorization
from the original developers [10] The Chi-
nese-version HFACS for Taiwan is a valid in-
strument (content validity index 09 Cronbachrsquos
α gt07 interrater reliability Κ 04-10) equiva-
lent to the original English version [9] The
HFACS contains 4 tiers 13 subitems and 109
nanocodes (Supplement Table 1) A panel of 6
reviewers was established All reviewers were
from clinical or management (quality and patient
safety management) backgrounds Reviewers all
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 101
finished human factor education and were
trained to use the HFACS through a consensus
meeting Each RCA case was randomly assigned
to 2 reviewers Human factors leading to partic-
ular AMEs were identified and confirmed when
2 reviewers reached agreement The distribution
of errors among tiers subitems and nanocodes
are provided with descriptive statistics () The
study was approved by the Institutional Review
Board of Cathay General Hospital
(CGH-P105095)
RESULTS AMEs related to laboratory testing and examina-
tion (n = 16) clinical care (n = 9) and medica-
tion (n = 7) were the most commonly observed
in the RCA Most AMEs in this cohort are
ranked as being SAC level 3 (n = 15) or 4 (n =
17) (Table 1)
Acts (Active Failures)
This tier of errors contains 3 subitems and 13
nanocodes In the 40 RCA cases perfor-
mance-based errors for 38 (95) and judgment
and decision-making errors for 35 (875) com-
prised the most common error types with viola-
tion for 6 (15) less common Procedure fol-
lowed incorrectly for 31 out of 38 (816) was
the most common performance-based problem
Inadequate real-time risk management for 24 out
of 35 (686) was the most common judgment
or decision error All of the rule violations were
workaround types for 6 out of 6 (100) (Figure
1)
Preconditions(Latent Failures)
This tier of errors has 9 subitems and 58 nano-
codes In the 40 RCA cases teamwork for 11
(275) and environmental for 8 (20) factors
contributed to most of the errors with mental
and physical state the next most common factor
for 7 (175) Communication for 9 out of 11
(818) and information relay for 8 out of 11
(727) were the most common issues related to
teamwork Few contributors mentioned failures
related to technical errors for 4 (50) or physi-
cal for 1 (125) environment Not paying at-
tention for 4 out of 7 (571) and negative habit
transfer for 4 out of 7 (571) were common
mental contributes noted for 7 (100) Overcon-
fidence was the most common problem related
to emotional status for 4 out of 7 (571) Fa-
tigue was observed in only 2 cases for 2 out of 2
physical problems (100) (Figure 2)
Supervision(Direct Supervisory Chain of
Command)
This tier of errors contains 3 subitems and 17
nanocodes In the 40 RCA cases inadequate
supervision for 14 (35) and inappropriately
planned operations for 11 (275) factors con-
tributed to most of the respective errors fol-
lowed by supervisory violations for 7 (175)
Supervisory or command oversights for 13 out
of 14 (929) were the most common sources of
supervision inadequacy Authorized unnecessary
hazards for 7 out of 11 (636) were the most
common inappropriately planned operations
Failure to enforce rules for 6 out of 7 (857)
was the most common supervisory violation
(Figure 3)
Organization Influence (Upper-Level Man-
agement)
This tier of errors contains 4 subitems and 18
nanocodes In the 40 RCA cases policy and
process issues for 10 (25) and resources prob-
lem for 8 (20) were major concerns Few of
the respective problems are related to climate
and cultural influences for 2 (5) or to person-
nel selection and staffing for 1 (25) Poorly
assessed organizational programs or policy risks
for 5 out of 10 (50) were the most common
policy and process problems Failure to provide
adequate operational information resources for 4
out of 8 (50) and command and control re-
source deficiency for 3 out of 8 (375) were
the main resource management problems Little
was revealed regarding organizational climate
and culture (n = 1 out of 2 50) or staffing for 1
out of 1 (100) (Figure 4)
DISCUSSION Health care is a complex system comprising
many high-reliability organizations (HROs) The
vulnerability of HROs stems from the participa-
tion of multidisciplinary teams in the processes
along a variety of patient care timelines How-
ever humans and systems are inherently prone
to errors the appropriate management of AMEs
is acknowledged to be the cornerstone of patient
safety AMEs should be reported investigated
analyzed and handled appropriately[14] Theo-
retically by analyzing the pattern of key defects
providers can fix errors and re-engineer their
care processes to reduce the possibility of AME
recurrence Taiwan established its nationwide
TPR in 2004 so far 7000 health care facilities
have participated and the database has accumu-
lated more than 055 million AMEs[11] Infor-
mation generated from the TPR database can
improve patient safety at individual organiza-
tional or even national levels However despite
relentless efforts few substantial improvements
have been achieved in patient safety [15-17]
Since its introduction in Taiwan in 2006 the use
of RCA for AMEs has encountered some diffi-
culties 1) No structural and standardized
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 102
framework exists for investigation
cross-institution variability and interrater relia-
bility are often ignored 2) Conclusions are often
subjective and corrective recommendations are
less actionable relying on individual reviewersrsquo
professional backgrounds and their experiences
3) Much focus on event reconstruction and oper-
ator performance means that factors relating to
human behavior organizational culture and
system weakness are not comprehensively ad-
dressed [671718] Traditionally attempts to
improve patient safety in the health care industry
are largely reactive in nature identifying and
correcting errors in care processes [1920]
Causes of defects are not thoroughly understood
Proactive approaches must be taken to address
systematic problems within a complex system
[720] Research suggests that human error is a
causal factor in the occurrence of AMEs AME
investigation targets have moved from skill defi-
ciency toward decision-making attitudes super-
visory factors and even organizational climate
or culture HFACS methodology is based on the
Swiss cheese model that also emphasizes active
and latent failures [921] The study provides
some noteworthy findings First most AMEs as
expected involve active failures such as failure
to follow procedure accidental operation of
equipment inadequate real-time risk manage-
ment and inappropriate action These are all
sharp ends in classic RCA environment physi-
cal and mental factors are less prevalent This
proves that retrospectively determining addi-
tional causal factors is difficult when infor-
mation has not been collected during preliminary
investigation (Figure 1) Second team-
work-related problems particularly in relation to
communication and information relay are well
addressed This may be attributed to the dec-
ade-long institution-wide routine crew resource
management training in the respective research
hospital (Figure 2) Third the HFACS success-
fully reflects the importance of supervisory roles
in the occurrence of AMEs and this cannot be
overlooked (Figure 3) Fourth latent failures
especially in organizational climate or cultural
dimensions have been less frequently addressed
in incident reports a limitation of traditional
RCA However the HFACS review suggests
room for improvement in resource allocation and
policy modification within the hospital The
results of studies can make the organization
think about how to improve the patient safety
and management process from the perspective of
human factors such as improving the comfort of
the working environment and replacing and
equipment resources to prevent personnel from
affecting the medical quality and patient safety
due to the environment or equipment Need to
appropriate assessment of applicability and ade-
quate training of manpower is required The
management and control of risks should be fully
evaluate and grasp resource management and
leaders need to participate in and promote medi-
cal quality and patient safety activities to en-
hance its culture (Figure 4) No panacea exists
to ensure patient safety and improvement targets
originate largely from event investigation find-
ings Unfortunately factors identified from
AMEs are often self-explanatory with little value
for further action correction Reinforcement of
policy or processes redundant education or
repetitious training are formulaic overprescribed
RCA recommendations The use of HFACS in
this study proves that a structural prospective
AME investigation format can potentially help
with proactive patient safety management We
suggest developing an interview guideline for
the routine use of HFACS as a complement to
RCA in every AME investigation This study is a
retrospective study The underlying human fac-
tors can be under-estimated owing to the lack of
related information in the original RCA reports
CONCLUSION The HFACS review in this study enhances our
understanding of human factors in AMEs that
had previously been insufficiently scrutinized
Aside from active process and communication
errors the HFACS enables the prospective in-
vestigation of latent supervisory organizational
or systematic problems that cannot be addressed
through traditional RCA
REFERENCES 1 T Brennan L Leape N Laird et al
Incidence of adverse events and
negligence in hospitalized patients results
of the Harvard Medical Practice Study I N
Engl J Med 1991324370-376
2 Wang CH Shih CL Chen WJ et al
Epidemiology of medical adverse events
perspectives from a single institute in
Taiwan J Formos Med Assoc
2016115434-439
3 Vincent C Simon R Sutcliffe K et al
Errors Conference Executive Summary
Acad Emerg Med 200071180-1182
4 Taitz J Genn K Brooks V et al
System-wide learning from root cause
analysis A report from the New South
Wales Root Cause Analysis Review
Committee Qual Saf Health Care
2010191-5
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 103
5 Hutchinson A Young TA Cooper KL et
al Trends in healthcare incident reporting
and relationship to safety and quality data
in acute hospitals results from the
National Reporting and Learning System
Qual Saf Health Care 2009185-10
6 Mitchell RJ Williamson AM Molesworth
B et al A review of the use of human
factors classification frameworks that
identify causal factors for adverse events
in the hospital setting Ergonomics
2014571443-1472
7 Gurses AP Ozok AA Pronovost PJ Time
to accelerate integration of human factors
and ergonomics in patient safety BMJ
Qual Saf 201221347-351
8 Health and Safety Executive Introduction
to human factors
httpwwwhsegovukhumanfactorsintro
ductionhtm
9 Wiegmann DA Shappell SA A human
error approach to aviation accident
analysis The human factors analysis and
classification system Burlington VT
Ashgate Publishing Ltd 2003
10 Yu-Hsun Cheng Sheng-Hui Hung
Tung-Wen Ko et al An Analysis of the
Reliability and Validity of Human Factors
Analysis Classification System in Medical
Adverse Events Journal of Healthcare
Quality 20191370-76
11 Taiwan Joint Commission on Hospital
Accreditation Taiwan Patient-Safety
Reporting System Annual Report 2017
New Taipei City Taiwan
12 Taiwan Patient Safety Net
httpwwwpatientsafetymohwgovtwCo
ntentzMessagesslistaspxSiteID=1ampMm
mID=621273300317401756
13 Government of Western Australia
Department of Health
httpsww2healthwagovauArticlesS_T
Severity-assessment-codes
14 Farley DO Haviland A Champagne S et
al Adverse-event-reporting practices by
US hospitals results of a national survey
Qual Saf Health Care 200817416-423
15 Shojania KG Thomas EJ Trends in
adverse events over time why are we not
improving BMJ Qual Saf
201322273-277
16 Levitt P Challenging the systems approach
why adverse event rates are not improving
BMJ Qual Saf 2014231051-1052
17 Kellogg KM Hettinger Z Shah M et al
Our current approach to root cause
analysis is it contributing to our failure to
improve patient safety BMJ Qual Saf
201726381-387
18 Khorsandi M Skouras C Beatson K et al
Quality review of an adverse incident
reporting system and root cause analysis of
serious adverse surgical incidents in a
teaching hospital of Scotland Patient Saf
Surg 2012621
19 Diller T Helmrich G Dunning S et al
The Human Factors Analysis
Classification System (HFACS) Applied to
Health Care Am J Med Qual
201429181-190
20 Carayon P Xie A Kianfar S Human
factors and ergonomics as a patient safety
practice BMJ Qual Saf 201423196-205
21 Reason J Human Error New York
Cambridge University Press 1990
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 104
TABLE
Table 1 Incidences by Category (N=40)
CategorySAC SAC 4 SAC 3 SAC 2 SAC 1 total
Laboratory and ex-
amination events
4 10 2 0 16 (400)
Clinical care event 6 2 1 0 9 (225)
Medication event 5 0 2 0 7 (175)
Surgery-related event 1 1 2 0 4 (100)
Transfusion-related
event
1 1 0 0 2 (50)
Tube event 0 1 0 0 1 (25)
Public accident 0 0 1 0 1 (26)
Total 17 (425) 15 (375) 8 (200) 0 40 (100)
SAC 1113 Severity Assessment Code SAC
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 105
FIGURES
Figure 1 Active Failures (N=40)
16 (167)
66 (1000)
640 (150)
235 (57)
735 (200)
2435 (686)
2435 (686)
3540 (875)
438 (105)
438 (105)
738 (184)
1938 (500)
3138 (816)
3840 (950)
0 5 10 15 20 25 30 35 40
Commits WidespreadRoutine Violation
Performs Work-Around Violation
Ignored a CautionWarning
Failure to Prioritize Tasks Adequately
Wrong Choice of Action During an Operation
Inadequate Real‐Time Risk Assessment
Rushed or Delayed a Necessary Action
Breakdown in Visual Scan
Over-ControlledUnder-Controlled AircraftVehicleSystem
Unintended Operation of Equipment
Procedure Not Followed Correctly
Performance-Based Errors
Judgment and Decision Making Errors
Violations
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 106
Figure 2 Preconditions (Latent Failures or Conditions) (N=40)
14 (250)
24 (500)
48 (500)
11 (1000)
18 (125)
840 (200)
0 5 10 15 20 25 30 35 40
Seat and Restraint System Problems
Instrumentation amp Warning System Issues
Noise Interference
Environment
Physical Environment
Technological Environment
27 (286)
27 (286)
27 (286)
37 (129)
47 (511)
47 (571)
77 (1000)
24 (500)
44 (1000)
47 (571)
12 (500)
22 (1000)
27 (286)
740 (175)
0 5 10 15 20 25 30 35 40
Technical or Procedural Knowledge Not Retained After Training
InterferenceInterruption
Task OverUnder Saturation
Distraction
Negative Habit Transfer
Not Paying Attention
Complacency
Overconfidence
Physical IllnessInjury
Fatigue
Physical and Mental State
Physical Problem
State of Mind
Mental Awareness
211 (182)
311 (273)
311 (273)
411 (364)
811 (7227)
911 (818)
1140 (275)
0 5 10 15 20 25 30 35 40
Inadequate Task Delegation
TaskMission PlanningBriefingDebriefing Inadequate
Failure of CrewTeam Leadership
StandardProper Terminology Not Used
Critical Information Not Communicated
Failed to Effectively Communicate
Teamwork
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 107
Figure 3 Supervision (Direct Supervisory Chain of Command) (N=40)
Figure 4 Organization Influence (Upper-Level Management Command Level) (N=40)
114 (71)
114 (71)
214 (143)
314 (214)
1314 (929)
1440 (350)
511 (455)
511 (455)
711 (636)
1140 (275)
47 (571)
67 (857)
740 (175)
0 5 10 15 20 25 30 35 40
Selected Individual with Lack of Proficiency
Improper Role‐modeling
Failed to Provide Proper Training
Failed to IdentifyCorrect Risky or Unsafe Practices
SupervisoryCommand Oversight Inadequate
Performed Inadequate Risk Assessment ‐Formal
Selected Individual with Lack of Current or Limited Experience
Authorized Unnecessary Hazard
Allowing Unwritten Policies to Become Standard
Failure to Enforce Existing Rules
Supervisory Violations
Planned Inappropriate Operations
Inadequate Supervision
12 (500)
12 (500)
240 (50)
110 (100)
510 (500)
1040 (250)
11 (1000)
140 (25)
18 (125)
18 (125)
38 (35)
48 (500)
840 (200)
0 5 10 15 20 25 30 35 40
Organizational Over-confidence or Under-confidence in Equipment
Organizational Culture (attitude actions) Allows for Unsafe TaskMission
Purchasing or Providing Poorly Designed or Unsuitable Equipment
Organizational ProgramPolicy Risks not Adequately Assessed
Failure to Provide Adequate Manning Staffing Resources
Failure to remove inadequate worn-out equipment in timely manner
Inadequate infrastructure
Command and control resources are deficient
Failure to provide adequate operational information resources
Resource Problems
Personnel Selection amp Staffing
Policy and Process Issues
ClimateCulture Influences
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 108
Supplement Table 1- HFACS Content of Human Factor Analysis Classifi-
cation System [9] Tier main level sub-item nano code
Tier 1 Unsafe Acts
Perfor-
mance-Based
Errors
Unintended operation of equipment
Checklist not followed correctly
Procedure not followed correctly
Over-controlledunder-controlled aircraftvehiclesystem
Breakdown in visual scan
Rushed or delayed a necessary action
Judgment amp De-
cision-Making
Errors
Inadequate real‐time risk assessment
Failure to prioritize tasks adequately
Ignored a cautionwarning
Wrong choice of action during an operation
Violations
Performs work-around violation
Commits widespreadroutine violation
Extreme violation-lack of discipline
Tier 2 Preconditions
Environment
Physical environment
Environmental conditions affecting vision
Vibration effects vision or balance
Heatcold stress impairs performance
External force of object impeded an individualrsquos
movement
Lights of other vehiclevesselaircraft affected vision
Noise interference
Technological environment
Seat and restraint system problems
Instrumentation amp warning system issues
Visibility restrictions (not weather related)
Controls and switches are inadequate
Automated system creates unsafe situation
Workspace incompatible with operation
Personal equipment interference
Communication equipment inadequate
Physical and
Mental State
Physical problem
Substance effects (alcohol supplements medications
drugs)
Loss of consciousness (sudden or prolonged onset)
Physical illnessinjury
Fatigue
Inadequate adaptation to darkness
Dehydration
Body sizemovement limitations
Physical strength amp coordination (inappropriate for
task demands)
Nutritiondiet
State of mind
Psychological problem
Life stressors
Emotional state
Personality style
Overconfidence
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 109
Pressing
Complacency
Motivation
Motivational exhaustion (burnout)
Sensory misperception
Motion illusion-kinesthetic
Turning illusionbalance-vestibular
Visual illusion
Misperception of changing environment
Misinterpreted misread instrument
Misinterpretation of auditorysound cues
Spatial disorientation
Temporaltime distortion
Mental awareness
Not paying attention
Fixation
Task overunder saturation
Confusion
Negative habit transfer
Distraction
Geographically lost
Interferenceinterruption
Technical or procedural knowledge not retained after
training
Inaccurate expectation
Teamwork
Failure of crewteam leadership
Inadequate task delegation
Rankposition intimidation
Lack of assertiveness
Critical information not communicated
Standardproper terminology not used
Failed to effectively communicate
Taskmission planningbriefingdebriefing inadequate
Tier 3 Supervision
Supervisory Vio-
lations
Failure to enforce existing rules
Allowing unwritten policies to become standard
Directed individual to violate existing regulations
Authorized unqualified individuals for task
Planned Inappro-
priate Operations
Directed task beyond personnel capabilities
Inappropriate team composition
Selected individual with lack of current or limited experience
Performed inadequate risk assessment ‐formal
Authorized unnecessary hazard
Inadequate Su-
pervision
Supervisorycommand oversight inadequate
Improper role‐modeling
Failed to provide proper training
Failed to provide appropriate policyguidance
Personality conflict with supervisor
Lack of supervisory responses to critical information
Failed to identifycorrect risky or unsafe practices
Selected individual with lack of proficiency
Tier 4 Organizational
Influences
Resource Prob-
lems
Command and control resources are deficient
Inadequate infrastructure
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 110
Failure to remove inadequate worn-out equipment in timely
manner
Failure to provide adequate operational information resources
Fail to provide adequate funding
Personnel Selec-
tion amp Staffing
Personnel recruiting amp selection policies are inadequate
Failure to provide adequate manning staffing resources
Policy amp Process
Issues
Pace of ops-tempoworkload
Organizational programpolicy risks not adequately assessed
Provided inadequate procedural guidance or publications
Organizational (formal) training is inadequate or unavailable
Flawed doctrinephilosophy
Inadequate program management
Purchasing or providing poorly designed or unsuitable equip-
ment
ClimateCulture
Influences
Organizational culture (attitude actions) allows for unsafe
taskmission
Organizational over-confidence or under-confidence in equip-
ment
Unit missionaircraftvehicleequipment change or unit deacti-
vation
Organizational structure is unclear or inadequate
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 111
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
以 HFACS重新檢視根本原因分析案例挖掘造成醫療不良
事件之人為因素
鄭伃洵 1洪聖惠 12柯彤文 3王拔群 14
中文摘要
背景醫療不良事件(AMEs)的管理是促進病人安全的基石根本原因分析
(RCA)是探討重大病人安全不良事件問題但是由於無法解釋更廣泛的因素而受
到限制本研究使用人為因素分類與分析工具(HFACS)回溯審視醫療不良事件
以了解影響醫療不良事件的人為因素及各層面中錯誤原因之分佈或系統性問題
方法本研究回溯 2012-2016年間有做過根本原因分析之醫療不良事件以連續
性取樣方式(continuous sampling)收集 40例醫療不良事件以人為因素分類與分
析工具(HFACS)去系統性的挖掘每件案例發生錯誤之原因結果在行為層面中
分析結果主要為基礎技能錯誤(95)判斷和決策錯誤(875)其中在基礎技能
錯誤當中以未依程序作業執行(816)及未如預期設備操作(50)佔多數判斷和
決策錯誤中以現場風險評估不確實(686)及採取錯的步驟行為(686)佔多數
而在先決條件層面中以團隊合作(275)為主要因素包含溝通不良(818)及重
要訊息未以正確的方式即時傳達(727)佔多數在監督層面當中以監督不周
(929)或監督不妥當(929)為主要因素在組織政策和流程方面(50)以組織
系統的政策風險未充分評估(35)為主要因素結論本研究進一步了解醫療不
良事件在過去使用根本原因分析未探討到的人為因素反映出潛在的監督組織
行為或系統性的問題促進病人安全預防錯誤再發生
關鍵字病人安全醫療不良事件根本原因分析人為因素
1國泰醫療財團法人國泰綜合醫院 品質管理部
2國立臺灣大學健康政策與管理研究所
3振興醫療財團法人振興醫院 醫療品質管理中心
4輔仁大學醫學院
通訊作者王拔群 電子信箱 drtonyseednettw
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin 112
Submitted January 20 2020
Final version accepted April13
2020
Case Report
Juvenile Caruncular Atypical Lymphoid
Proliferation ndash A Rare Case Report
Cite as Hua-Wei Shih Yu-Chi Lin
Juvenile Caruncular Atypical
Lymphoid Proliferation ndash A Rare
Case Report Fu-Jen Journal of
Medicine 3(3) 112-119 2020
DOI
103966181020932020091803003
Hua-Wei Shih1 Yu-Chi Lin
1
1Department of Ophthalmology Shin Kong Wu Ho-Su Memorial Hos-
pital Taipei City Taiwan
Corresponding author E-mail address
yuchi067gmailcom (Yu-Chi Lin)
ABSTRACT
Lesions of the caruncle are very rare Most caruncular lesions are benign though there were still few reported malignant lesions Ocular adnexal lymphoproliferative disease (OALD) one of the differential diagnosis of caruncular lesion is seldom seen in young pa-tient In this article we report a 16-year-old boy with recurrent caruncular atypical lym-phoid proliferation We discuss the epidemiology clinical features images histomorpholo-gy and treatment between ocular adnexal lymphomas (OAL) and reactive lymphoid hyper-plasia (RLH)
Keywords caruncular lesion ocular adnexal lymphoproliferative disease ocular adnexal lymphoma
reactive lymphoid hyperplasia atypical lymphoid proliferation
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
113
INTRODUCTION Lesions of the caruncle are very rare Differen-
tial diagnosis includes nevus myeloproliferative
disorders tumors inflammation infection cysts
vascular lesions and fibrous Biopsy is essential
for diagnosis Levy J et al reported ocular ad-
nexal lymphoproliferative disease (OALD) was
relatively uncommon diagnosis among caruncu-
lar lesions [1]
OALD was seldom described in Asian popula-
tion especially for young age C-Y Cheng re-
ported age-standardized incidence of ocular
adnexal lymphomas (OAL) in Taiwan from 1979
to 1996 was below 07 per million per year and
mean age was 531 years old [2] In 2015 five
Taiwanese cases of OAL whose age ranging
from 45 to 64 were presented [3] However
there were few cases of conjunctival OAL or
RLH in Chinese pediatric patient
Here we present a case of 16-year-old boy with a
caruncular mass at his left eye with recurrence
one month after excision We describe his clini-
cal symptoms photographs pathological results
management and follow-up clinical course in
this report
CASE REPORT A 16-year-old healthy boy presented a mass
lesion at his left eye caruncle accompanied with
the symptom of tearing for one month (Figure 1)
He had no ocular pain no itchiness no blurred
vision no night sweating no fever and no body
weight loss The patient denied systemic diseas-
es and histories of surgery His bilateral best
corrected visual acuity (BCVA) were 66 and
intraocular pressure (IOP) were both within
normal range There were no remarkable find-
ings for his cornea lens fundus and physical
examination Excision was performed and the
mass was soft with fluid inside therefore con-
junctival pyogenic cyst was our initial diagnosis
However one month after the excision a pro-
truding mass recurred at the patientrsquos nasal can-
thus of left eye (Figure 2) There were some
differences compared to previous condition At
the first time the soft mass was contained in a
well-defined cyst wall which more favored py-
ogenic granulation However after short period
of recurrence solid consistency and unclear
margin were found which favored malignancy
Besides the mass partially involved beyond the
gray line of nasal part lower eyelid whereas last
time the cyst mainly extended from conjunctiva
of caruncle The second excisional biopsy was
performed Pathologic examination demonstrat-
ed abundant atypical lymphoid proliferation
(Figure 3A 3B) Immunohistochemical studies
showed that the lymphoid aggregation was
composed predominantly of CD20-positive cells
(Figure 3C) focal positive staining of CD3
(Figure 3D) CD5 CD23 CD10 and negative
staining of cyclin-D1 Unfortunately the cellular
morphology was difficult to be evaluated due to
marked crushing artifact Thus malignant lym-
phoma cannot be excluded totally
Orbital computed tomography (CT) showed a
lesion of soft tissue density at medial canthus of
left orbit without obvious nasolacrimal duct or
bony invasion (Figure 4A) Magnetic resonance
imaging (MRI) with contrast showed strong
enhancement at left medial canthus region (Fig-
ure 4B) There was no remarkable finding in the
systemic workup including complete blood
count and differential count biochemical pro-
files and 18F-fluoro-2-deoxyglucose positron
emission tomographycomputed tomography
(18F-FDG PETCT) indicating no evidence of
systemic involvement
After the second excision we preferred con-
servative management for him due to the uncer-
tainty of malignancy and to avoid side effects
from aggressive treatment No sign of recurrence
was noted after 10 months of observation The
follow-up photo was taken at three months after
the second operation (Figure 5)
DISCUSSION Ocular adnexal lymphoproliferative disease
(OALD) consists of the spectrum of lymphoid
disease affecting the tissues surrounding the eye
including ocular adnexal lymphomas (OAL) and
lymphoid hyperplasia (LH) [4] The conjunctiva
is an important location for extranodal lympho-
ma development which comprises 25 of OAL
[5]
OAL can be grouped into two categories based
on their appearance of cells under the micro-
scope low-grade and high-grade [6] Extranodal
marginal zone lymphoma of mucosa-associated
lymphoid tissue (EMZLMALT) is the most
common subtype of OAL followed by follicular
lymphoma [7-9] Both of the above are
low-grade lymphomas
LH can be further divided by histopathology into
reactive lymphoid hyperplasia (RLH) and atypi-
cal lymphoid hyperplasia (ALH) RLH has to-
tally benign morphology and immunophenotype
whereas ALH has borderline lesions between
RLH and lymphoma [10] OAL and LH are
mostly seen in patients with age between 50-70
years old There are rare cases in pediatric group
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
114
[71011] In the C-Y Chengrsquos statistical report of
OAL in Taiwan only 8 patients were younger
than 15 years old among the 101 cases of ocular
lymphoma [2] According to an US study inci-
dence rates of OAL were analyzed in different
age groups the group of age over 50 had the
highest incidence rate of 574 per million per-
son-years while the 0-19 age group had the
lowest incidence rate of 009 per million per-
son-years [12] The incidence of LH was even
less than OAL [13]
Patients with OALD may be asymptomatic or
with symptoms of proptosis eyelid swelling a
palpable painless mass or conjunctival salmon
patch Diplopia visual loss pain or inflamma-
tion occurred less frequently implying more
aggressive features [714]
Orbital LH is not distinguishable from low-grade
lymphoma radiologically They both typically
present a round or lobulated mass that diffusely
moderately enhances with contrast and usually
shows homogenous hypointense or isointense to
muscle barely invasion to bone or nervous sys-
tem [10] Atypical appearances including inho-
mogeneous calcification or bony changes may
be seen in high-grade lymphoma case reports
such as ocular adnexal diffuse large B-cell lym-
phoma (DLBCL) which is one of the more ag-
gressive type of OAL [7] Whole body PET is
used for not only the evaluation of systemic
involvement but also the standard for staging
lymphoma Our patientrsquos image studies revealed
neither obvious local invasion nor systemic ma-
lignancy indicating high-grade lymphoma was
less likely Low-grade lymphoma and benign
reactive lymphoid hyperplasia were still under
consideration
Histomorphology analysis and immunohisto-
chemistry (IHC) are essential for diagnosis
Flow cytometry and polymerase chain reaction
(PCR) technique are also applied to help differ-
entiate from RLH and OAL [1016] Our case
had immunohistochemical profile of positivity
for CD20 predominantly positivity focally for
CD3 CD5 CD10 CD23 and negativity for cy-
clin-D1 BCL-6 staining was not performed in
our casersquos biopsy Thus according to the IHC
report RLH ALH and follicular lymphoma are
probable diagnosis of our patient
Radiation therapy is the standard treatment for
low-grade OAL that is classified as T1N0M0 or
T2N0M0 according to the AJCC criteria [15]
İncesoy-Ouml zdemir S et al reported a 10-year-old
boy diagnosed of MALT lymphoma who was
treated with local radiotherapy (36 Gy) and
there were no local or systemic recurrences dur-
ing his nearly four-year follow-up [17] Another
case report represented a 21-year-old man of
conjunctival follicular lymphoma treated with
surgical excision only showing no evidence of
recurrence after 8 months follow-up [18] Other
treatment options for pediatric and juvenile OAL
were performed in some case reports including
intravenous rituximab intralesional interfer-
on-α-2b topical interferon a6 systemic doxycy-
cline surgical excision and postoperative local
cryotherapy [15]
Treatment for young conjunctival RLH was less
discussed in the past In a case series article
three children (9 13 14 years old respectively)
of RLH received surgical resection without fur-
ther postoperative management and no signs of
recurrence were noted during follow-up [19]
Short-term topical and oral corticosteroids after
surgical excision were prescribed in two pediat-
ric RLH patients for their small residual mass
However poor response in both cases was nota-
ble [20]
Our patient declined to receive radiotherapy or
any further postoperative treatment mainly due
to his concerning of possible side effects (such
as dry eye and cataract)
CONCLUSION We present a rare case of caruncle mass in this
report OALD is one of the relatively uncommon
diagnosis among caruncular lesions OALD
includes benign RLH and malignant OAL
which are both mainly seen in elderly patients
even rarer in pediatric or juvenile group
The standard treatment for low-grade OAL and
RLH in young patents are still debatable How-
ever long-term follow-up is suggested for both
OAL and RLH patients Though RLH has a be-
nign and self-limited course risk of malignant
transformation is possible
REFERENCES 1 Levy J Ilsar M Deckel Y et al Lesions of
the caruncle a description of 42 cases and
a review of the literature Eye
200923(5)1004-1018
2 C-Y Cheng and W-M Hsu Incidence of
eye cancer in Taiwan an 18-year review
Eye 200418152-158
3 Chui-Lien Tsen Muh-Chiou Lin
Youn-Shen Bee et al Ocular adnexal
lymphoma Five case reports and a
literature review Taiwan Journal of
Ophthalmology 20155(2)99-102
4 Liesegang TJ Ocular adnexal
lymphoproliferative lesions Mayo Clin
Proc 199368(10)1003-1010
5 Kirkegaard MM Coupland SE Prause JU
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
115
et al Malignant lymphoma of the
conjunctiva Surv Ophthalmol
201560(5)444-458
6 Stacy RC Jakobiec FA Schoenfield L et
al Unifocal and multifocal reactive
lymphoid hyperplasia vs follicular
lymphoma of the ocular adnexa Am J
Ophthalmol 2010150(3)412-426
7 Sullivan TJ Ocular Adnexal
Lymphoproliferative Disease In Guthoff
RF Katowitz JA eds Oculoplastics and
Orbit Berlin Heidelberg Springer
20101-19
8 White Valerie A Understanding and
Classification of Ocular Lymphomas
Ocular Oncology and Pathology
20195379-386
9 Stefanovic A Lossos IS Extranodal
marginal zone lymphoma of the ocular
adnexa Blood 2009114(3)501-510
10 Andrew NH Coupland SE Pirbhai A et al
Lymphoid hyperplasia of the orbit and
ocular adnexa A clinical pathologic review
Surv Ophthalmol 201661(6)778-790
11 Ferry JA1 Fung CY Zukerberg L et al
Lymphoma of the ocular adnexa A study
of 353 cases Am J Surg Pathol
200731(2)170-184
12 WM Hassan MS Bakry HM Hassan et al
Incidence of orbital conjunctival and
lacrimal gland malignant tumors in USA
from Surveillance Epidemiology and End
Results 1973-2009 Int J Ophthalmol
20169(12)1808-1813
13 Ajay A Rao John H Naheedy James Y-Y
Chen et al A Clinical Update and
Radiologic Review of Pediatric Orbital
and Ocular Tumors Journal of Oncology
2013(9)975908
14 Sullivan TJ Whitehead K Williamson R
et al Lymphoproliferative disease of the
ocular adnexa a clinical and pathologic
study with statistical analysis of 69
patients Ophthal Plast Reconstr Surg
200521177-188
15 Tanenbaum RE Galor A Dubovy SR et al
Classification diagnosis and management
of conjunctival lymphoma Eye Vis (Lond)
2019622
16 Olga Klavdianou Georgios Kondylis
Vasileios Georgopoulos et al Bilateral
benign reactive lymphoid hyperplasia of
the conjunctiva a case treated with oral
doxycycline and review of the literature
Eye Vis (Lond) 2019626
17 İncesoy-Ouml zdemir S Yuumlksek N Bozkurt C
et al A rare type of cancer in children
extranodal marginal zone B-cell (MALT)
lymphoma of the ocular adnexa Turk J
Pediatr 201456(3)295-298
18 Lynn J Poole Perry Frederick A Jakobiec
Peter A D Rubin Conjunctival Pediatric
Follicular Lymphoma Arch Ophthalmol
2012130(7)941-943
19 Abdullah Al-Mujaini Upender Wali
Anuradha Ganesh1 et al Ocular Adnexal
Reactive Lymphoid Hyperplasia in
Children Middle East Afr J Ophthalmol
201219(4)406-409
20 McLeod SD Edward DP Benign
lymphoid hyperplasia of the conjunctiva in
children Arch Ophthalmol
1999117(6)832-835
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
116
FIGURES
Figure 1 Slit lamp image of a mass lesion at the patientrsquos left eye caruncle for one month
Figure 2 One month after the first excision a protruding mass recurred at the patientrsquos nasal canthus
of left eye It partially involved beyond the gray line of nasal part lower eyelid
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
117
Figure 3 Histomorphology analysis and immunohistochemistry study of the caruncular lesion Abun-
dant atypical lymphoid proliferation presented in low-power photomicrograph (A) and
high-power photomicrograph (B) under hematoxylin-eosin staining The lymphoid aggrega-
tion was composed predominantly of CD20-positive cells (C) and focal positive staining of
CD3 (D)
Figure 4 Non-contrast orbital computed tomography showed a lesion of soft tissue density at medial
canthus of left orbit without obvious nasolacrimal duct or bony invasion (A) Magnetic reso-
nance imaging with contrast showed strong enhancement at left medial canthus region (B)
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
118
Figure 5 The follow-up photo were taken at three months after the second excision showing no signs
of recurrence
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
119
Juvenile Caruncular Atypical Lymphoid Proliferation ndash A Rare Case Report
罕見病例報告mdash青少年之淚阜非典型淋巴增生
施驊瑋 1林友祺 1
中文摘要
淚阜病灶相當罕見大部分為良性病灶眼睛及附屬結構淋巴增生疾病為其
鑑別診斷之一非常少見於年輕人或兒童我們報告一位 16歲的健康男性因
左眼淚阜無痛性腫塊接受切除手術卻於術後一個月復發執行第二次切除手術
後門診追蹤十個月未再復發此案例表現了部分良性與部分惡性腫瘤的特徵
我們針對反應性淋巴增生眼睛及附屬結構淋巴癌兩個疾病做討論及文獻回顧
關鍵字淚阜病灶眼睛及附屬結構淋巴增生疾病眼睛及附屬結構淋巴癌反
應性淋巴增生非典型淋巴增生
1 新光吳火獅紀念醫院眼科
通訊作者林友祺 電子信箱 yuchi067gmailcom
Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh 120
Submitted March 26 2020
Final version accepted April 16
2020
Case Report
Hyperacute intramembranous hemor-
rhage after burr hole craniostomy for
chronic subdural hematoma
Cite as Meng-Chi Lin Jui-Ming
Sun Yu-Hao Chen Cheng-Ta
Hsieh
Hyperacute intramembranous
hemorrhage after burr hole crani-
ostomy for chronic subdural he-
matoma Fu-Jen Journal of Medi-
cine 3(4) 120-125 2020
DOI
103966181020932020091803004
Meng-Chi Lin1 Jui-Ming Sun23 Yu-Hao Chen24 Cheng-Ta
Hsieh567
1Department of Surgery Zuoying Branch Kaohsiung Armed Forces
General Hospital Kaohsiung 813 Taiwan 2Section of Neurosurgery Department of Surgery Chia-Yi Christian
Hospital Chia-Yi City 600 Taiwan 3Department of Biotechnology Asia University Taichung City 41354
Taiwan 4Chung-Jen Junior College of Nursing Health Sciences and Manage-
ment Chia-Yi Country 62241 Taiwan 5Division of Neurosurgery Department of Surgery Sijhih Cathay Gen-
eral Hospital New Taipei City 22174 Taiwan 6Department of Medicine School of Medicine Fu Jen Catholic Univer-
sity New Taipei City 24205 Taiwan 7Department of Neurological Surgery Tri-Service General Hospital
National Defense Medical Center Taipei 114 Taiwan
Corresponding author E-mail address
nogormail2000comtw (Cheng-Ta Hsieh)
ABSTRACT
Burr hole craniostomy with closed-system drainage is an effective and common neurosurgical procedure to manage chronic subdural hematoma Postoperative hem-orrhage a well-known but infrequent complication may result in increased neurolog-ical deficits However hyperacute intramembranous hemorrhage within the inner and outer membrane of hematoma after burr hole craniostomy with irrigation and closed-system drainage has not been described previously Herein we report a case of postoperative spontaneous hyperacute intramembranous hemorrhage after burr hole craniostomy with closed-system drainage to manage a chronic subdural hematoma we subsequently discuss the possible pathophysiological mechanisms and review the relevant literature
Keywords Chronic subdural hematoma acute subdural hematoma bleeding burr hole craniostomy
drainage
Fu-J
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ASE REPO1-year-old wo
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of Medicine V
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CTION hematoma (C
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[4 6 7] Horanous bleedinCSDH has rarewe report the
developed spranous hemory Subsequenal mechanismis reviewed
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ma lucidum freferred to ouhe became proamination recale ratings wth score in thethe Medical R
atory examinaanges with no
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h irrigation a
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brane of the
Vol 3 No 4 2
Acute intram
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Fu-Jen Journal of Medicine Vol 3 No 4 2020
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125
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
慢性硬腦膜下出血進行鑽顱引流手術造成超急性夾膜內出
血
林孟楫 1孫瑞明 23陳昱豪 24謝政達 567
中文摘要
鑽顱併封閉系統引流手術是治療慢性硬腦膜下出血患者一種有效且常見的
神經外科手術方式術後出血可能導致神經功能缺損惡化是眾所周知但不常見
的併發症之一然而至今仍未有鑽孔併封閉系統引流造成原本慢性硬腦膜血
塊內膜和外膜間急性夾膜間出血案例在這裡我們報告一例慢性硬腦膜下出
血病患者接受鑽顱併封閉系統引流手術治療造成術後急性夾膜間出血我們在
本文中討論可能的致病機制並回顧相關文獻
關鍵字慢性硬腦膜下出血急性硬腦膜下出血出血鑽顱術引流
1國軍高雄總醫院左營分院 外科部
2崇仁醫護管理專科學校
3亞洲大學 生物科技學系
4戴德森醫療財團法人嘉義基督教醫院 外科部 神經外科
5汐止國泰綜合醫院 神經外科
6輔仁大學 醫學系
7 國防醫學院 三軍總醫院 神經外科
通訊作者謝政達 電子信箱 nogormail2000comtw
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
126
Submitted January 21 2020
Final version accepted July 08
2020
Case Report
Hamartoma of the breast A case report
Cite as Hsuan-An Chen
Cheng-Yu Lo Shih-Hung Huang
Chin-Lung Lin
Hamartoma of the breast A case
report Fu-Jen Journal of Medicine
3(5) 126-130 2020
DOI
103966181020932020091803005
Hsuan-An Chen1 Cheng-Yu Lo
3 Shih-Hung Huang
3 Chin-Lung
Lin2
1Department of Surgery Cathay General Hospital Taipei Taiwan
2Department of General Surgery Cathay General Hospital Taipei Tai-
wan
3Department of Pathology Cathay General Hospital Taipei Taiwan
Corresponding author E-mail address
lungyungmailcom (Chin-Lung Lin)
ABSTRACT
Breast hamartoma is an uncommon benign tumor rarely associated with malignancy An
excision and histological examination is necessary for the differential diagnosis We report
a case of a 49-year-old female patient presenting with a lump in the right breast Ultrasound
examination which demonstrated a 4411 cm hypoechoic lesion with lipoma Partial mas-
tectomy was arranged and the diagnosis of a hamartoma was confirmed by the histological
examination
Keywords Breast tumor Hamartoma Ultrasound
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
127
INTRODUCTION The hamartoma is a benign tumor-like lesion
that can affect various organs of the body in-
cluding lungs kidneys skin and more rarely the
breast In 1981 the hamartomas were recognized
in the WHO classification[1] They are defined
as well-demarcated mass of mammary ducts and
lobules containing varying amounts of fibrous
and adipose tissue and producing a distinctive
mammographic image
CASE REPORT A 49 year-old female had past history of left
breast mastitis with abscess status post partial
mastectomy This time she presented to our out
patient clinic for breast examination Physical
examination revealed a painless palpable mova-
ble and painless lump at upper outer quadrant of
right breast The risk of breast cancer was not
noted and the patient did not have any family
history of breast cancer The patient also denied
any trauma history before Ultrasound examina-
tion was arranged which demonstrated a 4411
cm hypoechoic lesion with lipoma at 3 oclock 2
cm from nipple of right breast and multiple hy-
poechoic nodules of various size in both breasts
and there was no suspicious axillary lymph
nodes noted (Figure1) Surgical treatment was
arranged partial mastectomy of right breast
harmartoma was successfully performed A 32 x
31 x 21 cm tumor was completely excised
Grossly examination showed a gray to yellow
and firm to fatty The diagnosis of a hamartoma
was confirmed by the histological examination
Microscopically sections of the breast lesion
show mammary hamartoma composed of ducts
lobules with interlobular fibrous tissue and adi-
pose tissue Fibrocystic change apocrine meta-
plastic ducts and scattered foci of adenosis are
noted The overall lobulocentric architecture and
the 2-cell pattern of the epithelium are preserved
columnar cell change and focal microcalcifica-
tion are present (Figure2) Based on submitted
biopsy specimen in-situ or invasive tumor cells
are not identified
DISCUSSION Hamartoma of the breast is a benign tumor like
nodule it was also known as fibroadenolipoma
lipofibroadenoma or adenolipoma based on its
predominant components It was composed of
varying amounts of glandular adipose and fi-
brous tissue[2] Hamartomas were first described
in 1971 by Arrigoni et al in a study of 10 patients
which breast tumors clinically and grossly re-
sembled fibroadenomas[3]
A higher predominance of tumors exists in fe-
males compared with males Hamartomas are
slowly-growing lesions with the diameter rang-
ing from 2 cm to 5 cm sometimes hamartomas
can reach giant diameter [4]
The clinical diagnosis of hamartoma is based on
the findings from mammography sonography
and histology examinations The hamartomas are
usually incidentally diagnosed by the women
older than 40 year-old starting mammography
screening
On physicial examination harmatomas are usu-
ally occult painless they may be as large mo-
bile soft to firm masses[5] Ultrasound showed
well capsulated mass with echogenic rim and
internal heterogeneity Mammography exam
showed well-circumscribed round to oval
masses containing fat and soft tissue densities
with a thin radiopaque pseudocapsule The
pseudocapsule results from displacement of
breast parenchyma by the tumor [56] In Pa-
thology finding microglandular adenosis is pre-
sent in fibroadipose stroma surrounded by a thin
fibrous capsule It composed of a combination of
epithelial and stromal elements usually with
normal ducts or lobules although variations of
normal tissue may also be seen Fibroadenoli-
poma myoid hamartoma and chondrolipoma are
histological variations of hamartomas depend-
ing on the proportion of normal breast tissue
elements[7]
Malignancy associated with hamartomas are
very rare[8] However it has been reported
hamartomas develop into carcinoma Malignant
transformation can occur as a result of cellular
atypia in the epithelial component of the mass[9]
Surgical removal is the curative method for
breast hamartomas[10] Diagnostic material such
as mammography ultrasonography or core nee-
dle biopsy may not give the definitive diagnosis
Therefore surgical excision and histological
examination is necessary for differential diagno-
sis[111213]
Although it is rare hamartoma can be seen along
with malignancy as it is formed from similar
components of breast tissue Therefore careful
diagnosis and appropriate management including
surgery are required
REFERENCES 1 World Health Organization (1981)
Histological typing of breast tumors In
International histological classification of
tumors 1981 2nd ed
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
128
2 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11435ndash449
2006
3 ArrigoniMG DockertyMB JuddES
The identificationand treatment of
mammary hamartoma Surg Gynecol
Obstet1971 133 577-82
4 Sanal HT Ersoz N Altinel O Unal E Can
C Giant hamartoma of the breast Breast J
2006 12 84-85
5 Feder JM de Paredes ES Hogge JP
Wilken JJ Unusual breast lesions
radiologic-pathologic correlation
Radiographics 1999 19S11ndashS26
6 Murat A Ozdemir H Yildirim H Poyraz
AK Ozercan R Hamartoma of the breast
Australas Radiol 200751 Spec NoB37ndash
9
7 Fisher CJ Hanby AM Robinson L Millis
RR Mammary hamartoma-a review of 35
cases Histopathology 1992 20 99-106
8 Choi N Ko ES Invasive ductal carcinoma
in a mammary hamartoma case report and
review of the literature Korean J Radiol
2010 Nov-Dec11(6)687-91
9 Lee EH Wylie EJ Bourke AG Bastiaan
De Boer W Invasive ductal carcinoma
arising in a breast hamartoma two case
reports and a review of the literature Clin
Radiol 2003 58 80-3
10 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11 435 ‑449
2006
11 Coyne J Hobbs FM Boggis C Harland R
Lobular carcinoma in a mammary
hamartoma J Clin Pathol 199245936ndash
937
12 G M K Tse B K B Law T K F Ma A B W
Chan Hamartoma of the breast a
clinicopathological review J Clin Pathol
200255951ndash954
13 RAAmir SSheikh BreasthamartomaA
report of 14cases of an under-recognized
and under-reported entity International
Journal of Surgery Case Reports
22(2016)1ndash4
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
129
FIGURES
Figure 1 Ultrasound shows a 4411 cm hypoechoic lesion with lipoma at 3 oclock 2 cm from nipple
of right breast
Figure 2 Photomicrograph shows mammary hamartoma composed of ducts lobules with interlobular
fibrous tissue and adipose tissue
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
130
Hamartoma of the breast A case report
乳房錯構瘤罕見個案報告
陳宣安 1羅承裕 3黃世鴻 3林錦龍 2
中文摘要
乳房錯構瘤是一種罕見之乳房良性腫瘤切除手術及病理化驗來做鑑別診斷
我們報告一位 49歲女性以可觸摸到無痛性右側乳房腫塊為臨床表徵超音波
看到一個邊緣清楚低迴音的腫塊病患接受手術切除病灶病理診斷證實為乳
房錯構瘤
關鍵字乳房腫瘤錯構瘤超音波攝影
1國泰綜合醫院外科部
2國泰綜合醫院一般外科
3國泰綜合醫院病理科
通訊作者林錦龍 電子信箱 lungyungmailcom
Fu-Jen Journal of Medicine
Mission and Goals
The Fu-Jen Journal of Medicine (FJJM) is a peer-reviewed journal which
aims to enhance research quality of staffs in the College of Medicine Fu Jen
Catholic University The journal publishes original investigations across a
wide range of medical disciplines including original research articles in basic
and clinical sciences case reports review articles brief reports and letter
to the editor FJJM is now issued by the Center of Medical Education in the
College of Medicine Fu Jen Catholic University To promote journal quality
the manuscript submitted to FJJM after August first 2015 has to be prepared
in English to meet the international standards
Issue Date
Publication Date
Institution
December 01 2003
September 30 2020
College of Medicine Fu Jen Catholic University
Honorable publisher Han-Sun Chiang
Publisher Ping-Keung Yip
Editor-in-chief Ming-Chieh Ma
Associate Editors Yu-Wen Lin
Editors
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Address Center for Medical Education College of Medicine Fu Jen
Catholic University
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Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang
99
Submitted October 11 2019
Final version accepted February
02 2020
Original Research Article
Human Factors Underlying Adverse
Medical Events Revisit Root Cause Anal-
ysis Cases Using the HFACS
Cite as Yu-Hsun Cheng
Sheng-Hui Hung Tung-Wen Ko
Pa-Chun Wang
Human Factors Underlying Ad-
verse Medical Events Revisit
Root Cause Analysis Cases Using
the HFACS Fu-Jen Journal of
Medicine 3(2) 99-111 2020
DOI
103966181020932020091803002
Yu-Hsun Cheng1 Sheng-Hui Hung
12 Tung-Wen Ko
3 Pa-Chun
Wang14
1Department of Quality Management Cathay General Hospital Taipei
Taiwan
2Institute of Health Policy and Management National Taiwan Universi-
ty Taipei Taiwan
3Center for Healthcare Quality Management Cheng Hsin General Hos-
pital Taipei Taiwan
4Fu Jen Catholic University School of Medicine New Taipei City Tai-
wan
Corresponding author E-mail address
drtonyseednettw (Pa-Chun Wang)
ABSTRACT Background Appropriate management of adverse medical events (AMEs) is the corner-
stone of patient safety Root cause analysis (RCA) is used to investigate serious or
high-frequency errors but is limited by its inability to explain a broader scope of factors
We re-reviewed RCA cases to understand the underlying human organizational or system-
ic factors affecting AMEs Methods A total of 40 consecutive RCA cases (2012-2016) were
retrieved from the AMEs database A panel was organized to retrospectively re-review these
cases using the Human Factor Analysis and Classification System HFACS Results For
active failures errors stemmed largely from performance-based (95) judgment and deci-
sion-making errors (875) Incorrectly followed procedures (816) and accidental
equipment operation (50) were the most common types of performance-based errors In-
adequate real-time assessment (686) and inappropriate operative actions (686) were
the most common decision-making errors For sources of latent failure teamwork problems
(275) including failure to effectively communicate (818) and communicate critical
information (727) were common Inadequate supervision (929) or command over-
sights (929) were the most common problems related to inadequate supervision (35)
Organizational programpolicy risks not adequately assessed (50) were the most common
problems related to policy and process problem (25) Conclusions The HFACS review
enhances our understanding of human factors underlying AMEs The HFACS reveals latent
supervisory organizational or systematic problems that cannot be addressed through tradi-
tional RCA Keywords patient safety adverse events root cause analysis human factors
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 100
INTRODUCTION Patient safety involves the reduction of patient
harm from potentially avoidable unintended
outcomes [1] Studies have revealed that 50ndash
80 of adverse medical events (AMEs) are pre-
ventable [2-4] to eliminate such errors the ap-
propriate management of AMEs hence repre-
sents the cornerstone of patient safety work
Through incident reporting investigation and
analysis healthcare providers can correct or
re-engineer their care processes to prevent inci-
dent recurrence [25] One of the most popular
tools for investigating AMEs is root cause anal-
ysis (RCA) RCA reconstructs a chain of errors
to identify the deviation of care from normal
processes Nonetheless with a lack of standard-
ized nomenclature and investigation procedures
RCA report conclusions are sometimes too sub-
jective and nonspecific to facilitate any actiona-
ble safety improvement plans [5-7] According
to the UK Health and Safety Executive defini-
tion human factors are environmental organiza-
tional occupational or individual human char-
acteristics which influence behavior at work
such that health and safety are affected [8] Hu-
mans and systems are prone to errors and stud-
ies have showed that nearly 70 of medical
errors involve human factors [2-4] Reasonrsquos
Swiss cheese model described the penetration of
causative human errors through layers of defen-
sive barriers leading to system collapse [9]
With much focus on the temporal sequence and
severity of departure from accepted practices in
an incident the effectiveness of RCA is often
challenged by its incapability of exploring un-
derlying human organization or even systemic
factors [5-7] Reason and others have proposed
that errors can occur at 4 levels 1) unsafe acts
(operator actions) 2) preconditions for unsafe
acts (environmental factors contributing to er-
rors) 3) inadequate supervision (management
actions affecting the operator) and 4) organiza-
tional influences (organizational culture policies
and procedures that affect the operator) [9]
Based on this theory Wiegmann and Shappell
developed the Human Factor Analysis Classifi-
cation System (HFACS) to describe human fac-
tors causing accidents from 4 tiers of categories
Each of these categories consists of nanocodes to
represent specific human behavior or system
problems leading to errors [9-10] The tier for
unsafe acts involves actual provider actions (er-
rors or rule violations) directly leading to events
The tier representing preconditions for unsafe
acts includes operational personnel and envi-
ronmental factors The supervision tier addresses
leadership problems operational planning fail-
ure or correction and supervisory ethics The
tier for organizational influences deals with re-
source management organizational climate and
operational processes (Supplement Table 1) The
HFACS provides standardized investigation
processes for the systematic analysis of common
causes of adverse events across national defense
nuclear power navy aviation and healthcare
industries Taiwan launched its nationwide
AME-reporting system the Taiwan Patient
Safety Reporting System (TPR) in 2004 RCA
methodology was subsequently introduced to the
healthcare industry by the Joint Commission of
Taiwan [11] Since 2012 appropriate manage-
ment of AMEs has been listed as a national pa-
tient safety goal [12] RCA is required by the
Ministry of Health and Welfare for major AMEs
Aside from RCA a comprehensive structural
reliable and valid framework is urgently re-
quired to further guide organizational or even
national patient safety policies In this study we
used the HFACS to review our RCA cases aim-
ing to investigate human factors underlying se-
vere or frequent AMEs
MATERIALS AND METHODS Through continuous sampling 40 consecutive
RCA cases (2012-2016) were retrieved from a
hospitalrsquos (Cathay General Hospital Taipei
Taiwan) AME-reporting system database The
database contains AMEs relating to areas such as
medication patient falls surgery transfusion
clinical care public accidents security hospital
violence tube-related complication unplanned
cardiopulmonary resuscitation laboratory testing
and examination and anesthesia The RCA cases
were sentinel or high-frequency events classified
according to severity assessment category (SAC)
[1113] The SAC is an evaluation method for
categorizing AMEs by severity of effect on pa-
tients health and risk of incident reoccurrence
The HFACS has been modified (from the US
Department of Defense version 70) and trans-
lated into Mandarin Chinese with authorization
from the original developers [10] The Chi-
nese-version HFACS for Taiwan is a valid in-
strument (content validity index 09 Cronbachrsquos
α gt07 interrater reliability Κ 04-10) equiva-
lent to the original English version [9] The
HFACS contains 4 tiers 13 subitems and 109
nanocodes (Supplement Table 1) A panel of 6
reviewers was established All reviewers were
from clinical or management (quality and patient
safety management) backgrounds Reviewers all
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 101
finished human factor education and were
trained to use the HFACS through a consensus
meeting Each RCA case was randomly assigned
to 2 reviewers Human factors leading to partic-
ular AMEs were identified and confirmed when
2 reviewers reached agreement The distribution
of errors among tiers subitems and nanocodes
are provided with descriptive statistics () The
study was approved by the Institutional Review
Board of Cathay General Hospital
(CGH-P105095)
RESULTS AMEs related to laboratory testing and examina-
tion (n = 16) clinical care (n = 9) and medica-
tion (n = 7) were the most commonly observed
in the RCA Most AMEs in this cohort are
ranked as being SAC level 3 (n = 15) or 4 (n =
17) (Table 1)
Acts (Active Failures)
This tier of errors contains 3 subitems and 13
nanocodes In the 40 RCA cases perfor-
mance-based errors for 38 (95) and judgment
and decision-making errors for 35 (875) com-
prised the most common error types with viola-
tion for 6 (15) less common Procedure fol-
lowed incorrectly for 31 out of 38 (816) was
the most common performance-based problem
Inadequate real-time risk management for 24 out
of 35 (686) was the most common judgment
or decision error All of the rule violations were
workaround types for 6 out of 6 (100) (Figure
1)
Preconditions(Latent Failures)
This tier of errors has 9 subitems and 58 nano-
codes In the 40 RCA cases teamwork for 11
(275) and environmental for 8 (20) factors
contributed to most of the errors with mental
and physical state the next most common factor
for 7 (175) Communication for 9 out of 11
(818) and information relay for 8 out of 11
(727) were the most common issues related to
teamwork Few contributors mentioned failures
related to technical errors for 4 (50) or physi-
cal for 1 (125) environment Not paying at-
tention for 4 out of 7 (571) and negative habit
transfer for 4 out of 7 (571) were common
mental contributes noted for 7 (100) Overcon-
fidence was the most common problem related
to emotional status for 4 out of 7 (571) Fa-
tigue was observed in only 2 cases for 2 out of 2
physical problems (100) (Figure 2)
Supervision(Direct Supervisory Chain of
Command)
This tier of errors contains 3 subitems and 17
nanocodes In the 40 RCA cases inadequate
supervision for 14 (35) and inappropriately
planned operations for 11 (275) factors con-
tributed to most of the respective errors fol-
lowed by supervisory violations for 7 (175)
Supervisory or command oversights for 13 out
of 14 (929) were the most common sources of
supervision inadequacy Authorized unnecessary
hazards for 7 out of 11 (636) were the most
common inappropriately planned operations
Failure to enforce rules for 6 out of 7 (857)
was the most common supervisory violation
(Figure 3)
Organization Influence (Upper-Level Man-
agement)
This tier of errors contains 4 subitems and 18
nanocodes In the 40 RCA cases policy and
process issues for 10 (25) and resources prob-
lem for 8 (20) were major concerns Few of
the respective problems are related to climate
and cultural influences for 2 (5) or to person-
nel selection and staffing for 1 (25) Poorly
assessed organizational programs or policy risks
for 5 out of 10 (50) were the most common
policy and process problems Failure to provide
adequate operational information resources for 4
out of 8 (50) and command and control re-
source deficiency for 3 out of 8 (375) were
the main resource management problems Little
was revealed regarding organizational climate
and culture (n = 1 out of 2 50) or staffing for 1
out of 1 (100) (Figure 4)
DISCUSSION Health care is a complex system comprising
many high-reliability organizations (HROs) The
vulnerability of HROs stems from the participa-
tion of multidisciplinary teams in the processes
along a variety of patient care timelines How-
ever humans and systems are inherently prone
to errors the appropriate management of AMEs
is acknowledged to be the cornerstone of patient
safety AMEs should be reported investigated
analyzed and handled appropriately[14] Theo-
retically by analyzing the pattern of key defects
providers can fix errors and re-engineer their
care processes to reduce the possibility of AME
recurrence Taiwan established its nationwide
TPR in 2004 so far 7000 health care facilities
have participated and the database has accumu-
lated more than 055 million AMEs[11] Infor-
mation generated from the TPR database can
improve patient safety at individual organiza-
tional or even national levels However despite
relentless efforts few substantial improvements
have been achieved in patient safety [15-17]
Since its introduction in Taiwan in 2006 the use
of RCA for AMEs has encountered some diffi-
culties 1) No structural and standardized
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 102
framework exists for investigation
cross-institution variability and interrater relia-
bility are often ignored 2) Conclusions are often
subjective and corrective recommendations are
less actionable relying on individual reviewersrsquo
professional backgrounds and their experiences
3) Much focus on event reconstruction and oper-
ator performance means that factors relating to
human behavior organizational culture and
system weakness are not comprehensively ad-
dressed [671718] Traditionally attempts to
improve patient safety in the health care industry
are largely reactive in nature identifying and
correcting errors in care processes [1920]
Causes of defects are not thoroughly understood
Proactive approaches must be taken to address
systematic problems within a complex system
[720] Research suggests that human error is a
causal factor in the occurrence of AMEs AME
investigation targets have moved from skill defi-
ciency toward decision-making attitudes super-
visory factors and even organizational climate
or culture HFACS methodology is based on the
Swiss cheese model that also emphasizes active
and latent failures [921] The study provides
some noteworthy findings First most AMEs as
expected involve active failures such as failure
to follow procedure accidental operation of
equipment inadequate real-time risk manage-
ment and inappropriate action These are all
sharp ends in classic RCA environment physi-
cal and mental factors are less prevalent This
proves that retrospectively determining addi-
tional causal factors is difficult when infor-
mation has not been collected during preliminary
investigation (Figure 1) Second team-
work-related problems particularly in relation to
communication and information relay are well
addressed This may be attributed to the dec-
ade-long institution-wide routine crew resource
management training in the respective research
hospital (Figure 2) Third the HFACS success-
fully reflects the importance of supervisory roles
in the occurrence of AMEs and this cannot be
overlooked (Figure 3) Fourth latent failures
especially in organizational climate or cultural
dimensions have been less frequently addressed
in incident reports a limitation of traditional
RCA However the HFACS review suggests
room for improvement in resource allocation and
policy modification within the hospital The
results of studies can make the organization
think about how to improve the patient safety
and management process from the perspective of
human factors such as improving the comfort of
the working environment and replacing and
equipment resources to prevent personnel from
affecting the medical quality and patient safety
due to the environment or equipment Need to
appropriate assessment of applicability and ade-
quate training of manpower is required The
management and control of risks should be fully
evaluate and grasp resource management and
leaders need to participate in and promote medi-
cal quality and patient safety activities to en-
hance its culture (Figure 4) No panacea exists
to ensure patient safety and improvement targets
originate largely from event investigation find-
ings Unfortunately factors identified from
AMEs are often self-explanatory with little value
for further action correction Reinforcement of
policy or processes redundant education or
repetitious training are formulaic overprescribed
RCA recommendations The use of HFACS in
this study proves that a structural prospective
AME investigation format can potentially help
with proactive patient safety management We
suggest developing an interview guideline for
the routine use of HFACS as a complement to
RCA in every AME investigation This study is a
retrospective study The underlying human fac-
tors can be under-estimated owing to the lack of
related information in the original RCA reports
CONCLUSION The HFACS review in this study enhances our
understanding of human factors in AMEs that
had previously been insufficiently scrutinized
Aside from active process and communication
errors the HFACS enables the prospective in-
vestigation of latent supervisory organizational
or systematic problems that cannot be addressed
through traditional RCA
REFERENCES 1 T Brennan L Leape N Laird et al
Incidence of adverse events and
negligence in hospitalized patients results
of the Harvard Medical Practice Study I N
Engl J Med 1991324370-376
2 Wang CH Shih CL Chen WJ et al
Epidemiology of medical adverse events
perspectives from a single institute in
Taiwan J Formos Med Assoc
2016115434-439
3 Vincent C Simon R Sutcliffe K et al
Errors Conference Executive Summary
Acad Emerg Med 200071180-1182
4 Taitz J Genn K Brooks V et al
System-wide learning from root cause
analysis A report from the New South
Wales Root Cause Analysis Review
Committee Qual Saf Health Care
2010191-5
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 103
5 Hutchinson A Young TA Cooper KL et
al Trends in healthcare incident reporting
and relationship to safety and quality data
in acute hospitals results from the
National Reporting and Learning System
Qual Saf Health Care 2009185-10
6 Mitchell RJ Williamson AM Molesworth
B et al A review of the use of human
factors classification frameworks that
identify causal factors for adverse events
in the hospital setting Ergonomics
2014571443-1472
7 Gurses AP Ozok AA Pronovost PJ Time
to accelerate integration of human factors
and ergonomics in patient safety BMJ
Qual Saf 201221347-351
8 Health and Safety Executive Introduction
to human factors
httpwwwhsegovukhumanfactorsintro
ductionhtm
9 Wiegmann DA Shappell SA A human
error approach to aviation accident
analysis The human factors analysis and
classification system Burlington VT
Ashgate Publishing Ltd 2003
10 Yu-Hsun Cheng Sheng-Hui Hung
Tung-Wen Ko et al An Analysis of the
Reliability and Validity of Human Factors
Analysis Classification System in Medical
Adverse Events Journal of Healthcare
Quality 20191370-76
11 Taiwan Joint Commission on Hospital
Accreditation Taiwan Patient-Safety
Reporting System Annual Report 2017
New Taipei City Taiwan
12 Taiwan Patient Safety Net
httpwwwpatientsafetymohwgovtwCo
ntentzMessagesslistaspxSiteID=1ampMm
mID=621273300317401756
13 Government of Western Australia
Department of Health
httpsww2healthwagovauArticlesS_T
Severity-assessment-codes
14 Farley DO Haviland A Champagne S et
al Adverse-event-reporting practices by
US hospitals results of a national survey
Qual Saf Health Care 200817416-423
15 Shojania KG Thomas EJ Trends in
adverse events over time why are we not
improving BMJ Qual Saf
201322273-277
16 Levitt P Challenging the systems approach
why adverse event rates are not improving
BMJ Qual Saf 2014231051-1052
17 Kellogg KM Hettinger Z Shah M et al
Our current approach to root cause
analysis is it contributing to our failure to
improve patient safety BMJ Qual Saf
201726381-387
18 Khorsandi M Skouras C Beatson K et al
Quality review of an adverse incident
reporting system and root cause analysis of
serious adverse surgical incidents in a
teaching hospital of Scotland Patient Saf
Surg 2012621
19 Diller T Helmrich G Dunning S et al
The Human Factors Analysis
Classification System (HFACS) Applied to
Health Care Am J Med Qual
201429181-190
20 Carayon P Xie A Kianfar S Human
factors and ergonomics as a patient safety
practice BMJ Qual Saf 201423196-205
21 Reason J Human Error New York
Cambridge University Press 1990
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 104
TABLE
Table 1 Incidences by Category (N=40)
CategorySAC SAC 4 SAC 3 SAC 2 SAC 1 total
Laboratory and ex-
amination events
4 10 2 0 16 (400)
Clinical care event 6 2 1 0 9 (225)
Medication event 5 0 2 0 7 (175)
Surgery-related event 1 1 2 0 4 (100)
Transfusion-related
event
1 1 0 0 2 (50)
Tube event 0 1 0 0 1 (25)
Public accident 0 0 1 0 1 (26)
Total 17 (425) 15 (375) 8 (200) 0 40 (100)
SAC 1113 Severity Assessment Code SAC
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 105
FIGURES
Figure 1 Active Failures (N=40)
16 (167)
66 (1000)
640 (150)
235 (57)
735 (200)
2435 (686)
2435 (686)
3540 (875)
438 (105)
438 (105)
738 (184)
1938 (500)
3138 (816)
3840 (950)
0 5 10 15 20 25 30 35 40
Commits WidespreadRoutine Violation
Performs Work-Around Violation
Ignored a CautionWarning
Failure to Prioritize Tasks Adequately
Wrong Choice of Action During an Operation
Inadequate Real‐Time Risk Assessment
Rushed or Delayed a Necessary Action
Breakdown in Visual Scan
Over-ControlledUnder-Controlled AircraftVehicleSystem
Unintended Operation of Equipment
Procedure Not Followed Correctly
Performance-Based Errors
Judgment and Decision Making Errors
Violations
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 106
Figure 2 Preconditions (Latent Failures or Conditions) (N=40)
14 (250)
24 (500)
48 (500)
11 (1000)
18 (125)
840 (200)
0 5 10 15 20 25 30 35 40
Seat and Restraint System Problems
Instrumentation amp Warning System Issues
Noise Interference
Environment
Physical Environment
Technological Environment
27 (286)
27 (286)
27 (286)
37 (129)
47 (511)
47 (571)
77 (1000)
24 (500)
44 (1000)
47 (571)
12 (500)
22 (1000)
27 (286)
740 (175)
0 5 10 15 20 25 30 35 40
Technical or Procedural Knowledge Not Retained After Training
InterferenceInterruption
Task OverUnder Saturation
Distraction
Negative Habit Transfer
Not Paying Attention
Complacency
Overconfidence
Physical IllnessInjury
Fatigue
Physical and Mental State
Physical Problem
State of Mind
Mental Awareness
211 (182)
311 (273)
311 (273)
411 (364)
811 (7227)
911 (818)
1140 (275)
0 5 10 15 20 25 30 35 40
Inadequate Task Delegation
TaskMission PlanningBriefingDebriefing Inadequate
Failure of CrewTeam Leadership
StandardProper Terminology Not Used
Critical Information Not Communicated
Failed to Effectively Communicate
Teamwork
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 107
Figure 3 Supervision (Direct Supervisory Chain of Command) (N=40)
Figure 4 Organization Influence (Upper-Level Management Command Level) (N=40)
114 (71)
114 (71)
214 (143)
314 (214)
1314 (929)
1440 (350)
511 (455)
511 (455)
711 (636)
1140 (275)
47 (571)
67 (857)
740 (175)
0 5 10 15 20 25 30 35 40
Selected Individual with Lack of Proficiency
Improper Role‐modeling
Failed to Provide Proper Training
Failed to IdentifyCorrect Risky or Unsafe Practices
SupervisoryCommand Oversight Inadequate
Performed Inadequate Risk Assessment ‐Formal
Selected Individual with Lack of Current or Limited Experience
Authorized Unnecessary Hazard
Allowing Unwritten Policies to Become Standard
Failure to Enforce Existing Rules
Supervisory Violations
Planned Inappropriate Operations
Inadequate Supervision
12 (500)
12 (500)
240 (50)
110 (100)
510 (500)
1040 (250)
11 (1000)
140 (25)
18 (125)
18 (125)
38 (35)
48 (500)
840 (200)
0 5 10 15 20 25 30 35 40
Organizational Over-confidence or Under-confidence in Equipment
Organizational Culture (attitude actions) Allows for Unsafe TaskMission
Purchasing or Providing Poorly Designed or Unsuitable Equipment
Organizational ProgramPolicy Risks not Adequately Assessed
Failure to Provide Adequate Manning Staffing Resources
Failure to remove inadequate worn-out equipment in timely manner
Inadequate infrastructure
Command and control resources are deficient
Failure to provide adequate operational information resources
Resource Problems
Personnel Selection amp Staffing
Policy and Process Issues
ClimateCulture Influences
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 108
Supplement Table 1- HFACS Content of Human Factor Analysis Classifi-
cation System [9] Tier main level sub-item nano code
Tier 1 Unsafe Acts
Perfor-
mance-Based
Errors
Unintended operation of equipment
Checklist not followed correctly
Procedure not followed correctly
Over-controlledunder-controlled aircraftvehiclesystem
Breakdown in visual scan
Rushed or delayed a necessary action
Judgment amp De-
cision-Making
Errors
Inadequate real‐time risk assessment
Failure to prioritize tasks adequately
Ignored a cautionwarning
Wrong choice of action during an operation
Violations
Performs work-around violation
Commits widespreadroutine violation
Extreme violation-lack of discipline
Tier 2 Preconditions
Environment
Physical environment
Environmental conditions affecting vision
Vibration effects vision or balance
Heatcold stress impairs performance
External force of object impeded an individualrsquos
movement
Lights of other vehiclevesselaircraft affected vision
Noise interference
Technological environment
Seat and restraint system problems
Instrumentation amp warning system issues
Visibility restrictions (not weather related)
Controls and switches are inadequate
Automated system creates unsafe situation
Workspace incompatible with operation
Personal equipment interference
Communication equipment inadequate
Physical and
Mental State
Physical problem
Substance effects (alcohol supplements medications
drugs)
Loss of consciousness (sudden or prolonged onset)
Physical illnessinjury
Fatigue
Inadequate adaptation to darkness
Dehydration
Body sizemovement limitations
Physical strength amp coordination (inappropriate for
task demands)
Nutritiondiet
State of mind
Psychological problem
Life stressors
Emotional state
Personality style
Overconfidence
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 109
Pressing
Complacency
Motivation
Motivational exhaustion (burnout)
Sensory misperception
Motion illusion-kinesthetic
Turning illusionbalance-vestibular
Visual illusion
Misperception of changing environment
Misinterpreted misread instrument
Misinterpretation of auditorysound cues
Spatial disorientation
Temporaltime distortion
Mental awareness
Not paying attention
Fixation
Task overunder saturation
Confusion
Negative habit transfer
Distraction
Geographically lost
Interferenceinterruption
Technical or procedural knowledge not retained after
training
Inaccurate expectation
Teamwork
Failure of crewteam leadership
Inadequate task delegation
Rankposition intimidation
Lack of assertiveness
Critical information not communicated
Standardproper terminology not used
Failed to effectively communicate
Taskmission planningbriefingdebriefing inadequate
Tier 3 Supervision
Supervisory Vio-
lations
Failure to enforce existing rules
Allowing unwritten policies to become standard
Directed individual to violate existing regulations
Authorized unqualified individuals for task
Planned Inappro-
priate Operations
Directed task beyond personnel capabilities
Inappropriate team composition
Selected individual with lack of current or limited experience
Performed inadequate risk assessment ‐formal
Authorized unnecessary hazard
Inadequate Su-
pervision
Supervisorycommand oversight inadequate
Improper role‐modeling
Failed to provide proper training
Failed to provide appropriate policyguidance
Personality conflict with supervisor
Lack of supervisory responses to critical information
Failed to identifycorrect risky or unsafe practices
Selected individual with lack of proficiency
Tier 4 Organizational
Influences
Resource Prob-
lems
Command and control resources are deficient
Inadequate infrastructure
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 110
Failure to remove inadequate worn-out equipment in timely
manner
Failure to provide adequate operational information resources
Fail to provide adequate funding
Personnel Selec-
tion amp Staffing
Personnel recruiting amp selection policies are inadequate
Failure to provide adequate manning staffing resources
Policy amp Process
Issues
Pace of ops-tempoworkload
Organizational programpolicy risks not adequately assessed
Provided inadequate procedural guidance or publications
Organizational (formal) training is inadequate or unavailable
Flawed doctrinephilosophy
Inadequate program management
Purchasing or providing poorly designed or unsuitable equip-
ment
ClimateCulture
Influences
Organizational culture (attitude actions) allows for unsafe
taskmission
Organizational over-confidence or under-confidence in equip-
ment
Unit missionaircraftvehicleequipment change or unit deacti-
vation
Organizational structure is unclear or inadequate
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 111
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
以 HFACS重新檢視根本原因分析案例挖掘造成醫療不良
事件之人為因素
鄭伃洵 1洪聖惠 12柯彤文 3王拔群 14
中文摘要
背景醫療不良事件(AMEs)的管理是促進病人安全的基石根本原因分析
(RCA)是探討重大病人安全不良事件問題但是由於無法解釋更廣泛的因素而受
到限制本研究使用人為因素分類與分析工具(HFACS)回溯審視醫療不良事件
以了解影響醫療不良事件的人為因素及各層面中錯誤原因之分佈或系統性問題
方法本研究回溯 2012-2016年間有做過根本原因分析之醫療不良事件以連續
性取樣方式(continuous sampling)收集 40例醫療不良事件以人為因素分類與分
析工具(HFACS)去系統性的挖掘每件案例發生錯誤之原因結果在行為層面中
分析結果主要為基礎技能錯誤(95)判斷和決策錯誤(875)其中在基礎技能
錯誤當中以未依程序作業執行(816)及未如預期設備操作(50)佔多數判斷和
決策錯誤中以現場風險評估不確實(686)及採取錯的步驟行為(686)佔多數
而在先決條件層面中以團隊合作(275)為主要因素包含溝通不良(818)及重
要訊息未以正確的方式即時傳達(727)佔多數在監督層面當中以監督不周
(929)或監督不妥當(929)為主要因素在組織政策和流程方面(50)以組織
系統的政策風險未充分評估(35)為主要因素結論本研究進一步了解醫療不
良事件在過去使用根本原因分析未探討到的人為因素反映出潛在的監督組織
行為或系統性的問題促進病人安全預防錯誤再發生
關鍵字病人安全醫療不良事件根本原因分析人為因素
1國泰醫療財團法人國泰綜合醫院 品質管理部
2國立臺灣大學健康政策與管理研究所
3振興醫療財團法人振興醫院 醫療品質管理中心
4輔仁大學醫學院
通訊作者王拔群 電子信箱 drtonyseednettw
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin 112
Submitted January 20 2020
Final version accepted April13
2020
Case Report
Juvenile Caruncular Atypical Lymphoid
Proliferation ndash A Rare Case Report
Cite as Hua-Wei Shih Yu-Chi Lin
Juvenile Caruncular Atypical
Lymphoid Proliferation ndash A Rare
Case Report Fu-Jen Journal of
Medicine 3(3) 112-119 2020
DOI
103966181020932020091803003
Hua-Wei Shih1 Yu-Chi Lin
1
1Department of Ophthalmology Shin Kong Wu Ho-Su Memorial Hos-
pital Taipei City Taiwan
Corresponding author E-mail address
yuchi067gmailcom (Yu-Chi Lin)
ABSTRACT
Lesions of the caruncle are very rare Most caruncular lesions are benign though there were still few reported malignant lesions Ocular adnexal lymphoproliferative disease (OALD) one of the differential diagnosis of caruncular lesion is seldom seen in young pa-tient In this article we report a 16-year-old boy with recurrent caruncular atypical lym-phoid proliferation We discuss the epidemiology clinical features images histomorpholo-gy and treatment between ocular adnexal lymphomas (OAL) and reactive lymphoid hyper-plasia (RLH)
Keywords caruncular lesion ocular adnexal lymphoproliferative disease ocular adnexal lymphoma
reactive lymphoid hyperplasia atypical lymphoid proliferation
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
113
INTRODUCTION Lesions of the caruncle are very rare Differen-
tial diagnosis includes nevus myeloproliferative
disorders tumors inflammation infection cysts
vascular lesions and fibrous Biopsy is essential
for diagnosis Levy J et al reported ocular ad-
nexal lymphoproliferative disease (OALD) was
relatively uncommon diagnosis among caruncu-
lar lesions [1]
OALD was seldom described in Asian popula-
tion especially for young age C-Y Cheng re-
ported age-standardized incidence of ocular
adnexal lymphomas (OAL) in Taiwan from 1979
to 1996 was below 07 per million per year and
mean age was 531 years old [2] In 2015 five
Taiwanese cases of OAL whose age ranging
from 45 to 64 were presented [3] However
there were few cases of conjunctival OAL or
RLH in Chinese pediatric patient
Here we present a case of 16-year-old boy with a
caruncular mass at his left eye with recurrence
one month after excision We describe his clini-
cal symptoms photographs pathological results
management and follow-up clinical course in
this report
CASE REPORT A 16-year-old healthy boy presented a mass
lesion at his left eye caruncle accompanied with
the symptom of tearing for one month (Figure 1)
He had no ocular pain no itchiness no blurred
vision no night sweating no fever and no body
weight loss The patient denied systemic diseas-
es and histories of surgery His bilateral best
corrected visual acuity (BCVA) were 66 and
intraocular pressure (IOP) were both within
normal range There were no remarkable find-
ings for his cornea lens fundus and physical
examination Excision was performed and the
mass was soft with fluid inside therefore con-
junctival pyogenic cyst was our initial diagnosis
However one month after the excision a pro-
truding mass recurred at the patientrsquos nasal can-
thus of left eye (Figure 2) There were some
differences compared to previous condition At
the first time the soft mass was contained in a
well-defined cyst wall which more favored py-
ogenic granulation However after short period
of recurrence solid consistency and unclear
margin were found which favored malignancy
Besides the mass partially involved beyond the
gray line of nasal part lower eyelid whereas last
time the cyst mainly extended from conjunctiva
of caruncle The second excisional biopsy was
performed Pathologic examination demonstrat-
ed abundant atypical lymphoid proliferation
(Figure 3A 3B) Immunohistochemical studies
showed that the lymphoid aggregation was
composed predominantly of CD20-positive cells
(Figure 3C) focal positive staining of CD3
(Figure 3D) CD5 CD23 CD10 and negative
staining of cyclin-D1 Unfortunately the cellular
morphology was difficult to be evaluated due to
marked crushing artifact Thus malignant lym-
phoma cannot be excluded totally
Orbital computed tomography (CT) showed a
lesion of soft tissue density at medial canthus of
left orbit without obvious nasolacrimal duct or
bony invasion (Figure 4A) Magnetic resonance
imaging (MRI) with contrast showed strong
enhancement at left medial canthus region (Fig-
ure 4B) There was no remarkable finding in the
systemic workup including complete blood
count and differential count biochemical pro-
files and 18F-fluoro-2-deoxyglucose positron
emission tomographycomputed tomography
(18F-FDG PETCT) indicating no evidence of
systemic involvement
After the second excision we preferred con-
servative management for him due to the uncer-
tainty of malignancy and to avoid side effects
from aggressive treatment No sign of recurrence
was noted after 10 months of observation The
follow-up photo was taken at three months after
the second operation (Figure 5)
DISCUSSION Ocular adnexal lymphoproliferative disease
(OALD) consists of the spectrum of lymphoid
disease affecting the tissues surrounding the eye
including ocular adnexal lymphomas (OAL) and
lymphoid hyperplasia (LH) [4] The conjunctiva
is an important location for extranodal lympho-
ma development which comprises 25 of OAL
[5]
OAL can be grouped into two categories based
on their appearance of cells under the micro-
scope low-grade and high-grade [6] Extranodal
marginal zone lymphoma of mucosa-associated
lymphoid tissue (EMZLMALT) is the most
common subtype of OAL followed by follicular
lymphoma [7-9] Both of the above are
low-grade lymphomas
LH can be further divided by histopathology into
reactive lymphoid hyperplasia (RLH) and atypi-
cal lymphoid hyperplasia (ALH) RLH has to-
tally benign morphology and immunophenotype
whereas ALH has borderline lesions between
RLH and lymphoma [10] OAL and LH are
mostly seen in patients with age between 50-70
years old There are rare cases in pediatric group
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
114
[71011] In the C-Y Chengrsquos statistical report of
OAL in Taiwan only 8 patients were younger
than 15 years old among the 101 cases of ocular
lymphoma [2] According to an US study inci-
dence rates of OAL were analyzed in different
age groups the group of age over 50 had the
highest incidence rate of 574 per million per-
son-years while the 0-19 age group had the
lowest incidence rate of 009 per million per-
son-years [12] The incidence of LH was even
less than OAL [13]
Patients with OALD may be asymptomatic or
with symptoms of proptosis eyelid swelling a
palpable painless mass or conjunctival salmon
patch Diplopia visual loss pain or inflamma-
tion occurred less frequently implying more
aggressive features [714]
Orbital LH is not distinguishable from low-grade
lymphoma radiologically They both typically
present a round or lobulated mass that diffusely
moderately enhances with contrast and usually
shows homogenous hypointense or isointense to
muscle barely invasion to bone or nervous sys-
tem [10] Atypical appearances including inho-
mogeneous calcification or bony changes may
be seen in high-grade lymphoma case reports
such as ocular adnexal diffuse large B-cell lym-
phoma (DLBCL) which is one of the more ag-
gressive type of OAL [7] Whole body PET is
used for not only the evaluation of systemic
involvement but also the standard for staging
lymphoma Our patientrsquos image studies revealed
neither obvious local invasion nor systemic ma-
lignancy indicating high-grade lymphoma was
less likely Low-grade lymphoma and benign
reactive lymphoid hyperplasia were still under
consideration
Histomorphology analysis and immunohisto-
chemistry (IHC) are essential for diagnosis
Flow cytometry and polymerase chain reaction
(PCR) technique are also applied to help differ-
entiate from RLH and OAL [1016] Our case
had immunohistochemical profile of positivity
for CD20 predominantly positivity focally for
CD3 CD5 CD10 CD23 and negativity for cy-
clin-D1 BCL-6 staining was not performed in
our casersquos biopsy Thus according to the IHC
report RLH ALH and follicular lymphoma are
probable diagnosis of our patient
Radiation therapy is the standard treatment for
low-grade OAL that is classified as T1N0M0 or
T2N0M0 according to the AJCC criteria [15]
İncesoy-Ouml zdemir S et al reported a 10-year-old
boy diagnosed of MALT lymphoma who was
treated with local radiotherapy (36 Gy) and
there were no local or systemic recurrences dur-
ing his nearly four-year follow-up [17] Another
case report represented a 21-year-old man of
conjunctival follicular lymphoma treated with
surgical excision only showing no evidence of
recurrence after 8 months follow-up [18] Other
treatment options for pediatric and juvenile OAL
were performed in some case reports including
intravenous rituximab intralesional interfer-
on-α-2b topical interferon a6 systemic doxycy-
cline surgical excision and postoperative local
cryotherapy [15]
Treatment for young conjunctival RLH was less
discussed in the past In a case series article
three children (9 13 14 years old respectively)
of RLH received surgical resection without fur-
ther postoperative management and no signs of
recurrence were noted during follow-up [19]
Short-term topical and oral corticosteroids after
surgical excision were prescribed in two pediat-
ric RLH patients for their small residual mass
However poor response in both cases was nota-
ble [20]
Our patient declined to receive radiotherapy or
any further postoperative treatment mainly due
to his concerning of possible side effects (such
as dry eye and cataract)
CONCLUSION We present a rare case of caruncle mass in this
report OALD is one of the relatively uncommon
diagnosis among caruncular lesions OALD
includes benign RLH and malignant OAL
which are both mainly seen in elderly patients
even rarer in pediatric or juvenile group
The standard treatment for low-grade OAL and
RLH in young patents are still debatable How-
ever long-term follow-up is suggested for both
OAL and RLH patients Though RLH has a be-
nign and self-limited course risk of malignant
transformation is possible
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the caruncle a description of 42 cases and
a review of the literature Eye
200923(5)1004-1018
2 C-Y Cheng and W-M Hsu Incidence of
eye cancer in Taiwan an 18-year review
Eye 200418152-158
3 Chui-Lien Tsen Muh-Chiou Lin
Youn-Shen Bee et al Ocular adnexal
lymphoma Five case reports and a
literature review Taiwan Journal of
Ophthalmology 20155(2)99-102
4 Liesegang TJ Ocular adnexal
lymphoproliferative lesions Mayo Clin
Proc 199368(10)1003-1010
5 Kirkegaard MM Coupland SE Prause JU
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
115
et al Malignant lymphoma of the
conjunctiva Surv Ophthalmol
201560(5)444-458
6 Stacy RC Jakobiec FA Schoenfield L et
al Unifocal and multifocal reactive
lymphoid hyperplasia vs follicular
lymphoma of the ocular adnexa Am J
Ophthalmol 2010150(3)412-426
7 Sullivan TJ Ocular Adnexal
Lymphoproliferative Disease In Guthoff
RF Katowitz JA eds Oculoplastics and
Orbit Berlin Heidelberg Springer
20101-19
8 White Valerie A Understanding and
Classification of Ocular Lymphomas
Ocular Oncology and Pathology
20195379-386
9 Stefanovic A Lossos IS Extranodal
marginal zone lymphoma of the ocular
adnexa Blood 2009114(3)501-510
10 Andrew NH Coupland SE Pirbhai A et al
Lymphoid hyperplasia of the orbit and
ocular adnexa A clinical pathologic review
Surv Ophthalmol 201661(6)778-790
11 Ferry JA1 Fung CY Zukerberg L et al
Lymphoma of the ocular adnexa A study
of 353 cases Am J Surg Pathol
200731(2)170-184
12 WM Hassan MS Bakry HM Hassan et al
Incidence of orbital conjunctival and
lacrimal gland malignant tumors in USA
from Surveillance Epidemiology and End
Results 1973-2009 Int J Ophthalmol
20169(12)1808-1813
13 Ajay A Rao John H Naheedy James Y-Y
Chen et al A Clinical Update and
Radiologic Review of Pediatric Orbital
and Ocular Tumors Journal of Oncology
2013(9)975908
14 Sullivan TJ Whitehead K Williamson R
et al Lymphoproliferative disease of the
ocular adnexa a clinical and pathologic
study with statistical analysis of 69
patients Ophthal Plast Reconstr Surg
200521177-188
15 Tanenbaum RE Galor A Dubovy SR et al
Classification diagnosis and management
of conjunctival lymphoma Eye Vis (Lond)
2019622
16 Olga Klavdianou Georgios Kondylis
Vasileios Georgopoulos et al Bilateral
benign reactive lymphoid hyperplasia of
the conjunctiva a case treated with oral
doxycycline and review of the literature
Eye Vis (Lond) 2019626
17 İncesoy-Ouml zdemir S Yuumlksek N Bozkurt C
et al A rare type of cancer in children
extranodal marginal zone B-cell (MALT)
lymphoma of the ocular adnexa Turk J
Pediatr 201456(3)295-298
18 Lynn J Poole Perry Frederick A Jakobiec
Peter A D Rubin Conjunctival Pediatric
Follicular Lymphoma Arch Ophthalmol
2012130(7)941-943
19 Abdullah Al-Mujaini Upender Wali
Anuradha Ganesh1 et al Ocular Adnexal
Reactive Lymphoid Hyperplasia in
Children Middle East Afr J Ophthalmol
201219(4)406-409
20 McLeod SD Edward DP Benign
lymphoid hyperplasia of the conjunctiva in
children Arch Ophthalmol
1999117(6)832-835
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
116
FIGURES
Figure 1 Slit lamp image of a mass lesion at the patientrsquos left eye caruncle for one month
Figure 2 One month after the first excision a protruding mass recurred at the patientrsquos nasal canthus
of left eye It partially involved beyond the gray line of nasal part lower eyelid
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
117
Figure 3 Histomorphology analysis and immunohistochemistry study of the caruncular lesion Abun-
dant atypical lymphoid proliferation presented in low-power photomicrograph (A) and
high-power photomicrograph (B) under hematoxylin-eosin staining The lymphoid aggrega-
tion was composed predominantly of CD20-positive cells (C) and focal positive staining of
CD3 (D)
Figure 4 Non-contrast orbital computed tomography showed a lesion of soft tissue density at medial
canthus of left orbit without obvious nasolacrimal duct or bony invasion (A) Magnetic reso-
nance imaging with contrast showed strong enhancement at left medial canthus region (B)
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
118
Figure 5 The follow-up photo were taken at three months after the second excision showing no signs
of recurrence
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
119
Juvenile Caruncular Atypical Lymphoid Proliferation ndash A Rare Case Report
罕見病例報告mdash青少年之淚阜非典型淋巴增生
施驊瑋 1林友祺 1
中文摘要
淚阜病灶相當罕見大部分為良性病灶眼睛及附屬結構淋巴增生疾病為其
鑑別診斷之一非常少見於年輕人或兒童我們報告一位 16歲的健康男性因
左眼淚阜無痛性腫塊接受切除手術卻於術後一個月復發執行第二次切除手術
後門診追蹤十個月未再復發此案例表現了部分良性與部分惡性腫瘤的特徵
我們針對反應性淋巴增生眼睛及附屬結構淋巴癌兩個疾病做討論及文獻回顧
關鍵字淚阜病灶眼睛及附屬結構淋巴增生疾病眼睛及附屬結構淋巴癌反
應性淋巴增生非典型淋巴增生
1 新光吳火獅紀念醫院眼科
通訊作者林友祺 電子信箱 yuchi067gmailcom
Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh 120
Submitted March 26 2020
Final version accepted April 16
2020
Case Report
Hyperacute intramembranous hemor-
rhage after burr hole craniostomy for
chronic subdural hematoma
Cite as Meng-Chi Lin Jui-Ming
Sun Yu-Hao Chen Cheng-Ta
Hsieh
Hyperacute intramembranous
hemorrhage after burr hole crani-
ostomy for chronic subdural he-
matoma Fu-Jen Journal of Medi-
cine 3(4) 120-125 2020
DOI
103966181020932020091803004
Meng-Chi Lin1 Jui-Ming Sun23 Yu-Hao Chen24 Cheng-Ta
Hsieh567
1Department of Surgery Zuoying Branch Kaohsiung Armed Forces
General Hospital Kaohsiung 813 Taiwan 2Section of Neurosurgery Department of Surgery Chia-Yi Christian
Hospital Chia-Yi City 600 Taiwan 3Department of Biotechnology Asia University Taichung City 41354
Taiwan 4Chung-Jen Junior College of Nursing Health Sciences and Manage-
ment Chia-Yi Country 62241 Taiwan 5Division of Neurosurgery Department of Surgery Sijhih Cathay Gen-
eral Hospital New Taipei City 22174 Taiwan 6Department of Medicine School of Medicine Fu Jen Catholic Univer-
sity New Taipei City 24205 Taiwan 7Department of Neurological Surgery Tri-Service General Hospital
National Defense Medical Center Taipei 114 Taiwan
Corresponding author E-mail address
nogormail2000comtw (Cheng-Ta Hsieh)
ABSTRACT
Burr hole craniostomy with closed-system drainage is an effective and common neurosurgical procedure to manage chronic subdural hematoma Postoperative hem-orrhage a well-known but infrequent complication may result in increased neurolog-ical deficits However hyperacute intramembranous hemorrhage within the inner and outer membrane of hematoma after burr hole craniostomy with irrigation and closed-system drainage has not been described previously Herein we report a case of postoperative spontaneous hyperacute intramembranous hemorrhage after burr hole craniostomy with closed-system drainage to manage a chronic subdural hematoma we subsequently discuss the possible pathophysiological mechanisms and review the relevant literature
Keywords Chronic subdural hematoma acute subdural hematoma bleeding burr hole craniostomy
drainage
Fu-J
Meng
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of Medicine V
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Vol 3 No 4 2
Acute intram
Yu-Hao Chen
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outer and ievidence suggwith or wite and widely ut and that it ] Recurrence r this surgerywever the hyng after burr ely been discucase of a pa
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gure 3) No aface was obseealed an organn of fibroblasne Postoperaogical deficits
ISCUSSIO61-year-old won without regd been takingning Ganodermrs She was tment when shurological exasgow Coma S
muscle strengs was 45 on
ale Her laborh the normal rnoted Brain
n revealed Ch a marked m
ently she receniostomy withinage ring surgery mthe subdural sn of the duramatoma The arile saline throsed drainage swever this inm the subduraealed a hyperdural space fniostomy siteniotomy withthe hematom
morrhage was d inner membgure 3) No aface was obseealed an organn of fibroblasne Postoperaogical deficits
EFERENCRohde VComplicatiand closedsubdural analysis of
active bleedinerved Histolonized hematots and capilla
ative recoverywas gradual a
ON oman had a hi
gular medicatig nutritional ma lucidum referred to ohe became proxamination rScale ratings wgth score in th
the Medical ratory examinranges with nn computed
CSDH in the midline shift (ived one righth irrigation a
motor oilndashlikespace was uncal and outer marea was irrigaough the subdusystem was plcreased the rel space An emracute hemorrfrom the frone (Figure 2B
membranectma was perfo
only observebrane of theactive bleedinerved Histolonized hematots and capilla
ative recoverywas gradual a
CES V Graf Gons of burr-
d-system draihematomas
f 376 patient
ng from the ogical examinoma with prolaries in the m
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history of hypeion treatmentsupplements for more tha
our emergencyogressively drrevealed thatwere E1M5V2he left side ex
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(Figure 1) St parietal burrand closed-sy
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Vol 3 No 4 2
Acute intram
Yu-Hao Chen
vealing a layer
displaying a m
quent CT scan
em drainage (
rhage in the ri
2020
membranous
Cheng-Ta Hs
red type of CS
midline shift
ns (A) Bone w
(white arrow)
ight frontal re
hemorrhage
ieh
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window view
and (B) Soft
gion (white ar
rrow) in the rig
showed the b
tissue windo
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ow showed hy
123
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Fu-J
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g-Chi Lin Ju
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Vol 3 No 4 2
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Yu-Hao Chen
o revealing ac
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the previous b
2020
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cute intramem
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124
mem-
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Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh
125
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
慢性硬腦膜下出血進行鑽顱引流手術造成超急性夾膜內出
血
林孟楫 1孫瑞明 23陳昱豪 24謝政達 567
中文摘要
鑽顱併封閉系統引流手術是治療慢性硬腦膜下出血患者一種有效且常見的
神經外科手術方式術後出血可能導致神經功能缺損惡化是眾所周知但不常見
的併發症之一然而至今仍未有鑽孔併封閉系統引流造成原本慢性硬腦膜血
塊內膜和外膜間急性夾膜間出血案例在這裡我們報告一例慢性硬腦膜下出
血病患者接受鑽顱併封閉系統引流手術治療造成術後急性夾膜間出血我們在
本文中討論可能的致病機制並回顧相關文獻
關鍵字慢性硬腦膜下出血急性硬腦膜下出血出血鑽顱術引流
1國軍高雄總醫院左營分院 外科部
2崇仁醫護管理專科學校
3亞洲大學 生物科技學系
4戴德森醫療財團法人嘉義基督教醫院 外科部 神經外科
5汐止國泰綜合醫院 神經外科
6輔仁大學 醫學系
7 國防醫學院 三軍總醫院 神經外科
通訊作者謝政達 電子信箱 nogormail2000comtw
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
126
Submitted January 21 2020
Final version accepted July 08
2020
Case Report
Hamartoma of the breast A case report
Cite as Hsuan-An Chen
Cheng-Yu Lo Shih-Hung Huang
Chin-Lung Lin
Hamartoma of the breast A case
report Fu-Jen Journal of Medicine
3(5) 126-130 2020
DOI
103966181020932020091803005
Hsuan-An Chen1 Cheng-Yu Lo
3 Shih-Hung Huang
3 Chin-Lung
Lin2
1Department of Surgery Cathay General Hospital Taipei Taiwan
2Department of General Surgery Cathay General Hospital Taipei Tai-
wan
3Department of Pathology Cathay General Hospital Taipei Taiwan
Corresponding author E-mail address
lungyungmailcom (Chin-Lung Lin)
ABSTRACT
Breast hamartoma is an uncommon benign tumor rarely associated with malignancy An
excision and histological examination is necessary for the differential diagnosis We report
a case of a 49-year-old female patient presenting with a lump in the right breast Ultrasound
examination which demonstrated a 4411 cm hypoechoic lesion with lipoma Partial mas-
tectomy was arranged and the diagnosis of a hamartoma was confirmed by the histological
examination
Keywords Breast tumor Hamartoma Ultrasound
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
127
INTRODUCTION The hamartoma is a benign tumor-like lesion
that can affect various organs of the body in-
cluding lungs kidneys skin and more rarely the
breast In 1981 the hamartomas were recognized
in the WHO classification[1] They are defined
as well-demarcated mass of mammary ducts and
lobules containing varying amounts of fibrous
and adipose tissue and producing a distinctive
mammographic image
CASE REPORT A 49 year-old female had past history of left
breast mastitis with abscess status post partial
mastectomy This time she presented to our out
patient clinic for breast examination Physical
examination revealed a painless palpable mova-
ble and painless lump at upper outer quadrant of
right breast The risk of breast cancer was not
noted and the patient did not have any family
history of breast cancer The patient also denied
any trauma history before Ultrasound examina-
tion was arranged which demonstrated a 4411
cm hypoechoic lesion with lipoma at 3 oclock 2
cm from nipple of right breast and multiple hy-
poechoic nodules of various size in both breasts
and there was no suspicious axillary lymph
nodes noted (Figure1) Surgical treatment was
arranged partial mastectomy of right breast
harmartoma was successfully performed A 32 x
31 x 21 cm tumor was completely excised
Grossly examination showed a gray to yellow
and firm to fatty The diagnosis of a hamartoma
was confirmed by the histological examination
Microscopically sections of the breast lesion
show mammary hamartoma composed of ducts
lobules with interlobular fibrous tissue and adi-
pose tissue Fibrocystic change apocrine meta-
plastic ducts and scattered foci of adenosis are
noted The overall lobulocentric architecture and
the 2-cell pattern of the epithelium are preserved
columnar cell change and focal microcalcifica-
tion are present (Figure2) Based on submitted
biopsy specimen in-situ or invasive tumor cells
are not identified
DISCUSSION Hamartoma of the breast is a benign tumor like
nodule it was also known as fibroadenolipoma
lipofibroadenoma or adenolipoma based on its
predominant components It was composed of
varying amounts of glandular adipose and fi-
brous tissue[2] Hamartomas were first described
in 1971 by Arrigoni et al in a study of 10 patients
which breast tumors clinically and grossly re-
sembled fibroadenomas[3]
A higher predominance of tumors exists in fe-
males compared with males Hamartomas are
slowly-growing lesions with the diameter rang-
ing from 2 cm to 5 cm sometimes hamartomas
can reach giant diameter [4]
The clinical diagnosis of hamartoma is based on
the findings from mammography sonography
and histology examinations The hamartomas are
usually incidentally diagnosed by the women
older than 40 year-old starting mammography
screening
On physicial examination harmatomas are usu-
ally occult painless they may be as large mo-
bile soft to firm masses[5] Ultrasound showed
well capsulated mass with echogenic rim and
internal heterogeneity Mammography exam
showed well-circumscribed round to oval
masses containing fat and soft tissue densities
with a thin radiopaque pseudocapsule The
pseudocapsule results from displacement of
breast parenchyma by the tumor [56] In Pa-
thology finding microglandular adenosis is pre-
sent in fibroadipose stroma surrounded by a thin
fibrous capsule It composed of a combination of
epithelial and stromal elements usually with
normal ducts or lobules although variations of
normal tissue may also be seen Fibroadenoli-
poma myoid hamartoma and chondrolipoma are
histological variations of hamartomas depend-
ing on the proportion of normal breast tissue
elements[7]
Malignancy associated with hamartomas are
very rare[8] However it has been reported
hamartomas develop into carcinoma Malignant
transformation can occur as a result of cellular
atypia in the epithelial component of the mass[9]
Surgical removal is the curative method for
breast hamartomas[10] Diagnostic material such
as mammography ultrasonography or core nee-
dle biopsy may not give the definitive diagnosis
Therefore surgical excision and histological
examination is necessary for differential diagno-
sis[111213]
Although it is rare hamartoma can be seen along
with malignancy as it is formed from similar
components of breast tissue Therefore careful
diagnosis and appropriate management including
surgery are required
REFERENCES 1 World Health Organization (1981)
Histological typing of breast tumors In
International histological classification of
tumors 1981 2nd ed
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
128
2 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11435ndash449
2006
3 ArrigoniMG DockertyMB JuddES
The identificationand treatment of
mammary hamartoma Surg Gynecol
Obstet1971 133 577-82
4 Sanal HT Ersoz N Altinel O Unal E Can
C Giant hamartoma of the breast Breast J
2006 12 84-85
5 Feder JM de Paredes ES Hogge JP
Wilken JJ Unusual breast lesions
radiologic-pathologic correlation
Radiographics 1999 19S11ndashS26
6 Murat A Ozdemir H Yildirim H Poyraz
AK Ozercan R Hamartoma of the breast
Australas Radiol 200751 Spec NoB37ndash
9
7 Fisher CJ Hanby AM Robinson L Millis
RR Mammary hamartoma-a review of 35
cases Histopathology 1992 20 99-106
8 Choi N Ko ES Invasive ductal carcinoma
in a mammary hamartoma case report and
review of the literature Korean J Radiol
2010 Nov-Dec11(6)687-91
9 Lee EH Wylie EJ Bourke AG Bastiaan
De Boer W Invasive ductal carcinoma
arising in a breast hamartoma two case
reports and a review of the literature Clin
Radiol 2003 58 80-3
10 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11 435 ‑449
2006
11 Coyne J Hobbs FM Boggis C Harland R
Lobular carcinoma in a mammary
hamartoma J Clin Pathol 199245936ndash
937
12 G M K Tse B K B Law T K F Ma A B W
Chan Hamartoma of the breast a
clinicopathological review J Clin Pathol
200255951ndash954
13 RAAmir SSheikh BreasthamartomaA
report of 14cases of an under-recognized
and under-reported entity International
Journal of Surgery Case Reports
22(2016)1ndash4
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
129
FIGURES
Figure 1 Ultrasound shows a 4411 cm hypoechoic lesion with lipoma at 3 oclock 2 cm from nipple
of right breast
Figure 2 Photomicrograph shows mammary hamartoma composed of ducts lobules with interlobular
fibrous tissue and adipose tissue
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
130
Hamartoma of the breast A case report
乳房錯構瘤罕見個案報告
陳宣安 1羅承裕 3黃世鴻 3林錦龍 2
中文摘要
乳房錯構瘤是一種罕見之乳房良性腫瘤切除手術及病理化驗來做鑑別診斷
我們報告一位 49歲女性以可觸摸到無痛性右側乳房腫塊為臨床表徵超音波
看到一個邊緣清楚低迴音的腫塊病患接受手術切除病灶病理診斷證實為乳
房錯構瘤
關鍵字乳房腫瘤錯構瘤超音波攝影
1國泰綜合醫院外科部
2國泰綜合醫院一般外科
3國泰綜合醫院病理科
通訊作者林錦龍 電子信箱 lungyungmailcom
Fu-Jen Journal of Medicine
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Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang
99
Submitted October 11 2019
Final version accepted February
02 2020
Original Research Article
Human Factors Underlying Adverse
Medical Events Revisit Root Cause Anal-
ysis Cases Using the HFACS
Cite as Yu-Hsun Cheng
Sheng-Hui Hung Tung-Wen Ko
Pa-Chun Wang
Human Factors Underlying Ad-
verse Medical Events Revisit
Root Cause Analysis Cases Using
the HFACS Fu-Jen Journal of
Medicine 3(2) 99-111 2020
DOI
103966181020932020091803002
Yu-Hsun Cheng1 Sheng-Hui Hung
12 Tung-Wen Ko
3 Pa-Chun
Wang14
1Department of Quality Management Cathay General Hospital Taipei
Taiwan
2Institute of Health Policy and Management National Taiwan Universi-
ty Taipei Taiwan
3Center for Healthcare Quality Management Cheng Hsin General Hos-
pital Taipei Taiwan
4Fu Jen Catholic University School of Medicine New Taipei City Tai-
wan
Corresponding author E-mail address
drtonyseednettw (Pa-Chun Wang)
ABSTRACT Background Appropriate management of adverse medical events (AMEs) is the corner-
stone of patient safety Root cause analysis (RCA) is used to investigate serious or
high-frequency errors but is limited by its inability to explain a broader scope of factors
We re-reviewed RCA cases to understand the underlying human organizational or system-
ic factors affecting AMEs Methods A total of 40 consecutive RCA cases (2012-2016) were
retrieved from the AMEs database A panel was organized to retrospectively re-review these
cases using the Human Factor Analysis and Classification System HFACS Results For
active failures errors stemmed largely from performance-based (95) judgment and deci-
sion-making errors (875) Incorrectly followed procedures (816) and accidental
equipment operation (50) were the most common types of performance-based errors In-
adequate real-time assessment (686) and inappropriate operative actions (686) were
the most common decision-making errors For sources of latent failure teamwork problems
(275) including failure to effectively communicate (818) and communicate critical
information (727) were common Inadequate supervision (929) or command over-
sights (929) were the most common problems related to inadequate supervision (35)
Organizational programpolicy risks not adequately assessed (50) were the most common
problems related to policy and process problem (25) Conclusions The HFACS review
enhances our understanding of human factors underlying AMEs The HFACS reveals latent
supervisory organizational or systematic problems that cannot be addressed through tradi-
tional RCA Keywords patient safety adverse events root cause analysis human factors
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 100
INTRODUCTION Patient safety involves the reduction of patient
harm from potentially avoidable unintended
outcomes [1] Studies have revealed that 50ndash
80 of adverse medical events (AMEs) are pre-
ventable [2-4] to eliminate such errors the ap-
propriate management of AMEs hence repre-
sents the cornerstone of patient safety work
Through incident reporting investigation and
analysis healthcare providers can correct or
re-engineer their care processes to prevent inci-
dent recurrence [25] One of the most popular
tools for investigating AMEs is root cause anal-
ysis (RCA) RCA reconstructs a chain of errors
to identify the deviation of care from normal
processes Nonetheless with a lack of standard-
ized nomenclature and investigation procedures
RCA report conclusions are sometimes too sub-
jective and nonspecific to facilitate any actiona-
ble safety improvement plans [5-7] According
to the UK Health and Safety Executive defini-
tion human factors are environmental organiza-
tional occupational or individual human char-
acteristics which influence behavior at work
such that health and safety are affected [8] Hu-
mans and systems are prone to errors and stud-
ies have showed that nearly 70 of medical
errors involve human factors [2-4] Reasonrsquos
Swiss cheese model described the penetration of
causative human errors through layers of defen-
sive barriers leading to system collapse [9]
With much focus on the temporal sequence and
severity of departure from accepted practices in
an incident the effectiveness of RCA is often
challenged by its incapability of exploring un-
derlying human organization or even systemic
factors [5-7] Reason and others have proposed
that errors can occur at 4 levels 1) unsafe acts
(operator actions) 2) preconditions for unsafe
acts (environmental factors contributing to er-
rors) 3) inadequate supervision (management
actions affecting the operator) and 4) organiza-
tional influences (organizational culture policies
and procedures that affect the operator) [9]
Based on this theory Wiegmann and Shappell
developed the Human Factor Analysis Classifi-
cation System (HFACS) to describe human fac-
tors causing accidents from 4 tiers of categories
Each of these categories consists of nanocodes to
represent specific human behavior or system
problems leading to errors [9-10] The tier for
unsafe acts involves actual provider actions (er-
rors or rule violations) directly leading to events
The tier representing preconditions for unsafe
acts includes operational personnel and envi-
ronmental factors The supervision tier addresses
leadership problems operational planning fail-
ure or correction and supervisory ethics The
tier for organizational influences deals with re-
source management organizational climate and
operational processes (Supplement Table 1) The
HFACS provides standardized investigation
processes for the systematic analysis of common
causes of adverse events across national defense
nuclear power navy aviation and healthcare
industries Taiwan launched its nationwide
AME-reporting system the Taiwan Patient
Safety Reporting System (TPR) in 2004 RCA
methodology was subsequently introduced to the
healthcare industry by the Joint Commission of
Taiwan [11] Since 2012 appropriate manage-
ment of AMEs has been listed as a national pa-
tient safety goal [12] RCA is required by the
Ministry of Health and Welfare for major AMEs
Aside from RCA a comprehensive structural
reliable and valid framework is urgently re-
quired to further guide organizational or even
national patient safety policies In this study we
used the HFACS to review our RCA cases aim-
ing to investigate human factors underlying se-
vere or frequent AMEs
MATERIALS AND METHODS Through continuous sampling 40 consecutive
RCA cases (2012-2016) were retrieved from a
hospitalrsquos (Cathay General Hospital Taipei
Taiwan) AME-reporting system database The
database contains AMEs relating to areas such as
medication patient falls surgery transfusion
clinical care public accidents security hospital
violence tube-related complication unplanned
cardiopulmonary resuscitation laboratory testing
and examination and anesthesia The RCA cases
were sentinel or high-frequency events classified
according to severity assessment category (SAC)
[1113] The SAC is an evaluation method for
categorizing AMEs by severity of effect on pa-
tients health and risk of incident reoccurrence
The HFACS has been modified (from the US
Department of Defense version 70) and trans-
lated into Mandarin Chinese with authorization
from the original developers [10] The Chi-
nese-version HFACS for Taiwan is a valid in-
strument (content validity index 09 Cronbachrsquos
α gt07 interrater reliability Κ 04-10) equiva-
lent to the original English version [9] The
HFACS contains 4 tiers 13 subitems and 109
nanocodes (Supplement Table 1) A panel of 6
reviewers was established All reviewers were
from clinical or management (quality and patient
safety management) backgrounds Reviewers all
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 101
finished human factor education and were
trained to use the HFACS through a consensus
meeting Each RCA case was randomly assigned
to 2 reviewers Human factors leading to partic-
ular AMEs were identified and confirmed when
2 reviewers reached agreement The distribution
of errors among tiers subitems and nanocodes
are provided with descriptive statistics () The
study was approved by the Institutional Review
Board of Cathay General Hospital
(CGH-P105095)
RESULTS AMEs related to laboratory testing and examina-
tion (n = 16) clinical care (n = 9) and medica-
tion (n = 7) were the most commonly observed
in the RCA Most AMEs in this cohort are
ranked as being SAC level 3 (n = 15) or 4 (n =
17) (Table 1)
Acts (Active Failures)
This tier of errors contains 3 subitems and 13
nanocodes In the 40 RCA cases perfor-
mance-based errors for 38 (95) and judgment
and decision-making errors for 35 (875) com-
prised the most common error types with viola-
tion for 6 (15) less common Procedure fol-
lowed incorrectly for 31 out of 38 (816) was
the most common performance-based problem
Inadequate real-time risk management for 24 out
of 35 (686) was the most common judgment
or decision error All of the rule violations were
workaround types for 6 out of 6 (100) (Figure
1)
Preconditions(Latent Failures)
This tier of errors has 9 subitems and 58 nano-
codes In the 40 RCA cases teamwork for 11
(275) and environmental for 8 (20) factors
contributed to most of the errors with mental
and physical state the next most common factor
for 7 (175) Communication for 9 out of 11
(818) and information relay for 8 out of 11
(727) were the most common issues related to
teamwork Few contributors mentioned failures
related to technical errors for 4 (50) or physi-
cal for 1 (125) environment Not paying at-
tention for 4 out of 7 (571) and negative habit
transfer for 4 out of 7 (571) were common
mental contributes noted for 7 (100) Overcon-
fidence was the most common problem related
to emotional status for 4 out of 7 (571) Fa-
tigue was observed in only 2 cases for 2 out of 2
physical problems (100) (Figure 2)
Supervision(Direct Supervisory Chain of
Command)
This tier of errors contains 3 subitems and 17
nanocodes In the 40 RCA cases inadequate
supervision for 14 (35) and inappropriately
planned operations for 11 (275) factors con-
tributed to most of the respective errors fol-
lowed by supervisory violations for 7 (175)
Supervisory or command oversights for 13 out
of 14 (929) were the most common sources of
supervision inadequacy Authorized unnecessary
hazards for 7 out of 11 (636) were the most
common inappropriately planned operations
Failure to enforce rules for 6 out of 7 (857)
was the most common supervisory violation
(Figure 3)
Organization Influence (Upper-Level Man-
agement)
This tier of errors contains 4 subitems and 18
nanocodes In the 40 RCA cases policy and
process issues for 10 (25) and resources prob-
lem for 8 (20) were major concerns Few of
the respective problems are related to climate
and cultural influences for 2 (5) or to person-
nel selection and staffing for 1 (25) Poorly
assessed organizational programs or policy risks
for 5 out of 10 (50) were the most common
policy and process problems Failure to provide
adequate operational information resources for 4
out of 8 (50) and command and control re-
source deficiency for 3 out of 8 (375) were
the main resource management problems Little
was revealed regarding organizational climate
and culture (n = 1 out of 2 50) or staffing for 1
out of 1 (100) (Figure 4)
DISCUSSION Health care is a complex system comprising
many high-reliability organizations (HROs) The
vulnerability of HROs stems from the participa-
tion of multidisciplinary teams in the processes
along a variety of patient care timelines How-
ever humans and systems are inherently prone
to errors the appropriate management of AMEs
is acknowledged to be the cornerstone of patient
safety AMEs should be reported investigated
analyzed and handled appropriately[14] Theo-
retically by analyzing the pattern of key defects
providers can fix errors and re-engineer their
care processes to reduce the possibility of AME
recurrence Taiwan established its nationwide
TPR in 2004 so far 7000 health care facilities
have participated and the database has accumu-
lated more than 055 million AMEs[11] Infor-
mation generated from the TPR database can
improve patient safety at individual organiza-
tional or even national levels However despite
relentless efforts few substantial improvements
have been achieved in patient safety [15-17]
Since its introduction in Taiwan in 2006 the use
of RCA for AMEs has encountered some diffi-
culties 1) No structural and standardized
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 102
framework exists for investigation
cross-institution variability and interrater relia-
bility are often ignored 2) Conclusions are often
subjective and corrective recommendations are
less actionable relying on individual reviewersrsquo
professional backgrounds and their experiences
3) Much focus on event reconstruction and oper-
ator performance means that factors relating to
human behavior organizational culture and
system weakness are not comprehensively ad-
dressed [671718] Traditionally attempts to
improve patient safety in the health care industry
are largely reactive in nature identifying and
correcting errors in care processes [1920]
Causes of defects are not thoroughly understood
Proactive approaches must be taken to address
systematic problems within a complex system
[720] Research suggests that human error is a
causal factor in the occurrence of AMEs AME
investigation targets have moved from skill defi-
ciency toward decision-making attitudes super-
visory factors and even organizational climate
or culture HFACS methodology is based on the
Swiss cheese model that also emphasizes active
and latent failures [921] The study provides
some noteworthy findings First most AMEs as
expected involve active failures such as failure
to follow procedure accidental operation of
equipment inadequate real-time risk manage-
ment and inappropriate action These are all
sharp ends in classic RCA environment physi-
cal and mental factors are less prevalent This
proves that retrospectively determining addi-
tional causal factors is difficult when infor-
mation has not been collected during preliminary
investigation (Figure 1) Second team-
work-related problems particularly in relation to
communication and information relay are well
addressed This may be attributed to the dec-
ade-long institution-wide routine crew resource
management training in the respective research
hospital (Figure 2) Third the HFACS success-
fully reflects the importance of supervisory roles
in the occurrence of AMEs and this cannot be
overlooked (Figure 3) Fourth latent failures
especially in organizational climate or cultural
dimensions have been less frequently addressed
in incident reports a limitation of traditional
RCA However the HFACS review suggests
room for improvement in resource allocation and
policy modification within the hospital The
results of studies can make the organization
think about how to improve the patient safety
and management process from the perspective of
human factors such as improving the comfort of
the working environment and replacing and
equipment resources to prevent personnel from
affecting the medical quality and patient safety
due to the environment or equipment Need to
appropriate assessment of applicability and ade-
quate training of manpower is required The
management and control of risks should be fully
evaluate and grasp resource management and
leaders need to participate in and promote medi-
cal quality and patient safety activities to en-
hance its culture (Figure 4) No panacea exists
to ensure patient safety and improvement targets
originate largely from event investigation find-
ings Unfortunately factors identified from
AMEs are often self-explanatory with little value
for further action correction Reinforcement of
policy or processes redundant education or
repetitious training are formulaic overprescribed
RCA recommendations The use of HFACS in
this study proves that a structural prospective
AME investigation format can potentially help
with proactive patient safety management We
suggest developing an interview guideline for
the routine use of HFACS as a complement to
RCA in every AME investigation This study is a
retrospective study The underlying human fac-
tors can be under-estimated owing to the lack of
related information in the original RCA reports
CONCLUSION The HFACS review in this study enhances our
understanding of human factors in AMEs that
had previously been insufficiently scrutinized
Aside from active process and communication
errors the HFACS enables the prospective in-
vestigation of latent supervisory organizational
or systematic problems that cannot be addressed
through traditional RCA
REFERENCES 1 T Brennan L Leape N Laird et al
Incidence of adverse events and
negligence in hospitalized patients results
of the Harvard Medical Practice Study I N
Engl J Med 1991324370-376
2 Wang CH Shih CL Chen WJ et al
Epidemiology of medical adverse events
perspectives from a single institute in
Taiwan J Formos Med Assoc
2016115434-439
3 Vincent C Simon R Sutcliffe K et al
Errors Conference Executive Summary
Acad Emerg Med 200071180-1182
4 Taitz J Genn K Brooks V et al
System-wide learning from root cause
analysis A report from the New South
Wales Root Cause Analysis Review
Committee Qual Saf Health Care
2010191-5
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 103
5 Hutchinson A Young TA Cooper KL et
al Trends in healthcare incident reporting
and relationship to safety and quality data
in acute hospitals results from the
National Reporting and Learning System
Qual Saf Health Care 2009185-10
6 Mitchell RJ Williamson AM Molesworth
B et al A review of the use of human
factors classification frameworks that
identify causal factors for adverse events
in the hospital setting Ergonomics
2014571443-1472
7 Gurses AP Ozok AA Pronovost PJ Time
to accelerate integration of human factors
and ergonomics in patient safety BMJ
Qual Saf 201221347-351
8 Health and Safety Executive Introduction
to human factors
httpwwwhsegovukhumanfactorsintro
ductionhtm
9 Wiegmann DA Shappell SA A human
error approach to aviation accident
analysis The human factors analysis and
classification system Burlington VT
Ashgate Publishing Ltd 2003
10 Yu-Hsun Cheng Sheng-Hui Hung
Tung-Wen Ko et al An Analysis of the
Reliability and Validity of Human Factors
Analysis Classification System in Medical
Adverse Events Journal of Healthcare
Quality 20191370-76
11 Taiwan Joint Commission on Hospital
Accreditation Taiwan Patient-Safety
Reporting System Annual Report 2017
New Taipei City Taiwan
12 Taiwan Patient Safety Net
httpwwwpatientsafetymohwgovtwCo
ntentzMessagesslistaspxSiteID=1ampMm
mID=621273300317401756
13 Government of Western Australia
Department of Health
httpsww2healthwagovauArticlesS_T
Severity-assessment-codes
14 Farley DO Haviland A Champagne S et
al Adverse-event-reporting practices by
US hospitals results of a national survey
Qual Saf Health Care 200817416-423
15 Shojania KG Thomas EJ Trends in
adverse events over time why are we not
improving BMJ Qual Saf
201322273-277
16 Levitt P Challenging the systems approach
why adverse event rates are not improving
BMJ Qual Saf 2014231051-1052
17 Kellogg KM Hettinger Z Shah M et al
Our current approach to root cause
analysis is it contributing to our failure to
improve patient safety BMJ Qual Saf
201726381-387
18 Khorsandi M Skouras C Beatson K et al
Quality review of an adverse incident
reporting system and root cause analysis of
serious adverse surgical incidents in a
teaching hospital of Scotland Patient Saf
Surg 2012621
19 Diller T Helmrich G Dunning S et al
The Human Factors Analysis
Classification System (HFACS) Applied to
Health Care Am J Med Qual
201429181-190
20 Carayon P Xie A Kianfar S Human
factors and ergonomics as a patient safety
practice BMJ Qual Saf 201423196-205
21 Reason J Human Error New York
Cambridge University Press 1990
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 104
TABLE
Table 1 Incidences by Category (N=40)
CategorySAC SAC 4 SAC 3 SAC 2 SAC 1 total
Laboratory and ex-
amination events
4 10 2 0 16 (400)
Clinical care event 6 2 1 0 9 (225)
Medication event 5 0 2 0 7 (175)
Surgery-related event 1 1 2 0 4 (100)
Transfusion-related
event
1 1 0 0 2 (50)
Tube event 0 1 0 0 1 (25)
Public accident 0 0 1 0 1 (26)
Total 17 (425) 15 (375) 8 (200) 0 40 (100)
SAC 1113 Severity Assessment Code SAC
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 105
FIGURES
Figure 1 Active Failures (N=40)
16 (167)
66 (1000)
640 (150)
235 (57)
735 (200)
2435 (686)
2435 (686)
3540 (875)
438 (105)
438 (105)
738 (184)
1938 (500)
3138 (816)
3840 (950)
0 5 10 15 20 25 30 35 40
Commits WidespreadRoutine Violation
Performs Work-Around Violation
Ignored a CautionWarning
Failure to Prioritize Tasks Adequately
Wrong Choice of Action During an Operation
Inadequate Real‐Time Risk Assessment
Rushed or Delayed a Necessary Action
Breakdown in Visual Scan
Over-ControlledUnder-Controlled AircraftVehicleSystem
Unintended Operation of Equipment
Procedure Not Followed Correctly
Performance-Based Errors
Judgment and Decision Making Errors
Violations
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 106
Figure 2 Preconditions (Latent Failures or Conditions) (N=40)
14 (250)
24 (500)
48 (500)
11 (1000)
18 (125)
840 (200)
0 5 10 15 20 25 30 35 40
Seat and Restraint System Problems
Instrumentation amp Warning System Issues
Noise Interference
Environment
Physical Environment
Technological Environment
27 (286)
27 (286)
27 (286)
37 (129)
47 (511)
47 (571)
77 (1000)
24 (500)
44 (1000)
47 (571)
12 (500)
22 (1000)
27 (286)
740 (175)
0 5 10 15 20 25 30 35 40
Technical or Procedural Knowledge Not Retained After Training
InterferenceInterruption
Task OverUnder Saturation
Distraction
Negative Habit Transfer
Not Paying Attention
Complacency
Overconfidence
Physical IllnessInjury
Fatigue
Physical and Mental State
Physical Problem
State of Mind
Mental Awareness
211 (182)
311 (273)
311 (273)
411 (364)
811 (7227)
911 (818)
1140 (275)
0 5 10 15 20 25 30 35 40
Inadequate Task Delegation
TaskMission PlanningBriefingDebriefing Inadequate
Failure of CrewTeam Leadership
StandardProper Terminology Not Used
Critical Information Not Communicated
Failed to Effectively Communicate
Teamwork
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 107
Figure 3 Supervision (Direct Supervisory Chain of Command) (N=40)
Figure 4 Organization Influence (Upper-Level Management Command Level) (N=40)
114 (71)
114 (71)
214 (143)
314 (214)
1314 (929)
1440 (350)
511 (455)
511 (455)
711 (636)
1140 (275)
47 (571)
67 (857)
740 (175)
0 5 10 15 20 25 30 35 40
Selected Individual with Lack of Proficiency
Improper Role‐modeling
Failed to Provide Proper Training
Failed to IdentifyCorrect Risky or Unsafe Practices
SupervisoryCommand Oversight Inadequate
Performed Inadequate Risk Assessment ‐Formal
Selected Individual with Lack of Current or Limited Experience
Authorized Unnecessary Hazard
Allowing Unwritten Policies to Become Standard
Failure to Enforce Existing Rules
Supervisory Violations
Planned Inappropriate Operations
Inadequate Supervision
12 (500)
12 (500)
240 (50)
110 (100)
510 (500)
1040 (250)
11 (1000)
140 (25)
18 (125)
18 (125)
38 (35)
48 (500)
840 (200)
0 5 10 15 20 25 30 35 40
Organizational Over-confidence or Under-confidence in Equipment
Organizational Culture (attitude actions) Allows for Unsafe TaskMission
Purchasing or Providing Poorly Designed or Unsuitable Equipment
Organizational ProgramPolicy Risks not Adequately Assessed
Failure to Provide Adequate Manning Staffing Resources
Failure to remove inadequate worn-out equipment in timely manner
Inadequate infrastructure
Command and control resources are deficient
Failure to provide adequate operational information resources
Resource Problems
Personnel Selection amp Staffing
Policy and Process Issues
ClimateCulture Influences
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 108
Supplement Table 1- HFACS Content of Human Factor Analysis Classifi-
cation System [9] Tier main level sub-item nano code
Tier 1 Unsafe Acts
Perfor-
mance-Based
Errors
Unintended operation of equipment
Checklist not followed correctly
Procedure not followed correctly
Over-controlledunder-controlled aircraftvehiclesystem
Breakdown in visual scan
Rushed or delayed a necessary action
Judgment amp De-
cision-Making
Errors
Inadequate real‐time risk assessment
Failure to prioritize tasks adequately
Ignored a cautionwarning
Wrong choice of action during an operation
Violations
Performs work-around violation
Commits widespreadroutine violation
Extreme violation-lack of discipline
Tier 2 Preconditions
Environment
Physical environment
Environmental conditions affecting vision
Vibration effects vision or balance
Heatcold stress impairs performance
External force of object impeded an individualrsquos
movement
Lights of other vehiclevesselaircraft affected vision
Noise interference
Technological environment
Seat and restraint system problems
Instrumentation amp warning system issues
Visibility restrictions (not weather related)
Controls and switches are inadequate
Automated system creates unsafe situation
Workspace incompatible with operation
Personal equipment interference
Communication equipment inadequate
Physical and
Mental State
Physical problem
Substance effects (alcohol supplements medications
drugs)
Loss of consciousness (sudden or prolonged onset)
Physical illnessinjury
Fatigue
Inadequate adaptation to darkness
Dehydration
Body sizemovement limitations
Physical strength amp coordination (inappropriate for
task demands)
Nutritiondiet
State of mind
Psychological problem
Life stressors
Emotional state
Personality style
Overconfidence
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 109
Pressing
Complacency
Motivation
Motivational exhaustion (burnout)
Sensory misperception
Motion illusion-kinesthetic
Turning illusionbalance-vestibular
Visual illusion
Misperception of changing environment
Misinterpreted misread instrument
Misinterpretation of auditorysound cues
Spatial disorientation
Temporaltime distortion
Mental awareness
Not paying attention
Fixation
Task overunder saturation
Confusion
Negative habit transfer
Distraction
Geographically lost
Interferenceinterruption
Technical or procedural knowledge not retained after
training
Inaccurate expectation
Teamwork
Failure of crewteam leadership
Inadequate task delegation
Rankposition intimidation
Lack of assertiveness
Critical information not communicated
Standardproper terminology not used
Failed to effectively communicate
Taskmission planningbriefingdebriefing inadequate
Tier 3 Supervision
Supervisory Vio-
lations
Failure to enforce existing rules
Allowing unwritten policies to become standard
Directed individual to violate existing regulations
Authorized unqualified individuals for task
Planned Inappro-
priate Operations
Directed task beyond personnel capabilities
Inappropriate team composition
Selected individual with lack of current or limited experience
Performed inadequate risk assessment ‐formal
Authorized unnecessary hazard
Inadequate Su-
pervision
Supervisorycommand oversight inadequate
Improper role‐modeling
Failed to provide proper training
Failed to provide appropriate policyguidance
Personality conflict with supervisor
Lack of supervisory responses to critical information
Failed to identifycorrect risky or unsafe practices
Selected individual with lack of proficiency
Tier 4 Organizational
Influences
Resource Prob-
lems
Command and control resources are deficient
Inadequate infrastructure
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 110
Failure to remove inadequate worn-out equipment in timely
manner
Failure to provide adequate operational information resources
Fail to provide adequate funding
Personnel Selec-
tion amp Staffing
Personnel recruiting amp selection policies are inadequate
Failure to provide adequate manning staffing resources
Policy amp Process
Issues
Pace of ops-tempoworkload
Organizational programpolicy risks not adequately assessed
Provided inadequate procedural guidance or publications
Organizational (formal) training is inadequate or unavailable
Flawed doctrinephilosophy
Inadequate program management
Purchasing or providing poorly designed or unsuitable equip-
ment
ClimateCulture
Influences
Organizational culture (attitude actions) allows for unsafe
taskmission
Organizational over-confidence or under-confidence in equip-
ment
Unit missionaircraftvehicleequipment change or unit deacti-
vation
Organizational structure is unclear or inadequate
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 111
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
以 HFACS重新檢視根本原因分析案例挖掘造成醫療不良
事件之人為因素
鄭伃洵 1洪聖惠 12柯彤文 3王拔群 14
中文摘要
背景醫療不良事件(AMEs)的管理是促進病人安全的基石根本原因分析
(RCA)是探討重大病人安全不良事件問題但是由於無法解釋更廣泛的因素而受
到限制本研究使用人為因素分類與分析工具(HFACS)回溯審視醫療不良事件
以了解影響醫療不良事件的人為因素及各層面中錯誤原因之分佈或系統性問題
方法本研究回溯 2012-2016年間有做過根本原因分析之醫療不良事件以連續
性取樣方式(continuous sampling)收集 40例醫療不良事件以人為因素分類與分
析工具(HFACS)去系統性的挖掘每件案例發生錯誤之原因結果在行為層面中
分析結果主要為基礎技能錯誤(95)判斷和決策錯誤(875)其中在基礎技能
錯誤當中以未依程序作業執行(816)及未如預期設備操作(50)佔多數判斷和
決策錯誤中以現場風險評估不確實(686)及採取錯的步驟行為(686)佔多數
而在先決條件層面中以團隊合作(275)為主要因素包含溝通不良(818)及重
要訊息未以正確的方式即時傳達(727)佔多數在監督層面當中以監督不周
(929)或監督不妥當(929)為主要因素在組織政策和流程方面(50)以組織
系統的政策風險未充分評估(35)為主要因素結論本研究進一步了解醫療不
良事件在過去使用根本原因分析未探討到的人為因素反映出潛在的監督組織
行為或系統性的問題促進病人安全預防錯誤再發生
關鍵字病人安全醫療不良事件根本原因分析人為因素
1國泰醫療財團法人國泰綜合醫院 品質管理部
2國立臺灣大學健康政策與管理研究所
3振興醫療財團法人振興醫院 醫療品質管理中心
4輔仁大學醫學院
通訊作者王拔群 電子信箱 drtonyseednettw
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin 112
Submitted January 20 2020
Final version accepted April13
2020
Case Report
Juvenile Caruncular Atypical Lymphoid
Proliferation ndash A Rare Case Report
Cite as Hua-Wei Shih Yu-Chi Lin
Juvenile Caruncular Atypical
Lymphoid Proliferation ndash A Rare
Case Report Fu-Jen Journal of
Medicine 3(3) 112-119 2020
DOI
103966181020932020091803003
Hua-Wei Shih1 Yu-Chi Lin
1
1Department of Ophthalmology Shin Kong Wu Ho-Su Memorial Hos-
pital Taipei City Taiwan
Corresponding author E-mail address
yuchi067gmailcom (Yu-Chi Lin)
ABSTRACT
Lesions of the caruncle are very rare Most caruncular lesions are benign though there were still few reported malignant lesions Ocular adnexal lymphoproliferative disease (OALD) one of the differential diagnosis of caruncular lesion is seldom seen in young pa-tient In this article we report a 16-year-old boy with recurrent caruncular atypical lym-phoid proliferation We discuss the epidemiology clinical features images histomorpholo-gy and treatment between ocular adnexal lymphomas (OAL) and reactive lymphoid hyper-plasia (RLH)
Keywords caruncular lesion ocular adnexal lymphoproliferative disease ocular adnexal lymphoma
reactive lymphoid hyperplasia atypical lymphoid proliferation
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
113
INTRODUCTION Lesions of the caruncle are very rare Differen-
tial diagnosis includes nevus myeloproliferative
disorders tumors inflammation infection cysts
vascular lesions and fibrous Biopsy is essential
for diagnosis Levy J et al reported ocular ad-
nexal lymphoproliferative disease (OALD) was
relatively uncommon diagnosis among caruncu-
lar lesions [1]
OALD was seldom described in Asian popula-
tion especially for young age C-Y Cheng re-
ported age-standardized incidence of ocular
adnexal lymphomas (OAL) in Taiwan from 1979
to 1996 was below 07 per million per year and
mean age was 531 years old [2] In 2015 five
Taiwanese cases of OAL whose age ranging
from 45 to 64 were presented [3] However
there were few cases of conjunctival OAL or
RLH in Chinese pediatric patient
Here we present a case of 16-year-old boy with a
caruncular mass at his left eye with recurrence
one month after excision We describe his clini-
cal symptoms photographs pathological results
management and follow-up clinical course in
this report
CASE REPORT A 16-year-old healthy boy presented a mass
lesion at his left eye caruncle accompanied with
the symptom of tearing for one month (Figure 1)
He had no ocular pain no itchiness no blurred
vision no night sweating no fever and no body
weight loss The patient denied systemic diseas-
es and histories of surgery His bilateral best
corrected visual acuity (BCVA) were 66 and
intraocular pressure (IOP) were both within
normal range There were no remarkable find-
ings for his cornea lens fundus and physical
examination Excision was performed and the
mass was soft with fluid inside therefore con-
junctival pyogenic cyst was our initial diagnosis
However one month after the excision a pro-
truding mass recurred at the patientrsquos nasal can-
thus of left eye (Figure 2) There were some
differences compared to previous condition At
the first time the soft mass was contained in a
well-defined cyst wall which more favored py-
ogenic granulation However after short period
of recurrence solid consistency and unclear
margin were found which favored malignancy
Besides the mass partially involved beyond the
gray line of nasal part lower eyelid whereas last
time the cyst mainly extended from conjunctiva
of caruncle The second excisional biopsy was
performed Pathologic examination demonstrat-
ed abundant atypical lymphoid proliferation
(Figure 3A 3B) Immunohistochemical studies
showed that the lymphoid aggregation was
composed predominantly of CD20-positive cells
(Figure 3C) focal positive staining of CD3
(Figure 3D) CD5 CD23 CD10 and negative
staining of cyclin-D1 Unfortunately the cellular
morphology was difficult to be evaluated due to
marked crushing artifact Thus malignant lym-
phoma cannot be excluded totally
Orbital computed tomography (CT) showed a
lesion of soft tissue density at medial canthus of
left orbit without obvious nasolacrimal duct or
bony invasion (Figure 4A) Magnetic resonance
imaging (MRI) with contrast showed strong
enhancement at left medial canthus region (Fig-
ure 4B) There was no remarkable finding in the
systemic workup including complete blood
count and differential count biochemical pro-
files and 18F-fluoro-2-deoxyglucose positron
emission tomographycomputed tomography
(18F-FDG PETCT) indicating no evidence of
systemic involvement
After the second excision we preferred con-
servative management for him due to the uncer-
tainty of malignancy and to avoid side effects
from aggressive treatment No sign of recurrence
was noted after 10 months of observation The
follow-up photo was taken at three months after
the second operation (Figure 5)
DISCUSSION Ocular adnexal lymphoproliferative disease
(OALD) consists of the spectrum of lymphoid
disease affecting the tissues surrounding the eye
including ocular adnexal lymphomas (OAL) and
lymphoid hyperplasia (LH) [4] The conjunctiva
is an important location for extranodal lympho-
ma development which comprises 25 of OAL
[5]
OAL can be grouped into two categories based
on their appearance of cells under the micro-
scope low-grade and high-grade [6] Extranodal
marginal zone lymphoma of mucosa-associated
lymphoid tissue (EMZLMALT) is the most
common subtype of OAL followed by follicular
lymphoma [7-9] Both of the above are
low-grade lymphomas
LH can be further divided by histopathology into
reactive lymphoid hyperplasia (RLH) and atypi-
cal lymphoid hyperplasia (ALH) RLH has to-
tally benign morphology and immunophenotype
whereas ALH has borderline lesions between
RLH and lymphoma [10] OAL and LH are
mostly seen in patients with age between 50-70
years old There are rare cases in pediatric group
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
114
[71011] In the C-Y Chengrsquos statistical report of
OAL in Taiwan only 8 patients were younger
than 15 years old among the 101 cases of ocular
lymphoma [2] According to an US study inci-
dence rates of OAL were analyzed in different
age groups the group of age over 50 had the
highest incidence rate of 574 per million per-
son-years while the 0-19 age group had the
lowest incidence rate of 009 per million per-
son-years [12] The incidence of LH was even
less than OAL [13]
Patients with OALD may be asymptomatic or
with symptoms of proptosis eyelid swelling a
palpable painless mass or conjunctival salmon
patch Diplopia visual loss pain or inflamma-
tion occurred less frequently implying more
aggressive features [714]
Orbital LH is not distinguishable from low-grade
lymphoma radiologically They both typically
present a round or lobulated mass that diffusely
moderately enhances with contrast and usually
shows homogenous hypointense or isointense to
muscle barely invasion to bone or nervous sys-
tem [10] Atypical appearances including inho-
mogeneous calcification or bony changes may
be seen in high-grade lymphoma case reports
such as ocular adnexal diffuse large B-cell lym-
phoma (DLBCL) which is one of the more ag-
gressive type of OAL [7] Whole body PET is
used for not only the evaluation of systemic
involvement but also the standard for staging
lymphoma Our patientrsquos image studies revealed
neither obvious local invasion nor systemic ma-
lignancy indicating high-grade lymphoma was
less likely Low-grade lymphoma and benign
reactive lymphoid hyperplasia were still under
consideration
Histomorphology analysis and immunohisto-
chemistry (IHC) are essential for diagnosis
Flow cytometry and polymerase chain reaction
(PCR) technique are also applied to help differ-
entiate from RLH and OAL [1016] Our case
had immunohistochemical profile of positivity
for CD20 predominantly positivity focally for
CD3 CD5 CD10 CD23 and negativity for cy-
clin-D1 BCL-6 staining was not performed in
our casersquos biopsy Thus according to the IHC
report RLH ALH and follicular lymphoma are
probable diagnosis of our patient
Radiation therapy is the standard treatment for
low-grade OAL that is classified as T1N0M0 or
T2N0M0 according to the AJCC criteria [15]
İncesoy-Ouml zdemir S et al reported a 10-year-old
boy diagnosed of MALT lymphoma who was
treated with local radiotherapy (36 Gy) and
there were no local or systemic recurrences dur-
ing his nearly four-year follow-up [17] Another
case report represented a 21-year-old man of
conjunctival follicular lymphoma treated with
surgical excision only showing no evidence of
recurrence after 8 months follow-up [18] Other
treatment options for pediatric and juvenile OAL
were performed in some case reports including
intravenous rituximab intralesional interfer-
on-α-2b topical interferon a6 systemic doxycy-
cline surgical excision and postoperative local
cryotherapy [15]
Treatment for young conjunctival RLH was less
discussed in the past In a case series article
three children (9 13 14 years old respectively)
of RLH received surgical resection without fur-
ther postoperative management and no signs of
recurrence were noted during follow-up [19]
Short-term topical and oral corticosteroids after
surgical excision were prescribed in two pediat-
ric RLH patients for their small residual mass
However poor response in both cases was nota-
ble [20]
Our patient declined to receive radiotherapy or
any further postoperative treatment mainly due
to his concerning of possible side effects (such
as dry eye and cataract)
CONCLUSION We present a rare case of caruncle mass in this
report OALD is one of the relatively uncommon
diagnosis among caruncular lesions OALD
includes benign RLH and malignant OAL
which are both mainly seen in elderly patients
even rarer in pediatric or juvenile group
The standard treatment for low-grade OAL and
RLH in young patents are still debatable How-
ever long-term follow-up is suggested for both
OAL and RLH patients Though RLH has a be-
nign and self-limited course risk of malignant
transformation is possible
REFERENCES 1 Levy J Ilsar M Deckel Y et al Lesions of
the caruncle a description of 42 cases and
a review of the literature Eye
200923(5)1004-1018
2 C-Y Cheng and W-M Hsu Incidence of
eye cancer in Taiwan an 18-year review
Eye 200418152-158
3 Chui-Lien Tsen Muh-Chiou Lin
Youn-Shen Bee et al Ocular adnexal
lymphoma Five case reports and a
literature review Taiwan Journal of
Ophthalmology 20155(2)99-102
4 Liesegang TJ Ocular adnexal
lymphoproliferative lesions Mayo Clin
Proc 199368(10)1003-1010
5 Kirkegaard MM Coupland SE Prause JU
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
115
et al Malignant lymphoma of the
conjunctiva Surv Ophthalmol
201560(5)444-458
6 Stacy RC Jakobiec FA Schoenfield L et
al Unifocal and multifocal reactive
lymphoid hyperplasia vs follicular
lymphoma of the ocular adnexa Am J
Ophthalmol 2010150(3)412-426
7 Sullivan TJ Ocular Adnexal
Lymphoproliferative Disease In Guthoff
RF Katowitz JA eds Oculoplastics and
Orbit Berlin Heidelberg Springer
20101-19
8 White Valerie A Understanding and
Classification of Ocular Lymphomas
Ocular Oncology and Pathology
20195379-386
9 Stefanovic A Lossos IS Extranodal
marginal zone lymphoma of the ocular
adnexa Blood 2009114(3)501-510
10 Andrew NH Coupland SE Pirbhai A et al
Lymphoid hyperplasia of the orbit and
ocular adnexa A clinical pathologic review
Surv Ophthalmol 201661(6)778-790
11 Ferry JA1 Fung CY Zukerberg L et al
Lymphoma of the ocular adnexa A study
of 353 cases Am J Surg Pathol
200731(2)170-184
12 WM Hassan MS Bakry HM Hassan et al
Incidence of orbital conjunctival and
lacrimal gland malignant tumors in USA
from Surveillance Epidemiology and End
Results 1973-2009 Int J Ophthalmol
20169(12)1808-1813
13 Ajay A Rao John H Naheedy James Y-Y
Chen et al A Clinical Update and
Radiologic Review of Pediatric Orbital
and Ocular Tumors Journal of Oncology
2013(9)975908
14 Sullivan TJ Whitehead K Williamson R
et al Lymphoproliferative disease of the
ocular adnexa a clinical and pathologic
study with statistical analysis of 69
patients Ophthal Plast Reconstr Surg
200521177-188
15 Tanenbaum RE Galor A Dubovy SR et al
Classification diagnosis and management
of conjunctival lymphoma Eye Vis (Lond)
2019622
16 Olga Klavdianou Georgios Kondylis
Vasileios Georgopoulos et al Bilateral
benign reactive lymphoid hyperplasia of
the conjunctiva a case treated with oral
doxycycline and review of the literature
Eye Vis (Lond) 2019626
17 İncesoy-Ouml zdemir S Yuumlksek N Bozkurt C
et al A rare type of cancer in children
extranodal marginal zone B-cell (MALT)
lymphoma of the ocular adnexa Turk J
Pediatr 201456(3)295-298
18 Lynn J Poole Perry Frederick A Jakobiec
Peter A D Rubin Conjunctival Pediatric
Follicular Lymphoma Arch Ophthalmol
2012130(7)941-943
19 Abdullah Al-Mujaini Upender Wali
Anuradha Ganesh1 et al Ocular Adnexal
Reactive Lymphoid Hyperplasia in
Children Middle East Afr J Ophthalmol
201219(4)406-409
20 McLeod SD Edward DP Benign
lymphoid hyperplasia of the conjunctiva in
children Arch Ophthalmol
1999117(6)832-835
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
116
FIGURES
Figure 1 Slit lamp image of a mass lesion at the patientrsquos left eye caruncle for one month
Figure 2 One month after the first excision a protruding mass recurred at the patientrsquos nasal canthus
of left eye It partially involved beyond the gray line of nasal part lower eyelid
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
117
Figure 3 Histomorphology analysis and immunohistochemistry study of the caruncular lesion Abun-
dant atypical lymphoid proliferation presented in low-power photomicrograph (A) and
high-power photomicrograph (B) under hematoxylin-eosin staining The lymphoid aggrega-
tion was composed predominantly of CD20-positive cells (C) and focal positive staining of
CD3 (D)
Figure 4 Non-contrast orbital computed tomography showed a lesion of soft tissue density at medial
canthus of left orbit without obvious nasolacrimal duct or bony invasion (A) Magnetic reso-
nance imaging with contrast showed strong enhancement at left medial canthus region (B)
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
118
Figure 5 The follow-up photo were taken at three months after the second excision showing no signs
of recurrence
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
119
Juvenile Caruncular Atypical Lymphoid Proliferation ndash A Rare Case Report
罕見病例報告mdash青少年之淚阜非典型淋巴增生
施驊瑋 1林友祺 1
中文摘要
淚阜病灶相當罕見大部分為良性病灶眼睛及附屬結構淋巴增生疾病為其
鑑別診斷之一非常少見於年輕人或兒童我們報告一位 16歲的健康男性因
左眼淚阜無痛性腫塊接受切除手術卻於術後一個月復發執行第二次切除手術
後門診追蹤十個月未再復發此案例表現了部分良性與部分惡性腫瘤的特徵
我們針對反應性淋巴增生眼睛及附屬結構淋巴癌兩個疾病做討論及文獻回顧
關鍵字淚阜病灶眼睛及附屬結構淋巴增生疾病眼睛及附屬結構淋巴癌反
應性淋巴增生非典型淋巴增生
1 新光吳火獅紀念醫院眼科
通訊作者林友祺 電子信箱 yuchi067gmailcom
Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh 120
Submitted March 26 2020
Final version accepted April 16
2020
Case Report
Hyperacute intramembranous hemor-
rhage after burr hole craniostomy for
chronic subdural hematoma
Cite as Meng-Chi Lin Jui-Ming
Sun Yu-Hao Chen Cheng-Ta
Hsieh
Hyperacute intramembranous
hemorrhage after burr hole crani-
ostomy for chronic subdural he-
matoma Fu-Jen Journal of Medi-
cine 3(4) 120-125 2020
DOI
103966181020932020091803004
Meng-Chi Lin1 Jui-Ming Sun23 Yu-Hao Chen24 Cheng-Ta
Hsieh567
1Department of Surgery Zuoying Branch Kaohsiung Armed Forces
General Hospital Kaohsiung 813 Taiwan 2Section of Neurosurgery Department of Surgery Chia-Yi Christian
Hospital Chia-Yi City 600 Taiwan 3Department of Biotechnology Asia University Taichung City 41354
Taiwan 4Chung-Jen Junior College of Nursing Health Sciences and Manage-
ment Chia-Yi Country 62241 Taiwan 5Division of Neurosurgery Department of Surgery Sijhih Cathay Gen-
eral Hospital New Taipei City 22174 Taiwan 6Department of Medicine School of Medicine Fu Jen Catholic Univer-
sity New Taipei City 24205 Taiwan 7Department of Neurological Surgery Tri-Service General Hospital
National Defense Medical Center Taipei 114 Taiwan
Corresponding author E-mail address
nogormail2000comtw (Cheng-Ta Hsieh)
ABSTRACT
Burr hole craniostomy with closed-system drainage is an effective and common neurosurgical procedure to manage chronic subdural hematoma Postoperative hem-orrhage a well-known but infrequent complication may result in increased neurolog-ical deficits However hyperacute intramembranous hemorrhage within the inner and outer membrane of hematoma after burr hole craniostomy with irrigation and closed-system drainage has not been described previously Herein we report a case of postoperative spontaneous hyperacute intramembranous hemorrhage after burr hole craniostomy with closed-system drainage to manage a chronic subdural hematoma we subsequently discuss the possible pathophysiological mechanisms and review the relevant literature
Keywords Chronic subdural hematoma acute subdural hematoma bleeding burr hole craniostomy
drainage
Fu-J
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Vol 3 No 4 2
Acute intram
Yu-Hao Chen
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outer and ievidence suggwith or wite and widely ut and that it ] Recurrence r this surgerywever the hyng after burr ely been discucase of a pa
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gure 3) No aface was obseealed an organn of fibroblasne Postoperaogical deficits
ISCUSSIO61-year-old won without regd been takingning Ganodermrs She was tment when shurological exasgow Coma S
muscle strengs was 45 on
ale Her laborh the normal rnoted Brain
n revealed Ch a marked m
ently she receniostomy withinage ring surgery mthe subdural sn of the duramatoma The arile saline throsed drainage swever this inm the subduraealed a hyperdural space fniostomy siteniotomy withthe hematom
morrhage was d inner membgure 3) No aface was obseealed an organn of fibroblasne Postoperaogical deficits
EFERENCRohde VComplicatiand closedsubdural analysis of
active bleedinerved Histolonized hematots and capilla
ative recoverywas gradual a
ON oman had a hi
gular medicatig nutritional ma lucidum referred to ohe became proxamination rScale ratings wgth score in th
the Medical ratory examinranges with nn computed
CSDH in the midline shift (ived one righth irrigation a
motor oilndashlikespace was uncal and outer marea was irrigaough the subdusystem was plcreased the rel space An emracute hemorrfrom the frone (Figure 2B
membranectma was perfo
only observebrane of theactive bleedinerved Histolonized hematots and capilla
ative recoverywas gradual a
CES V Graf Gons of burr-
d-system draihematomas
f 376 patient
ng from the ogical examinoma with prolaries in the m
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history of hypeion treatmentsupplements for more tha
our emergencyogressively drrevealed thatwere E1M5V2he left side ex
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(Figure 1) St parietal burrand closed-sy
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y of previous and favorable
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Vol 3 No 4 2
Acute intram
Yu-Hao Chen
vealing a layer
displaying a m
quent CT scan
em drainage (
rhage in the ri
2020
membranous
Cheng-Ta Hs
red type of CS
midline shift
ns (A) Bone w
(white arrow)
ight frontal re
hemorrhage
ieh
SDH (white ar
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and (B) Soft
gion (white ar
rrow) in the rig
showed the b
tissue windo
rrow)
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burr hole crani
ow showed hy
123
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Fu-J
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of Medicine V
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Vol 3 No 4 2
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Yu-Hao Chen
o revealing ac
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cute intramem
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124
mem-
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Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh
125
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
慢性硬腦膜下出血進行鑽顱引流手術造成超急性夾膜內出
血
林孟楫 1孫瑞明 23陳昱豪 24謝政達 567
中文摘要
鑽顱併封閉系統引流手術是治療慢性硬腦膜下出血患者一種有效且常見的
神經外科手術方式術後出血可能導致神經功能缺損惡化是眾所周知但不常見
的併發症之一然而至今仍未有鑽孔併封閉系統引流造成原本慢性硬腦膜血
塊內膜和外膜間急性夾膜間出血案例在這裡我們報告一例慢性硬腦膜下出
血病患者接受鑽顱併封閉系統引流手術治療造成術後急性夾膜間出血我們在
本文中討論可能的致病機制並回顧相關文獻
關鍵字慢性硬腦膜下出血急性硬腦膜下出血出血鑽顱術引流
1國軍高雄總醫院左營分院 外科部
2崇仁醫護管理專科學校
3亞洲大學 生物科技學系
4戴德森醫療財團法人嘉義基督教醫院 外科部 神經外科
5汐止國泰綜合醫院 神經外科
6輔仁大學 醫學系
7 國防醫學院 三軍總醫院 神經外科
通訊作者謝政達 電子信箱 nogormail2000comtw
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
126
Submitted January 21 2020
Final version accepted July 08
2020
Case Report
Hamartoma of the breast A case report
Cite as Hsuan-An Chen
Cheng-Yu Lo Shih-Hung Huang
Chin-Lung Lin
Hamartoma of the breast A case
report Fu-Jen Journal of Medicine
3(5) 126-130 2020
DOI
103966181020932020091803005
Hsuan-An Chen1 Cheng-Yu Lo
3 Shih-Hung Huang
3 Chin-Lung
Lin2
1Department of Surgery Cathay General Hospital Taipei Taiwan
2Department of General Surgery Cathay General Hospital Taipei Tai-
wan
3Department of Pathology Cathay General Hospital Taipei Taiwan
Corresponding author E-mail address
lungyungmailcom (Chin-Lung Lin)
ABSTRACT
Breast hamartoma is an uncommon benign tumor rarely associated with malignancy An
excision and histological examination is necessary for the differential diagnosis We report
a case of a 49-year-old female patient presenting with a lump in the right breast Ultrasound
examination which demonstrated a 4411 cm hypoechoic lesion with lipoma Partial mas-
tectomy was arranged and the diagnosis of a hamartoma was confirmed by the histological
examination
Keywords Breast tumor Hamartoma Ultrasound
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
127
INTRODUCTION The hamartoma is a benign tumor-like lesion
that can affect various organs of the body in-
cluding lungs kidneys skin and more rarely the
breast In 1981 the hamartomas were recognized
in the WHO classification[1] They are defined
as well-demarcated mass of mammary ducts and
lobules containing varying amounts of fibrous
and adipose tissue and producing a distinctive
mammographic image
CASE REPORT A 49 year-old female had past history of left
breast mastitis with abscess status post partial
mastectomy This time she presented to our out
patient clinic for breast examination Physical
examination revealed a painless palpable mova-
ble and painless lump at upper outer quadrant of
right breast The risk of breast cancer was not
noted and the patient did not have any family
history of breast cancer The patient also denied
any trauma history before Ultrasound examina-
tion was arranged which demonstrated a 4411
cm hypoechoic lesion with lipoma at 3 oclock 2
cm from nipple of right breast and multiple hy-
poechoic nodules of various size in both breasts
and there was no suspicious axillary lymph
nodes noted (Figure1) Surgical treatment was
arranged partial mastectomy of right breast
harmartoma was successfully performed A 32 x
31 x 21 cm tumor was completely excised
Grossly examination showed a gray to yellow
and firm to fatty The diagnosis of a hamartoma
was confirmed by the histological examination
Microscopically sections of the breast lesion
show mammary hamartoma composed of ducts
lobules with interlobular fibrous tissue and adi-
pose tissue Fibrocystic change apocrine meta-
plastic ducts and scattered foci of adenosis are
noted The overall lobulocentric architecture and
the 2-cell pattern of the epithelium are preserved
columnar cell change and focal microcalcifica-
tion are present (Figure2) Based on submitted
biopsy specimen in-situ or invasive tumor cells
are not identified
DISCUSSION Hamartoma of the breast is a benign tumor like
nodule it was also known as fibroadenolipoma
lipofibroadenoma or adenolipoma based on its
predominant components It was composed of
varying amounts of glandular adipose and fi-
brous tissue[2] Hamartomas were first described
in 1971 by Arrigoni et al in a study of 10 patients
which breast tumors clinically and grossly re-
sembled fibroadenomas[3]
A higher predominance of tumors exists in fe-
males compared with males Hamartomas are
slowly-growing lesions with the diameter rang-
ing from 2 cm to 5 cm sometimes hamartomas
can reach giant diameter [4]
The clinical diagnosis of hamartoma is based on
the findings from mammography sonography
and histology examinations The hamartomas are
usually incidentally diagnosed by the women
older than 40 year-old starting mammography
screening
On physicial examination harmatomas are usu-
ally occult painless they may be as large mo-
bile soft to firm masses[5] Ultrasound showed
well capsulated mass with echogenic rim and
internal heterogeneity Mammography exam
showed well-circumscribed round to oval
masses containing fat and soft tissue densities
with a thin radiopaque pseudocapsule The
pseudocapsule results from displacement of
breast parenchyma by the tumor [56] In Pa-
thology finding microglandular adenosis is pre-
sent in fibroadipose stroma surrounded by a thin
fibrous capsule It composed of a combination of
epithelial and stromal elements usually with
normal ducts or lobules although variations of
normal tissue may also be seen Fibroadenoli-
poma myoid hamartoma and chondrolipoma are
histological variations of hamartomas depend-
ing on the proportion of normal breast tissue
elements[7]
Malignancy associated with hamartomas are
very rare[8] However it has been reported
hamartomas develop into carcinoma Malignant
transformation can occur as a result of cellular
atypia in the epithelial component of the mass[9]
Surgical removal is the curative method for
breast hamartomas[10] Diagnostic material such
as mammography ultrasonography or core nee-
dle biopsy may not give the definitive diagnosis
Therefore surgical excision and histological
examination is necessary for differential diagno-
sis[111213]
Although it is rare hamartoma can be seen along
with malignancy as it is formed from similar
components of breast tissue Therefore careful
diagnosis and appropriate management including
surgery are required
REFERENCES 1 World Health Organization (1981)
Histological typing of breast tumors In
International histological classification of
tumors 1981 2nd ed
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
128
2 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11435ndash449
2006
3 ArrigoniMG DockertyMB JuddES
The identificationand treatment of
mammary hamartoma Surg Gynecol
Obstet1971 133 577-82
4 Sanal HT Ersoz N Altinel O Unal E Can
C Giant hamartoma of the breast Breast J
2006 12 84-85
5 Feder JM de Paredes ES Hogge JP
Wilken JJ Unusual breast lesions
radiologic-pathologic correlation
Radiographics 1999 19S11ndashS26
6 Murat A Ozdemir H Yildirim H Poyraz
AK Ozercan R Hamartoma of the breast
Australas Radiol 200751 Spec NoB37ndash
9
7 Fisher CJ Hanby AM Robinson L Millis
RR Mammary hamartoma-a review of 35
cases Histopathology 1992 20 99-106
8 Choi N Ko ES Invasive ductal carcinoma
in a mammary hamartoma case report and
review of the literature Korean J Radiol
2010 Nov-Dec11(6)687-91
9 Lee EH Wylie EJ Bourke AG Bastiaan
De Boer W Invasive ductal carcinoma
arising in a breast hamartoma two case
reports and a review of the literature Clin
Radiol 2003 58 80-3
10 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11 435 ‑449
2006
11 Coyne J Hobbs FM Boggis C Harland R
Lobular carcinoma in a mammary
hamartoma J Clin Pathol 199245936ndash
937
12 G M K Tse B K B Law T K F Ma A B W
Chan Hamartoma of the breast a
clinicopathological review J Clin Pathol
200255951ndash954
13 RAAmir SSheikh BreasthamartomaA
report of 14cases of an under-recognized
and under-reported entity International
Journal of Surgery Case Reports
22(2016)1ndash4
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
129
FIGURES
Figure 1 Ultrasound shows a 4411 cm hypoechoic lesion with lipoma at 3 oclock 2 cm from nipple
of right breast
Figure 2 Photomicrograph shows mammary hamartoma composed of ducts lobules with interlobular
fibrous tissue and adipose tissue
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
130
Hamartoma of the breast A case report
乳房錯構瘤罕見個案報告
陳宣安 1羅承裕 3黃世鴻 3林錦龍 2
中文摘要
乳房錯構瘤是一種罕見之乳房良性腫瘤切除手術及病理化驗來做鑑別診斷
我們報告一位 49歲女性以可觸摸到無痛性右側乳房腫塊為臨床表徵超音波
看到一個邊緣清楚低迴音的腫塊病患接受手術切除病灶病理診斷證實為乳
房錯構瘤
關鍵字乳房腫瘤錯構瘤超音波攝影
1國泰綜合醫院外科部
2國泰綜合醫院一般外科
3國泰綜合醫院病理科
通訊作者林錦龍 電子信箱 lungyungmailcom
Fu-Jen Journal of Medicine
Mission and Goals
The Fu-Jen Journal of Medicine (FJJM) is a peer-reviewed journal which
aims to enhance research quality of staffs in the College of Medicine Fu Jen
Catholic University The journal publishes original investigations across a
wide range of medical disciplines including original research articles in basic
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September 30 2020
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- 9月封面
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創心
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1新北
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通訊
Jen Journal o
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Compariso
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of Medicine V
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Vol 3 No 1 2
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2020
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共有 53 名病
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尼組
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Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang
99
Submitted October 11 2019
Final version accepted February
02 2020
Original Research Article
Human Factors Underlying Adverse
Medical Events Revisit Root Cause Anal-
ysis Cases Using the HFACS
Cite as Yu-Hsun Cheng
Sheng-Hui Hung Tung-Wen Ko
Pa-Chun Wang
Human Factors Underlying Ad-
verse Medical Events Revisit
Root Cause Analysis Cases Using
the HFACS Fu-Jen Journal of
Medicine 3(2) 99-111 2020
DOI
103966181020932020091803002
Yu-Hsun Cheng1 Sheng-Hui Hung
12 Tung-Wen Ko
3 Pa-Chun
Wang14
1Department of Quality Management Cathay General Hospital Taipei
Taiwan
2Institute of Health Policy and Management National Taiwan Universi-
ty Taipei Taiwan
3Center for Healthcare Quality Management Cheng Hsin General Hos-
pital Taipei Taiwan
4Fu Jen Catholic University School of Medicine New Taipei City Tai-
wan
Corresponding author E-mail address
drtonyseednettw (Pa-Chun Wang)
ABSTRACT Background Appropriate management of adverse medical events (AMEs) is the corner-
stone of patient safety Root cause analysis (RCA) is used to investigate serious or
high-frequency errors but is limited by its inability to explain a broader scope of factors
We re-reviewed RCA cases to understand the underlying human organizational or system-
ic factors affecting AMEs Methods A total of 40 consecutive RCA cases (2012-2016) were
retrieved from the AMEs database A panel was organized to retrospectively re-review these
cases using the Human Factor Analysis and Classification System HFACS Results For
active failures errors stemmed largely from performance-based (95) judgment and deci-
sion-making errors (875) Incorrectly followed procedures (816) and accidental
equipment operation (50) were the most common types of performance-based errors In-
adequate real-time assessment (686) and inappropriate operative actions (686) were
the most common decision-making errors For sources of latent failure teamwork problems
(275) including failure to effectively communicate (818) and communicate critical
information (727) were common Inadequate supervision (929) or command over-
sights (929) were the most common problems related to inadequate supervision (35)
Organizational programpolicy risks not adequately assessed (50) were the most common
problems related to policy and process problem (25) Conclusions The HFACS review
enhances our understanding of human factors underlying AMEs The HFACS reveals latent
supervisory organizational or systematic problems that cannot be addressed through tradi-
tional RCA Keywords patient safety adverse events root cause analysis human factors
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 100
INTRODUCTION Patient safety involves the reduction of patient
harm from potentially avoidable unintended
outcomes [1] Studies have revealed that 50ndash
80 of adverse medical events (AMEs) are pre-
ventable [2-4] to eliminate such errors the ap-
propriate management of AMEs hence repre-
sents the cornerstone of patient safety work
Through incident reporting investigation and
analysis healthcare providers can correct or
re-engineer their care processes to prevent inci-
dent recurrence [25] One of the most popular
tools for investigating AMEs is root cause anal-
ysis (RCA) RCA reconstructs a chain of errors
to identify the deviation of care from normal
processes Nonetheless with a lack of standard-
ized nomenclature and investigation procedures
RCA report conclusions are sometimes too sub-
jective and nonspecific to facilitate any actiona-
ble safety improvement plans [5-7] According
to the UK Health and Safety Executive defini-
tion human factors are environmental organiza-
tional occupational or individual human char-
acteristics which influence behavior at work
such that health and safety are affected [8] Hu-
mans and systems are prone to errors and stud-
ies have showed that nearly 70 of medical
errors involve human factors [2-4] Reasonrsquos
Swiss cheese model described the penetration of
causative human errors through layers of defen-
sive barriers leading to system collapse [9]
With much focus on the temporal sequence and
severity of departure from accepted practices in
an incident the effectiveness of RCA is often
challenged by its incapability of exploring un-
derlying human organization or even systemic
factors [5-7] Reason and others have proposed
that errors can occur at 4 levels 1) unsafe acts
(operator actions) 2) preconditions for unsafe
acts (environmental factors contributing to er-
rors) 3) inadequate supervision (management
actions affecting the operator) and 4) organiza-
tional influences (organizational culture policies
and procedures that affect the operator) [9]
Based on this theory Wiegmann and Shappell
developed the Human Factor Analysis Classifi-
cation System (HFACS) to describe human fac-
tors causing accidents from 4 tiers of categories
Each of these categories consists of nanocodes to
represent specific human behavior or system
problems leading to errors [9-10] The tier for
unsafe acts involves actual provider actions (er-
rors or rule violations) directly leading to events
The tier representing preconditions for unsafe
acts includes operational personnel and envi-
ronmental factors The supervision tier addresses
leadership problems operational planning fail-
ure or correction and supervisory ethics The
tier for organizational influences deals with re-
source management organizational climate and
operational processes (Supplement Table 1) The
HFACS provides standardized investigation
processes for the systematic analysis of common
causes of adverse events across national defense
nuclear power navy aviation and healthcare
industries Taiwan launched its nationwide
AME-reporting system the Taiwan Patient
Safety Reporting System (TPR) in 2004 RCA
methodology was subsequently introduced to the
healthcare industry by the Joint Commission of
Taiwan [11] Since 2012 appropriate manage-
ment of AMEs has been listed as a national pa-
tient safety goal [12] RCA is required by the
Ministry of Health and Welfare for major AMEs
Aside from RCA a comprehensive structural
reliable and valid framework is urgently re-
quired to further guide organizational or even
national patient safety policies In this study we
used the HFACS to review our RCA cases aim-
ing to investigate human factors underlying se-
vere or frequent AMEs
MATERIALS AND METHODS Through continuous sampling 40 consecutive
RCA cases (2012-2016) were retrieved from a
hospitalrsquos (Cathay General Hospital Taipei
Taiwan) AME-reporting system database The
database contains AMEs relating to areas such as
medication patient falls surgery transfusion
clinical care public accidents security hospital
violence tube-related complication unplanned
cardiopulmonary resuscitation laboratory testing
and examination and anesthesia The RCA cases
were sentinel or high-frequency events classified
according to severity assessment category (SAC)
[1113] The SAC is an evaluation method for
categorizing AMEs by severity of effect on pa-
tients health and risk of incident reoccurrence
The HFACS has been modified (from the US
Department of Defense version 70) and trans-
lated into Mandarin Chinese with authorization
from the original developers [10] The Chi-
nese-version HFACS for Taiwan is a valid in-
strument (content validity index 09 Cronbachrsquos
α gt07 interrater reliability Κ 04-10) equiva-
lent to the original English version [9] The
HFACS contains 4 tiers 13 subitems and 109
nanocodes (Supplement Table 1) A panel of 6
reviewers was established All reviewers were
from clinical or management (quality and patient
safety management) backgrounds Reviewers all
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 101
finished human factor education and were
trained to use the HFACS through a consensus
meeting Each RCA case was randomly assigned
to 2 reviewers Human factors leading to partic-
ular AMEs were identified and confirmed when
2 reviewers reached agreement The distribution
of errors among tiers subitems and nanocodes
are provided with descriptive statistics () The
study was approved by the Institutional Review
Board of Cathay General Hospital
(CGH-P105095)
RESULTS AMEs related to laboratory testing and examina-
tion (n = 16) clinical care (n = 9) and medica-
tion (n = 7) were the most commonly observed
in the RCA Most AMEs in this cohort are
ranked as being SAC level 3 (n = 15) or 4 (n =
17) (Table 1)
Acts (Active Failures)
This tier of errors contains 3 subitems and 13
nanocodes In the 40 RCA cases perfor-
mance-based errors for 38 (95) and judgment
and decision-making errors for 35 (875) com-
prised the most common error types with viola-
tion for 6 (15) less common Procedure fol-
lowed incorrectly for 31 out of 38 (816) was
the most common performance-based problem
Inadequate real-time risk management for 24 out
of 35 (686) was the most common judgment
or decision error All of the rule violations were
workaround types for 6 out of 6 (100) (Figure
1)
Preconditions(Latent Failures)
This tier of errors has 9 subitems and 58 nano-
codes In the 40 RCA cases teamwork for 11
(275) and environmental for 8 (20) factors
contributed to most of the errors with mental
and physical state the next most common factor
for 7 (175) Communication for 9 out of 11
(818) and information relay for 8 out of 11
(727) were the most common issues related to
teamwork Few contributors mentioned failures
related to technical errors for 4 (50) or physi-
cal for 1 (125) environment Not paying at-
tention for 4 out of 7 (571) and negative habit
transfer for 4 out of 7 (571) were common
mental contributes noted for 7 (100) Overcon-
fidence was the most common problem related
to emotional status for 4 out of 7 (571) Fa-
tigue was observed in only 2 cases for 2 out of 2
physical problems (100) (Figure 2)
Supervision(Direct Supervisory Chain of
Command)
This tier of errors contains 3 subitems and 17
nanocodes In the 40 RCA cases inadequate
supervision for 14 (35) and inappropriately
planned operations for 11 (275) factors con-
tributed to most of the respective errors fol-
lowed by supervisory violations for 7 (175)
Supervisory or command oversights for 13 out
of 14 (929) were the most common sources of
supervision inadequacy Authorized unnecessary
hazards for 7 out of 11 (636) were the most
common inappropriately planned operations
Failure to enforce rules for 6 out of 7 (857)
was the most common supervisory violation
(Figure 3)
Organization Influence (Upper-Level Man-
agement)
This tier of errors contains 4 subitems and 18
nanocodes In the 40 RCA cases policy and
process issues for 10 (25) and resources prob-
lem for 8 (20) were major concerns Few of
the respective problems are related to climate
and cultural influences for 2 (5) or to person-
nel selection and staffing for 1 (25) Poorly
assessed organizational programs or policy risks
for 5 out of 10 (50) were the most common
policy and process problems Failure to provide
adequate operational information resources for 4
out of 8 (50) and command and control re-
source deficiency for 3 out of 8 (375) were
the main resource management problems Little
was revealed regarding organizational climate
and culture (n = 1 out of 2 50) or staffing for 1
out of 1 (100) (Figure 4)
DISCUSSION Health care is a complex system comprising
many high-reliability organizations (HROs) The
vulnerability of HROs stems from the participa-
tion of multidisciplinary teams in the processes
along a variety of patient care timelines How-
ever humans and systems are inherently prone
to errors the appropriate management of AMEs
is acknowledged to be the cornerstone of patient
safety AMEs should be reported investigated
analyzed and handled appropriately[14] Theo-
retically by analyzing the pattern of key defects
providers can fix errors and re-engineer their
care processes to reduce the possibility of AME
recurrence Taiwan established its nationwide
TPR in 2004 so far 7000 health care facilities
have participated and the database has accumu-
lated more than 055 million AMEs[11] Infor-
mation generated from the TPR database can
improve patient safety at individual organiza-
tional or even national levels However despite
relentless efforts few substantial improvements
have been achieved in patient safety [15-17]
Since its introduction in Taiwan in 2006 the use
of RCA for AMEs has encountered some diffi-
culties 1) No structural and standardized
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 102
framework exists for investigation
cross-institution variability and interrater relia-
bility are often ignored 2) Conclusions are often
subjective and corrective recommendations are
less actionable relying on individual reviewersrsquo
professional backgrounds and their experiences
3) Much focus on event reconstruction and oper-
ator performance means that factors relating to
human behavior organizational culture and
system weakness are not comprehensively ad-
dressed [671718] Traditionally attempts to
improve patient safety in the health care industry
are largely reactive in nature identifying and
correcting errors in care processes [1920]
Causes of defects are not thoroughly understood
Proactive approaches must be taken to address
systematic problems within a complex system
[720] Research suggests that human error is a
causal factor in the occurrence of AMEs AME
investigation targets have moved from skill defi-
ciency toward decision-making attitudes super-
visory factors and even organizational climate
or culture HFACS methodology is based on the
Swiss cheese model that also emphasizes active
and latent failures [921] The study provides
some noteworthy findings First most AMEs as
expected involve active failures such as failure
to follow procedure accidental operation of
equipment inadequate real-time risk manage-
ment and inappropriate action These are all
sharp ends in classic RCA environment physi-
cal and mental factors are less prevalent This
proves that retrospectively determining addi-
tional causal factors is difficult when infor-
mation has not been collected during preliminary
investigation (Figure 1) Second team-
work-related problems particularly in relation to
communication and information relay are well
addressed This may be attributed to the dec-
ade-long institution-wide routine crew resource
management training in the respective research
hospital (Figure 2) Third the HFACS success-
fully reflects the importance of supervisory roles
in the occurrence of AMEs and this cannot be
overlooked (Figure 3) Fourth latent failures
especially in organizational climate or cultural
dimensions have been less frequently addressed
in incident reports a limitation of traditional
RCA However the HFACS review suggests
room for improvement in resource allocation and
policy modification within the hospital The
results of studies can make the organization
think about how to improve the patient safety
and management process from the perspective of
human factors such as improving the comfort of
the working environment and replacing and
equipment resources to prevent personnel from
affecting the medical quality and patient safety
due to the environment or equipment Need to
appropriate assessment of applicability and ade-
quate training of manpower is required The
management and control of risks should be fully
evaluate and grasp resource management and
leaders need to participate in and promote medi-
cal quality and patient safety activities to en-
hance its culture (Figure 4) No panacea exists
to ensure patient safety and improvement targets
originate largely from event investigation find-
ings Unfortunately factors identified from
AMEs are often self-explanatory with little value
for further action correction Reinforcement of
policy or processes redundant education or
repetitious training are formulaic overprescribed
RCA recommendations The use of HFACS in
this study proves that a structural prospective
AME investigation format can potentially help
with proactive patient safety management We
suggest developing an interview guideline for
the routine use of HFACS as a complement to
RCA in every AME investigation This study is a
retrospective study The underlying human fac-
tors can be under-estimated owing to the lack of
related information in the original RCA reports
CONCLUSION The HFACS review in this study enhances our
understanding of human factors in AMEs that
had previously been insufficiently scrutinized
Aside from active process and communication
errors the HFACS enables the prospective in-
vestigation of latent supervisory organizational
or systematic problems that cannot be addressed
through traditional RCA
REFERENCES 1 T Brennan L Leape N Laird et al
Incidence of adverse events and
negligence in hospitalized patients results
of the Harvard Medical Practice Study I N
Engl J Med 1991324370-376
2 Wang CH Shih CL Chen WJ et al
Epidemiology of medical adverse events
perspectives from a single institute in
Taiwan J Formos Med Assoc
2016115434-439
3 Vincent C Simon R Sutcliffe K et al
Errors Conference Executive Summary
Acad Emerg Med 200071180-1182
4 Taitz J Genn K Brooks V et al
System-wide learning from root cause
analysis A report from the New South
Wales Root Cause Analysis Review
Committee Qual Saf Health Care
2010191-5
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 103
5 Hutchinson A Young TA Cooper KL et
al Trends in healthcare incident reporting
and relationship to safety and quality data
in acute hospitals results from the
National Reporting and Learning System
Qual Saf Health Care 2009185-10
6 Mitchell RJ Williamson AM Molesworth
B et al A review of the use of human
factors classification frameworks that
identify causal factors for adverse events
in the hospital setting Ergonomics
2014571443-1472
7 Gurses AP Ozok AA Pronovost PJ Time
to accelerate integration of human factors
and ergonomics in patient safety BMJ
Qual Saf 201221347-351
8 Health and Safety Executive Introduction
to human factors
httpwwwhsegovukhumanfactorsintro
ductionhtm
9 Wiegmann DA Shappell SA A human
error approach to aviation accident
analysis The human factors analysis and
classification system Burlington VT
Ashgate Publishing Ltd 2003
10 Yu-Hsun Cheng Sheng-Hui Hung
Tung-Wen Ko et al An Analysis of the
Reliability and Validity of Human Factors
Analysis Classification System in Medical
Adverse Events Journal of Healthcare
Quality 20191370-76
11 Taiwan Joint Commission on Hospital
Accreditation Taiwan Patient-Safety
Reporting System Annual Report 2017
New Taipei City Taiwan
12 Taiwan Patient Safety Net
httpwwwpatientsafetymohwgovtwCo
ntentzMessagesslistaspxSiteID=1ampMm
mID=621273300317401756
13 Government of Western Australia
Department of Health
httpsww2healthwagovauArticlesS_T
Severity-assessment-codes
14 Farley DO Haviland A Champagne S et
al Adverse-event-reporting practices by
US hospitals results of a national survey
Qual Saf Health Care 200817416-423
15 Shojania KG Thomas EJ Trends in
adverse events over time why are we not
improving BMJ Qual Saf
201322273-277
16 Levitt P Challenging the systems approach
why adverse event rates are not improving
BMJ Qual Saf 2014231051-1052
17 Kellogg KM Hettinger Z Shah M et al
Our current approach to root cause
analysis is it contributing to our failure to
improve patient safety BMJ Qual Saf
201726381-387
18 Khorsandi M Skouras C Beatson K et al
Quality review of an adverse incident
reporting system and root cause analysis of
serious adverse surgical incidents in a
teaching hospital of Scotland Patient Saf
Surg 2012621
19 Diller T Helmrich G Dunning S et al
The Human Factors Analysis
Classification System (HFACS) Applied to
Health Care Am J Med Qual
201429181-190
20 Carayon P Xie A Kianfar S Human
factors and ergonomics as a patient safety
practice BMJ Qual Saf 201423196-205
21 Reason J Human Error New York
Cambridge University Press 1990
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 104
TABLE
Table 1 Incidences by Category (N=40)
CategorySAC SAC 4 SAC 3 SAC 2 SAC 1 total
Laboratory and ex-
amination events
4 10 2 0 16 (400)
Clinical care event 6 2 1 0 9 (225)
Medication event 5 0 2 0 7 (175)
Surgery-related event 1 1 2 0 4 (100)
Transfusion-related
event
1 1 0 0 2 (50)
Tube event 0 1 0 0 1 (25)
Public accident 0 0 1 0 1 (26)
Total 17 (425) 15 (375) 8 (200) 0 40 (100)
SAC 1113 Severity Assessment Code SAC
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 105
FIGURES
Figure 1 Active Failures (N=40)
16 (167)
66 (1000)
640 (150)
235 (57)
735 (200)
2435 (686)
2435 (686)
3540 (875)
438 (105)
438 (105)
738 (184)
1938 (500)
3138 (816)
3840 (950)
0 5 10 15 20 25 30 35 40
Commits WidespreadRoutine Violation
Performs Work-Around Violation
Ignored a CautionWarning
Failure to Prioritize Tasks Adequately
Wrong Choice of Action During an Operation
Inadequate Real‐Time Risk Assessment
Rushed or Delayed a Necessary Action
Breakdown in Visual Scan
Over-ControlledUnder-Controlled AircraftVehicleSystem
Unintended Operation of Equipment
Procedure Not Followed Correctly
Performance-Based Errors
Judgment and Decision Making Errors
Violations
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 106
Figure 2 Preconditions (Latent Failures or Conditions) (N=40)
14 (250)
24 (500)
48 (500)
11 (1000)
18 (125)
840 (200)
0 5 10 15 20 25 30 35 40
Seat and Restraint System Problems
Instrumentation amp Warning System Issues
Noise Interference
Environment
Physical Environment
Technological Environment
27 (286)
27 (286)
27 (286)
37 (129)
47 (511)
47 (571)
77 (1000)
24 (500)
44 (1000)
47 (571)
12 (500)
22 (1000)
27 (286)
740 (175)
0 5 10 15 20 25 30 35 40
Technical or Procedural Knowledge Not Retained After Training
InterferenceInterruption
Task OverUnder Saturation
Distraction
Negative Habit Transfer
Not Paying Attention
Complacency
Overconfidence
Physical IllnessInjury
Fatigue
Physical and Mental State
Physical Problem
State of Mind
Mental Awareness
211 (182)
311 (273)
311 (273)
411 (364)
811 (7227)
911 (818)
1140 (275)
0 5 10 15 20 25 30 35 40
Inadequate Task Delegation
TaskMission PlanningBriefingDebriefing Inadequate
Failure of CrewTeam Leadership
StandardProper Terminology Not Used
Critical Information Not Communicated
Failed to Effectively Communicate
Teamwork
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 107
Figure 3 Supervision (Direct Supervisory Chain of Command) (N=40)
Figure 4 Organization Influence (Upper-Level Management Command Level) (N=40)
114 (71)
114 (71)
214 (143)
314 (214)
1314 (929)
1440 (350)
511 (455)
511 (455)
711 (636)
1140 (275)
47 (571)
67 (857)
740 (175)
0 5 10 15 20 25 30 35 40
Selected Individual with Lack of Proficiency
Improper Role‐modeling
Failed to Provide Proper Training
Failed to IdentifyCorrect Risky or Unsafe Practices
SupervisoryCommand Oversight Inadequate
Performed Inadequate Risk Assessment ‐Formal
Selected Individual with Lack of Current or Limited Experience
Authorized Unnecessary Hazard
Allowing Unwritten Policies to Become Standard
Failure to Enforce Existing Rules
Supervisory Violations
Planned Inappropriate Operations
Inadequate Supervision
12 (500)
12 (500)
240 (50)
110 (100)
510 (500)
1040 (250)
11 (1000)
140 (25)
18 (125)
18 (125)
38 (35)
48 (500)
840 (200)
0 5 10 15 20 25 30 35 40
Organizational Over-confidence or Under-confidence in Equipment
Organizational Culture (attitude actions) Allows for Unsafe TaskMission
Purchasing or Providing Poorly Designed or Unsuitable Equipment
Organizational ProgramPolicy Risks not Adequately Assessed
Failure to Provide Adequate Manning Staffing Resources
Failure to remove inadequate worn-out equipment in timely manner
Inadequate infrastructure
Command and control resources are deficient
Failure to provide adequate operational information resources
Resource Problems
Personnel Selection amp Staffing
Policy and Process Issues
ClimateCulture Influences
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 108
Supplement Table 1- HFACS Content of Human Factor Analysis Classifi-
cation System [9] Tier main level sub-item nano code
Tier 1 Unsafe Acts
Perfor-
mance-Based
Errors
Unintended operation of equipment
Checklist not followed correctly
Procedure not followed correctly
Over-controlledunder-controlled aircraftvehiclesystem
Breakdown in visual scan
Rushed or delayed a necessary action
Judgment amp De-
cision-Making
Errors
Inadequate real‐time risk assessment
Failure to prioritize tasks adequately
Ignored a cautionwarning
Wrong choice of action during an operation
Violations
Performs work-around violation
Commits widespreadroutine violation
Extreme violation-lack of discipline
Tier 2 Preconditions
Environment
Physical environment
Environmental conditions affecting vision
Vibration effects vision or balance
Heatcold stress impairs performance
External force of object impeded an individualrsquos
movement
Lights of other vehiclevesselaircraft affected vision
Noise interference
Technological environment
Seat and restraint system problems
Instrumentation amp warning system issues
Visibility restrictions (not weather related)
Controls and switches are inadequate
Automated system creates unsafe situation
Workspace incompatible with operation
Personal equipment interference
Communication equipment inadequate
Physical and
Mental State
Physical problem
Substance effects (alcohol supplements medications
drugs)
Loss of consciousness (sudden or prolonged onset)
Physical illnessinjury
Fatigue
Inadequate adaptation to darkness
Dehydration
Body sizemovement limitations
Physical strength amp coordination (inappropriate for
task demands)
Nutritiondiet
State of mind
Psychological problem
Life stressors
Emotional state
Personality style
Overconfidence
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 109
Pressing
Complacency
Motivation
Motivational exhaustion (burnout)
Sensory misperception
Motion illusion-kinesthetic
Turning illusionbalance-vestibular
Visual illusion
Misperception of changing environment
Misinterpreted misread instrument
Misinterpretation of auditorysound cues
Spatial disorientation
Temporaltime distortion
Mental awareness
Not paying attention
Fixation
Task overunder saturation
Confusion
Negative habit transfer
Distraction
Geographically lost
Interferenceinterruption
Technical or procedural knowledge not retained after
training
Inaccurate expectation
Teamwork
Failure of crewteam leadership
Inadequate task delegation
Rankposition intimidation
Lack of assertiveness
Critical information not communicated
Standardproper terminology not used
Failed to effectively communicate
Taskmission planningbriefingdebriefing inadequate
Tier 3 Supervision
Supervisory Vio-
lations
Failure to enforce existing rules
Allowing unwritten policies to become standard
Directed individual to violate existing regulations
Authorized unqualified individuals for task
Planned Inappro-
priate Operations
Directed task beyond personnel capabilities
Inappropriate team composition
Selected individual with lack of current or limited experience
Performed inadequate risk assessment ‐formal
Authorized unnecessary hazard
Inadequate Su-
pervision
Supervisorycommand oversight inadequate
Improper role‐modeling
Failed to provide proper training
Failed to provide appropriate policyguidance
Personality conflict with supervisor
Lack of supervisory responses to critical information
Failed to identifycorrect risky or unsafe practices
Selected individual with lack of proficiency
Tier 4 Organizational
Influences
Resource Prob-
lems
Command and control resources are deficient
Inadequate infrastructure
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 110
Failure to remove inadequate worn-out equipment in timely
manner
Failure to provide adequate operational information resources
Fail to provide adequate funding
Personnel Selec-
tion amp Staffing
Personnel recruiting amp selection policies are inadequate
Failure to provide adequate manning staffing resources
Policy amp Process
Issues
Pace of ops-tempoworkload
Organizational programpolicy risks not adequately assessed
Provided inadequate procedural guidance or publications
Organizational (formal) training is inadequate or unavailable
Flawed doctrinephilosophy
Inadequate program management
Purchasing or providing poorly designed or unsuitable equip-
ment
ClimateCulture
Influences
Organizational culture (attitude actions) allows for unsafe
taskmission
Organizational over-confidence or under-confidence in equip-
ment
Unit missionaircraftvehicleequipment change or unit deacti-
vation
Organizational structure is unclear or inadequate
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 111
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
以 HFACS重新檢視根本原因分析案例挖掘造成醫療不良
事件之人為因素
鄭伃洵 1洪聖惠 12柯彤文 3王拔群 14
中文摘要
背景醫療不良事件(AMEs)的管理是促進病人安全的基石根本原因分析
(RCA)是探討重大病人安全不良事件問題但是由於無法解釋更廣泛的因素而受
到限制本研究使用人為因素分類與分析工具(HFACS)回溯審視醫療不良事件
以了解影響醫療不良事件的人為因素及各層面中錯誤原因之分佈或系統性問題
方法本研究回溯 2012-2016年間有做過根本原因分析之醫療不良事件以連續
性取樣方式(continuous sampling)收集 40例醫療不良事件以人為因素分類與分
析工具(HFACS)去系統性的挖掘每件案例發生錯誤之原因結果在行為層面中
分析結果主要為基礎技能錯誤(95)判斷和決策錯誤(875)其中在基礎技能
錯誤當中以未依程序作業執行(816)及未如預期設備操作(50)佔多數判斷和
決策錯誤中以現場風險評估不確實(686)及採取錯的步驟行為(686)佔多數
而在先決條件層面中以團隊合作(275)為主要因素包含溝通不良(818)及重
要訊息未以正確的方式即時傳達(727)佔多數在監督層面當中以監督不周
(929)或監督不妥當(929)為主要因素在組織政策和流程方面(50)以組織
系統的政策風險未充分評估(35)為主要因素結論本研究進一步了解醫療不
良事件在過去使用根本原因分析未探討到的人為因素反映出潛在的監督組織
行為或系統性的問題促進病人安全預防錯誤再發生
關鍵字病人安全醫療不良事件根本原因分析人為因素
1國泰醫療財團法人國泰綜合醫院 品質管理部
2國立臺灣大學健康政策與管理研究所
3振興醫療財團法人振興醫院 醫療品質管理中心
4輔仁大學醫學院
通訊作者王拔群 電子信箱 drtonyseednettw
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin 112
Submitted January 20 2020
Final version accepted April13
2020
Case Report
Juvenile Caruncular Atypical Lymphoid
Proliferation ndash A Rare Case Report
Cite as Hua-Wei Shih Yu-Chi Lin
Juvenile Caruncular Atypical
Lymphoid Proliferation ndash A Rare
Case Report Fu-Jen Journal of
Medicine 3(3) 112-119 2020
DOI
103966181020932020091803003
Hua-Wei Shih1 Yu-Chi Lin
1
1Department of Ophthalmology Shin Kong Wu Ho-Su Memorial Hos-
pital Taipei City Taiwan
Corresponding author E-mail address
yuchi067gmailcom (Yu-Chi Lin)
ABSTRACT
Lesions of the caruncle are very rare Most caruncular lesions are benign though there were still few reported malignant lesions Ocular adnexal lymphoproliferative disease (OALD) one of the differential diagnosis of caruncular lesion is seldom seen in young pa-tient In this article we report a 16-year-old boy with recurrent caruncular atypical lym-phoid proliferation We discuss the epidemiology clinical features images histomorpholo-gy and treatment between ocular adnexal lymphomas (OAL) and reactive lymphoid hyper-plasia (RLH)
Keywords caruncular lesion ocular adnexal lymphoproliferative disease ocular adnexal lymphoma
reactive lymphoid hyperplasia atypical lymphoid proliferation
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
113
INTRODUCTION Lesions of the caruncle are very rare Differen-
tial diagnosis includes nevus myeloproliferative
disorders tumors inflammation infection cysts
vascular lesions and fibrous Biopsy is essential
for diagnosis Levy J et al reported ocular ad-
nexal lymphoproliferative disease (OALD) was
relatively uncommon diagnosis among caruncu-
lar lesions [1]
OALD was seldom described in Asian popula-
tion especially for young age C-Y Cheng re-
ported age-standardized incidence of ocular
adnexal lymphomas (OAL) in Taiwan from 1979
to 1996 was below 07 per million per year and
mean age was 531 years old [2] In 2015 five
Taiwanese cases of OAL whose age ranging
from 45 to 64 were presented [3] However
there were few cases of conjunctival OAL or
RLH in Chinese pediatric patient
Here we present a case of 16-year-old boy with a
caruncular mass at his left eye with recurrence
one month after excision We describe his clini-
cal symptoms photographs pathological results
management and follow-up clinical course in
this report
CASE REPORT A 16-year-old healthy boy presented a mass
lesion at his left eye caruncle accompanied with
the symptom of tearing for one month (Figure 1)
He had no ocular pain no itchiness no blurred
vision no night sweating no fever and no body
weight loss The patient denied systemic diseas-
es and histories of surgery His bilateral best
corrected visual acuity (BCVA) were 66 and
intraocular pressure (IOP) were both within
normal range There were no remarkable find-
ings for his cornea lens fundus and physical
examination Excision was performed and the
mass was soft with fluid inside therefore con-
junctival pyogenic cyst was our initial diagnosis
However one month after the excision a pro-
truding mass recurred at the patientrsquos nasal can-
thus of left eye (Figure 2) There were some
differences compared to previous condition At
the first time the soft mass was contained in a
well-defined cyst wall which more favored py-
ogenic granulation However after short period
of recurrence solid consistency and unclear
margin were found which favored malignancy
Besides the mass partially involved beyond the
gray line of nasal part lower eyelid whereas last
time the cyst mainly extended from conjunctiva
of caruncle The second excisional biopsy was
performed Pathologic examination demonstrat-
ed abundant atypical lymphoid proliferation
(Figure 3A 3B) Immunohistochemical studies
showed that the lymphoid aggregation was
composed predominantly of CD20-positive cells
(Figure 3C) focal positive staining of CD3
(Figure 3D) CD5 CD23 CD10 and negative
staining of cyclin-D1 Unfortunately the cellular
morphology was difficult to be evaluated due to
marked crushing artifact Thus malignant lym-
phoma cannot be excluded totally
Orbital computed tomography (CT) showed a
lesion of soft tissue density at medial canthus of
left orbit without obvious nasolacrimal duct or
bony invasion (Figure 4A) Magnetic resonance
imaging (MRI) with contrast showed strong
enhancement at left medial canthus region (Fig-
ure 4B) There was no remarkable finding in the
systemic workup including complete blood
count and differential count biochemical pro-
files and 18F-fluoro-2-deoxyglucose positron
emission tomographycomputed tomography
(18F-FDG PETCT) indicating no evidence of
systemic involvement
After the second excision we preferred con-
servative management for him due to the uncer-
tainty of malignancy and to avoid side effects
from aggressive treatment No sign of recurrence
was noted after 10 months of observation The
follow-up photo was taken at three months after
the second operation (Figure 5)
DISCUSSION Ocular adnexal lymphoproliferative disease
(OALD) consists of the spectrum of lymphoid
disease affecting the tissues surrounding the eye
including ocular adnexal lymphomas (OAL) and
lymphoid hyperplasia (LH) [4] The conjunctiva
is an important location for extranodal lympho-
ma development which comprises 25 of OAL
[5]
OAL can be grouped into two categories based
on their appearance of cells under the micro-
scope low-grade and high-grade [6] Extranodal
marginal zone lymphoma of mucosa-associated
lymphoid tissue (EMZLMALT) is the most
common subtype of OAL followed by follicular
lymphoma [7-9] Both of the above are
low-grade lymphomas
LH can be further divided by histopathology into
reactive lymphoid hyperplasia (RLH) and atypi-
cal lymphoid hyperplasia (ALH) RLH has to-
tally benign morphology and immunophenotype
whereas ALH has borderline lesions between
RLH and lymphoma [10] OAL and LH are
mostly seen in patients with age between 50-70
years old There are rare cases in pediatric group
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
114
[71011] In the C-Y Chengrsquos statistical report of
OAL in Taiwan only 8 patients were younger
than 15 years old among the 101 cases of ocular
lymphoma [2] According to an US study inci-
dence rates of OAL were analyzed in different
age groups the group of age over 50 had the
highest incidence rate of 574 per million per-
son-years while the 0-19 age group had the
lowest incidence rate of 009 per million per-
son-years [12] The incidence of LH was even
less than OAL [13]
Patients with OALD may be asymptomatic or
with symptoms of proptosis eyelid swelling a
palpable painless mass or conjunctival salmon
patch Diplopia visual loss pain or inflamma-
tion occurred less frequently implying more
aggressive features [714]
Orbital LH is not distinguishable from low-grade
lymphoma radiologically They both typically
present a round or lobulated mass that diffusely
moderately enhances with contrast and usually
shows homogenous hypointense or isointense to
muscle barely invasion to bone or nervous sys-
tem [10] Atypical appearances including inho-
mogeneous calcification or bony changes may
be seen in high-grade lymphoma case reports
such as ocular adnexal diffuse large B-cell lym-
phoma (DLBCL) which is one of the more ag-
gressive type of OAL [7] Whole body PET is
used for not only the evaluation of systemic
involvement but also the standard for staging
lymphoma Our patientrsquos image studies revealed
neither obvious local invasion nor systemic ma-
lignancy indicating high-grade lymphoma was
less likely Low-grade lymphoma and benign
reactive lymphoid hyperplasia were still under
consideration
Histomorphology analysis and immunohisto-
chemistry (IHC) are essential for diagnosis
Flow cytometry and polymerase chain reaction
(PCR) technique are also applied to help differ-
entiate from RLH and OAL [1016] Our case
had immunohistochemical profile of positivity
for CD20 predominantly positivity focally for
CD3 CD5 CD10 CD23 and negativity for cy-
clin-D1 BCL-6 staining was not performed in
our casersquos biopsy Thus according to the IHC
report RLH ALH and follicular lymphoma are
probable diagnosis of our patient
Radiation therapy is the standard treatment for
low-grade OAL that is classified as T1N0M0 or
T2N0M0 according to the AJCC criteria [15]
İncesoy-Ouml zdemir S et al reported a 10-year-old
boy diagnosed of MALT lymphoma who was
treated with local radiotherapy (36 Gy) and
there were no local or systemic recurrences dur-
ing his nearly four-year follow-up [17] Another
case report represented a 21-year-old man of
conjunctival follicular lymphoma treated with
surgical excision only showing no evidence of
recurrence after 8 months follow-up [18] Other
treatment options for pediatric and juvenile OAL
were performed in some case reports including
intravenous rituximab intralesional interfer-
on-α-2b topical interferon a6 systemic doxycy-
cline surgical excision and postoperative local
cryotherapy [15]
Treatment for young conjunctival RLH was less
discussed in the past In a case series article
three children (9 13 14 years old respectively)
of RLH received surgical resection without fur-
ther postoperative management and no signs of
recurrence were noted during follow-up [19]
Short-term topical and oral corticosteroids after
surgical excision were prescribed in two pediat-
ric RLH patients for their small residual mass
However poor response in both cases was nota-
ble [20]
Our patient declined to receive radiotherapy or
any further postoperative treatment mainly due
to his concerning of possible side effects (such
as dry eye and cataract)
CONCLUSION We present a rare case of caruncle mass in this
report OALD is one of the relatively uncommon
diagnosis among caruncular lesions OALD
includes benign RLH and malignant OAL
which are both mainly seen in elderly patients
even rarer in pediatric or juvenile group
The standard treatment for low-grade OAL and
RLH in young patents are still debatable How-
ever long-term follow-up is suggested for both
OAL and RLH patients Though RLH has a be-
nign and self-limited course risk of malignant
transformation is possible
REFERENCES 1 Levy J Ilsar M Deckel Y et al Lesions of
the caruncle a description of 42 cases and
a review of the literature Eye
200923(5)1004-1018
2 C-Y Cheng and W-M Hsu Incidence of
eye cancer in Taiwan an 18-year review
Eye 200418152-158
3 Chui-Lien Tsen Muh-Chiou Lin
Youn-Shen Bee et al Ocular adnexal
lymphoma Five case reports and a
literature review Taiwan Journal of
Ophthalmology 20155(2)99-102
4 Liesegang TJ Ocular adnexal
lymphoproliferative lesions Mayo Clin
Proc 199368(10)1003-1010
5 Kirkegaard MM Coupland SE Prause JU
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
115
et al Malignant lymphoma of the
conjunctiva Surv Ophthalmol
201560(5)444-458
6 Stacy RC Jakobiec FA Schoenfield L et
al Unifocal and multifocal reactive
lymphoid hyperplasia vs follicular
lymphoma of the ocular adnexa Am J
Ophthalmol 2010150(3)412-426
7 Sullivan TJ Ocular Adnexal
Lymphoproliferative Disease In Guthoff
RF Katowitz JA eds Oculoplastics and
Orbit Berlin Heidelberg Springer
20101-19
8 White Valerie A Understanding and
Classification of Ocular Lymphomas
Ocular Oncology and Pathology
20195379-386
9 Stefanovic A Lossos IS Extranodal
marginal zone lymphoma of the ocular
adnexa Blood 2009114(3)501-510
10 Andrew NH Coupland SE Pirbhai A et al
Lymphoid hyperplasia of the orbit and
ocular adnexa A clinical pathologic review
Surv Ophthalmol 201661(6)778-790
11 Ferry JA1 Fung CY Zukerberg L et al
Lymphoma of the ocular adnexa A study
of 353 cases Am J Surg Pathol
200731(2)170-184
12 WM Hassan MS Bakry HM Hassan et al
Incidence of orbital conjunctival and
lacrimal gland malignant tumors in USA
from Surveillance Epidemiology and End
Results 1973-2009 Int J Ophthalmol
20169(12)1808-1813
13 Ajay A Rao John H Naheedy James Y-Y
Chen et al A Clinical Update and
Radiologic Review of Pediatric Orbital
and Ocular Tumors Journal of Oncology
2013(9)975908
14 Sullivan TJ Whitehead K Williamson R
et al Lymphoproliferative disease of the
ocular adnexa a clinical and pathologic
study with statistical analysis of 69
patients Ophthal Plast Reconstr Surg
200521177-188
15 Tanenbaum RE Galor A Dubovy SR et al
Classification diagnosis and management
of conjunctival lymphoma Eye Vis (Lond)
2019622
16 Olga Klavdianou Georgios Kondylis
Vasileios Georgopoulos et al Bilateral
benign reactive lymphoid hyperplasia of
the conjunctiva a case treated with oral
doxycycline and review of the literature
Eye Vis (Lond) 2019626
17 İncesoy-Ouml zdemir S Yuumlksek N Bozkurt C
et al A rare type of cancer in children
extranodal marginal zone B-cell (MALT)
lymphoma of the ocular adnexa Turk J
Pediatr 201456(3)295-298
18 Lynn J Poole Perry Frederick A Jakobiec
Peter A D Rubin Conjunctival Pediatric
Follicular Lymphoma Arch Ophthalmol
2012130(7)941-943
19 Abdullah Al-Mujaini Upender Wali
Anuradha Ganesh1 et al Ocular Adnexal
Reactive Lymphoid Hyperplasia in
Children Middle East Afr J Ophthalmol
201219(4)406-409
20 McLeod SD Edward DP Benign
lymphoid hyperplasia of the conjunctiva in
children Arch Ophthalmol
1999117(6)832-835
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
116
FIGURES
Figure 1 Slit lamp image of a mass lesion at the patientrsquos left eye caruncle for one month
Figure 2 One month after the first excision a protruding mass recurred at the patientrsquos nasal canthus
of left eye It partially involved beyond the gray line of nasal part lower eyelid
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
117
Figure 3 Histomorphology analysis and immunohistochemistry study of the caruncular lesion Abun-
dant atypical lymphoid proliferation presented in low-power photomicrograph (A) and
high-power photomicrograph (B) under hematoxylin-eosin staining The lymphoid aggrega-
tion was composed predominantly of CD20-positive cells (C) and focal positive staining of
CD3 (D)
Figure 4 Non-contrast orbital computed tomography showed a lesion of soft tissue density at medial
canthus of left orbit without obvious nasolacrimal duct or bony invasion (A) Magnetic reso-
nance imaging with contrast showed strong enhancement at left medial canthus region (B)
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
118
Figure 5 The follow-up photo were taken at three months after the second excision showing no signs
of recurrence
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
119
Juvenile Caruncular Atypical Lymphoid Proliferation ndash A Rare Case Report
罕見病例報告mdash青少年之淚阜非典型淋巴增生
施驊瑋 1林友祺 1
中文摘要
淚阜病灶相當罕見大部分為良性病灶眼睛及附屬結構淋巴增生疾病為其
鑑別診斷之一非常少見於年輕人或兒童我們報告一位 16歲的健康男性因
左眼淚阜無痛性腫塊接受切除手術卻於術後一個月復發執行第二次切除手術
後門診追蹤十個月未再復發此案例表現了部分良性與部分惡性腫瘤的特徵
我們針對反應性淋巴增生眼睛及附屬結構淋巴癌兩個疾病做討論及文獻回顧
關鍵字淚阜病灶眼睛及附屬結構淋巴增生疾病眼睛及附屬結構淋巴癌反
應性淋巴增生非典型淋巴增生
1 新光吳火獅紀念醫院眼科
通訊作者林友祺 電子信箱 yuchi067gmailcom
Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh 120
Submitted March 26 2020
Final version accepted April 16
2020
Case Report
Hyperacute intramembranous hemor-
rhage after burr hole craniostomy for
chronic subdural hematoma
Cite as Meng-Chi Lin Jui-Ming
Sun Yu-Hao Chen Cheng-Ta
Hsieh
Hyperacute intramembranous
hemorrhage after burr hole crani-
ostomy for chronic subdural he-
matoma Fu-Jen Journal of Medi-
cine 3(4) 120-125 2020
DOI
103966181020932020091803004
Meng-Chi Lin1 Jui-Ming Sun23 Yu-Hao Chen24 Cheng-Ta
Hsieh567
1Department of Surgery Zuoying Branch Kaohsiung Armed Forces
General Hospital Kaohsiung 813 Taiwan 2Section of Neurosurgery Department of Surgery Chia-Yi Christian
Hospital Chia-Yi City 600 Taiwan 3Department of Biotechnology Asia University Taichung City 41354
Taiwan 4Chung-Jen Junior College of Nursing Health Sciences and Manage-
ment Chia-Yi Country 62241 Taiwan 5Division of Neurosurgery Department of Surgery Sijhih Cathay Gen-
eral Hospital New Taipei City 22174 Taiwan 6Department of Medicine School of Medicine Fu Jen Catholic Univer-
sity New Taipei City 24205 Taiwan 7Department of Neurological Surgery Tri-Service General Hospital
National Defense Medical Center Taipei 114 Taiwan
Corresponding author E-mail address
nogormail2000comtw (Cheng-Ta Hsieh)
ABSTRACT
Burr hole craniostomy with closed-system drainage is an effective and common neurosurgical procedure to manage chronic subdural hematoma Postoperative hem-orrhage a well-known but infrequent complication may result in increased neurolog-ical deficits However hyperacute intramembranous hemorrhage within the inner and outer membrane of hematoma after burr hole craniostomy with irrigation and closed-system drainage has not been described previously Herein we report a case of postoperative spontaneous hyperacute intramembranous hemorrhage after burr hole craniostomy with closed-system drainage to manage a chronic subdural hematoma we subsequently discuss the possible pathophysiological mechanisms and review the relevant literature
Keywords Chronic subdural hematoma acute subdural hematoma bleeding burr hole craniostomy
drainage
Fu-J
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Vol 3 No 4 2
Acute intram
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outer and ievidence suggwith or wite and widely ut and that it ] Recurrence r this surgerywever the hyng after burr ely been discucase of a pa
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ISCUSSIO61-year-old won without regd been takingning Ganodermrs She was tment when shurological exasgow Coma S
muscle strengs was 45 on
ale Her laborh the normal rnoted Brain
n revealed Ch a marked m
ently she receniostomy withinage ring surgery mthe subdural sn of the duramatoma The arile saline throsed drainage swever this inm the subduraealed a hyperdural space fniostomy siteniotomy withthe hematom
morrhage was d inner membgure 3) No aface was obseealed an organn of fibroblasne Postoperaogical deficits
EFERENCRohde VComplicatiand closedsubdural analysis of
active bleedinerved Histolonized hematots and capilla
ative recoverywas gradual a
ON oman had a hi
gular medicatig nutritional ma lucidum referred to ohe became proxamination rScale ratings wgth score in th
the Medical ratory examinranges with nn computed
CSDH in the midline shift (ived one righth irrigation a
motor oilndashlikespace was uncal and outer marea was irrigaough the subdusystem was plcreased the rel space An emracute hemorrfrom the frone (Figure 2B
membranectma was perfo
only observebrane of theactive bleedinerved Histolonized hematots and capilla
ative recoverywas gradual a
CES V Graf Gons of burr-
d-system draihematomas
f 376 patient
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Vol 3 No 4 2
Acute intram
Yu-Hao Chen
vealing a layer
displaying a m
quent CT scan
em drainage (
rhage in the ri
2020
membranous
Cheng-Ta Hs
red type of CS
midline shift
ns (A) Bone w
(white arrow)
ight frontal re
hemorrhage
ieh
SDH (white ar
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and (B) Soft
gion (white ar
rrow) in the rig
showed the b
tissue windo
rrow)
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ow showed hy
123
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Fu-J
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Vol 3 No 4 2
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Yu-Hao Chen
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124
mem-
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Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh
125
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
慢性硬腦膜下出血進行鑽顱引流手術造成超急性夾膜內出
血
林孟楫 1孫瑞明 23陳昱豪 24謝政達 567
中文摘要
鑽顱併封閉系統引流手術是治療慢性硬腦膜下出血患者一種有效且常見的
神經外科手術方式術後出血可能導致神經功能缺損惡化是眾所周知但不常見
的併發症之一然而至今仍未有鑽孔併封閉系統引流造成原本慢性硬腦膜血
塊內膜和外膜間急性夾膜間出血案例在這裡我們報告一例慢性硬腦膜下出
血病患者接受鑽顱併封閉系統引流手術治療造成術後急性夾膜間出血我們在
本文中討論可能的致病機制並回顧相關文獻
關鍵字慢性硬腦膜下出血急性硬腦膜下出血出血鑽顱術引流
1國軍高雄總醫院左營分院 外科部
2崇仁醫護管理專科學校
3亞洲大學 生物科技學系
4戴德森醫療財團法人嘉義基督教醫院 外科部 神經外科
5汐止國泰綜合醫院 神經外科
6輔仁大學 醫學系
7 國防醫學院 三軍總醫院 神經外科
通訊作者謝政達 電子信箱 nogormail2000comtw
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
126
Submitted January 21 2020
Final version accepted July 08
2020
Case Report
Hamartoma of the breast A case report
Cite as Hsuan-An Chen
Cheng-Yu Lo Shih-Hung Huang
Chin-Lung Lin
Hamartoma of the breast A case
report Fu-Jen Journal of Medicine
3(5) 126-130 2020
DOI
103966181020932020091803005
Hsuan-An Chen1 Cheng-Yu Lo
3 Shih-Hung Huang
3 Chin-Lung
Lin2
1Department of Surgery Cathay General Hospital Taipei Taiwan
2Department of General Surgery Cathay General Hospital Taipei Tai-
wan
3Department of Pathology Cathay General Hospital Taipei Taiwan
Corresponding author E-mail address
lungyungmailcom (Chin-Lung Lin)
ABSTRACT
Breast hamartoma is an uncommon benign tumor rarely associated with malignancy An
excision and histological examination is necessary for the differential diagnosis We report
a case of a 49-year-old female patient presenting with a lump in the right breast Ultrasound
examination which demonstrated a 4411 cm hypoechoic lesion with lipoma Partial mas-
tectomy was arranged and the diagnosis of a hamartoma was confirmed by the histological
examination
Keywords Breast tumor Hamartoma Ultrasound
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
127
INTRODUCTION The hamartoma is a benign tumor-like lesion
that can affect various organs of the body in-
cluding lungs kidneys skin and more rarely the
breast In 1981 the hamartomas were recognized
in the WHO classification[1] They are defined
as well-demarcated mass of mammary ducts and
lobules containing varying amounts of fibrous
and adipose tissue and producing a distinctive
mammographic image
CASE REPORT A 49 year-old female had past history of left
breast mastitis with abscess status post partial
mastectomy This time she presented to our out
patient clinic for breast examination Physical
examination revealed a painless palpable mova-
ble and painless lump at upper outer quadrant of
right breast The risk of breast cancer was not
noted and the patient did not have any family
history of breast cancer The patient also denied
any trauma history before Ultrasound examina-
tion was arranged which demonstrated a 4411
cm hypoechoic lesion with lipoma at 3 oclock 2
cm from nipple of right breast and multiple hy-
poechoic nodules of various size in both breasts
and there was no suspicious axillary lymph
nodes noted (Figure1) Surgical treatment was
arranged partial mastectomy of right breast
harmartoma was successfully performed A 32 x
31 x 21 cm tumor was completely excised
Grossly examination showed a gray to yellow
and firm to fatty The diagnosis of a hamartoma
was confirmed by the histological examination
Microscopically sections of the breast lesion
show mammary hamartoma composed of ducts
lobules with interlobular fibrous tissue and adi-
pose tissue Fibrocystic change apocrine meta-
plastic ducts and scattered foci of adenosis are
noted The overall lobulocentric architecture and
the 2-cell pattern of the epithelium are preserved
columnar cell change and focal microcalcifica-
tion are present (Figure2) Based on submitted
biopsy specimen in-situ or invasive tumor cells
are not identified
DISCUSSION Hamartoma of the breast is a benign tumor like
nodule it was also known as fibroadenolipoma
lipofibroadenoma or adenolipoma based on its
predominant components It was composed of
varying amounts of glandular adipose and fi-
brous tissue[2] Hamartomas were first described
in 1971 by Arrigoni et al in a study of 10 patients
which breast tumors clinically and grossly re-
sembled fibroadenomas[3]
A higher predominance of tumors exists in fe-
males compared with males Hamartomas are
slowly-growing lesions with the diameter rang-
ing from 2 cm to 5 cm sometimes hamartomas
can reach giant diameter [4]
The clinical diagnosis of hamartoma is based on
the findings from mammography sonography
and histology examinations The hamartomas are
usually incidentally diagnosed by the women
older than 40 year-old starting mammography
screening
On physicial examination harmatomas are usu-
ally occult painless they may be as large mo-
bile soft to firm masses[5] Ultrasound showed
well capsulated mass with echogenic rim and
internal heterogeneity Mammography exam
showed well-circumscribed round to oval
masses containing fat and soft tissue densities
with a thin radiopaque pseudocapsule The
pseudocapsule results from displacement of
breast parenchyma by the tumor [56] In Pa-
thology finding microglandular adenosis is pre-
sent in fibroadipose stroma surrounded by a thin
fibrous capsule It composed of a combination of
epithelial and stromal elements usually with
normal ducts or lobules although variations of
normal tissue may also be seen Fibroadenoli-
poma myoid hamartoma and chondrolipoma are
histological variations of hamartomas depend-
ing on the proportion of normal breast tissue
elements[7]
Malignancy associated with hamartomas are
very rare[8] However it has been reported
hamartomas develop into carcinoma Malignant
transformation can occur as a result of cellular
atypia in the epithelial component of the mass[9]
Surgical removal is the curative method for
breast hamartomas[10] Diagnostic material such
as mammography ultrasonography or core nee-
dle biopsy may not give the definitive diagnosis
Therefore surgical excision and histological
examination is necessary for differential diagno-
sis[111213]
Although it is rare hamartoma can be seen along
with malignancy as it is formed from similar
components of breast tissue Therefore careful
diagnosis and appropriate management including
surgery are required
REFERENCES 1 World Health Organization (1981)
Histological typing of breast tumors In
International histological classification of
tumors 1981 2nd ed
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
128
2 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11435ndash449
2006
3 ArrigoniMG DockertyMB JuddES
The identificationand treatment of
mammary hamartoma Surg Gynecol
Obstet1971 133 577-82
4 Sanal HT Ersoz N Altinel O Unal E Can
C Giant hamartoma of the breast Breast J
2006 12 84-85
5 Feder JM de Paredes ES Hogge JP
Wilken JJ Unusual breast lesions
radiologic-pathologic correlation
Radiographics 1999 19S11ndashS26
6 Murat A Ozdemir H Yildirim H Poyraz
AK Ozercan R Hamartoma of the breast
Australas Radiol 200751 Spec NoB37ndash
9
7 Fisher CJ Hanby AM Robinson L Millis
RR Mammary hamartoma-a review of 35
cases Histopathology 1992 20 99-106
8 Choi N Ko ES Invasive ductal carcinoma
in a mammary hamartoma case report and
review of the literature Korean J Radiol
2010 Nov-Dec11(6)687-91
9 Lee EH Wylie EJ Bourke AG Bastiaan
De Boer W Invasive ductal carcinoma
arising in a breast hamartoma two case
reports and a review of the literature Clin
Radiol 2003 58 80-3
10 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11 435 ‑449
2006
11 Coyne J Hobbs FM Boggis C Harland R
Lobular carcinoma in a mammary
hamartoma J Clin Pathol 199245936ndash
937
12 G M K Tse B K B Law T K F Ma A B W
Chan Hamartoma of the breast a
clinicopathological review J Clin Pathol
200255951ndash954
13 RAAmir SSheikh BreasthamartomaA
report of 14cases of an under-recognized
and under-reported entity International
Journal of Surgery Case Reports
22(2016)1ndash4
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
129
FIGURES
Figure 1 Ultrasound shows a 4411 cm hypoechoic lesion with lipoma at 3 oclock 2 cm from nipple
of right breast
Figure 2 Photomicrograph shows mammary hamartoma composed of ducts lobules with interlobular
fibrous tissue and adipose tissue
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
130
Hamartoma of the breast A case report
乳房錯構瘤罕見個案報告
陳宣安 1羅承裕 3黃世鴻 3林錦龍 2
中文摘要
乳房錯構瘤是一種罕見之乳房良性腫瘤切除手術及病理化驗來做鑑別診斷
我們報告一位 49歲女性以可觸摸到無痛性右側乳房腫塊為臨床表徵超音波
看到一個邊緣清楚低迴音的腫塊病患接受手術切除病灶病理診斷證實為乳
房錯構瘤
關鍵字乳房腫瘤錯構瘤超音波攝影
1國泰綜合醫院外科部
2國泰綜合醫院一般外科
3國泰綜合醫院病理科
通訊作者林錦龍 電子信箱 lungyungmailcom
Fu-Jen Journal of Medicine
Mission and Goals
The Fu-Jen Journal of Medicine (FJJM) is a peer-reviewed journal which
aims to enhance research quality of staffs in the College of Medicine Fu Jen
Catholic University The journal publishes original investigations across a
wide range of medical disciplines including original research articles in basic
and clinical sciences case reports review articles brief reports and letter
to the editor FJJM is now issued by the Center of Medical Education in the
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the manuscript submitted to FJJM after August first 2015 has to be prepared
in English to meet the international standards
Issue Date
Publication Date
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December 01 2003
September 30 2020
College of Medicine Fu Jen Catholic University
Honorable publisher Han-Sun Chiang
Publisher Ping-Keung Yip
Editor-in-chief Ming-Chieh Ma
Associate Editors Yu-Wen Lin
Editors
Telephone (02) 2905-3477
Address Center for Medical Education College of Medicine Fu Jen
Catholic University
No 510 Zhongzheng Rd Xinzhuang Dist New Taipei City
24205 Taiwan
Su-Jane Wang Chi-Chung Wang Chih-Ming Ho
Yih-Jing Lee Chih-Shung Wong Tze-Wah Kao
Chi-Feng Hung Rung-Fen Feng Chee-Fah Chogn
Chia-Chen Lu Zai-Ting Yeh
Dee Pei Chih-Kuang Liu
Hen-Hui Lien Chien-Hsiou Liu
Chun-Hou Liao Yi-Ju Tsai Sheng-Wen Teng
Chia-Ting Su
- 9月封面
- 9月目錄頁
- 2020九月刊排版NO1_完稿
- 2020九月刊排版NO2_完稿
- 2020九月刊排版NO3_完稿
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- 版權頁(SEP)
- 9月封底
-
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pital stay (day
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mplication (no
ean (SD)
of Medicine V
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IQR) POD =
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鴉片
病人
八月
疼痛
20 名
疼痛
創心
關鍵
1新北
2桃園
貢獻
通訊
Jen Journal o
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Compariso
Profil
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鍵字微創
北市板橋區亞
園縣中壢市元
獻相同
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of Medicine V
Wei-Horng Je
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瑞
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何孟潔
後加速康復
的麻醉藥物
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並提供病人快
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亞東紀念醫院麻
元智大學機械工
正威 電子信箱
Vol 3 No 1 2
Remifentani
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entanil and L
ts Undergoi
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方法此研
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皆無顯著差
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麻醉部
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2020
il versus fenta
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尼與低劑量
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宏12林子玉
中文摘要
臟手術病人
速康復中重
使用瑞吩坦
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術後拔管速度
共有 53 名病
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速康復鴉片
weigmailco
nyl for MICS
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ally Invasive
量吩坦尼
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要
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坦尼與低劑量
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間住院天數
我們認為瑞
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r Postopera
e Cardiac Su
尼
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展方向除
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數術後止
究33 名為
數術後止
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藥
ative Recove
urgery
較
除了微創手術
尼是一極短效
對微創心臟手
2018 年五月
止痛藥使用量
為瑞吩坦尼
止痛藥使用量
可安全地用於
98
ery
術方
效的
手術
月至
量
尼組
量
於微
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang
99
Submitted October 11 2019
Final version accepted February
02 2020
Original Research Article
Human Factors Underlying Adverse
Medical Events Revisit Root Cause Anal-
ysis Cases Using the HFACS
Cite as Yu-Hsun Cheng
Sheng-Hui Hung Tung-Wen Ko
Pa-Chun Wang
Human Factors Underlying Ad-
verse Medical Events Revisit
Root Cause Analysis Cases Using
the HFACS Fu-Jen Journal of
Medicine 3(2) 99-111 2020
DOI
103966181020932020091803002
Yu-Hsun Cheng1 Sheng-Hui Hung
12 Tung-Wen Ko
3 Pa-Chun
Wang14
1Department of Quality Management Cathay General Hospital Taipei
Taiwan
2Institute of Health Policy and Management National Taiwan Universi-
ty Taipei Taiwan
3Center for Healthcare Quality Management Cheng Hsin General Hos-
pital Taipei Taiwan
4Fu Jen Catholic University School of Medicine New Taipei City Tai-
wan
Corresponding author E-mail address
drtonyseednettw (Pa-Chun Wang)
ABSTRACT Background Appropriate management of adverse medical events (AMEs) is the corner-
stone of patient safety Root cause analysis (RCA) is used to investigate serious or
high-frequency errors but is limited by its inability to explain a broader scope of factors
We re-reviewed RCA cases to understand the underlying human organizational or system-
ic factors affecting AMEs Methods A total of 40 consecutive RCA cases (2012-2016) were
retrieved from the AMEs database A panel was organized to retrospectively re-review these
cases using the Human Factor Analysis and Classification System HFACS Results For
active failures errors stemmed largely from performance-based (95) judgment and deci-
sion-making errors (875) Incorrectly followed procedures (816) and accidental
equipment operation (50) were the most common types of performance-based errors In-
adequate real-time assessment (686) and inappropriate operative actions (686) were
the most common decision-making errors For sources of latent failure teamwork problems
(275) including failure to effectively communicate (818) and communicate critical
information (727) were common Inadequate supervision (929) or command over-
sights (929) were the most common problems related to inadequate supervision (35)
Organizational programpolicy risks not adequately assessed (50) were the most common
problems related to policy and process problem (25) Conclusions The HFACS review
enhances our understanding of human factors underlying AMEs The HFACS reveals latent
supervisory organizational or systematic problems that cannot be addressed through tradi-
tional RCA Keywords patient safety adverse events root cause analysis human factors
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 100
INTRODUCTION Patient safety involves the reduction of patient
harm from potentially avoidable unintended
outcomes [1] Studies have revealed that 50ndash
80 of adverse medical events (AMEs) are pre-
ventable [2-4] to eliminate such errors the ap-
propriate management of AMEs hence repre-
sents the cornerstone of patient safety work
Through incident reporting investigation and
analysis healthcare providers can correct or
re-engineer their care processes to prevent inci-
dent recurrence [25] One of the most popular
tools for investigating AMEs is root cause anal-
ysis (RCA) RCA reconstructs a chain of errors
to identify the deviation of care from normal
processes Nonetheless with a lack of standard-
ized nomenclature and investigation procedures
RCA report conclusions are sometimes too sub-
jective and nonspecific to facilitate any actiona-
ble safety improvement plans [5-7] According
to the UK Health and Safety Executive defini-
tion human factors are environmental organiza-
tional occupational or individual human char-
acteristics which influence behavior at work
such that health and safety are affected [8] Hu-
mans and systems are prone to errors and stud-
ies have showed that nearly 70 of medical
errors involve human factors [2-4] Reasonrsquos
Swiss cheese model described the penetration of
causative human errors through layers of defen-
sive barriers leading to system collapse [9]
With much focus on the temporal sequence and
severity of departure from accepted practices in
an incident the effectiveness of RCA is often
challenged by its incapability of exploring un-
derlying human organization or even systemic
factors [5-7] Reason and others have proposed
that errors can occur at 4 levels 1) unsafe acts
(operator actions) 2) preconditions for unsafe
acts (environmental factors contributing to er-
rors) 3) inadequate supervision (management
actions affecting the operator) and 4) organiza-
tional influences (organizational culture policies
and procedures that affect the operator) [9]
Based on this theory Wiegmann and Shappell
developed the Human Factor Analysis Classifi-
cation System (HFACS) to describe human fac-
tors causing accidents from 4 tiers of categories
Each of these categories consists of nanocodes to
represent specific human behavior or system
problems leading to errors [9-10] The tier for
unsafe acts involves actual provider actions (er-
rors or rule violations) directly leading to events
The tier representing preconditions for unsafe
acts includes operational personnel and envi-
ronmental factors The supervision tier addresses
leadership problems operational planning fail-
ure or correction and supervisory ethics The
tier for organizational influences deals with re-
source management organizational climate and
operational processes (Supplement Table 1) The
HFACS provides standardized investigation
processes for the systematic analysis of common
causes of adverse events across national defense
nuclear power navy aviation and healthcare
industries Taiwan launched its nationwide
AME-reporting system the Taiwan Patient
Safety Reporting System (TPR) in 2004 RCA
methodology was subsequently introduced to the
healthcare industry by the Joint Commission of
Taiwan [11] Since 2012 appropriate manage-
ment of AMEs has been listed as a national pa-
tient safety goal [12] RCA is required by the
Ministry of Health and Welfare for major AMEs
Aside from RCA a comprehensive structural
reliable and valid framework is urgently re-
quired to further guide organizational or even
national patient safety policies In this study we
used the HFACS to review our RCA cases aim-
ing to investigate human factors underlying se-
vere or frequent AMEs
MATERIALS AND METHODS Through continuous sampling 40 consecutive
RCA cases (2012-2016) were retrieved from a
hospitalrsquos (Cathay General Hospital Taipei
Taiwan) AME-reporting system database The
database contains AMEs relating to areas such as
medication patient falls surgery transfusion
clinical care public accidents security hospital
violence tube-related complication unplanned
cardiopulmonary resuscitation laboratory testing
and examination and anesthesia The RCA cases
were sentinel or high-frequency events classified
according to severity assessment category (SAC)
[1113] The SAC is an evaluation method for
categorizing AMEs by severity of effect on pa-
tients health and risk of incident reoccurrence
The HFACS has been modified (from the US
Department of Defense version 70) and trans-
lated into Mandarin Chinese with authorization
from the original developers [10] The Chi-
nese-version HFACS for Taiwan is a valid in-
strument (content validity index 09 Cronbachrsquos
α gt07 interrater reliability Κ 04-10) equiva-
lent to the original English version [9] The
HFACS contains 4 tiers 13 subitems and 109
nanocodes (Supplement Table 1) A panel of 6
reviewers was established All reviewers were
from clinical or management (quality and patient
safety management) backgrounds Reviewers all
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 101
finished human factor education and were
trained to use the HFACS through a consensus
meeting Each RCA case was randomly assigned
to 2 reviewers Human factors leading to partic-
ular AMEs were identified and confirmed when
2 reviewers reached agreement The distribution
of errors among tiers subitems and nanocodes
are provided with descriptive statistics () The
study was approved by the Institutional Review
Board of Cathay General Hospital
(CGH-P105095)
RESULTS AMEs related to laboratory testing and examina-
tion (n = 16) clinical care (n = 9) and medica-
tion (n = 7) were the most commonly observed
in the RCA Most AMEs in this cohort are
ranked as being SAC level 3 (n = 15) or 4 (n =
17) (Table 1)
Acts (Active Failures)
This tier of errors contains 3 subitems and 13
nanocodes In the 40 RCA cases perfor-
mance-based errors for 38 (95) and judgment
and decision-making errors for 35 (875) com-
prised the most common error types with viola-
tion for 6 (15) less common Procedure fol-
lowed incorrectly for 31 out of 38 (816) was
the most common performance-based problem
Inadequate real-time risk management for 24 out
of 35 (686) was the most common judgment
or decision error All of the rule violations were
workaround types for 6 out of 6 (100) (Figure
1)
Preconditions(Latent Failures)
This tier of errors has 9 subitems and 58 nano-
codes In the 40 RCA cases teamwork for 11
(275) and environmental for 8 (20) factors
contributed to most of the errors with mental
and physical state the next most common factor
for 7 (175) Communication for 9 out of 11
(818) and information relay for 8 out of 11
(727) were the most common issues related to
teamwork Few contributors mentioned failures
related to technical errors for 4 (50) or physi-
cal for 1 (125) environment Not paying at-
tention for 4 out of 7 (571) and negative habit
transfer for 4 out of 7 (571) were common
mental contributes noted for 7 (100) Overcon-
fidence was the most common problem related
to emotional status for 4 out of 7 (571) Fa-
tigue was observed in only 2 cases for 2 out of 2
physical problems (100) (Figure 2)
Supervision(Direct Supervisory Chain of
Command)
This tier of errors contains 3 subitems and 17
nanocodes In the 40 RCA cases inadequate
supervision for 14 (35) and inappropriately
planned operations for 11 (275) factors con-
tributed to most of the respective errors fol-
lowed by supervisory violations for 7 (175)
Supervisory or command oversights for 13 out
of 14 (929) were the most common sources of
supervision inadequacy Authorized unnecessary
hazards for 7 out of 11 (636) were the most
common inappropriately planned operations
Failure to enforce rules for 6 out of 7 (857)
was the most common supervisory violation
(Figure 3)
Organization Influence (Upper-Level Man-
agement)
This tier of errors contains 4 subitems and 18
nanocodes In the 40 RCA cases policy and
process issues for 10 (25) and resources prob-
lem for 8 (20) were major concerns Few of
the respective problems are related to climate
and cultural influences for 2 (5) or to person-
nel selection and staffing for 1 (25) Poorly
assessed organizational programs or policy risks
for 5 out of 10 (50) were the most common
policy and process problems Failure to provide
adequate operational information resources for 4
out of 8 (50) and command and control re-
source deficiency for 3 out of 8 (375) were
the main resource management problems Little
was revealed regarding organizational climate
and culture (n = 1 out of 2 50) or staffing for 1
out of 1 (100) (Figure 4)
DISCUSSION Health care is a complex system comprising
many high-reliability organizations (HROs) The
vulnerability of HROs stems from the participa-
tion of multidisciplinary teams in the processes
along a variety of patient care timelines How-
ever humans and systems are inherently prone
to errors the appropriate management of AMEs
is acknowledged to be the cornerstone of patient
safety AMEs should be reported investigated
analyzed and handled appropriately[14] Theo-
retically by analyzing the pattern of key defects
providers can fix errors and re-engineer their
care processes to reduce the possibility of AME
recurrence Taiwan established its nationwide
TPR in 2004 so far 7000 health care facilities
have participated and the database has accumu-
lated more than 055 million AMEs[11] Infor-
mation generated from the TPR database can
improve patient safety at individual organiza-
tional or even national levels However despite
relentless efforts few substantial improvements
have been achieved in patient safety [15-17]
Since its introduction in Taiwan in 2006 the use
of RCA for AMEs has encountered some diffi-
culties 1) No structural and standardized
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 102
framework exists for investigation
cross-institution variability and interrater relia-
bility are often ignored 2) Conclusions are often
subjective and corrective recommendations are
less actionable relying on individual reviewersrsquo
professional backgrounds and their experiences
3) Much focus on event reconstruction and oper-
ator performance means that factors relating to
human behavior organizational culture and
system weakness are not comprehensively ad-
dressed [671718] Traditionally attempts to
improve patient safety in the health care industry
are largely reactive in nature identifying and
correcting errors in care processes [1920]
Causes of defects are not thoroughly understood
Proactive approaches must be taken to address
systematic problems within a complex system
[720] Research suggests that human error is a
causal factor in the occurrence of AMEs AME
investigation targets have moved from skill defi-
ciency toward decision-making attitudes super-
visory factors and even organizational climate
or culture HFACS methodology is based on the
Swiss cheese model that also emphasizes active
and latent failures [921] The study provides
some noteworthy findings First most AMEs as
expected involve active failures such as failure
to follow procedure accidental operation of
equipment inadequate real-time risk manage-
ment and inappropriate action These are all
sharp ends in classic RCA environment physi-
cal and mental factors are less prevalent This
proves that retrospectively determining addi-
tional causal factors is difficult when infor-
mation has not been collected during preliminary
investigation (Figure 1) Second team-
work-related problems particularly in relation to
communication and information relay are well
addressed This may be attributed to the dec-
ade-long institution-wide routine crew resource
management training in the respective research
hospital (Figure 2) Third the HFACS success-
fully reflects the importance of supervisory roles
in the occurrence of AMEs and this cannot be
overlooked (Figure 3) Fourth latent failures
especially in organizational climate or cultural
dimensions have been less frequently addressed
in incident reports a limitation of traditional
RCA However the HFACS review suggests
room for improvement in resource allocation and
policy modification within the hospital The
results of studies can make the organization
think about how to improve the patient safety
and management process from the perspective of
human factors such as improving the comfort of
the working environment and replacing and
equipment resources to prevent personnel from
affecting the medical quality and patient safety
due to the environment or equipment Need to
appropriate assessment of applicability and ade-
quate training of manpower is required The
management and control of risks should be fully
evaluate and grasp resource management and
leaders need to participate in and promote medi-
cal quality and patient safety activities to en-
hance its culture (Figure 4) No panacea exists
to ensure patient safety and improvement targets
originate largely from event investigation find-
ings Unfortunately factors identified from
AMEs are often self-explanatory with little value
for further action correction Reinforcement of
policy or processes redundant education or
repetitious training are formulaic overprescribed
RCA recommendations The use of HFACS in
this study proves that a structural prospective
AME investigation format can potentially help
with proactive patient safety management We
suggest developing an interview guideline for
the routine use of HFACS as a complement to
RCA in every AME investigation This study is a
retrospective study The underlying human fac-
tors can be under-estimated owing to the lack of
related information in the original RCA reports
CONCLUSION The HFACS review in this study enhances our
understanding of human factors in AMEs that
had previously been insufficiently scrutinized
Aside from active process and communication
errors the HFACS enables the prospective in-
vestigation of latent supervisory organizational
or systematic problems that cannot be addressed
through traditional RCA
REFERENCES 1 T Brennan L Leape N Laird et al
Incidence of adverse events and
negligence in hospitalized patients results
of the Harvard Medical Practice Study I N
Engl J Med 1991324370-376
2 Wang CH Shih CL Chen WJ et al
Epidemiology of medical adverse events
perspectives from a single institute in
Taiwan J Formos Med Assoc
2016115434-439
3 Vincent C Simon R Sutcliffe K et al
Errors Conference Executive Summary
Acad Emerg Med 200071180-1182
4 Taitz J Genn K Brooks V et al
System-wide learning from root cause
analysis A report from the New South
Wales Root Cause Analysis Review
Committee Qual Saf Health Care
2010191-5
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 103
5 Hutchinson A Young TA Cooper KL et
al Trends in healthcare incident reporting
and relationship to safety and quality data
in acute hospitals results from the
National Reporting and Learning System
Qual Saf Health Care 2009185-10
6 Mitchell RJ Williamson AM Molesworth
B et al A review of the use of human
factors classification frameworks that
identify causal factors for adverse events
in the hospital setting Ergonomics
2014571443-1472
7 Gurses AP Ozok AA Pronovost PJ Time
to accelerate integration of human factors
and ergonomics in patient safety BMJ
Qual Saf 201221347-351
8 Health and Safety Executive Introduction
to human factors
httpwwwhsegovukhumanfactorsintro
ductionhtm
9 Wiegmann DA Shappell SA A human
error approach to aviation accident
analysis The human factors analysis and
classification system Burlington VT
Ashgate Publishing Ltd 2003
10 Yu-Hsun Cheng Sheng-Hui Hung
Tung-Wen Ko et al An Analysis of the
Reliability and Validity of Human Factors
Analysis Classification System in Medical
Adverse Events Journal of Healthcare
Quality 20191370-76
11 Taiwan Joint Commission on Hospital
Accreditation Taiwan Patient-Safety
Reporting System Annual Report 2017
New Taipei City Taiwan
12 Taiwan Patient Safety Net
httpwwwpatientsafetymohwgovtwCo
ntentzMessagesslistaspxSiteID=1ampMm
mID=621273300317401756
13 Government of Western Australia
Department of Health
httpsww2healthwagovauArticlesS_T
Severity-assessment-codes
14 Farley DO Haviland A Champagne S et
al Adverse-event-reporting practices by
US hospitals results of a national survey
Qual Saf Health Care 200817416-423
15 Shojania KG Thomas EJ Trends in
adverse events over time why are we not
improving BMJ Qual Saf
201322273-277
16 Levitt P Challenging the systems approach
why adverse event rates are not improving
BMJ Qual Saf 2014231051-1052
17 Kellogg KM Hettinger Z Shah M et al
Our current approach to root cause
analysis is it contributing to our failure to
improve patient safety BMJ Qual Saf
201726381-387
18 Khorsandi M Skouras C Beatson K et al
Quality review of an adverse incident
reporting system and root cause analysis of
serious adverse surgical incidents in a
teaching hospital of Scotland Patient Saf
Surg 2012621
19 Diller T Helmrich G Dunning S et al
The Human Factors Analysis
Classification System (HFACS) Applied to
Health Care Am J Med Qual
201429181-190
20 Carayon P Xie A Kianfar S Human
factors and ergonomics as a patient safety
practice BMJ Qual Saf 201423196-205
21 Reason J Human Error New York
Cambridge University Press 1990
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 104
TABLE
Table 1 Incidences by Category (N=40)
CategorySAC SAC 4 SAC 3 SAC 2 SAC 1 total
Laboratory and ex-
amination events
4 10 2 0 16 (400)
Clinical care event 6 2 1 0 9 (225)
Medication event 5 0 2 0 7 (175)
Surgery-related event 1 1 2 0 4 (100)
Transfusion-related
event
1 1 0 0 2 (50)
Tube event 0 1 0 0 1 (25)
Public accident 0 0 1 0 1 (26)
Total 17 (425) 15 (375) 8 (200) 0 40 (100)
SAC 1113 Severity Assessment Code SAC
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 105
FIGURES
Figure 1 Active Failures (N=40)
16 (167)
66 (1000)
640 (150)
235 (57)
735 (200)
2435 (686)
2435 (686)
3540 (875)
438 (105)
438 (105)
738 (184)
1938 (500)
3138 (816)
3840 (950)
0 5 10 15 20 25 30 35 40
Commits WidespreadRoutine Violation
Performs Work-Around Violation
Ignored a CautionWarning
Failure to Prioritize Tasks Adequately
Wrong Choice of Action During an Operation
Inadequate Real‐Time Risk Assessment
Rushed or Delayed a Necessary Action
Breakdown in Visual Scan
Over-ControlledUnder-Controlled AircraftVehicleSystem
Unintended Operation of Equipment
Procedure Not Followed Correctly
Performance-Based Errors
Judgment and Decision Making Errors
Violations
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 106
Figure 2 Preconditions (Latent Failures or Conditions) (N=40)
14 (250)
24 (500)
48 (500)
11 (1000)
18 (125)
840 (200)
0 5 10 15 20 25 30 35 40
Seat and Restraint System Problems
Instrumentation amp Warning System Issues
Noise Interference
Environment
Physical Environment
Technological Environment
27 (286)
27 (286)
27 (286)
37 (129)
47 (511)
47 (571)
77 (1000)
24 (500)
44 (1000)
47 (571)
12 (500)
22 (1000)
27 (286)
740 (175)
0 5 10 15 20 25 30 35 40
Technical or Procedural Knowledge Not Retained After Training
InterferenceInterruption
Task OverUnder Saturation
Distraction
Negative Habit Transfer
Not Paying Attention
Complacency
Overconfidence
Physical IllnessInjury
Fatigue
Physical and Mental State
Physical Problem
State of Mind
Mental Awareness
211 (182)
311 (273)
311 (273)
411 (364)
811 (7227)
911 (818)
1140 (275)
0 5 10 15 20 25 30 35 40
Inadequate Task Delegation
TaskMission PlanningBriefingDebriefing Inadequate
Failure of CrewTeam Leadership
StandardProper Terminology Not Used
Critical Information Not Communicated
Failed to Effectively Communicate
Teamwork
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 107
Figure 3 Supervision (Direct Supervisory Chain of Command) (N=40)
Figure 4 Organization Influence (Upper-Level Management Command Level) (N=40)
114 (71)
114 (71)
214 (143)
314 (214)
1314 (929)
1440 (350)
511 (455)
511 (455)
711 (636)
1140 (275)
47 (571)
67 (857)
740 (175)
0 5 10 15 20 25 30 35 40
Selected Individual with Lack of Proficiency
Improper Role‐modeling
Failed to Provide Proper Training
Failed to IdentifyCorrect Risky or Unsafe Practices
SupervisoryCommand Oversight Inadequate
Performed Inadequate Risk Assessment ‐Formal
Selected Individual with Lack of Current or Limited Experience
Authorized Unnecessary Hazard
Allowing Unwritten Policies to Become Standard
Failure to Enforce Existing Rules
Supervisory Violations
Planned Inappropriate Operations
Inadequate Supervision
12 (500)
12 (500)
240 (50)
110 (100)
510 (500)
1040 (250)
11 (1000)
140 (25)
18 (125)
18 (125)
38 (35)
48 (500)
840 (200)
0 5 10 15 20 25 30 35 40
Organizational Over-confidence or Under-confidence in Equipment
Organizational Culture (attitude actions) Allows for Unsafe TaskMission
Purchasing or Providing Poorly Designed or Unsuitable Equipment
Organizational ProgramPolicy Risks not Adequately Assessed
Failure to Provide Adequate Manning Staffing Resources
Failure to remove inadequate worn-out equipment in timely manner
Inadequate infrastructure
Command and control resources are deficient
Failure to provide adequate operational information resources
Resource Problems
Personnel Selection amp Staffing
Policy and Process Issues
ClimateCulture Influences
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 108
Supplement Table 1- HFACS Content of Human Factor Analysis Classifi-
cation System [9] Tier main level sub-item nano code
Tier 1 Unsafe Acts
Perfor-
mance-Based
Errors
Unintended operation of equipment
Checklist not followed correctly
Procedure not followed correctly
Over-controlledunder-controlled aircraftvehiclesystem
Breakdown in visual scan
Rushed or delayed a necessary action
Judgment amp De-
cision-Making
Errors
Inadequate real‐time risk assessment
Failure to prioritize tasks adequately
Ignored a cautionwarning
Wrong choice of action during an operation
Violations
Performs work-around violation
Commits widespreadroutine violation
Extreme violation-lack of discipline
Tier 2 Preconditions
Environment
Physical environment
Environmental conditions affecting vision
Vibration effects vision or balance
Heatcold stress impairs performance
External force of object impeded an individualrsquos
movement
Lights of other vehiclevesselaircraft affected vision
Noise interference
Technological environment
Seat and restraint system problems
Instrumentation amp warning system issues
Visibility restrictions (not weather related)
Controls and switches are inadequate
Automated system creates unsafe situation
Workspace incompatible with operation
Personal equipment interference
Communication equipment inadequate
Physical and
Mental State
Physical problem
Substance effects (alcohol supplements medications
drugs)
Loss of consciousness (sudden or prolonged onset)
Physical illnessinjury
Fatigue
Inadequate adaptation to darkness
Dehydration
Body sizemovement limitations
Physical strength amp coordination (inappropriate for
task demands)
Nutritiondiet
State of mind
Psychological problem
Life stressors
Emotional state
Personality style
Overconfidence
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 109
Pressing
Complacency
Motivation
Motivational exhaustion (burnout)
Sensory misperception
Motion illusion-kinesthetic
Turning illusionbalance-vestibular
Visual illusion
Misperception of changing environment
Misinterpreted misread instrument
Misinterpretation of auditorysound cues
Spatial disorientation
Temporaltime distortion
Mental awareness
Not paying attention
Fixation
Task overunder saturation
Confusion
Negative habit transfer
Distraction
Geographically lost
Interferenceinterruption
Technical or procedural knowledge not retained after
training
Inaccurate expectation
Teamwork
Failure of crewteam leadership
Inadequate task delegation
Rankposition intimidation
Lack of assertiveness
Critical information not communicated
Standardproper terminology not used
Failed to effectively communicate
Taskmission planningbriefingdebriefing inadequate
Tier 3 Supervision
Supervisory Vio-
lations
Failure to enforce existing rules
Allowing unwritten policies to become standard
Directed individual to violate existing regulations
Authorized unqualified individuals for task
Planned Inappro-
priate Operations
Directed task beyond personnel capabilities
Inappropriate team composition
Selected individual with lack of current or limited experience
Performed inadequate risk assessment ‐formal
Authorized unnecessary hazard
Inadequate Su-
pervision
Supervisorycommand oversight inadequate
Improper role‐modeling
Failed to provide proper training
Failed to provide appropriate policyguidance
Personality conflict with supervisor
Lack of supervisory responses to critical information
Failed to identifycorrect risky or unsafe practices
Selected individual with lack of proficiency
Tier 4 Organizational
Influences
Resource Prob-
lems
Command and control resources are deficient
Inadequate infrastructure
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 110
Failure to remove inadequate worn-out equipment in timely
manner
Failure to provide adequate operational information resources
Fail to provide adequate funding
Personnel Selec-
tion amp Staffing
Personnel recruiting amp selection policies are inadequate
Failure to provide adequate manning staffing resources
Policy amp Process
Issues
Pace of ops-tempoworkload
Organizational programpolicy risks not adequately assessed
Provided inadequate procedural guidance or publications
Organizational (formal) training is inadequate or unavailable
Flawed doctrinephilosophy
Inadequate program management
Purchasing or providing poorly designed or unsuitable equip-
ment
ClimateCulture
Influences
Organizational culture (attitude actions) allows for unsafe
taskmission
Organizational over-confidence or under-confidence in equip-
ment
Unit missionaircraftvehicleequipment change or unit deacti-
vation
Organizational structure is unclear or inadequate
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 111
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
以 HFACS重新檢視根本原因分析案例挖掘造成醫療不良
事件之人為因素
鄭伃洵 1洪聖惠 12柯彤文 3王拔群 14
中文摘要
背景醫療不良事件(AMEs)的管理是促進病人安全的基石根本原因分析
(RCA)是探討重大病人安全不良事件問題但是由於無法解釋更廣泛的因素而受
到限制本研究使用人為因素分類與分析工具(HFACS)回溯審視醫療不良事件
以了解影響醫療不良事件的人為因素及各層面中錯誤原因之分佈或系統性問題
方法本研究回溯 2012-2016年間有做過根本原因分析之醫療不良事件以連續
性取樣方式(continuous sampling)收集 40例醫療不良事件以人為因素分類與分
析工具(HFACS)去系統性的挖掘每件案例發生錯誤之原因結果在行為層面中
分析結果主要為基礎技能錯誤(95)判斷和決策錯誤(875)其中在基礎技能
錯誤當中以未依程序作業執行(816)及未如預期設備操作(50)佔多數判斷和
決策錯誤中以現場風險評估不確實(686)及採取錯的步驟行為(686)佔多數
而在先決條件層面中以團隊合作(275)為主要因素包含溝通不良(818)及重
要訊息未以正確的方式即時傳達(727)佔多數在監督層面當中以監督不周
(929)或監督不妥當(929)為主要因素在組織政策和流程方面(50)以組織
系統的政策風險未充分評估(35)為主要因素結論本研究進一步了解醫療不
良事件在過去使用根本原因分析未探討到的人為因素反映出潛在的監督組織
行為或系統性的問題促進病人安全預防錯誤再發生
關鍵字病人安全醫療不良事件根本原因分析人為因素
1國泰醫療財團法人國泰綜合醫院 品質管理部
2國立臺灣大學健康政策與管理研究所
3振興醫療財團法人振興醫院 醫療品質管理中心
4輔仁大學醫學院
通訊作者王拔群 電子信箱 drtonyseednettw
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin 112
Submitted January 20 2020
Final version accepted April13
2020
Case Report
Juvenile Caruncular Atypical Lymphoid
Proliferation ndash A Rare Case Report
Cite as Hua-Wei Shih Yu-Chi Lin
Juvenile Caruncular Atypical
Lymphoid Proliferation ndash A Rare
Case Report Fu-Jen Journal of
Medicine 3(3) 112-119 2020
DOI
103966181020932020091803003
Hua-Wei Shih1 Yu-Chi Lin
1
1Department of Ophthalmology Shin Kong Wu Ho-Su Memorial Hos-
pital Taipei City Taiwan
Corresponding author E-mail address
yuchi067gmailcom (Yu-Chi Lin)
ABSTRACT
Lesions of the caruncle are very rare Most caruncular lesions are benign though there were still few reported malignant lesions Ocular adnexal lymphoproliferative disease (OALD) one of the differential diagnosis of caruncular lesion is seldom seen in young pa-tient In this article we report a 16-year-old boy with recurrent caruncular atypical lym-phoid proliferation We discuss the epidemiology clinical features images histomorpholo-gy and treatment between ocular adnexal lymphomas (OAL) and reactive lymphoid hyper-plasia (RLH)
Keywords caruncular lesion ocular adnexal lymphoproliferative disease ocular adnexal lymphoma
reactive lymphoid hyperplasia atypical lymphoid proliferation
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
113
INTRODUCTION Lesions of the caruncle are very rare Differen-
tial diagnosis includes nevus myeloproliferative
disorders tumors inflammation infection cysts
vascular lesions and fibrous Biopsy is essential
for diagnosis Levy J et al reported ocular ad-
nexal lymphoproliferative disease (OALD) was
relatively uncommon diagnosis among caruncu-
lar lesions [1]
OALD was seldom described in Asian popula-
tion especially for young age C-Y Cheng re-
ported age-standardized incidence of ocular
adnexal lymphomas (OAL) in Taiwan from 1979
to 1996 was below 07 per million per year and
mean age was 531 years old [2] In 2015 five
Taiwanese cases of OAL whose age ranging
from 45 to 64 were presented [3] However
there were few cases of conjunctival OAL or
RLH in Chinese pediatric patient
Here we present a case of 16-year-old boy with a
caruncular mass at his left eye with recurrence
one month after excision We describe his clini-
cal symptoms photographs pathological results
management and follow-up clinical course in
this report
CASE REPORT A 16-year-old healthy boy presented a mass
lesion at his left eye caruncle accompanied with
the symptom of tearing for one month (Figure 1)
He had no ocular pain no itchiness no blurred
vision no night sweating no fever and no body
weight loss The patient denied systemic diseas-
es and histories of surgery His bilateral best
corrected visual acuity (BCVA) were 66 and
intraocular pressure (IOP) were both within
normal range There were no remarkable find-
ings for his cornea lens fundus and physical
examination Excision was performed and the
mass was soft with fluid inside therefore con-
junctival pyogenic cyst was our initial diagnosis
However one month after the excision a pro-
truding mass recurred at the patientrsquos nasal can-
thus of left eye (Figure 2) There were some
differences compared to previous condition At
the first time the soft mass was contained in a
well-defined cyst wall which more favored py-
ogenic granulation However after short period
of recurrence solid consistency and unclear
margin were found which favored malignancy
Besides the mass partially involved beyond the
gray line of nasal part lower eyelid whereas last
time the cyst mainly extended from conjunctiva
of caruncle The second excisional biopsy was
performed Pathologic examination demonstrat-
ed abundant atypical lymphoid proliferation
(Figure 3A 3B) Immunohistochemical studies
showed that the lymphoid aggregation was
composed predominantly of CD20-positive cells
(Figure 3C) focal positive staining of CD3
(Figure 3D) CD5 CD23 CD10 and negative
staining of cyclin-D1 Unfortunately the cellular
morphology was difficult to be evaluated due to
marked crushing artifact Thus malignant lym-
phoma cannot be excluded totally
Orbital computed tomography (CT) showed a
lesion of soft tissue density at medial canthus of
left orbit without obvious nasolacrimal duct or
bony invasion (Figure 4A) Magnetic resonance
imaging (MRI) with contrast showed strong
enhancement at left medial canthus region (Fig-
ure 4B) There was no remarkable finding in the
systemic workup including complete blood
count and differential count biochemical pro-
files and 18F-fluoro-2-deoxyglucose positron
emission tomographycomputed tomography
(18F-FDG PETCT) indicating no evidence of
systemic involvement
After the second excision we preferred con-
servative management for him due to the uncer-
tainty of malignancy and to avoid side effects
from aggressive treatment No sign of recurrence
was noted after 10 months of observation The
follow-up photo was taken at three months after
the second operation (Figure 5)
DISCUSSION Ocular adnexal lymphoproliferative disease
(OALD) consists of the spectrum of lymphoid
disease affecting the tissues surrounding the eye
including ocular adnexal lymphomas (OAL) and
lymphoid hyperplasia (LH) [4] The conjunctiva
is an important location for extranodal lympho-
ma development which comprises 25 of OAL
[5]
OAL can be grouped into two categories based
on their appearance of cells under the micro-
scope low-grade and high-grade [6] Extranodal
marginal zone lymphoma of mucosa-associated
lymphoid tissue (EMZLMALT) is the most
common subtype of OAL followed by follicular
lymphoma [7-9] Both of the above are
low-grade lymphomas
LH can be further divided by histopathology into
reactive lymphoid hyperplasia (RLH) and atypi-
cal lymphoid hyperplasia (ALH) RLH has to-
tally benign morphology and immunophenotype
whereas ALH has borderline lesions between
RLH and lymphoma [10] OAL and LH are
mostly seen in patients with age between 50-70
years old There are rare cases in pediatric group
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
114
[71011] In the C-Y Chengrsquos statistical report of
OAL in Taiwan only 8 patients were younger
than 15 years old among the 101 cases of ocular
lymphoma [2] According to an US study inci-
dence rates of OAL were analyzed in different
age groups the group of age over 50 had the
highest incidence rate of 574 per million per-
son-years while the 0-19 age group had the
lowest incidence rate of 009 per million per-
son-years [12] The incidence of LH was even
less than OAL [13]
Patients with OALD may be asymptomatic or
with symptoms of proptosis eyelid swelling a
palpable painless mass or conjunctival salmon
patch Diplopia visual loss pain or inflamma-
tion occurred less frequently implying more
aggressive features [714]
Orbital LH is not distinguishable from low-grade
lymphoma radiologically They both typically
present a round or lobulated mass that diffusely
moderately enhances with contrast and usually
shows homogenous hypointense or isointense to
muscle barely invasion to bone or nervous sys-
tem [10] Atypical appearances including inho-
mogeneous calcification or bony changes may
be seen in high-grade lymphoma case reports
such as ocular adnexal diffuse large B-cell lym-
phoma (DLBCL) which is one of the more ag-
gressive type of OAL [7] Whole body PET is
used for not only the evaluation of systemic
involvement but also the standard for staging
lymphoma Our patientrsquos image studies revealed
neither obvious local invasion nor systemic ma-
lignancy indicating high-grade lymphoma was
less likely Low-grade lymphoma and benign
reactive lymphoid hyperplasia were still under
consideration
Histomorphology analysis and immunohisto-
chemistry (IHC) are essential for diagnosis
Flow cytometry and polymerase chain reaction
(PCR) technique are also applied to help differ-
entiate from RLH and OAL [1016] Our case
had immunohistochemical profile of positivity
for CD20 predominantly positivity focally for
CD3 CD5 CD10 CD23 and negativity for cy-
clin-D1 BCL-6 staining was not performed in
our casersquos biopsy Thus according to the IHC
report RLH ALH and follicular lymphoma are
probable diagnosis of our patient
Radiation therapy is the standard treatment for
low-grade OAL that is classified as T1N0M0 or
T2N0M0 according to the AJCC criteria [15]
İncesoy-Ouml zdemir S et al reported a 10-year-old
boy diagnosed of MALT lymphoma who was
treated with local radiotherapy (36 Gy) and
there were no local or systemic recurrences dur-
ing his nearly four-year follow-up [17] Another
case report represented a 21-year-old man of
conjunctival follicular lymphoma treated with
surgical excision only showing no evidence of
recurrence after 8 months follow-up [18] Other
treatment options for pediatric and juvenile OAL
were performed in some case reports including
intravenous rituximab intralesional interfer-
on-α-2b topical interferon a6 systemic doxycy-
cline surgical excision and postoperative local
cryotherapy [15]
Treatment for young conjunctival RLH was less
discussed in the past In a case series article
three children (9 13 14 years old respectively)
of RLH received surgical resection without fur-
ther postoperative management and no signs of
recurrence were noted during follow-up [19]
Short-term topical and oral corticosteroids after
surgical excision were prescribed in two pediat-
ric RLH patients for their small residual mass
However poor response in both cases was nota-
ble [20]
Our patient declined to receive radiotherapy or
any further postoperative treatment mainly due
to his concerning of possible side effects (such
as dry eye and cataract)
CONCLUSION We present a rare case of caruncle mass in this
report OALD is one of the relatively uncommon
diagnosis among caruncular lesions OALD
includes benign RLH and malignant OAL
which are both mainly seen in elderly patients
even rarer in pediatric or juvenile group
The standard treatment for low-grade OAL and
RLH in young patents are still debatable How-
ever long-term follow-up is suggested for both
OAL and RLH patients Though RLH has a be-
nign and self-limited course risk of malignant
transformation is possible
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the caruncle a description of 42 cases and
a review of the literature Eye
200923(5)1004-1018
2 C-Y Cheng and W-M Hsu Incidence of
eye cancer in Taiwan an 18-year review
Eye 200418152-158
3 Chui-Lien Tsen Muh-Chiou Lin
Youn-Shen Bee et al Ocular adnexal
lymphoma Five case reports and a
literature review Taiwan Journal of
Ophthalmology 20155(2)99-102
4 Liesegang TJ Ocular adnexal
lymphoproliferative lesions Mayo Clin
Proc 199368(10)1003-1010
5 Kirkegaard MM Coupland SE Prause JU
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
115
et al Malignant lymphoma of the
conjunctiva Surv Ophthalmol
201560(5)444-458
6 Stacy RC Jakobiec FA Schoenfield L et
al Unifocal and multifocal reactive
lymphoid hyperplasia vs follicular
lymphoma of the ocular adnexa Am J
Ophthalmol 2010150(3)412-426
7 Sullivan TJ Ocular Adnexal
Lymphoproliferative Disease In Guthoff
RF Katowitz JA eds Oculoplastics and
Orbit Berlin Heidelberg Springer
20101-19
8 White Valerie A Understanding and
Classification of Ocular Lymphomas
Ocular Oncology and Pathology
20195379-386
9 Stefanovic A Lossos IS Extranodal
marginal zone lymphoma of the ocular
adnexa Blood 2009114(3)501-510
10 Andrew NH Coupland SE Pirbhai A et al
Lymphoid hyperplasia of the orbit and
ocular adnexa A clinical pathologic review
Surv Ophthalmol 201661(6)778-790
11 Ferry JA1 Fung CY Zukerberg L et al
Lymphoma of the ocular adnexa A study
of 353 cases Am J Surg Pathol
200731(2)170-184
12 WM Hassan MS Bakry HM Hassan et al
Incidence of orbital conjunctival and
lacrimal gland malignant tumors in USA
from Surveillance Epidemiology and End
Results 1973-2009 Int J Ophthalmol
20169(12)1808-1813
13 Ajay A Rao John H Naheedy James Y-Y
Chen et al A Clinical Update and
Radiologic Review of Pediatric Orbital
and Ocular Tumors Journal of Oncology
2013(9)975908
14 Sullivan TJ Whitehead K Williamson R
et al Lymphoproliferative disease of the
ocular adnexa a clinical and pathologic
study with statistical analysis of 69
patients Ophthal Plast Reconstr Surg
200521177-188
15 Tanenbaum RE Galor A Dubovy SR et al
Classification diagnosis and management
of conjunctival lymphoma Eye Vis (Lond)
2019622
16 Olga Klavdianou Georgios Kondylis
Vasileios Georgopoulos et al Bilateral
benign reactive lymphoid hyperplasia of
the conjunctiva a case treated with oral
doxycycline and review of the literature
Eye Vis (Lond) 2019626
17 İncesoy-Ouml zdemir S Yuumlksek N Bozkurt C
et al A rare type of cancer in children
extranodal marginal zone B-cell (MALT)
lymphoma of the ocular adnexa Turk J
Pediatr 201456(3)295-298
18 Lynn J Poole Perry Frederick A Jakobiec
Peter A D Rubin Conjunctival Pediatric
Follicular Lymphoma Arch Ophthalmol
2012130(7)941-943
19 Abdullah Al-Mujaini Upender Wali
Anuradha Ganesh1 et al Ocular Adnexal
Reactive Lymphoid Hyperplasia in
Children Middle East Afr J Ophthalmol
201219(4)406-409
20 McLeod SD Edward DP Benign
lymphoid hyperplasia of the conjunctiva in
children Arch Ophthalmol
1999117(6)832-835
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
116
FIGURES
Figure 1 Slit lamp image of a mass lesion at the patientrsquos left eye caruncle for one month
Figure 2 One month after the first excision a protruding mass recurred at the patientrsquos nasal canthus
of left eye It partially involved beyond the gray line of nasal part lower eyelid
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
117
Figure 3 Histomorphology analysis and immunohistochemistry study of the caruncular lesion Abun-
dant atypical lymphoid proliferation presented in low-power photomicrograph (A) and
high-power photomicrograph (B) under hematoxylin-eosin staining The lymphoid aggrega-
tion was composed predominantly of CD20-positive cells (C) and focal positive staining of
CD3 (D)
Figure 4 Non-contrast orbital computed tomography showed a lesion of soft tissue density at medial
canthus of left orbit without obvious nasolacrimal duct or bony invasion (A) Magnetic reso-
nance imaging with contrast showed strong enhancement at left medial canthus region (B)
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
118
Figure 5 The follow-up photo were taken at three months after the second excision showing no signs
of recurrence
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
119
Juvenile Caruncular Atypical Lymphoid Proliferation ndash A Rare Case Report
罕見病例報告mdash青少年之淚阜非典型淋巴增生
施驊瑋 1林友祺 1
中文摘要
淚阜病灶相當罕見大部分為良性病灶眼睛及附屬結構淋巴增生疾病為其
鑑別診斷之一非常少見於年輕人或兒童我們報告一位 16歲的健康男性因
左眼淚阜無痛性腫塊接受切除手術卻於術後一個月復發執行第二次切除手術
後門診追蹤十個月未再復發此案例表現了部分良性與部分惡性腫瘤的特徵
我們針對反應性淋巴增生眼睛及附屬結構淋巴癌兩個疾病做討論及文獻回顧
關鍵字淚阜病灶眼睛及附屬結構淋巴增生疾病眼睛及附屬結構淋巴癌反
應性淋巴增生非典型淋巴增生
1 新光吳火獅紀念醫院眼科
通訊作者林友祺 電子信箱 yuchi067gmailcom
Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh 120
Submitted March 26 2020
Final version accepted April 16
2020
Case Report
Hyperacute intramembranous hemor-
rhage after burr hole craniostomy for
chronic subdural hematoma
Cite as Meng-Chi Lin Jui-Ming
Sun Yu-Hao Chen Cheng-Ta
Hsieh
Hyperacute intramembranous
hemorrhage after burr hole crani-
ostomy for chronic subdural he-
matoma Fu-Jen Journal of Medi-
cine 3(4) 120-125 2020
DOI
103966181020932020091803004
Meng-Chi Lin1 Jui-Ming Sun23 Yu-Hao Chen24 Cheng-Ta
Hsieh567
1Department of Surgery Zuoying Branch Kaohsiung Armed Forces
General Hospital Kaohsiung 813 Taiwan 2Section of Neurosurgery Department of Surgery Chia-Yi Christian
Hospital Chia-Yi City 600 Taiwan 3Department of Biotechnology Asia University Taichung City 41354
Taiwan 4Chung-Jen Junior College of Nursing Health Sciences and Manage-
ment Chia-Yi Country 62241 Taiwan 5Division of Neurosurgery Department of Surgery Sijhih Cathay Gen-
eral Hospital New Taipei City 22174 Taiwan 6Department of Medicine School of Medicine Fu Jen Catholic Univer-
sity New Taipei City 24205 Taiwan 7Department of Neurological Surgery Tri-Service General Hospital
National Defense Medical Center Taipei 114 Taiwan
Corresponding author E-mail address
nogormail2000comtw (Cheng-Ta Hsieh)
ABSTRACT
Burr hole craniostomy with closed-system drainage is an effective and common neurosurgical procedure to manage chronic subdural hematoma Postoperative hem-orrhage a well-known but infrequent complication may result in increased neurolog-ical deficits However hyperacute intramembranous hemorrhage within the inner and outer membrane of hematoma after burr hole craniostomy with irrigation and closed-system drainage has not been described previously Herein we report a case of postoperative spontaneous hyperacute intramembranous hemorrhage after burr hole craniostomy with closed-system drainage to manage a chronic subdural hematoma we subsequently discuss the possible pathophysiological mechanisms and review the relevant literature
Keywords Chronic subdural hematoma acute subdural hematoma bleeding burr hole craniostomy
drainage
Fu-J
Meng
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of Medicine V
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Vol 3 No 4 2
Acute intram
Yu-Hao Chen
CSDH) one ofuiring neurosugressive collechematomas in
outer and ievidence suggwith or wite and widely ut and that it ] Recurrence r this surgerywever the hyng after burr ely been discucase of a pa
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previous CS
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gure 3) No aface was obseealed an organn of fibroblasne Postoperaogical deficits
ISCUSSIO61-year-old won without regd been takingning Ganodermrs She was tment when shurological exasgow Coma S
muscle strengs was 45 on
ale Her laborh the normal rnoted Brain
n revealed Ch a marked m
ently she receniostomy withinage ring surgery mthe subdural sn of the duramatoma The arile saline throsed drainage swever this inm the subduraealed a hyperdural space fniostomy siteniotomy withthe hematom
morrhage was d inner membgure 3) No aface was obseealed an organn of fibroblasne Postoperaogical deficits
EFERENCRohde VComplicatiand closedsubdural analysis of
active bleedinerved Histolonized hematots and capilla
ative recoverywas gradual a
ON oman had a hi
gular medicatig nutritional ma lucidum referred to ohe became proxamination rScale ratings wgth score in th
the Medical ratory examinranges with nn computed
CSDH in the midline shift (ived one righth irrigation a
motor oilndashlikespace was uncal and outer marea was irrigaough the subdusystem was plcreased the rel space An emracute hemorrfrom the frone (Figure 2B
membranectma was perfo
only observebrane of theactive bleedinerved Histolonized hematots and capilla
ative recoverywas gradual a
CES V Graf Gons of burr-
d-system draihematomas
f 376 patient
ng from the ogical examinoma with prolaries in the m
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history of hypeion treatmentsupplements for more tha
our emergencyogressively drrevealed thatwere E1M5V2he left side ex
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(Figure 1) St parietal burrand closed-sy
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Vol 3 No 4 2
Acute intram
Yu-Hao Chen
vealing a layer
displaying a m
quent CT scan
em drainage (
rhage in the ri
2020
membranous
Cheng-Ta Hs
red type of CS
midline shift
ns (A) Bone w
(white arrow)
ight frontal re
hemorrhage
ieh
SDH (white ar
window view
and (B) Soft
gion (white ar
rrow) in the rig
showed the b
tissue windo
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ow showed hy
123
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Fu-J
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g-Chi Lin Ju
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(white arrow)
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Vol 3 No 4 2
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Yu-Hao Chen
o revealing ac
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2020
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cute intramem
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124
mem-
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Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh
125
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
慢性硬腦膜下出血進行鑽顱引流手術造成超急性夾膜內出
血
林孟楫 1孫瑞明 23陳昱豪 24謝政達 567
中文摘要
鑽顱併封閉系統引流手術是治療慢性硬腦膜下出血患者一種有效且常見的
神經外科手術方式術後出血可能導致神經功能缺損惡化是眾所周知但不常見
的併發症之一然而至今仍未有鑽孔併封閉系統引流造成原本慢性硬腦膜血
塊內膜和外膜間急性夾膜間出血案例在這裡我們報告一例慢性硬腦膜下出
血病患者接受鑽顱併封閉系統引流手術治療造成術後急性夾膜間出血我們在
本文中討論可能的致病機制並回顧相關文獻
關鍵字慢性硬腦膜下出血急性硬腦膜下出血出血鑽顱術引流
1國軍高雄總醫院左營分院 外科部
2崇仁醫護管理專科學校
3亞洲大學 生物科技學系
4戴德森醫療財團法人嘉義基督教醫院 外科部 神經外科
5汐止國泰綜合醫院 神經外科
6輔仁大學 醫學系
7 國防醫學院 三軍總醫院 神經外科
通訊作者謝政達 電子信箱 nogormail2000comtw
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
126
Submitted January 21 2020
Final version accepted July 08
2020
Case Report
Hamartoma of the breast A case report
Cite as Hsuan-An Chen
Cheng-Yu Lo Shih-Hung Huang
Chin-Lung Lin
Hamartoma of the breast A case
report Fu-Jen Journal of Medicine
3(5) 126-130 2020
DOI
103966181020932020091803005
Hsuan-An Chen1 Cheng-Yu Lo
3 Shih-Hung Huang
3 Chin-Lung
Lin2
1Department of Surgery Cathay General Hospital Taipei Taiwan
2Department of General Surgery Cathay General Hospital Taipei Tai-
wan
3Department of Pathology Cathay General Hospital Taipei Taiwan
Corresponding author E-mail address
lungyungmailcom (Chin-Lung Lin)
ABSTRACT
Breast hamartoma is an uncommon benign tumor rarely associated with malignancy An
excision and histological examination is necessary for the differential diagnosis We report
a case of a 49-year-old female patient presenting with a lump in the right breast Ultrasound
examination which demonstrated a 4411 cm hypoechoic lesion with lipoma Partial mas-
tectomy was arranged and the diagnosis of a hamartoma was confirmed by the histological
examination
Keywords Breast tumor Hamartoma Ultrasound
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
127
INTRODUCTION The hamartoma is a benign tumor-like lesion
that can affect various organs of the body in-
cluding lungs kidneys skin and more rarely the
breast In 1981 the hamartomas were recognized
in the WHO classification[1] They are defined
as well-demarcated mass of mammary ducts and
lobules containing varying amounts of fibrous
and adipose tissue and producing a distinctive
mammographic image
CASE REPORT A 49 year-old female had past history of left
breast mastitis with abscess status post partial
mastectomy This time she presented to our out
patient clinic for breast examination Physical
examination revealed a painless palpable mova-
ble and painless lump at upper outer quadrant of
right breast The risk of breast cancer was not
noted and the patient did not have any family
history of breast cancer The patient also denied
any trauma history before Ultrasound examina-
tion was arranged which demonstrated a 4411
cm hypoechoic lesion with lipoma at 3 oclock 2
cm from nipple of right breast and multiple hy-
poechoic nodules of various size in both breasts
and there was no suspicious axillary lymph
nodes noted (Figure1) Surgical treatment was
arranged partial mastectomy of right breast
harmartoma was successfully performed A 32 x
31 x 21 cm tumor was completely excised
Grossly examination showed a gray to yellow
and firm to fatty The diagnosis of a hamartoma
was confirmed by the histological examination
Microscopically sections of the breast lesion
show mammary hamartoma composed of ducts
lobules with interlobular fibrous tissue and adi-
pose tissue Fibrocystic change apocrine meta-
plastic ducts and scattered foci of adenosis are
noted The overall lobulocentric architecture and
the 2-cell pattern of the epithelium are preserved
columnar cell change and focal microcalcifica-
tion are present (Figure2) Based on submitted
biopsy specimen in-situ or invasive tumor cells
are not identified
DISCUSSION Hamartoma of the breast is a benign tumor like
nodule it was also known as fibroadenolipoma
lipofibroadenoma or adenolipoma based on its
predominant components It was composed of
varying amounts of glandular adipose and fi-
brous tissue[2] Hamartomas were first described
in 1971 by Arrigoni et al in a study of 10 patients
which breast tumors clinically and grossly re-
sembled fibroadenomas[3]
A higher predominance of tumors exists in fe-
males compared with males Hamartomas are
slowly-growing lesions with the diameter rang-
ing from 2 cm to 5 cm sometimes hamartomas
can reach giant diameter [4]
The clinical diagnosis of hamartoma is based on
the findings from mammography sonography
and histology examinations The hamartomas are
usually incidentally diagnosed by the women
older than 40 year-old starting mammography
screening
On physicial examination harmatomas are usu-
ally occult painless they may be as large mo-
bile soft to firm masses[5] Ultrasound showed
well capsulated mass with echogenic rim and
internal heterogeneity Mammography exam
showed well-circumscribed round to oval
masses containing fat and soft tissue densities
with a thin radiopaque pseudocapsule The
pseudocapsule results from displacement of
breast parenchyma by the tumor [56] In Pa-
thology finding microglandular adenosis is pre-
sent in fibroadipose stroma surrounded by a thin
fibrous capsule It composed of a combination of
epithelial and stromal elements usually with
normal ducts or lobules although variations of
normal tissue may also be seen Fibroadenoli-
poma myoid hamartoma and chondrolipoma are
histological variations of hamartomas depend-
ing on the proportion of normal breast tissue
elements[7]
Malignancy associated with hamartomas are
very rare[8] However it has been reported
hamartomas develop into carcinoma Malignant
transformation can occur as a result of cellular
atypia in the epithelial component of the mass[9]
Surgical removal is the curative method for
breast hamartomas[10] Diagnostic material such
as mammography ultrasonography or core nee-
dle biopsy may not give the definitive diagnosis
Therefore surgical excision and histological
examination is necessary for differential diagno-
sis[111213]
Although it is rare hamartoma can be seen along
with malignancy as it is formed from similar
components of breast tissue Therefore careful
diagnosis and appropriate management including
surgery are required
REFERENCES 1 World Health Organization (1981)
Histological typing of breast tumors In
International histological classification of
tumors 1981 2nd ed
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
128
2 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11435ndash449
2006
3 ArrigoniMG DockertyMB JuddES
The identificationand treatment of
mammary hamartoma Surg Gynecol
Obstet1971 133 577-82
4 Sanal HT Ersoz N Altinel O Unal E Can
C Giant hamartoma of the breast Breast J
2006 12 84-85
5 Feder JM de Paredes ES Hogge JP
Wilken JJ Unusual breast lesions
radiologic-pathologic correlation
Radiographics 1999 19S11ndashS26
6 Murat A Ozdemir H Yildirim H Poyraz
AK Ozercan R Hamartoma of the breast
Australas Radiol 200751 Spec NoB37ndash
9
7 Fisher CJ Hanby AM Robinson L Millis
RR Mammary hamartoma-a review of 35
cases Histopathology 1992 20 99-106
8 Choi N Ko ES Invasive ductal carcinoma
in a mammary hamartoma case report and
review of the literature Korean J Radiol
2010 Nov-Dec11(6)687-91
9 Lee EH Wylie EJ Bourke AG Bastiaan
De Boer W Invasive ductal carcinoma
arising in a breast hamartoma two case
reports and a review of the literature Clin
Radiol 2003 58 80-3
10 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11 435 ‑449
2006
11 Coyne J Hobbs FM Boggis C Harland R
Lobular carcinoma in a mammary
hamartoma J Clin Pathol 199245936ndash
937
12 G M K Tse B K B Law T K F Ma A B W
Chan Hamartoma of the breast a
clinicopathological review J Clin Pathol
200255951ndash954
13 RAAmir SSheikh BreasthamartomaA
report of 14cases of an under-recognized
and under-reported entity International
Journal of Surgery Case Reports
22(2016)1ndash4
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
129
FIGURES
Figure 1 Ultrasound shows a 4411 cm hypoechoic lesion with lipoma at 3 oclock 2 cm from nipple
of right breast
Figure 2 Photomicrograph shows mammary hamartoma composed of ducts lobules with interlobular
fibrous tissue and adipose tissue
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
130
Hamartoma of the breast A case report
乳房錯構瘤罕見個案報告
陳宣安 1羅承裕 3黃世鴻 3林錦龍 2
中文摘要
乳房錯構瘤是一種罕見之乳房良性腫瘤切除手術及病理化驗來做鑑別診斷
我們報告一位 49歲女性以可觸摸到無痛性右側乳房腫塊為臨床表徵超音波
看到一個邊緣清楚低迴音的腫塊病患接受手術切除病灶病理診斷證實為乳
房錯構瘤
關鍵字乳房腫瘤錯構瘤超音波攝影
1國泰綜合醫院外科部
2國泰綜合醫院一般外科
3國泰綜合醫院病理科
通訊作者林錦龍 電子信箱 lungyungmailcom
Fu-Jen Journal of Medicine
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Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang
99
Submitted October 11 2019
Final version accepted February
02 2020
Original Research Article
Human Factors Underlying Adverse
Medical Events Revisit Root Cause Anal-
ysis Cases Using the HFACS
Cite as Yu-Hsun Cheng
Sheng-Hui Hung Tung-Wen Ko
Pa-Chun Wang
Human Factors Underlying Ad-
verse Medical Events Revisit
Root Cause Analysis Cases Using
the HFACS Fu-Jen Journal of
Medicine 3(2) 99-111 2020
DOI
103966181020932020091803002
Yu-Hsun Cheng1 Sheng-Hui Hung
12 Tung-Wen Ko
3 Pa-Chun
Wang14
1Department of Quality Management Cathay General Hospital Taipei
Taiwan
2Institute of Health Policy and Management National Taiwan Universi-
ty Taipei Taiwan
3Center for Healthcare Quality Management Cheng Hsin General Hos-
pital Taipei Taiwan
4Fu Jen Catholic University School of Medicine New Taipei City Tai-
wan
Corresponding author E-mail address
drtonyseednettw (Pa-Chun Wang)
ABSTRACT Background Appropriate management of adverse medical events (AMEs) is the corner-
stone of patient safety Root cause analysis (RCA) is used to investigate serious or
high-frequency errors but is limited by its inability to explain a broader scope of factors
We re-reviewed RCA cases to understand the underlying human organizational or system-
ic factors affecting AMEs Methods A total of 40 consecutive RCA cases (2012-2016) were
retrieved from the AMEs database A panel was organized to retrospectively re-review these
cases using the Human Factor Analysis and Classification System HFACS Results For
active failures errors stemmed largely from performance-based (95) judgment and deci-
sion-making errors (875) Incorrectly followed procedures (816) and accidental
equipment operation (50) were the most common types of performance-based errors In-
adequate real-time assessment (686) and inappropriate operative actions (686) were
the most common decision-making errors For sources of latent failure teamwork problems
(275) including failure to effectively communicate (818) and communicate critical
information (727) were common Inadequate supervision (929) or command over-
sights (929) were the most common problems related to inadequate supervision (35)
Organizational programpolicy risks not adequately assessed (50) were the most common
problems related to policy and process problem (25) Conclusions The HFACS review
enhances our understanding of human factors underlying AMEs The HFACS reveals latent
supervisory organizational or systematic problems that cannot be addressed through tradi-
tional RCA Keywords patient safety adverse events root cause analysis human factors
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 100
INTRODUCTION Patient safety involves the reduction of patient
harm from potentially avoidable unintended
outcomes [1] Studies have revealed that 50ndash
80 of adverse medical events (AMEs) are pre-
ventable [2-4] to eliminate such errors the ap-
propriate management of AMEs hence repre-
sents the cornerstone of patient safety work
Through incident reporting investigation and
analysis healthcare providers can correct or
re-engineer their care processes to prevent inci-
dent recurrence [25] One of the most popular
tools for investigating AMEs is root cause anal-
ysis (RCA) RCA reconstructs a chain of errors
to identify the deviation of care from normal
processes Nonetheless with a lack of standard-
ized nomenclature and investigation procedures
RCA report conclusions are sometimes too sub-
jective and nonspecific to facilitate any actiona-
ble safety improvement plans [5-7] According
to the UK Health and Safety Executive defini-
tion human factors are environmental organiza-
tional occupational or individual human char-
acteristics which influence behavior at work
such that health and safety are affected [8] Hu-
mans and systems are prone to errors and stud-
ies have showed that nearly 70 of medical
errors involve human factors [2-4] Reasonrsquos
Swiss cheese model described the penetration of
causative human errors through layers of defen-
sive barriers leading to system collapse [9]
With much focus on the temporal sequence and
severity of departure from accepted practices in
an incident the effectiveness of RCA is often
challenged by its incapability of exploring un-
derlying human organization or even systemic
factors [5-7] Reason and others have proposed
that errors can occur at 4 levels 1) unsafe acts
(operator actions) 2) preconditions for unsafe
acts (environmental factors contributing to er-
rors) 3) inadequate supervision (management
actions affecting the operator) and 4) organiza-
tional influences (organizational culture policies
and procedures that affect the operator) [9]
Based on this theory Wiegmann and Shappell
developed the Human Factor Analysis Classifi-
cation System (HFACS) to describe human fac-
tors causing accidents from 4 tiers of categories
Each of these categories consists of nanocodes to
represent specific human behavior or system
problems leading to errors [9-10] The tier for
unsafe acts involves actual provider actions (er-
rors or rule violations) directly leading to events
The tier representing preconditions for unsafe
acts includes operational personnel and envi-
ronmental factors The supervision tier addresses
leadership problems operational planning fail-
ure or correction and supervisory ethics The
tier for organizational influences deals with re-
source management organizational climate and
operational processes (Supplement Table 1) The
HFACS provides standardized investigation
processes for the systematic analysis of common
causes of adverse events across national defense
nuclear power navy aviation and healthcare
industries Taiwan launched its nationwide
AME-reporting system the Taiwan Patient
Safety Reporting System (TPR) in 2004 RCA
methodology was subsequently introduced to the
healthcare industry by the Joint Commission of
Taiwan [11] Since 2012 appropriate manage-
ment of AMEs has been listed as a national pa-
tient safety goal [12] RCA is required by the
Ministry of Health and Welfare for major AMEs
Aside from RCA a comprehensive structural
reliable and valid framework is urgently re-
quired to further guide organizational or even
national patient safety policies In this study we
used the HFACS to review our RCA cases aim-
ing to investigate human factors underlying se-
vere or frequent AMEs
MATERIALS AND METHODS Through continuous sampling 40 consecutive
RCA cases (2012-2016) were retrieved from a
hospitalrsquos (Cathay General Hospital Taipei
Taiwan) AME-reporting system database The
database contains AMEs relating to areas such as
medication patient falls surgery transfusion
clinical care public accidents security hospital
violence tube-related complication unplanned
cardiopulmonary resuscitation laboratory testing
and examination and anesthesia The RCA cases
were sentinel or high-frequency events classified
according to severity assessment category (SAC)
[1113] The SAC is an evaluation method for
categorizing AMEs by severity of effect on pa-
tients health and risk of incident reoccurrence
The HFACS has been modified (from the US
Department of Defense version 70) and trans-
lated into Mandarin Chinese with authorization
from the original developers [10] The Chi-
nese-version HFACS for Taiwan is a valid in-
strument (content validity index 09 Cronbachrsquos
α gt07 interrater reliability Κ 04-10) equiva-
lent to the original English version [9] The
HFACS contains 4 tiers 13 subitems and 109
nanocodes (Supplement Table 1) A panel of 6
reviewers was established All reviewers were
from clinical or management (quality and patient
safety management) backgrounds Reviewers all
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 101
finished human factor education and were
trained to use the HFACS through a consensus
meeting Each RCA case was randomly assigned
to 2 reviewers Human factors leading to partic-
ular AMEs were identified and confirmed when
2 reviewers reached agreement The distribution
of errors among tiers subitems and nanocodes
are provided with descriptive statistics () The
study was approved by the Institutional Review
Board of Cathay General Hospital
(CGH-P105095)
RESULTS AMEs related to laboratory testing and examina-
tion (n = 16) clinical care (n = 9) and medica-
tion (n = 7) were the most commonly observed
in the RCA Most AMEs in this cohort are
ranked as being SAC level 3 (n = 15) or 4 (n =
17) (Table 1)
Acts (Active Failures)
This tier of errors contains 3 subitems and 13
nanocodes In the 40 RCA cases perfor-
mance-based errors for 38 (95) and judgment
and decision-making errors for 35 (875) com-
prised the most common error types with viola-
tion for 6 (15) less common Procedure fol-
lowed incorrectly for 31 out of 38 (816) was
the most common performance-based problem
Inadequate real-time risk management for 24 out
of 35 (686) was the most common judgment
or decision error All of the rule violations were
workaround types for 6 out of 6 (100) (Figure
1)
Preconditions(Latent Failures)
This tier of errors has 9 subitems and 58 nano-
codes In the 40 RCA cases teamwork for 11
(275) and environmental for 8 (20) factors
contributed to most of the errors with mental
and physical state the next most common factor
for 7 (175) Communication for 9 out of 11
(818) and information relay for 8 out of 11
(727) were the most common issues related to
teamwork Few contributors mentioned failures
related to technical errors for 4 (50) or physi-
cal for 1 (125) environment Not paying at-
tention for 4 out of 7 (571) and negative habit
transfer for 4 out of 7 (571) were common
mental contributes noted for 7 (100) Overcon-
fidence was the most common problem related
to emotional status for 4 out of 7 (571) Fa-
tigue was observed in only 2 cases for 2 out of 2
physical problems (100) (Figure 2)
Supervision(Direct Supervisory Chain of
Command)
This tier of errors contains 3 subitems and 17
nanocodes In the 40 RCA cases inadequate
supervision for 14 (35) and inappropriately
planned operations for 11 (275) factors con-
tributed to most of the respective errors fol-
lowed by supervisory violations for 7 (175)
Supervisory or command oversights for 13 out
of 14 (929) were the most common sources of
supervision inadequacy Authorized unnecessary
hazards for 7 out of 11 (636) were the most
common inappropriately planned operations
Failure to enforce rules for 6 out of 7 (857)
was the most common supervisory violation
(Figure 3)
Organization Influence (Upper-Level Man-
agement)
This tier of errors contains 4 subitems and 18
nanocodes In the 40 RCA cases policy and
process issues for 10 (25) and resources prob-
lem for 8 (20) were major concerns Few of
the respective problems are related to climate
and cultural influences for 2 (5) or to person-
nel selection and staffing for 1 (25) Poorly
assessed organizational programs or policy risks
for 5 out of 10 (50) were the most common
policy and process problems Failure to provide
adequate operational information resources for 4
out of 8 (50) and command and control re-
source deficiency for 3 out of 8 (375) were
the main resource management problems Little
was revealed regarding organizational climate
and culture (n = 1 out of 2 50) or staffing for 1
out of 1 (100) (Figure 4)
DISCUSSION Health care is a complex system comprising
many high-reliability organizations (HROs) The
vulnerability of HROs stems from the participa-
tion of multidisciplinary teams in the processes
along a variety of patient care timelines How-
ever humans and systems are inherently prone
to errors the appropriate management of AMEs
is acknowledged to be the cornerstone of patient
safety AMEs should be reported investigated
analyzed and handled appropriately[14] Theo-
retically by analyzing the pattern of key defects
providers can fix errors and re-engineer their
care processes to reduce the possibility of AME
recurrence Taiwan established its nationwide
TPR in 2004 so far 7000 health care facilities
have participated and the database has accumu-
lated more than 055 million AMEs[11] Infor-
mation generated from the TPR database can
improve patient safety at individual organiza-
tional or even national levels However despite
relentless efforts few substantial improvements
have been achieved in patient safety [15-17]
Since its introduction in Taiwan in 2006 the use
of RCA for AMEs has encountered some diffi-
culties 1) No structural and standardized
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 102
framework exists for investigation
cross-institution variability and interrater relia-
bility are often ignored 2) Conclusions are often
subjective and corrective recommendations are
less actionable relying on individual reviewersrsquo
professional backgrounds and their experiences
3) Much focus on event reconstruction and oper-
ator performance means that factors relating to
human behavior organizational culture and
system weakness are not comprehensively ad-
dressed [671718] Traditionally attempts to
improve patient safety in the health care industry
are largely reactive in nature identifying and
correcting errors in care processes [1920]
Causes of defects are not thoroughly understood
Proactive approaches must be taken to address
systematic problems within a complex system
[720] Research suggests that human error is a
causal factor in the occurrence of AMEs AME
investigation targets have moved from skill defi-
ciency toward decision-making attitudes super-
visory factors and even organizational climate
or culture HFACS methodology is based on the
Swiss cheese model that also emphasizes active
and latent failures [921] The study provides
some noteworthy findings First most AMEs as
expected involve active failures such as failure
to follow procedure accidental operation of
equipment inadequate real-time risk manage-
ment and inappropriate action These are all
sharp ends in classic RCA environment physi-
cal and mental factors are less prevalent This
proves that retrospectively determining addi-
tional causal factors is difficult when infor-
mation has not been collected during preliminary
investigation (Figure 1) Second team-
work-related problems particularly in relation to
communication and information relay are well
addressed This may be attributed to the dec-
ade-long institution-wide routine crew resource
management training in the respective research
hospital (Figure 2) Third the HFACS success-
fully reflects the importance of supervisory roles
in the occurrence of AMEs and this cannot be
overlooked (Figure 3) Fourth latent failures
especially in organizational climate or cultural
dimensions have been less frequently addressed
in incident reports a limitation of traditional
RCA However the HFACS review suggests
room for improvement in resource allocation and
policy modification within the hospital The
results of studies can make the organization
think about how to improve the patient safety
and management process from the perspective of
human factors such as improving the comfort of
the working environment and replacing and
equipment resources to prevent personnel from
affecting the medical quality and patient safety
due to the environment or equipment Need to
appropriate assessment of applicability and ade-
quate training of manpower is required The
management and control of risks should be fully
evaluate and grasp resource management and
leaders need to participate in and promote medi-
cal quality and patient safety activities to en-
hance its culture (Figure 4) No panacea exists
to ensure patient safety and improvement targets
originate largely from event investigation find-
ings Unfortunately factors identified from
AMEs are often self-explanatory with little value
for further action correction Reinforcement of
policy or processes redundant education or
repetitious training are formulaic overprescribed
RCA recommendations The use of HFACS in
this study proves that a structural prospective
AME investigation format can potentially help
with proactive patient safety management We
suggest developing an interview guideline for
the routine use of HFACS as a complement to
RCA in every AME investigation This study is a
retrospective study The underlying human fac-
tors can be under-estimated owing to the lack of
related information in the original RCA reports
CONCLUSION The HFACS review in this study enhances our
understanding of human factors in AMEs that
had previously been insufficiently scrutinized
Aside from active process and communication
errors the HFACS enables the prospective in-
vestigation of latent supervisory organizational
or systematic problems that cannot be addressed
through traditional RCA
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Incidence of adverse events and
negligence in hospitalized patients results
of the Harvard Medical Practice Study I N
Engl J Med 1991324370-376
2 Wang CH Shih CL Chen WJ et al
Epidemiology of medical adverse events
perspectives from a single institute in
Taiwan J Formos Med Assoc
2016115434-439
3 Vincent C Simon R Sutcliffe K et al
Errors Conference Executive Summary
Acad Emerg Med 200071180-1182
4 Taitz J Genn K Brooks V et al
System-wide learning from root cause
analysis A report from the New South
Wales Root Cause Analysis Review
Committee Qual Saf Health Care
2010191-5
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 103
5 Hutchinson A Young TA Cooper KL et
al Trends in healthcare incident reporting
and relationship to safety and quality data
in acute hospitals results from the
National Reporting and Learning System
Qual Saf Health Care 2009185-10
6 Mitchell RJ Williamson AM Molesworth
B et al A review of the use of human
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in the hospital setting Ergonomics
2014571443-1472
7 Gurses AP Ozok AA Pronovost PJ Time
to accelerate integration of human factors
and ergonomics in patient safety BMJ
Qual Saf 201221347-351
8 Health and Safety Executive Introduction
to human factors
httpwwwhsegovukhumanfactorsintro
ductionhtm
9 Wiegmann DA Shappell SA A human
error approach to aviation accident
analysis The human factors analysis and
classification system Burlington VT
Ashgate Publishing Ltd 2003
10 Yu-Hsun Cheng Sheng-Hui Hung
Tung-Wen Ko et al An Analysis of the
Reliability and Validity of Human Factors
Analysis Classification System in Medical
Adverse Events Journal of Healthcare
Quality 20191370-76
11 Taiwan Joint Commission on Hospital
Accreditation Taiwan Patient-Safety
Reporting System Annual Report 2017
New Taipei City Taiwan
12 Taiwan Patient Safety Net
httpwwwpatientsafetymohwgovtwCo
ntentzMessagesslistaspxSiteID=1ampMm
mID=621273300317401756
13 Government of Western Australia
Department of Health
httpsww2healthwagovauArticlesS_T
Severity-assessment-codes
14 Farley DO Haviland A Champagne S et
al Adverse-event-reporting practices by
US hospitals results of a national survey
Qual Saf Health Care 200817416-423
15 Shojania KG Thomas EJ Trends in
adverse events over time why are we not
improving BMJ Qual Saf
201322273-277
16 Levitt P Challenging the systems approach
why adverse event rates are not improving
BMJ Qual Saf 2014231051-1052
17 Kellogg KM Hettinger Z Shah M et al
Our current approach to root cause
analysis is it contributing to our failure to
improve patient safety BMJ Qual Saf
201726381-387
18 Khorsandi M Skouras C Beatson K et al
Quality review of an adverse incident
reporting system and root cause analysis of
serious adverse surgical incidents in a
teaching hospital of Scotland Patient Saf
Surg 2012621
19 Diller T Helmrich G Dunning S et al
The Human Factors Analysis
Classification System (HFACS) Applied to
Health Care Am J Med Qual
201429181-190
20 Carayon P Xie A Kianfar S Human
factors and ergonomics as a patient safety
practice BMJ Qual Saf 201423196-205
21 Reason J Human Error New York
Cambridge University Press 1990
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 104
TABLE
Table 1 Incidences by Category (N=40)
CategorySAC SAC 4 SAC 3 SAC 2 SAC 1 total
Laboratory and ex-
amination events
4 10 2 0 16 (400)
Clinical care event 6 2 1 0 9 (225)
Medication event 5 0 2 0 7 (175)
Surgery-related event 1 1 2 0 4 (100)
Transfusion-related
event
1 1 0 0 2 (50)
Tube event 0 1 0 0 1 (25)
Public accident 0 0 1 0 1 (26)
Total 17 (425) 15 (375) 8 (200) 0 40 (100)
SAC 1113 Severity Assessment Code SAC
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 105
FIGURES
Figure 1 Active Failures (N=40)
16 (167)
66 (1000)
640 (150)
235 (57)
735 (200)
2435 (686)
2435 (686)
3540 (875)
438 (105)
438 (105)
738 (184)
1938 (500)
3138 (816)
3840 (950)
0 5 10 15 20 25 30 35 40
Commits WidespreadRoutine Violation
Performs Work-Around Violation
Ignored a CautionWarning
Failure to Prioritize Tasks Adequately
Wrong Choice of Action During an Operation
Inadequate Real‐Time Risk Assessment
Rushed or Delayed a Necessary Action
Breakdown in Visual Scan
Over-ControlledUnder-Controlled AircraftVehicleSystem
Unintended Operation of Equipment
Procedure Not Followed Correctly
Performance-Based Errors
Judgment and Decision Making Errors
Violations
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 106
Figure 2 Preconditions (Latent Failures or Conditions) (N=40)
14 (250)
24 (500)
48 (500)
11 (1000)
18 (125)
840 (200)
0 5 10 15 20 25 30 35 40
Seat and Restraint System Problems
Instrumentation amp Warning System Issues
Noise Interference
Environment
Physical Environment
Technological Environment
27 (286)
27 (286)
27 (286)
37 (129)
47 (511)
47 (571)
77 (1000)
24 (500)
44 (1000)
47 (571)
12 (500)
22 (1000)
27 (286)
740 (175)
0 5 10 15 20 25 30 35 40
Technical or Procedural Knowledge Not Retained After Training
InterferenceInterruption
Task OverUnder Saturation
Distraction
Negative Habit Transfer
Not Paying Attention
Complacency
Overconfidence
Physical IllnessInjury
Fatigue
Physical and Mental State
Physical Problem
State of Mind
Mental Awareness
211 (182)
311 (273)
311 (273)
411 (364)
811 (7227)
911 (818)
1140 (275)
0 5 10 15 20 25 30 35 40
Inadequate Task Delegation
TaskMission PlanningBriefingDebriefing Inadequate
Failure of CrewTeam Leadership
StandardProper Terminology Not Used
Critical Information Not Communicated
Failed to Effectively Communicate
Teamwork
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 107
Figure 3 Supervision (Direct Supervisory Chain of Command) (N=40)
Figure 4 Organization Influence (Upper-Level Management Command Level) (N=40)
114 (71)
114 (71)
214 (143)
314 (214)
1314 (929)
1440 (350)
511 (455)
511 (455)
711 (636)
1140 (275)
47 (571)
67 (857)
740 (175)
0 5 10 15 20 25 30 35 40
Selected Individual with Lack of Proficiency
Improper Role‐modeling
Failed to Provide Proper Training
Failed to IdentifyCorrect Risky or Unsafe Practices
SupervisoryCommand Oversight Inadequate
Performed Inadequate Risk Assessment ‐Formal
Selected Individual with Lack of Current or Limited Experience
Authorized Unnecessary Hazard
Allowing Unwritten Policies to Become Standard
Failure to Enforce Existing Rules
Supervisory Violations
Planned Inappropriate Operations
Inadequate Supervision
12 (500)
12 (500)
240 (50)
110 (100)
510 (500)
1040 (250)
11 (1000)
140 (25)
18 (125)
18 (125)
38 (35)
48 (500)
840 (200)
0 5 10 15 20 25 30 35 40
Organizational Over-confidence or Under-confidence in Equipment
Organizational Culture (attitude actions) Allows for Unsafe TaskMission
Purchasing or Providing Poorly Designed or Unsuitable Equipment
Organizational ProgramPolicy Risks not Adequately Assessed
Failure to Provide Adequate Manning Staffing Resources
Failure to remove inadequate worn-out equipment in timely manner
Inadequate infrastructure
Command and control resources are deficient
Failure to provide adequate operational information resources
Resource Problems
Personnel Selection amp Staffing
Policy and Process Issues
ClimateCulture Influences
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 108
Supplement Table 1- HFACS Content of Human Factor Analysis Classifi-
cation System [9] Tier main level sub-item nano code
Tier 1 Unsafe Acts
Perfor-
mance-Based
Errors
Unintended operation of equipment
Checklist not followed correctly
Procedure not followed correctly
Over-controlledunder-controlled aircraftvehiclesystem
Breakdown in visual scan
Rushed or delayed a necessary action
Judgment amp De-
cision-Making
Errors
Inadequate real‐time risk assessment
Failure to prioritize tasks adequately
Ignored a cautionwarning
Wrong choice of action during an operation
Violations
Performs work-around violation
Commits widespreadroutine violation
Extreme violation-lack of discipline
Tier 2 Preconditions
Environment
Physical environment
Environmental conditions affecting vision
Vibration effects vision or balance
Heatcold stress impairs performance
External force of object impeded an individualrsquos
movement
Lights of other vehiclevesselaircraft affected vision
Noise interference
Technological environment
Seat and restraint system problems
Instrumentation amp warning system issues
Visibility restrictions (not weather related)
Controls and switches are inadequate
Automated system creates unsafe situation
Workspace incompatible with operation
Personal equipment interference
Communication equipment inadequate
Physical and
Mental State
Physical problem
Substance effects (alcohol supplements medications
drugs)
Loss of consciousness (sudden or prolonged onset)
Physical illnessinjury
Fatigue
Inadequate adaptation to darkness
Dehydration
Body sizemovement limitations
Physical strength amp coordination (inappropriate for
task demands)
Nutritiondiet
State of mind
Psychological problem
Life stressors
Emotional state
Personality style
Overconfidence
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 109
Pressing
Complacency
Motivation
Motivational exhaustion (burnout)
Sensory misperception
Motion illusion-kinesthetic
Turning illusionbalance-vestibular
Visual illusion
Misperception of changing environment
Misinterpreted misread instrument
Misinterpretation of auditorysound cues
Spatial disorientation
Temporaltime distortion
Mental awareness
Not paying attention
Fixation
Task overunder saturation
Confusion
Negative habit transfer
Distraction
Geographically lost
Interferenceinterruption
Technical or procedural knowledge not retained after
training
Inaccurate expectation
Teamwork
Failure of crewteam leadership
Inadequate task delegation
Rankposition intimidation
Lack of assertiveness
Critical information not communicated
Standardproper terminology not used
Failed to effectively communicate
Taskmission planningbriefingdebriefing inadequate
Tier 3 Supervision
Supervisory Vio-
lations
Failure to enforce existing rules
Allowing unwritten policies to become standard
Directed individual to violate existing regulations
Authorized unqualified individuals for task
Planned Inappro-
priate Operations
Directed task beyond personnel capabilities
Inappropriate team composition
Selected individual with lack of current or limited experience
Performed inadequate risk assessment ‐formal
Authorized unnecessary hazard
Inadequate Su-
pervision
Supervisorycommand oversight inadequate
Improper role‐modeling
Failed to provide proper training
Failed to provide appropriate policyguidance
Personality conflict with supervisor
Lack of supervisory responses to critical information
Failed to identifycorrect risky or unsafe practices
Selected individual with lack of proficiency
Tier 4 Organizational
Influences
Resource Prob-
lems
Command and control resources are deficient
Inadequate infrastructure
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 110
Failure to remove inadequate worn-out equipment in timely
manner
Failure to provide adequate operational information resources
Fail to provide adequate funding
Personnel Selec-
tion amp Staffing
Personnel recruiting amp selection policies are inadequate
Failure to provide adequate manning staffing resources
Policy amp Process
Issues
Pace of ops-tempoworkload
Organizational programpolicy risks not adequately assessed
Provided inadequate procedural guidance or publications
Organizational (formal) training is inadequate or unavailable
Flawed doctrinephilosophy
Inadequate program management
Purchasing or providing poorly designed or unsuitable equip-
ment
ClimateCulture
Influences
Organizational culture (attitude actions) allows for unsafe
taskmission
Organizational over-confidence or under-confidence in equip-
ment
Unit missionaircraftvehicleequipment change or unit deacti-
vation
Organizational structure is unclear or inadequate
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 111
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
以 HFACS重新檢視根本原因分析案例挖掘造成醫療不良
事件之人為因素
鄭伃洵 1洪聖惠 12柯彤文 3王拔群 14
中文摘要
背景醫療不良事件(AMEs)的管理是促進病人安全的基石根本原因分析
(RCA)是探討重大病人安全不良事件問題但是由於無法解釋更廣泛的因素而受
到限制本研究使用人為因素分類與分析工具(HFACS)回溯審視醫療不良事件
以了解影響醫療不良事件的人為因素及各層面中錯誤原因之分佈或系統性問題
方法本研究回溯 2012-2016年間有做過根本原因分析之醫療不良事件以連續
性取樣方式(continuous sampling)收集 40例醫療不良事件以人為因素分類與分
析工具(HFACS)去系統性的挖掘每件案例發生錯誤之原因結果在行為層面中
分析結果主要為基礎技能錯誤(95)判斷和決策錯誤(875)其中在基礎技能
錯誤當中以未依程序作業執行(816)及未如預期設備操作(50)佔多數判斷和
決策錯誤中以現場風險評估不確實(686)及採取錯的步驟行為(686)佔多數
而在先決條件層面中以團隊合作(275)為主要因素包含溝通不良(818)及重
要訊息未以正確的方式即時傳達(727)佔多數在監督層面當中以監督不周
(929)或監督不妥當(929)為主要因素在組織政策和流程方面(50)以組織
系統的政策風險未充分評估(35)為主要因素結論本研究進一步了解醫療不
良事件在過去使用根本原因分析未探討到的人為因素反映出潛在的監督組織
行為或系統性的問題促進病人安全預防錯誤再發生
關鍵字病人安全醫療不良事件根本原因分析人為因素
1國泰醫療財團法人國泰綜合醫院 品質管理部
2國立臺灣大學健康政策與管理研究所
3振興醫療財團法人振興醫院 醫療品質管理中心
4輔仁大學醫學院
通訊作者王拔群 電子信箱 drtonyseednettw
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin 112
Submitted January 20 2020
Final version accepted April13
2020
Case Report
Juvenile Caruncular Atypical Lymphoid
Proliferation ndash A Rare Case Report
Cite as Hua-Wei Shih Yu-Chi Lin
Juvenile Caruncular Atypical
Lymphoid Proliferation ndash A Rare
Case Report Fu-Jen Journal of
Medicine 3(3) 112-119 2020
DOI
103966181020932020091803003
Hua-Wei Shih1 Yu-Chi Lin
1
1Department of Ophthalmology Shin Kong Wu Ho-Su Memorial Hos-
pital Taipei City Taiwan
Corresponding author E-mail address
yuchi067gmailcom (Yu-Chi Lin)
ABSTRACT
Lesions of the caruncle are very rare Most caruncular lesions are benign though there were still few reported malignant lesions Ocular adnexal lymphoproliferative disease (OALD) one of the differential diagnosis of caruncular lesion is seldom seen in young pa-tient In this article we report a 16-year-old boy with recurrent caruncular atypical lym-phoid proliferation We discuss the epidemiology clinical features images histomorpholo-gy and treatment between ocular adnexal lymphomas (OAL) and reactive lymphoid hyper-plasia (RLH)
Keywords caruncular lesion ocular adnexal lymphoproliferative disease ocular adnexal lymphoma
reactive lymphoid hyperplasia atypical lymphoid proliferation
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
113
INTRODUCTION Lesions of the caruncle are very rare Differen-
tial diagnosis includes nevus myeloproliferative
disorders tumors inflammation infection cysts
vascular lesions and fibrous Biopsy is essential
for diagnosis Levy J et al reported ocular ad-
nexal lymphoproliferative disease (OALD) was
relatively uncommon diagnosis among caruncu-
lar lesions [1]
OALD was seldom described in Asian popula-
tion especially for young age C-Y Cheng re-
ported age-standardized incidence of ocular
adnexal lymphomas (OAL) in Taiwan from 1979
to 1996 was below 07 per million per year and
mean age was 531 years old [2] In 2015 five
Taiwanese cases of OAL whose age ranging
from 45 to 64 were presented [3] However
there were few cases of conjunctival OAL or
RLH in Chinese pediatric patient
Here we present a case of 16-year-old boy with a
caruncular mass at his left eye with recurrence
one month after excision We describe his clini-
cal symptoms photographs pathological results
management and follow-up clinical course in
this report
CASE REPORT A 16-year-old healthy boy presented a mass
lesion at his left eye caruncle accompanied with
the symptom of tearing for one month (Figure 1)
He had no ocular pain no itchiness no blurred
vision no night sweating no fever and no body
weight loss The patient denied systemic diseas-
es and histories of surgery His bilateral best
corrected visual acuity (BCVA) were 66 and
intraocular pressure (IOP) were both within
normal range There were no remarkable find-
ings for his cornea lens fundus and physical
examination Excision was performed and the
mass was soft with fluid inside therefore con-
junctival pyogenic cyst was our initial diagnosis
However one month after the excision a pro-
truding mass recurred at the patientrsquos nasal can-
thus of left eye (Figure 2) There were some
differences compared to previous condition At
the first time the soft mass was contained in a
well-defined cyst wall which more favored py-
ogenic granulation However after short period
of recurrence solid consistency and unclear
margin were found which favored malignancy
Besides the mass partially involved beyond the
gray line of nasal part lower eyelid whereas last
time the cyst mainly extended from conjunctiva
of caruncle The second excisional biopsy was
performed Pathologic examination demonstrat-
ed abundant atypical lymphoid proliferation
(Figure 3A 3B) Immunohistochemical studies
showed that the lymphoid aggregation was
composed predominantly of CD20-positive cells
(Figure 3C) focal positive staining of CD3
(Figure 3D) CD5 CD23 CD10 and negative
staining of cyclin-D1 Unfortunately the cellular
morphology was difficult to be evaluated due to
marked crushing artifact Thus malignant lym-
phoma cannot be excluded totally
Orbital computed tomography (CT) showed a
lesion of soft tissue density at medial canthus of
left orbit without obvious nasolacrimal duct or
bony invasion (Figure 4A) Magnetic resonance
imaging (MRI) with contrast showed strong
enhancement at left medial canthus region (Fig-
ure 4B) There was no remarkable finding in the
systemic workup including complete blood
count and differential count biochemical pro-
files and 18F-fluoro-2-deoxyglucose positron
emission tomographycomputed tomography
(18F-FDG PETCT) indicating no evidence of
systemic involvement
After the second excision we preferred con-
servative management for him due to the uncer-
tainty of malignancy and to avoid side effects
from aggressive treatment No sign of recurrence
was noted after 10 months of observation The
follow-up photo was taken at three months after
the second operation (Figure 5)
DISCUSSION Ocular adnexal lymphoproliferative disease
(OALD) consists of the spectrum of lymphoid
disease affecting the tissues surrounding the eye
including ocular adnexal lymphomas (OAL) and
lymphoid hyperplasia (LH) [4] The conjunctiva
is an important location for extranodal lympho-
ma development which comprises 25 of OAL
[5]
OAL can be grouped into two categories based
on their appearance of cells under the micro-
scope low-grade and high-grade [6] Extranodal
marginal zone lymphoma of mucosa-associated
lymphoid tissue (EMZLMALT) is the most
common subtype of OAL followed by follicular
lymphoma [7-9] Both of the above are
low-grade lymphomas
LH can be further divided by histopathology into
reactive lymphoid hyperplasia (RLH) and atypi-
cal lymphoid hyperplasia (ALH) RLH has to-
tally benign morphology and immunophenotype
whereas ALH has borderline lesions between
RLH and lymphoma [10] OAL and LH are
mostly seen in patients with age between 50-70
years old There are rare cases in pediatric group
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
114
[71011] In the C-Y Chengrsquos statistical report of
OAL in Taiwan only 8 patients were younger
than 15 years old among the 101 cases of ocular
lymphoma [2] According to an US study inci-
dence rates of OAL were analyzed in different
age groups the group of age over 50 had the
highest incidence rate of 574 per million per-
son-years while the 0-19 age group had the
lowest incidence rate of 009 per million per-
son-years [12] The incidence of LH was even
less than OAL [13]
Patients with OALD may be asymptomatic or
with symptoms of proptosis eyelid swelling a
palpable painless mass or conjunctival salmon
patch Diplopia visual loss pain or inflamma-
tion occurred less frequently implying more
aggressive features [714]
Orbital LH is not distinguishable from low-grade
lymphoma radiologically They both typically
present a round or lobulated mass that diffusely
moderately enhances with contrast and usually
shows homogenous hypointense or isointense to
muscle barely invasion to bone or nervous sys-
tem [10] Atypical appearances including inho-
mogeneous calcification or bony changes may
be seen in high-grade lymphoma case reports
such as ocular adnexal diffuse large B-cell lym-
phoma (DLBCL) which is one of the more ag-
gressive type of OAL [7] Whole body PET is
used for not only the evaluation of systemic
involvement but also the standard for staging
lymphoma Our patientrsquos image studies revealed
neither obvious local invasion nor systemic ma-
lignancy indicating high-grade lymphoma was
less likely Low-grade lymphoma and benign
reactive lymphoid hyperplasia were still under
consideration
Histomorphology analysis and immunohisto-
chemistry (IHC) are essential for diagnosis
Flow cytometry and polymerase chain reaction
(PCR) technique are also applied to help differ-
entiate from RLH and OAL [1016] Our case
had immunohistochemical profile of positivity
for CD20 predominantly positivity focally for
CD3 CD5 CD10 CD23 and negativity for cy-
clin-D1 BCL-6 staining was not performed in
our casersquos biopsy Thus according to the IHC
report RLH ALH and follicular lymphoma are
probable diagnosis of our patient
Radiation therapy is the standard treatment for
low-grade OAL that is classified as T1N0M0 or
T2N0M0 according to the AJCC criteria [15]
İncesoy-Ouml zdemir S et al reported a 10-year-old
boy diagnosed of MALT lymphoma who was
treated with local radiotherapy (36 Gy) and
there were no local or systemic recurrences dur-
ing his nearly four-year follow-up [17] Another
case report represented a 21-year-old man of
conjunctival follicular lymphoma treated with
surgical excision only showing no evidence of
recurrence after 8 months follow-up [18] Other
treatment options for pediatric and juvenile OAL
were performed in some case reports including
intravenous rituximab intralesional interfer-
on-α-2b topical interferon a6 systemic doxycy-
cline surgical excision and postoperative local
cryotherapy [15]
Treatment for young conjunctival RLH was less
discussed in the past In a case series article
three children (9 13 14 years old respectively)
of RLH received surgical resection without fur-
ther postoperative management and no signs of
recurrence were noted during follow-up [19]
Short-term topical and oral corticosteroids after
surgical excision were prescribed in two pediat-
ric RLH patients for their small residual mass
However poor response in both cases was nota-
ble [20]
Our patient declined to receive radiotherapy or
any further postoperative treatment mainly due
to his concerning of possible side effects (such
as dry eye and cataract)
CONCLUSION We present a rare case of caruncle mass in this
report OALD is one of the relatively uncommon
diagnosis among caruncular lesions OALD
includes benign RLH and malignant OAL
which are both mainly seen in elderly patients
even rarer in pediatric or juvenile group
The standard treatment for low-grade OAL and
RLH in young patents are still debatable How-
ever long-term follow-up is suggested for both
OAL and RLH patients Though RLH has a be-
nign and self-limited course risk of malignant
transformation is possible
REFERENCES 1 Levy J Ilsar M Deckel Y et al Lesions of
the caruncle a description of 42 cases and
a review of the literature Eye
200923(5)1004-1018
2 C-Y Cheng and W-M Hsu Incidence of
eye cancer in Taiwan an 18-year review
Eye 200418152-158
3 Chui-Lien Tsen Muh-Chiou Lin
Youn-Shen Bee et al Ocular adnexal
lymphoma Five case reports and a
literature review Taiwan Journal of
Ophthalmology 20155(2)99-102
4 Liesegang TJ Ocular adnexal
lymphoproliferative lesions Mayo Clin
Proc 199368(10)1003-1010
5 Kirkegaard MM Coupland SE Prause JU
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
115
et al Malignant lymphoma of the
conjunctiva Surv Ophthalmol
201560(5)444-458
6 Stacy RC Jakobiec FA Schoenfield L et
al Unifocal and multifocal reactive
lymphoid hyperplasia vs follicular
lymphoma of the ocular adnexa Am J
Ophthalmol 2010150(3)412-426
7 Sullivan TJ Ocular Adnexal
Lymphoproliferative Disease In Guthoff
RF Katowitz JA eds Oculoplastics and
Orbit Berlin Heidelberg Springer
20101-19
8 White Valerie A Understanding and
Classification of Ocular Lymphomas
Ocular Oncology and Pathology
20195379-386
9 Stefanovic A Lossos IS Extranodal
marginal zone lymphoma of the ocular
adnexa Blood 2009114(3)501-510
10 Andrew NH Coupland SE Pirbhai A et al
Lymphoid hyperplasia of the orbit and
ocular adnexa A clinical pathologic review
Surv Ophthalmol 201661(6)778-790
11 Ferry JA1 Fung CY Zukerberg L et al
Lymphoma of the ocular adnexa A study
of 353 cases Am J Surg Pathol
200731(2)170-184
12 WM Hassan MS Bakry HM Hassan et al
Incidence of orbital conjunctival and
lacrimal gland malignant tumors in USA
from Surveillance Epidemiology and End
Results 1973-2009 Int J Ophthalmol
20169(12)1808-1813
13 Ajay A Rao John H Naheedy James Y-Y
Chen et al A Clinical Update and
Radiologic Review of Pediatric Orbital
and Ocular Tumors Journal of Oncology
2013(9)975908
14 Sullivan TJ Whitehead K Williamson R
et al Lymphoproliferative disease of the
ocular adnexa a clinical and pathologic
study with statistical analysis of 69
patients Ophthal Plast Reconstr Surg
200521177-188
15 Tanenbaum RE Galor A Dubovy SR et al
Classification diagnosis and management
of conjunctival lymphoma Eye Vis (Lond)
2019622
16 Olga Klavdianou Georgios Kondylis
Vasileios Georgopoulos et al Bilateral
benign reactive lymphoid hyperplasia of
the conjunctiva a case treated with oral
doxycycline and review of the literature
Eye Vis (Lond) 2019626
17 İncesoy-Ouml zdemir S Yuumlksek N Bozkurt C
et al A rare type of cancer in children
extranodal marginal zone B-cell (MALT)
lymphoma of the ocular adnexa Turk J
Pediatr 201456(3)295-298
18 Lynn J Poole Perry Frederick A Jakobiec
Peter A D Rubin Conjunctival Pediatric
Follicular Lymphoma Arch Ophthalmol
2012130(7)941-943
19 Abdullah Al-Mujaini Upender Wali
Anuradha Ganesh1 et al Ocular Adnexal
Reactive Lymphoid Hyperplasia in
Children Middle East Afr J Ophthalmol
201219(4)406-409
20 McLeod SD Edward DP Benign
lymphoid hyperplasia of the conjunctiva in
children Arch Ophthalmol
1999117(6)832-835
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
116
FIGURES
Figure 1 Slit lamp image of a mass lesion at the patientrsquos left eye caruncle for one month
Figure 2 One month after the first excision a protruding mass recurred at the patientrsquos nasal canthus
of left eye It partially involved beyond the gray line of nasal part lower eyelid
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
117
Figure 3 Histomorphology analysis and immunohistochemistry study of the caruncular lesion Abun-
dant atypical lymphoid proliferation presented in low-power photomicrograph (A) and
high-power photomicrograph (B) under hematoxylin-eosin staining The lymphoid aggrega-
tion was composed predominantly of CD20-positive cells (C) and focal positive staining of
CD3 (D)
Figure 4 Non-contrast orbital computed tomography showed a lesion of soft tissue density at medial
canthus of left orbit without obvious nasolacrimal duct or bony invasion (A) Magnetic reso-
nance imaging with contrast showed strong enhancement at left medial canthus region (B)
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
118
Figure 5 The follow-up photo were taken at three months after the second excision showing no signs
of recurrence
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
119
Juvenile Caruncular Atypical Lymphoid Proliferation ndash A Rare Case Report
罕見病例報告mdash青少年之淚阜非典型淋巴增生
施驊瑋 1林友祺 1
中文摘要
淚阜病灶相當罕見大部分為良性病灶眼睛及附屬結構淋巴增生疾病為其
鑑別診斷之一非常少見於年輕人或兒童我們報告一位 16歲的健康男性因
左眼淚阜無痛性腫塊接受切除手術卻於術後一個月復發執行第二次切除手術
後門診追蹤十個月未再復發此案例表現了部分良性與部分惡性腫瘤的特徵
我們針對反應性淋巴增生眼睛及附屬結構淋巴癌兩個疾病做討論及文獻回顧
關鍵字淚阜病灶眼睛及附屬結構淋巴增生疾病眼睛及附屬結構淋巴癌反
應性淋巴增生非典型淋巴增生
1 新光吳火獅紀念醫院眼科
通訊作者林友祺 電子信箱 yuchi067gmailcom
Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh 120
Submitted March 26 2020
Final version accepted April 16
2020
Case Report
Hyperacute intramembranous hemor-
rhage after burr hole craniostomy for
chronic subdural hematoma
Cite as Meng-Chi Lin Jui-Ming
Sun Yu-Hao Chen Cheng-Ta
Hsieh
Hyperacute intramembranous
hemorrhage after burr hole crani-
ostomy for chronic subdural he-
matoma Fu-Jen Journal of Medi-
cine 3(4) 120-125 2020
DOI
103966181020932020091803004
Meng-Chi Lin1 Jui-Ming Sun23 Yu-Hao Chen24 Cheng-Ta
Hsieh567
1Department of Surgery Zuoying Branch Kaohsiung Armed Forces
General Hospital Kaohsiung 813 Taiwan 2Section of Neurosurgery Department of Surgery Chia-Yi Christian
Hospital Chia-Yi City 600 Taiwan 3Department of Biotechnology Asia University Taichung City 41354
Taiwan 4Chung-Jen Junior College of Nursing Health Sciences and Manage-
ment Chia-Yi Country 62241 Taiwan 5Division of Neurosurgery Department of Surgery Sijhih Cathay Gen-
eral Hospital New Taipei City 22174 Taiwan 6Department of Medicine School of Medicine Fu Jen Catholic Univer-
sity New Taipei City 24205 Taiwan 7Department of Neurological Surgery Tri-Service General Hospital
National Defense Medical Center Taipei 114 Taiwan
Corresponding author E-mail address
nogormail2000comtw (Cheng-Ta Hsieh)
ABSTRACT
Burr hole craniostomy with closed-system drainage is an effective and common neurosurgical procedure to manage chronic subdural hematoma Postoperative hem-orrhage a well-known but infrequent complication may result in increased neurolog-ical deficits However hyperacute intramembranous hemorrhage within the inner and outer membrane of hematoma after burr hole craniostomy with irrigation and closed-system drainage has not been described previously Herein we report a case of postoperative spontaneous hyperacute intramembranous hemorrhage after burr hole craniostomy with closed-system drainage to manage a chronic subdural hematoma we subsequently discuss the possible pathophysiological mechanisms and review the relevant literature
Keywords Chronic subdural hematoma acute subdural hematoma bleeding burr hole craniostomy
drainage
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Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh
125
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
慢性硬腦膜下出血進行鑽顱引流手術造成超急性夾膜內出
血
林孟楫 1孫瑞明 23陳昱豪 24謝政達 567
中文摘要
鑽顱併封閉系統引流手術是治療慢性硬腦膜下出血患者一種有效且常見的
神經外科手術方式術後出血可能導致神經功能缺損惡化是眾所周知但不常見
的併發症之一然而至今仍未有鑽孔併封閉系統引流造成原本慢性硬腦膜血
塊內膜和外膜間急性夾膜間出血案例在這裡我們報告一例慢性硬腦膜下出
血病患者接受鑽顱併封閉系統引流手術治療造成術後急性夾膜間出血我們在
本文中討論可能的致病機制並回顧相關文獻
關鍵字慢性硬腦膜下出血急性硬腦膜下出血出血鑽顱術引流
1國軍高雄總醫院左營分院 外科部
2崇仁醫護管理專科學校
3亞洲大學 生物科技學系
4戴德森醫療財團法人嘉義基督教醫院 外科部 神經外科
5汐止國泰綜合醫院 神經外科
6輔仁大學 醫學系
7 國防醫學院 三軍總醫院 神經外科
通訊作者謝政達 電子信箱 nogormail2000comtw
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
126
Submitted January 21 2020
Final version accepted July 08
2020
Case Report
Hamartoma of the breast A case report
Cite as Hsuan-An Chen
Cheng-Yu Lo Shih-Hung Huang
Chin-Lung Lin
Hamartoma of the breast A case
report Fu-Jen Journal of Medicine
3(5) 126-130 2020
DOI
103966181020932020091803005
Hsuan-An Chen1 Cheng-Yu Lo
3 Shih-Hung Huang
3 Chin-Lung
Lin2
1Department of Surgery Cathay General Hospital Taipei Taiwan
2Department of General Surgery Cathay General Hospital Taipei Tai-
wan
3Department of Pathology Cathay General Hospital Taipei Taiwan
Corresponding author E-mail address
lungyungmailcom (Chin-Lung Lin)
ABSTRACT
Breast hamartoma is an uncommon benign tumor rarely associated with malignancy An
excision and histological examination is necessary for the differential diagnosis We report
a case of a 49-year-old female patient presenting with a lump in the right breast Ultrasound
examination which demonstrated a 4411 cm hypoechoic lesion with lipoma Partial mas-
tectomy was arranged and the diagnosis of a hamartoma was confirmed by the histological
examination
Keywords Breast tumor Hamartoma Ultrasound
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
127
INTRODUCTION The hamartoma is a benign tumor-like lesion
that can affect various organs of the body in-
cluding lungs kidneys skin and more rarely the
breast In 1981 the hamartomas were recognized
in the WHO classification[1] They are defined
as well-demarcated mass of mammary ducts and
lobules containing varying amounts of fibrous
and adipose tissue and producing a distinctive
mammographic image
CASE REPORT A 49 year-old female had past history of left
breast mastitis with abscess status post partial
mastectomy This time she presented to our out
patient clinic for breast examination Physical
examination revealed a painless palpable mova-
ble and painless lump at upper outer quadrant of
right breast The risk of breast cancer was not
noted and the patient did not have any family
history of breast cancer The patient also denied
any trauma history before Ultrasound examina-
tion was arranged which demonstrated a 4411
cm hypoechoic lesion with lipoma at 3 oclock 2
cm from nipple of right breast and multiple hy-
poechoic nodules of various size in both breasts
and there was no suspicious axillary lymph
nodes noted (Figure1) Surgical treatment was
arranged partial mastectomy of right breast
harmartoma was successfully performed A 32 x
31 x 21 cm tumor was completely excised
Grossly examination showed a gray to yellow
and firm to fatty The diagnosis of a hamartoma
was confirmed by the histological examination
Microscopically sections of the breast lesion
show mammary hamartoma composed of ducts
lobules with interlobular fibrous tissue and adi-
pose tissue Fibrocystic change apocrine meta-
plastic ducts and scattered foci of adenosis are
noted The overall lobulocentric architecture and
the 2-cell pattern of the epithelium are preserved
columnar cell change and focal microcalcifica-
tion are present (Figure2) Based on submitted
biopsy specimen in-situ or invasive tumor cells
are not identified
DISCUSSION Hamartoma of the breast is a benign tumor like
nodule it was also known as fibroadenolipoma
lipofibroadenoma or adenolipoma based on its
predominant components It was composed of
varying amounts of glandular adipose and fi-
brous tissue[2] Hamartomas were first described
in 1971 by Arrigoni et al in a study of 10 patients
which breast tumors clinically and grossly re-
sembled fibroadenomas[3]
A higher predominance of tumors exists in fe-
males compared with males Hamartomas are
slowly-growing lesions with the diameter rang-
ing from 2 cm to 5 cm sometimes hamartomas
can reach giant diameter [4]
The clinical diagnosis of hamartoma is based on
the findings from mammography sonography
and histology examinations The hamartomas are
usually incidentally diagnosed by the women
older than 40 year-old starting mammography
screening
On physicial examination harmatomas are usu-
ally occult painless they may be as large mo-
bile soft to firm masses[5] Ultrasound showed
well capsulated mass with echogenic rim and
internal heterogeneity Mammography exam
showed well-circumscribed round to oval
masses containing fat and soft tissue densities
with a thin radiopaque pseudocapsule The
pseudocapsule results from displacement of
breast parenchyma by the tumor [56] In Pa-
thology finding microglandular adenosis is pre-
sent in fibroadipose stroma surrounded by a thin
fibrous capsule It composed of a combination of
epithelial and stromal elements usually with
normal ducts or lobules although variations of
normal tissue may also be seen Fibroadenoli-
poma myoid hamartoma and chondrolipoma are
histological variations of hamartomas depend-
ing on the proportion of normal breast tissue
elements[7]
Malignancy associated with hamartomas are
very rare[8] However it has been reported
hamartomas develop into carcinoma Malignant
transformation can occur as a result of cellular
atypia in the epithelial component of the mass[9]
Surgical removal is the curative method for
breast hamartomas[10] Diagnostic material such
as mammography ultrasonography or core nee-
dle biopsy may not give the definitive diagnosis
Therefore surgical excision and histological
examination is necessary for differential diagno-
sis[111213]
Although it is rare hamartoma can be seen along
with malignancy as it is formed from similar
components of breast tissue Therefore careful
diagnosis and appropriate management including
surgery are required
REFERENCES 1 World Health Organization (1981)
Histological typing of breast tumors In
International histological classification of
tumors 1981 2nd ed
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
128
2 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11435ndash449
2006
3 ArrigoniMG DockertyMB JuddES
The identificationand treatment of
mammary hamartoma Surg Gynecol
Obstet1971 133 577-82
4 Sanal HT Ersoz N Altinel O Unal E Can
C Giant hamartoma of the breast Breast J
2006 12 84-85
5 Feder JM de Paredes ES Hogge JP
Wilken JJ Unusual breast lesions
radiologic-pathologic correlation
Radiographics 1999 19S11ndashS26
6 Murat A Ozdemir H Yildirim H Poyraz
AK Ozercan R Hamartoma of the breast
Australas Radiol 200751 Spec NoB37ndash
9
7 Fisher CJ Hanby AM Robinson L Millis
RR Mammary hamartoma-a review of 35
cases Histopathology 1992 20 99-106
8 Choi N Ko ES Invasive ductal carcinoma
in a mammary hamartoma case report and
review of the literature Korean J Radiol
2010 Nov-Dec11(6)687-91
9 Lee EH Wylie EJ Bourke AG Bastiaan
De Boer W Invasive ductal carcinoma
arising in a breast hamartoma two case
reports and a review of the literature Clin
Radiol 2003 58 80-3
10 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11 435 ‑449
2006
11 Coyne J Hobbs FM Boggis C Harland R
Lobular carcinoma in a mammary
hamartoma J Clin Pathol 199245936ndash
937
12 G M K Tse B K B Law T K F Ma A B W
Chan Hamartoma of the breast a
clinicopathological review J Clin Pathol
200255951ndash954
13 RAAmir SSheikh BreasthamartomaA
report of 14cases of an under-recognized
and under-reported entity International
Journal of Surgery Case Reports
22(2016)1ndash4
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
129
FIGURES
Figure 1 Ultrasound shows a 4411 cm hypoechoic lesion with lipoma at 3 oclock 2 cm from nipple
of right breast
Figure 2 Photomicrograph shows mammary hamartoma composed of ducts lobules with interlobular
fibrous tissue and adipose tissue
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
130
Hamartoma of the breast A case report
乳房錯構瘤罕見個案報告
陳宣安 1羅承裕 3黃世鴻 3林錦龍 2
中文摘要
乳房錯構瘤是一種罕見之乳房良性腫瘤切除手術及病理化驗來做鑑別診斷
我們報告一位 49歲女性以可觸摸到無痛性右側乳房腫塊為臨床表徵超音波
看到一個邊緣清楚低迴音的腫塊病患接受手術切除病灶病理診斷證實為乳
房錯構瘤
關鍵字乳房腫瘤錯構瘤超音波攝影
1國泰綜合醫院外科部
2國泰綜合醫院一般外科
3國泰綜合醫院病理科
通訊作者林錦龍 電子信箱 lungyungmailcom
Fu-Jen Journal of Medicine
Mission and Goals
The Fu-Jen Journal of Medicine (FJJM) is a peer-reviewed journal which
aims to enhance research quality of staffs in the College of Medicine Fu Jen
Catholic University The journal publishes original investigations across a
wide range of medical disciplines including original research articles in basic
and clinical sciences case reports review articles brief reports and letter
to the editor FJJM is now issued by the Center of Medical Education in the
College of Medicine Fu Jen Catholic University To promote journal quality
the manuscript submitted to FJJM after August first 2015 has to be prepared
in English to meet the international standards
Issue Date
Publication Date
Institution
December 01 2003
September 30 2020
College of Medicine Fu Jen Catholic University
Honorable publisher Han-Sun Chiang
Publisher Ping-Keung Yip
Editor-in-chief Ming-Chieh Ma
Associate Editors Yu-Wen Lin
Editors
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Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang
99
Submitted October 11 2019
Final version accepted February
02 2020
Original Research Article
Human Factors Underlying Adverse
Medical Events Revisit Root Cause Anal-
ysis Cases Using the HFACS
Cite as Yu-Hsun Cheng
Sheng-Hui Hung Tung-Wen Ko
Pa-Chun Wang
Human Factors Underlying Ad-
verse Medical Events Revisit
Root Cause Analysis Cases Using
the HFACS Fu-Jen Journal of
Medicine 3(2) 99-111 2020
DOI
103966181020932020091803002
Yu-Hsun Cheng1 Sheng-Hui Hung
12 Tung-Wen Ko
3 Pa-Chun
Wang14
1Department of Quality Management Cathay General Hospital Taipei
Taiwan
2Institute of Health Policy and Management National Taiwan Universi-
ty Taipei Taiwan
3Center for Healthcare Quality Management Cheng Hsin General Hos-
pital Taipei Taiwan
4Fu Jen Catholic University School of Medicine New Taipei City Tai-
wan
Corresponding author E-mail address
drtonyseednettw (Pa-Chun Wang)
ABSTRACT Background Appropriate management of adverse medical events (AMEs) is the corner-
stone of patient safety Root cause analysis (RCA) is used to investigate serious or
high-frequency errors but is limited by its inability to explain a broader scope of factors
We re-reviewed RCA cases to understand the underlying human organizational or system-
ic factors affecting AMEs Methods A total of 40 consecutive RCA cases (2012-2016) were
retrieved from the AMEs database A panel was organized to retrospectively re-review these
cases using the Human Factor Analysis and Classification System HFACS Results For
active failures errors stemmed largely from performance-based (95) judgment and deci-
sion-making errors (875) Incorrectly followed procedures (816) and accidental
equipment operation (50) were the most common types of performance-based errors In-
adequate real-time assessment (686) and inappropriate operative actions (686) were
the most common decision-making errors For sources of latent failure teamwork problems
(275) including failure to effectively communicate (818) and communicate critical
information (727) were common Inadequate supervision (929) or command over-
sights (929) were the most common problems related to inadequate supervision (35)
Organizational programpolicy risks not adequately assessed (50) were the most common
problems related to policy and process problem (25) Conclusions The HFACS review
enhances our understanding of human factors underlying AMEs The HFACS reveals latent
supervisory organizational or systematic problems that cannot be addressed through tradi-
tional RCA Keywords patient safety adverse events root cause analysis human factors
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 100
INTRODUCTION Patient safety involves the reduction of patient
harm from potentially avoidable unintended
outcomes [1] Studies have revealed that 50ndash
80 of adverse medical events (AMEs) are pre-
ventable [2-4] to eliminate such errors the ap-
propriate management of AMEs hence repre-
sents the cornerstone of patient safety work
Through incident reporting investigation and
analysis healthcare providers can correct or
re-engineer their care processes to prevent inci-
dent recurrence [25] One of the most popular
tools for investigating AMEs is root cause anal-
ysis (RCA) RCA reconstructs a chain of errors
to identify the deviation of care from normal
processes Nonetheless with a lack of standard-
ized nomenclature and investigation procedures
RCA report conclusions are sometimes too sub-
jective and nonspecific to facilitate any actiona-
ble safety improvement plans [5-7] According
to the UK Health and Safety Executive defini-
tion human factors are environmental organiza-
tional occupational or individual human char-
acteristics which influence behavior at work
such that health and safety are affected [8] Hu-
mans and systems are prone to errors and stud-
ies have showed that nearly 70 of medical
errors involve human factors [2-4] Reasonrsquos
Swiss cheese model described the penetration of
causative human errors through layers of defen-
sive barriers leading to system collapse [9]
With much focus on the temporal sequence and
severity of departure from accepted practices in
an incident the effectiveness of RCA is often
challenged by its incapability of exploring un-
derlying human organization or even systemic
factors [5-7] Reason and others have proposed
that errors can occur at 4 levels 1) unsafe acts
(operator actions) 2) preconditions for unsafe
acts (environmental factors contributing to er-
rors) 3) inadequate supervision (management
actions affecting the operator) and 4) organiza-
tional influences (organizational culture policies
and procedures that affect the operator) [9]
Based on this theory Wiegmann and Shappell
developed the Human Factor Analysis Classifi-
cation System (HFACS) to describe human fac-
tors causing accidents from 4 tiers of categories
Each of these categories consists of nanocodes to
represent specific human behavior or system
problems leading to errors [9-10] The tier for
unsafe acts involves actual provider actions (er-
rors or rule violations) directly leading to events
The tier representing preconditions for unsafe
acts includes operational personnel and envi-
ronmental factors The supervision tier addresses
leadership problems operational planning fail-
ure or correction and supervisory ethics The
tier for organizational influences deals with re-
source management organizational climate and
operational processes (Supplement Table 1) The
HFACS provides standardized investigation
processes for the systematic analysis of common
causes of adverse events across national defense
nuclear power navy aviation and healthcare
industries Taiwan launched its nationwide
AME-reporting system the Taiwan Patient
Safety Reporting System (TPR) in 2004 RCA
methodology was subsequently introduced to the
healthcare industry by the Joint Commission of
Taiwan [11] Since 2012 appropriate manage-
ment of AMEs has been listed as a national pa-
tient safety goal [12] RCA is required by the
Ministry of Health and Welfare for major AMEs
Aside from RCA a comprehensive structural
reliable and valid framework is urgently re-
quired to further guide organizational or even
national patient safety policies In this study we
used the HFACS to review our RCA cases aim-
ing to investigate human factors underlying se-
vere or frequent AMEs
MATERIALS AND METHODS Through continuous sampling 40 consecutive
RCA cases (2012-2016) were retrieved from a
hospitalrsquos (Cathay General Hospital Taipei
Taiwan) AME-reporting system database The
database contains AMEs relating to areas such as
medication patient falls surgery transfusion
clinical care public accidents security hospital
violence tube-related complication unplanned
cardiopulmonary resuscitation laboratory testing
and examination and anesthesia The RCA cases
were sentinel or high-frequency events classified
according to severity assessment category (SAC)
[1113] The SAC is an evaluation method for
categorizing AMEs by severity of effect on pa-
tients health and risk of incident reoccurrence
The HFACS has been modified (from the US
Department of Defense version 70) and trans-
lated into Mandarin Chinese with authorization
from the original developers [10] The Chi-
nese-version HFACS for Taiwan is a valid in-
strument (content validity index 09 Cronbachrsquos
α gt07 interrater reliability Κ 04-10) equiva-
lent to the original English version [9] The
HFACS contains 4 tiers 13 subitems and 109
nanocodes (Supplement Table 1) A panel of 6
reviewers was established All reviewers were
from clinical or management (quality and patient
safety management) backgrounds Reviewers all
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 101
finished human factor education and were
trained to use the HFACS through a consensus
meeting Each RCA case was randomly assigned
to 2 reviewers Human factors leading to partic-
ular AMEs were identified and confirmed when
2 reviewers reached agreement The distribution
of errors among tiers subitems and nanocodes
are provided with descriptive statistics () The
study was approved by the Institutional Review
Board of Cathay General Hospital
(CGH-P105095)
RESULTS AMEs related to laboratory testing and examina-
tion (n = 16) clinical care (n = 9) and medica-
tion (n = 7) were the most commonly observed
in the RCA Most AMEs in this cohort are
ranked as being SAC level 3 (n = 15) or 4 (n =
17) (Table 1)
Acts (Active Failures)
This tier of errors contains 3 subitems and 13
nanocodes In the 40 RCA cases perfor-
mance-based errors for 38 (95) and judgment
and decision-making errors for 35 (875) com-
prised the most common error types with viola-
tion for 6 (15) less common Procedure fol-
lowed incorrectly for 31 out of 38 (816) was
the most common performance-based problem
Inadequate real-time risk management for 24 out
of 35 (686) was the most common judgment
or decision error All of the rule violations were
workaround types for 6 out of 6 (100) (Figure
1)
Preconditions(Latent Failures)
This tier of errors has 9 subitems and 58 nano-
codes In the 40 RCA cases teamwork for 11
(275) and environmental for 8 (20) factors
contributed to most of the errors with mental
and physical state the next most common factor
for 7 (175) Communication for 9 out of 11
(818) and information relay for 8 out of 11
(727) were the most common issues related to
teamwork Few contributors mentioned failures
related to technical errors for 4 (50) or physi-
cal for 1 (125) environment Not paying at-
tention for 4 out of 7 (571) and negative habit
transfer for 4 out of 7 (571) were common
mental contributes noted for 7 (100) Overcon-
fidence was the most common problem related
to emotional status for 4 out of 7 (571) Fa-
tigue was observed in only 2 cases for 2 out of 2
physical problems (100) (Figure 2)
Supervision(Direct Supervisory Chain of
Command)
This tier of errors contains 3 subitems and 17
nanocodes In the 40 RCA cases inadequate
supervision for 14 (35) and inappropriately
planned operations for 11 (275) factors con-
tributed to most of the respective errors fol-
lowed by supervisory violations for 7 (175)
Supervisory or command oversights for 13 out
of 14 (929) were the most common sources of
supervision inadequacy Authorized unnecessary
hazards for 7 out of 11 (636) were the most
common inappropriately planned operations
Failure to enforce rules for 6 out of 7 (857)
was the most common supervisory violation
(Figure 3)
Organization Influence (Upper-Level Man-
agement)
This tier of errors contains 4 subitems and 18
nanocodes In the 40 RCA cases policy and
process issues for 10 (25) and resources prob-
lem for 8 (20) were major concerns Few of
the respective problems are related to climate
and cultural influences for 2 (5) or to person-
nel selection and staffing for 1 (25) Poorly
assessed organizational programs or policy risks
for 5 out of 10 (50) were the most common
policy and process problems Failure to provide
adequate operational information resources for 4
out of 8 (50) and command and control re-
source deficiency for 3 out of 8 (375) were
the main resource management problems Little
was revealed regarding organizational climate
and culture (n = 1 out of 2 50) or staffing for 1
out of 1 (100) (Figure 4)
DISCUSSION Health care is a complex system comprising
many high-reliability organizations (HROs) The
vulnerability of HROs stems from the participa-
tion of multidisciplinary teams in the processes
along a variety of patient care timelines How-
ever humans and systems are inherently prone
to errors the appropriate management of AMEs
is acknowledged to be the cornerstone of patient
safety AMEs should be reported investigated
analyzed and handled appropriately[14] Theo-
retically by analyzing the pattern of key defects
providers can fix errors and re-engineer their
care processes to reduce the possibility of AME
recurrence Taiwan established its nationwide
TPR in 2004 so far 7000 health care facilities
have participated and the database has accumu-
lated more than 055 million AMEs[11] Infor-
mation generated from the TPR database can
improve patient safety at individual organiza-
tional or even national levels However despite
relentless efforts few substantial improvements
have been achieved in patient safety [15-17]
Since its introduction in Taiwan in 2006 the use
of RCA for AMEs has encountered some diffi-
culties 1) No structural and standardized
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 102
framework exists for investigation
cross-institution variability and interrater relia-
bility are often ignored 2) Conclusions are often
subjective and corrective recommendations are
less actionable relying on individual reviewersrsquo
professional backgrounds and their experiences
3) Much focus on event reconstruction and oper-
ator performance means that factors relating to
human behavior organizational culture and
system weakness are not comprehensively ad-
dressed [671718] Traditionally attempts to
improve patient safety in the health care industry
are largely reactive in nature identifying and
correcting errors in care processes [1920]
Causes of defects are not thoroughly understood
Proactive approaches must be taken to address
systematic problems within a complex system
[720] Research suggests that human error is a
causal factor in the occurrence of AMEs AME
investigation targets have moved from skill defi-
ciency toward decision-making attitudes super-
visory factors and even organizational climate
or culture HFACS methodology is based on the
Swiss cheese model that also emphasizes active
and latent failures [921] The study provides
some noteworthy findings First most AMEs as
expected involve active failures such as failure
to follow procedure accidental operation of
equipment inadequate real-time risk manage-
ment and inappropriate action These are all
sharp ends in classic RCA environment physi-
cal and mental factors are less prevalent This
proves that retrospectively determining addi-
tional causal factors is difficult when infor-
mation has not been collected during preliminary
investigation (Figure 1) Second team-
work-related problems particularly in relation to
communication and information relay are well
addressed This may be attributed to the dec-
ade-long institution-wide routine crew resource
management training in the respective research
hospital (Figure 2) Third the HFACS success-
fully reflects the importance of supervisory roles
in the occurrence of AMEs and this cannot be
overlooked (Figure 3) Fourth latent failures
especially in organizational climate or cultural
dimensions have been less frequently addressed
in incident reports a limitation of traditional
RCA However the HFACS review suggests
room for improvement in resource allocation and
policy modification within the hospital The
results of studies can make the organization
think about how to improve the patient safety
and management process from the perspective of
human factors such as improving the comfort of
the working environment and replacing and
equipment resources to prevent personnel from
affecting the medical quality and patient safety
due to the environment or equipment Need to
appropriate assessment of applicability and ade-
quate training of manpower is required The
management and control of risks should be fully
evaluate and grasp resource management and
leaders need to participate in and promote medi-
cal quality and patient safety activities to en-
hance its culture (Figure 4) No panacea exists
to ensure patient safety and improvement targets
originate largely from event investigation find-
ings Unfortunately factors identified from
AMEs are often self-explanatory with little value
for further action correction Reinforcement of
policy or processes redundant education or
repetitious training are formulaic overprescribed
RCA recommendations The use of HFACS in
this study proves that a structural prospective
AME investigation format can potentially help
with proactive patient safety management We
suggest developing an interview guideline for
the routine use of HFACS as a complement to
RCA in every AME investigation This study is a
retrospective study The underlying human fac-
tors can be under-estimated owing to the lack of
related information in the original RCA reports
CONCLUSION The HFACS review in this study enhances our
understanding of human factors in AMEs that
had previously been insufficiently scrutinized
Aside from active process and communication
errors the HFACS enables the prospective in-
vestigation of latent supervisory organizational
or systematic problems that cannot be addressed
through traditional RCA
REFERENCES 1 T Brennan L Leape N Laird et al
Incidence of adverse events and
negligence in hospitalized patients results
of the Harvard Medical Practice Study I N
Engl J Med 1991324370-376
2 Wang CH Shih CL Chen WJ et al
Epidemiology of medical adverse events
perspectives from a single institute in
Taiwan J Formos Med Assoc
2016115434-439
3 Vincent C Simon R Sutcliffe K et al
Errors Conference Executive Summary
Acad Emerg Med 200071180-1182
4 Taitz J Genn K Brooks V et al
System-wide learning from root cause
analysis A report from the New South
Wales Root Cause Analysis Review
Committee Qual Saf Health Care
2010191-5
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 103
5 Hutchinson A Young TA Cooper KL et
al Trends in healthcare incident reporting
and relationship to safety and quality data
in acute hospitals results from the
National Reporting and Learning System
Qual Saf Health Care 2009185-10
6 Mitchell RJ Williamson AM Molesworth
B et al A review of the use of human
factors classification frameworks that
identify causal factors for adverse events
in the hospital setting Ergonomics
2014571443-1472
7 Gurses AP Ozok AA Pronovost PJ Time
to accelerate integration of human factors
and ergonomics in patient safety BMJ
Qual Saf 201221347-351
8 Health and Safety Executive Introduction
to human factors
httpwwwhsegovukhumanfactorsintro
ductionhtm
9 Wiegmann DA Shappell SA A human
error approach to aviation accident
analysis The human factors analysis and
classification system Burlington VT
Ashgate Publishing Ltd 2003
10 Yu-Hsun Cheng Sheng-Hui Hung
Tung-Wen Ko et al An Analysis of the
Reliability and Validity of Human Factors
Analysis Classification System in Medical
Adverse Events Journal of Healthcare
Quality 20191370-76
11 Taiwan Joint Commission on Hospital
Accreditation Taiwan Patient-Safety
Reporting System Annual Report 2017
New Taipei City Taiwan
12 Taiwan Patient Safety Net
httpwwwpatientsafetymohwgovtwCo
ntentzMessagesslistaspxSiteID=1ampMm
mID=621273300317401756
13 Government of Western Australia
Department of Health
httpsww2healthwagovauArticlesS_T
Severity-assessment-codes
14 Farley DO Haviland A Champagne S et
al Adverse-event-reporting practices by
US hospitals results of a national survey
Qual Saf Health Care 200817416-423
15 Shojania KG Thomas EJ Trends in
adverse events over time why are we not
improving BMJ Qual Saf
201322273-277
16 Levitt P Challenging the systems approach
why adverse event rates are not improving
BMJ Qual Saf 2014231051-1052
17 Kellogg KM Hettinger Z Shah M et al
Our current approach to root cause
analysis is it contributing to our failure to
improve patient safety BMJ Qual Saf
201726381-387
18 Khorsandi M Skouras C Beatson K et al
Quality review of an adverse incident
reporting system and root cause analysis of
serious adverse surgical incidents in a
teaching hospital of Scotland Patient Saf
Surg 2012621
19 Diller T Helmrich G Dunning S et al
The Human Factors Analysis
Classification System (HFACS) Applied to
Health Care Am J Med Qual
201429181-190
20 Carayon P Xie A Kianfar S Human
factors and ergonomics as a patient safety
practice BMJ Qual Saf 201423196-205
21 Reason J Human Error New York
Cambridge University Press 1990
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 104
TABLE
Table 1 Incidences by Category (N=40)
CategorySAC SAC 4 SAC 3 SAC 2 SAC 1 total
Laboratory and ex-
amination events
4 10 2 0 16 (400)
Clinical care event 6 2 1 0 9 (225)
Medication event 5 0 2 0 7 (175)
Surgery-related event 1 1 2 0 4 (100)
Transfusion-related
event
1 1 0 0 2 (50)
Tube event 0 1 0 0 1 (25)
Public accident 0 0 1 0 1 (26)
Total 17 (425) 15 (375) 8 (200) 0 40 (100)
SAC 1113 Severity Assessment Code SAC
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 105
FIGURES
Figure 1 Active Failures (N=40)
16 (167)
66 (1000)
640 (150)
235 (57)
735 (200)
2435 (686)
2435 (686)
3540 (875)
438 (105)
438 (105)
738 (184)
1938 (500)
3138 (816)
3840 (950)
0 5 10 15 20 25 30 35 40
Commits WidespreadRoutine Violation
Performs Work-Around Violation
Ignored a CautionWarning
Failure to Prioritize Tasks Adequately
Wrong Choice of Action During an Operation
Inadequate Real‐Time Risk Assessment
Rushed or Delayed a Necessary Action
Breakdown in Visual Scan
Over-ControlledUnder-Controlled AircraftVehicleSystem
Unintended Operation of Equipment
Procedure Not Followed Correctly
Performance-Based Errors
Judgment and Decision Making Errors
Violations
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 106
Figure 2 Preconditions (Latent Failures or Conditions) (N=40)
14 (250)
24 (500)
48 (500)
11 (1000)
18 (125)
840 (200)
0 5 10 15 20 25 30 35 40
Seat and Restraint System Problems
Instrumentation amp Warning System Issues
Noise Interference
Environment
Physical Environment
Technological Environment
27 (286)
27 (286)
27 (286)
37 (129)
47 (511)
47 (571)
77 (1000)
24 (500)
44 (1000)
47 (571)
12 (500)
22 (1000)
27 (286)
740 (175)
0 5 10 15 20 25 30 35 40
Technical or Procedural Knowledge Not Retained After Training
InterferenceInterruption
Task OverUnder Saturation
Distraction
Negative Habit Transfer
Not Paying Attention
Complacency
Overconfidence
Physical IllnessInjury
Fatigue
Physical and Mental State
Physical Problem
State of Mind
Mental Awareness
211 (182)
311 (273)
311 (273)
411 (364)
811 (7227)
911 (818)
1140 (275)
0 5 10 15 20 25 30 35 40
Inadequate Task Delegation
TaskMission PlanningBriefingDebriefing Inadequate
Failure of CrewTeam Leadership
StandardProper Terminology Not Used
Critical Information Not Communicated
Failed to Effectively Communicate
Teamwork
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 107
Figure 3 Supervision (Direct Supervisory Chain of Command) (N=40)
Figure 4 Organization Influence (Upper-Level Management Command Level) (N=40)
114 (71)
114 (71)
214 (143)
314 (214)
1314 (929)
1440 (350)
511 (455)
511 (455)
711 (636)
1140 (275)
47 (571)
67 (857)
740 (175)
0 5 10 15 20 25 30 35 40
Selected Individual with Lack of Proficiency
Improper Role‐modeling
Failed to Provide Proper Training
Failed to IdentifyCorrect Risky or Unsafe Practices
SupervisoryCommand Oversight Inadequate
Performed Inadequate Risk Assessment ‐Formal
Selected Individual with Lack of Current or Limited Experience
Authorized Unnecessary Hazard
Allowing Unwritten Policies to Become Standard
Failure to Enforce Existing Rules
Supervisory Violations
Planned Inappropriate Operations
Inadequate Supervision
12 (500)
12 (500)
240 (50)
110 (100)
510 (500)
1040 (250)
11 (1000)
140 (25)
18 (125)
18 (125)
38 (35)
48 (500)
840 (200)
0 5 10 15 20 25 30 35 40
Organizational Over-confidence or Under-confidence in Equipment
Organizational Culture (attitude actions) Allows for Unsafe TaskMission
Purchasing or Providing Poorly Designed or Unsuitable Equipment
Organizational ProgramPolicy Risks not Adequately Assessed
Failure to Provide Adequate Manning Staffing Resources
Failure to remove inadequate worn-out equipment in timely manner
Inadequate infrastructure
Command and control resources are deficient
Failure to provide adequate operational information resources
Resource Problems
Personnel Selection amp Staffing
Policy and Process Issues
ClimateCulture Influences
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 108
Supplement Table 1- HFACS Content of Human Factor Analysis Classifi-
cation System [9] Tier main level sub-item nano code
Tier 1 Unsafe Acts
Perfor-
mance-Based
Errors
Unintended operation of equipment
Checklist not followed correctly
Procedure not followed correctly
Over-controlledunder-controlled aircraftvehiclesystem
Breakdown in visual scan
Rushed or delayed a necessary action
Judgment amp De-
cision-Making
Errors
Inadequate real‐time risk assessment
Failure to prioritize tasks adequately
Ignored a cautionwarning
Wrong choice of action during an operation
Violations
Performs work-around violation
Commits widespreadroutine violation
Extreme violation-lack of discipline
Tier 2 Preconditions
Environment
Physical environment
Environmental conditions affecting vision
Vibration effects vision or balance
Heatcold stress impairs performance
External force of object impeded an individualrsquos
movement
Lights of other vehiclevesselaircraft affected vision
Noise interference
Technological environment
Seat and restraint system problems
Instrumentation amp warning system issues
Visibility restrictions (not weather related)
Controls and switches are inadequate
Automated system creates unsafe situation
Workspace incompatible with operation
Personal equipment interference
Communication equipment inadequate
Physical and
Mental State
Physical problem
Substance effects (alcohol supplements medications
drugs)
Loss of consciousness (sudden or prolonged onset)
Physical illnessinjury
Fatigue
Inadequate adaptation to darkness
Dehydration
Body sizemovement limitations
Physical strength amp coordination (inappropriate for
task demands)
Nutritiondiet
State of mind
Psychological problem
Life stressors
Emotional state
Personality style
Overconfidence
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 109
Pressing
Complacency
Motivation
Motivational exhaustion (burnout)
Sensory misperception
Motion illusion-kinesthetic
Turning illusionbalance-vestibular
Visual illusion
Misperception of changing environment
Misinterpreted misread instrument
Misinterpretation of auditorysound cues
Spatial disorientation
Temporaltime distortion
Mental awareness
Not paying attention
Fixation
Task overunder saturation
Confusion
Negative habit transfer
Distraction
Geographically lost
Interferenceinterruption
Technical or procedural knowledge not retained after
training
Inaccurate expectation
Teamwork
Failure of crewteam leadership
Inadequate task delegation
Rankposition intimidation
Lack of assertiveness
Critical information not communicated
Standardproper terminology not used
Failed to effectively communicate
Taskmission planningbriefingdebriefing inadequate
Tier 3 Supervision
Supervisory Vio-
lations
Failure to enforce existing rules
Allowing unwritten policies to become standard
Directed individual to violate existing regulations
Authorized unqualified individuals for task
Planned Inappro-
priate Operations
Directed task beyond personnel capabilities
Inappropriate team composition
Selected individual with lack of current or limited experience
Performed inadequate risk assessment ‐formal
Authorized unnecessary hazard
Inadequate Su-
pervision
Supervisorycommand oversight inadequate
Improper role‐modeling
Failed to provide proper training
Failed to provide appropriate policyguidance
Personality conflict with supervisor
Lack of supervisory responses to critical information
Failed to identifycorrect risky or unsafe practices
Selected individual with lack of proficiency
Tier 4 Organizational
Influences
Resource Prob-
lems
Command and control resources are deficient
Inadequate infrastructure
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 110
Failure to remove inadequate worn-out equipment in timely
manner
Failure to provide adequate operational information resources
Fail to provide adequate funding
Personnel Selec-
tion amp Staffing
Personnel recruiting amp selection policies are inadequate
Failure to provide adequate manning staffing resources
Policy amp Process
Issues
Pace of ops-tempoworkload
Organizational programpolicy risks not adequately assessed
Provided inadequate procedural guidance or publications
Organizational (formal) training is inadequate or unavailable
Flawed doctrinephilosophy
Inadequate program management
Purchasing or providing poorly designed or unsuitable equip-
ment
ClimateCulture
Influences
Organizational culture (attitude actions) allows for unsafe
taskmission
Organizational over-confidence or under-confidence in equip-
ment
Unit missionaircraftvehicleequipment change or unit deacti-
vation
Organizational structure is unclear or inadequate
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 111
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
以 HFACS重新檢視根本原因分析案例挖掘造成醫療不良
事件之人為因素
鄭伃洵 1洪聖惠 12柯彤文 3王拔群 14
中文摘要
背景醫療不良事件(AMEs)的管理是促進病人安全的基石根本原因分析
(RCA)是探討重大病人安全不良事件問題但是由於無法解釋更廣泛的因素而受
到限制本研究使用人為因素分類與分析工具(HFACS)回溯審視醫療不良事件
以了解影響醫療不良事件的人為因素及各層面中錯誤原因之分佈或系統性問題
方法本研究回溯 2012-2016年間有做過根本原因分析之醫療不良事件以連續
性取樣方式(continuous sampling)收集 40例醫療不良事件以人為因素分類與分
析工具(HFACS)去系統性的挖掘每件案例發生錯誤之原因結果在行為層面中
分析結果主要為基礎技能錯誤(95)判斷和決策錯誤(875)其中在基礎技能
錯誤當中以未依程序作業執行(816)及未如預期設備操作(50)佔多數判斷和
決策錯誤中以現場風險評估不確實(686)及採取錯的步驟行為(686)佔多數
而在先決條件層面中以團隊合作(275)為主要因素包含溝通不良(818)及重
要訊息未以正確的方式即時傳達(727)佔多數在監督層面當中以監督不周
(929)或監督不妥當(929)為主要因素在組織政策和流程方面(50)以組織
系統的政策風險未充分評估(35)為主要因素結論本研究進一步了解醫療不
良事件在過去使用根本原因分析未探討到的人為因素反映出潛在的監督組織
行為或系統性的問題促進病人安全預防錯誤再發生
關鍵字病人安全醫療不良事件根本原因分析人為因素
1國泰醫療財團法人國泰綜合醫院 品質管理部
2國立臺灣大學健康政策與管理研究所
3振興醫療財團法人振興醫院 醫療品質管理中心
4輔仁大學醫學院
通訊作者王拔群 電子信箱 drtonyseednettw
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin 112
Submitted January 20 2020
Final version accepted April13
2020
Case Report
Juvenile Caruncular Atypical Lymphoid
Proliferation ndash A Rare Case Report
Cite as Hua-Wei Shih Yu-Chi Lin
Juvenile Caruncular Atypical
Lymphoid Proliferation ndash A Rare
Case Report Fu-Jen Journal of
Medicine 3(3) 112-119 2020
DOI
103966181020932020091803003
Hua-Wei Shih1 Yu-Chi Lin
1
1Department of Ophthalmology Shin Kong Wu Ho-Su Memorial Hos-
pital Taipei City Taiwan
Corresponding author E-mail address
yuchi067gmailcom (Yu-Chi Lin)
ABSTRACT
Lesions of the caruncle are very rare Most caruncular lesions are benign though there were still few reported malignant lesions Ocular adnexal lymphoproliferative disease (OALD) one of the differential diagnosis of caruncular lesion is seldom seen in young pa-tient In this article we report a 16-year-old boy with recurrent caruncular atypical lym-phoid proliferation We discuss the epidemiology clinical features images histomorpholo-gy and treatment between ocular adnexal lymphomas (OAL) and reactive lymphoid hyper-plasia (RLH)
Keywords caruncular lesion ocular adnexal lymphoproliferative disease ocular adnexal lymphoma
reactive lymphoid hyperplasia atypical lymphoid proliferation
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
113
INTRODUCTION Lesions of the caruncle are very rare Differen-
tial diagnosis includes nevus myeloproliferative
disorders tumors inflammation infection cysts
vascular lesions and fibrous Biopsy is essential
for diagnosis Levy J et al reported ocular ad-
nexal lymphoproliferative disease (OALD) was
relatively uncommon diagnosis among caruncu-
lar lesions [1]
OALD was seldom described in Asian popula-
tion especially for young age C-Y Cheng re-
ported age-standardized incidence of ocular
adnexal lymphomas (OAL) in Taiwan from 1979
to 1996 was below 07 per million per year and
mean age was 531 years old [2] In 2015 five
Taiwanese cases of OAL whose age ranging
from 45 to 64 were presented [3] However
there were few cases of conjunctival OAL or
RLH in Chinese pediatric patient
Here we present a case of 16-year-old boy with a
caruncular mass at his left eye with recurrence
one month after excision We describe his clini-
cal symptoms photographs pathological results
management and follow-up clinical course in
this report
CASE REPORT A 16-year-old healthy boy presented a mass
lesion at his left eye caruncle accompanied with
the symptom of tearing for one month (Figure 1)
He had no ocular pain no itchiness no blurred
vision no night sweating no fever and no body
weight loss The patient denied systemic diseas-
es and histories of surgery His bilateral best
corrected visual acuity (BCVA) were 66 and
intraocular pressure (IOP) were both within
normal range There were no remarkable find-
ings for his cornea lens fundus and physical
examination Excision was performed and the
mass was soft with fluid inside therefore con-
junctival pyogenic cyst was our initial diagnosis
However one month after the excision a pro-
truding mass recurred at the patientrsquos nasal can-
thus of left eye (Figure 2) There were some
differences compared to previous condition At
the first time the soft mass was contained in a
well-defined cyst wall which more favored py-
ogenic granulation However after short period
of recurrence solid consistency and unclear
margin were found which favored malignancy
Besides the mass partially involved beyond the
gray line of nasal part lower eyelid whereas last
time the cyst mainly extended from conjunctiva
of caruncle The second excisional biopsy was
performed Pathologic examination demonstrat-
ed abundant atypical lymphoid proliferation
(Figure 3A 3B) Immunohistochemical studies
showed that the lymphoid aggregation was
composed predominantly of CD20-positive cells
(Figure 3C) focal positive staining of CD3
(Figure 3D) CD5 CD23 CD10 and negative
staining of cyclin-D1 Unfortunately the cellular
morphology was difficult to be evaluated due to
marked crushing artifact Thus malignant lym-
phoma cannot be excluded totally
Orbital computed tomography (CT) showed a
lesion of soft tissue density at medial canthus of
left orbit without obvious nasolacrimal duct or
bony invasion (Figure 4A) Magnetic resonance
imaging (MRI) with contrast showed strong
enhancement at left medial canthus region (Fig-
ure 4B) There was no remarkable finding in the
systemic workup including complete blood
count and differential count biochemical pro-
files and 18F-fluoro-2-deoxyglucose positron
emission tomographycomputed tomography
(18F-FDG PETCT) indicating no evidence of
systemic involvement
After the second excision we preferred con-
servative management for him due to the uncer-
tainty of malignancy and to avoid side effects
from aggressive treatment No sign of recurrence
was noted after 10 months of observation The
follow-up photo was taken at three months after
the second operation (Figure 5)
DISCUSSION Ocular adnexal lymphoproliferative disease
(OALD) consists of the spectrum of lymphoid
disease affecting the tissues surrounding the eye
including ocular adnexal lymphomas (OAL) and
lymphoid hyperplasia (LH) [4] The conjunctiva
is an important location for extranodal lympho-
ma development which comprises 25 of OAL
[5]
OAL can be grouped into two categories based
on their appearance of cells under the micro-
scope low-grade and high-grade [6] Extranodal
marginal zone lymphoma of mucosa-associated
lymphoid tissue (EMZLMALT) is the most
common subtype of OAL followed by follicular
lymphoma [7-9] Both of the above are
low-grade lymphomas
LH can be further divided by histopathology into
reactive lymphoid hyperplasia (RLH) and atypi-
cal lymphoid hyperplasia (ALH) RLH has to-
tally benign morphology and immunophenotype
whereas ALH has borderline lesions between
RLH and lymphoma [10] OAL and LH are
mostly seen in patients with age between 50-70
years old There are rare cases in pediatric group
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
114
[71011] In the C-Y Chengrsquos statistical report of
OAL in Taiwan only 8 patients were younger
than 15 years old among the 101 cases of ocular
lymphoma [2] According to an US study inci-
dence rates of OAL were analyzed in different
age groups the group of age over 50 had the
highest incidence rate of 574 per million per-
son-years while the 0-19 age group had the
lowest incidence rate of 009 per million per-
son-years [12] The incidence of LH was even
less than OAL [13]
Patients with OALD may be asymptomatic or
with symptoms of proptosis eyelid swelling a
palpable painless mass or conjunctival salmon
patch Diplopia visual loss pain or inflamma-
tion occurred less frequently implying more
aggressive features [714]
Orbital LH is not distinguishable from low-grade
lymphoma radiologically They both typically
present a round or lobulated mass that diffusely
moderately enhances with contrast and usually
shows homogenous hypointense or isointense to
muscle barely invasion to bone or nervous sys-
tem [10] Atypical appearances including inho-
mogeneous calcification or bony changes may
be seen in high-grade lymphoma case reports
such as ocular adnexal diffuse large B-cell lym-
phoma (DLBCL) which is one of the more ag-
gressive type of OAL [7] Whole body PET is
used for not only the evaluation of systemic
involvement but also the standard for staging
lymphoma Our patientrsquos image studies revealed
neither obvious local invasion nor systemic ma-
lignancy indicating high-grade lymphoma was
less likely Low-grade lymphoma and benign
reactive lymphoid hyperplasia were still under
consideration
Histomorphology analysis and immunohisto-
chemistry (IHC) are essential for diagnosis
Flow cytometry and polymerase chain reaction
(PCR) technique are also applied to help differ-
entiate from RLH and OAL [1016] Our case
had immunohistochemical profile of positivity
for CD20 predominantly positivity focally for
CD3 CD5 CD10 CD23 and negativity for cy-
clin-D1 BCL-6 staining was not performed in
our casersquos biopsy Thus according to the IHC
report RLH ALH and follicular lymphoma are
probable diagnosis of our patient
Radiation therapy is the standard treatment for
low-grade OAL that is classified as T1N0M0 or
T2N0M0 according to the AJCC criteria [15]
İncesoy-Ouml zdemir S et al reported a 10-year-old
boy diagnosed of MALT lymphoma who was
treated with local radiotherapy (36 Gy) and
there were no local or systemic recurrences dur-
ing his nearly four-year follow-up [17] Another
case report represented a 21-year-old man of
conjunctival follicular lymphoma treated with
surgical excision only showing no evidence of
recurrence after 8 months follow-up [18] Other
treatment options for pediatric and juvenile OAL
were performed in some case reports including
intravenous rituximab intralesional interfer-
on-α-2b topical interferon a6 systemic doxycy-
cline surgical excision and postoperative local
cryotherapy [15]
Treatment for young conjunctival RLH was less
discussed in the past In a case series article
three children (9 13 14 years old respectively)
of RLH received surgical resection without fur-
ther postoperative management and no signs of
recurrence were noted during follow-up [19]
Short-term topical and oral corticosteroids after
surgical excision were prescribed in two pediat-
ric RLH patients for their small residual mass
However poor response in both cases was nota-
ble [20]
Our patient declined to receive radiotherapy or
any further postoperative treatment mainly due
to his concerning of possible side effects (such
as dry eye and cataract)
CONCLUSION We present a rare case of caruncle mass in this
report OALD is one of the relatively uncommon
diagnosis among caruncular lesions OALD
includes benign RLH and malignant OAL
which are both mainly seen in elderly patients
even rarer in pediatric or juvenile group
The standard treatment for low-grade OAL and
RLH in young patents are still debatable How-
ever long-term follow-up is suggested for both
OAL and RLH patients Though RLH has a be-
nign and self-limited course risk of malignant
transformation is possible
REFERENCES 1 Levy J Ilsar M Deckel Y et al Lesions of
the caruncle a description of 42 cases and
a review of the literature Eye
200923(5)1004-1018
2 C-Y Cheng and W-M Hsu Incidence of
eye cancer in Taiwan an 18-year review
Eye 200418152-158
3 Chui-Lien Tsen Muh-Chiou Lin
Youn-Shen Bee et al Ocular adnexal
lymphoma Five case reports and a
literature review Taiwan Journal of
Ophthalmology 20155(2)99-102
4 Liesegang TJ Ocular adnexal
lymphoproliferative lesions Mayo Clin
Proc 199368(10)1003-1010
5 Kirkegaard MM Coupland SE Prause JU
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
115
et al Malignant lymphoma of the
conjunctiva Surv Ophthalmol
201560(5)444-458
6 Stacy RC Jakobiec FA Schoenfield L et
al Unifocal and multifocal reactive
lymphoid hyperplasia vs follicular
lymphoma of the ocular adnexa Am J
Ophthalmol 2010150(3)412-426
7 Sullivan TJ Ocular Adnexal
Lymphoproliferative Disease In Guthoff
RF Katowitz JA eds Oculoplastics and
Orbit Berlin Heidelberg Springer
20101-19
8 White Valerie A Understanding and
Classification of Ocular Lymphomas
Ocular Oncology and Pathology
20195379-386
9 Stefanovic A Lossos IS Extranodal
marginal zone lymphoma of the ocular
adnexa Blood 2009114(3)501-510
10 Andrew NH Coupland SE Pirbhai A et al
Lymphoid hyperplasia of the orbit and
ocular adnexa A clinical pathologic review
Surv Ophthalmol 201661(6)778-790
11 Ferry JA1 Fung CY Zukerberg L et al
Lymphoma of the ocular adnexa A study
of 353 cases Am J Surg Pathol
200731(2)170-184
12 WM Hassan MS Bakry HM Hassan et al
Incidence of orbital conjunctival and
lacrimal gland malignant tumors in USA
from Surveillance Epidemiology and End
Results 1973-2009 Int J Ophthalmol
20169(12)1808-1813
13 Ajay A Rao John H Naheedy James Y-Y
Chen et al A Clinical Update and
Radiologic Review of Pediatric Orbital
and Ocular Tumors Journal of Oncology
2013(9)975908
14 Sullivan TJ Whitehead K Williamson R
et al Lymphoproliferative disease of the
ocular adnexa a clinical and pathologic
study with statistical analysis of 69
patients Ophthal Plast Reconstr Surg
200521177-188
15 Tanenbaum RE Galor A Dubovy SR et al
Classification diagnosis and management
of conjunctival lymphoma Eye Vis (Lond)
2019622
16 Olga Klavdianou Georgios Kondylis
Vasileios Georgopoulos et al Bilateral
benign reactive lymphoid hyperplasia of
the conjunctiva a case treated with oral
doxycycline and review of the literature
Eye Vis (Lond) 2019626
17 İncesoy-Ouml zdemir S Yuumlksek N Bozkurt C
et al A rare type of cancer in children
extranodal marginal zone B-cell (MALT)
lymphoma of the ocular adnexa Turk J
Pediatr 201456(3)295-298
18 Lynn J Poole Perry Frederick A Jakobiec
Peter A D Rubin Conjunctival Pediatric
Follicular Lymphoma Arch Ophthalmol
2012130(7)941-943
19 Abdullah Al-Mujaini Upender Wali
Anuradha Ganesh1 et al Ocular Adnexal
Reactive Lymphoid Hyperplasia in
Children Middle East Afr J Ophthalmol
201219(4)406-409
20 McLeod SD Edward DP Benign
lymphoid hyperplasia of the conjunctiva in
children Arch Ophthalmol
1999117(6)832-835
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
116
FIGURES
Figure 1 Slit lamp image of a mass lesion at the patientrsquos left eye caruncle for one month
Figure 2 One month after the first excision a protruding mass recurred at the patientrsquos nasal canthus
of left eye It partially involved beyond the gray line of nasal part lower eyelid
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
117
Figure 3 Histomorphology analysis and immunohistochemistry study of the caruncular lesion Abun-
dant atypical lymphoid proliferation presented in low-power photomicrograph (A) and
high-power photomicrograph (B) under hematoxylin-eosin staining The lymphoid aggrega-
tion was composed predominantly of CD20-positive cells (C) and focal positive staining of
CD3 (D)
Figure 4 Non-contrast orbital computed tomography showed a lesion of soft tissue density at medial
canthus of left orbit without obvious nasolacrimal duct or bony invasion (A) Magnetic reso-
nance imaging with contrast showed strong enhancement at left medial canthus region (B)
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
118
Figure 5 The follow-up photo were taken at three months after the second excision showing no signs
of recurrence
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
119
Juvenile Caruncular Atypical Lymphoid Proliferation ndash A Rare Case Report
罕見病例報告mdash青少年之淚阜非典型淋巴增生
施驊瑋 1林友祺 1
中文摘要
淚阜病灶相當罕見大部分為良性病灶眼睛及附屬結構淋巴增生疾病為其
鑑別診斷之一非常少見於年輕人或兒童我們報告一位 16歲的健康男性因
左眼淚阜無痛性腫塊接受切除手術卻於術後一個月復發執行第二次切除手術
後門診追蹤十個月未再復發此案例表現了部分良性與部分惡性腫瘤的特徵
我們針對反應性淋巴增生眼睛及附屬結構淋巴癌兩個疾病做討論及文獻回顧
關鍵字淚阜病灶眼睛及附屬結構淋巴增生疾病眼睛及附屬結構淋巴癌反
應性淋巴增生非典型淋巴增生
1 新光吳火獅紀念醫院眼科
通訊作者林友祺 電子信箱 yuchi067gmailcom
Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh 120
Submitted March 26 2020
Final version accepted April 16
2020
Case Report
Hyperacute intramembranous hemor-
rhage after burr hole craniostomy for
chronic subdural hematoma
Cite as Meng-Chi Lin Jui-Ming
Sun Yu-Hao Chen Cheng-Ta
Hsieh
Hyperacute intramembranous
hemorrhage after burr hole crani-
ostomy for chronic subdural he-
matoma Fu-Jen Journal of Medi-
cine 3(4) 120-125 2020
DOI
103966181020932020091803004
Meng-Chi Lin1 Jui-Ming Sun23 Yu-Hao Chen24 Cheng-Ta
Hsieh567
1Department of Surgery Zuoying Branch Kaohsiung Armed Forces
General Hospital Kaohsiung 813 Taiwan 2Section of Neurosurgery Department of Surgery Chia-Yi Christian
Hospital Chia-Yi City 600 Taiwan 3Department of Biotechnology Asia University Taichung City 41354
Taiwan 4Chung-Jen Junior College of Nursing Health Sciences and Manage-
ment Chia-Yi Country 62241 Taiwan 5Division of Neurosurgery Department of Surgery Sijhih Cathay Gen-
eral Hospital New Taipei City 22174 Taiwan 6Department of Medicine School of Medicine Fu Jen Catholic Univer-
sity New Taipei City 24205 Taiwan 7Department of Neurological Surgery Tri-Service General Hospital
National Defense Medical Center Taipei 114 Taiwan
Corresponding author E-mail address
nogormail2000comtw (Cheng-Ta Hsieh)
ABSTRACT
Burr hole craniostomy with closed-system drainage is an effective and common neurosurgical procedure to manage chronic subdural hematoma Postoperative hem-orrhage a well-known but infrequent complication may result in increased neurolog-ical deficits However hyperacute intramembranous hemorrhage within the inner and outer membrane of hematoma after burr hole craniostomy with irrigation and closed-system drainage has not been described previously Herein we report a case of postoperative spontaneous hyperacute intramembranous hemorrhage after burr hole craniostomy with closed-system drainage to manage a chronic subdural hematoma we subsequently discuss the possible pathophysiological mechanisms and review the relevant literature
Keywords Chronic subdural hematoma acute subdural hematoma bleeding burr hole craniostomy
drainage
Fu-J
Meng
INTChromostcal inof usubdmemthat draintechnvidehemowellacutecrani[7 8withacutehole pathorelev
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Jen Journal o
g-Chi Lin Ju
TRODUConic subdural t common contervention [1
unabsorbed andural space mbranes [4] A
burr hole cnage systems nique for CSs a favorableorrhagic com-documented e intramembriostomy for C8] Herein w
h CSDH who e intramembr
craniostomyophysiologicavant literature
ASE REPO1-year-old wo
without regubeen taking
ing Ganoderms She was rment when shrological exasgow Coma Scmuscle strengt
was 45 on e Her labora
h the normal ranoted Brain
n revealed CSh a marked mntly she receiviostomy withnage ing surgery mhe subdural sp
of the duralatoma The arle saline throued drainage sy
wever this incm the subdural
aled a hyperadural space friostomy site iotomy with the hematomaorrhage was oinner memb
of Medicine V
i-Ming Sun Y
CTION hematoma (C
onditions requ1-3] is a prognd liquefied hbetween the
Accumulating craniostomy is an effectivDH treatmen
e outcome [5]mplications for
[4 6 7] Horanous bleedinCSDH has rarewe report the
developed spranous hemory Subsequenal mechanismis reviewed
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Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh
125
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
慢性硬腦膜下出血進行鑽顱引流手術造成超急性夾膜內出
血
林孟楫 1孫瑞明 23陳昱豪 24謝政達 567
中文摘要
鑽顱併封閉系統引流手術是治療慢性硬腦膜下出血患者一種有效且常見的
神經外科手術方式術後出血可能導致神經功能缺損惡化是眾所周知但不常見
的併發症之一然而至今仍未有鑽孔併封閉系統引流造成原本慢性硬腦膜血
塊內膜和外膜間急性夾膜間出血案例在這裡我們報告一例慢性硬腦膜下出
血病患者接受鑽顱併封閉系統引流手術治療造成術後急性夾膜間出血我們在
本文中討論可能的致病機制並回顧相關文獻
關鍵字慢性硬腦膜下出血急性硬腦膜下出血出血鑽顱術引流
1國軍高雄總醫院左營分院 外科部
2崇仁醫護管理專科學校
3亞洲大學 生物科技學系
4戴德森醫療財團法人嘉義基督教醫院 外科部 神經外科
5汐止國泰綜合醫院 神經外科
6輔仁大學 醫學系
7 國防醫學院 三軍總醫院 神經外科
通訊作者謝政達 電子信箱 nogormail2000comtw
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
126
Submitted January 21 2020
Final version accepted July 08
2020
Case Report
Hamartoma of the breast A case report
Cite as Hsuan-An Chen
Cheng-Yu Lo Shih-Hung Huang
Chin-Lung Lin
Hamartoma of the breast A case
report Fu-Jen Journal of Medicine
3(5) 126-130 2020
DOI
103966181020932020091803005
Hsuan-An Chen1 Cheng-Yu Lo
3 Shih-Hung Huang
3 Chin-Lung
Lin2
1Department of Surgery Cathay General Hospital Taipei Taiwan
2Department of General Surgery Cathay General Hospital Taipei Tai-
wan
3Department of Pathology Cathay General Hospital Taipei Taiwan
Corresponding author E-mail address
lungyungmailcom (Chin-Lung Lin)
ABSTRACT
Breast hamartoma is an uncommon benign tumor rarely associated with malignancy An
excision and histological examination is necessary for the differential diagnosis We report
a case of a 49-year-old female patient presenting with a lump in the right breast Ultrasound
examination which demonstrated a 4411 cm hypoechoic lesion with lipoma Partial mas-
tectomy was arranged and the diagnosis of a hamartoma was confirmed by the histological
examination
Keywords Breast tumor Hamartoma Ultrasound
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
127
INTRODUCTION The hamartoma is a benign tumor-like lesion
that can affect various organs of the body in-
cluding lungs kidneys skin and more rarely the
breast In 1981 the hamartomas were recognized
in the WHO classification[1] They are defined
as well-demarcated mass of mammary ducts and
lobules containing varying amounts of fibrous
and adipose tissue and producing a distinctive
mammographic image
CASE REPORT A 49 year-old female had past history of left
breast mastitis with abscess status post partial
mastectomy This time she presented to our out
patient clinic for breast examination Physical
examination revealed a painless palpable mova-
ble and painless lump at upper outer quadrant of
right breast The risk of breast cancer was not
noted and the patient did not have any family
history of breast cancer The patient also denied
any trauma history before Ultrasound examina-
tion was arranged which demonstrated a 4411
cm hypoechoic lesion with lipoma at 3 oclock 2
cm from nipple of right breast and multiple hy-
poechoic nodules of various size in both breasts
and there was no suspicious axillary lymph
nodes noted (Figure1) Surgical treatment was
arranged partial mastectomy of right breast
harmartoma was successfully performed A 32 x
31 x 21 cm tumor was completely excised
Grossly examination showed a gray to yellow
and firm to fatty The diagnosis of a hamartoma
was confirmed by the histological examination
Microscopically sections of the breast lesion
show mammary hamartoma composed of ducts
lobules with interlobular fibrous tissue and adi-
pose tissue Fibrocystic change apocrine meta-
plastic ducts and scattered foci of adenosis are
noted The overall lobulocentric architecture and
the 2-cell pattern of the epithelium are preserved
columnar cell change and focal microcalcifica-
tion are present (Figure2) Based on submitted
biopsy specimen in-situ or invasive tumor cells
are not identified
DISCUSSION Hamartoma of the breast is a benign tumor like
nodule it was also known as fibroadenolipoma
lipofibroadenoma or adenolipoma based on its
predominant components It was composed of
varying amounts of glandular adipose and fi-
brous tissue[2] Hamartomas were first described
in 1971 by Arrigoni et al in a study of 10 patients
which breast tumors clinically and grossly re-
sembled fibroadenomas[3]
A higher predominance of tumors exists in fe-
males compared with males Hamartomas are
slowly-growing lesions with the diameter rang-
ing from 2 cm to 5 cm sometimes hamartomas
can reach giant diameter [4]
The clinical diagnosis of hamartoma is based on
the findings from mammography sonography
and histology examinations The hamartomas are
usually incidentally diagnosed by the women
older than 40 year-old starting mammography
screening
On physicial examination harmatomas are usu-
ally occult painless they may be as large mo-
bile soft to firm masses[5] Ultrasound showed
well capsulated mass with echogenic rim and
internal heterogeneity Mammography exam
showed well-circumscribed round to oval
masses containing fat and soft tissue densities
with a thin radiopaque pseudocapsule The
pseudocapsule results from displacement of
breast parenchyma by the tumor [56] In Pa-
thology finding microglandular adenosis is pre-
sent in fibroadipose stroma surrounded by a thin
fibrous capsule It composed of a combination of
epithelial and stromal elements usually with
normal ducts or lobules although variations of
normal tissue may also be seen Fibroadenoli-
poma myoid hamartoma and chondrolipoma are
histological variations of hamartomas depend-
ing on the proportion of normal breast tissue
elements[7]
Malignancy associated with hamartomas are
very rare[8] However it has been reported
hamartomas develop into carcinoma Malignant
transformation can occur as a result of cellular
atypia in the epithelial component of the mass[9]
Surgical removal is the curative method for
breast hamartomas[10] Diagnostic material such
as mammography ultrasonography or core nee-
dle biopsy may not give the definitive diagnosis
Therefore surgical excision and histological
examination is necessary for differential diagno-
sis[111213]
Although it is rare hamartoma can be seen along
with malignancy as it is formed from similar
components of breast tissue Therefore careful
diagnosis and appropriate management including
surgery are required
REFERENCES 1 World Health Organization (1981)
Histological typing of breast tumors In
International histological classification of
tumors 1981 2nd ed
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
128
2 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11435ndash449
2006
3 ArrigoniMG DockertyMB JuddES
The identificationand treatment of
mammary hamartoma Surg Gynecol
Obstet1971 133 577-82
4 Sanal HT Ersoz N Altinel O Unal E Can
C Giant hamartoma of the breast Breast J
2006 12 84-85
5 Feder JM de Paredes ES Hogge JP
Wilken JJ Unusual breast lesions
radiologic-pathologic correlation
Radiographics 1999 19S11ndashS26
6 Murat A Ozdemir H Yildirim H Poyraz
AK Ozercan R Hamartoma of the breast
Australas Radiol 200751 Spec NoB37ndash
9
7 Fisher CJ Hanby AM Robinson L Millis
RR Mammary hamartoma-a review of 35
cases Histopathology 1992 20 99-106
8 Choi N Ko ES Invasive ductal carcinoma
in a mammary hamartoma case report and
review of the literature Korean J Radiol
2010 Nov-Dec11(6)687-91
9 Lee EH Wylie EJ Bourke AG Bastiaan
De Boer W Invasive ductal carcinoma
arising in a breast hamartoma two case
reports and a review of the literature Clin
Radiol 2003 58 80-3
10 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11 435 ‑449
2006
11 Coyne J Hobbs FM Boggis C Harland R
Lobular carcinoma in a mammary
hamartoma J Clin Pathol 199245936ndash
937
12 G M K Tse B K B Law T K F Ma A B W
Chan Hamartoma of the breast a
clinicopathological review J Clin Pathol
200255951ndash954
13 RAAmir SSheikh BreasthamartomaA
report of 14cases of an under-recognized
and under-reported entity International
Journal of Surgery Case Reports
22(2016)1ndash4
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
129
FIGURES
Figure 1 Ultrasound shows a 4411 cm hypoechoic lesion with lipoma at 3 oclock 2 cm from nipple
of right breast
Figure 2 Photomicrograph shows mammary hamartoma composed of ducts lobules with interlobular
fibrous tissue and adipose tissue
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
130
Hamartoma of the breast A case report
乳房錯構瘤罕見個案報告
陳宣安 1羅承裕 3黃世鴻 3林錦龍 2
中文摘要
乳房錯構瘤是一種罕見之乳房良性腫瘤切除手術及病理化驗來做鑑別診斷
我們報告一位 49歲女性以可觸摸到無痛性右側乳房腫塊為臨床表徵超音波
看到一個邊緣清楚低迴音的腫塊病患接受手術切除病灶病理診斷證實為乳
房錯構瘤
關鍵字乳房腫瘤錯構瘤超音波攝影
1國泰綜合醫院外科部
2國泰綜合醫院一般外科
3國泰綜合醫院病理科
通訊作者林錦龍 電子信箱 lungyungmailcom
Fu-Jen Journal of Medicine
Mission and Goals
The Fu-Jen Journal of Medicine (FJJM) is a peer-reviewed journal which
aims to enhance research quality of staffs in the College of Medicine Fu Jen
Catholic University The journal publishes original investigations across a
wide range of medical disciplines including original research articles in basic
and clinical sciences case reports review articles brief reports and letter
to the editor FJJM is now issued by the Center of Medical Education in the
College of Medicine Fu Jen Catholic University To promote journal quality
the manuscript submitted to FJJM after August first 2015 has to be prepared
in English to meet the international standards
Issue Date
Publication Date
Institution
December 01 2003
September 30 2020
College of Medicine Fu Jen Catholic University
Honorable publisher Han-Sun Chiang
Publisher Ping-Keung Yip
Editor-in-chief Ming-Chieh Ma
Associate Editors Yu-Wen Lin
Editors
Telephone (02) 2905-3477
Address Center for Medical Education College of Medicine Fu Jen
Catholic University
No 510 Zhongzheng Rd Xinzhuang Dist New Taipei City
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Su-Jane Wang Chi-Chung Wang Chih-Ming Ho
Yih-Jing Lee Chih-Shung Wong Tze-Wah Kao
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Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang
99
Submitted October 11 2019
Final version accepted February
02 2020
Original Research Article
Human Factors Underlying Adverse
Medical Events Revisit Root Cause Anal-
ysis Cases Using the HFACS
Cite as Yu-Hsun Cheng
Sheng-Hui Hung Tung-Wen Ko
Pa-Chun Wang
Human Factors Underlying Ad-
verse Medical Events Revisit
Root Cause Analysis Cases Using
the HFACS Fu-Jen Journal of
Medicine 3(2) 99-111 2020
DOI
103966181020932020091803002
Yu-Hsun Cheng1 Sheng-Hui Hung
12 Tung-Wen Ko
3 Pa-Chun
Wang14
1Department of Quality Management Cathay General Hospital Taipei
Taiwan
2Institute of Health Policy and Management National Taiwan Universi-
ty Taipei Taiwan
3Center for Healthcare Quality Management Cheng Hsin General Hos-
pital Taipei Taiwan
4Fu Jen Catholic University School of Medicine New Taipei City Tai-
wan
Corresponding author E-mail address
drtonyseednettw (Pa-Chun Wang)
ABSTRACT Background Appropriate management of adverse medical events (AMEs) is the corner-
stone of patient safety Root cause analysis (RCA) is used to investigate serious or
high-frequency errors but is limited by its inability to explain a broader scope of factors
We re-reviewed RCA cases to understand the underlying human organizational or system-
ic factors affecting AMEs Methods A total of 40 consecutive RCA cases (2012-2016) were
retrieved from the AMEs database A panel was organized to retrospectively re-review these
cases using the Human Factor Analysis and Classification System HFACS Results For
active failures errors stemmed largely from performance-based (95) judgment and deci-
sion-making errors (875) Incorrectly followed procedures (816) and accidental
equipment operation (50) were the most common types of performance-based errors In-
adequate real-time assessment (686) and inappropriate operative actions (686) were
the most common decision-making errors For sources of latent failure teamwork problems
(275) including failure to effectively communicate (818) and communicate critical
information (727) were common Inadequate supervision (929) or command over-
sights (929) were the most common problems related to inadequate supervision (35)
Organizational programpolicy risks not adequately assessed (50) were the most common
problems related to policy and process problem (25) Conclusions The HFACS review
enhances our understanding of human factors underlying AMEs The HFACS reveals latent
supervisory organizational or systematic problems that cannot be addressed through tradi-
tional RCA Keywords patient safety adverse events root cause analysis human factors
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 100
INTRODUCTION Patient safety involves the reduction of patient
harm from potentially avoidable unintended
outcomes [1] Studies have revealed that 50ndash
80 of adverse medical events (AMEs) are pre-
ventable [2-4] to eliminate such errors the ap-
propriate management of AMEs hence repre-
sents the cornerstone of patient safety work
Through incident reporting investigation and
analysis healthcare providers can correct or
re-engineer their care processes to prevent inci-
dent recurrence [25] One of the most popular
tools for investigating AMEs is root cause anal-
ysis (RCA) RCA reconstructs a chain of errors
to identify the deviation of care from normal
processes Nonetheless with a lack of standard-
ized nomenclature and investigation procedures
RCA report conclusions are sometimes too sub-
jective and nonspecific to facilitate any actiona-
ble safety improvement plans [5-7] According
to the UK Health and Safety Executive defini-
tion human factors are environmental organiza-
tional occupational or individual human char-
acteristics which influence behavior at work
such that health and safety are affected [8] Hu-
mans and systems are prone to errors and stud-
ies have showed that nearly 70 of medical
errors involve human factors [2-4] Reasonrsquos
Swiss cheese model described the penetration of
causative human errors through layers of defen-
sive barriers leading to system collapse [9]
With much focus on the temporal sequence and
severity of departure from accepted practices in
an incident the effectiveness of RCA is often
challenged by its incapability of exploring un-
derlying human organization or even systemic
factors [5-7] Reason and others have proposed
that errors can occur at 4 levels 1) unsafe acts
(operator actions) 2) preconditions for unsafe
acts (environmental factors contributing to er-
rors) 3) inadequate supervision (management
actions affecting the operator) and 4) organiza-
tional influences (organizational culture policies
and procedures that affect the operator) [9]
Based on this theory Wiegmann and Shappell
developed the Human Factor Analysis Classifi-
cation System (HFACS) to describe human fac-
tors causing accidents from 4 tiers of categories
Each of these categories consists of nanocodes to
represent specific human behavior or system
problems leading to errors [9-10] The tier for
unsafe acts involves actual provider actions (er-
rors or rule violations) directly leading to events
The tier representing preconditions for unsafe
acts includes operational personnel and envi-
ronmental factors The supervision tier addresses
leadership problems operational planning fail-
ure or correction and supervisory ethics The
tier for organizational influences deals with re-
source management organizational climate and
operational processes (Supplement Table 1) The
HFACS provides standardized investigation
processes for the systematic analysis of common
causes of adverse events across national defense
nuclear power navy aviation and healthcare
industries Taiwan launched its nationwide
AME-reporting system the Taiwan Patient
Safety Reporting System (TPR) in 2004 RCA
methodology was subsequently introduced to the
healthcare industry by the Joint Commission of
Taiwan [11] Since 2012 appropriate manage-
ment of AMEs has been listed as a national pa-
tient safety goal [12] RCA is required by the
Ministry of Health and Welfare for major AMEs
Aside from RCA a comprehensive structural
reliable and valid framework is urgently re-
quired to further guide organizational or even
national patient safety policies In this study we
used the HFACS to review our RCA cases aim-
ing to investigate human factors underlying se-
vere or frequent AMEs
MATERIALS AND METHODS Through continuous sampling 40 consecutive
RCA cases (2012-2016) were retrieved from a
hospitalrsquos (Cathay General Hospital Taipei
Taiwan) AME-reporting system database The
database contains AMEs relating to areas such as
medication patient falls surgery transfusion
clinical care public accidents security hospital
violence tube-related complication unplanned
cardiopulmonary resuscitation laboratory testing
and examination and anesthesia The RCA cases
were sentinel or high-frequency events classified
according to severity assessment category (SAC)
[1113] The SAC is an evaluation method for
categorizing AMEs by severity of effect on pa-
tients health and risk of incident reoccurrence
The HFACS has been modified (from the US
Department of Defense version 70) and trans-
lated into Mandarin Chinese with authorization
from the original developers [10] The Chi-
nese-version HFACS for Taiwan is a valid in-
strument (content validity index 09 Cronbachrsquos
α gt07 interrater reliability Κ 04-10) equiva-
lent to the original English version [9] The
HFACS contains 4 tiers 13 subitems and 109
nanocodes (Supplement Table 1) A panel of 6
reviewers was established All reviewers were
from clinical or management (quality and patient
safety management) backgrounds Reviewers all
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 101
finished human factor education and were
trained to use the HFACS through a consensus
meeting Each RCA case was randomly assigned
to 2 reviewers Human factors leading to partic-
ular AMEs were identified and confirmed when
2 reviewers reached agreement The distribution
of errors among tiers subitems and nanocodes
are provided with descriptive statistics () The
study was approved by the Institutional Review
Board of Cathay General Hospital
(CGH-P105095)
RESULTS AMEs related to laboratory testing and examina-
tion (n = 16) clinical care (n = 9) and medica-
tion (n = 7) were the most commonly observed
in the RCA Most AMEs in this cohort are
ranked as being SAC level 3 (n = 15) or 4 (n =
17) (Table 1)
Acts (Active Failures)
This tier of errors contains 3 subitems and 13
nanocodes In the 40 RCA cases perfor-
mance-based errors for 38 (95) and judgment
and decision-making errors for 35 (875) com-
prised the most common error types with viola-
tion for 6 (15) less common Procedure fol-
lowed incorrectly for 31 out of 38 (816) was
the most common performance-based problem
Inadequate real-time risk management for 24 out
of 35 (686) was the most common judgment
or decision error All of the rule violations were
workaround types for 6 out of 6 (100) (Figure
1)
Preconditions(Latent Failures)
This tier of errors has 9 subitems and 58 nano-
codes In the 40 RCA cases teamwork for 11
(275) and environmental for 8 (20) factors
contributed to most of the errors with mental
and physical state the next most common factor
for 7 (175) Communication for 9 out of 11
(818) and information relay for 8 out of 11
(727) were the most common issues related to
teamwork Few contributors mentioned failures
related to technical errors for 4 (50) or physi-
cal for 1 (125) environment Not paying at-
tention for 4 out of 7 (571) and negative habit
transfer for 4 out of 7 (571) were common
mental contributes noted for 7 (100) Overcon-
fidence was the most common problem related
to emotional status for 4 out of 7 (571) Fa-
tigue was observed in only 2 cases for 2 out of 2
physical problems (100) (Figure 2)
Supervision(Direct Supervisory Chain of
Command)
This tier of errors contains 3 subitems and 17
nanocodes In the 40 RCA cases inadequate
supervision for 14 (35) and inappropriately
planned operations for 11 (275) factors con-
tributed to most of the respective errors fol-
lowed by supervisory violations for 7 (175)
Supervisory or command oversights for 13 out
of 14 (929) were the most common sources of
supervision inadequacy Authorized unnecessary
hazards for 7 out of 11 (636) were the most
common inappropriately planned operations
Failure to enforce rules for 6 out of 7 (857)
was the most common supervisory violation
(Figure 3)
Organization Influence (Upper-Level Man-
agement)
This tier of errors contains 4 subitems and 18
nanocodes In the 40 RCA cases policy and
process issues for 10 (25) and resources prob-
lem for 8 (20) were major concerns Few of
the respective problems are related to climate
and cultural influences for 2 (5) or to person-
nel selection and staffing for 1 (25) Poorly
assessed organizational programs or policy risks
for 5 out of 10 (50) were the most common
policy and process problems Failure to provide
adequate operational information resources for 4
out of 8 (50) and command and control re-
source deficiency for 3 out of 8 (375) were
the main resource management problems Little
was revealed regarding organizational climate
and culture (n = 1 out of 2 50) or staffing for 1
out of 1 (100) (Figure 4)
DISCUSSION Health care is a complex system comprising
many high-reliability organizations (HROs) The
vulnerability of HROs stems from the participa-
tion of multidisciplinary teams in the processes
along a variety of patient care timelines How-
ever humans and systems are inherently prone
to errors the appropriate management of AMEs
is acknowledged to be the cornerstone of patient
safety AMEs should be reported investigated
analyzed and handled appropriately[14] Theo-
retically by analyzing the pattern of key defects
providers can fix errors and re-engineer their
care processes to reduce the possibility of AME
recurrence Taiwan established its nationwide
TPR in 2004 so far 7000 health care facilities
have participated and the database has accumu-
lated more than 055 million AMEs[11] Infor-
mation generated from the TPR database can
improve patient safety at individual organiza-
tional or even national levels However despite
relentless efforts few substantial improvements
have been achieved in patient safety [15-17]
Since its introduction in Taiwan in 2006 the use
of RCA for AMEs has encountered some diffi-
culties 1) No structural and standardized
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 102
framework exists for investigation
cross-institution variability and interrater relia-
bility are often ignored 2) Conclusions are often
subjective and corrective recommendations are
less actionable relying on individual reviewersrsquo
professional backgrounds and their experiences
3) Much focus on event reconstruction and oper-
ator performance means that factors relating to
human behavior organizational culture and
system weakness are not comprehensively ad-
dressed [671718] Traditionally attempts to
improve patient safety in the health care industry
are largely reactive in nature identifying and
correcting errors in care processes [1920]
Causes of defects are not thoroughly understood
Proactive approaches must be taken to address
systematic problems within a complex system
[720] Research suggests that human error is a
causal factor in the occurrence of AMEs AME
investigation targets have moved from skill defi-
ciency toward decision-making attitudes super-
visory factors and even organizational climate
or culture HFACS methodology is based on the
Swiss cheese model that also emphasizes active
and latent failures [921] The study provides
some noteworthy findings First most AMEs as
expected involve active failures such as failure
to follow procedure accidental operation of
equipment inadequate real-time risk manage-
ment and inappropriate action These are all
sharp ends in classic RCA environment physi-
cal and mental factors are less prevalent This
proves that retrospectively determining addi-
tional causal factors is difficult when infor-
mation has not been collected during preliminary
investigation (Figure 1) Second team-
work-related problems particularly in relation to
communication and information relay are well
addressed This may be attributed to the dec-
ade-long institution-wide routine crew resource
management training in the respective research
hospital (Figure 2) Third the HFACS success-
fully reflects the importance of supervisory roles
in the occurrence of AMEs and this cannot be
overlooked (Figure 3) Fourth latent failures
especially in organizational climate or cultural
dimensions have been less frequently addressed
in incident reports a limitation of traditional
RCA However the HFACS review suggests
room for improvement in resource allocation and
policy modification within the hospital The
results of studies can make the organization
think about how to improve the patient safety
and management process from the perspective of
human factors such as improving the comfort of
the working environment and replacing and
equipment resources to prevent personnel from
affecting the medical quality and patient safety
due to the environment or equipment Need to
appropriate assessment of applicability and ade-
quate training of manpower is required The
management and control of risks should be fully
evaluate and grasp resource management and
leaders need to participate in and promote medi-
cal quality and patient safety activities to en-
hance its culture (Figure 4) No panacea exists
to ensure patient safety and improvement targets
originate largely from event investigation find-
ings Unfortunately factors identified from
AMEs are often self-explanatory with little value
for further action correction Reinforcement of
policy or processes redundant education or
repetitious training are formulaic overprescribed
RCA recommendations The use of HFACS in
this study proves that a structural prospective
AME investigation format can potentially help
with proactive patient safety management We
suggest developing an interview guideline for
the routine use of HFACS as a complement to
RCA in every AME investigation This study is a
retrospective study The underlying human fac-
tors can be under-estimated owing to the lack of
related information in the original RCA reports
CONCLUSION The HFACS review in this study enhances our
understanding of human factors in AMEs that
had previously been insufficiently scrutinized
Aside from active process and communication
errors the HFACS enables the prospective in-
vestigation of latent supervisory organizational
or systematic problems that cannot be addressed
through traditional RCA
REFERENCES 1 T Brennan L Leape N Laird et al
Incidence of adverse events and
negligence in hospitalized patients results
of the Harvard Medical Practice Study I N
Engl J Med 1991324370-376
2 Wang CH Shih CL Chen WJ et al
Epidemiology of medical adverse events
perspectives from a single institute in
Taiwan J Formos Med Assoc
2016115434-439
3 Vincent C Simon R Sutcliffe K et al
Errors Conference Executive Summary
Acad Emerg Med 200071180-1182
4 Taitz J Genn K Brooks V et al
System-wide learning from root cause
analysis A report from the New South
Wales Root Cause Analysis Review
Committee Qual Saf Health Care
2010191-5
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 103
5 Hutchinson A Young TA Cooper KL et
al Trends in healthcare incident reporting
and relationship to safety and quality data
in acute hospitals results from the
National Reporting and Learning System
Qual Saf Health Care 2009185-10
6 Mitchell RJ Williamson AM Molesworth
B et al A review of the use of human
factors classification frameworks that
identify causal factors for adverse events
in the hospital setting Ergonomics
2014571443-1472
7 Gurses AP Ozok AA Pronovost PJ Time
to accelerate integration of human factors
and ergonomics in patient safety BMJ
Qual Saf 201221347-351
8 Health and Safety Executive Introduction
to human factors
httpwwwhsegovukhumanfactorsintro
ductionhtm
9 Wiegmann DA Shappell SA A human
error approach to aviation accident
analysis The human factors analysis and
classification system Burlington VT
Ashgate Publishing Ltd 2003
10 Yu-Hsun Cheng Sheng-Hui Hung
Tung-Wen Ko et al An Analysis of the
Reliability and Validity of Human Factors
Analysis Classification System in Medical
Adverse Events Journal of Healthcare
Quality 20191370-76
11 Taiwan Joint Commission on Hospital
Accreditation Taiwan Patient-Safety
Reporting System Annual Report 2017
New Taipei City Taiwan
12 Taiwan Patient Safety Net
httpwwwpatientsafetymohwgovtwCo
ntentzMessagesslistaspxSiteID=1ampMm
mID=621273300317401756
13 Government of Western Australia
Department of Health
httpsww2healthwagovauArticlesS_T
Severity-assessment-codes
14 Farley DO Haviland A Champagne S et
al Adverse-event-reporting practices by
US hospitals results of a national survey
Qual Saf Health Care 200817416-423
15 Shojania KG Thomas EJ Trends in
adverse events over time why are we not
improving BMJ Qual Saf
201322273-277
16 Levitt P Challenging the systems approach
why adverse event rates are not improving
BMJ Qual Saf 2014231051-1052
17 Kellogg KM Hettinger Z Shah M et al
Our current approach to root cause
analysis is it contributing to our failure to
improve patient safety BMJ Qual Saf
201726381-387
18 Khorsandi M Skouras C Beatson K et al
Quality review of an adverse incident
reporting system and root cause analysis of
serious adverse surgical incidents in a
teaching hospital of Scotland Patient Saf
Surg 2012621
19 Diller T Helmrich G Dunning S et al
The Human Factors Analysis
Classification System (HFACS) Applied to
Health Care Am J Med Qual
201429181-190
20 Carayon P Xie A Kianfar S Human
factors and ergonomics as a patient safety
practice BMJ Qual Saf 201423196-205
21 Reason J Human Error New York
Cambridge University Press 1990
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 104
TABLE
Table 1 Incidences by Category (N=40)
CategorySAC SAC 4 SAC 3 SAC 2 SAC 1 total
Laboratory and ex-
amination events
4 10 2 0 16 (400)
Clinical care event 6 2 1 0 9 (225)
Medication event 5 0 2 0 7 (175)
Surgery-related event 1 1 2 0 4 (100)
Transfusion-related
event
1 1 0 0 2 (50)
Tube event 0 1 0 0 1 (25)
Public accident 0 0 1 0 1 (26)
Total 17 (425) 15 (375) 8 (200) 0 40 (100)
SAC 1113 Severity Assessment Code SAC
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 105
FIGURES
Figure 1 Active Failures (N=40)
16 (167)
66 (1000)
640 (150)
235 (57)
735 (200)
2435 (686)
2435 (686)
3540 (875)
438 (105)
438 (105)
738 (184)
1938 (500)
3138 (816)
3840 (950)
0 5 10 15 20 25 30 35 40
Commits WidespreadRoutine Violation
Performs Work-Around Violation
Ignored a CautionWarning
Failure to Prioritize Tasks Adequately
Wrong Choice of Action During an Operation
Inadequate Real‐Time Risk Assessment
Rushed or Delayed a Necessary Action
Breakdown in Visual Scan
Over-ControlledUnder-Controlled AircraftVehicleSystem
Unintended Operation of Equipment
Procedure Not Followed Correctly
Performance-Based Errors
Judgment and Decision Making Errors
Violations
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 106
Figure 2 Preconditions (Latent Failures or Conditions) (N=40)
14 (250)
24 (500)
48 (500)
11 (1000)
18 (125)
840 (200)
0 5 10 15 20 25 30 35 40
Seat and Restraint System Problems
Instrumentation amp Warning System Issues
Noise Interference
Environment
Physical Environment
Technological Environment
27 (286)
27 (286)
27 (286)
37 (129)
47 (511)
47 (571)
77 (1000)
24 (500)
44 (1000)
47 (571)
12 (500)
22 (1000)
27 (286)
740 (175)
0 5 10 15 20 25 30 35 40
Technical or Procedural Knowledge Not Retained After Training
InterferenceInterruption
Task OverUnder Saturation
Distraction
Negative Habit Transfer
Not Paying Attention
Complacency
Overconfidence
Physical IllnessInjury
Fatigue
Physical and Mental State
Physical Problem
State of Mind
Mental Awareness
211 (182)
311 (273)
311 (273)
411 (364)
811 (7227)
911 (818)
1140 (275)
0 5 10 15 20 25 30 35 40
Inadequate Task Delegation
TaskMission PlanningBriefingDebriefing Inadequate
Failure of CrewTeam Leadership
StandardProper Terminology Not Used
Critical Information Not Communicated
Failed to Effectively Communicate
Teamwork
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 107
Figure 3 Supervision (Direct Supervisory Chain of Command) (N=40)
Figure 4 Organization Influence (Upper-Level Management Command Level) (N=40)
114 (71)
114 (71)
214 (143)
314 (214)
1314 (929)
1440 (350)
511 (455)
511 (455)
711 (636)
1140 (275)
47 (571)
67 (857)
740 (175)
0 5 10 15 20 25 30 35 40
Selected Individual with Lack of Proficiency
Improper Role‐modeling
Failed to Provide Proper Training
Failed to IdentifyCorrect Risky or Unsafe Practices
SupervisoryCommand Oversight Inadequate
Performed Inadequate Risk Assessment ‐Formal
Selected Individual with Lack of Current or Limited Experience
Authorized Unnecessary Hazard
Allowing Unwritten Policies to Become Standard
Failure to Enforce Existing Rules
Supervisory Violations
Planned Inappropriate Operations
Inadequate Supervision
12 (500)
12 (500)
240 (50)
110 (100)
510 (500)
1040 (250)
11 (1000)
140 (25)
18 (125)
18 (125)
38 (35)
48 (500)
840 (200)
0 5 10 15 20 25 30 35 40
Organizational Over-confidence or Under-confidence in Equipment
Organizational Culture (attitude actions) Allows for Unsafe TaskMission
Purchasing or Providing Poorly Designed or Unsuitable Equipment
Organizational ProgramPolicy Risks not Adequately Assessed
Failure to Provide Adequate Manning Staffing Resources
Failure to remove inadequate worn-out equipment in timely manner
Inadequate infrastructure
Command and control resources are deficient
Failure to provide adequate operational information resources
Resource Problems
Personnel Selection amp Staffing
Policy and Process Issues
ClimateCulture Influences
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 108
Supplement Table 1- HFACS Content of Human Factor Analysis Classifi-
cation System [9] Tier main level sub-item nano code
Tier 1 Unsafe Acts
Perfor-
mance-Based
Errors
Unintended operation of equipment
Checklist not followed correctly
Procedure not followed correctly
Over-controlledunder-controlled aircraftvehiclesystem
Breakdown in visual scan
Rushed or delayed a necessary action
Judgment amp De-
cision-Making
Errors
Inadequate real‐time risk assessment
Failure to prioritize tasks adequately
Ignored a cautionwarning
Wrong choice of action during an operation
Violations
Performs work-around violation
Commits widespreadroutine violation
Extreme violation-lack of discipline
Tier 2 Preconditions
Environment
Physical environment
Environmental conditions affecting vision
Vibration effects vision or balance
Heatcold stress impairs performance
External force of object impeded an individualrsquos
movement
Lights of other vehiclevesselaircraft affected vision
Noise interference
Technological environment
Seat and restraint system problems
Instrumentation amp warning system issues
Visibility restrictions (not weather related)
Controls and switches are inadequate
Automated system creates unsafe situation
Workspace incompatible with operation
Personal equipment interference
Communication equipment inadequate
Physical and
Mental State
Physical problem
Substance effects (alcohol supplements medications
drugs)
Loss of consciousness (sudden or prolonged onset)
Physical illnessinjury
Fatigue
Inadequate adaptation to darkness
Dehydration
Body sizemovement limitations
Physical strength amp coordination (inappropriate for
task demands)
Nutritiondiet
State of mind
Psychological problem
Life stressors
Emotional state
Personality style
Overconfidence
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 109
Pressing
Complacency
Motivation
Motivational exhaustion (burnout)
Sensory misperception
Motion illusion-kinesthetic
Turning illusionbalance-vestibular
Visual illusion
Misperception of changing environment
Misinterpreted misread instrument
Misinterpretation of auditorysound cues
Spatial disorientation
Temporaltime distortion
Mental awareness
Not paying attention
Fixation
Task overunder saturation
Confusion
Negative habit transfer
Distraction
Geographically lost
Interferenceinterruption
Technical or procedural knowledge not retained after
training
Inaccurate expectation
Teamwork
Failure of crewteam leadership
Inadequate task delegation
Rankposition intimidation
Lack of assertiveness
Critical information not communicated
Standardproper terminology not used
Failed to effectively communicate
Taskmission planningbriefingdebriefing inadequate
Tier 3 Supervision
Supervisory Vio-
lations
Failure to enforce existing rules
Allowing unwritten policies to become standard
Directed individual to violate existing regulations
Authorized unqualified individuals for task
Planned Inappro-
priate Operations
Directed task beyond personnel capabilities
Inappropriate team composition
Selected individual with lack of current or limited experience
Performed inadequate risk assessment ‐formal
Authorized unnecessary hazard
Inadequate Su-
pervision
Supervisorycommand oversight inadequate
Improper role‐modeling
Failed to provide proper training
Failed to provide appropriate policyguidance
Personality conflict with supervisor
Lack of supervisory responses to critical information
Failed to identifycorrect risky or unsafe practices
Selected individual with lack of proficiency
Tier 4 Organizational
Influences
Resource Prob-
lems
Command and control resources are deficient
Inadequate infrastructure
Fu-Jen Journal of Medicine Vol 3 No 2 2020
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Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 110
Failure to remove inadequate worn-out equipment in timely
manner
Failure to provide adequate operational information resources
Fail to provide adequate funding
Personnel Selec-
tion amp Staffing
Personnel recruiting amp selection policies are inadequate
Failure to provide adequate manning staffing resources
Policy amp Process
Issues
Pace of ops-tempoworkload
Organizational programpolicy risks not adequately assessed
Provided inadequate procedural guidance or publications
Organizational (formal) training is inadequate or unavailable
Flawed doctrinephilosophy
Inadequate program management
Purchasing or providing poorly designed or unsuitable equip-
ment
ClimateCulture
Influences
Organizational culture (attitude actions) allows for unsafe
taskmission
Organizational over-confidence or under-confidence in equip-
ment
Unit missionaircraftvehicleequipment change or unit deacti-
vation
Organizational structure is unclear or inadequate
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 111
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
以 HFACS重新檢視根本原因分析案例挖掘造成醫療不良
事件之人為因素
鄭伃洵 1洪聖惠 12柯彤文 3王拔群 14
中文摘要
背景醫療不良事件(AMEs)的管理是促進病人安全的基石根本原因分析
(RCA)是探討重大病人安全不良事件問題但是由於無法解釋更廣泛的因素而受
到限制本研究使用人為因素分類與分析工具(HFACS)回溯審視醫療不良事件
以了解影響醫療不良事件的人為因素及各層面中錯誤原因之分佈或系統性問題
方法本研究回溯 2012-2016年間有做過根本原因分析之醫療不良事件以連續
性取樣方式(continuous sampling)收集 40例醫療不良事件以人為因素分類與分
析工具(HFACS)去系統性的挖掘每件案例發生錯誤之原因結果在行為層面中
分析結果主要為基礎技能錯誤(95)判斷和決策錯誤(875)其中在基礎技能
錯誤當中以未依程序作業執行(816)及未如預期設備操作(50)佔多數判斷和
決策錯誤中以現場風險評估不確實(686)及採取錯的步驟行為(686)佔多數
而在先決條件層面中以團隊合作(275)為主要因素包含溝通不良(818)及重
要訊息未以正確的方式即時傳達(727)佔多數在監督層面當中以監督不周
(929)或監督不妥當(929)為主要因素在組織政策和流程方面(50)以組織
系統的政策風險未充分評估(35)為主要因素結論本研究進一步了解醫療不
良事件在過去使用根本原因分析未探討到的人為因素反映出潛在的監督組織
行為或系統性的問題促進病人安全預防錯誤再發生
關鍵字病人安全醫療不良事件根本原因分析人為因素
1國泰醫療財團法人國泰綜合醫院 品質管理部
2國立臺灣大學健康政策與管理研究所
3振興醫療財團法人振興醫院 醫療品質管理中心
4輔仁大學醫學院
通訊作者王拔群 電子信箱 drtonyseednettw
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin 112
Submitted January 20 2020
Final version accepted April13
2020
Case Report
Juvenile Caruncular Atypical Lymphoid
Proliferation ndash A Rare Case Report
Cite as Hua-Wei Shih Yu-Chi Lin
Juvenile Caruncular Atypical
Lymphoid Proliferation ndash A Rare
Case Report Fu-Jen Journal of
Medicine 3(3) 112-119 2020
DOI
103966181020932020091803003
Hua-Wei Shih1 Yu-Chi Lin
1
1Department of Ophthalmology Shin Kong Wu Ho-Su Memorial Hos-
pital Taipei City Taiwan
Corresponding author E-mail address
yuchi067gmailcom (Yu-Chi Lin)
ABSTRACT
Lesions of the caruncle are very rare Most caruncular lesions are benign though there were still few reported malignant lesions Ocular adnexal lymphoproliferative disease (OALD) one of the differential diagnosis of caruncular lesion is seldom seen in young pa-tient In this article we report a 16-year-old boy with recurrent caruncular atypical lym-phoid proliferation We discuss the epidemiology clinical features images histomorpholo-gy and treatment between ocular adnexal lymphomas (OAL) and reactive lymphoid hyper-plasia (RLH)
Keywords caruncular lesion ocular adnexal lymphoproliferative disease ocular adnexal lymphoma
reactive lymphoid hyperplasia atypical lymphoid proliferation
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
113
INTRODUCTION Lesions of the caruncle are very rare Differen-
tial diagnosis includes nevus myeloproliferative
disorders tumors inflammation infection cysts
vascular lesions and fibrous Biopsy is essential
for diagnosis Levy J et al reported ocular ad-
nexal lymphoproliferative disease (OALD) was
relatively uncommon diagnosis among caruncu-
lar lesions [1]
OALD was seldom described in Asian popula-
tion especially for young age C-Y Cheng re-
ported age-standardized incidence of ocular
adnexal lymphomas (OAL) in Taiwan from 1979
to 1996 was below 07 per million per year and
mean age was 531 years old [2] In 2015 five
Taiwanese cases of OAL whose age ranging
from 45 to 64 were presented [3] However
there were few cases of conjunctival OAL or
RLH in Chinese pediatric patient
Here we present a case of 16-year-old boy with a
caruncular mass at his left eye with recurrence
one month after excision We describe his clini-
cal symptoms photographs pathological results
management and follow-up clinical course in
this report
CASE REPORT A 16-year-old healthy boy presented a mass
lesion at his left eye caruncle accompanied with
the symptom of tearing for one month (Figure 1)
He had no ocular pain no itchiness no blurred
vision no night sweating no fever and no body
weight loss The patient denied systemic diseas-
es and histories of surgery His bilateral best
corrected visual acuity (BCVA) were 66 and
intraocular pressure (IOP) were both within
normal range There were no remarkable find-
ings for his cornea lens fundus and physical
examination Excision was performed and the
mass was soft with fluid inside therefore con-
junctival pyogenic cyst was our initial diagnosis
However one month after the excision a pro-
truding mass recurred at the patientrsquos nasal can-
thus of left eye (Figure 2) There were some
differences compared to previous condition At
the first time the soft mass was contained in a
well-defined cyst wall which more favored py-
ogenic granulation However after short period
of recurrence solid consistency and unclear
margin were found which favored malignancy
Besides the mass partially involved beyond the
gray line of nasal part lower eyelid whereas last
time the cyst mainly extended from conjunctiva
of caruncle The second excisional biopsy was
performed Pathologic examination demonstrat-
ed abundant atypical lymphoid proliferation
(Figure 3A 3B) Immunohistochemical studies
showed that the lymphoid aggregation was
composed predominantly of CD20-positive cells
(Figure 3C) focal positive staining of CD3
(Figure 3D) CD5 CD23 CD10 and negative
staining of cyclin-D1 Unfortunately the cellular
morphology was difficult to be evaluated due to
marked crushing artifact Thus malignant lym-
phoma cannot be excluded totally
Orbital computed tomography (CT) showed a
lesion of soft tissue density at medial canthus of
left orbit without obvious nasolacrimal duct or
bony invasion (Figure 4A) Magnetic resonance
imaging (MRI) with contrast showed strong
enhancement at left medial canthus region (Fig-
ure 4B) There was no remarkable finding in the
systemic workup including complete blood
count and differential count biochemical pro-
files and 18F-fluoro-2-deoxyglucose positron
emission tomographycomputed tomography
(18F-FDG PETCT) indicating no evidence of
systemic involvement
After the second excision we preferred con-
servative management for him due to the uncer-
tainty of malignancy and to avoid side effects
from aggressive treatment No sign of recurrence
was noted after 10 months of observation The
follow-up photo was taken at three months after
the second operation (Figure 5)
DISCUSSION Ocular adnexal lymphoproliferative disease
(OALD) consists of the spectrum of lymphoid
disease affecting the tissues surrounding the eye
including ocular adnexal lymphomas (OAL) and
lymphoid hyperplasia (LH) [4] The conjunctiva
is an important location for extranodal lympho-
ma development which comprises 25 of OAL
[5]
OAL can be grouped into two categories based
on their appearance of cells under the micro-
scope low-grade and high-grade [6] Extranodal
marginal zone lymphoma of mucosa-associated
lymphoid tissue (EMZLMALT) is the most
common subtype of OAL followed by follicular
lymphoma [7-9] Both of the above are
low-grade lymphomas
LH can be further divided by histopathology into
reactive lymphoid hyperplasia (RLH) and atypi-
cal lymphoid hyperplasia (ALH) RLH has to-
tally benign morphology and immunophenotype
whereas ALH has borderline lesions between
RLH and lymphoma [10] OAL and LH are
mostly seen in patients with age between 50-70
years old There are rare cases in pediatric group
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
114
[71011] In the C-Y Chengrsquos statistical report of
OAL in Taiwan only 8 patients were younger
than 15 years old among the 101 cases of ocular
lymphoma [2] According to an US study inci-
dence rates of OAL were analyzed in different
age groups the group of age over 50 had the
highest incidence rate of 574 per million per-
son-years while the 0-19 age group had the
lowest incidence rate of 009 per million per-
son-years [12] The incidence of LH was even
less than OAL [13]
Patients with OALD may be asymptomatic or
with symptoms of proptosis eyelid swelling a
palpable painless mass or conjunctival salmon
patch Diplopia visual loss pain or inflamma-
tion occurred less frequently implying more
aggressive features [714]
Orbital LH is not distinguishable from low-grade
lymphoma radiologically They both typically
present a round or lobulated mass that diffusely
moderately enhances with contrast and usually
shows homogenous hypointense or isointense to
muscle barely invasion to bone or nervous sys-
tem [10] Atypical appearances including inho-
mogeneous calcification or bony changes may
be seen in high-grade lymphoma case reports
such as ocular adnexal diffuse large B-cell lym-
phoma (DLBCL) which is one of the more ag-
gressive type of OAL [7] Whole body PET is
used for not only the evaluation of systemic
involvement but also the standard for staging
lymphoma Our patientrsquos image studies revealed
neither obvious local invasion nor systemic ma-
lignancy indicating high-grade lymphoma was
less likely Low-grade lymphoma and benign
reactive lymphoid hyperplasia were still under
consideration
Histomorphology analysis and immunohisto-
chemistry (IHC) are essential for diagnosis
Flow cytometry and polymerase chain reaction
(PCR) technique are also applied to help differ-
entiate from RLH and OAL [1016] Our case
had immunohistochemical profile of positivity
for CD20 predominantly positivity focally for
CD3 CD5 CD10 CD23 and negativity for cy-
clin-D1 BCL-6 staining was not performed in
our casersquos biopsy Thus according to the IHC
report RLH ALH and follicular lymphoma are
probable diagnosis of our patient
Radiation therapy is the standard treatment for
low-grade OAL that is classified as T1N0M0 or
T2N0M0 according to the AJCC criteria [15]
İncesoy-Ouml zdemir S et al reported a 10-year-old
boy diagnosed of MALT lymphoma who was
treated with local radiotherapy (36 Gy) and
there were no local or systemic recurrences dur-
ing his nearly four-year follow-up [17] Another
case report represented a 21-year-old man of
conjunctival follicular lymphoma treated with
surgical excision only showing no evidence of
recurrence after 8 months follow-up [18] Other
treatment options for pediatric and juvenile OAL
were performed in some case reports including
intravenous rituximab intralesional interfer-
on-α-2b topical interferon a6 systemic doxycy-
cline surgical excision and postoperative local
cryotherapy [15]
Treatment for young conjunctival RLH was less
discussed in the past In a case series article
three children (9 13 14 years old respectively)
of RLH received surgical resection without fur-
ther postoperative management and no signs of
recurrence were noted during follow-up [19]
Short-term topical and oral corticosteroids after
surgical excision were prescribed in two pediat-
ric RLH patients for their small residual mass
However poor response in both cases was nota-
ble [20]
Our patient declined to receive radiotherapy or
any further postoperative treatment mainly due
to his concerning of possible side effects (such
as dry eye and cataract)
CONCLUSION We present a rare case of caruncle mass in this
report OALD is one of the relatively uncommon
diagnosis among caruncular lesions OALD
includes benign RLH and malignant OAL
which are both mainly seen in elderly patients
even rarer in pediatric or juvenile group
The standard treatment for low-grade OAL and
RLH in young patents are still debatable How-
ever long-term follow-up is suggested for both
OAL and RLH patients Though RLH has a be-
nign and self-limited course risk of malignant
transformation is possible
REFERENCES 1 Levy J Ilsar M Deckel Y et al Lesions of
the caruncle a description of 42 cases and
a review of the literature Eye
200923(5)1004-1018
2 C-Y Cheng and W-M Hsu Incidence of
eye cancer in Taiwan an 18-year review
Eye 200418152-158
3 Chui-Lien Tsen Muh-Chiou Lin
Youn-Shen Bee et al Ocular adnexal
lymphoma Five case reports and a
literature review Taiwan Journal of
Ophthalmology 20155(2)99-102
4 Liesegang TJ Ocular adnexal
lymphoproliferative lesions Mayo Clin
Proc 199368(10)1003-1010
5 Kirkegaard MM Coupland SE Prause JU
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
115
et al Malignant lymphoma of the
conjunctiva Surv Ophthalmol
201560(5)444-458
6 Stacy RC Jakobiec FA Schoenfield L et
al Unifocal and multifocal reactive
lymphoid hyperplasia vs follicular
lymphoma of the ocular adnexa Am J
Ophthalmol 2010150(3)412-426
7 Sullivan TJ Ocular Adnexal
Lymphoproliferative Disease In Guthoff
RF Katowitz JA eds Oculoplastics and
Orbit Berlin Heidelberg Springer
20101-19
8 White Valerie A Understanding and
Classification of Ocular Lymphomas
Ocular Oncology and Pathology
20195379-386
9 Stefanovic A Lossos IS Extranodal
marginal zone lymphoma of the ocular
adnexa Blood 2009114(3)501-510
10 Andrew NH Coupland SE Pirbhai A et al
Lymphoid hyperplasia of the orbit and
ocular adnexa A clinical pathologic review
Surv Ophthalmol 201661(6)778-790
11 Ferry JA1 Fung CY Zukerberg L et al
Lymphoma of the ocular adnexa A study
of 353 cases Am J Surg Pathol
200731(2)170-184
12 WM Hassan MS Bakry HM Hassan et al
Incidence of orbital conjunctival and
lacrimal gland malignant tumors in USA
from Surveillance Epidemiology and End
Results 1973-2009 Int J Ophthalmol
20169(12)1808-1813
13 Ajay A Rao John H Naheedy James Y-Y
Chen et al A Clinical Update and
Radiologic Review of Pediatric Orbital
and Ocular Tumors Journal of Oncology
2013(9)975908
14 Sullivan TJ Whitehead K Williamson R
et al Lymphoproliferative disease of the
ocular adnexa a clinical and pathologic
study with statistical analysis of 69
patients Ophthal Plast Reconstr Surg
200521177-188
15 Tanenbaum RE Galor A Dubovy SR et al
Classification diagnosis and management
of conjunctival lymphoma Eye Vis (Lond)
2019622
16 Olga Klavdianou Georgios Kondylis
Vasileios Georgopoulos et al Bilateral
benign reactive lymphoid hyperplasia of
the conjunctiva a case treated with oral
doxycycline and review of the literature
Eye Vis (Lond) 2019626
17 İncesoy-Ouml zdemir S Yuumlksek N Bozkurt C
et al A rare type of cancer in children
extranodal marginal zone B-cell (MALT)
lymphoma of the ocular adnexa Turk J
Pediatr 201456(3)295-298
18 Lynn J Poole Perry Frederick A Jakobiec
Peter A D Rubin Conjunctival Pediatric
Follicular Lymphoma Arch Ophthalmol
2012130(7)941-943
19 Abdullah Al-Mujaini Upender Wali
Anuradha Ganesh1 et al Ocular Adnexal
Reactive Lymphoid Hyperplasia in
Children Middle East Afr J Ophthalmol
201219(4)406-409
20 McLeod SD Edward DP Benign
lymphoid hyperplasia of the conjunctiva in
children Arch Ophthalmol
1999117(6)832-835
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
116
FIGURES
Figure 1 Slit lamp image of a mass lesion at the patientrsquos left eye caruncle for one month
Figure 2 One month after the first excision a protruding mass recurred at the patientrsquos nasal canthus
of left eye It partially involved beyond the gray line of nasal part lower eyelid
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
117
Figure 3 Histomorphology analysis and immunohistochemistry study of the caruncular lesion Abun-
dant atypical lymphoid proliferation presented in low-power photomicrograph (A) and
high-power photomicrograph (B) under hematoxylin-eosin staining The lymphoid aggrega-
tion was composed predominantly of CD20-positive cells (C) and focal positive staining of
CD3 (D)
Figure 4 Non-contrast orbital computed tomography showed a lesion of soft tissue density at medial
canthus of left orbit without obvious nasolacrimal duct or bony invasion (A) Magnetic reso-
nance imaging with contrast showed strong enhancement at left medial canthus region (B)
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
118
Figure 5 The follow-up photo were taken at three months after the second excision showing no signs
of recurrence
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
119
Juvenile Caruncular Atypical Lymphoid Proliferation ndash A Rare Case Report
罕見病例報告mdash青少年之淚阜非典型淋巴增生
施驊瑋 1林友祺 1
中文摘要
淚阜病灶相當罕見大部分為良性病灶眼睛及附屬結構淋巴增生疾病為其
鑑別診斷之一非常少見於年輕人或兒童我們報告一位 16歲的健康男性因
左眼淚阜無痛性腫塊接受切除手術卻於術後一個月復發執行第二次切除手術
後門診追蹤十個月未再復發此案例表現了部分良性與部分惡性腫瘤的特徵
我們針對反應性淋巴增生眼睛及附屬結構淋巴癌兩個疾病做討論及文獻回顧
關鍵字淚阜病灶眼睛及附屬結構淋巴增生疾病眼睛及附屬結構淋巴癌反
應性淋巴增生非典型淋巴增生
1 新光吳火獅紀念醫院眼科
通訊作者林友祺 電子信箱 yuchi067gmailcom
Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh 120
Submitted March 26 2020
Final version accepted April 16
2020
Case Report
Hyperacute intramembranous hemor-
rhage after burr hole craniostomy for
chronic subdural hematoma
Cite as Meng-Chi Lin Jui-Ming
Sun Yu-Hao Chen Cheng-Ta
Hsieh
Hyperacute intramembranous
hemorrhage after burr hole crani-
ostomy for chronic subdural he-
matoma Fu-Jen Journal of Medi-
cine 3(4) 120-125 2020
DOI
103966181020932020091803004
Meng-Chi Lin1 Jui-Ming Sun23 Yu-Hao Chen24 Cheng-Ta
Hsieh567
1Department of Surgery Zuoying Branch Kaohsiung Armed Forces
General Hospital Kaohsiung 813 Taiwan 2Section of Neurosurgery Department of Surgery Chia-Yi Christian
Hospital Chia-Yi City 600 Taiwan 3Department of Biotechnology Asia University Taichung City 41354
Taiwan 4Chung-Jen Junior College of Nursing Health Sciences and Manage-
ment Chia-Yi Country 62241 Taiwan 5Division of Neurosurgery Department of Surgery Sijhih Cathay Gen-
eral Hospital New Taipei City 22174 Taiwan 6Department of Medicine School of Medicine Fu Jen Catholic Univer-
sity New Taipei City 24205 Taiwan 7Department of Neurological Surgery Tri-Service General Hospital
National Defense Medical Center Taipei 114 Taiwan
Corresponding author E-mail address
nogormail2000comtw (Cheng-Ta Hsieh)
ABSTRACT
Burr hole craniostomy with closed-system drainage is an effective and common neurosurgical procedure to manage chronic subdural hematoma Postoperative hem-orrhage a well-known but infrequent complication may result in increased neurolog-ical deficits However hyperacute intramembranous hemorrhage within the inner and outer membrane of hematoma after burr hole craniostomy with irrigation and closed-system drainage has not been described previously Herein we report a case of postoperative spontaneous hyperacute intramembranous hemorrhage after burr hole craniostomy with closed-system drainage to manage a chronic subdural hematoma we subsequently discuss the possible pathophysiological mechanisms and review the relevant literature
Keywords Chronic subdural hematoma acute subdural hematoma bleeding burr hole craniostomy
drainage
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Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh
125
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
慢性硬腦膜下出血進行鑽顱引流手術造成超急性夾膜內出
血
林孟楫 1孫瑞明 23陳昱豪 24謝政達 567
中文摘要
鑽顱併封閉系統引流手術是治療慢性硬腦膜下出血患者一種有效且常見的
神經外科手術方式術後出血可能導致神經功能缺損惡化是眾所周知但不常見
的併發症之一然而至今仍未有鑽孔併封閉系統引流造成原本慢性硬腦膜血
塊內膜和外膜間急性夾膜間出血案例在這裡我們報告一例慢性硬腦膜下出
血病患者接受鑽顱併封閉系統引流手術治療造成術後急性夾膜間出血我們在
本文中討論可能的致病機制並回顧相關文獻
關鍵字慢性硬腦膜下出血急性硬腦膜下出血出血鑽顱術引流
1國軍高雄總醫院左營分院 外科部
2崇仁醫護管理專科學校
3亞洲大學 生物科技學系
4戴德森醫療財團法人嘉義基督教醫院 外科部 神經外科
5汐止國泰綜合醫院 神經外科
6輔仁大學 醫學系
7 國防醫學院 三軍總醫院 神經外科
通訊作者謝政達 電子信箱 nogormail2000comtw
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
126
Submitted January 21 2020
Final version accepted July 08
2020
Case Report
Hamartoma of the breast A case report
Cite as Hsuan-An Chen
Cheng-Yu Lo Shih-Hung Huang
Chin-Lung Lin
Hamartoma of the breast A case
report Fu-Jen Journal of Medicine
3(5) 126-130 2020
DOI
103966181020932020091803005
Hsuan-An Chen1 Cheng-Yu Lo
3 Shih-Hung Huang
3 Chin-Lung
Lin2
1Department of Surgery Cathay General Hospital Taipei Taiwan
2Department of General Surgery Cathay General Hospital Taipei Tai-
wan
3Department of Pathology Cathay General Hospital Taipei Taiwan
Corresponding author E-mail address
lungyungmailcom (Chin-Lung Lin)
ABSTRACT
Breast hamartoma is an uncommon benign tumor rarely associated with malignancy An
excision and histological examination is necessary for the differential diagnosis We report
a case of a 49-year-old female patient presenting with a lump in the right breast Ultrasound
examination which demonstrated a 4411 cm hypoechoic lesion with lipoma Partial mas-
tectomy was arranged and the diagnosis of a hamartoma was confirmed by the histological
examination
Keywords Breast tumor Hamartoma Ultrasound
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
127
INTRODUCTION The hamartoma is a benign tumor-like lesion
that can affect various organs of the body in-
cluding lungs kidneys skin and more rarely the
breast In 1981 the hamartomas were recognized
in the WHO classification[1] They are defined
as well-demarcated mass of mammary ducts and
lobules containing varying amounts of fibrous
and adipose tissue and producing a distinctive
mammographic image
CASE REPORT A 49 year-old female had past history of left
breast mastitis with abscess status post partial
mastectomy This time she presented to our out
patient clinic for breast examination Physical
examination revealed a painless palpable mova-
ble and painless lump at upper outer quadrant of
right breast The risk of breast cancer was not
noted and the patient did not have any family
history of breast cancer The patient also denied
any trauma history before Ultrasound examina-
tion was arranged which demonstrated a 4411
cm hypoechoic lesion with lipoma at 3 oclock 2
cm from nipple of right breast and multiple hy-
poechoic nodules of various size in both breasts
and there was no suspicious axillary lymph
nodes noted (Figure1) Surgical treatment was
arranged partial mastectomy of right breast
harmartoma was successfully performed A 32 x
31 x 21 cm tumor was completely excised
Grossly examination showed a gray to yellow
and firm to fatty The diagnosis of a hamartoma
was confirmed by the histological examination
Microscopically sections of the breast lesion
show mammary hamartoma composed of ducts
lobules with interlobular fibrous tissue and adi-
pose tissue Fibrocystic change apocrine meta-
plastic ducts and scattered foci of adenosis are
noted The overall lobulocentric architecture and
the 2-cell pattern of the epithelium are preserved
columnar cell change and focal microcalcifica-
tion are present (Figure2) Based on submitted
biopsy specimen in-situ or invasive tumor cells
are not identified
DISCUSSION Hamartoma of the breast is a benign tumor like
nodule it was also known as fibroadenolipoma
lipofibroadenoma or adenolipoma based on its
predominant components It was composed of
varying amounts of glandular adipose and fi-
brous tissue[2] Hamartomas were first described
in 1971 by Arrigoni et al in a study of 10 patients
which breast tumors clinically and grossly re-
sembled fibroadenomas[3]
A higher predominance of tumors exists in fe-
males compared with males Hamartomas are
slowly-growing lesions with the diameter rang-
ing from 2 cm to 5 cm sometimes hamartomas
can reach giant diameter [4]
The clinical diagnosis of hamartoma is based on
the findings from mammography sonography
and histology examinations The hamartomas are
usually incidentally diagnosed by the women
older than 40 year-old starting mammography
screening
On physicial examination harmatomas are usu-
ally occult painless they may be as large mo-
bile soft to firm masses[5] Ultrasound showed
well capsulated mass with echogenic rim and
internal heterogeneity Mammography exam
showed well-circumscribed round to oval
masses containing fat and soft tissue densities
with a thin radiopaque pseudocapsule The
pseudocapsule results from displacement of
breast parenchyma by the tumor [56] In Pa-
thology finding microglandular adenosis is pre-
sent in fibroadipose stroma surrounded by a thin
fibrous capsule It composed of a combination of
epithelial and stromal elements usually with
normal ducts or lobules although variations of
normal tissue may also be seen Fibroadenoli-
poma myoid hamartoma and chondrolipoma are
histological variations of hamartomas depend-
ing on the proportion of normal breast tissue
elements[7]
Malignancy associated with hamartomas are
very rare[8] However it has been reported
hamartomas develop into carcinoma Malignant
transformation can occur as a result of cellular
atypia in the epithelial component of the mass[9]
Surgical removal is the curative method for
breast hamartomas[10] Diagnostic material such
as mammography ultrasonography or core nee-
dle biopsy may not give the definitive diagnosis
Therefore surgical excision and histological
examination is necessary for differential diagno-
sis[111213]
Although it is rare hamartoma can be seen along
with malignancy as it is formed from similar
components of breast tissue Therefore careful
diagnosis and appropriate management including
surgery are required
REFERENCES 1 World Health Organization (1981)
Histological typing of breast tumors In
International histological classification of
tumors 1981 2nd ed
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
128
2 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11435ndash449
2006
3 ArrigoniMG DockertyMB JuddES
The identificationand treatment of
mammary hamartoma Surg Gynecol
Obstet1971 133 577-82
4 Sanal HT Ersoz N Altinel O Unal E Can
C Giant hamartoma of the breast Breast J
2006 12 84-85
5 Feder JM de Paredes ES Hogge JP
Wilken JJ Unusual breast lesions
radiologic-pathologic correlation
Radiographics 1999 19S11ndashS26
6 Murat A Ozdemir H Yildirim H Poyraz
AK Ozercan R Hamartoma of the breast
Australas Radiol 200751 Spec NoB37ndash
9
7 Fisher CJ Hanby AM Robinson L Millis
RR Mammary hamartoma-a review of 35
cases Histopathology 1992 20 99-106
8 Choi N Ko ES Invasive ductal carcinoma
in a mammary hamartoma case report and
review of the literature Korean J Radiol
2010 Nov-Dec11(6)687-91
9 Lee EH Wylie EJ Bourke AG Bastiaan
De Boer W Invasive ductal carcinoma
arising in a breast hamartoma two case
reports and a review of the literature Clin
Radiol 2003 58 80-3
10 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11 435 ‑449
2006
11 Coyne J Hobbs FM Boggis C Harland R
Lobular carcinoma in a mammary
hamartoma J Clin Pathol 199245936ndash
937
12 G M K Tse B K B Law T K F Ma A B W
Chan Hamartoma of the breast a
clinicopathological review J Clin Pathol
200255951ndash954
13 RAAmir SSheikh BreasthamartomaA
report of 14cases of an under-recognized
and under-reported entity International
Journal of Surgery Case Reports
22(2016)1ndash4
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
129
FIGURES
Figure 1 Ultrasound shows a 4411 cm hypoechoic lesion with lipoma at 3 oclock 2 cm from nipple
of right breast
Figure 2 Photomicrograph shows mammary hamartoma composed of ducts lobules with interlobular
fibrous tissue and adipose tissue
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
130
Hamartoma of the breast A case report
乳房錯構瘤罕見個案報告
陳宣安 1羅承裕 3黃世鴻 3林錦龍 2
中文摘要
乳房錯構瘤是一種罕見之乳房良性腫瘤切除手術及病理化驗來做鑑別診斷
我們報告一位 49歲女性以可觸摸到無痛性右側乳房腫塊為臨床表徵超音波
看到一個邊緣清楚低迴音的腫塊病患接受手術切除病灶病理診斷證實為乳
房錯構瘤
關鍵字乳房腫瘤錯構瘤超音波攝影
1國泰綜合醫院外科部
2國泰綜合醫院一般外科
3國泰綜合醫院病理科
通訊作者林錦龍 電子信箱 lungyungmailcom
Fu-Jen Journal of Medicine
Mission and Goals
The Fu-Jen Journal of Medicine (FJJM) is a peer-reviewed journal which
aims to enhance research quality of staffs in the College of Medicine Fu Jen
Catholic University The journal publishes original investigations across a
wide range of medical disciplines including original research articles in basic
and clinical sciences case reports review articles brief reports and letter
to the editor FJJM is now issued by the Center of Medical Education in the
College of Medicine Fu Jen Catholic University To promote journal quality
the manuscript submitted to FJJM after August first 2015 has to be prepared
in English to meet the international standards
Issue Date
Publication Date
Institution
December 01 2003
September 30 2020
College of Medicine Fu Jen Catholic University
Honorable publisher Han-Sun Chiang
Publisher Ping-Keung Yip
Editor-in-chief Ming-Chieh Ma
Associate Editors Yu-Wen Lin
Editors
Telephone (02) 2905-3477
Address Center for Medical Education College of Medicine Fu Jen
Catholic University
No 510 Zhongzheng Rd Xinzhuang Dist New Taipei City
24205 Taiwan
Su-Jane Wang Chi-Chung Wang Chih-Ming Ho
Yih-Jing Lee Chih-Shung Wong Tze-Wah Kao
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- 9月封面
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-
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang
99
Submitted October 11 2019
Final version accepted February
02 2020
Original Research Article
Human Factors Underlying Adverse
Medical Events Revisit Root Cause Anal-
ysis Cases Using the HFACS
Cite as Yu-Hsun Cheng
Sheng-Hui Hung Tung-Wen Ko
Pa-Chun Wang
Human Factors Underlying Ad-
verse Medical Events Revisit
Root Cause Analysis Cases Using
the HFACS Fu-Jen Journal of
Medicine 3(2) 99-111 2020
DOI
103966181020932020091803002
Yu-Hsun Cheng1 Sheng-Hui Hung
12 Tung-Wen Ko
3 Pa-Chun
Wang14
1Department of Quality Management Cathay General Hospital Taipei
Taiwan
2Institute of Health Policy and Management National Taiwan Universi-
ty Taipei Taiwan
3Center for Healthcare Quality Management Cheng Hsin General Hos-
pital Taipei Taiwan
4Fu Jen Catholic University School of Medicine New Taipei City Tai-
wan
Corresponding author E-mail address
drtonyseednettw (Pa-Chun Wang)
ABSTRACT Background Appropriate management of adverse medical events (AMEs) is the corner-
stone of patient safety Root cause analysis (RCA) is used to investigate serious or
high-frequency errors but is limited by its inability to explain a broader scope of factors
We re-reviewed RCA cases to understand the underlying human organizational or system-
ic factors affecting AMEs Methods A total of 40 consecutive RCA cases (2012-2016) were
retrieved from the AMEs database A panel was organized to retrospectively re-review these
cases using the Human Factor Analysis and Classification System HFACS Results For
active failures errors stemmed largely from performance-based (95) judgment and deci-
sion-making errors (875) Incorrectly followed procedures (816) and accidental
equipment operation (50) were the most common types of performance-based errors In-
adequate real-time assessment (686) and inappropriate operative actions (686) were
the most common decision-making errors For sources of latent failure teamwork problems
(275) including failure to effectively communicate (818) and communicate critical
information (727) were common Inadequate supervision (929) or command over-
sights (929) were the most common problems related to inadequate supervision (35)
Organizational programpolicy risks not adequately assessed (50) were the most common
problems related to policy and process problem (25) Conclusions The HFACS review
enhances our understanding of human factors underlying AMEs The HFACS reveals latent
supervisory organizational or systematic problems that cannot be addressed through tradi-
tional RCA Keywords patient safety adverse events root cause analysis human factors
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 100
INTRODUCTION Patient safety involves the reduction of patient
harm from potentially avoidable unintended
outcomes [1] Studies have revealed that 50ndash
80 of adverse medical events (AMEs) are pre-
ventable [2-4] to eliminate such errors the ap-
propriate management of AMEs hence repre-
sents the cornerstone of patient safety work
Through incident reporting investigation and
analysis healthcare providers can correct or
re-engineer their care processes to prevent inci-
dent recurrence [25] One of the most popular
tools for investigating AMEs is root cause anal-
ysis (RCA) RCA reconstructs a chain of errors
to identify the deviation of care from normal
processes Nonetheless with a lack of standard-
ized nomenclature and investigation procedures
RCA report conclusions are sometimes too sub-
jective and nonspecific to facilitate any actiona-
ble safety improvement plans [5-7] According
to the UK Health and Safety Executive defini-
tion human factors are environmental organiza-
tional occupational or individual human char-
acteristics which influence behavior at work
such that health and safety are affected [8] Hu-
mans and systems are prone to errors and stud-
ies have showed that nearly 70 of medical
errors involve human factors [2-4] Reasonrsquos
Swiss cheese model described the penetration of
causative human errors through layers of defen-
sive barriers leading to system collapse [9]
With much focus on the temporal sequence and
severity of departure from accepted practices in
an incident the effectiveness of RCA is often
challenged by its incapability of exploring un-
derlying human organization or even systemic
factors [5-7] Reason and others have proposed
that errors can occur at 4 levels 1) unsafe acts
(operator actions) 2) preconditions for unsafe
acts (environmental factors contributing to er-
rors) 3) inadequate supervision (management
actions affecting the operator) and 4) organiza-
tional influences (organizational culture policies
and procedures that affect the operator) [9]
Based on this theory Wiegmann and Shappell
developed the Human Factor Analysis Classifi-
cation System (HFACS) to describe human fac-
tors causing accidents from 4 tiers of categories
Each of these categories consists of nanocodes to
represent specific human behavior or system
problems leading to errors [9-10] The tier for
unsafe acts involves actual provider actions (er-
rors or rule violations) directly leading to events
The tier representing preconditions for unsafe
acts includes operational personnel and envi-
ronmental factors The supervision tier addresses
leadership problems operational planning fail-
ure or correction and supervisory ethics The
tier for organizational influences deals with re-
source management organizational climate and
operational processes (Supplement Table 1) The
HFACS provides standardized investigation
processes for the systematic analysis of common
causes of adverse events across national defense
nuclear power navy aviation and healthcare
industries Taiwan launched its nationwide
AME-reporting system the Taiwan Patient
Safety Reporting System (TPR) in 2004 RCA
methodology was subsequently introduced to the
healthcare industry by the Joint Commission of
Taiwan [11] Since 2012 appropriate manage-
ment of AMEs has been listed as a national pa-
tient safety goal [12] RCA is required by the
Ministry of Health and Welfare for major AMEs
Aside from RCA a comprehensive structural
reliable and valid framework is urgently re-
quired to further guide organizational or even
national patient safety policies In this study we
used the HFACS to review our RCA cases aim-
ing to investigate human factors underlying se-
vere or frequent AMEs
MATERIALS AND METHODS Through continuous sampling 40 consecutive
RCA cases (2012-2016) were retrieved from a
hospitalrsquos (Cathay General Hospital Taipei
Taiwan) AME-reporting system database The
database contains AMEs relating to areas such as
medication patient falls surgery transfusion
clinical care public accidents security hospital
violence tube-related complication unplanned
cardiopulmonary resuscitation laboratory testing
and examination and anesthesia The RCA cases
were sentinel or high-frequency events classified
according to severity assessment category (SAC)
[1113] The SAC is an evaluation method for
categorizing AMEs by severity of effect on pa-
tients health and risk of incident reoccurrence
The HFACS has been modified (from the US
Department of Defense version 70) and trans-
lated into Mandarin Chinese with authorization
from the original developers [10] The Chi-
nese-version HFACS for Taiwan is a valid in-
strument (content validity index 09 Cronbachrsquos
α gt07 interrater reliability Κ 04-10) equiva-
lent to the original English version [9] The
HFACS contains 4 tiers 13 subitems and 109
nanocodes (Supplement Table 1) A panel of 6
reviewers was established All reviewers were
from clinical or management (quality and patient
safety management) backgrounds Reviewers all
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 101
finished human factor education and were
trained to use the HFACS through a consensus
meeting Each RCA case was randomly assigned
to 2 reviewers Human factors leading to partic-
ular AMEs were identified and confirmed when
2 reviewers reached agreement The distribution
of errors among tiers subitems and nanocodes
are provided with descriptive statistics () The
study was approved by the Institutional Review
Board of Cathay General Hospital
(CGH-P105095)
RESULTS AMEs related to laboratory testing and examina-
tion (n = 16) clinical care (n = 9) and medica-
tion (n = 7) were the most commonly observed
in the RCA Most AMEs in this cohort are
ranked as being SAC level 3 (n = 15) or 4 (n =
17) (Table 1)
Acts (Active Failures)
This tier of errors contains 3 subitems and 13
nanocodes In the 40 RCA cases perfor-
mance-based errors for 38 (95) and judgment
and decision-making errors for 35 (875) com-
prised the most common error types with viola-
tion for 6 (15) less common Procedure fol-
lowed incorrectly for 31 out of 38 (816) was
the most common performance-based problem
Inadequate real-time risk management for 24 out
of 35 (686) was the most common judgment
or decision error All of the rule violations were
workaround types for 6 out of 6 (100) (Figure
1)
Preconditions(Latent Failures)
This tier of errors has 9 subitems and 58 nano-
codes In the 40 RCA cases teamwork for 11
(275) and environmental for 8 (20) factors
contributed to most of the errors with mental
and physical state the next most common factor
for 7 (175) Communication for 9 out of 11
(818) and information relay for 8 out of 11
(727) were the most common issues related to
teamwork Few contributors mentioned failures
related to technical errors for 4 (50) or physi-
cal for 1 (125) environment Not paying at-
tention for 4 out of 7 (571) and negative habit
transfer for 4 out of 7 (571) were common
mental contributes noted for 7 (100) Overcon-
fidence was the most common problem related
to emotional status for 4 out of 7 (571) Fa-
tigue was observed in only 2 cases for 2 out of 2
physical problems (100) (Figure 2)
Supervision(Direct Supervisory Chain of
Command)
This tier of errors contains 3 subitems and 17
nanocodes In the 40 RCA cases inadequate
supervision for 14 (35) and inappropriately
planned operations for 11 (275) factors con-
tributed to most of the respective errors fol-
lowed by supervisory violations for 7 (175)
Supervisory or command oversights for 13 out
of 14 (929) were the most common sources of
supervision inadequacy Authorized unnecessary
hazards for 7 out of 11 (636) were the most
common inappropriately planned operations
Failure to enforce rules for 6 out of 7 (857)
was the most common supervisory violation
(Figure 3)
Organization Influence (Upper-Level Man-
agement)
This tier of errors contains 4 subitems and 18
nanocodes In the 40 RCA cases policy and
process issues for 10 (25) and resources prob-
lem for 8 (20) were major concerns Few of
the respective problems are related to climate
and cultural influences for 2 (5) or to person-
nel selection and staffing for 1 (25) Poorly
assessed organizational programs or policy risks
for 5 out of 10 (50) were the most common
policy and process problems Failure to provide
adequate operational information resources for 4
out of 8 (50) and command and control re-
source deficiency for 3 out of 8 (375) were
the main resource management problems Little
was revealed regarding organizational climate
and culture (n = 1 out of 2 50) or staffing for 1
out of 1 (100) (Figure 4)
DISCUSSION Health care is a complex system comprising
many high-reliability organizations (HROs) The
vulnerability of HROs stems from the participa-
tion of multidisciplinary teams in the processes
along a variety of patient care timelines How-
ever humans and systems are inherently prone
to errors the appropriate management of AMEs
is acknowledged to be the cornerstone of patient
safety AMEs should be reported investigated
analyzed and handled appropriately[14] Theo-
retically by analyzing the pattern of key defects
providers can fix errors and re-engineer their
care processes to reduce the possibility of AME
recurrence Taiwan established its nationwide
TPR in 2004 so far 7000 health care facilities
have participated and the database has accumu-
lated more than 055 million AMEs[11] Infor-
mation generated from the TPR database can
improve patient safety at individual organiza-
tional or even national levels However despite
relentless efforts few substantial improvements
have been achieved in patient safety [15-17]
Since its introduction in Taiwan in 2006 the use
of RCA for AMEs has encountered some diffi-
culties 1) No structural and standardized
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 102
framework exists for investigation
cross-institution variability and interrater relia-
bility are often ignored 2) Conclusions are often
subjective and corrective recommendations are
less actionable relying on individual reviewersrsquo
professional backgrounds and their experiences
3) Much focus on event reconstruction and oper-
ator performance means that factors relating to
human behavior organizational culture and
system weakness are not comprehensively ad-
dressed [671718] Traditionally attempts to
improve patient safety in the health care industry
are largely reactive in nature identifying and
correcting errors in care processes [1920]
Causes of defects are not thoroughly understood
Proactive approaches must be taken to address
systematic problems within a complex system
[720] Research suggests that human error is a
causal factor in the occurrence of AMEs AME
investigation targets have moved from skill defi-
ciency toward decision-making attitudes super-
visory factors and even organizational climate
or culture HFACS methodology is based on the
Swiss cheese model that also emphasizes active
and latent failures [921] The study provides
some noteworthy findings First most AMEs as
expected involve active failures such as failure
to follow procedure accidental operation of
equipment inadequate real-time risk manage-
ment and inappropriate action These are all
sharp ends in classic RCA environment physi-
cal and mental factors are less prevalent This
proves that retrospectively determining addi-
tional causal factors is difficult when infor-
mation has not been collected during preliminary
investigation (Figure 1) Second team-
work-related problems particularly in relation to
communication and information relay are well
addressed This may be attributed to the dec-
ade-long institution-wide routine crew resource
management training in the respective research
hospital (Figure 2) Third the HFACS success-
fully reflects the importance of supervisory roles
in the occurrence of AMEs and this cannot be
overlooked (Figure 3) Fourth latent failures
especially in organizational climate or cultural
dimensions have been less frequently addressed
in incident reports a limitation of traditional
RCA However the HFACS review suggests
room for improvement in resource allocation and
policy modification within the hospital The
results of studies can make the organization
think about how to improve the patient safety
and management process from the perspective of
human factors such as improving the comfort of
the working environment and replacing and
equipment resources to prevent personnel from
affecting the medical quality and patient safety
due to the environment or equipment Need to
appropriate assessment of applicability and ade-
quate training of manpower is required The
management and control of risks should be fully
evaluate and grasp resource management and
leaders need to participate in and promote medi-
cal quality and patient safety activities to en-
hance its culture (Figure 4) No panacea exists
to ensure patient safety and improvement targets
originate largely from event investigation find-
ings Unfortunately factors identified from
AMEs are often self-explanatory with little value
for further action correction Reinforcement of
policy or processes redundant education or
repetitious training are formulaic overprescribed
RCA recommendations The use of HFACS in
this study proves that a structural prospective
AME investigation format can potentially help
with proactive patient safety management We
suggest developing an interview guideline for
the routine use of HFACS as a complement to
RCA in every AME investigation This study is a
retrospective study The underlying human fac-
tors can be under-estimated owing to the lack of
related information in the original RCA reports
CONCLUSION The HFACS review in this study enhances our
understanding of human factors in AMEs that
had previously been insufficiently scrutinized
Aside from active process and communication
errors the HFACS enables the prospective in-
vestigation of latent supervisory organizational
or systematic problems that cannot be addressed
through traditional RCA
REFERENCES 1 T Brennan L Leape N Laird et al
Incidence of adverse events and
negligence in hospitalized patients results
of the Harvard Medical Practice Study I N
Engl J Med 1991324370-376
2 Wang CH Shih CL Chen WJ et al
Epidemiology of medical adverse events
perspectives from a single institute in
Taiwan J Formos Med Assoc
2016115434-439
3 Vincent C Simon R Sutcliffe K et al
Errors Conference Executive Summary
Acad Emerg Med 200071180-1182
4 Taitz J Genn K Brooks V et al
System-wide learning from root cause
analysis A report from the New South
Wales Root Cause Analysis Review
Committee Qual Saf Health Care
2010191-5
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 103
5 Hutchinson A Young TA Cooper KL et
al Trends in healthcare incident reporting
and relationship to safety and quality data
in acute hospitals results from the
National Reporting and Learning System
Qual Saf Health Care 2009185-10
6 Mitchell RJ Williamson AM Molesworth
B et al A review of the use of human
factors classification frameworks that
identify causal factors for adverse events
in the hospital setting Ergonomics
2014571443-1472
7 Gurses AP Ozok AA Pronovost PJ Time
to accelerate integration of human factors
and ergonomics in patient safety BMJ
Qual Saf 201221347-351
8 Health and Safety Executive Introduction
to human factors
httpwwwhsegovukhumanfactorsintro
ductionhtm
9 Wiegmann DA Shappell SA A human
error approach to aviation accident
analysis The human factors analysis and
classification system Burlington VT
Ashgate Publishing Ltd 2003
10 Yu-Hsun Cheng Sheng-Hui Hung
Tung-Wen Ko et al An Analysis of the
Reliability and Validity of Human Factors
Analysis Classification System in Medical
Adverse Events Journal of Healthcare
Quality 20191370-76
11 Taiwan Joint Commission on Hospital
Accreditation Taiwan Patient-Safety
Reporting System Annual Report 2017
New Taipei City Taiwan
12 Taiwan Patient Safety Net
httpwwwpatientsafetymohwgovtwCo
ntentzMessagesslistaspxSiteID=1ampMm
mID=621273300317401756
13 Government of Western Australia
Department of Health
httpsww2healthwagovauArticlesS_T
Severity-assessment-codes
14 Farley DO Haviland A Champagne S et
al Adverse-event-reporting practices by
US hospitals results of a national survey
Qual Saf Health Care 200817416-423
15 Shojania KG Thomas EJ Trends in
adverse events over time why are we not
improving BMJ Qual Saf
201322273-277
16 Levitt P Challenging the systems approach
why adverse event rates are not improving
BMJ Qual Saf 2014231051-1052
17 Kellogg KM Hettinger Z Shah M et al
Our current approach to root cause
analysis is it contributing to our failure to
improve patient safety BMJ Qual Saf
201726381-387
18 Khorsandi M Skouras C Beatson K et al
Quality review of an adverse incident
reporting system and root cause analysis of
serious adverse surgical incidents in a
teaching hospital of Scotland Patient Saf
Surg 2012621
19 Diller T Helmrich G Dunning S et al
The Human Factors Analysis
Classification System (HFACS) Applied to
Health Care Am J Med Qual
201429181-190
20 Carayon P Xie A Kianfar S Human
factors and ergonomics as a patient safety
practice BMJ Qual Saf 201423196-205
21 Reason J Human Error New York
Cambridge University Press 1990
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 104
TABLE
Table 1 Incidences by Category (N=40)
CategorySAC SAC 4 SAC 3 SAC 2 SAC 1 total
Laboratory and ex-
amination events
4 10 2 0 16 (400)
Clinical care event 6 2 1 0 9 (225)
Medication event 5 0 2 0 7 (175)
Surgery-related event 1 1 2 0 4 (100)
Transfusion-related
event
1 1 0 0 2 (50)
Tube event 0 1 0 0 1 (25)
Public accident 0 0 1 0 1 (26)
Total 17 (425) 15 (375) 8 (200) 0 40 (100)
SAC 1113 Severity Assessment Code SAC
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 105
FIGURES
Figure 1 Active Failures (N=40)
16 (167)
66 (1000)
640 (150)
235 (57)
735 (200)
2435 (686)
2435 (686)
3540 (875)
438 (105)
438 (105)
738 (184)
1938 (500)
3138 (816)
3840 (950)
0 5 10 15 20 25 30 35 40
Commits WidespreadRoutine Violation
Performs Work-Around Violation
Ignored a CautionWarning
Failure to Prioritize Tasks Adequately
Wrong Choice of Action During an Operation
Inadequate Real‐Time Risk Assessment
Rushed or Delayed a Necessary Action
Breakdown in Visual Scan
Over-ControlledUnder-Controlled AircraftVehicleSystem
Unintended Operation of Equipment
Procedure Not Followed Correctly
Performance-Based Errors
Judgment and Decision Making Errors
Violations
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 106
Figure 2 Preconditions (Latent Failures or Conditions) (N=40)
14 (250)
24 (500)
48 (500)
11 (1000)
18 (125)
840 (200)
0 5 10 15 20 25 30 35 40
Seat and Restraint System Problems
Instrumentation amp Warning System Issues
Noise Interference
Environment
Physical Environment
Technological Environment
27 (286)
27 (286)
27 (286)
37 (129)
47 (511)
47 (571)
77 (1000)
24 (500)
44 (1000)
47 (571)
12 (500)
22 (1000)
27 (286)
740 (175)
0 5 10 15 20 25 30 35 40
Technical or Procedural Knowledge Not Retained After Training
InterferenceInterruption
Task OverUnder Saturation
Distraction
Negative Habit Transfer
Not Paying Attention
Complacency
Overconfidence
Physical IllnessInjury
Fatigue
Physical and Mental State
Physical Problem
State of Mind
Mental Awareness
211 (182)
311 (273)
311 (273)
411 (364)
811 (7227)
911 (818)
1140 (275)
0 5 10 15 20 25 30 35 40
Inadequate Task Delegation
TaskMission PlanningBriefingDebriefing Inadequate
Failure of CrewTeam Leadership
StandardProper Terminology Not Used
Critical Information Not Communicated
Failed to Effectively Communicate
Teamwork
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 107
Figure 3 Supervision (Direct Supervisory Chain of Command) (N=40)
Figure 4 Organization Influence (Upper-Level Management Command Level) (N=40)
114 (71)
114 (71)
214 (143)
314 (214)
1314 (929)
1440 (350)
511 (455)
511 (455)
711 (636)
1140 (275)
47 (571)
67 (857)
740 (175)
0 5 10 15 20 25 30 35 40
Selected Individual with Lack of Proficiency
Improper Role‐modeling
Failed to Provide Proper Training
Failed to IdentifyCorrect Risky or Unsafe Practices
SupervisoryCommand Oversight Inadequate
Performed Inadequate Risk Assessment ‐Formal
Selected Individual with Lack of Current or Limited Experience
Authorized Unnecessary Hazard
Allowing Unwritten Policies to Become Standard
Failure to Enforce Existing Rules
Supervisory Violations
Planned Inappropriate Operations
Inadequate Supervision
12 (500)
12 (500)
240 (50)
110 (100)
510 (500)
1040 (250)
11 (1000)
140 (25)
18 (125)
18 (125)
38 (35)
48 (500)
840 (200)
0 5 10 15 20 25 30 35 40
Organizational Over-confidence or Under-confidence in Equipment
Organizational Culture (attitude actions) Allows for Unsafe TaskMission
Purchasing or Providing Poorly Designed or Unsuitable Equipment
Organizational ProgramPolicy Risks not Adequately Assessed
Failure to Provide Adequate Manning Staffing Resources
Failure to remove inadequate worn-out equipment in timely manner
Inadequate infrastructure
Command and control resources are deficient
Failure to provide adequate operational information resources
Resource Problems
Personnel Selection amp Staffing
Policy and Process Issues
ClimateCulture Influences
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 108
Supplement Table 1- HFACS Content of Human Factor Analysis Classifi-
cation System [9] Tier main level sub-item nano code
Tier 1 Unsafe Acts
Perfor-
mance-Based
Errors
Unintended operation of equipment
Checklist not followed correctly
Procedure not followed correctly
Over-controlledunder-controlled aircraftvehiclesystem
Breakdown in visual scan
Rushed or delayed a necessary action
Judgment amp De-
cision-Making
Errors
Inadequate real‐time risk assessment
Failure to prioritize tasks adequately
Ignored a cautionwarning
Wrong choice of action during an operation
Violations
Performs work-around violation
Commits widespreadroutine violation
Extreme violation-lack of discipline
Tier 2 Preconditions
Environment
Physical environment
Environmental conditions affecting vision
Vibration effects vision or balance
Heatcold stress impairs performance
External force of object impeded an individualrsquos
movement
Lights of other vehiclevesselaircraft affected vision
Noise interference
Technological environment
Seat and restraint system problems
Instrumentation amp warning system issues
Visibility restrictions (not weather related)
Controls and switches are inadequate
Automated system creates unsafe situation
Workspace incompatible with operation
Personal equipment interference
Communication equipment inadequate
Physical and
Mental State
Physical problem
Substance effects (alcohol supplements medications
drugs)
Loss of consciousness (sudden or prolonged onset)
Physical illnessinjury
Fatigue
Inadequate adaptation to darkness
Dehydration
Body sizemovement limitations
Physical strength amp coordination (inappropriate for
task demands)
Nutritiondiet
State of mind
Psychological problem
Life stressors
Emotional state
Personality style
Overconfidence
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 109
Pressing
Complacency
Motivation
Motivational exhaustion (burnout)
Sensory misperception
Motion illusion-kinesthetic
Turning illusionbalance-vestibular
Visual illusion
Misperception of changing environment
Misinterpreted misread instrument
Misinterpretation of auditorysound cues
Spatial disorientation
Temporaltime distortion
Mental awareness
Not paying attention
Fixation
Task overunder saturation
Confusion
Negative habit transfer
Distraction
Geographically lost
Interferenceinterruption
Technical or procedural knowledge not retained after
training
Inaccurate expectation
Teamwork
Failure of crewteam leadership
Inadequate task delegation
Rankposition intimidation
Lack of assertiveness
Critical information not communicated
Standardproper terminology not used
Failed to effectively communicate
Taskmission planningbriefingdebriefing inadequate
Tier 3 Supervision
Supervisory Vio-
lations
Failure to enforce existing rules
Allowing unwritten policies to become standard
Directed individual to violate existing regulations
Authorized unqualified individuals for task
Planned Inappro-
priate Operations
Directed task beyond personnel capabilities
Inappropriate team composition
Selected individual with lack of current or limited experience
Performed inadequate risk assessment ‐formal
Authorized unnecessary hazard
Inadequate Su-
pervision
Supervisorycommand oversight inadequate
Improper role‐modeling
Failed to provide proper training
Failed to provide appropriate policyguidance
Personality conflict with supervisor
Lack of supervisory responses to critical information
Failed to identifycorrect risky or unsafe practices
Selected individual with lack of proficiency
Tier 4 Organizational
Influences
Resource Prob-
lems
Command and control resources are deficient
Inadequate infrastructure
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 110
Failure to remove inadequate worn-out equipment in timely
manner
Failure to provide adequate operational information resources
Fail to provide adequate funding
Personnel Selec-
tion amp Staffing
Personnel recruiting amp selection policies are inadequate
Failure to provide adequate manning staffing resources
Policy amp Process
Issues
Pace of ops-tempoworkload
Organizational programpolicy risks not adequately assessed
Provided inadequate procedural guidance or publications
Organizational (formal) training is inadequate or unavailable
Flawed doctrinephilosophy
Inadequate program management
Purchasing or providing poorly designed or unsuitable equip-
ment
ClimateCulture
Influences
Organizational culture (attitude actions) allows for unsafe
taskmission
Organizational over-confidence or under-confidence in equip-
ment
Unit missionaircraftvehicleequipment change or unit deacti-
vation
Organizational structure is unclear or inadequate
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 111
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
以 HFACS重新檢視根本原因分析案例挖掘造成醫療不良
事件之人為因素
鄭伃洵 1洪聖惠 12柯彤文 3王拔群 14
中文摘要
背景醫療不良事件(AMEs)的管理是促進病人安全的基石根本原因分析
(RCA)是探討重大病人安全不良事件問題但是由於無法解釋更廣泛的因素而受
到限制本研究使用人為因素分類與分析工具(HFACS)回溯審視醫療不良事件
以了解影響醫療不良事件的人為因素及各層面中錯誤原因之分佈或系統性問題
方法本研究回溯 2012-2016年間有做過根本原因分析之醫療不良事件以連續
性取樣方式(continuous sampling)收集 40例醫療不良事件以人為因素分類與分
析工具(HFACS)去系統性的挖掘每件案例發生錯誤之原因結果在行為層面中
分析結果主要為基礎技能錯誤(95)判斷和決策錯誤(875)其中在基礎技能
錯誤當中以未依程序作業執行(816)及未如預期設備操作(50)佔多數判斷和
決策錯誤中以現場風險評估不確實(686)及採取錯的步驟行為(686)佔多數
而在先決條件層面中以團隊合作(275)為主要因素包含溝通不良(818)及重
要訊息未以正確的方式即時傳達(727)佔多數在監督層面當中以監督不周
(929)或監督不妥當(929)為主要因素在組織政策和流程方面(50)以組織
系統的政策風險未充分評估(35)為主要因素結論本研究進一步了解醫療不
良事件在過去使用根本原因分析未探討到的人為因素反映出潛在的監督組織
行為或系統性的問題促進病人安全預防錯誤再發生
關鍵字病人安全醫療不良事件根本原因分析人為因素
1國泰醫療財團法人國泰綜合醫院 品質管理部
2國立臺灣大學健康政策與管理研究所
3振興醫療財團法人振興醫院 醫療品質管理中心
4輔仁大學醫學院
通訊作者王拔群 電子信箱 drtonyseednettw
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin 112
Submitted January 20 2020
Final version accepted April13
2020
Case Report
Juvenile Caruncular Atypical Lymphoid
Proliferation ndash A Rare Case Report
Cite as Hua-Wei Shih Yu-Chi Lin
Juvenile Caruncular Atypical
Lymphoid Proliferation ndash A Rare
Case Report Fu-Jen Journal of
Medicine 3(3) 112-119 2020
DOI
103966181020932020091803003
Hua-Wei Shih1 Yu-Chi Lin
1
1Department of Ophthalmology Shin Kong Wu Ho-Su Memorial Hos-
pital Taipei City Taiwan
Corresponding author E-mail address
yuchi067gmailcom (Yu-Chi Lin)
ABSTRACT
Lesions of the caruncle are very rare Most caruncular lesions are benign though there were still few reported malignant lesions Ocular adnexal lymphoproliferative disease (OALD) one of the differential diagnosis of caruncular lesion is seldom seen in young pa-tient In this article we report a 16-year-old boy with recurrent caruncular atypical lym-phoid proliferation We discuss the epidemiology clinical features images histomorpholo-gy and treatment between ocular adnexal lymphomas (OAL) and reactive lymphoid hyper-plasia (RLH)
Keywords caruncular lesion ocular adnexal lymphoproliferative disease ocular adnexal lymphoma
reactive lymphoid hyperplasia atypical lymphoid proliferation
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
113
INTRODUCTION Lesions of the caruncle are very rare Differen-
tial diagnosis includes nevus myeloproliferative
disorders tumors inflammation infection cysts
vascular lesions and fibrous Biopsy is essential
for diagnosis Levy J et al reported ocular ad-
nexal lymphoproliferative disease (OALD) was
relatively uncommon diagnosis among caruncu-
lar lesions [1]
OALD was seldom described in Asian popula-
tion especially for young age C-Y Cheng re-
ported age-standardized incidence of ocular
adnexal lymphomas (OAL) in Taiwan from 1979
to 1996 was below 07 per million per year and
mean age was 531 years old [2] In 2015 five
Taiwanese cases of OAL whose age ranging
from 45 to 64 were presented [3] However
there were few cases of conjunctival OAL or
RLH in Chinese pediatric patient
Here we present a case of 16-year-old boy with a
caruncular mass at his left eye with recurrence
one month after excision We describe his clini-
cal symptoms photographs pathological results
management and follow-up clinical course in
this report
CASE REPORT A 16-year-old healthy boy presented a mass
lesion at his left eye caruncle accompanied with
the symptom of tearing for one month (Figure 1)
He had no ocular pain no itchiness no blurred
vision no night sweating no fever and no body
weight loss The patient denied systemic diseas-
es and histories of surgery His bilateral best
corrected visual acuity (BCVA) were 66 and
intraocular pressure (IOP) were both within
normal range There were no remarkable find-
ings for his cornea lens fundus and physical
examination Excision was performed and the
mass was soft with fluid inside therefore con-
junctival pyogenic cyst was our initial diagnosis
However one month after the excision a pro-
truding mass recurred at the patientrsquos nasal can-
thus of left eye (Figure 2) There were some
differences compared to previous condition At
the first time the soft mass was contained in a
well-defined cyst wall which more favored py-
ogenic granulation However after short period
of recurrence solid consistency and unclear
margin were found which favored malignancy
Besides the mass partially involved beyond the
gray line of nasal part lower eyelid whereas last
time the cyst mainly extended from conjunctiva
of caruncle The second excisional biopsy was
performed Pathologic examination demonstrat-
ed abundant atypical lymphoid proliferation
(Figure 3A 3B) Immunohistochemical studies
showed that the lymphoid aggregation was
composed predominantly of CD20-positive cells
(Figure 3C) focal positive staining of CD3
(Figure 3D) CD5 CD23 CD10 and negative
staining of cyclin-D1 Unfortunately the cellular
morphology was difficult to be evaluated due to
marked crushing artifact Thus malignant lym-
phoma cannot be excluded totally
Orbital computed tomography (CT) showed a
lesion of soft tissue density at medial canthus of
left orbit without obvious nasolacrimal duct or
bony invasion (Figure 4A) Magnetic resonance
imaging (MRI) with contrast showed strong
enhancement at left medial canthus region (Fig-
ure 4B) There was no remarkable finding in the
systemic workup including complete blood
count and differential count biochemical pro-
files and 18F-fluoro-2-deoxyglucose positron
emission tomographycomputed tomography
(18F-FDG PETCT) indicating no evidence of
systemic involvement
After the second excision we preferred con-
servative management for him due to the uncer-
tainty of malignancy and to avoid side effects
from aggressive treatment No sign of recurrence
was noted after 10 months of observation The
follow-up photo was taken at three months after
the second operation (Figure 5)
DISCUSSION Ocular adnexal lymphoproliferative disease
(OALD) consists of the spectrum of lymphoid
disease affecting the tissues surrounding the eye
including ocular adnexal lymphomas (OAL) and
lymphoid hyperplasia (LH) [4] The conjunctiva
is an important location for extranodal lympho-
ma development which comprises 25 of OAL
[5]
OAL can be grouped into two categories based
on their appearance of cells under the micro-
scope low-grade and high-grade [6] Extranodal
marginal zone lymphoma of mucosa-associated
lymphoid tissue (EMZLMALT) is the most
common subtype of OAL followed by follicular
lymphoma [7-9] Both of the above are
low-grade lymphomas
LH can be further divided by histopathology into
reactive lymphoid hyperplasia (RLH) and atypi-
cal lymphoid hyperplasia (ALH) RLH has to-
tally benign morphology and immunophenotype
whereas ALH has borderline lesions between
RLH and lymphoma [10] OAL and LH are
mostly seen in patients with age between 50-70
years old There are rare cases in pediatric group
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
114
[71011] In the C-Y Chengrsquos statistical report of
OAL in Taiwan only 8 patients were younger
than 15 years old among the 101 cases of ocular
lymphoma [2] According to an US study inci-
dence rates of OAL were analyzed in different
age groups the group of age over 50 had the
highest incidence rate of 574 per million per-
son-years while the 0-19 age group had the
lowest incidence rate of 009 per million per-
son-years [12] The incidence of LH was even
less than OAL [13]
Patients with OALD may be asymptomatic or
with symptoms of proptosis eyelid swelling a
palpable painless mass or conjunctival salmon
patch Diplopia visual loss pain or inflamma-
tion occurred less frequently implying more
aggressive features [714]
Orbital LH is not distinguishable from low-grade
lymphoma radiologically They both typically
present a round or lobulated mass that diffusely
moderately enhances with contrast and usually
shows homogenous hypointense or isointense to
muscle barely invasion to bone or nervous sys-
tem [10] Atypical appearances including inho-
mogeneous calcification or bony changes may
be seen in high-grade lymphoma case reports
such as ocular adnexal diffuse large B-cell lym-
phoma (DLBCL) which is one of the more ag-
gressive type of OAL [7] Whole body PET is
used for not only the evaluation of systemic
involvement but also the standard for staging
lymphoma Our patientrsquos image studies revealed
neither obvious local invasion nor systemic ma-
lignancy indicating high-grade lymphoma was
less likely Low-grade lymphoma and benign
reactive lymphoid hyperplasia were still under
consideration
Histomorphology analysis and immunohisto-
chemistry (IHC) are essential for diagnosis
Flow cytometry and polymerase chain reaction
(PCR) technique are also applied to help differ-
entiate from RLH and OAL [1016] Our case
had immunohistochemical profile of positivity
for CD20 predominantly positivity focally for
CD3 CD5 CD10 CD23 and negativity for cy-
clin-D1 BCL-6 staining was not performed in
our casersquos biopsy Thus according to the IHC
report RLH ALH and follicular lymphoma are
probable diagnosis of our patient
Radiation therapy is the standard treatment for
low-grade OAL that is classified as T1N0M0 or
T2N0M0 according to the AJCC criteria [15]
İncesoy-Ouml zdemir S et al reported a 10-year-old
boy diagnosed of MALT lymphoma who was
treated with local radiotherapy (36 Gy) and
there were no local or systemic recurrences dur-
ing his nearly four-year follow-up [17] Another
case report represented a 21-year-old man of
conjunctival follicular lymphoma treated with
surgical excision only showing no evidence of
recurrence after 8 months follow-up [18] Other
treatment options for pediatric and juvenile OAL
were performed in some case reports including
intravenous rituximab intralesional interfer-
on-α-2b topical interferon a6 systemic doxycy-
cline surgical excision and postoperative local
cryotherapy [15]
Treatment for young conjunctival RLH was less
discussed in the past In a case series article
three children (9 13 14 years old respectively)
of RLH received surgical resection without fur-
ther postoperative management and no signs of
recurrence were noted during follow-up [19]
Short-term topical and oral corticosteroids after
surgical excision were prescribed in two pediat-
ric RLH patients for their small residual mass
However poor response in both cases was nota-
ble [20]
Our patient declined to receive radiotherapy or
any further postoperative treatment mainly due
to his concerning of possible side effects (such
as dry eye and cataract)
CONCLUSION We present a rare case of caruncle mass in this
report OALD is one of the relatively uncommon
diagnosis among caruncular lesions OALD
includes benign RLH and malignant OAL
which are both mainly seen in elderly patients
even rarer in pediatric or juvenile group
The standard treatment for low-grade OAL and
RLH in young patents are still debatable How-
ever long-term follow-up is suggested for both
OAL and RLH patients Though RLH has a be-
nign and self-limited course risk of malignant
transformation is possible
REFERENCES 1 Levy J Ilsar M Deckel Y et al Lesions of
the caruncle a description of 42 cases and
a review of the literature Eye
200923(5)1004-1018
2 C-Y Cheng and W-M Hsu Incidence of
eye cancer in Taiwan an 18-year review
Eye 200418152-158
3 Chui-Lien Tsen Muh-Chiou Lin
Youn-Shen Bee et al Ocular adnexal
lymphoma Five case reports and a
literature review Taiwan Journal of
Ophthalmology 20155(2)99-102
4 Liesegang TJ Ocular adnexal
lymphoproliferative lesions Mayo Clin
Proc 199368(10)1003-1010
5 Kirkegaard MM Coupland SE Prause JU
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
115
et al Malignant lymphoma of the
conjunctiva Surv Ophthalmol
201560(5)444-458
6 Stacy RC Jakobiec FA Schoenfield L et
al Unifocal and multifocal reactive
lymphoid hyperplasia vs follicular
lymphoma of the ocular adnexa Am J
Ophthalmol 2010150(3)412-426
7 Sullivan TJ Ocular Adnexal
Lymphoproliferative Disease In Guthoff
RF Katowitz JA eds Oculoplastics and
Orbit Berlin Heidelberg Springer
20101-19
8 White Valerie A Understanding and
Classification of Ocular Lymphomas
Ocular Oncology and Pathology
20195379-386
9 Stefanovic A Lossos IS Extranodal
marginal zone lymphoma of the ocular
adnexa Blood 2009114(3)501-510
10 Andrew NH Coupland SE Pirbhai A et al
Lymphoid hyperplasia of the orbit and
ocular adnexa A clinical pathologic review
Surv Ophthalmol 201661(6)778-790
11 Ferry JA1 Fung CY Zukerberg L et al
Lymphoma of the ocular adnexa A study
of 353 cases Am J Surg Pathol
200731(2)170-184
12 WM Hassan MS Bakry HM Hassan et al
Incidence of orbital conjunctival and
lacrimal gland malignant tumors in USA
from Surveillance Epidemiology and End
Results 1973-2009 Int J Ophthalmol
20169(12)1808-1813
13 Ajay A Rao John H Naheedy James Y-Y
Chen et al A Clinical Update and
Radiologic Review of Pediatric Orbital
and Ocular Tumors Journal of Oncology
2013(9)975908
14 Sullivan TJ Whitehead K Williamson R
et al Lymphoproliferative disease of the
ocular adnexa a clinical and pathologic
study with statistical analysis of 69
patients Ophthal Plast Reconstr Surg
200521177-188
15 Tanenbaum RE Galor A Dubovy SR et al
Classification diagnosis and management
of conjunctival lymphoma Eye Vis (Lond)
2019622
16 Olga Klavdianou Georgios Kondylis
Vasileios Georgopoulos et al Bilateral
benign reactive lymphoid hyperplasia of
the conjunctiva a case treated with oral
doxycycline and review of the literature
Eye Vis (Lond) 2019626
17 İncesoy-Ouml zdemir S Yuumlksek N Bozkurt C
et al A rare type of cancer in children
extranodal marginal zone B-cell (MALT)
lymphoma of the ocular adnexa Turk J
Pediatr 201456(3)295-298
18 Lynn J Poole Perry Frederick A Jakobiec
Peter A D Rubin Conjunctival Pediatric
Follicular Lymphoma Arch Ophthalmol
2012130(7)941-943
19 Abdullah Al-Mujaini Upender Wali
Anuradha Ganesh1 et al Ocular Adnexal
Reactive Lymphoid Hyperplasia in
Children Middle East Afr J Ophthalmol
201219(4)406-409
20 McLeod SD Edward DP Benign
lymphoid hyperplasia of the conjunctiva in
children Arch Ophthalmol
1999117(6)832-835
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
116
FIGURES
Figure 1 Slit lamp image of a mass lesion at the patientrsquos left eye caruncle for one month
Figure 2 One month after the first excision a protruding mass recurred at the patientrsquos nasal canthus
of left eye It partially involved beyond the gray line of nasal part lower eyelid
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
117
Figure 3 Histomorphology analysis and immunohistochemistry study of the caruncular lesion Abun-
dant atypical lymphoid proliferation presented in low-power photomicrograph (A) and
high-power photomicrograph (B) under hematoxylin-eosin staining The lymphoid aggrega-
tion was composed predominantly of CD20-positive cells (C) and focal positive staining of
CD3 (D)
Figure 4 Non-contrast orbital computed tomography showed a lesion of soft tissue density at medial
canthus of left orbit without obvious nasolacrimal duct or bony invasion (A) Magnetic reso-
nance imaging with contrast showed strong enhancement at left medial canthus region (B)
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
118
Figure 5 The follow-up photo were taken at three months after the second excision showing no signs
of recurrence
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
119
Juvenile Caruncular Atypical Lymphoid Proliferation ndash A Rare Case Report
罕見病例報告mdash青少年之淚阜非典型淋巴增生
施驊瑋 1林友祺 1
中文摘要
淚阜病灶相當罕見大部分為良性病灶眼睛及附屬結構淋巴增生疾病為其
鑑別診斷之一非常少見於年輕人或兒童我們報告一位 16歲的健康男性因
左眼淚阜無痛性腫塊接受切除手術卻於術後一個月復發執行第二次切除手術
後門診追蹤十個月未再復發此案例表現了部分良性與部分惡性腫瘤的特徵
我們針對反應性淋巴增生眼睛及附屬結構淋巴癌兩個疾病做討論及文獻回顧
關鍵字淚阜病灶眼睛及附屬結構淋巴增生疾病眼睛及附屬結構淋巴癌反
應性淋巴增生非典型淋巴增生
1 新光吳火獅紀念醫院眼科
通訊作者林友祺 電子信箱 yuchi067gmailcom
Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh 120
Submitted March 26 2020
Final version accepted April 16
2020
Case Report
Hyperacute intramembranous hemor-
rhage after burr hole craniostomy for
chronic subdural hematoma
Cite as Meng-Chi Lin Jui-Ming
Sun Yu-Hao Chen Cheng-Ta
Hsieh
Hyperacute intramembranous
hemorrhage after burr hole crani-
ostomy for chronic subdural he-
matoma Fu-Jen Journal of Medi-
cine 3(4) 120-125 2020
DOI
103966181020932020091803004
Meng-Chi Lin1 Jui-Ming Sun23 Yu-Hao Chen24 Cheng-Ta
Hsieh567
1Department of Surgery Zuoying Branch Kaohsiung Armed Forces
General Hospital Kaohsiung 813 Taiwan 2Section of Neurosurgery Department of Surgery Chia-Yi Christian
Hospital Chia-Yi City 600 Taiwan 3Department of Biotechnology Asia University Taichung City 41354
Taiwan 4Chung-Jen Junior College of Nursing Health Sciences and Manage-
ment Chia-Yi Country 62241 Taiwan 5Division of Neurosurgery Department of Surgery Sijhih Cathay Gen-
eral Hospital New Taipei City 22174 Taiwan 6Department of Medicine School of Medicine Fu Jen Catholic Univer-
sity New Taipei City 24205 Taiwan 7Department of Neurological Surgery Tri-Service General Hospital
National Defense Medical Center Taipei 114 Taiwan
Corresponding author E-mail address
nogormail2000comtw (Cheng-Ta Hsieh)
ABSTRACT
Burr hole craniostomy with closed-system drainage is an effective and common neurosurgical procedure to manage chronic subdural hematoma Postoperative hem-orrhage a well-known but infrequent complication may result in increased neurolog-ical deficits However hyperacute intramembranous hemorrhage within the inner and outer membrane of hematoma after burr hole craniostomy with irrigation and closed-system drainage has not been described previously Herein we report a case of postoperative spontaneous hyperacute intramembranous hemorrhage after burr hole craniostomy with closed-system drainage to manage a chronic subdural hematoma we subsequently discuss the possible pathophysiological mechanisms and review the relevant literature
Keywords Chronic subdural hematoma acute subdural hematoma bleeding burr hole craniostomy
drainage
Fu-J
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of Medicine V
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Vol 3 No 4 2
Acute intram
Yu-Hao Chen
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outer and ievidence suggwith or wite and widely ut and that it ] Recurrence r this surgerywever the hyng after burr ely been discucase of a pa
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ISCUSSIO61-year-old won without regd been takingning Ganodermrs She was tment when shurological exasgow Coma S
muscle strengs was 45 on
ale Her laborh the normal rnoted Brain
n revealed Ch a marked m
ently she receniostomy withinage ring surgery mthe subdural sn of the duramatoma The arile saline throsed drainage swever this inm the subduraealed a hyperdural space fniostomy siteniotomy withthe hematom
morrhage was d inner membgure 3) No aface was obseealed an organn of fibroblasne Postoperaogical deficits
EFERENCRohde VComplicatiand closedsubdural analysis of
active bleedinerved Histolonized hematots and capilla
ative recoverywas gradual a
ON oman had a hi
gular medicatig nutritional ma lucidum referred to ohe became proxamination rScale ratings wgth score in th
the Medical ratory examinranges with nn computed
CSDH in the midline shift (ived one righth irrigation a
motor oilndashlikespace was uncal and outer marea was irrigaough the subdusystem was plcreased the rel space An emracute hemorrfrom the frone (Figure 2B
membranectma was perfo
only observebrane of theactive bleedinerved Histolonized hematots and capilla
ative recoverywas gradual a
CES V Graf Gons of burr-
d-system draihematomas
f 376 patient
ng from the ogical examinoma with prolaries in the m
y of previous and favorable
history of hypeion treatmentsupplements for more tha
our emergencyogressively drrevealed thatwere E1M5V2he left side ex
Research Conation results no bleeding ditomography right hemisp
(Figure 1) St parietal burrand closed-sy
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dural catheter laced (Figureedness of the mergency brairrhage in the ntal region to
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y of previous and favorable
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of Medicine V
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Vol 3 No 4 2
Acute intram
Yu-Hao Chen
vealing a layer
displaying a m
quent CT scan
em drainage (
rhage in the ri
2020
membranous
Cheng-Ta Hs
red type of CS
midline shift
ns (A) Bone w
(white arrow)
ight frontal re
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ieh
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and (B) Soft
gion (white ar
rrow) in the rig
showed the b
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123
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Fu-J
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g-Chi Lin Ju
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Vol 3 No 4 2
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Yu-Hao Chen
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Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh
125
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
慢性硬腦膜下出血進行鑽顱引流手術造成超急性夾膜內出
血
林孟楫 1孫瑞明 23陳昱豪 24謝政達 567
中文摘要
鑽顱併封閉系統引流手術是治療慢性硬腦膜下出血患者一種有效且常見的
神經外科手術方式術後出血可能導致神經功能缺損惡化是眾所周知但不常見
的併發症之一然而至今仍未有鑽孔併封閉系統引流造成原本慢性硬腦膜血
塊內膜和外膜間急性夾膜間出血案例在這裡我們報告一例慢性硬腦膜下出
血病患者接受鑽顱併封閉系統引流手術治療造成術後急性夾膜間出血我們在
本文中討論可能的致病機制並回顧相關文獻
關鍵字慢性硬腦膜下出血急性硬腦膜下出血出血鑽顱術引流
1國軍高雄總醫院左營分院 外科部
2崇仁醫護管理專科學校
3亞洲大學 生物科技學系
4戴德森醫療財團法人嘉義基督教醫院 外科部 神經外科
5汐止國泰綜合醫院 神經外科
6輔仁大學 醫學系
7 國防醫學院 三軍總醫院 神經外科
通訊作者謝政達 電子信箱 nogormail2000comtw
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
126
Submitted January 21 2020
Final version accepted July 08
2020
Case Report
Hamartoma of the breast A case report
Cite as Hsuan-An Chen
Cheng-Yu Lo Shih-Hung Huang
Chin-Lung Lin
Hamartoma of the breast A case
report Fu-Jen Journal of Medicine
3(5) 126-130 2020
DOI
103966181020932020091803005
Hsuan-An Chen1 Cheng-Yu Lo
3 Shih-Hung Huang
3 Chin-Lung
Lin2
1Department of Surgery Cathay General Hospital Taipei Taiwan
2Department of General Surgery Cathay General Hospital Taipei Tai-
wan
3Department of Pathology Cathay General Hospital Taipei Taiwan
Corresponding author E-mail address
lungyungmailcom (Chin-Lung Lin)
ABSTRACT
Breast hamartoma is an uncommon benign tumor rarely associated with malignancy An
excision and histological examination is necessary for the differential diagnosis We report
a case of a 49-year-old female patient presenting with a lump in the right breast Ultrasound
examination which demonstrated a 4411 cm hypoechoic lesion with lipoma Partial mas-
tectomy was arranged and the diagnosis of a hamartoma was confirmed by the histological
examination
Keywords Breast tumor Hamartoma Ultrasound
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
127
INTRODUCTION The hamartoma is a benign tumor-like lesion
that can affect various organs of the body in-
cluding lungs kidneys skin and more rarely the
breast In 1981 the hamartomas were recognized
in the WHO classification[1] They are defined
as well-demarcated mass of mammary ducts and
lobules containing varying amounts of fibrous
and adipose tissue and producing a distinctive
mammographic image
CASE REPORT A 49 year-old female had past history of left
breast mastitis with abscess status post partial
mastectomy This time she presented to our out
patient clinic for breast examination Physical
examination revealed a painless palpable mova-
ble and painless lump at upper outer quadrant of
right breast The risk of breast cancer was not
noted and the patient did not have any family
history of breast cancer The patient also denied
any trauma history before Ultrasound examina-
tion was arranged which demonstrated a 4411
cm hypoechoic lesion with lipoma at 3 oclock 2
cm from nipple of right breast and multiple hy-
poechoic nodules of various size in both breasts
and there was no suspicious axillary lymph
nodes noted (Figure1) Surgical treatment was
arranged partial mastectomy of right breast
harmartoma was successfully performed A 32 x
31 x 21 cm tumor was completely excised
Grossly examination showed a gray to yellow
and firm to fatty The diagnosis of a hamartoma
was confirmed by the histological examination
Microscopically sections of the breast lesion
show mammary hamartoma composed of ducts
lobules with interlobular fibrous tissue and adi-
pose tissue Fibrocystic change apocrine meta-
plastic ducts and scattered foci of adenosis are
noted The overall lobulocentric architecture and
the 2-cell pattern of the epithelium are preserved
columnar cell change and focal microcalcifica-
tion are present (Figure2) Based on submitted
biopsy specimen in-situ or invasive tumor cells
are not identified
DISCUSSION Hamartoma of the breast is a benign tumor like
nodule it was also known as fibroadenolipoma
lipofibroadenoma or adenolipoma based on its
predominant components It was composed of
varying amounts of glandular adipose and fi-
brous tissue[2] Hamartomas were first described
in 1971 by Arrigoni et al in a study of 10 patients
which breast tumors clinically and grossly re-
sembled fibroadenomas[3]
A higher predominance of tumors exists in fe-
males compared with males Hamartomas are
slowly-growing lesions with the diameter rang-
ing from 2 cm to 5 cm sometimes hamartomas
can reach giant diameter [4]
The clinical diagnosis of hamartoma is based on
the findings from mammography sonography
and histology examinations The hamartomas are
usually incidentally diagnosed by the women
older than 40 year-old starting mammography
screening
On physicial examination harmatomas are usu-
ally occult painless they may be as large mo-
bile soft to firm masses[5] Ultrasound showed
well capsulated mass with echogenic rim and
internal heterogeneity Mammography exam
showed well-circumscribed round to oval
masses containing fat and soft tissue densities
with a thin radiopaque pseudocapsule The
pseudocapsule results from displacement of
breast parenchyma by the tumor [56] In Pa-
thology finding microglandular adenosis is pre-
sent in fibroadipose stroma surrounded by a thin
fibrous capsule It composed of a combination of
epithelial and stromal elements usually with
normal ducts or lobules although variations of
normal tissue may also be seen Fibroadenoli-
poma myoid hamartoma and chondrolipoma are
histological variations of hamartomas depend-
ing on the proportion of normal breast tissue
elements[7]
Malignancy associated with hamartomas are
very rare[8] However it has been reported
hamartomas develop into carcinoma Malignant
transformation can occur as a result of cellular
atypia in the epithelial component of the mass[9]
Surgical removal is the curative method for
breast hamartomas[10] Diagnostic material such
as mammography ultrasonography or core nee-
dle biopsy may not give the definitive diagnosis
Therefore surgical excision and histological
examination is necessary for differential diagno-
sis[111213]
Although it is rare hamartoma can be seen along
with malignancy as it is formed from similar
components of breast tissue Therefore careful
diagnosis and appropriate management including
surgery are required
REFERENCES 1 World Health Organization (1981)
Histological typing of breast tumors In
International histological classification of
tumors 1981 2nd ed
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
128
2 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11435ndash449
2006
3 ArrigoniMG DockertyMB JuddES
The identificationand treatment of
mammary hamartoma Surg Gynecol
Obstet1971 133 577-82
4 Sanal HT Ersoz N Altinel O Unal E Can
C Giant hamartoma of the breast Breast J
2006 12 84-85
5 Feder JM de Paredes ES Hogge JP
Wilken JJ Unusual breast lesions
radiologic-pathologic correlation
Radiographics 1999 19S11ndashS26
6 Murat A Ozdemir H Yildirim H Poyraz
AK Ozercan R Hamartoma of the breast
Australas Radiol 200751 Spec NoB37ndash
9
7 Fisher CJ Hanby AM Robinson L Millis
RR Mammary hamartoma-a review of 35
cases Histopathology 1992 20 99-106
8 Choi N Ko ES Invasive ductal carcinoma
in a mammary hamartoma case report and
review of the literature Korean J Radiol
2010 Nov-Dec11(6)687-91
9 Lee EH Wylie EJ Bourke AG Bastiaan
De Boer W Invasive ductal carcinoma
arising in a breast hamartoma two case
reports and a review of the literature Clin
Radiol 2003 58 80-3
10 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11 435 ‑449
2006
11 Coyne J Hobbs FM Boggis C Harland R
Lobular carcinoma in a mammary
hamartoma J Clin Pathol 199245936ndash
937
12 G M K Tse B K B Law T K F Ma A B W
Chan Hamartoma of the breast a
clinicopathological review J Clin Pathol
200255951ndash954
13 RAAmir SSheikh BreasthamartomaA
report of 14cases of an under-recognized
and under-reported entity International
Journal of Surgery Case Reports
22(2016)1ndash4
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
129
FIGURES
Figure 1 Ultrasound shows a 4411 cm hypoechoic lesion with lipoma at 3 oclock 2 cm from nipple
of right breast
Figure 2 Photomicrograph shows mammary hamartoma composed of ducts lobules with interlobular
fibrous tissue and adipose tissue
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
130
Hamartoma of the breast A case report
乳房錯構瘤罕見個案報告
陳宣安 1羅承裕 3黃世鴻 3林錦龍 2
中文摘要
乳房錯構瘤是一種罕見之乳房良性腫瘤切除手術及病理化驗來做鑑別診斷
我們報告一位 49歲女性以可觸摸到無痛性右側乳房腫塊為臨床表徵超音波
看到一個邊緣清楚低迴音的腫塊病患接受手術切除病灶病理診斷證實為乳
房錯構瘤
關鍵字乳房腫瘤錯構瘤超音波攝影
1國泰綜合醫院外科部
2國泰綜合醫院一般外科
3國泰綜合醫院病理科
通訊作者林錦龍 電子信箱 lungyungmailcom
Fu-Jen Journal of Medicine
Mission and Goals
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aims to enhance research quality of staffs in the College of Medicine Fu Jen
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Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 100
INTRODUCTION Patient safety involves the reduction of patient
harm from potentially avoidable unintended
outcomes [1] Studies have revealed that 50ndash
80 of adverse medical events (AMEs) are pre-
ventable [2-4] to eliminate such errors the ap-
propriate management of AMEs hence repre-
sents the cornerstone of patient safety work
Through incident reporting investigation and
analysis healthcare providers can correct or
re-engineer their care processes to prevent inci-
dent recurrence [25] One of the most popular
tools for investigating AMEs is root cause anal-
ysis (RCA) RCA reconstructs a chain of errors
to identify the deviation of care from normal
processes Nonetheless with a lack of standard-
ized nomenclature and investigation procedures
RCA report conclusions are sometimes too sub-
jective and nonspecific to facilitate any actiona-
ble safety improvement plans [5-7] According
to the UK Health and Safety Executive defini-
tion human factors are environmental organiza-
tional occupational or individual human char-
acteristics which influence behavior at work
such that health and safety are affected [8] Hu-
mans and systems are prone to errors and stud-
ies have showed that nearly 70 of medical
errors involve human factors [2-4] Reasonrsquos
Swiss cheese model described the penetration of
causative human errors through layers of defen-
sive barriers leading to system collapse [9]
With much focus on the temporal sequence and
severity of departure from accepted practices in
an incident the effectiveness of RCA is often
challenged by its incapability of exploring un-
derlying human organization or even systemic
factors [5-7] Reason and others have proposed
that errors can occur at 4 levels 1) unsafe acts
(operator actions) 2) preconditions for unsafe
acts (environmental factors contributing to er-
rors) 3) inadequate supervision (management
actions affecting the operator) and 4) organiza-
tional influences (organizational culture policies
and procedures that affect the operator) [9]
Based on this theory Wiegmann and Shappell
developed the Human Factor Analysis Classifi-
cation System (HFACS) to describe human fac-
tors causing accidents from 4 tiers of categories
Each of these categories consists of nanocodes to
represent specific human behavior or system
problems leading to errors [9-10] The tier for
unsafe acts involves actual provider actions (er-
rors or rule violations) directly leading to events
The tier representing preconditions for unsafe
acts includes operational personnel and envi-
ronmental factors The supervision tier addresses
leadership problems operational planning fail-
ure or correction and supervisory ethics The
tier for organizational influences deals with re-
source management organizational climate and
operational processes (Supplement Table 1) The
HFACS provides standardized investigation
processes for the systematic analysis of common
causes of adverse events across national defense
nuclear power navy aviation and healthcare
industries Taiwan launched its nationwide
AME-reporting system the Taiwan Patient
Safety Reporting System (TPR) in 2004 RCA
methodology was subsequently introduced to the
healthcare industry by the Joint Commission of
Taiwan [11] Since 2012 appropriate manage-
ment of AMEs has been listed as a national pa-
tient safety goal [12] RCA is required by the
Ministry of Health and Welfare for major AMEs
Aside from RCA a comprehensive structural
reliable and valid framework is urgently re-
quired to further guide organizational or even
national patient safety policies In this study we
used the HFACS to review our RCA cases aim-
ing to investigate human factors underlying se-
vere or frequent AMEs
MATERIALS AND METHODS Through continuous sampling 40 consecutive
RCA cases (2012-2016) were retrieved from a
hospitalrsquos (Cathay General Hospital Taipei
Taiwan) AME-reporting system database The
database contains AMEs relating to areas such as
medication patient falls surgery transfusion
clinical care public accidents security hospital
violence tube-related complication unplanned
cardiopulmonary resuscitation laboratory testing
and examination and anesthesia The RCA cases
were sentinel or high-frequency events classified
according to severity assessment category (SAC)
[1113] The SAC is an evaluation method for
categorizing AMEs by severity of effect on pa-
tients health and risk of incident reoccurrence
The HFACS has been modified (from the US
Department of Defense version 70) and trans-
lated into Mandarin Chinese with authorization
from the original developers [10] The Chi-
nese-version HFACS for Taiwan is a valid in-
strument (content validity index 09 Cronbachrsquos
α gt07 interrater reliability Κ 04-10) equiva-
lent to the original English version [9] The
HFACS contains 4 tiers 13 subitems and 109
nanocodes (Supplement Table 1) A panel of 6
reviewers was established All reviewers were
from clinical or management (quality and patient
safety management) backgrounds Reviewers all
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 101
finished human factor education and were
trained to use the HFACS through a consensus
meeting Each RCA case was randomly assigned
to 2 reviewers Human factors leading to partic-
ular AMEs were identified and confirmed when
2 reviewers reached agreement The distribution
of errors among tiers subitems and nanocodes
are provided with descriptive statistics () The
study was approved by the Institutional Review
Board of Cathay General Hospital
(CGH-P105095)
RESULTS AMEs related to laboratory testing and examina-
tion (n = 16) clinical care (n = 9) and medica-
tion (n = 7) were the most commonly observed
in the RCA Most AMEs in this cohort are
ranked as being SAC level 3 (n = 15) or 4 (n =
17) (Table 1)
Acts (Active Failures)
This tier of errors contains 3 subitems and 13
nanocodes In the 40 RCA cases perfor-
mance-based errors for 38 (95) and judgment
and decision-making errors for 35 (875) com-
prised the most common error types with viola-
tion for 6 (15) less common Procedure fol-
lowed incorrectly for 31 out of 38 (816) was
the most common performance-based problem
Inadequate real-time risk management for 24 out
of 35 (686) was the most common judgment
or decision error All of the rule violations were
workaround types for 6 out of 6 (100) (Figure
1)
Preconditions(Latent Failures)
This tier of errors has 9 subitems and 58 nano-
codes In the 40 RCA cases teamwork for 11
(275) and environmental for 8 (20) factors
contributed to most of the errors with mental
and physical state the next most common factor
for 7 (175) Communication for 9 out of 11
(818) and information relay for 8 out of 11
(727) were the most common issues related to
teamwork Few contributors mentioned failures
related to technical errors for 4 (50) or physi-
cal for 1 (125) environment Not paying at-
tention for 4 out of 7 (571) and negative habit
transfer for 4 out of 7 (571) were common
mental contributes noted for 7 (100) Overcon-
fidence was the most common problem related
to emotional status for 4 out of 7 (571) Fa-
tigue was observed in only 2 cases for 2 out of 2
physical problems (100) (Figure 2)
Supervision(Direct Supervisory Chain of
Command)
This tier of errors contains 3 subitems and 17
nanocodes In the 40 RCA cases inadequate
supervision for 14 (35) and inappropriately
planned operations for 11 (275) factors con-
tributed to most of the respective errors fol-
lowed by supervisory violations for 7 (175)
Supervisory or command oversights for 13 out
of 14 (929) were the most common sources of
supervision inadequacy Authorized unnecessary
hazards for 7 out of 11 (636) were the most
common inappropriately planned operations
Failure to enforce rules for 6 out of 7 (857)
was the most common supervisory violation
(Figure 3)
Organization Influence (Upper-Level Man-
agement)
This tier of errors contains 4 subitems and 18
nanocodes In the 40 RCA cases policy and
process issues for 10 (25) and resources prob-
lem for 8 (20) were major concerns Few of
the respective problems are related to climate
and cultural influences for 2 (5) or to person-
nel selection and staffing for 1 (25) Poorly
assessed organizational programs or policy risks
for 5 out of 10 (50) were the most common
policy and process problems Failure to provide
adequate operational information resources for 4
out of 8 (50) and command and control re-
source deficiency for 3 out of 8 (375) were
the main resource management problems Little
was revealed regarding organizational climate
and culture (n = 1 out of 2 50) or staffing for 1
out of 1 (100) (Figure 4)
DISCUSSION Health care is a complex system comprising
many high-reliability organizations (HROs) The
vulnerability of HROs stems from the participa-
tion of multidisciplinary teams in the processes
along a variety of patient care timelines How-
ever humans and systems are inherently prone
to errors the appropriate management of AMEs
is acknowledged to be the cornerstone of patient
safety AMEs should be reported investigated
analyzed and handled appropriately[14] Theo-
retically by analyzing the pattern of key defects
providers can fix errors and re-engineer their
care processes to reduce the possibility of AME
recurrence Taiwan established its nationwide
TPR in 2004 so far 7000 health care facilities
have participated and the database has accumu-
lated more than 055 million AMEs[11] Infor-
mation generated from the TPR database can
improve patient safety at individual organiza-
tional or even national levels However despite
relentless efforts few substantial improvements
have been achieved in patient safety [15-17]
Since its introduction in Taiwan in 2006 the use
of RCA for AMEs has encountered some diffi-
culties 1) No structural and standardized
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 102
framework exists for investigation
cross-institution variability and interrater relia-
bility are often ignored 2) Conclusions are often
subjective and corrective recommendations are
less actionable relying on individual reviewersrsquo
professional backgrounds and their experiences
3) Much focus on event reconstruction and oper-
ator performance means that factors relating to
human behavior organizational culture and
system weakness are not comprehensively ad-
dressed [671718] Traditionally attempts to
improve patient safety in the health care industry
are largely reactive in nature identifying and
correcting errors in care processes [1920]
Causes of defects are not thoroughly understood
Proactive approaches must be taken to address
systematic problems within a complex system
[720] Research suggests that human error is a
causal factor in the occurrence of AMEs AME
investigation targets have moved from skill defi-
ciency toward decision-making attitudes super-
visory factors and even organizational climate
or culture HFACS methodology is based on the
Swiss cheese model that also emphasizes active
and latent failures [921] The study provides
some noteworthy findings First most AMEs as
expected involve active failures such as failure
to follow procedure accidental operation of
equipment inadequate real-time risk manage-
ment and inappropriate action These are all
sharp ends in classic RCA environment physi-
cal and mental factors are less prevalent This
proves that retrospectively determining addi-
tional causal factors is difficult when infor-
mation has not been collected during preliminary
investigation (Figure 1) Second team-
work-related problems particularly in relation to
communication and information relay are well
addressed This may be attributed to the dec-
ade-long institution-wide routine crew resource
management training in the respective research
hospital (Figure 2) Third the HFACS success-
fully reflects the importance of supervisory roles
in the occurrence of AMEs and this cannot be
overlooked (Figure 3) Fourth latent failures
especially in organizational climate or cultural
dimensions have been less frequently addressed
in incident reports a limitation of traditional
RCA However the HFACS review suggests
room for improvement in resource allocation and
policy modification within the hospital The
results of studies can make the organization
think about how to improve the patient safety
and management process from the perspective of
human factors such as improving the comfort of
the working environment and replacing and
equipment resources to prevent personnel from
affecting the medical quality and patient safety
due to the environment or equipment Need to
appropriate assessment of applicability and ade-
quate training of manpower is required The
management and control of risks should be fully
evaluate and grasp resource management and
leaders need to participate in and promote medi-
cal quality and patient safety activities to en-
hance its culture (Figure 4) No panacea exists
to ensure patient safety and improvement targets
originate largely from event investigation find-
ings Unfortunately factors identified from
AMEs are often self-explanatory with little value
for further action correction Reinforcement of
policy or processes redundant education or
repetitious training are formulaic overprescribed
RCA recommendations The use of HFACS in
this study proves that a structural prospective
AME investigation format can potentially help
with proactive patient safety management We
suggest developing an interview guideline for
the routine use of HFACS as a complement to
RCA in every AME investigation This study is a
retrospective study The underlying human fac-
tors can be under-estimated owing to the lack of
related information in the original RCA reports
CONCLUSION The HFACS review in this study enhances our
understanding of human factors in AMEs that
had previously been insufficiently scrutinized
Aside from active process and communication
errors the HFACS enables the prospective in-
vestigation of latent supervisory organizational
or systematic problems that cannot be addressed
through traditional RCA
REFERENCES 1 T Brennan L Leape N Laird et al
Incidence of adverse events and
negligence in hospitalized patients results
of the Harvard Medical Practice Study I N
Engl J Med 1991324370-376
2 Wang CH Shih CL Chen WJ et al
Epidemiology of medical adverse events
perspectives from a single institute in
Taiwan J Formos Med Assoc
2016115434-439
3 Vincent C Simon R Sutcliffe K et al
Errors Conference Executive Summary
Acad Emerg Med 200071180-1182
4 Taitz J Genn K Brooks V et al
System-wide learning from root cause
analysis A report from the New South
Wales Root Cause Analysis Review
Committee Qual Saf Health Care
2010191-5
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 103
5 Hutchinson A Young TA Cooper KL et
al Trends in healthcare incident reporting
and relationship to safety and quality data
in acute hospitals results from the
National Reporting and Learning System
Qual Saf Health Care 2009185-10
6 Mitchell RJ Williamson AM Molesworth
B et al A review of the use of human
factors classification frameworks that
identify causal factors for adverse events
in the hospital setting Ergonomics
2014571443-1472
7 Gurses AP Ozok AA Pronovost PJ Time
to accelerate integration of human factors
and ergonomics in patient safety BMJ
Qual Saf 201221347-351
8 Health and Safety Executive Introduction
to human factors
httpwwwhsegovukhumanfactorsintro
ductionhtm
9 Wiegmann DA Shappell SA A human
error approach to aviation accident
analysis The human factors analysis and
classification system Burlington VT
Ashgate Publishing Ltd 2003
10 Yu-Hsun Cheng Sheng-Hui Hung
Tung-Wen Ko et al An Analysis of the
Reliability and Validity of Human Factors
Analysis Classification System in Medical
Adverse Events Journal of Healthcare
Quality 20191370-76
11 Taiwan Joint Commission on Hospital
Accreditation Taiwan Patient-Safety
Reporting System Annual Report 2017
New Taipei City Taiwan
12 Taiwan Patient Safety Net
httpwwwpatientsafetymohwgovtwCo
ntentzMessagesslistaspxSiteID=1ampMm
mID=621273300317401756
13 Government of Western Australia
Department of Health
httpsww2healthwagovauArticlesS_T
Severity-assessment-codes
14 Farley DO Haviland A Champagne S et
al Adverse-event-reporting practices by
US hospitals results of a national survey
Qual Saf Health Care 200817416-423
15 Shojania KG Thomas EJ Trends in
adverse events over time why are we not
improving BMJ Qual Saf
201322273-277
16 Levitt P Challenging the systems approach
why adverse event rates are not improving
BMJ Qual Saf 2014231051-1052
17 Kellogg KM Hettinger Z Shah M et al
Our current approach to root cause
analysis is it contributing to our failure to
improve patient safety BMJ Qual Saf
201726381-387
18 Khorsandi M Skouras C Beatson K et al
Quality review of an adverse incident
reporting system and root cause analysis of
serious adverse surgical incidents in a
teaching hospital of Scotland Patient Saf
Surg 2012621
19 Diller T Helmrich G Dunning S et al
The Human Factors Analysis
Classification System (HFACS) Applied to
Health Care Am J Med Qual
201429181-190
20 Carayon P Xie A Kianfar S Human
factors and ergonomics as a patient safety
practice BMJ Qual Saf 201423196-205
21 Reason J Human Error New York
Cambridge University Press 1990
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 104
TABLE
Table 1 Incidences by Category (N=40)
CategorySAC SAC 4 SAC 3 SAC 2 SAC 1 total
Laboratory and ex-
amination events
4 10 2 0 16 (400)
Clinical care event 6 2 1 0 9 (225)
Medication event 5 0 2 0 7 (175)
Surgery-related event 1 1 2 0 4 (100)
Transfusion-related
event
1 1 0 0 2 (50)
Tube event 0 1 0 0 1 (25)
Public accident 0 0 1 0 1 (26)
Total 17 (425) 15 (375) 8 (200) 0 40 (100)
SAC 1113 Severity Assessment Code SAC
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 105
FIGURES
Figure 1 Active Failures (N=40)
16 (167)
66 (1000)
640 (150)
235 (57)
735 (200)
2435 (686)
2435 (686)
3540 (875)
438 (105)
438 (105)
738 (184)
1938 (500)
3138 (816)
3840 (950)
0 5 10 15 20 25 30 35 40
Commits WidespreadRoutine Violation
Performs Work-Around Violation
Ignored a CautionWarning
Failure to Prioritize Tasks Adequately
Wrong Choice of Action During an Operation
Inadequate Real‐Time Risk Assessment
Rushed or Delayed a Necessary Action
Breakdown in Visual Scan
Over-ControlledUnder-Controlled AircraftVehicleSystem
Unintended Operation of Equipment
Procedure Not Followed Correctly
Performance-Based Errors
Judgment and Decision Making Errors
Violations
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 106
Figure 2 Preconditions (Latent Failures or Conditions) (N=40)
14 (250)
24 (500)
48 (500)
11 (1000)
18 (125)
840 (200)
0 5 10 15 20 25 30 35 40
Seat and Restraint System Problems
Instrumentation amp Warning System Issues
Noise Interference
Environment
Physical Environment
Technological Environment
27 (286)
27 (286)
27 (286)
37 (129)
47 (511)
47 (571)
77 (1000)
24 (500)
44 (1000)
47 (571)
12 (500)
22 (1000)
27 (286)
740 (175)
0 5 10 15 20 25 30 35 40
Technical or Procedural Knowledge Not Retained After Training
InterferenceInterruption
Task OverUnder Saturation
Distraction
Negative Habit Transfer
Not Paying Attention
Complacency
Overconfidence
Physical IllnessInjury
Fatigue
Physical and Mental State
Physical Problem
State of Mind
Mental Awareness
211 (182)
311 (273)
311 (273)
411 (364)
811 (7227)
911 (818)
1140 (275)
0 5 10 15 20 25 30 35 40
Inadequate Task Delegation
TaskMission PlanningBriefingDebriefing Inadequate
Failure of CrewTeam Leadership
StandardProper Terminology Not Used
Critical Information Not Communicated
Failed to Effectively Communicate
Teamwork
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 107
Figure 3 Supervision (Direct Supervisory Chain of Command) (N=40)
Figure 4 Organization Influence (Upper-Level Management Command Level) (N=40)
114 (71)
114 (71)
214 (143)
314 (214)
1314 (929)
1440 (350)
511 (455)
511 (455)
711 (636)
1140 (275)
47 (571)
67 (857)
740 (175)
0 5 10 15 20 25 30 35 40
Selected Individual with Lack of Proficiency
Improper Role‐modeling
Failed to Provide Proper Training
Failed to IdentifyCorrect Risky or Unsafe Practices
SupervisoryCommand Oversight Inadequate
Performed Inadequate Risk Assessment ‐Formal
Selected Individual with Lack of Current or Limited Experience
Authorized Unnecessary Hazard
Allowing Unwritten Policies to Become Standard
Failure to Enforce Existing Rules
Supervisory Violations
Planned Inappropriate Operations
Inadequate Supervision
12 (500)
12 (500)
240 (50)
110 (100)
510 (500)
1040 (250)
11 (1000)
140 (25)
18 (125)
18 (125)
38 (35)
48 (500)
840 (200)
0 5 10 15 20 25 30 35 40
Organizational Over-confidence or Under-confidence in Equipment
Organizational Culture (attitude actions) Allows for Unsafe TaskMission
Purchasing or Providing Poorly Designed or Unsuitable Equipment
Organizational ProgramPolicy Risks not Adequately Assessed
Failure to Provide Adequate Manning Staffing Resources
Failure to remove inadequate worn-out equipment in timely manner
Inadequate infrastructure
Command and control resources are deficient
Failure to provide adequate operational information resources
Resource Problems
Personnel Selection amp Staffing
Policy and Process Issues
ClimateCulture Influences
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 108
Supplement Table 1- HFACS Content of Human Factor Analysis Classifi-
cation System [9] Tier main level sub-item nano code
Tier 1 Unsafe Acts
Perfor-
mance-Based
Errors
Unintended operation of equipment
Checklist not followed correctly
Procedure not followed correctly
Over-controlledunder-controlled aircraftvehiclesystem
Breakdown in visual scan
Rushed or delayed a necessary action
Judgment amp De-
cision-Making
Errors
Inadequate real‐time risk assessment
Failure to prioritize tasks adequately
Ignored a cautionwarning
Wrong choice of action during an operation
Violations
Performs work-around violation
Commits widespreadroutine violation
Extreme violation-lack of discipline
Tier 2 Preconditions
Environment
Physical environment
Environmental conditions affecting vision
Vibration effects vision or balance
Heatcold stress impairs performance
External force of object impeded an individualrsquos
movement
Lights of other vehiclevesselaircraft affected vision
Noise interference
Technological environment
Seat and restraint system problems
Instrumentation amp warning system issues
Visibility restrictions (not weather related)
Controls and switches are inadequate
Automated system creates unsafe situation
Workspace incompatible with operation
Personal equipment interference
Communication equipment inadequate
Physical and
Mental State
Physical problem
Substance effects (alcohol supplements medications
drugs)
Loss of consciousness (sudden or prolonged onset)
Physical illnessinjury
Fatigue
Inadequate adaptation to darkness
Dehydration
Body sizemovement limitations
Physical strength amp coordination (inappropriate for
task demands)
Nutritiondiet
State of mind
Psychological problem
Life stressors
Emotional state
Personality style
Overconfidence
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 109
Pressing
Complacency
Motivation
Motivational exhaustion (burnout)
Sensory misperception
Motion illusion-kinesthetic
Turning illusionbalance-vestibular
Visual illusion
Misperception of changing environment
Misinterpreted misread instrument
Misinterpretation of auditorysound cues
Spatial disorientation
Temporaltime distortion
Mental awareness
Not paying attention
Fixation
Task overunder saturation
Confusion
Negative habit transfer
Distraction
Geographically lost
Interferenceinterruption
Technical or procedural knowledge not retained after
training
Inaccurate expectation
Teamwork
Failure of crewteam leadership
Inadequate task delegation
Rankposition intimidation
Lack of assertiveness
Critical information not communicated
Standardproper terminology not used
Failed to effectively communicate
Taskmission planningbriefingdebriefing inadequate
Tier 3 Supervision
Supervisory Vio-
lations
Failure to enforce existing rules
Allowing unwritten policies to become standard
Directed individual to violate existing regulations
Authorized unqualified individuals for task
Planned Inappro-
priate Operations
Directed task beyond personnel capabilities
Inappropriate team composition
Selected individual with lack of current or limited experience
Performed inadequate risk assessment ‐formal
Authorized unnecessary hazard
Inadequate Su-
pervision
Supervisorycommand oversight inadequate
Improper role‐modeling
Failed to provide proper training
Failed to provide appropriate policyguidance
Personality conflict with supervisor
Lack of supervisory responses to critical information
Failed to identifycorrect risky or unsafe practices
Selected individual with lack of proficiency
Tier 4 Organizational
Influences
Resource Prob-
lems
Command and control resources are deficient
Inadequate infrastructure
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 110
Failure to remove inadequate worn-out equipment in timely
manner
Failure to provide adequate operational information resources
Fail to provide adequate funding
Personnel Selec-
tion amp Staffing
Personnel recruiting amp selection policies are inadequate
Failure to provide adequate manning staffing resources
Policy amp Process
Issues
Pace of ops-tempoworkload
Organizational programpolicy risks not adequately assessed
Provided inadequate procedural guidance or publications
Organizational (formal) training is inadequate or unavailable
Flawed doctrinephilosophy
Inadequate program management
Purchasing or providing poorly designed or unsuitable equip-
ment
ClimateCulture
Influences
Organizational culture (attitude actions) allows for unsafe
taskmission
Organizational over-confidence or under-confidence in equip-
ment
Unit missionaircraftvehicleequipment change or unit deacti-
vation
Organizational structure is unclear or inadequate
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 111
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
以 HFACS重新檢視根本原因分析案例挖掘造成醫療不良
事件之人為因素
鄭伃洵 1洪聖惠 12柯彤文 3王拔群 14
中文摘要
背景醫療不良事件(AMEs)的管理是促進病人安全的基石根本原因分析
(RCA)是探討重大病人安全不良事件問題但是由於無法解釋更廣泛的因素而受
到限制本研究使用人為因素分類與分析工具(HFACS)回溯審視醫療不良事件
以了解影響醫療不良事件的人為因素及各層面中錯誤原因之分佈或系統性問題
方法本研究回溯 2012-2016年間有做過根本原因分析之醫療不良事件以連續
性取樣方式(continuous sampling)收集 40例醫療不良事件以人為因素分類與分
析工具(HFACS)去系統性的挖掘每件案例發生錯誤之原因結果在行為層面中
分析結果主要為基礎技能錯誤(95)判斷和決策錯誤(875)其中在基礎技能
錯誤當中以未依程序作業執行(816)及未如預期設備操作(50)佔多數判斷和
決策錯誤中以現場風險評估不確實(686)及採取錯的步驟行為(686)佔多數
而在先決條件層面中以團隊合作(275)為主要因素包含溝通不良(818)及重
要訊息未以正確的方式即時傳達(727)佔多數在監督層面當中以監督不周
(929)或監督不妥當(929)為主要因素在組織政策和流程方面(50)以組織
系統的政策風險未充分評估(35)為主要因素結論本研究進一步了解醫療不
良事件在過去使用根本原因分析未探討到的人為因素反映出潛在的監督組織
行為或系統性的問題促進病人安全預防錯誤再發生
關鍵字病人安全醫療不良事件根本原因分析人為因素
1國泰醫療財團法人國泰綜合醫院 品質管理部
2國立臺灣大學健康政策與管理研究所
3振興醫療財團法人振興醫院 醫療品質管理中心
4輔仁大學醫學院
通訊作者王拔群 電子信箱 drtonyseednettw
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin 112
Submitted January 20 2020
Final version accepted April13
2020
Case Report
Juvenile Caruncular Atypical Lymphoid
Proliferation ndash A Rare Case Report
Cite as Hua-Wei Shih Yu-Chi Lin
Juvenile Caruncular Atypical
Lymphoid Proliferation ndash A Rare
Case Report Fu-Jen Journal of
Medicine 3(3) 112-119 2020
DOI
103966181020932020091803003
Hua-Wei Shih1 Yu-Chi Lin
1
1Department of Ophthalmology Shin Kong Wu Ho-Su Memorial Hos-
pital Taipei City Taiwan
Corresponding author E-mail address
yuchi067gmailcom (Yu-Chi Lin)
ABSTRACT
Lesions of the caruncle are very rare Most caruncular lesions are benign though there were still few reported malignant lesions Ocular adnexal lymphoproliferative disease (OALD) one of the differential diagnosis of caruncular lesion is seldom seen in young pa-tient In this article we report a 16-year-old boy with recurrent caruncular atypical lym-phoid proliferation We discuss the epidemiology clinical features images histomorpholo-gy and treatment between ocular adnexal lymphomas (OAL) and reactive lymphoid hyper-plasia (RLH)
Keywords caruncular lesion ocular adnexal lymphoproliferative disease ocular adnexal lymphoma
reactive lymphoid hyperplasia atypical lymphoid proliferation
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
113
INTRODUCTION Lesions of the caruncle are very rare Differen-
tial diagnosis includes nevus myeloproliferative
disorders tumors inflammation infection cysts
vascular lesions and fibrous Biopsy is essential
for diagnosis Levy J et al reported ocular ad-
nexal lymphoproliferative disease (OALD) was
relatively uncommon diagnosis among caruncu-
lar lesions [1]
OALD was seldom described in Asian popula-
tion especially for young age C-Y Cheng re-
ported age-standardized incidence of ocular
adnexal lymphomas (OAL) in Taiwan from 1979
to 1996 was below 07 per million per year and
mean age was 531 years old [2] In 2015 five
Taiwanese cases of OAL whose age ranging
from 45 to 64 were presented [3] However
there were few cases of conjunctival OAL or
RLH in Chinese pediatric patient
Here we present a case of 16-year-old boy with a
caruncular mass at his left eye with recurrence
one month after excision We describe his clini-
cal symptoms photographs pathological results
management and follow-up clinical course in
this report
CASE REPORT A 16-year-old healthy boy presented a mass
lesion at his left eye caruncle accompanied with
the symptom of tearing for one month (Figure 1)
He had no ocular pain no itchiness no blurred
vision no night sweating no fever and no body
weight loss The patient denied systemic diseas-
es and histories of surgery His bilateral best
corrected visual acuity (BCVA) were 66 and
intraocular pressure (IOP) were both within
normal range There were no remarkable find-
ings for his cornea lens fundus and physical
examination Excision was performed and the
mass was soft with fluid inside therefore con-
junctival pyogenic cyst was our initial diagnosis
However one month after the excision a pro-
truding mass recurred at the patientrsquos nasal can-
thus of left eye (Figure 2) There were some
differences compared to previous condition At
the first time the soft mass was contained in a
well-defined cyst wall which more favored py-
ogenic granulation However after short period
of recurrence solid consistency and unclear
margin were found which favored malignancy
Besides the mass partially involved beyond the
gray line of nasal part lower eyelid whereas last
time the cyst mainly extended from conjunctiva
of caruncle The second excisional biopsy was
performed Pathologic examination demonstrat-
ed abundant atypical lymphoid proliferation
(Figure 3A 3B) Immunohistochemical studies
showed that the lymphoid aggregation was
composed predominantly of CD20-positive cells
(Figure 3C) focal positive staining of CD3
(Figure 3D) CD5 CD23 CD10 and negative
staining of cyclin-D1 Unfortunately the cellular
morphology was difficult to be evaluated due to
marked crushing artifact Thus malignant lym-
phoma cannot be excluded totally
Orbital computed tomography (CT) showed a
lesion of soft tissue density at medial canthus of
left orbit without obvious nasolacrimal duct or
bony invasion (Figure 4A) Magnetic resonance
imaging (MRI) with contrast showed strong
enhancement at left medial canthus region (Fig-
ure 4B) There was no remarkable finding in the
systemic workup including complete blood
count and differential count biochemical pro-
files and 18F-fluoro-2-deoxyglucose positron
emission tomographycomputed tomography
(18F-FDG PETCT) indicating no evidence of
systemic involvement
After the second excision we preferred con-
servative management for him due to the uncer-
tainty of malignancy and to avoid side effects
from aggressive treatment No sign of recurrence
was noted after 10 months of observation The
follow-up photo was taken at three months after
the second operation (Figure 5)
DISCUSSION Ocular adnexal lymphoproliferative disease
(OALD) consists of the spectrum of lymphoid
disease affecting the tissues surrounding the eye
including ocular adnexal lymphomas (OAL) and
lymphoid hyperplasia (LH) [4] The conjunctiva
is an important location for extranodal lympho-
ma development which comprises 25 of OAL
[5]
OAL can be grouped into two categories based
on their appearance of cells under the micro-
scope low-grade and high-grade [6] Extranodal
marginal zone lymphoma of mucosa-associated
lymphoid tissue (EMZLMALT) is the most
common subtype of OAL followed by follicular
lymphoma [7-9] Both of the above are
low-grade lymphomas
LH can be further divided by histopathology into
reactive lymphoid hyperplasia (RLH) and atypi-
cal lymphoid hyperplasia (ALH) RLH has to-
tally benign morphology and immunophenotype
whereas ALH has borderline lesions between
RLH and lymphoma [10] OAL and LH are
mostly seen in patients with age between 50-70
years old There are rare cases in pediatric group
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
114
[71011] In the C-Y Chengrsquos statistical report of
OAL in Taiwan only 8 patients were younger
than 15 years old among the 101 cases of ocular
lymphoma [2] According to an US study inci-
dence rates of OAL were analyzed in different
age groups the group of age over 50 had the
highest incidence rate of 574 per million per-
son-years while the 0-19 age group had the
lowest incidence rate of 009 per million per-
son-years [12] The incidence of LH was even
less than OAL [13]
Patients with OALD may be asymptomatic or
with symptoms of proptosis eyelid swelling a
palpable painless mass or conjunctival salmon
patch Diplopia visual loss pain or inflamma-
tion occurred less frequently implying more
aggressive features [714]
Orbital LH is not distinguishable from low-grade
lymphoma radiologically They both typically
present a round or lobulated mass that diffusely
moderately enhances with contrast and usually
shows homogenous hypointense or isointense to
muscle barely invasion to bone or nervous sys-
tem [10] Atypical appearances including inho-
mogeneous calcification or bony changes may
be seen in high-grade lymphoma case reports
such as ocular adnexal diffuse large B-cell lym-
phoma (DLBCL) which is one of the more ag-
gressive type of OAL [7] Whole body PET is
used for not only the evaluation of systemic
involvement but also the standard for staging
lymphoma Our patientrsquos image studies revealed
neither obvious local invasion nor systemic ma-
lignancy indicating high-grade lymphoma was
less likely Low-grade lymphoma and benign
reactive lymphoid hyperplasia were still under
consideration
Histomorphology analysis and immunohisto-
chemistry (IHC) are essential for diagnosis
Flow cytometry and polymerase chain reaction
(PCR) technique are also applied to help differ-
entiate from RLH and OAL [1016] Our case
had immunohistochemical profile of positivity
for CD20 predominantly positivity focally for
CD3 CD5 CD10 CD23 and negativity for cy-
clin-D1 BCL-6 staining was not performed in
our casersquos biopsy Thus according to the IHC
report RLH ALH and follicular lymphoma are
probable diagnosis of our patient
Radiation therapy is the standard treatment for
low-grade OAL that is classified as T1N0M0 or
T2N0M0 according to the AJCC criteria [15]
İncesoy-Ouml zdemir S et al reported a 10-year-old
boy diagnosed of MALT lymphoma who was
treated with local radiotherapy (36 Gy) and
there were no local or systemic recurrences dur-
ing his nearly four-year follow-up [17] Another
case report represented a 21-year-old man of
conjunctival follicular lymphoma treated with
surgical excision only showing no evidence of
recurrence after 8 months follow-up [18] Other
treatment options for pediatric and juvenile OAL
were performed in some case reports including
intravenous rituximab intralesional interfer-
on-α-2b topical interferon a6 systemic doxycy-
cline surgical excision and postoperative local
cryotherapy [15]
Treatment for young conjunctival RLH was less
discussed in the past In a case series article
three children (9 13 14 years old respectively)
of RLH received surgical resection without fur-
ther postoperative management and no signs of
recurrence were noted during follow-up [19]
Short-term topical and oral corticosteroids after
surgical excision were prescribed in two pediat-
ric RLH patients for their small residual mass
However poor response in both cases was nota-
ble [20]
Our patient declined to receive radiotherapy or
any further postoperative treatment mainly due
to his concerning of possible side effects (such
as dry eye and cataract)
CONCLUSION We present a rare case of caruncle mass in this
report OALD is one of the relatively uncommon
diagnosis among caruncular lesions OALD
includes benign RLH and malignant OAL
which are both mainly seen in elderly patients
even rarer in pediatric or juvenile group
The standard treatment for low-grade OAL and
RLH in young patents are still debatable How-
ever long-term follow-up is suggested for both
OAL and RLH patients Though RLH has a be-
nign and self-limited course risk of malignant
transformation is possible
REFERENCES 1 Levy J Ilsar M Deckel Y et al Lesions of
the caruncle a description of 42 cases and
a review of the literature Eye
200923(5)1004-1018
2 C-Y Cheng and W-M Hsu Incidence of
eye cancer in Taiwan an 18-year review
Eye 200418152-158
3 Chui-Lien Tsen Muh-Chiou Lin
Youn-Shen Bee et al Ocular adnexal
lymphoma Five case reports and a
literature review Taiwan Journal of
Ophthalmology 20155(2)99-102
4 Liesegang TJ Ocular adnexal
lymphoproliferative lesions Mayo Clin
Proc 199368(10)1003-1010
5 Kirkegaard MM Coupland SE Prause JU
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
115
et al Malignant lymphoma of the
conjunctiva Surv Ophthalmol
201560(5)444-458
6 Stacy RC Jakobiec FA Schoenfield L et
al Unifocal and multifocal reactive
lymphoid hyperplasia vs follicular
lymphoma of the ocular adnexa Am J
Ophthalmol 2010150(3)412-426
7 Sullivan TJ Ocular Adnexal
Lymphoproliferative Disease In Guthoff
RF Katowitz JA eds Oculoplastics and
Orbit Berlin Heidelberg Springer
20101-19
8 White Valerie A Understanding and
Classification of Ocular Lymphomas
Ocular Oncology and Pathology
20195379-386
9 Stefanovic A Lossos IS Extranodal
marginal zone lymphoma of the ocular
adnexa Blood 2009114(3)501-510
10 Andrew NH Coupland SE Pirbhai A et al
Lymphoid hyperplasia of the orbit and
ocular adnexa A clinical pathologic review
Surv Ophthalmol 201661(6)778-790
11 Ferry JA1 Fung CY Zukerberg L et al
Lymphoma of the ocular adnexa A study
of 353 cases Am J Surg Pathol
200731(2)170-184
12 WM Hassan MS Bakry HM Hassan et al
Incidence of orbital conjunctival and
lacrimal gland malignant tumors in USA
from Surveillance Epidemiology and End
Results 1973-2009 Int J Ophthalmol
20169(12)1808-1813
13 Ajay A Rao John H Naheedy James Y-Y
Chen et al A Clinical Update and
Radiologic Review of Pediatric Orbital
and Ocular Tumors Journal of Oncology
2013(9)975908
14 Sullivan TJ Whitehead K Williamson R
et al Lymphoproliferative disease of the
ocular adnexa a clinical and pathologic
study with statistical analysis of 69
patients Ophthal Plast Reconstr Surg
200521177-188
15 Tanenbaum RE Galor A Dubovy SR et al
Classification diagnosis and management
of conjunctival lymphoma Eye Vis (Lond)
2019622
16 Olga Klavdianou Georgios Kondylis
Vasileios Georgopoulos et al Bilateral
benign reactive lymphoid hyperplasia of
the conjunctiva a case treated with oral
doxycycline and review of the literature
Eye Vis (Lond) 2019626
17 İncesoy-Ouml zdemir S Yuumlksek N Bozkurt C
et al A rare type of cancer in children
extranodal marginal zone B-cell (MALT)
lymphoma of the ocular adnexa Turk J
Pediatr 201456(3)295-298
18 Lynn J Poole Perry Frederick A Jakobiec
Peter A D Rubin Conjunctival Pediatric
Follicular Lymphoma Arch Ophthalmol
2012130(7)941-943
19 Abdullah Al-Mujaini Upender Wali
Anuradha Ganesh1 et al Ocular Adnexal
Reactive Lymphoid Hyperplasia in
Children Middle East Afr J Ophthalmol
201219(4)406-409
20 McLeod SD Edward DP Benign
lymphoid hyperplasia of the conjunctiva in
children Arch Ophthalmol
1999117(6)832-835
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
116
FIGURES
Figure 1 Slit lamp image of a mass lesion at the patientrsquos left eye caruncle for one month
Figure 2 One month after the first excision a protruding mass recurred at the patientrsquos nasal canthus
of left eye It partially involved beyond the gray line of nasal part lower eyelid
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
117
Figure 3 Histomorphology analysis and immunohistochemistry study of the caruncular lesion Abun-
dant atypical lymphoid proliferation presented in low-power photomicrograph (A) and
high-power photomicrograph (B) under hematoxylin-eosin staining The lymphoid aggrega-
tion was composed predominantly of CD20-positive cells (C) and focal positive staining of
CD3 (D)
Figure 4 Non-contrast orbital computed tomography showed a lesion of soft tissue density at medial
canthus of left orbit without obvious nasolacrimal duct or bony invasion (A) Magnetic reso-
nance imaging with contrast showed strong enhancement at left medial canthus region (B)
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
118
Figure 5 The follow-up photo were taken at three months after the second excision showing no signs
of recurrence
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
119
Juvenile Caruncular Atypical Lymphoid Proliferation ndash A Rare Case Report
罕見病例報告mdash青少年之淚阜非典型淋巴增生
施驊瑋 1林友祺 1
中文摘要
淚阜病灶相當罕見大部分為良性病灶眼睛及附屬結構淋巴增生疾病為其
鑑別診斷之一非常少見於年輕人或兒童我們報告一位 16歲的健康男性因
左眼淚阜無痛性腫塊接受切除手術卻於術後一個月復發執行第二次切除手術
後門診追蹤十個月未再復發此案例表現了部分良性與部分惡性腫瘤的特徵
我們針對反應性淋巴增生眼睛及附屬結構淋巴癌兩個疾病做討論及文獻回顧
關鍵字淚阜病灶眼睛及附屬結構淋巴增生疾病眼睛及附屬結構淋巴癌反
應性淋巴增生非典型淋巴增生
1 新光吳火獅紀念醫院眼科
通訊作者林友祺 電子信箱 yuchi067gmailcom
Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh 120
Submitted March 26 2020
Final version accepted April 16
2020
Case Report
Hyperacute intramembranous hemor-
rhage after burr hole craniostomy for
chronic subdural hematoma
Cite as Meng-Chi Lin Jui-Ming
Sun Yu-Hao Chen Cheng-Ta
Hsieh
Hyperacute intramembranous
hemorrhage after burr hole crani-
ostomy for chronic subdural he-
matoma Fu-Jen Journal of Medi-
cine 3(4) 120-125 2020
DOI
103966181020932020091803004
Meng-Chi Lin1 Jui-Ming Sun23 Yu-Hao Chen24 Cheng-Ta
Hsieh567
1Department of Surgery Zuoying Branch Kaohsiung Armed Forces
General Hospital Kaohsiung 813 Taiwan 2Section of Neurosurgery Department of Surgery Chia-Yi Christian
Hospital Chia-Yi City 600 Taiwan 3Department of Biotechnology Asia University Taichung City 41354
Taiwan 4Chung-Jen Junior College of Nursing Health Sciences and Manage-
ment Chia-Yi Country 62241 Taiwan 5Division of Neurosurgery Department of Surgery Sijhih Cathay Gen-
eral Hospital New Taipei City 22174 Taiwan 6Department of Medicine School of Medicine Fu Jen Catholic Univer-
sity New Taipei City 24205 Taiwan 7Department of Neurological Surgery Tri-Service General Hospital
National Defense Medical Center Taipei 114 Taiwan
Corresponding author E-mail address
nogormail2000comtw (Cheng-Ta Hsieh)
ABSTRACT
Burr hole craniostomy with closed-system drainage is an effective and common neurosurgical procedure to manage chronic subdural hematoma Postoperative hem-orrhage a well-known but infrequent complication may result in increased neurolog-ical deficits However hyperacute intramembranous hemorrhage within the inner and outer membrane of hematoma after burr hole craniostomy with irrigation and closed-system drainage has not been described previously Herein we report a case of postoperative spontaneous hyperacute intramembranous hemorrhage after burr hole craniostomy with closed-system drainage to manage a chronic subdural hematoma we subsequently discuss the possible pathophysiological mechanisms and review the relevant literature
Keywords Chronic subdural hematoma acute subdural hematoma bleeding burr hole craniostomy
drainage
Fu-J
Meng
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ASE REPO1-year-old wo
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of Medicine V
i-Ming Sun Y
CTION hematoma (C
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[4 6 7] Horanous bleedinCSDH has rarewe report the
developed spranous hemory Subsequenal mechanismis reviewed
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h irrigation a
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(Figure 2B)membranecto
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brane of the
Vol 3 No 4 2
Acute intram
Yu-Hao Chen
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Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh
125
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
慢性硬腦膜下出血進行鑽顱引流手術造成超急性夾膜內出
血
林孟楫 1孫瑞明 23陳昱豪 24謝政達 567
中文摘要
鑽顱併封閉系統引流手術是治療慢性硬腦膜下出血患者一種有效且常見的
神經外科手術方式術後出血可能導致神經功能缺損惡化是眾所周知但不常見
的併發症之一然而至今仍未有鑽孔併封閉系統引流造成原本慢性硬腦膜血
塊內膜和外膜間急性夾膜間出血案例在這裡我們報告一例慢性硬腦膜下出
血病患者接受鑽顱併封閉系統引流手術治療造成術後急性夾膜間出血我們在
本文中討論可能的致病機制並回顧相關文獻
關鍵字慢性硬腦膜下出血急性硬腦膜下出血出血鑽顱術引流
1國軍高雄總醫院左營分院 外科部
2崇仁醫護管理專科學校
3亞洲大學 生物科技學系
4戴德森醫療財團法人嘉義基督教醫院 外科部 神經外科
5汐止國泰綜合醫院 神經外科
6輔仁大學 醫學系
7 國防醫學院 三軍總醫院 神經外科
通訊作者謝政達 電子信箱 nogormail2000comtw
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
126
Submitted January 21 2020
Final version accepted July 08
2020
Case Report
Hamartoma of the breast A case report
Cite as Hsuan-An Chen
Cheng-Yu Lo Shih-Hung Huang
Chin-Lung Lin
Hamartoma of the breast A case
report Fu-Jen Journal of Medicine
3(5) 126-130 2020
DOI
103966181020932020091803005
Hsuan-An Chen1 Cheng-Yu Lo
3 Shih-Hung Huang
3 Chin-Lung
Lin2
1Department of Surgery Cathay General Hospital Taipei Taiwan
2Department of General Surgery Cathay General Hospital Taipei Tai-
wan
3Department of Pathology Cathay General Hospital Taipei Taiwan
Corresponding author E-mail address
lungyungmailcom (Chin-Lung Lin)
ABSTRACT
Breast hamartoma is an uncommon benign tumor rarely associated with malignancy An
excision and histological examination is necessary for the differential diagnosis We report
a case of a 49-year-old female patient presenting with a lump in the right breast Ultrasound
examination which demonstrated a 4411 cm hypoechoic lesion with lipoma Partial mas-
tectomy was arranged and the diagnosis of a hamartoma was confirmed by the histological
examination
Keywords Breast tumor Hamartoma Ultrasound
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
127
INTRODUCTION The hamartoma is a benign tumor-like lesion
that can affect various organs of the body in-
cluding lungs kidneys skin and more rarely the
breast In 1981 the hamartomas were recognized
in the WHO classification[1] They are defined
as well-demarcated mass of mammary ducts and
lobules containing varying amounts of fibrous
and adipose tissue and producing a distinctive
mammographic image
CASE REPORT A 49 year-old female had past history of left
breast mastitis with abscess status post partial
mastectomy This time she presented to our out
patient clinic for breast examination Physical
examination revealed a painless palpable mova-
ble and painless lump at upper outer quadrant of
right breast The risk of breast cancer was not
noted and the patient did not have any family
history of breast cancer The patient also denied
any trauma history before Ultrasound examina-
tion was arranged which demonstrated a 4411
cm hypoechoic lesion with lipoma at 3 oclock 2
cm from nipple of right breast and multiple hy-
poechoic nodules of various size in both breasts
and there was no suspicious axillary lymph
nodes noted (Figure1) Surgical treatment was
arranged partial mastectomy of right breast
harmartoma was successfully performed A 32 x
31 x 21 cm tumor was completely excised
Grossly examination showed a gray to yellow
and firm to fatty The diagnosis of a hamartoma
was confirmed by the histological examination
Microscopically sections of the breast lesion
show mammary hamartoma composed of ducts
lobules with interlobular fibrous tissue and adi-
pose tissue Fibrocystic change apocrine meta-
plastic ducts and scattered foci of adenosis are
noted The overall lobulocentric architecture and
the 2-cell pattern of the epithelium are preserved
columnar cell change and focal microcalcifica-
tion are present (Figure2) Based on submitted
biopsy specimen in-situ or invasive tumor cells
are not identified
DISCUSSION Hamartoma of the breast is a benign tumor like
nodule it was also known as fibroadenolipoma
lipofibroadenoma or adenolipoma based on its
predominant components It was composed of
varying amounts of glandular adipose and fi-
brous tissue[2] Hamartomas were first described
in 1971 by Arrigoni et al in a study of 10 patients
which breast tumors clinically and grossly re-
sembled fibroadenomas[3]
A higher predominance of tumors exists in fe-
males compared with males Hamartomas are
slowly-growing lesions with the diameter rang-
ing from 2 cm to 5 cm sometimes hamartomas
can reach giant diameter [4]
The clinical diagnosis of hamartoma is based on
the findings from mammography sonography
and histology examinations The hamartomas are
usually incidentally diagnosed by the women
older than 40 year-old starting mammography
screening
On physicial examination harmatomas are usu-
ally occult painless they may be as large mo-
bile soft to firm masses[5] Ultrasound showed
well capsulated mass with echogenic rim and
internal heterogeneity Mammography exam
showed well-circumscribed round to oval
masses containing fat and soft tissue densities
with a thin radiopaque pseudocapsule The
pseudocapsule results from displacement of
breast parenchyma by the tumor [56] In Pa-
thology finding microglandular adenosis is pre-
sent in fibroadipose stroma surrounded by a thin
fibrous capsule It composed of a combination of
epithelial and stromal elements usually with
normal ducts or lobules although variations of
normal tissue may also be seen Fibroadenoli-
poma myoid hamartoma and chondrolipoma are
histological variations of hamartomas depend-
ing on the proportion of normal breast tissue
elements[7]
Malignancy associated with hamartomas are
very rare[8] However it has been reported
hamartomas develop into carcinoma Malignant
transformation can occur as a result of cellular
atypia in the epithelial component of the mass[9]
Surgical removal is the curative method for
breast hamartomas[10] Diagnostic material such
as mammography ultrasonography or core nee-
dle biopsy may not give the definitive diagnosis
Therefore surgical excision and histological
examination is necessary for differential diagno-
sis[111213]
Although it is rare hamartoma can be seen along
with malignancy as it is formed from similar
components of breast tissue Therefore careful
diagnosis and appropriate management including
surgery are required
REFERENCES 1 World Health Organization (1981)
Histological typing of breast tumors In
International histological classification of
tumors 1981 2nd ed
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
128
2 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11435ndash449
2006
3 ArrigoniMG DockertyMB JuddES
The identificationand treatment of
mammary hamartoma Surg Gynecol
Obstet1971 133 577-82
4 Sanal HT Ersoz N Altinel O Unal E Can
C Giant hamartoma of the breast Breast J
2006 12 84-85
5 Feder JM de Paredes ES Hogge JP
Wilken JJ Unusual breast lesions
radiologic-pathologic correlation
Radiographics 1999 19S11ndashS26
6 Murat A Ozdemir H Yildirim H Poyraz
AK Ozercan R Hamartoma of the breast
Australas Radiol 200751 Spec NoB37ndash
9
7 Fisher CJ Hanby AM Robinson L Millis
RR Mammary hamartoma-a review of 35
cases Histopathology 1992 20 99-106
8 Choi N Ko ES Invasive ductal carcinoma
in a mammary hamartoma case report and
review of the literature Korean J Radiol
2010 Nov-Dec11(6)687-91
9 Lee EH Wylie EJ Bourke AG Bastiaan
De Boer W Invasive ductal carcinoma
arising in a breast hamartoma two case
reports and a review of the literature Clin
Radiol 2003 58 80-3
10 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11 435 ‑449
2006
11 Coyne J Hobbs FM Boggis C Harland R
Lobular carcinoma in a mammary
hamartoma J Clin Pathol 199245936ndash
937
12 G M K Tse B K B Law T K F Ma A B W
Chan Hamartoma of the breast a
clinicopathological review J Clin Pathol
200255951ndash954
13 RAAmir SSheikh BreasthamartomaA
report of 14cases of an under-recognized
and under-reported entity International
Journal of Surgery Case Reports
22(2016)1ndash4
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
129
FIGURES
Figure 1 Ultrasound shows a 4411 cm hypoechoic lesion with lipoma at 3 oclock 2 cm from nipple
of right breast
Figure 2 Photomicrograph shows mammary hamartoma composed of ducts lobules with interlobular
fibrous tissue and adipose tissue
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
130
Hamartoma of the breast A case report
乳房錯構瘤罕見個案報告
陳宣安 1羅承裕 3黃世鴻 3林錦龍 2
中文摘要
乳房錯構瘤是一種罕見之乳房良性腫瘤切除手術及病理化驗來做鑑別診斷
我們報告一位 49歲女性以可觸摸到無痛性右側乳房腫塊為臨床表徵超音波
看到一個邊緣清楚低迴音的腫塊病患接受手術切除病灶病理診斷證實為乳
房錯構瘤
關鍵字乳房腫瘤錯構瘤超音波攝影
1國泰綜合醫院外科部
2國泰綜合醫院一般外科
3國泰綜合醫院病理科
通訊作者林錦龍 電子信箱 lungyungmailcom
Fu-Jen Journal of Medicine
Mission and Goals
The Fu-Jen Journal of Medicine (FJJM) is a peer-reviewed journal which
aims to enhance research quality of staffs in the College of Medicine Fu Jen
Catholic University The journal publishes original investigations across a
wide range of medical disciplines including original research articles in basic
and clinical sciences case reports review articles brief reports and letter
to the editor FJJM is now issued by the Center of Medical Education in the
College of Medicine Fu Jen Catholic University To promote journal quality
the manuscript submitted to FJJM after August first 2015 has to be prepared
in English to meet the international standards
Issue Date
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December 01 2003
September 30 2020
College of Medicine Fu Jen Catholic University
Honorable publisher Han-Sun Chiang
Publisher Ping-Keung Yip
Editor-in-chief Ming-Chieh Ma
Associate Editors Yu-Wen Lin
Editors
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Address Center for Medical Education College of Medicine Fu Jen
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No 510 Zhongzheng Rd Xinzhuang Dist New Taipei City
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Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 101
finished human factor education and were
trained to use the HFACS through a consensus
meeting Each RCA case was randomly assigned
to 2 reviewers Human factors leading to partic-
ular AMEs were identified and confirmed when
2 reviewers reached agreement The distribution
of errors among tiers subitems and nanocodes
are provided with descriptive statistics () The
study was approved by the Institutional Review
Board of Cathay General Hospital
(CGH-P105095)
RESULTS AMEs related to laboratory testing and examina-
tion (n = 16) clinical care (n = 9) and medica-
tion (n = 7) were the most commonly observed
in the RCA Most AMEs in this cohort are
ranked as being SAC level 3 (n = 15) or 4 (n =
17) (Table 1)
Acts (Active Failures)
This tier of errors contains 3 subitems and 13
nanocodes In the 40 RCA cases perfor-
mance-based errors for 38 (95) and judgment
and decision-making errors for 35 (875) com-
prised the most common error types with viola-
tion for 6 (15) less common Procedure fol-
lowed incorrectly for 31 out of 38 (816) was
the most common performance-based problem
Inadequate real-time risk management for 24 out
of 35 (686) was the most common judgment
or decision error All of the rule violations were
workaround types for 6 out of 6 (100) (Figure
1)
Preconditions(Latent Failures)
This tier of errors has 9 subitems and 58 nano-
codes In the 40 RCA cases teamwork for 11
(275) and environmental for 8 (20) factors
contributed to most of the errors with mental
and physical state the next most common factor
for 7 (175) Communication for 9 out of 11
(818) and information relay for 8 out of 11
(727) were the most common issues related to
teamwork Few contributors mentioned failures
related to technical errors for 4 (50) or physi-
cal for 1 (125) environment Not paying at-
tention for 4 out of 7 (571) and negative habit
transfer for 4 out of 7 (571) were common
mental contributes noted for 7 (100) Overcon-
fidence was the most common problem related
to emotional status for 4 out of 7 (571) Fa-
tigue was observed in only 2 cases for 2 out of 2
physical problems (100) (Figure 2)
Supervision(Direct Supervisory Chain of
Command)
This tier of errors contains 3 subitems and 17
nanocodes In the 40 RCA cases inadequate
supervision for 14 (35) and inappropriately
planned operations for 11 (275) factors con-
tributed to most of the respective errors fol-
lowed by supervisory violations for 7 (175)
Supervisory or command oversights for 13 out
of 14 (929) were the most common sources of
supervision inadequacy Authorized unnecessary
hazards for 7 out of 11 (636) were the most
common inappropriately planned operations
Failure to enforce rules for 6 out of 7 (857)
was the most common supervisory violation
(Figure 3)
Organization Influence (Upper-Level Man-
agement)
This tier of errors contains 4 subitems and 18
nanocodes In the 40 RCA cases policy and
process issues for 10 (25) and resources prob-
lem for 8 (20) were major concerns Few of
the respective problems are related to climate
and cultural influences for 2 (5) or to person-
nel selection and staffing for 1 (25) Poorly
assessed organizational programs or policy risks
for 5 out of 10 (50) were the most common
policy and process problems Failure to provide
adequate operational information resources for 4
out of 8 (50) and command and control re-
source deficiency for 3 out of 8 (375) were
the main resource management problems Little
was revealed regarding organizational climate
and culture (n = 1 out of 2 50) or staffing for 1
out of 1 (100) (Figure 4)
DISCUSSION Health care is a complex system comprising
many high-reliability organizations (HROs) The
vulnerability of HROs stems from the participa-
tion of multidisciplinary teams in the processes
along a variety of patient care timelines How-
ever humans and systems are inherently prone
to errors the appropriate management of AMEs
is acknowledged to be the cornerstone of patient
safety AMEs should be reported investigated
analyzed and handled appropriately[14] Theo-
retically by analyzing the pattern of key defects
providers can fix errors and re-engineer their
care processes to reduce the possibility of AME
recurrence Taiwan established its nationwide
TPR in 2004 so far 7000 health care facilities
have participated and the database has accumu-
lated more than 055 million AMEs[11] Infor-
mation generated from the TPR database can
improve patient safety at individual organiza-
tional or even national levels However despite
relentless efforts few substantial improvements
have been achieved in patient safety [15-17]
Since its introduction in Taiwan in 2006 the use
of RCA for AMEs has encountered some diffi-
culties 1) No structural and standardized
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 102
framework exists for investigation
cross-institution variability and interrater relia-
bility are often ignored 2) Conclusions are often
subjective and corrective recommendations are
less actionable relying on individual reviewersrsquo
professional backgrounds and their experiences
3) Much focus on event reconstruction and oper-
ator performance means that factors relating to
human behavior organizational culture and
system weakness are not comprehensively ad-
dressed [671718] Traditionally attempts to
improve patient safety in the health care industry
are largely reactive in nature identifying and
correcting errors in care processes [1920]
Causes of defects are not thoroughly understood
Proactive approaches must be taken to address
systematic problems within a complex system
[720] Research suggests that human error is a
causal factor in the occurrence of AMEs AME
investigation targets have moved from skill defi-
ciency toward decision-making attitudes super-
visory factors and even organizational climate
or culture HFACS methodology is based on the
Swiss cheese model that also emphasizes active
and latent failures [921] The study provides
some noteworthy findings First most AMEs as
expected involve active failures such as failure
to follow procedure accidental operation of
equipment inadequate real-time risk manage-
ment and inappropriate action These are all
sharp ends in classic RCA environment physi-
cal and mental factors are less prevalent This
proves that retrospectively determining addi-
tional causal factors is difficult when infor-
mation has not been collected during preliminary
investigation (Figure 1) Second team-
work-related problems particularly in relation to
communication and information relay are well
addressed This may be attributed to the dec-
ade-long institution-wide routine crew resource
management training in the respective research
hospital (Figure 2) Third the HFACS success-
fully reflects the importance of supervisory roles
in the occurrence of AMEs and this cannot be
overlooked (Figure 3) Fourth latent failures
especially in organizational climate or cultural
dimensions have been less frequently addressed
in incident reports a limitation of traditional
RCA However the HFACS review suggests
room for improvement in resource allocation and
policy modification within the hospital The
results of studies can make the organization
think about how to improve the patient safety
and management process from the perspective of
human factors such as improving the comfort of
the working environment and replacing and
equipment resources to prevent personnel from
affecting the medical quality and patient safety
due to the environment or equipment Need to
appropriate assessment of applicability and ade-
quate training of manpower is required The
management and control of risks should be fully
evaluate and grasp resource management and
leaders need to participate in and promote medi-
cal quality and patient safety activities to en-
hance its culture (Figure 4) No panacea exists
to ensure patient safety and improvement targets
originate largely from event investigation find-
ings Unfortunately factors identified from
AMEs are often self-explanatory with little value
for further action correction Reinforcement of
policy or processes redundant education or
repetitious training are formulaic overprescribed
RCA recommendations The use of HFACS in
this study proves that a structural prospective
AME investigation format can potentially help
with proactive patient safety management We
suggest developing an interview guideline for
the routine use of HFACS as a complement to
RCA in every AME investigation This study is a
retrospective study The underlying human fac-
tors can be under-estimated owing to the lack of
related information in the original RCA reports
CONCLUSION The HFACS review in this study enhances our
understanding of human factors in AMEs that
had previously been insufficiently scrutinized
Aside from active process and communication
errors the HFACS enables the prospective in-
vestigation of latent supervisory organizational
or systematic problems that cannot be addressed
through traditional RCA
REFERENCES 1 T Brennan L Leape N Laird et al
Incidence of adverse events and
negligence in hospitalized patients results
of the Harvard Medical Practice Study I N
Engl J Med 1991324370-376
2 Wang CH Shih CL Chen WJ et al
Epidemiology of medical adverse events
perspectives from a single institute in
Taiwan J Formos Med Assoc
2016115434-439
3 Vincent C Simon R Sutcliffe K et al
Errors Conference Executive Summary
Acad Emerg Med 200071180-1182
4 Taitz J Genn K Brooks V et al
System-wide learning from root cause
analysis A report from the New South
Wales Root Cause Analysis Review
Committee Qual Saf Health Care
2010191-5
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 103
5 Hutchinson A Young TA Cooper KL et
al Trends in healthcare incident reporting
and relationship to safety and quality data
in acute hospitals results from the
National Reporting and Learning System
Qual Saf Health Care 2009185-10
6 Mitchell RJ Williamson AM Molesworth
B et al A review of the use of human
factors classification frameworks that
identify causal factors for adverse events
in the hospital setting Ergonomics
2014571443-1472
7 Gurses AP Ozok AA Pronovost PJ Time
to accelerate integration of human factors
and ergonomics in patient safety BMJ
Qual Saf 201221347-351
8 Health and Safety Executive Introduction
to human factors
httpwwwhsegovukhumanfactorsintro
ductionhtm
9 Wiegmann DA Shappell SA A human
error approach to aviation accident
analysis The human factors analysis and
classification system Burlington VT
Ashgate Publishing Ltd 2003
10 Yu-Hsun Cheng Sheng-Hui Hung
Tung-Wen Ko et al An Analysis of the
Reliability and Validity of Human Factors
Analysis Classification System in Medical
Adverse Events Journal of Healthcare
Quality 20191370-76
11 Taiwan Joint Commission on Hospital
Accreditation Taiwan Patient-Safety
Reporting System Annual Report 2017
New Taipei City Taiwan
12 Taiwan Patient Safety Net
httpwwwpatientsafetymohwgovtwCo
ntentzMessagesslistaspxSiteID=1ampMm
mID=621273300317401756
13 Government of Western Australia
Department of Health
httpsww2healthwagovauArticlesS_T
Severity-assessment-codes
14 Farley DO Haviland A Champagne S et
al Adverse-event-reporting practices by
US hospitals results of a national survey
Qual Saf Health Care 200817416-423
15 Shojania KG Thomas EJ Trends in
adverse events over time why are we not
improving BMJ Qual Saf
201322273-277
16 Levitt P Challenging the systems approach
why adverse event rates are not improving
BMJ Qual Saf 2014231051-1052
17 Kellogg KM Hettinger Z Shah M et al
Our current approach to root cause
analysis is it contributing to our failure to
improve patient safety BMJ Qual Saf
201726381-387
18 Khorsandi M Skouras C Beatson K et al
Quality review of an adverse incident
reporting system and root cause analysis of
serious adverse surgical incidents in a
teaching hospital of Scotland Patient Saf
Surg 2012621
19 Diller T Helmrich G Dunning S et al
The Human Factors Analysis
Classification System (HFACS) Applied to
Health Care Am J Med Qual
201429181-190
20 Carayon P Xie A Kianfar S Human
factors and ergonomics as a patient safety
practice BMJ Qual Saf 201423196-205
21 Reason J Human Error New York
Cambridge University Press 1990
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 104
TABLE
Table 1 Incidences by Category (N=40)
CategorySAC SAC 4 SAC 3 SAC 2 SAC 1 total
Laboratory and ex-
amination events
4 10 2 0 16 (400)
Clinical care event 6 2 1 0 9 (225)
Medication event 5 0 2 0 7 (175)
Surgery-related event 1 1 2 0 4 (100)
Transfusion-related
event
1 1 0 0 2 (50)
Tube event 0 1 0 0 1 (25)
Public accident 0 0 1 0 1 (26)
Total 17 (425) 15 (375) 8 (200) 0 40 (100)
SAC 1113 Severity Assessment Code SAC
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 105
FIGURES
Figure 1 Active Failures (N=40)
16 (167)
66 (1000)
640 (150)
235 (57)
735 (200)
2435 (686)
2435 (686)
3540 (875)
438 (105)
438 (105)
738 (184)
1938 (500)
3138 (816)
3840 (950)
0 5 10 15 20 25 30 35 40
Commits WidespreadRoutine Violation
Performs Work-Around Violation
Ignored a CautionWarning
Failure to Prioritize Tasks Adequately
Wrong Choice of Action During an Operation
Inadequate Real‐Time Risk Assessment
Rushed or Delayed a Necessary Action
Breakdown in Visual Scan
Over-ControlledUnder-Controlled AircraftVehicleSystem
Unintended Operation of Equipment
Procedure Not Followed Correctly
Performance-Based Errors
Judgment and Decision Making Errors
Violations
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 106
Figure 2 Preconditions (Latent Failures or Conditions) (N=40)
14 (250)
24 (500)
48 (500)
11 (1000)
18 (125)
840 (200)
0 5 10 15 20 25 30 35 40
Seat and Restraint System Problems
Instrumentation amp Warning System Issues
Noise Interference
Environment
Physical Environment
Technological Environment
27 (286)
27 (286)
27 (286)
37 (129)
47 (511)
47 (571)
77 (1000)
24 (500)
44 (1000)
47 (571)
12 (500)
22 (1000)
27 (286)
740 (175)
0 5 10 15 20 25 30 35 40
Technical or Procedural Knowledge Not Retained After Training
InterferenceInterruption
Task OverUnder Saturation
Distraction
Negative Habit Transfer
Not Paying Attention
Complacency
Overconfidence
Physical IllnessInjury
Fatigue
Physical and Mental State
Physical Problem
State of Mind
Mental Awareness
211 (182)
311 (273)
311 (273)
411 (364)
811 (7227)
911 (818)
1140 (275)
0 5 10 15 20 25 30 35 40
Inadequate Task Delegation
TaskMission PlanningBriefingDebriefing Inadequate
Failure of CrewTeam Leadership
StandardProper Terminology Not Used
Critical Information Not Communicated
Failed to Effectively Communicate
Teamwork
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 107
Figure 3 Supervision (Direct Supervisory Chain of Command) (N=40)
Figure 4 Organization Influence (Upper-Level Management Command Level) (N=40)
114 (71)
114 (71)
214 (143)
314 (214)
1314 (929)
1440 (350)
511 (455)
511 (455)
711 (636)
1140 (275)
47 (571)
67 (857)
740 (175)
0 5 10 15 20 25 30 35 40
Selected Individual with Lack of Proficiency
Improper Role‐modeling
Failed to Provide Proper Training
Failed to IdentifyCorrect Risky or Unsafe Practices
SupervisoryCommand Oversight Inadequate
Performed Inadequate Risk Assessment ‐Formal
Selected Individual with Lack of Current or Limited Experience
Authorized Unnecessary Hazard
Allowing Unwritten Policies to Become Standard
Failure to Enforce Existing Rules
Supervisory Violations
Planned Inappropriate Operations
Inadequate Supervision
12 (500)
12 (500)
240 (50)
110 (100)
510 (500)
1040 (250)
11 (1000)
140 (25)
18 (125)
18 (125)
38 (35)
48 (500)
840 (200)
0 5 10 15 20 25 30 35 40
Organizational Over-confidence or Under-confidence in Equipment
Organizational Culture (attitude actions) Allows for Unsafe TaskMission
Purchasing or Providing Poorly Designed or Unsuitable Equipment
Organizational ProgramPolicy Risks not Adequately Assessed
Failure to Provide Adequate Manning Staffing Resources
Failure to remove inadequate worn-out equipment in timely manner
Inadequate infrastructure
Command and control resources are deficient
Failure to provide adequate operational information resources
Resource Problems
Personnel Selection amp Staffing
Policy and Process Issues
ClimateCulture Influences
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 108
Supplement Table 1- HFACS Content of Human Factor Analysis Classifi-
cation System [9] Tier main level sub-item nano code
Tier 1 Unsafe Acts
Perfor-
mance-Based
Errors
Unintended operation of equipment
Checklist not followed correctly
Procedure not followed correctly
Over-controlledunder-controlled aircraftvehiclesystem
Breakdown in visual scan
Rushed or delayed a necessary action
Judgment amp De-
cision-Making
Errors
Inadequate real‐time risk assessment
Failure to prioritize tasks adequately
Ignored a cautionwarning
Wrong choice of action during an operation
Violations
Performs work-around violation
Commits widespreadroutine violation
Extreme violation-lack of discipline
Tier 2 Preconditions
Environment
Physical environment
Environmental conditions affecting vision
Vibration effects vision or balance
Heatcold stress impairs performance
External force of object impeded an individualrsquos
movement
Lights of other vehiclevesselaircraft affected vision
Noise interference
Technological environment
Seat and restraint system problems
Instrumentation amp warning system issues
Visibility restrictions (not weather related)
Controls and switches are inadequate
Automated system creates unsafe situation
Workspace incompatible with operation
Personal equipment interference
Communication equipment inadequate
Physical and
Mental State
Physical problem
Substance effects (alcohol supplements medications
drugs)
Loss of consciousness (sudden or prolonged onset)
Physical illnessinjury
Fatigue
Inadequate adaptation to darkness
Dehydration
Body sizemovement limitations
Physical strength amp coordination (inappropriate for
task demands)
Nutritiondiet
State of mind
Psychological problem
Life stressors
Emotional state
Personality style
Overconfidence
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 109
Pressing
Complacency
Motivation
Motivational exhaustion (burnout)
Sensory misperception
Motion illusion-kinesthetic
Turning illusionbalance-vestibular
Visual illusion
Misperception of changing environment
Misinterpreted misread instrument
Misinterpretation of auditorysound cues
Spatial disorientation
Temporaltime distortion
Mental awareness
Not paying attention
Fixation
Task overunder saturation
Confusion
Negative habit transfer
Distraction
Geographically lost
Interferenceinterruption
Technical or procedural knowledge not retained after
training
Inaccurate expectation
Teamwork
Failure of crewteam leadership
Inadequate task delegation
Rankposition intimidation
Lack of assertiveness
Critical information not communicated
Standardproper terminology not used
Failed to effectively communicate
Taskmission planningbriefingdebriefing inadequate
Tier 3 Supervision
Supervisory Vio-
lations
Failure to enforce existing rules
Allowing unwritten policies to become standard
Directed individual to violate existing regulations
Authorized unqualified individuals for task
Planned Inappro-
priate Operations
Directed task beyond personnel capabilities
Inappropriate team composition
Selected individual with lack of current or limited experience
Performed inadequate risk assessment ‐formal
Authorized unnecessary hazard
Inadequate Su-
pervision
Supervisorycommand oversight inadequate
Improper role‐modeling
Failed to provide proper training
Failed to provide appropriate policyguidance
Personality conflict with supervisor
Lack of supervisory responses to critical information
Failed to identifycorrect risky or unsafe practices
Selected individual with lack of proficiency
Tier 4 Organizational
Influences
Resource Prob-
lems
Command and control resources are deficient
Inadequate infrastructure
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 110
Failure to remove inadequate worn-out equipment in timely
manner
Failure to provide adequate operational information resources
Fail to provide adequate funding
Personnel Selec-
tion amp Staffing
Personnel recruiting amp selection policies are inadequate
Failure to provide adequate manning staffing resources
Policy amp Process
Issues
Pace of ops-tempoworkload
Organizational programpolicy risks not adequately assessed
Provided inadequate procedural guidance or publications
Organizational (formal) training is inadequate or unavailable
Flawed doctrinephilosophy
Inadequate program management
Purchasing or providing poorly designed or unsuitable equip-
ment
ClimateCulture
Influences
Organizational culture (attitude actions) allows for unsafe
taskmission
Organizational over-confidence or under-confidence in equip-
ment
Unit missionaircraftvehicleequipment change or unit deacti-
vation
Organizational structure is unclear or inadequate
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 111
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
以 HFACS重新檢視根本原因分析案例挖掘造成醫療不良
事件之人為因素
鄭伃洵 1洪聖惠 12柯彤文 3王拔群 14
中文摘要
背景醫療不良事件(AMEs)的管理是促進病人安全的基石根本原因分析
(RCA)是探討重大病人安全不良事件問題但是由於無法解釋更廣泛的因素而受
到限制本研究使用人為因素分類與分析工具(HFACS)回溯審視醫療不良事件
以了解影響醫療不良事件的人為因素及各層面中錯誤原因之分佈或系統性問題
方法本研究回溯 2012-2016年間有做過根本原因分析之醫療不良事件以連續
性取樣方式(continuous sampling)收集 40例醫療不良事件以人為因素分類與分
析工具(HFACS)去系統性的挖掘每件案例發生錯誤之原因結果在行為層面中
分析結果主要為基礎技能錯誤(95)判斷和決策錯誤(875)其中在基礎技能
錯誤當中以未依程序作業執行(816)及未如預期設備操作(50)佔多數判斷和
決策錯誤中以現場風險評估不確實(686)及採取錯的步驟行為(686)佔多數
而在先決條件層面中以團隊合作(275)為主要因素包含溝通不良(818)及重
要訊息未以正確的方式即時傳達(727)佔多數在監督層面當中以監督不周
(929)或監督不妥當(929)為主要因素在組織政策和流程方面(50)以組織
系統的政策風險未充分評估(35)為主要因素結論本研究進一步了解醫療不
良事件在過去使用根本原因分析未探討到的人為因素反映出潛在的監督組織
行為或系統性的問題促進病人安全預防錯誤再發生
關鍵字病人安全醫療不良事件根本原因分析人為因素
1國泰醫療財團法人國泰綜合醫院 品質管理部
2國立臺灣大學健康政策與管理研究所
3振興醫療財團法人振興醫院 醫療品質管理中心
4輔仁大學醫學院
通訊作者王拔群 電子信箱 drtonyseednettw
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin 112
Submitted January 20 2020
Final version accepted April13
2020
Case Report
Juvenile Caruncular Atypical Lymphoid
Proliferation ndash A Rare Case Report
Cite as Hua-Wei Shih Yu-Chi Lin
Juvenile Caruncular Atypical
Lymphoid Proliferation ndash A Rare
Case Report Fu-Jen Journal of
Medicine 3(3) 112-119 2020
DOI
103966181020932020091803003
Hua-Wei Shih1 Yu-Chi Lin
1
1Department of Ophthalmology Shin Kong Wu Ho-Su Memorial Hos-
pital Taipei City Taiwan
Corresponding author E-mail address
yuchi067gmailcom (Yu-Chi Lin)
ABSTRACT
Lesions of the caruncle are very rare Most caruncular lesions are benign though there were still few reported malignant lesions Ocular adnexal lymphoproliferative disease (OALD) one of the differential diagnosis of caruncular lesion is seldom seen in young pa-tient In this article we report a 16-year-old boy with recurrent caruncular atypical lym-phoid proliferation We discuss the epidemiology clinical features images histomorpholo-gy and treatment between ocular adnexal lymphomas (OAL) and reactive lymphoid hyper-plasia (RLH)
Keywords caruncular lesion ocular adnexal lymphoproliferative disease ocular adnexal lymphoma
reactive lymphoid hyperplasia atypical lymphoid proliferation
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
113
INTRODUCTION Lesions of the caruncle are very rare Differen-
tial diagnosis includes nevus myeloproliferative
disorders tumors inflammation infection cysts
vascular lesions and fibrous Biopsy is essential
for diagnosis Levy J et al reported ocular ad-
nexal lymphoproliferative disease (OALD) was
relatively uncommon diagnosis among caruncu-
lar lesions [1]
OALD was seldom described in Asian popula-
tion especially for young age C-Y Cheng re-
ported age-standardized incidence of ocular
adnexal lymphomas (OAL) in Taiwan from 1979
to 1996 was below 07 per million per year and
mean age was 531 years old [2] In 2015 five
Taiwanese cases of OAL whose age ranging
from 45 to 64 were presented [3] However
there were few cases of conjunctival OAL or
RLH in Chinese pediatric patient
Here we present a case of 16-year-old boy with a
caruncular mass at his left eye with recurrence
one month after excision We describe his clini-
cal symptoms photographs pathological results
management and follow-up clinical course in
this report
CASE REPORT A 16-year-old healthy boy presented a mass
lesion at his left eye caruncle accompanied with
the symptom of tearing for one month (Figure 1)
He had no ocular pain no itchiness no blurred
vision no night sweating no fever and no body
weight loss The patient denied systemic diseas-
es and histories of surgery His bilateral best
corrected visual acuity (BCVA) were 66 and
intraocular pressure (IOP) were both within
normal range There were no remarkable find-
ings for his cornea lens fundus and physical
examination Excision was performed and the
mass was soft with fluid inside therefore con-
junctival pyogenic cyst was our initial diagnosis
However one month after the excision a pro-
truding mass recurred at the patientrsquos nasal can-
thus of left eye (Figure 2) There were some
differences compared to previous condition At
the first time the soft mass was contained in a
well-defined cyst wall which more favored py-
ogenic granulation However after short period
of recurrence solid consistency and unclear
margin were found which favored malignancy
Besides the mass partially involved beyond the
gray line of nasal part lower eyelid whereas last
time the cyst mainly extended from conjunctiva
of caruncle The second excisional biopsy was
performed Pathologic examination demonstrat-
ed abundant atypical lymphoid proliferation
(Figure 3A 3B) Immunohistochemical studies
showed that the lymphoid aggregation was
composed predominantly of CD20-positive cells
(Figure 3C) focal positive staining of CD3
(Figure 3D) CD5 CD23 CD10 and negative
staining of cyclin-D1 Unfortunately the cellular
morphology was difficult to be evaluated due to
marked crushing artifact Thus malignant lym-
phoma cannot be excluded totally
Orbital computed tomography (CT) showed a
lesion of soft tissue density at medial canthus of
left orbit without obvious nasolacrimal duct or
bony invasion (Figure 4A) Magnetic resonance
imaging (MRI) with contrast showed strong
enhancement at left medial canthus region (Fig-
ure 4B) There was no remarkable finding in the
systemic workup including complete blood
count and differential count biochemical pro-
files and 18F-fluoro-2-deoxyglucose positron
emission tomographycomputed tomography
(18F-FDG PETCT) indicating no evidence of
systemic involvement
After the second excision we preferred con-
servative management for him due to the uncer-
tainty of malignancy and to avoid side effects
from aggressive treatment No sign of recurrence
was noted after 10 months of observation The
follow-up photo was taken at three months after
the second operation (Figure 5)
DISCUSSION Ocular adnexal lymphoproliferative disease
(OALD) consists of the spectrum of lymphoid
disease affecting the tissues surrounding the eye
including ocular adnexal lymphomas (OAL) and
lymphoid hyperplasia (LH) [4] The conjunctiva
is an important location for extranodal lympho-
ma development which comprises 25 of OAL
[5]
OAL can be grouped into two categories based
on their appearance of cells under the micro-
scope low-grade and high-grade [6] Extranodal
marginal zone lymphoma of mucosa-associated
lymphoid tissue (EMZLMALT) is the most
common subtype of OAL followed by follicular
lymphoma [7-9] Both of the above are
low-grade lymphomas
LH can be further divided by histopathology into
reactive lymphoid hyperplasia (RLH) and atypi-
cal lymphoid hyperplasia (ALH) RLH has to-
tally benign morphology and immunophenotype
whereas ALH has borderline lesions between
RLH and lymphoma [10] OAL and LH are
mostly seen in patients with age between 50-70
years old There are rare cases in pediatric group
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
114
[71011] In the C-Y Chengrsquos statistical report of
OAL in Taiwan only 8 patients were younger
than 15 years old among the 101 cases of ocular
lymphoma [2] According to an US study inci-
dence rates of OAL were analyzed in different
age groups the group of age over 50 had the
highest incidence rate of 574 per million per-
son-years while the 0-19 age group had the
lowest incidence rate of 009 per million per-
son-years [12] The incidence of LH was even
less than OAL [13]
Patients with OALD may be asymptomatic or
with symptoms of proptosis eyelid swelling a
palpable painless mass or conjunctival salmon
patch Diplopia visual loss pain or inflamma-
tion occurred less frequently implying more
aggressive features [714]
Orbital LH is not distinguishable from low-grade
lymphoma radiologically They both typically
present a round or lobulated mass that diffusely
moderately enhances with contrast and usually
shows homogenous hypointense or isointense to
muscle barely invasion to bone or nervous sys-
tem [10] Atypical appearances including inho-
mogeneous calcification or bony changes may
be seen in high-grade lymphoma case reports
such as ocular adnexal diffuse large B-cell lym-
phoma (DLBCL) which is one of the more ag-
gressive type of OAL [7] Whole body PET is
used for not only the evaluation of systemic
involvement but also the standard for staging
lymphoma Our patientrsquos image studies revealed
neither obvious local invasion nor systemic ma-
lignancy indicating high-grade lymphoma was
less likely Low-grade lymphoma and benign
reactive lymphoid hyperplasia were still under
consideration
Histomorphology analysis and immunohisto-
chemistry (IHC) are essential for diagnosis
Flow cytometry and polymerase chain reaction
(PCR) technique are also applied to help differ-
entiate from RLH and OAL [1016] Our case
had immunohistochemical profile of positivity
for CD20 predominantly positivity focally for
CD3 CD5 CD10 CD23 and negativity for cy-
clin-D1 BCL-6 staining was not performed in
our casersquos biopsy Thus according to the IHC
report RLH ALH and follicular lymphoma are
probable diagnosis of our patient
Radiation therapy is the standard treatment for
low-grade OAL that is classified as T1N0M0 or
T2N0M0 according to the AJCC criteria [15]
İncesoy-Ouml zdemir S et al reported a 10-year-old
boy diagnosed of MALT lymphoma who was
treated with local radiotherapy (36 Gy) and
there were no local or systemic recurrences dur-
ing his nearly four-year follow-up [17] Another
case report represented a 21-year-old man of
conjunctival follicular lymphoma treated with
surgical excision only showing no evidence of
recurrence after 8 months follow-up [18] Other
treatment options for pediatric and juvenile OAL
were performed in some case reports including
intravenous rituximab intralesional interfer-
on-α-2b topical interferon a6 systemic doxycy-
cline surgical excision and postoperative local
cryotherapy [15]
Treatment for young conjunctival RLH was less
discussed in the past In a case series article
three children (9 13 14 years old respectively)
of RLH received surgical resection without fur-
ther postoperative management and no signs of
recurrence were noted during follow-up [19]
Short-term topical and oral corticosteroids after
surgical excision were prescribed in two pediat-
ric RLH patients for their small residual mass
However poor response in both cases was nota-
ble [20]
Our patient declined to receive radiotherapy or
any further postoperative treatment mainly due
to his concerning of possible side effects (such
as dry eye and cataract)
CONCLUSION We present a rare case of caruncle mass in this
report OALD is one of the relatively uncommon
diagnosis among caruncular lesions OALD
includes benign RLH and malignant OAL
which are both mainly seen in elderly patients
even rarer in pediatric or juvenile group
The standard treatment for low-grade OAL and
RLH in young patents are still debatable How-
ever long-term follow-up is suggested for both
OAL and RLH patients Though RLH has a be-
nign and self-limited course risk of malignant
transformation is possible
REFERENCES 1 Levy J Ilsar M Deckel Y et al Lesions of
the caruncle a description of 42 cases and
a review of the literature Eye
200923(5)1004-1018
2 C-Y Cheng and W-M Hsu Incidence of
eye cancer in Taiwan an 18-year review
Eye 200418152-158
3 Chui-Lien Tsen Muh-Chiou Lin
Youn-Shen Bee et al Ocular adnexal
lymphoma Five case reports and a
literature review Taiwan Journal of
Ophthalmology 20155(2)99-102
4 Liesegang TJ Ocular adnexal
lymphoproliferative lesions Mayo Clin
Proc 199368(10)1003-1010
5 Kirkegaard MM Coupland SE Prause JU
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
115
et al Malignant lymphoma of the
conjunctiva Surv Ophthalmol
201560(5)444-458
6 Stacy RC Jakobiec FA Schoenfield L et
al Unifocal and multifocal reactive
lymphoid hyperplasia vs follicular
lymphoma of the ocular adnexa Am J
Ophthalmol 2010150(3)412-426
7 Sullivan TJ Ocular Adnexal
Lymphoproliferative Disease In Guthoff
RF Katowitz JA eds Oculoplastics and
Orbit Berlin Heidelberg Springer
20101-19
8 White Valerie A Understanding and
Classification of Ocular Lymphomas
Ocular Oncology and Pathology
20195379-386
9 Stefanovic A Lossos IS Extranodal
marginal zone lymphoma of the ocular
adnexa Blood 2009114(3)501-510
10 Andrew NH Coupland SE Pirbhai A et al
Lymphoid hyperplasia of the orbit and
ocular adnexa A clinical pathologic review
Surv Ophthalmol 201661(6)778-790
11 Ferry JA1 Fung CY Zukerberg L et al
Lymphoma of the ocular adnexa A study
of 353 cases Am J Surg Pathol
200731(2)170-184
12 WM Hassan MS Bakry HM Hassan et al
Incidence of orbital conjunctival and
lacrimal gland malignant tumors in USA
from Surveillance Epidemiology and End
Results 1973-2009 Int J Ophthalmol
20169(12)1808-1813
13 Ajay A Rao John H Naheedy James Y-Y
Chen et al A Clinical Update and
Radiologic Review of Pediatric Orbital
and Ocular Tumors Journal of Oncology
2013(9)975908
14 Sullivan TJ Whitehead K Williamson R
et al Lymphoproliferative disease of the
ocular adnexa a clinical and pathologic
study with statistical analysis of 69
patients Ophthal Plast Reconstr Surg
200521177-188
15 Tanenbaum RE Galor A Dubovy SR et al
Classification diagnosis and management
of conjunctival lymphoma Eye Vis (Lond)
2019622
16 Olga Klavdianou Georgios Kondylis
Vasileios Georgopoulos et al Bilateral
benign reactive lymphoid hyperplasia of
the conjunctiva a case treated with oral
doxycycline and review of the literature
Eye Vis (Lond) 2019626
17 İncesoy-Ouml zdemir S Yuumlksek N Bozkurt C
et al A rare type of cancer in children
extranodal marginal zone B-cell (MALT)
lymphoma of the ocular adnexa Turk J
Pediatr 201456(3)295-298
18 Lynn J Poole Perry Frederick A Jakobiec
Peter A D Rubin Conjunctival Pediatric
Follicular Lymphoma Arch Ophthalmol
2012130(7)941-943
19 Abdullah Al-Mujaini Upender Wali
Anuradha Ganesh1 et al Ocular Adnexal
Reactive Lymphoid Hyperplasia in
Children Middle East Afr J Ophthalmol
201219(4)406-409
20 McLeod SD Edward DP Benign
lymphoid hyperplasia of the conjunctiva in
children Arch Ophthalmol
1999117(6)832-835
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
116
FIGURES
Figure 1 Slit lamp image of a mass lesion at the patientrsquos left eye caruncle for one month
Figure 2 One month after the first excision a protruding mass recurred at the patientrsquos nasal canthus
of left eye It partially involved beyond the gray line of nasal part lower eyelid
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
117
Figure 3 Histomorphology analysis and immunohistochemistry study of the caruncular lesion Abun-
dant atypical lymphoid proliferation presented in low-power photomicrograph (A) and
high-power photomicrograph (B) under hematoxylin-eosin staining The lymphoid aggrega-
tion was composed predominantly of CD20-positive cells (C) and focal positive staining of
CD3 (D)
Figure 4 Non-contrast orbital computed tomography showed a lesion of soft tissue density at medial
canthus of left orbit without obvious nasolacrimal duct or bony invasion (A) Magnetic reso-
nance imaging with contrast showed strong enhancement at left medial canthus region (B)
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
118
Figure 5 The follow-up photo were taken at three months after the second excision showing no signs
of recurrence
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
119
Juvenile Caruncular Atypical Lymphoid Proliferation ndash A Rare Case Report
罕見病例報告mdash青少年之淚阜非典型淋巴增生
施驊瑋 1林友祺 1
中文摘要
淚阜病灶相當罕見大部分為良性病灶眼睛及附屬結構淋巴增生疾病為其
鑑別診斷之一非常少見於年輕人或兒童我們報告一位 16歲的健康男性因
左眼淚阜無痛性腫塊接受切除手術卻於術後一個月復發執行第二次切除手術
後門診追蹤十個月未再復發此案例表現了部分良性與部分惡性腫瘤的特徵
我們針對反應性淋巴增生眼睛及附屬結構淋巴癌兩個疾病做討論及文獻回顧
關鍵字淚阜病灶眼睛及附屬結構淋巴增生疾病眼睛及附屬結構淋巴癌反
應性淋巴增生非典型淋巴增生
1 新光吳火獅紀念醫院眼科
通訊作者林友祺 電子信箱 yuchi067gmailcom
Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh 120
Submitted March 26 2020
Final version accepted April 16
2020
Case Report
Hyperacute intramembranous hemor-
rhage after burr hole craniostomy for
chronic subdural hematoma
Cite as Meng-Chi Lin Jui-Ming
Sun Yu-Hao Chen Cheng-Ta
Hsieh
Hyperacute intramembranous
hemorrhage after burr hole crani-
ostomy for chronic subdural he-
matoma Fu-Jen Journal of Medi-
cine 3(4) 120-125 2020
DOI
103966181020932020091803004
Meng-Chi Lin1 Jui-Ming Sun23 Yu-Hao Chen24 Cheng-Ta
Hsieh567
1Department of Surgery Zuoying Branch Kaohsiung Armed Forces
General Hospital Kaohsiung 813 Taiwan 2Section of Neurosurgery Department of Surgery Chia-Yi Christian
Hospital Chia-Yi City 600 Taiwan 3Department of Biotechnology Asia University Taichung City 41354
Taiwan 4Chung-Jen Junior College of Nursing Health Sciences and Manage-
ment Chia-Yi Country 62241 Taiwan 5Division of Neurosurgery Department of Surgery Sijhih Cathay Gen-
eral Hospital New Taipei City 22174 Taiwan 6Department of Medicine School of Medicine Fu Jen Catholic Univer-
sity New Taipei City 24205 Taiwan 7Department of Neurological Surgery Tri-Service General Hospital
National Defense Medical Center Taipei 114 Taiwan
Corresponding author E-mail address
nogormail2000comtw (Cheng-Ta Hsieh)
ABSTRACT
Burr hole craniostomy with closed-system drainage is an effective and common neurosurgical procedure to manage chronic subdural hematoma Postoperative hem-orrhage a well-known but infrequent complication may result in increased neurolog-ical deficits However hyperacute intramembranous hemorrhage within the inner and outer membrane of hematoma after burr hole craniostomy with irrigation and closed-system drainage has not been described previously Herein we report a case of postoperative spontaneous hyperacute intramembranous hemorrhage after burr hole craniostomy with closed-system drainage to manage a chronic subdural hematoma we subsequently discuss the possible pathophysiological mechanisms and review the relevant literature
Keywords Chronic subdural hematoma acute subdural hematoma bleeding burr hole craniostomy
drainage
Fu-J
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Vol 3 No 4 2
Acute intram
Yu-Hao Chen
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outer and ievidence suggwith or wite and widely ut and that it ] Recurrence r this surgerywever the hyng after burr ely been discucase of a pa
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ISCUSSIO61-year-old won without regd been takingning Ganodermrs She was tment when shurological exasgow Coma S
muscle strengs was 45 on
ale Her laborh the normal rnoted Brain
n revealed Ch a marked m
ently she receniostomy withinage ring surgery mthe subdural sn of the duramatoma The arile saline throsed drainage swever this inm the subduraealed a hyperdural space fniostomy siteniotomy withthe hematom
morrhage was d inner membgure 3) No aface was obseealed an organn of fibroblasne Postoperaogical deficits
EFERENCRohde VComplicatiand closedsubdural analysis of
active bleedinerved Histolonized hematots and capilla
ative recoverywas gradual a
ON oman had a hi
gular medicatig nutritional ma lucidum referred to ohe became proxamination rScale ratings wgth score in th
the Medical ratory examinranges with nn computed
CSDH in the midline shift (ived one righth irrigation a
motor oilndashlikespace was uncal and outer marea was irrigaough the subdusystem was plcreased the rel space An emracute hemorrfrom the frone (Figure 2B
membranectma was perfo
only observebrane of theactive bleedinerved Histolonized hematots and capilla
ative recoverywas gradual a
CES V Graf Gons of burr-
d-system draihematomas
f 376 patient
ng from the ogical examinoma with prolaries in the m
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history of hypeion treatmentsupplements for more tha
our emergencyogressively drrevealed thatwere E1M5V2he left side ex
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(Figure 1) St parietal burrand closed-sy
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Vol 3 No 4 2
Acute intram
Yu-Hao Chen
vealing a layer
displaying a m
quent CT scan
em drainage (
rhage in the ri
2020
membranous
Cheng-Ta Hs
red type of CS
midline shift
ns (A) Bone w
(white arrow)
ight frontal re
hemorrhage
ieh
SDH (white ar
window view
and (B) Soft
gion (white ar
rrow) in the rig
showed the b
tissue windo
rrow)
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burr hole crani
ow showed hy
123
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Fu-J
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g-Chi Lin Ju
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of Medicine V
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Vol 3 No 4 2
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Yu-Hao Chen
o revealing ac
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cute intramem
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124
mem-
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Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh
125
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
慢性硬腦膜下出血進行鑽顱引流手術造成超急性夾膜內出
血
林孟楫 1孫瑞明 23陳昱豪 24謝政達 567
中文摘要
鑽顱併封閉系統引流手術是治療慢性硬腦膜下出血患者一種有效且常見的
神經外科手術方式術後出血可能導致神經功能缺損惡化是眾所周知但不常見
的併發症之一然而至今仍未有鑽孔併封閉系統引流造成原本慢性硬腦膜血
塊內膜和外膜間急性夾膜間出血案例在這裡我們報告一例慢性硬腦膜下出
血病患者接受鑽顱併封閉系統引流手術治療造成術後急性夾膜間出血我們在
本文中討論可能的致病機制並回顧相關文獻
關鍵字慢性硬腦膜下出血急性硬腦膜下出血出血鑽顱術引流
1國軍高雄總醫院左營分院 外科部
2崇仁醫護管理專科學校
3亞洲大學 生物科技學系
4戴德森醫療財團法人嘉義基督教醫院 外科部 神經外科
5汐止國泰綜合醫院 神經外科
6輔仁大學 醫學系
7 國防醫學院 三軍總醫院 神經外科
通訊作者謝政達 電子信箱 nogormail2000comtw
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
126
Submitted January 21 2020
Final version accepted July 08
2020
Case Report
Hamartoma of the breast A case report
Cite as Hsuan-An Chen
Cheng-Yu Lo Shih-Hung Huang
Chin-Lung Lin
Hamartoma of the breast A case
report Fu-Jen Journal of Medicine
3(5) 126-130 2020
DOI
103966181020932020091803005
Hsuan-An Chen1 Cheng-Yu Lo
3 Shih-Hung Huang
3 Chin-Lung
Lin2
1Department of Surgery Cathay General Hospital Taipei Taiwan
2Department of General Surgery Cathay General Hospital Taipei Tai-
wan
3Department of Pathology Cathay General Hospital Taipei Taiwan
Corresponding author E-mail address
lungyungmailcom (Chin-Lung Lin)
ABSTRACT
Breast hamartoma is an uncommon benign tumor rarely associated with malignancy An
excision and histological examination is necessary for the differential diagnosis We report
a case of a 49-year-old female patient presenting with a lump in the right breast Ultrasound
examination which demonstrated a 4411 cm hypoechoic lesion with lipoma Partial mas-
tectomy was arranged and the diagnosis of a hamartoma was confirmed by the histological
examination
Keywords Breast tumor Hamartoma Ultrasound
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
127
INTRODUCTION The hamartoma is a benign tumor-like lesion
that can affect various organs of the body in-
cluding lungs kidneys skin and more rarely the
breast In 1981 the hamartomas were recognized
in the WHO classification[1] They are defined
as well-demarcated mass of mammary ducts and
lobules containing varying amounts of fibrous
and adipose tissue and producing a distinctive
mammographic image
CASE REPORT A 49 year-old female had past history of left
breast mastitis with abscess status post partial
mastectomy This time she presented to our out
patient clinic for breast examination Physical
examination revealed a painless palpable mova-
ble and painless lump at upper outer quadrant of
right breast The risk of breast cancer was not
noted and the patient did not have any family
history of breast cancer The patient also denied
any trauma history before Ultrasound examina-
tion was arranged which demonstrated a 4411
cm hypoechoic lesion with lipoma at 3 oclock 2
cm from nipple of right breast and multiple hy-
poechoic nodules of various size in both breasts
and there was no suspicious axillary lymph
nodes noted (Figure1) Surgical treatment was
arranged partial mastectomy of right breast
harmartoma was successfully performed A 32 x
31 x 21 cm tumor was completely excised
Grossly examination showed a gray to yellow
and firm to fatty The diagnosis of a hamartoma
was confirmed by the histological examination
Microscopically sections of the breast lesion
show mammary hamartoma composed of ducts
lobules with interlobular fibrous tissue and adi-
pose tissue Fibrocystic change apocrine meta-
plastic ducts and scattered foci of adenosis are
noted The overall lobulocentric architecture and
the 2-cell pattern of the epithelium are preserved
columnar cell change and focal microcalcifica-
tion are present (Figure2) Based on submitted
biopsy specimen in-situ or invasive tumor cells
are not identified
DISCUSSION Hamartoma of the breast is a benign tumor like
nodule it was also known as fibroadenolipoma
lipofibroadenoma or adenolipoma based on its
predominant components It was composed of
varying amounts of glandular adipose and fi-
brous tissue[2] Hamartomas were first described
in 1971 by Arrigoni et al in a study of 10 patients
which breast tumors clinically and grossly re-
sembled fibroadenomas[3]
A higher predominance of tumors exists in fe-
males compared with males Hamartomas are
slowly-growing lesions with the diameter rang-
ing from 2 cm to 5 cm sometimes hamartomas
can reach giant diameter [4]
The clinical diagnosis of hamartoma is based on
the findings from mammography sonography
and histology examinations The hamartomas are
usually incidentally diagnosed by the women
older than 40 year-old starting mammography
screening
On physicial examination harmatomas are usu-
ally occult painless they may be as large mo-
bile soft to firm masses[5] Ultrasound showed
well capsulated mass with echogenic rim and
internal heterogeneity Mammography exam
showed well-circumscribed round to oval
masses containing fat and soft tissue densities
with a thin radiopaque pseudocapsule The
pseudocapsule results from displacement of
breast parenchyma by the tumor [56] In Pa-
thology finding microglandular adenosis is pre-
sent in fibroadipose stroma surrounded by a thin
fibrous capsule It composed of a combination of
epithelial and stromal elements usually with
normal ducts or lobules although variations of
normal tissue may also be seen Fibroadenoli-
poma myoid hamartoma and chondrolipoma are
histological variations of hamartomas depend-
ing on the proportion of normal breast tissue
elements[7]
Malignancy associated with hamartomas are
very rare[8] However it has been reported
hamartomas develop into carcinoma Malignant
transformation can occur as a result of cellular
atypia in the epithelial component of the mass[9]
Surgical removal is the curative method for
breast hamartomas[10] Diagnostic material such
as mammography ultrasonography or core nee-
dle biopsy may not give the definitive diagnosis
Therefore surgical excision and histological
examination is necessary for differential diagno-
sis[111213]
Although it is rare hamartoma can be seen along
with malignancy as it is formed from similar
components of breast tissue Therefore careful
diagnosis and appropriate management including
surgery are required
REFERENCES 1 World Health Organization (1981)
Histological typing of breast tumors In
International histological classification of
tumors 1981 2nd ed
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
128
2 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11435ndash449
2006
3 ArrigoniMG DockertyMB JuddES
The identificationand treatment of
mammary hamartoma Surg Gynecol
Obstet1971 133 577-82
4 Sanal HT Ersoz N Altinel O Unal E Can
C Giant hamartoma of the breast Breast J
2006 12 84-85
5 Feder JM de Paredes ES Hogge JP
Wilken JJ Unusual breast lesions
radiologic-pathologic correlation
Radiographics 1999 19S11ndashS26
6 Murat A Ozdemir H Yildirim H Poyraz
AK Ozercan R Hamartoma of the breast
Australas Radiol 200751 Spec NoB37ndash
9
7 Fisher CJ Hanby AM Robinson L Millis
RR Mammary hamartoma-a review of 35
cases Histopathology 1992 20 99-106
8 Choi N Ko ES Invasive ductal carcinoma
in a mammary hamartoma case report and
review of the literature Korean J Radiol
2010 Nov-Dec11(6)687-91
9 Lee EH Wylie EJ Bourke AG Bastiaan
De Boer W Invasive ductal carcinoma
arising in a breast hamartoma two case
reports and a review of the literature Clin
Radiol 2003 58 80-3
10 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11 435 ‑449
2006
11 Coyne J Hobbs FM Boggis C Harland R
Lobular carcinoma in a mammary
hamartoma J Clin Pathol 199245936ndash
937
12 G M K Tse B K B Law T K F Ma A B W
Chan Hamartoma of the breast a
clinicopathological review J Clin Pathol
200255951ndash954
13 RAAmir SSheikh BreasthamartomaA
report of 14cases of an under-recognized
and under-reported entity International
Journal of Surgery Case Reports
22(2016)1ndash4
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
129
FIGURES
Figure 1 Ultrasound shows a 4411 cm hypoechoic lesion with lipoma at 3 oclock 2 cm from nipple
of right breast
Figure 2 Photomicrograph shows mammary hamartoma composed of ducts lobules with interlobular
fibrous tissue and adipose tissue
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
130
Hamartoma of the breast A case report
乳房錯構瘤罕見個案報告
陳宣安 1羅承裕 3黃世鴻 3林錦龍 2
中文摘要
乳房錯構瘤是一種罕見之乳房良性腫瘤切除手術及病理化驗來做鑑別診斷
我們報告一位 49歲女性以可觸摸到無痛性右側乳房腫塊為臨床表徵超音波
看到一個邊緣清楚低迴音的腫塊病患接受手術切除病灶病理診斷證實為乳
房錯構瘤
關鍵字乳房腫瘤錯構瘤超音波攝影
1國泰綜合醫院外科部
2國泰綜合醫院一般外科
3國泰綜合醫院病理科
通訊作者林錦龍 電子信箱 lungyungmailcom
Fu-Jen Journal of Medicine
Mission and Goals
The Fu-Jen Journal of Medicine (FJJM) is a peer-reviewed journal which
aims to enhance research quality of staffs in the College of Medicine Fu Jen
Catholic University The journal publishes original investigations across a
wide range of medical disciplines including original research articles in basic
and clinical sciences case reports review articles brief reports and letter
to the editor FJJM is now issued by the Center of Medical Education in the
College of Medicine Fu Jen Catholic University To promote journal quality
the manuscript submitted to FJJM after August first 2015 has to be prepared
in English to meet the international standards
Issue Date
Publication Date
Institution
December 01 2003
September 30 2020
College of Medicine Fu Jen Catholic University
Honorable publisher Han-Sun Chiang
Publisher Ping-Keung Yip
Editor-in-chief Ming-Chieh Ma
Associate Editors Yu-Wen Lin
Editors
Telephone (02) 2905-3477
Address Center for Medical Education College of Medicine Fu Jen
Catholic University
No 510 Zhongzheng Rd Xinzhuang Dist New Taipei City
24205 Taiwan
Su-Jane Wang Chi-Chung Wang Chih-Ming Ho
Yih-Jing Lee Chih-Shung Wong Tze-Wah Kao
Chi-Feng Hung Rung-Fen Feng Chee-Fah Chogn
Chia-Chen Lu Zai-Ting Yeh
Dee Pei Chih-Kuang Liu
Hen-Hui Lien Chien-Hsiou Liu
Chun-Hou Liao Yi-Ju Tsai Sheng-Wen Teng
Chia-Ting Su
- 9月封面
- 9月目錄頁
- 2020九月刊排版NO1_完稿
- 2020九月刊排版NO2_完稿
- 2020九月刊排版NO3_完稿
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- 版權頁(SEP)
- 9月封底
-
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 102
framework exists for investigation
cross-institution variability and interrater relia-
bility are often ignored 2) Conclusions are often
subjective and corrective recommendations are
less actionable relying on individual reviewersrsquo
professional backgrounds and their experiences
3) Much focus on event reconstruction and oper-
ator performance means that factors relating to
human behavior organizational culture and
system weakness are not comprehensively ad-
dressed [671718] Traditionally attempts to
improve patient safety in the health care industry
are largely reactive in nature identifying and
correcting errors in care processes [1920]
Causes of defects are not thoroughly understood
Proactive approaches must be taken to address
systematic problems within a complex system
[720] Research suggests that human error is a
causal factor in the occurrence of AMEs AME
investigation targets have moved from skill defi-
ciency toward decision-making attitudes super-
visory factors and even organizational climate
or culture HFACS methodology is based on the
Swiss cheese model that also emphasizes active
and latent failures [921] The study provides
some noteworthy findings First most AMEs as
expected involve active failures such as failure
to follow procedure accidental operation of
equipment inadequate real-time risk manage-
ment and inappropriate action These are all
sharp ends in classic RCA environment physi-
cal and mental factors are less prevalent This
proves that retrospectively determining addi-
tional causal factors is difficult when infor-
mation has not been collected during preliminary
investigation (Figure 1) Second team-
work-related problems particularly in relation to
communication and information relay are well
addressed This may be attributed to the dec-
ade-long institution-wide routine crew resource
management training in the respective research
hospital (Figure 2) Third the HFACS success-
fully reflects the importance of supervisory roles
in the occurrence of AMEs and this cannot be
overlooked (Figure 3) Fourth latent failures
especially in organizational climate or cultural
dimensions have been less frequently addressed
in incident reports a limitation of traditional
RCA However the HFACS review suggests
room for improvement in resource allocation and
policy modification within the hospital The
results of studies can make the organization
think about how to improve the patient safety
and management process from the perspective of
human factors such as improving the comfort of
the working environment and replacing and
equipment resources to prevent personnel from
affecting the medical quality and patient safety
due to the environment or equipment Need to
appropriate assessment of applicability and ade-
quate training of manpower is required The
management and control of risks should be fully
evaluate and grasp resource management and
leaders need to participate in and promote medi-
cal quality and patient safety activities to en-
hance its culture (Figure 4) No panacea exists
to ensure patient safety and improvement targets
originate largely from event investigation find-
ings Unfortunately factors identified from
AMEs are often self-explanatory with little value
for further action correction Reinforcement of
policy or processes redundant education or
repetitious training are formulaic overprescribed
RCA recommendations The use of HFACS in
this study proves that a structural prospective
AME investigation format can potentially help
with proactive patient safety management We
suggest developing an interview guideline for
the routine use of HFACS as a complement to
RCA in every AME investigation This study is a
retrospective study The underlying human fac-
tors can be under-estimated owing to the lack of
related information in the original RCA reports
CONCLUSION The HFACS review in this study enhances our
understanding of human factors in AMEs that
had previously been insufficiently scrutinized
Aside from active process and communication
errors the HFACS enables the prospective in-
vestigation of latent supervisory organizational
or systematic problems that cannot be addressed
through traditional RCA
REFERENCES 1 T Brennan L Leape N Laird et al
Incidence of adverse events and
negligence in hospitalized patients results
of the Harvard Medical Practice Study I N
Engl J Med 1991324370-376
2 Wang CH Shih CL Chen WJ et al
Epidemiology of medical adverse events
perspectives from a single institute in
Taiwan J Formos Med Assoc
2016115434-439
3 Vincent C Simon R Sutcliffe K et al
Errors Conference Executive Summary
Acad Emerg Med 200071180-1182
4 Taitz J Genn K Brooks V et al
System-wide learning from root cause
analysis A report from the New South
Wales Root Cause Analysis Review
Committee Qual Saf Health Care
2010191-5
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 103
5 Hutchinson A Young TA Cooper KL et
al Trends in healthcare incident reporting
and relationship to safety and quality data
in acute hospitals results from the
National Reporting and Learning System
Qual Saf Health Care 2009185-10
6 Mitchell RJ Williamson AM Molesworth
B et al A review of the use of human
factors classification frameworks that
identify causal factors for adverse events
in the hospital setting Ergonomics
2014571443-1472
7 Gurses AP Ozok AA Pronovost PJ Time
to accelerate integration of human factors
and ergonomics in patient safety BMJ
Qual Saf 201221347-351
8 Health and Safety Executive Introduction
to human factors
httpwwwhsegovukhumanfactorsintro
ductionhtm
9 Wiegmann DA Shappell SA A human
error approach to aviation accident
analysis The human factors analysis and
classification system Burlington VT
Ashgate Publishing Ltd 2003
10 Yu-Hsun Cheng Sheng-Hui Hung
Tung-Wen Ko et al An Analysis of the
Reliability and Validity of Human Factors
Analysis Classification System in Medical
Adverse Events Journal of Healthcare
Quality 20191370-76
11 Taiwan Joint Commission on Hospital
Accreditation Taiwan Patient-Safety
Reporting System Annual Report 2017
New Taipei City Taiwan
12 Taiwan Patient Safety Net
httpwwwpatientsafetymohwgovtwCo
ntentzMessagesslistaspxSiteID=1ampMm
mID=621273300317401756
13 Government of Western Australia
Department of Health
httpsww2healthwagovauArticlesS_T
Severity-assessment-codes
14 Farley DO Haviland A Champagne S et
al Adverse-event-reporting practices by
US hospitals results of a national survey
Qual Saf Health Care 200817416-423
15 Shojania KG Thomas EJ Trends in
adverse events over time why are we not
improving BMJ Qual Saf
201322273-277
16 Levitt P Challenging the systems approach
why adverse event rates are not improving
BMJ Qual Saf 2014231051-1052
17 Kellogg KM Hettinger Z Shah M et al
Our current approach to root cause
analysis is it contributing to our failure to
improve patient safety BMJ Qual Saf
201726381-387
18 Khorsandi M Skouras C Beatson K et al
Quality review of an adverse incident
reporting system and root cause analysis of
serious adverse surgical incidents in a
teaching hospital of Scotland Patient Saf
Surg 2012621
19 Diller T Helmrich G Dunning S et al
The Human Factors Analysis
Classification System (HFACS) Applied to
Health Care Am J Med Qual
201429181-190
20 Carayon P Xie A Kianfar S Human
factors and ergonomics as a patient safety
practice BMJ Qual Saf 201423196-205
21 Reason J Human Error New York
Cambridge University Press 1990
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 104
TABLE
Table 1 Incidences by Category (N=40)
CategorySAC SAC 4 SAC 3 SAC 2 SAC 1 total
Laboratory and ex-
amination events
4 10 2 0 16 (400)
Clinical care event 6 2 1 0 9 (225)
Medication event 5 0 2 0 7 (175)
Surgery-related event 1 1 2 0 4 (100)
Transfusion-related
event
1 1 0 0 2 (50)
Tube event 0 1 0 0 1 (25)
Public accident 0 0 1 0 1 (26)
Total 17 (425) 15 (375) 8 (200) 0 40 (100)
SAC 1113 Severity Assessment Code SAC
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 105
FIGURES
Figure 1 Active Failures (N=40)
16 (167)
66 (1000)
640 (150)
235 (57)
735 (200)
2435 (686)
2435 (686)
3540 (875)
438 (105)
438 (105)
738 (184)
1938 (500)
3138 (816)
3840 (950)
0 5 10 15 20 25 30 35 40
Commits WidespreadRoutine Violation
Performs Work-Around Violation
Ignored a CautionWarning
Failure to Prioritize Tasks Adequately
Wrong Choice of Action During an Operation
Inadequate Real‐Time Risk Assessment
Rushed or Delayed a Necessary Action
Breakdown in Visual Scan
Over-ControlledUnder-Controlled AircraftVehicleSystem
Unintended Operation of Equipment
Procedure Not Followed Correctly
Performance-Based Errors
Judgment and Decision Making Errors
Violations
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 106
Figure 2 Preconditions (Latent Failures or Conditions) (N=40)
14 (250)
24 (500)
48 (500)
11 (1000)
18 (125)
840 (200)
0 5 10 15 20 25 30 35 40
Seat and Restraint System Problems
Instrumentation amp Warning System Issues
Noise Interference
Environment
Physical Environment
Technological Environment
27 (286)
27 (286)
27 (286)
37 (129)
47 (511)
47 (571)
77 (1000)
24 (500)
44 (1000)
47 (571)
12 (500)
22 (1000)
27 (286)
740 (175)
0 5 10 15 20 25 30 35 40
Technical or Procedural Knowledge Not Retained After Training
InterferenceInterruption
Task OverUnder Saturation
Distraction
Negative Habit Transfer
Not Paying Attention
Complacency
Overconfidence
Physical IllnessInjury
Fatigue
Physical and Mental State
Physical Problem
State of Mind
Mental Awareness
211 (182)
311 (273)
311 (273)
411 (364)
811 (7227)
911 (818)
1140 (275)
0 5 10 15 20 25 30 35 40
Inadequate Task Delegation
TaskMission PlanningBriefingDebriefing Inadequate
Failure of CrewTeam Leadership
StandardProper Terminology Not Used
Critical Information Not Communicated
Failed to Effectively Communicate
Teamwork
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 107
Figure 3 Supervision (Direct Supervisory Chain of Command) (N=40)
Figure 4 Organization Influence (Upper-Level Management Command Level) (N=40)
114 (71)
114 (71)
214 (143)
314 (214)
1314 (929)
1440 (350)
511 (455)
511 (455)
711 (636)
1140 (275)
47 (571)
67 (857)
740 (175)
0 5 10 15 20 25 30 35 40
Selected Individual with Lack of Proficiency
Improper Role‐modeling
Failed to Provide Proper Training
Failed to IdentifyCorrect Risky or Unsafe Practices
SupervisoryCommand Oversight Inadequate
Performed Inadequate Risk Assessment ‐Formal
Selected Individual with Lack of Current or Limited Experience
Authorized Unnecessary Hazard
Allowing Unwritten Policies to Become Standard
Failure to Enforce Existing Rules
Supervisory Violations
Planned Inappropriate Operations
Inadequate Supervision
12 (500)
12 (500)
240 (50)
110 (100)
510 (500)
1040 (250)
11 (1000)
140 (25)
18 (125)
18 (125)
38 (35)
48 (500)
840 (200)
0 5 10 15 20 25 30 35 40
Organizational Over-confidence or Under-confidence in Equipment
Organizational Culture (attitude actions) Allows for Unsafe TaskMission
Purchasing or Providing Poorly Designed or Unsuitable Equipment
Organizational ProgramPolicy Risks not Adequately Assessed
Failure to Provide Adequate Manning Staffing Resources
Failure to remove inadequate worn-out equipment in timely manner
Inadequate infrastructure
Command and control resources are deficient
Failure to provide adequate operational information resources
Resource Problems
Personnel Selection amp Staffing
Policy and Process Issues
ClimateCulture Influences
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 108
Supplement Table 1- HFACS Content of Human Factor Analysis Classifi-
cation System [9] Tier main level sub-item nano code
Tier 1 Unsafe Acts
Perfor-
mance-Based
Errors
Unintended operation of equipment
Checklist not followed correctly
Procedure not followed correctly
Over-controlledunder-controlled aircraftvehiclesystem
Breakdown in visual scan
Rushed or delayed a necessary action
Judgment amp De-
cision-Making
Errors
Inadequate real‐time risk assessment
Failure to prioritize tasks adequately
Ignored a cautionwarning
Wrong choice of action during an operation
Violations
Performs work-around violation
Commits widespreadroutine violation
Extreme violation-lack of discipline
Tier 2 Preconditions
Environment
Physical environment
Environmental conditions affecting vision
Vibration effects vision or balance
Heatcold stress impairs performance
External force of object impeded an individualrsquos
movement
Lights of other vehiclevesselaircraft affected vision
Noise interference
Technological environment
Seat and restraint system problems
Instrumentation amp warning system issues
Visibility restrictions (not weather related)
Controls and switches are inadequate
Automated system creates unsafe situation
Workspace incompatible with operation
Personal equipment interference
Communication equipment inadequate
Physical and
Mental State
Physical problem
Substance effects (alcohol supplements medications
drugs)
Loss of consciousness (sudden or prolonged onset)
Physical illnessinjury
Fatigue
Inadequate adaptation to darkness
Dehydration
Body sizemovement limitations
Physical strength amp coordination (inappropriate for
task demands)
Nutritiondiet
State of mind
Psychological problem
Life stressors
Emotional state
Personality style
Overconfidence
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 109
Pressing
Complacency
Motivation
Motivational exhaustion (burnout)
Sensory misperception
Motion illusion-kinesthetic
Turning illusionbalance-vestibular
Visual illusion
Misperception of changing environment
Misinterpreted misread instrument
Misinterpretation of auditorysound cues
Spatial disorientation
Temporaltime distortion
Mental awareness
Not paying attention
Fixation
Task overunder saturation
Confusion
Negative habit transfer
Distraction
Geographically lost
Interferenceinterruption
Technical or procedural knowledge not retained after
training
Inaccurate expectation
Teamwork
Failure of crewteam leadership
Inadequate task delegation
Rankposition intimidation
Lack of assertiveness
Critical information not communicated
Standardproper terminology not used
Failed to effectively communicate
Taskmission planningbriefingdebriefing inadequate
Tier 3 Supervision
Supervisory Vio-
lations
Failure to enforce existing rules
Allowing unwritten policies to become standard
Directed individual to violate existing regulations
Authorized unqualified individuals for task
Planned Inappro-
priate Operations
Directed task beyond personnel capabilities
Inappropriate team composition
Selected individual with lack of current or limited experience
Performed inadequate risk assessment ‐formal
Authorized unnecessary hazard
Inadequate Su-
pervision
Supervisorycommand oversight inadequate
Improper role‐modeling
Failed to provide proper training
Failed to provide appropriate policyguidance
Personality conflict with supervisor
Lack of supervisory responses to critical information
Failed to identifycorrect risky or unsafe practices
Selected individual with lack of proficiency
Tier 4 Organizational
Influences
Resource Prob-
lems
Command and control resources are deficient
Inadequate infrastructure
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 110
Failure to remove inadequate worn-out equipment in timely
manner
Failure to provide adequate operational information resources
Fail to provide adequate funding
Personnel Selec-
tion amp Staffing
Personnel recruiting amp selection policies are inadequate
Failure to provide adequate manning staffing resources
Policy amp Process
Issues
Pace of ops-tempoworkload
Organizational programpolicy risks not adequately assessed
Provided inadequate procedural guidance or publications
Organizational (formal) training is inadequate or unavailable
Flawed doctrinephilosophy
Inadequate program management
Purchasing or providing poorly designed or unsuitable equip-
ment
ClimateCulture
Influences
Organizational culture (attitude actions) allows for unsafe
taskmission
Organizational over-confidence or under-confidence in equip-
ment
Unit missionaircraftvehicleequipment change or unit deacti-
vation
Organizational structure is unclear or inadequate
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 111
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
以 HFACS重新檢視根本原因分析案例挖掘造成醫療不良
事件之人為因素
鄭伃洵 1洪聖惠 12柯彤文 3王拔群 14
中文摘要
背景醫療不良事件(AMEs)的管理是促進病人安全的基石根本原因分析
(RCA)是探討重大病人安全不良事件問題但是由於無法解釋更廣泛的因素而受
到限制本研究使用人為因素分類與分析工具(HFACS)回溯審視醫療不良事件
以了解影響醫療不良事件的人為因素及各層面中錯誤原因之分佈或系統性問題
方法本研究回溯 2012-2016年間有做過根本原因分析之醫療不良事件以連續
性取樣方式(continuous sampling)收集 40例醫療不良事件以人為因素分類與分
析工具(HFACS)去系統性的挖掘每件案例發生錯誤之原因結果在行為層面中
分析結果主要為基礎技能錯誤(95)判斷和決策錯誤(875)其中在基礎技能
錯誤當中以未依程序作業執行(816)及未如預期設備操作(50)佔多數判斷和
決策錯誤中以現場風險評估不確實(686)及採取錯的步驟行為(686)佔多數
而在先決條件層面中以團隊合作(275)為主要因素包含溝通不良(818)及重
要訊息未以正確的方式即時傳達(727)佔多數在監督層面當中以監督不周
(929)或監督不妥當(929)為主要因素在組織政策和流程方面(50)以組織
系統的政策風險未充分評估(35)為主要因素結論本研究進一步了解醫療不
良事件在過去使用根本原因分析未探討到的人為因素反映出潛在的監督組織
行為或系統性的問題促進病人安全預防錯誤再發生
關鍵字病人安全醫療不良事件根本原因分析人為因素
1國泰醫療財團法人國泰綜合醫院 品質管理部
2國立臺灣大學健康政策與管理研究所
3振興醫療財團法人振興醫院 醫療品質管理中心
4輔仁大學醫學院
通訊作者王拔群 電子信箱 drtonyseednettw
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin 112
Submitted January 20 2020
Final version accepted April13
2020
Case Report
Juvenile Caruncular Atypical Lymphoid
Proliferation ndash A Rare Case Report
Cite as Hua-Wei Shih Yu-Chi Lin
Juvenile Caruncular Atypical
Lymphoid Proliferation ndash A Rare
Case Report Fu-Jen Journal of
Medicine 3(3) 112-119 2020
DOI
103966181020932020091803003
Hua-Wei Shih1 Yu-Chi Lin
1
1Department of Ophthalmology Shin Kong Wu Ho-Su Memorial Hos-
pital Taipei City Taiwan
Corresponding author E-mail address
yuchi067gmailcom (Yu-Chi Lin)
ABSTRACT
Lesions of the caruncle are very rare Most caruncular lesions are benign though there were still few reported malignant lesions Ocular adnexal lymphoproliferative disease (OALD) one of the differential diagnosis of caruncular lesion is seldom seen in young pa-tient In this article we report a 16-year-old boy with recurrent caruncular atypical lym-phoid proliferation We discuss the epidemiology clinical features images histomorpholo-gy and treatment between ocular adnexal lymphomas (OAL) and reactive lymphoid hyper-plasia (RLH)
Keywords caruncular lesion ocular adnexal lymphoproliferative disease ocular adnexal lymphoma
reactive lymphoid hyperplasia atypical lymphoid proliferation
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
113
INTRODUCTION Lesions of the caruncle are very rare Differen-
tial diagnosis includes nevus myeloproliferative
disorders tumors inflammation infection cysts
vascular lesions and fibrous Biopsy is essential
for diagnosis Levy J et al reported ocular ad-
nexal lymphoproliferative disease (OALD) was
relatively uncommon diagnosis among caruncu-
lar lesions [1]
OALD was seldom described in Asian popula-
tion especially for young age C-Y Cheng re-
ported age-standardized incidence of ocular
adnexal lymphomas (OAL) in Taiwan from 1979
to 1996 was below 07 per million per year and
mean age was 531 years old [2] In 2015 five
Taiwanese cases of OAL whose age ranging
from 45 to 64 were presented [3] However
there were few cases of conjunctival OAL or
RLH in Chinese pediatric patient
Here we present a case of 16-year-old boy with a
caruncular mass at his left eye with recurrence
one month after excision We describe his clini-
cal symptoms photographs pathological results
management and follow-up clinical course in
this report
CASE REPORT A 16-year-old healthy boy presented a mass
lesion at his left eye caruncle accompanied with
the symptom of tearing for one month (Figure 1)
He had no ocular pain no itchiness no blurred
vision no night sweating no fever and no body
weight loss The patient denied systemic diseas-
es and histories of surgery His bilateral best
corrected visual acuity (BCVA) were 66 and
intraocular pressure (IOP) were both within
normal range There were no remarkable find-
ings for his cornea lens fundus and physical
examination Excision was performed and the
mass was soft with fluid inside therefore con-
junctival pyogenic cyst was our initial diagnosis
However one month after the excision a pro-
truding mass recurred at the patientrsquos nasal can-
thus of left eye (Figure 2) There were some
differences compared to previous condition At
the first time the soft mass was contained in a
well-defined cyst wall which more favored py-
ogenic granulation However after short period
of recurrence solid consistency and unclear
margin were found which favored malignancy
Besides the mass partially involved beyond the
gray line of nasal part lower eyelid whereas last
time the cyst mainly extended from conjunctiva
of caruncle The second excisional biopsy was
performed Pathologic examination demonstrat-
ed abundant atypical lymphoid proliferation
(Figure 3A 3B) Immunohistochemical studies
showed that the lymphoid aggregation was
composed predominantly of CD20-positive cells
(Figure 3C) focal positive staining of CD3
(Figure 3D) CD5 CD23 CD10 and negative
staining of cyclin-D1 Unfortunately the cellular
morphology was difficult to be evaluated due to
marked crushing artifact Thus malignant lym-
phoma cannot be excluded totally
Orbital computed tomography (CT) showed a
lesion of soft tissue density at medial canthus of
left orbit without obvious nasolacrimal duct or
bony invasion (Figure 4A) Magnetic resonance
imaging (MRI) with contrast showed strong
enhancement at left medial canthus region (Fig-
ure 4B) There was no remarkable finding in the
systemic workup including complete blood
count and differential count biochemical pro-
files and 18F-fluoro-2-deoxyglucose positron
emission tomographycomputed tomography
(18F-FDG PETCT) indicating no evidence of
systemic involvement
After the second excision we preferred con-
servative management for him due to the uncer-
tainty of malignancy and to avoid side effects
from aggressive treatment No sign of recurrence
was noted after 10 months of observation The
follow-up photo was taken at three months after
the second operation (Figure 5)
DISCUSSION Ocular adnexal lymphoproliferative disease
(OALD) consists of the spectrum of lymphoid
disease affecting the tissues surrounding the eye
including ocular adnexal lymphomas (OAL) and
lymphoid hyperplasia (LH) [4] The conjunctiva
is an important location for extranodal lympho-
ma development which comprises 25 of OAL
[5]
OAL can be grouped into two categories based
on their appearance of cells under the micro-
scope low-grade and high-grade [6] Extranodal
marginal zone lymphoma of mucosa-associated
lymphoid tissue (EMZLMALT) is the most
common subtype of OAL followed by follicular
lymphoma [7-9] Both of the above are
low-grade lymphomas
LH can be further divided by histopathology into
reactive lymphoid hyperplasia (RLH) and atypi-
cal lymphoid hyperplasia (ALH) RLH has to-
tally benign morphology and immunophenotype
whereas ALH has borderline lesions between
RLH and lymphoma [10] OAL and LH are
mostly seen in patients with age between 50-70
years old There are rare cases in pediatric group
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
114
[71011] In the C-Y Chengrsquos statistical report of
OAL in Taiwan only 8 patients were younger
than 15 years old among the 101 cases of ocular
lymphoma [2] According to an US study inci-
dence rates of OAL were analyzed in different
age groups the group of age over 50 had the
highest incidence rate of 574 per million per-
son-years while the 0-19 age group had the
lowest incidence rate of 009 per million per-
son-years [12] The incidence of LH was even
less than OAL [13]
Patients with OALD may be asymptomatic or
with symptoms of proptosis eyelid swelling a
palpable painless mass or conjunctival salmon
patch Diplopia visual loss pain or inflamma-
tion occurred less frequently implying more
aggressive features [714]
Orbital LH is not distinguishable from low-grade
lymphoma radiologically They both typically
present a round or lobulated mass that diffusely
moderately enhances with contrast and usually
shows homogenous hypointense or isointense to
muscle barely invasion to bone or nervous sys-
tem [10] Atypical appearances including inho-
mogeneous calcification or bony changes may
be seen in high-grade lymphoma case reports
such as ocular adnexal diffuse large B-cell lym-
phoma (DLBCL) which is one of the more ag-
gressive type of OAL [7] Whole body PET is
used for not only the evaluation of systemic
involvement but also the standard for staging
lymphoma Our patientrsquos image studies revealed
neither obvious local invasion nor systemic ma-
lignancy indicating high-grade lymphoma was
less likely Low-grade lymphoma and benign
reactive lymphoid hyperplasia were still under
consideration
Histomorphology analysis and immunohisto-
chemistry (IHC) are essential for diagnosis
Flow cytometry and polymerase chain reaction
(PCR) technique are also applied to help differ-
entiate from RLH and OAL [1016] Our case
had immunohistochemical profile of positivity
for CD20 predominantly positivity focally for
CD3 CD5 CD10 CD23 and negativity for cy-
clin-D1 BCL-6 staining was not performed in
our casersquos biopsy Thus according to the IHC
report RLH ALH and follicular lymphoma are
probable diagnosis of our patient
Radiation therapy is the standard treatment for
low-grade OAL that is classified as T1N0M0 or
T2N0M0 according to the AJCC criteria [15]
İncesoy-Ouml zdemir S et al reported a 10-year-old
boy diagnosed of MALT lymphoma who was
treated with local radiotherapy (36 Gy) and
there were no local or systemic recurrences dur-
ing his nearly four-year follow-up [17] Another
case report represented a 21-year-old man of
conjunctival follicular lymphoma treated with
surgical excision only showing no evidence of
recurrence after 8 months follow-up [18] Other
treatment options for pediatric and juvenile OAL
were performed in some case reports including
intravenous rituximab intralesional interfer-
on-α-2b topical interferon a6 systemic doxycy-
cline surgical excision and postoperative local
cryotherapy [15]
Treatment for young conjunctival RLH was less
discussed in the past In a case series article
three children (9 13 14 years old respectively)
of RLH received surgical resection without fur-
ther postoperative management and no signs of
recurrence were noted during follow-up [19]
Short-term topical and oral corticosteroids after
surgical excision were prescribed in two pediat-
ric RLH patients for their small residual mass
However poor response in both cases was nota-
ble [20]
Our patient declined to receive radiotherapy or
any further postoperative treatment mainly due
to his concerning of possible side effects (such
as dry eye and cataract)
CONCLUSION We present a rare case of caruncle mass in this
report OALD is one of the relatively uncommon
diagnosis among caruncular lesions OALD
includes benign RLH and malignant OAL
which are both mainly seen in elderly patients
even rarer in pediatric or juvenile group
The standard treatment for low-grade OAL and
RLH in young patents are still debatable How-
ever long-term follow-up is suggested for both
OAL and RLH patients Though RLH has a be-
nign and self-limited course risk of malignant
transformation is possible
REFERENCES 1 Levy J Ilsar M Deckel Y et al Lesions of
the caruncle a description of 42 cases and
a review of the literature Eye
200923(5)1004-1018
2 C-Y Cheng and W-M Hsu Incidence of
eye cancer in Taiwan an 18-year review
Eye 200418152-158
3 Chui-Lien Tsen Muh-Chiou Lin
Youn-Shen Bee et al Ocular adnexal
lymphoma Five case reports and a
literature review Taiwan Journal of
Ophthalmology 20155(2)99-102
4 Liesegang TJ Ocular adnexal
lymphoproliferative lesions Mayo Clin
Proc 199368(10)1003-1010
5 Kirkegaard MM Coupland SE Prause JU
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
115
et al Malignant lymphoma of the
conjunctiva Surv Ophthalmol
201560(5)444-458
6 Stacy RC Jakobiec FA Schoenfield L et
al Unifocal and multifocal reactive
lymphoid hyperplasia vs follicular
lymphoma of the ocular adnexa Am J
Ophthalmol 2010150(3)412-426
7 Sullivan TJ Ocular Adnexal
Lymphoproliferative Disease In Guthoff
RF Katowitz JA eds Oculoplastics and
Orbit Berlin Heidelberg Springer
20101-19
8 White Valerie A Understanding and
Classification of Ocular Lymphomas
Ocular Oncology and Pathology
20195379-386
9 Stefanovic A Lossos IS Extranodal
marginal zone lymphoma of the ocular
adnexa Blood 2009114(3)501-510
10 Andrew NH Coupland SE Pirbhai A et al
Lymphoid hyperplasia of the orbit and
ocular adnexa A clinical pathologic review
Surv Ophthalmol 201661(6)778-790
11 Ferry JA1 Fung CY Zukerberg L et al
Lymphoma of the ocular adnexa A study
of 353 cases Am J Surg Pathol
200731(2)170-184
12 WM Hassan MS Bakry HM Hassan et al
Incidence of orbital conjunctival and
lacrimal gland malignant tumors in USA
from Surveillance Epidemiology and End
Results 1973-2009 Int J Ophthalmol
20169(12)1808-1813
13 Ajay A Rao John H Naheedy James Y-Y
Chen et al A Clinical Update and
Radiologic Review of Pediatric Orbital
and Ocular Tumors Journal of Oncology
2013(9)975908
14 Sullivan TJ Whitehead K Williamson R
et al Lymphoproliferative disease of the
ocular adnexa a clinical and pathologic
study with statistical analysis of 69
patients Ophthal Plast Reconstr Surg
200521177-188
15 Tanenbaum RE Galor A Dubovy SR et al
Classification diagnosis and management
of conjunctival lymphoma Eye Vis (Lond)
2019622
16 Olga Klavdianou Georgios Kondylis
Vasileios Georgopoulos et al Bilateral
benign reactive lymphoid hyperplasia of
the conjunctiva a case treated with oral
doxycycline and review of the literature
Eye Vis (Lond) 2019626
17 İncesoy-Ouml zdemir S Yuumlksek N Bozkurt C
et al A rare type of cancer in children
extranodal marginal zone B-cell (MALT)
lymphoma of the ocular adnexa Turk J
Pediatr 201456(3)295-298
18 Lynn J Poole Perry Frederick A Jakobiec
Peter A D Rubin Conjunctival Pediatric
Follicular Lymphoma Arch Ophthalmol
2012130(7)941-943
19 Abdullah Al-Mujaini Upender Wali
Anuradha Ganesh1 et al Ocular Adnexal
Reactive Lymphoid Hyperplasia in
Children Middle East Afr J Ophthalmol
201219(4)406-409
20 McLeod SD Edward DP Benign
lymphoid hyperplasia of the conjunctiva in
children Arch Ophthalmol
1999117(6)832-835
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
116
FIGURES
Figure 1 Slit lamp image of a mass lesion at the patientrsquos left eye caruncle for one month
Figure 2 One month after the first excision a protruding mass recurred at the patientrsquos nasal canthus
of left eye It partially involved beyond the gray line of nasal part lower eyelid
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
117
Figure 3 Histomorphology analysis and immunohistochemistry study of the caruncular lesion Abun-
dant atypical lymphoid proliferation presented in low-power photomicrograph (A) and
high-power photomicrograph (B) under hematoxylin-eosin staining The lymphoid aggrega-
tion was composed predominantly of CD20-positive cells (C) and focal positive staining of
CD3 (D)
Figure 4 Non-contrast orbital computed tomography showed a lesion of soft tissue density at medial
canthus of left orbit without obvious nasolacrimal duct or bony invasion (A) Magnetic reso-
nance imaging with contrast showed strong enhancement at left medial canthus region (B)
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
118
Figure 5 The follow-up photo were taken at three months after the second excision showing no signs
of recurrence
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
119
Juvenile Caruncular Atypical Lymphoid Proliferation ndash A Rare Case Report
罕見病例報告mdash青少年之淚阜非典型淋巴增生
施驊瑋 1林友祺 1
中文摘要
淚阜病灶相當罕見大部分為良性病灶眼睛及附屬結構淋巴增生疾病為其
鑑別診斷之一非常少見於年輕人或兒童我們報告一位 16歲的健康男性因
左眼淚阜無痛性腫塊接受切除手術卻於術後一個月復發執行第二次切除手術
後門診追蹤十個月未再復發此案例表現了部分良性與部分惡性腫瘤的特徵
我們針對反應性淋巴增生眼睛及附屬結構淋巴癌兩個疾病做討論及文獻回顧
關鍵字淚阜病灶眼睛及附屬結構淋巴增生疾病眼睛及附屬結構淋巴癌反
應性淋巴增生非典型淋巴增生
1 新光吳火獅紀念醫院眼科
通訊作者林友祺 電子信箱 yuchi067gmailcom
Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh 120
Submitted March 26 2020
Final version accepted April 16
2020
Case Report
Hyperacute intramembranous hemor-
rhage after burr hole craniostomy for
chronic subdural hematoma
Cite as Meng-Chi Lin Jui-Ming
Sun Yu-Hao Chen Cheng-Ta
Hsieh
Hyperacute intramembranous
hemorrhage after burr hole crani-
ostomy for chronic subdural he-
matoma Fu-Jen Journal of Medi-
cine 3(4) 120-125 2020
DOI
103966181020932020091803004
Meng-Chi Lin1 Jui-Ming Sun23 Yu-Hao Chen24 Cheng-Ta
Hsieh567
1Department of Surgery Zuoying Branch Kaohsiung Armed Forces
General Hospital Kaohsiung 813 Taiwan 2Section of Neurosurgery Department of Surgery Chia-Yi Christian
Hospital Chia-Yi City 600 Taiwan 3Department of Biotechnology Asia University Taichung City 41354
Taiwan 4Chung-Jen Junior College of Nursing Health Sciences and Manage-
ment Chia-Yi Country 62241 Taiwan 5Division of Neurosurgery Department of Surgery Sijhih Cathay Gen-
eral Hospital New Taipei City 22174 Taiwan 6Department of Medicine School of Medicine Fu Jen Catholic Univer-
sity New Taipei City 24205 Taiwan 7Department of Neurological Surgery Tri-Service General Hospital
National Defense Medical Center Taipei 114 Taiwan
Corresponding author E-mail address
nogormail2000comtw (Cheng-Ta Hsieh)
ABSTRACT
Burr hole craniostomy with closed-system drainage is an effective and common neurosurgical procedure to manage chronic subdural hematoma Postoperative hem-orrhage a well-known but infrequent complication may result in increased neurolog-ical deficits However hyperacute intramembranous hemorrhage within the inner and outer membrane of hematoma after burr hole craniostomy with irrigation and closed-system drainage has not been described previously Herein we report a case of postoperative spontaneous hyperacute intramembranous hemorrhage after burr hole craniostomy with closed-system drainage to manage a chronic subdural hematoma we subsequently discuss the possible pathophysiological mechanisms and review the relevant literature
Keywords Chronic subdural hematoma acute subdural hematoma bleeding burr hole craniostomy
drainage
Fu-J
Meng
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Jen Journal o
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Vol 3 No 4 2
Acute intram
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EFERENCRohde VComplicatiand closedsubdural analysis of
active bleedinerved Histolonized hematots and capilla
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ON oman had a hi
gular medicatig nutritional ma lucidum referred to ohe became proxamination rScale ratings wgth score in th
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CES V Graf Gons of burr-
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Vol 3 No 4 2
Acute intram
Yu-Hao Chen
vealing a layer
displaying a m
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2020
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Cheng-Ta Hs
red type of CS
midline shift
ns (A) Bone w
(white arrow)
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123
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Vol 3 No 4 2
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124
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Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh
125
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
慢性硬腦膜下出血進行鑽顱引流手術造成超急性夾膜內出
血
林孟楫 1孫瑞明 23陳昱豪 24謝政達 567
中文摘要
鑽顱併封閉系統引流手術是治療慢性硬腦膜下出血患者一種有效且常見的
神經外科手術方式術後出血可能導致神經功能缺損惡化是眾所周知但不常見
的併發症之一然而至今仍未有鑽孔併封閉系統引流造成原本慢性硬腦膜血
塊內膜和外膜間急性夾膜間出血案例在這裡我們報告一例慢性硬腦膜下出
血病患者接受鑽顱併封閉系統引流手術治療造成術後急性夾膜間出血我們在
本文中討論可能的致病機制並回顧相關文獻
關鍵字慢性硬腦膜下出血急性硬腦膜下出血出血鑽顱術引流
1國軍高雄總醫院左營分院 外科部
2崇仁醫護管理專科學校
3亞洲大學 生物科技學系
4戴德森醫療財團法人嘉義基督教醫院 外科部 神經外科
5汐止國泰綜合醫院 神經外科
6輔仁大學 醫學系
7 國防醫學院 三軍總醫院 神經外科
通訊作者謝政達 電子信箱 nogormail2000comtw
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
126
Submitted January 21 2020
Final version accepted July 08
2020
Case Report
Hamartoma of the breast A case report
Cite as Hsuan-An Chen
Cheng-Yu Lo Shih-Hung Huang
Chin-Lung Lin
Hamartoma of the breast A case
report Fu-Jen Journal of Medicine
3(5) 126-130 2020
DOI
103966181020932020091803005
Hsuan-An Chen1 Cheng-Yu Lo
3 Shih-Hung Huang
3 Chin-Lung
Lin2
1Department of Surgery Cathay General Hospital Taipei Taiwan
2Department of General Surgery Cathay General Hospital Taipei Tai-
wan
3Department of Pathology Cathay General Hospital Taipei Taiwan
Corresponding author E-mail address
lungyungmailcom (Chin-Lung Lin)
ABSTRACT
Breast hamartoma is an uncommon benign tumor rarely associated with malignancy An
excision and histological examination is necessary for the differential diagnosis We report
a case of a 49-year-old female patient presenting with a lump in the right breast Ultrasound
examination which demonstrated a 4411 cm hypoechoic lesion with lipoma Partial mas-
tectomy was arranged and the diagnosis of a hamartoma was confirmed by the histological
examination
Keywords Breast tumor Hamartoma Ultrasound
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
127
INTRODUCTION The hamartoma is a benign tumor-like lesion
that can affect various organs of the body in-
cluding lungs kidneys skin and more rarely the
breast In 1981 the hamartomas were recognized
in the WHO classification[1] They are defined
as well-demarcated mass of mammary ducts and
lobules containing varying amounts of fibrous
and adipose tissue and producing a distinctive
mammographic image
CASE REPORT A 49 year-old female had past history of left
breast mastitis with abscess status post partial
mastectomy This time she presented to our out
patient clinic for breast examination Physical
examination revealed a painless palpable mova-
ble and painless lump at upper outer quadrant of
right breast The risk of breast cancer was not
noted and the patient did not have any family
history of breast cancer The patient also denied
any trauma history before Ultrasound examina-
tion was arranged which demonstrated a 4411
cm hypoechoic lesion with lipoma at 3 oclock 2
cm from nipple of right breast and multiple hy-
poechoic nodules of various size in both breasts
and there was no suspicious axillary lymph
nodes noted (Figure1) Surgical treatment was
arranged partial mastectomy of right breast
harmartoma was successfully performed A 32 x
31 x 21 cm tumor was completely excised
Grossly examination showed a gray to yellow
and firm to fatty The diagnosis of a hamartoma
was confirmed by the histological examination
Microscopically sections of the breast lesion
show mammary hamartoma composed of ducts
lobules with interlobular fibrous tissue and adi-
pose tissue Fibrocystic change apocrine meta-
plastic ducts and scattered foci of adenosis are
noted The overall lobulocentric architecture and
the 2-cell pattern of the epithelium are preserved
columnar cell change and focal microcalcifica-
tion are present (Figure2) Based on submitted
biopsy specimen in-situ or invasive tumor cells
are not identified
DISCUSSION Hamartoma of the breast is a benign tumor like
nodule it was also known as fibroadenolipoma
lipofibroadenoma or adenolipoma based on its
predominant components It was composed of
varying amounts of glandular adipose and fi-
brous tissue[2] Hamartomas were first described
in 1971 by Arrigoni et al in a study of 10 patients
which breast tumors clinically and grossly re-
sembled fibroadenomas[3]
A higher predominance of tumors exists in fe-
males compared with males Hamartomas are
slowly-growing lesions with the diameter rang-
ing from 2 cm to 5 cm sometimes hamartomas
can reach giant diameter [4]
The clinical diagnosis of hamartoma is based on
the findings from mammography sonography
and histology examinations The hamartomas are
usually incidentally diagnosed by the women
older than 40 year-old starting mammography
screening
On physicial examination harmatomas are usu-
ally occult painless they may be as large mo-
bile soft to firm masses[5] Ultrasound showed
well capsulated mass with echogenic rim and
internal heterogeneity Mammography exam
showed well-circumscribed round to oval
masses containing fat and soft tissue densities
with a thin radiopaque pseudocapsule The
pseudocapsule results from displacement of
breast parenchyma by the tumor [56] In Pa-
thology finding microglandular adenosis is pre-
sent in fibroadipose stroma surrounded by a thin
fibrous capsule It composed of a combination of
epithelial and stromal elements usually with
normal ducts or lobules although variations of
normal tissue may also be seen Fibroadenoli-
poma myoid hamartoma and chondrolipoma are
histological variations of hamartomas depend-
ing on the proportion of normal breast tissue
elements[7]
Malignancy associated with hamartomas are
very rare[8] However it has been reported
hamartomas develop into carcinoma Malignant
transformation can occur as a result of cellular
atypia in the epithelial component of the mass[9]
Surgical removal is the curative method for
breast hamartomas[10] Diagnostic material such
as mammography ultrasonography or core nee-
dle biopsy may not give the definitive diagnosis
Therefore surgical excision and histological
examination is necessary for differential diagno-
sis[111213]
Although it is rare hamartoma can be seen along
with malignancy as it is formed from similar
components of breast tissue Therefore careful
diagnosis and appropriate management including
surgery are required
REFERENCES 1 World Health Organization (1981)
Histological typing of breast tumors In
International histological classification of
tumors 1981 2nd ed
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
128
2 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11435ndash449
2006
3 ArrigoniMG DockertyMB JuddES
The identificationand treatment of
mammary hamartoma Surg Gynecol
Obstet1971 133 577-82
4 Sanal HT Ersoz N Altinel O Unal E Can
C Giant hamartoma of the breast Breast J
2006 12 84-85
5 Feder JM de Paredes ES Hogge JP
Wilken JJ Unusual breast lesions
radiologic-pathologic correlation
Radiographics 1999 19S11ndashS26
6 Murat A Ozdemir H Yildirim H Poyraz
AK Ozercan R Hamartoma of the breast
Australas Radiol 200751 Spec NoB37ndash
9
7 Fisher CJ Hanby AM Robinson L Millis
RR Mammary hamartoma-a review of 35
cases Histopathology 1992 20 99-106
8 Choi N Ko ES Invasive ductal carcinoma
in a mammary hamartoma case report and
review of the literature Korean J Radiol
2010 Nov-Dec11(6)687-91
9 Lee EH Wylie EJ Bourke AG Bastiaan
De Boer W Invasive ductal carcinoma
arising in a breast hamartoma two case
reports and a review of the literature Clin
Radiol 2003 58 80-3
10 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11 435 ‑449
2006
11 Coyne J Hobbs FM Boggis C Harland R
Lobular carcinoma in a mammary
hamartoma J Clin Pathol 199245936ndash
937
12 G M K Tse B K B Law T K F Ma A B W
Chan Hamartoma of the breast a
clinicopathological review J Clin Pathol
200255951ndash954
13 RAAmir SSheikh BreasthamartomaA
report of 14cases of an under-recognized
and under-reported entity International
Journal of Surgery Case Reports
22(2016)1ndash4
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
129
FIGURES
Figure 1 Ultrasound shows a 4411 cm hypoechoic lesion with lipoma at 3 oclock 2 cm from nipple
of right breast
Figure 2 Photomicrograph shows mammary hamartoma composed of ducts lobules with interlobular
fibrous tissue and adipose tissue
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
130
Hamartoma of the breast A case report
乳房錯構瘤罕見個案報告
陳宣安 1羅承裕 3黃世鴻 3林錦龍 2
中文摘要
乳房錯構瘤是一種罕見之乳房良性腫瘤切除手術及病理化驗來做鑑別診斷
我們報告一位 49歲女性以可觸摸到無痛性右側乳房腫塊為臨床表徵超音波
看到一個邊緣清楚低迴音的腫塊病患接受手術切除病灶病理診斷證實為乳
房錯構瘤
關鍵字乳房腫瘤錯構瘤超音波攝影
1國泰綜合醫院外科部
2國泰綜合醫院一般外科
3國泰綜合醫院病理科
通訊作者林錦龍 電子信箱 lungyungmailcom
Fu-Jen Journal of Medicine
Mission and Goals
The Fu-Jen Journal of Medicine (FJJM) is a peer-reviewed journal which
aims to enhance research quality of staffs in the College of Medicine Fu Jen
Catholic University The journal publishes original investigations across a
wide range of medical disciplines including original research articles in basic
and clinical sciences case reports review articles brief reports and letter
to the editor FJJM is now issued by the Center of Medical Education in the
College of Medicine Fu Jen Catholic University To promote journal quality
the manuscript submitted to FJJM after August first 2015 has to be prepared
in English to meet the international standards
Issue Date
Publication Date
Institution
December 01 2003
September 30 2020
College of Medicine Fu Jen Catholic University
Honorable publisher Han-Sun Chiang
Publisher Ping-Keung Yip
Editor-in-chief Ming-Chieh Ma
Associate Editors Yu-Wen Lin
Editors
Telephone (02) 2905-3477
Address Center for Medical Education College of Medicine Fu Jen
Catholic University
No 510 Zhongzheng Rd Xinzhuang Dist New Taipei City
24205 Taiwan
Su-Jane Wang Chi-Chung Wang Chih-Ming Ho
Yih-Jing Lee Chih-Shung Wong Tze-Wah Kao
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Chia-Chen Lu Zai-Ting Yeh
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- 9月封面
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Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 103
5 Hutchinson A Young TA Cooper KL et
al Trends in healthcare incident reporting
and relationship to safety and quality data
in acute hospitals results from the
National Reporting and Learning System
Qual Saf Health Care 2009185-10
6 Mitchell RJ Williamson AM Molesworth
B et al A review of the use of human
factors classification frameworks that
identify causal factors for adverse events
in the hospital setting Ergonomics
2014571443-1472
7 Gurses AP Ozok AA Pronovost PJ Time
to accelerate integration of human factors
and ergonomics in patient safety BMJ
Qual Saf 201221347-351
8 Health and Safety Executive Introduction
to human factors
httpwwwhsegovukhumanfactorsintro
ductionhtm
9 Wiegmann DA Shappell SA A human
error approach to aviation accident
analysis The human factors analysis and
classification system Burlington VT
Ashgate Publishing Ltd 2003
10 Yu-Hsun Cheng Sheng-Hui Hung
Tung-Wen Ko et al An Analysis of the
Reliability and Validity of Human Factors
Analysis Classification System in Medical
Adverse Events Journal of Healthcare
Quality 20191370-76
11 Taiwan Joint Commission on Hospital
Accreditation Taiwan Patient-Safety
Reporting System Annual Report 2017
New Taipei City Taiwan
12 Taiwan Patient Safety Net
httpwwwpatientsafetymohwgovtwCo
ntentzMessagesslistaspxSiteID=1ampMm
mID=621273300317401756
13 Government of Western Australia
Department of Health
httpsww2healthwagovauArticlesS_T
Severity-assessment-codes
14 Farley DO Haviland A Champagne S et
al Adverse-event-reporting practices by
US hospitals results of a national survey
Qual Saf Health Care 200817416-423
15 Shojania KG Thomas EJ Trends in
adverse events over time why are we not
improving BMJ Qual Saf
201322273-277
16 Levitt P Challenging the systems approach
why adverse event rates are not improving
BMJ Qual Saf 2014231051-1052
17 Kellogg KM Hettinger Z Shah M et al
Our current approach to root cause
analysis is it contributing to our failure to
improve patient safety BMJ Qual Saf
201726381-387
18 Khorsandi M Skouras C Beatson K et al
Quality review of an adverse incident
reporting system and root cause analysis of
serious adverse surgical incidents in a
teaching hospital of Scotland Patient Saf
Surg 2012621
19 Diller T Helmrich G Dunning S et al
The Human Factors Analysis
Classification System (HFACS) Applied to
Health Care Am J Med Qual
201429181-190
20 Carayon P Xie A Kianfar S Human
factors and ergonomics as a patient safety
practice BMJ Qual Saf 201423196-205
21 Reason J Human Error New York
Cambridge University Press 1990
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 104
TABLE
Table 1 Incidences by Category (N=40)
CategorySAC SAC 4 SAC 3 SAC 2 SAC 1 total
Laboratory and ex-
amination events
4 10 2 0 16 (400)
Clinical care event 6 2 1 0 9 (225)
Medication event 5 0 2 0 7 (175)
Surgery-related event 1 1 2 0 4 (100)
Transfusion-related
event
1 1 0 0 2 (50)
Tube event 0 1 0 0 1 (25)
Public accident 0 0 1 0 1 (26)
Total 17 (425) 15 (375) 8 (200) 0 40 (100)
SAC 1113 Severity Assessment Code SAC
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 105
FIGURES
Figure 1 Active Failures (N=40)
16 (167)
66 (1000)
640 (150)
235 (57)
735 (200)
2435 (686)
2435 (686)
3540 (875)
438 (105)
438 (105)
738 (184)
1938 (500)
3138 (816)
3840 (950)
0 5 10 15 20 25 30 35 40
Commits WidespreadRoutine Violation
Performs Work-Around Violation
Ignored a CautionWarning
Failure to Prioritize Tasks Adequately
Wrong Choice of Action During an Operation
Inadequate Real‐Time Risk Assessment
Rushed or Delayed a Necessary Action
Breakdown in Visual Scan
Over-ControlledUnder-Controlled AircraftVehicleSystem
Unintended Operation of Equipment
Procedure Not Followed Correctly
Performance-Based Errors
Judgment and Decision Making Errors
Violations
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 106
Figure 2 Preconditions (Latent Failures or Conditions) (N=40)
14 (250)
24 (500)
48 (500)
11 (1000)
18 (125)
840 (200)
0 5 10 15 20 25 30 35 40
Seat and Restraint System Problems
Instrumentation amp Warning System Issues
Noise Interference
Environment
Physical Environment
Technological Environment
27 (286)
27 (286)
27 (286)
37 (129)
47 (511)
47 (571)
77 (1000)
24 (500)
44 (1000)
47 (571)
12 (500)
22 (1000)
27 (286)
740 (175)
0 5 10 15 20 25 30 35 40
Technical or Procedural Knowledge Not Retained After Training
InterferenceInterruption
Task OverUnder Saturation
Distraction
Negative Habit Transfer
Not Paying Attention
Complacency
Overconfidence
Physical IllnessInjury
Fatigue
Physical and Mental State
Physical Problem
State of Mind
Mental Awareness
211 (182)
311 (273)
311 (273)
411 (364)
811 (7227)
911 (818)
1140 (275)
0 5 10 15 20 25 30 35 40
Inadequate Task Delegation
TaskMission PlanningBriefingDebriefing Inadequate
Failure of CrewTeam Leadership
StandardProper Terminology Not Used
Critical Information Not Communicated
Failed to Effectively Communicate
Teamwork
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 107
Figure 3 Supervision (Direct Supervisory Chain of Command) (N=40)
Figure 4 Organization Influence (Upper-Level Management Command Level) (N=40)
114 (71)
114 (71)
214 (143)
314 (214)
1314 (929)
1440 (350)
511 (455)
511 (455)
711 (636)
1140 (275)
47 (571)
67 (857)
740 (175)
0 5 10 15 20 25 30 35 40
Selected Individual with Lack of Proficiency
Improper Role‐modeling
Failed to Provide Proper Training
Failed to IdentifyCorrect Risky or Unsafe Practices
SupervisoryCommand Oversight Inadequate
Performed Inadequate Risk Assessment ‐Formal
Selected Individual with Lack of Current or Limited Experience
Authorized Unnecessary Hazard
Allowing Unwritten Policies to Become Standard
Failure to Enforce Existing Rules
Supervisory Violations
Planned Inappropriate Operations
Inadequate Supervision
12 (500)
12 (500)
240 (50)
110 (100)
510 (500)
1040 (250)
11 (1000)
140 (25)
18 (125)
18 (125)
38 (35)
48 (500)
840 (200)
0 5 10 15 20 25 30 35 40
Organizational Over-confidence or Under-confidence in Equipment
Organizational Culture (attitude actions) Allows for Unsafe TaskMission
Purchasing or Providing Poorly Designed or Unsuitable Equipment
Organizational ProgramPolicy Risks not Adequately Assessed
Failure to Provide Adequate Manning Staffing Resources
Failure to remove inadequate worn-out equipment in timely manner
Inadequate infrastructure
Command and control resources are deficient
Failure to provide adequate operational information resources
Resource Problems
Personnel Selection amp Staffing
Policy and Process Issues
ClimateCulture Influences
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 108
Supplement Table 1- HFACS Content of Human Factor Analysis Classifi-
cation System [9] Tier main level sub-item nano code
Tier 1 Unsafe Acts
Perfor-
mance-Based
Errors
Unintended operation of equipment
Checklist not followed correctly
Procedure not followed correctly
Over-controlledunder-controlled aircraftvehiclesystem
Breakdown in visual scan
Rushed or delayed a necessary action
Judgment amp De-
cision-Making
Errors
Inadequate real‐time risk assessment
Failure to prioritize tasks adequately
Ignored a cautionwarning
Wrong choice of action during an operation
Violations
Performs work-around violation
Commits widespreadroutine violation
Extreme violation-lack of discipline
Tier 2 Preconditions
Environment
Physical environment
Environmental conditions affecting vision
Vibration effects vision or balance
Heatcold stress impairs performance
External force of object impeded an individualrsquos
movement
Lights of other vehiclevesselaircraft affected vision
Noise interference
Technological environment
Seat and restraint system problems
Instrumentation amp warning system issues
Visibility restrictions (not weather related)
Controls and switches are inadequate
Automated system creates unsafe situation
Workspace incompatible with operation
Personal equipment interference
Communication equipment inadequate
Physical and
Mental State
Physical problem
Substance effects (alcohol supplements medications
drugs)
Loss of consciousness (sudden or prolonged onset)
Physical illnessinjury
Fatigue
Inadequate adaptation to darkness
Dehydration
Body sizemovement limitations
Physical strength amp coordination (inappropriate for
task demands)
Nutritiondiet
State of mind
Psychological problem
Life stressors
Emotional state
Personality style
Overconfidence
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 109
Pressing
Complacency
Motivation
Motivational exhaustion (burnout)
Sensory misperception
Motion illusion-kinesthetic
Turning illusionbalance-vestibular
Visual illusion
Misperception of changing environment
Misinterpreted misread instrument
Misinterpretation of auditorysound cues
Spatial disorientation
Temporaltime distortion
Mental awareness
Not paying attention
Fixation
Task overunder saturation
Confusion
Negative habit transfer
Distraction
Geographically lost
Interferenceinterruption
Technical or procedural knowledge not retained after
training
Inaccurate expectation
Teamwork
Failure of crewteam leadership
Inadequate task delegation
Rankposition intimidation
Lack of assertiveness
Critical information not communicated
Standardproper terminology not used
Failed to effectively communicate
Taskmission planningbriefingdebriefing inadequate
Tier 3 Supervision
Supervisory Vio-
lations
Failure to enforce existing rules
Allowing unwritten policies to become standard
Directed individual to violate existing regulations
Authorized unqualified individuals for task
Planned Inappro-
priate Operations
Directed task beyond personnel capabilities
Inappropriate team composition
Selected individual with lack of current or limited experience
Performed inadequate risk assessment ‐formal
Authorized unnecessary hazard
Inadequate Su-
pervision
Supervisorycommand oversight inadequate
Improper role‐modeling
Failed to provide proper training
Failed to provide appropriate policyguidance
Personality conflict with supervisor
Lack of supervisory responses to critical information
Failed to identifycorrect risky or unsafe practices
Selected individual with lack of proficiency
Tier 4 Organizational
Influences
Resource Prob-
lems
Command and control resources are deficient
Inadequate infrastructure
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 110
Failure to remove inadequate worn-out equipment in timely
manner
Failure to provide adequate operational information resources
Fail to provide adequate funding
Personnel Selec-
tion amp Staffing
Personnel recruiting amp selection policies are inadequate
Failure to provide adequate manning staffing resources
Policy amp Process
Issues
Pace of ops-tempoworkload
Organizational programpolicy risks not adequately assessed
Provided inadequate procedural guidance or publications
Organizational (formal) training is inadequate or unavailable
Flawed doctrinephilosophy
Inadequate program management
Purchasing or providing poorly designed or unsuitable equip-
ment
ClimateCulture
Influences
Organizational culture (attitude actions) allows for unsafe
taskmission
Organizational over-confidence or under-confidence in equip-
ment
Unit missionaircraftvehicleequipment change or unit deacti-
vation
Organizational structure is unclear or inadequate
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 111
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
以 HFACS重新檢視根本原因分析案例挖掘造成醫療不良
事件之人為因素
鄭伃洵 1洪聖惠 12柯彤文 3王拔群 14
中文摘要
背景醫療不良事件(AMEs)的管理是促進病人安全的基石根本原因分析
(RCA)是探討重大病人安全不良事件問題但是由於無法解釋更廣泛的因素而受
到限制本研究使用人為因素分類與分析工具(HFACS)回溯審視醫療不良事件
以了解影響醫療不良事件的人為因素及各層面中錯誤原因之分佈或系統性問題
方法本研究回溯 2012-2016年間有做過根本原因分析之醫療不良事件以連續
性取樣方式(continuous sampling)收集 40例醫療不良事件以人為因素分類與分
析工具(HFACS)去系統性的挖掘每件案例發生錯誤之原因結果在行為層面中
分析結果主要為基礎技能錯誤(95)判斷和決策錯誤(875)其中在基礎技能
錯誤當中以未依程序作業執行(816)及未如預期設備操作(50)佔多數判斷和
決策錯誤中以現場風險評估不確實(686)及採取錯的步驟行為(686)佔多數
而在先決條件層面中以團隊合作(275)為主要因素包含溝通不良(818)及重
要訊息未以正確的方式即時傳達(727)佔多數在監督層面當中以監督不周
(929)或監督不妥當(929)為主要因素在組織政策和流程方面(50)以組織
系統的政策風險未充分評估(35)為主要因素結論本研究進一步了解醫療不
良事件在過去使用根本原因分析未探討到的人為因素反映出潛在的監督組織
行為或系統性的問題促進病人安全預防錯誤再發生
關鍵字病人安全醫療不良事件根本原因分析人為因素
1國泰醫療財團法人國泰綜合醫院 品質管理部
2國立臺灣大學健康政策與管理研究所
3振興醫療財團法人振興醫院 醫療品質管理中心
4輔仁大學醫學院
通訊作者王拔群 電子信箱 drtonyseednettw
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin 112
Submitted January 20 2020
Final version accepted April13
2020
Case Report
Juvenile Caruncular Atypical Lymphoid
Proliferation ndash A Rare Case Report
Cite as Hua-Wei Shih Yu-Chi Lin
Juvenile Caruncular Atypical
Lymphoid Proliferation ndash A Rare
Case Report Fu-Jen Journal of
Medicine 3(3) 112-119 2020
DOI
103966181020932020091803003
Hua-Wei Shih1 Yu-Chi Lin
1
1Department of Ophthalmology Shin Kong Wu Ho-Su Memorial Hos-
pital Taipei City Taiwan
Corresponding author E-mail address
yuchi067gmailcom (Yu-Chi Lin)
ABSTRACT
Lesions of the caruncle are very rare Most caruncular lesions are benign though there were still few reported malignant lesions Ocular adnexal lymphoproliferative disease (OALD) one of the differential diagnosis of caruncular lesion is seldom seen in young pa-tient In this article we report a 16-year-old boy with recurrent caruncular atypical lym-phoid proliferation We discuss the epidemiology clinical features images histomorpholo-gy and treatment between ocular adnexal lymphomas (OAL) and reactive lymphoid hyper-plasia (RLH)
Keywords caruncular lesion ocular adnexal lymphoproliferative disease ocular adnexal lymphoma
reactive lymphoid hyperplasia atypical lymphoid proliferation
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
113
INTRODUCTION Lesions of the caruncle are very rare Differen-
tial diagnosis includes nevus myeloproliferative
disorders tumors inflammation infection cysts
vascular lesions and fibrous Biopsy is essential
for diagnosis Levy J et al reported ocular ad-
nexal lymphoproliferative disease (OALD) was
relatively uncommon diagnosis among caruncu-
lar lesions [1]
OALD was seldom described in Asian popula-
tion especially for young age C-Y Cheng re-
ported age-standardized incidence of ocular
adnexal lymphomas (OAL) in Taiwan from 1979
to 1996 was below 07 per million per year and
mean age was 531 years old [2] In 2015 five
Taiwanese cases of OAL whose age ranging
from 45 to 64 were presented [3] However
there were few cases of conjunctival OAL or
RLH in Chinese pediatric patient
Here we present a case of 16-year-old boy with a
caruncular mass at his left eye with recurrence
one month after excision We describe his clini-
cal symptoms photographs pathological results
management and follow-up clinical course in
this report
CASE REPORT A 16-year-old healthy boy presented a mass
lesion at his left eye caruncle accompanied with
the symptom of tearing for one month (Figure 1)
He had no ocular pain no itchiness no blurred
vision no night sweating no fever and no body
weight loss The patient denied systemic diseas-
es and histories of surgery His bilateral best
corrected visual acuity (BCVA) were 66 and
intraocular pressure (IOP) were both within
normal range There were no remarkable find-
ings for his cornea lens fundus and physical
examination Excision was performed and the
mass was soft with fluid inside therefore con-
junctival pyogenic cyst was our initial diagnosis
However one month after the excision a pro-
truding mass recurred at the patientrsquos nasal can-
thus of left eye (Figure 2) There were some
differences compared to previous condition At
the first time the soft mass was contained in a
well-defined cyst wall which more favored py-
ogenic granulation However after short period
of recurrence solid consistency and unclear
margin were found which favored malignancy
Besides the mass partially involved beyond the
gray line of nasal part lower eyelid whereas last
time the cyst mainly extended from conjunctiva
of caruncle The second excisional biopsy was
performed Pathologic examination demonstrat-
ed abundant atypical lymphoid proliferation
(Figure 3A 3B) Immunohistochemical studies
showed that the lymphoid aggregation was
composed predominantly of CD20-positive cells
(Figure 3C) focal positive staining of CD3
(Figure 3D) CD5 CD23 CD10 and negative
staining of cyclin-D1 Unfortunately the cellular
morphology was difficult to be evaluated due to
marked crushing artifact Thus malignant lym-
phoma cannot be excluded totally
Orbital computed tomography (CT) showed a
lesion of soft tissue density at medial canthus of
left orbit without obvious nasolacrimal duct or
bony invasion (Figure 4A) Magnetic resonance
imaging (MRI) with contrast showed strong
enhancement at left medial canthus region (Fig-
ure 4B) There was no remarkable finding in the
systemic workup including complete blood
count and differential count biochemical pro-
files and 18F-fluoro-2-deoxyglucose positron
emission tomographycomputed tomography
(18F-FDG PETCT) indicating no evidence of
systemic involvement
After the second excision we preferred con-
servative management for him due to the uncer-
tainty of malignancy and to avoid side effects
from aggressive treatment No sign of recurrence
was noted after 10 months of observation The
follow-up photo was taken at three months after
the second operation (Figure 5)
DISCUSSION Ocular adnexal lymphoproliferative disease
(OALD) consists of the spectrum of lymphoid
disease affecting the tissues surrounding the eye
including ocular adnexal lymphomas (OAL) and
lymphoid hyperplasia (LH) [4] The conjunctiva
is an important location for extranodal lympho-
ma development which comprises 25 of OAL
[5]
OAL can be grouped into two categories based
on their appearance of cells under the micro-
scope low-grade and high-grade [6] Extranodal
marginal zone lymphoma of mucosa-associated
lymphoid tissue (EMZLMALT) is the most
common subtype of OAL followed by follicular
lymphoma [7-9] Both of the above are
low-grade lymphomas
LH can be further divided by histopathology into
reactive lymphoid hyperplasia (RLH) and atypi-
cal lymphoid hyperplasia (ALH) RLH has to-
tally benign morphology and immunophenotype
whereas ALH has borderline lesions between
RLH and lymphoma [10] OAL and LH are
mostly seen in patients with age between 50-70
years old There are rare cases in pediatric group
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
114
[71011] In the C-Y Chengrsquos statistical report of
OAL in Taiwan only 8 patients were younger
than 15 years old among the 101 cases of ocular
lymphoma [2] According to an US study inci-
dence rates of OAL were analyzed in different
age groups the group of age over 50 had the
highest incidence rate of 574 per million per-
son-years while the 0-19 age group had the
lowest incidence rate of 009 per million per-
son-years [12] The incidence of LH was even
less than OAL [13]
Patients with OALD may be asymptomatic or
with symptoms of proptosis eyelid swelling a
palpable painless mass or conjunctival salmon
patch Diplopia visual loss pain or inflamma-
tion occurred less frequently implying more
aggressive features [714]
Orbital LH is not distinguishable from low-grade
lymphoma radiologically They both typically
present a round or lobulated mass that diffusely
moderately enhances with contrast and usually
shows homogenous hypointense or isointense to
muscle barely invasion to bone or nervous sys-
tem [10] Atypical appearances including inho-
mogeneous calcification or bony changes may
be seen in high-grade lymphoma case reports
such as ocular adnexal diffuse large B-cell lym-
phoma (DLBCL) which is one of the more ag-
gressive type of OAL [7] Whole body PET is
used for not only the evaluation of systemic
involvement but also the standard for staging
lymphoma Our patientrsquos image studies revealed
neither obvious local invasion nor systemic ma-
lignancy indicating high-grade lymphoma was
less likely Low-grade lymphoma and benign
reactive lymphoid hyperplasia were still under
consideration
Histomorphology analysis and immunohisto-
chemistry (IHC) are essential for diagnosis
Flow cytometry and polymerase chain reaction
(PCR) technique are also applied to help differ-
entiate from RLH and OAL [1016] Our case
had immunohistochemical profile of positivity
for CD20 predominantly positivity focally for
CD3 CD5 CD10 CD23 and negativity for cy-
clin-D1 BCL-6 staining was not performed in
our casersquos biopsy Thus according to the IHC
report RLH ALH and follicular lymphoma are
probable diagnosis of our patient
Radiation therapy is the standard treatment for
low-grade OAL that is classified as T1N0M0 or
T2N0M0 according to the AJCC criteria [15]
İncesoy-Ouml zdemir S et al reported a 10-year-old
boy diagnosed of MALT lymphoma who was
treated with local radiotherapy (36 Gy) and
there were no local or systemic recurrences dur-
ing his nearly four-year follow-up [17] Another
case report represented a 21-year-old man of
conjunctival follicular lymphoma treated with
surgical excision only showing no evidence of
recurrence after 8 months follow-up [18] Other
treatment options for pediatric and juvenile OAL
were performed in some case reports including
intravenous rituximab intralesional interfer-
on-α-2b topical interferon a6 systemic doxycy-
cline surgical excision and postoperative local
cryotherapy [15]
Treatment for young conjunctival RLH was less
discussed in the past In a case series article
three children (9 13 14 years old respectively)
of RLH received surgical resection without fur-
ther postoperative management and no signs of
recurrence were noted during follow-up [19]
Short-term topical and oral corticosteroids after
surgical excision were prescribed in two pediat-
ric RLH patients for their small residual mass
However poor response in both cases was nota-
ble [20]
Our patient declined to receive radiotherapy or
any further postoperative treatment mainly due
to his concerning of possible side effects (such
as dry eye and cataract)
CONCLUSION We present a rare case of caruncle mass in this
report OALD is one of the relatively uncommon
diagnosis among caruncular lesions OALD
includes benign RLH and malignant OAL
which are both mainly seen in elderly patients
even rarer in pediatric or juvenile group
The standard treatment for low-grade OAL and
RLH in young patents are still debatable How-
ever long-term follow-up is suggested for both
OAL and RLH patients Though RLH has a be-
nign and self-limited course risk of malignant
transformation is possible
REFERENCES 1 Levy J Ilsar M Deckel Y et al Lesions of
the caruncle a description of 42 cases and
a review of the literature Eye
200923(5)1004-1018
2 C-Y Cheng and W-M Hsu Incidence of
eye cancer in Taiwan an 18-year review
Eye 200418152-158
3 Chui-Lien Tsen Muh-Chiou Lin
Youn-Shen Bee et al Ocular adnexal
lymphoma Five case reports and a
literature review Taiwan Journal of
Ophthalmology 20155(2)99-102
4 Liesegang TJ Ocular adnexal
lymphoproliferative lesions Mayo Clin
Proc 199368(10)1003-1010
5 Kirkegaard MM Coupland SE Prause JU
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
115
et al Malignant lymphoma of the
conjunctiva Surv Ophthalmol
201560(5)444-458
6 Stacy RC Jakobiec FA Schoenfield L et
al Unifocal and multifocal reactive
lymphoid hyperplasia vs follicular
lymphoma of the ocular adnexa Am J
Ophthalmol 2010150(3)412-426
7 Sullivan TJ Ocular Adnexal
Lymphoproliferative Disease In Guthoff
RF Katowitz JA eds Oculoplastics and
Orbit Berlin Heidelberg Springer
20101-19
8 White Valerie A Understanding and
Classification of Ocular Lymphomas
Ocular Oncology and Pathology
20195379-386
9 Stefanovic A Lossos IS Extranodal
marginal zone lymphoma of the ocular
adnexa Blood 2009114(3)501-510
10 Andrew NH Coupland SE Pirbhai A et al
Lymphoid hyperplasia of the orbit and
ocular adnexa A clinical pathologic review
Surv Ophthalmol 201661(6)778-790
11 Ferry JA1 Fung CY Zukerberg L et al
Lymphoma of the ocular adnexa A study
of 353 cases Am J Surg Pathol
200731(2)170-184
12 WM Hassan MS Bakry HM Hassan et al
Incidence of orbital conjunctival and
lacrimal gland malignant tumors in USA
from Surveillance Epidemiology and End
Results 1973-2009 Int J Ophthalmol
20169(12)1808-1813
13 Ajay A Rao John H Naheedy James Y-Y
Chen et al A Clinical Update and
Radiologic Review of Pediatric Orbital
and Ocular Tumors Journal of Oncology
2013(9)975908
14 Sullivan TJ Whitehead K Williamson R
et al Lymphoproliferative disease of the
ocular adnexa a clinical and pathologic
study with statistical analysis of 69
patients Ophthal Plast Reconstr Surg
200521177-188
15 Tanenbaum RE Galor A Dubovy SR et al
Classification diagnosis and management
of conjunctival lymphoma Eye Vis (Lond)
2019622
16 Olga Klavdianou Georgios Kondylis
Vasileios Georgopoulos et al Bilateral
benign reactive lymphoid hyperplasia of
the conjunctiva a case treated with oral
doxycycline and review of the literature
Eye Vis (Lond) 2019626
17 İncesoy-Ouml zdemir S Yuumlksek N Bozkurt C
et al A rare type of cancer in children
extranodal marginal zone B-cell (MALT)
lymphoma of the ocular adnexa Turk J
Pediatr 201456(3)295-298
18 Lynn J Poole Perry Frederick A Jakobiec
Peter A D Rubin Conjunctival Pediatric
Follicular Lymphoma Arch Ophthalmol
2012130(7)941-943
19 Abdullah Al-Mujaini Upender Wali
Anuradha Ganesh1 et al Ocular Adnexal
Reactive Lymphoid Hyperplasia in
Children Middle East Afr J Ophthalmol
201219(4)406-409
20 McLeod SD Edward DP Benign
lymphoid hyperplasia of the conjunctiva in
children Arch Ophthalmol
1999117(6)832-835
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
116
FIGURES
Figure 1 Slit lamp image of a mass lesion at the patientrsquos left eye caruncle for one month
Figure 2 One month after the first excision a protruding mass recurred at the patientrsquos nasal canthus
of left eye It partially involved beyond the gray line of nasal part lower eyelid
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
117
Figure 3 Histomorphology analysis and immunohistochemistry study of the caruncular lesion Abun-
dant atypical lymphoid proliferation presented in low-power photomicrograph (A) and
high-power photomicrograph (B) under hematoxylin-eosin staining The lymphoid aggrega-
tion was composed predominantly of CD20-positive cells (C) and focal positive staining of
CD3 (D)
Figure 4 Non-contrast orbital computed tomography showed a lesion of soft tissue density at medial
canthus of left orbit without obvious nasolacrimal duct or bony invasion (A) Magnetic reso-
nance imaging with contrast showed strong enhancement at left medial canthus region (B)
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
118
Figure 5 The follow-up photo were taken at three months after the second excision showing no signs
of recurrence
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
119
Juvenile Caruncular Atypical Lymphoid Proliferation ndash A Rare Case Report
罕見病例報告mdash青少年之淚阜非典型淋巴增生
施驊瑋 1林友祺 1
中文摘要
淚阜病灶相當罕見大部分為良性病灶眼睛及附屬結構淋巴增生疾病為其
鑑別診斷之一非常少見於年輕人或兒童我們報告一位 16歲的健康男性因
左眼淚阜無痛性腫塊接受切除手術卻於術後一個月復發執行第二次切除手術
後門診追蹤十個月未再復發此案例表現了部分良性與部分惡性腫瘤的特徵
我們針對反應性淋巴增生眼睛及附屬結構淋巴癌兩個疾病做討論及文獻回顧
關鍵字淚阜病灶眼睛及附屬結構淋巴增生疾病眼睛及附屬結構淋巴癌反
應性淋巴增生非典型淋巴增生
1 新光吳火獅紀念醫院眼科
通訊作者林友祺 電子信箱 yuchi067gmailcom
Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh 120
Submitted March 26 2020
Final version accepted April 16
2020
Case Report
Hyperacute intramembranous hemor-
rhage after burr hole craniostomy for
chronic subdural hematoma
Cite as Meng-Chi Lin Jui-Ming
Sun Yu-Hao Chen Cheng-Ta
Hsieh
Hyperacute intramembranous
hemorrhage after burr hole crani-
ostomy for chronic subdural he-
matoma Fu-Jen Journal of Medi-
cine 3(4) 120-125 2020
DOI
103966181020932020091803004
Meng-Chi Lin1 Jui-Ming Sun23 Yu-Hao Chen24 Cheng-Ta
Hsieh567
1Department of Surgery Zuoying Branch Kaohsiung Armed Forces
General Hospital Kaohsiung 813 Taiwan 2Section of Neurosurgery Department of Surgery Chia-Yi Christian
Hospital Chia-Yi City 600 Taiwan 3Department of Biotechnology Asia University Taichung City 41354
Taiwan 4Chung-Jen Junior College of Nursing Health Sciences and Manage-
ment Chia-Yi Country 62241 Taiwan 5Division of Neurosurgery Department of Surgery Sijhih Cathay Gen-
eral Hospital New Taipei City 22174 Taiwan 6Department of Medicine School of Medicine Fu Jen Catholic Univer-
sity New Taipei City 24205 Taiwan 7Department of Neurological Surgery Tri-Service General Hospital
National Defense Medical Center Taipei 114 Taiwan
Corresponding author E-mail address
nogormail2000comtw (Cheng-Ta Hsieh)
ABSTRACT
Burr hole craniostomy with closed-system drainage is an effective and common neurosurgical procedure to manage chronic subdural hematoma Postoperative hem-orrhage a well-known but infrequent complication may result in increased neurolog-ical deficits However hyperacute intramembranous hemorrhage within the inner and outer membrane of hematoma after burr hole craniostomy with irrigation and closed-system drainage has not been described previously Herein we report a case of postoperative spontaneous hyperacute intramembranous hemorrhage after burr hole craniostomy with closed-system drainage to manage a chronic subdural hematoma we subsequently discuss the possible pathophysiological mechanisms and review the relevant literature
Keywords Chronic subdural hematoma acute subdural hematoma bleeding burr hole craniostomy
drainage
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of Medicine V
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perative photo
(white arrow)
ntal region to
Vol 3 No 4 2
Acute intram
Yu-Hao Chen
o revealing ac
) and inner m
the previous b
2020
membranous
Cheng-Ta Hs
cute intramem
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Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh
125
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
慢性硬腦膜下出血進行鑽顱引流手術造成超急性夾膜內出
血
林孟楫 1孫瑞明 23陳昱豪 24謝政達 567
中文摘要
鑽顱併封閉系統引流手術是治療慢性硬腦膜下出血患者一種有效且常見的
神經外科手術方式術後出血可能導致神經功能缺損惡化是眾所周知但不常見
的併發症之一然而至今仍未有鑽孔併封閉系統引流造成原本慢性硬腦膜血
塊內膜和外膜間急性夾膜間出血案例在這裡我們報告一例慢性硬腦膜下出
血病患者接受鑽顱併封閉系統引流手術治療造成術後急性夾膜間出血我們在
本文中討論可能的致病機制並回顧相關文獻
關鍵字慢性硬腦膜下出血急性硬腦膜下出血出血鑽顱術引流
1國軍高雄總醫院左營分院 外科部
2崇仁醫護管理專科學校
3亞洲大學 生物科技學系
4戴德森醫療財團法人嘉義基督教醫院 外科部 神經外科
5汐止國泰綜合醫院 神經外科
6輔仁大學 醫學系
7 國防醫學院 三軍總醫院 神經外科
通訊作者謝政達 電子信箱 nogormail2000comtw
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
126
Submitted January 21 2020
Final version accepted July 08
2020
Case Report
Hamartoma of the breast A case report
Cite as Hsuan-An Chen
Cheng-Yu Lo Shih-Hung Huang
Chin-Lung Lin
Hamartoma of the breast A case
report Fu-Jen Journal of Medicine
3(5) 126-130 2020
DOI
103966181020932020091803005
Hsuan-An Chen1 Cheng-Yu Lo
3 Shih-Hung Huang
3 Chin-Lung
Lin2
1Department of Surgery Cathay General Hospital Taipei Taiwan
2Department of General Surgery Cathay General Hospital Taipei Tai-
wan
3Department of Pathology Cathay General Hospital Taipei Taiwan
Corresponding author E-mail address
lungyungmailcom (Chin-Lung Lin)
ABSTRACT
Breast hamartoma is an uncommon benign tumor rarely associated with malignancy An
excision and histological examination is necessary for the differential diagnosis We report
a case of a 49-year-old female patient presenting with a lump in the right breast Ultrasound
examination which demonstrated a 4411 cm hypoechoic lesion with lipoma Partial mas-
tectomy was arranged and the diagnosis of a hamartoma was confirmed by the histological
examination
Keywords Breast tumor Hamartoma Ultrasound
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
127
INTRODUCTION The hamartoma is a benign tumor-like lesion
that can affect various organs of the body in-
cluding lungs kidneys skin and more rarely the
breast In 1981 the hamartomas were recognized
in the WHO classification[1] They are defined
as well-demarcated mass of mammary ducts and
lobules containing varying amounts of fibrous
and adipose tissue and producing a distinctive
mammographic image
CASE REPORT A 49 year-old female had past history of left
breast mastitis with abscess status post partial
mastectomy This time she presented to our out
patient clinic for breast examination Physical
examination revealed a painless palpable mova-
ble and painless lump at upper outer quadrant of
right breast The risk of breast cancer was not
noted and the patient did not have any family
history of breast cancer The patient also denied
any trauma history before Ultrasound examina-
tion was arranged which demonstrated a 4411
cm hypoechoic lesion with lipoma at 3 oclock 2
cm from nipple of right breast and multiple hy-
poechoic nodules of various size in both breasts
and there was no suspicious axillary lymph
nodes noted (Figure1) Surgical treatment was
arranged partial mastectomy of right breast
harmartoma was successfully performed A 32 x
31 x 21 cm tumor was completely excised
Grossly examination showed a gray to yellow
and firm to fatty The diagnosis of a hamartoma
was confirmed by the histological examination
Microscopically sections of the breast lesion
show mammary hamartoma composed of ducts
lobules with interlobular fibrous tissue and adi-
pose tissue Fibrocystic change apocrine meta-
plastic ducts and scattered foci of adenosis are
noted The overall lobulocentric architecture and
the 2-cell pattern of the epithelium are preserved
columnar cell change and focal microcalcifica-
tion are present (Figure2) Based on submitted
biopsy specimen in-situ or invasive tumor cells
are not identified
DISCUSSION Hamartoma of the breast is a benign tumor like
nodule it was also known as fibroadenolipoma
lipofibroadenoma or adenolipoma based on its
predominant components It was composed of
varying amounts of glandular adipose and fi-
brous tissue[2] Hamartomas were first described
in 1971 by Arrigoni et al in a study of 10 patients
which breast tumors clinically and grossly re-
sembled fibroadenomas[3]
A higher predominance of tumors exists in fe-
males compared with males Hamartomas are
slowly-growing lesions with the diameter rang-
ing from 2 cm to 5 cm sometimes hamartomas
can reach giant diameter [4]
The clinical diagnosis of hamartoma is based on
the findings from mammography sonography
and histology examinations The hamartomas are
usually incidentally diagnosed by the women
older than 40 year-old starting mammography
screening
On physicial examination harmatomas are usu-
ally occult painless they may be as large mo-
bile soft to firm masses[5] Ultrasound showed
well capsulated mass with echogenic rim and
internal heterogeneity Mammography exam
showed well-circumscribed round to oval
masses containing fat and soft tissue densities
with a thin radiopaque pseudocapsule The
pseudocapsule results from displacement of
breast parenchyma by the tumor [56] In Pa-
thology finding microglandular adenosis is pre-
sent in fibroadipose stroma surrounded by a thin
fibrous capsule It composed of a combination of
epithelial and stromal elements usually with
normal ducts or lobules although variations of
normal tissue may also be seen Fibroadenoli-
poma myoid hamartoma and chondrolipoma are
histological variations of hamartomas depend-
ing on the proportion of normal breast tissue
elements[7]
Malignancy associated with hamartomas are
very rare[8] However it has been reported
hamartomas develop into carcinoma Malignant
transformation can occur as a result of cellular
atypia in the epithelial component of the mass[9]
Surgical removal is the curative method for
breast hamartomas[10] Diagnostic material such
as mammography ultrasonography or core nee-
dle biopsy may not give the definitive diagnosis
Therefore surgical excision and histological
examination is necessary for differential diagno-
sis[111213]
Although it is rare hamartoma can be seen along
with malignancy as it is formed from similar
components of breast tissue Therefore careful
diagnosis and appropriate management including
surgery are required
REFERENCES 1 World Health Organization (1981)
Histological typing of breast tumors In
International histological classification of
tumors 1981 2nd ed
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
128
2 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11435ndash449
2006
3 ArrigoniMG DockertyMB JuddES
The identificationand treatment of
mammary hamartoma Surg Gynecol
Obstet1971 133 577-82
4 Sanal HT Ersoz N Altinel O Unal E Can
C Giant hamartoma of the breast Breast J
2006 12 84-85
5 Feder JM de Paredes ES Hogge JP
Wilken JJ Unusual breast lesions
radiologic-pathologic correlation
Radiographics 1999 19S11ndashS26
6 Murat A Ozdemir H Yildirim H Poyraz
AK Ozercan R Hamartoma of the breast
Australas Radiol 200751 Spec NoB37ndash
9
7 Fisher CJ Hanby AM Robinson L Millis
RR Mammary hamartoma-a review of 35
cases Histopathology 1992 20 99-106
8 Choi N Ko ES Invasive ductal carcinoma
in a mammary hamartoma case report and
review of the literature Korean J Radiol
2010 Nov-Dec11(6)687-91
9 Lee EH Wylie EJ Bourke AG Bastiaan
De Boer W Invasive ductal carcinoma
arising in a breast hamartoma two case
reports and a review of the literature Clin
Radiol 2003 58 80-3
10 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11 435 ‑449
2006
11 Coyne J Hobbs FM Boggis C Harland R
Lobular carcinoma in a mammary
hamartoma J Clin Pathol 199245936ndash
937
12 G M K Tse B K B Law T K F Ma A B W
Chan Hamartoma of the breast a
clinicopathological review J Clin Pathol
200255951ndash954
13 RAAmir SSheikh BreasthamartomaA
report of 14cases of an under-recognized
and under-reported entity International
Journal of Surgery Case Reports
22(2016)1ndash4
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
129
FIGURES
Figure 1 Ultrasound shows a 4411 cm hypoechoic lesion with lipoma at 3 oclock 2 cm from nipple
of right breast
Figure 2 Photomicrograph shows mammary hamartoma composed of ducts lobules with interlobular
fibrous tissue and adipose tissue
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
130
Hamartoma of the breast A case report
乳房錯構瘤罕見個案報告
陳宣安 1羅承裕 3黃世鴻 3林錦龍 2
中文摘要
乳房錯構瘤是一種罕見之乳房良性腫瘤切除手術及病理化驗來做鑑別診斷
我們報告一位 49歲女性以可觸摸到無痛性右側乳房腫塊為臨床表徵超音波
看到一個邊緣清楚低迴音的腫塊病患接受手術切除病灶病理診斷證實為乳
房錯構瘤
關鍵字乳房腫瘤錯構瘤超音波攝影
1國泰綜合醫院外科部
2國泰綜合醫院一般外科
3國泰綜合醫院病理科
通訊作者林錦龍 電子信箱 lungyungmailcom
Fu-Jen Journal of Medicine
Mission and Goals
The Fu-Jen Journal of Medicine (FJJM) is a peer-reviewed journal which
aims to enhance research quality of staffs in the College of Medicine Fu Jen
Catholic University The journal publishes original investigations across a
wide range of medical disciplines including original research articles in basic
and clinical sciences case reports review articles brief reports and letter
to the editor FJJM is now issued by the Center of Medical Education in the
College of Medicine Fu Jen Catholic University To promote journal quality
the manuscript submitted to FJJM after August first 2015 has to be prepared
in English to meet the international standards
Issue Date
Publication Date
Institution
December 01 2003
September 30 2020
College of Medicine Fu Jen Catholic University
Honorable publisher Han-Sun Chiang
Publisher Ping-Keung Yip
Editor-in-chief Ming-Chieh Ma
Associate Editors Yu-Wen Lin
Editors
Telephone (02) 2905-3477
Address Center for Medical Education College of Medicine Fu Jen
Catholic University
No 510 Zhongzheng Rd Xinzhuang Dist New Taipei City
24205 Taiwan
Su-Jane Wang Chi-Chung Wang Chih-Ming Ho
Yih-Jing Lee Chih-Shung Wong Tze-Wah Kao
Chi-Feng Hung Rung-Fen Feng Chee-Fah Chogn
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Hen-Hui Lien Chien-Hsiou Liu
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- 9月封面
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-
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 104
TABLE
Table 1 Incidences by Category (N=40)
CategorySAC SAC 4 SAC 3 SAC 2 SAC 1 total
Laboratory and ex-
amination events
4 10 2 0 16 (400)
Clinical care event 6 2 1 0 9 (225)
Medication event 5 0 2 0 7 (175)
Surgery-related event 1 1 2 0 4 (100)
Transfusion-related
event
1 1 0 0 2 (50)
Tube event 0 1 0 0 1 (25)
Public accident 0 0 1 0 1 (26)
Total 17 (425) 15 (375) 8 (200) 0 40 (100)
SAC 1113 Severity Assessment Code SAC
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 105
FIGURES
Figure 1 Active Failures (N=40)
16 (167)
66 (1000)
640 (150)
235 (57)
735 (200)
2435 (686)
2435 (686)
3540 (875)
438 (105)
438 (105)
738 (184)
1938 (500)
3138 (816)
3840 (950)
0 5 10 15 20 25 30 35 40
Commits WidespreadRoutine Violation
Performs Work-Around Violation
Ignored a CautionWarning
Failure to Prioritize Tasks Adequately
Wrong Choice of Action During an Operation
Inadequate Real‐Time Risk Assessment
Rushed or Delayed a Necessary Action
Breakdown in Visual Scan
Over-ControlledUnder-Controlled AircraftVehicleSystem
Unintended Operation of Equipment
Procedure Not Followed Correctly
Performance-Based Errors
Judgment and Decision Making Errors
Violations
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 106
Figure 2 Preconditions (Latent Failures or Conditions) (N=40)
14 (250)
24 (500)
48 (500)
11 (1000)
18 (125)
840 (200)
0 5 10 15 20 25 30 35 40
Seat and Restraint System Problems
Instrumentation amp Warning System Issues
Noise Interference
Environment
Physical Environment
Technological Environment
27 (286)
27 (286)
27 (286)
37 (129)
47 (511)
47 (571)
77 (1000)
24 (500)
44 (1000)
47 (571)
12 (500)
22 (1000)
27 (286)
740 (175)
0 5 10 15 20 25 30 35 40
Technical or Procedural Knowledge Not Retained After Training
InterferenceInterruption
Task OverUnder Saturation
Distraction
Negative Habit Transfer
Not Paying Attention
Complacency
Overconfidence
Physical IllnessInjury
Fatigue
Physical and Mental State
Physical Problem
State of Mind
Mental Awareness
211 (182)
311 (273)
311 (273)
411 (364)
811 (7227)
911 (818)
1140 (275)
0 5 10 15 20 25 30 35 40
Inadequate Task Delegation
TaskMission PlanningBriefingDebriefing Inadequate
Failure of CrewTeam Leadership
StandardProper Terminology Not Used
Critical Information Not Communicated
Failed to Effectively Communicate
Teamwork
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 107
Figure 3 Supervision (Direct Supervisory Chain of Command) (N=40)
Figure 4 Organization Influence (Upper-Level Management Command Level) (N=40)
114 (71)
114 (71)
214 (143)
314 (214)
1314 (929)
1440 (350)
511 (455)
511 (455)
711 (636)
1140 (275)
47 (571)
67 (857)
740 (175)
0 5 10 15 20 25 30 35 40
Selected Individual with Lack of Proficiency
Improper Role‐modeling
Failed to Provide Proper Training
Failed to IdentifyCorrect Risky or Unsafe Practices
SupervisoryCommand Oversight Inadequate
Performed Inadequate Risk Assessment ‐Formal
Selected Individual with Lack of Current or Limited Experience
Authorized Unnecessary Hazard
Allowing Unwritten Policies to Become Standard
Failure to Enforce Existing Rules
Supervisory Violations
Planned Inappropriate Operations
Inadequate Supervision
12 (500)
12 (500)
240 (50)
110 (100)
510 (500)
1040 (250)
11 (1000)
140 (25)
18 (125)
18 (125)
38 (35)
48 (500)
840 (200)
0 5 10 15 20 25 30 35 40
Organizational Over-confidence or Under-confidence in Equipment
Organizational Culture (attitude actions) Allows for Unsafe TaskMission
Purchasing or Providing Poorly Designed or Unsuitable Equipment
Organizational ProgramPolicy Risks not Adequately Assessed
Failure to Provide Adequate Manning Staffing Resources
Failure to remove inadequate worn-out equipment in timely manner
Inadequate infrastructure
Command and control resources are deficient
Failure to provide adequate operational information resources
Resource Problems
Personnel Selection amp Staffing
Policy and Process Issues
ClimateCulture Influences
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 108
Supplement Table 1- HFACS Content of Human Factor Analysis Classifi-
cation System [9] Tier main level sub-item nano code
Tier 1 Unsafe Acts
Perfor-
mance-Based
Errors
Unintended operation of equipment
Checklist not followed correctly
Procedure not followed correctly
Over-controlledunder-controlled aircraftvehiclesystem
Breakdown in visual scan
Rushed or delayed a necessary action
Judgment amp De-
cision-Making
Errors
Inadequate real‐time risk assessment
Failure to prioritize tasks adequately
Ignored a cautionwarning
Wrong choice of action during an operation
Violations
Performs work-around violation
Commits widespreadroutine violation
Extreme violation-lack of discipline
Tier 2 Preconditions
Environment
Physical environment
Environmental conditions affecting vision
Vibration effects vision or balance
Heatcold stress impairs performance
External force of object impeded an individualrsquos
movement
Lights of other vehiclevesselaircraft affected vision
Noise interference
Technological environment
Seat and restraint system problems
Instrumentation amp warning system issues
Visibility restrictions (not weather related)
Controls and switches are inadequate
Automated system creates unsafe situation
Workspace incompatible with operation
Personal equipment interference
Communication equipment inadequate
Physical and
Mental State
Physical problem
Substance effects (alcohol supplements medications
drugs)
Loss of consciousness (sudden or prolonged onset)
Physical illnessinjury
Fatigue
Inadequate adaptation to darkness
Dehydration
Body sizemovement limitations
Physical strength amp coordination (inappropriate for
task demands)
Nutritiondiet
State of mind
Psychological problem
Life stressors
Emotional state
Personality style
Overconfidence
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 109
Pressing
Complacency
Motivation
Motivational exhaustion (burnout)
Sensory misperception
Motion illusion-kinesthetic
Turning illusionbalance-vestibular
Visual illusion
Misperception of changing environment
Misinterpreted misread instrument
Misinterpretation of auditorysound cues
Spatial disorientation
Temporaltime distortion
Mental awareness
Not paying attention
Fixation
Task overunder saturation
Confusion
Negative habit transfer
Distraction
Geographically lost
Interferenceinterruption
Technical or procedural knowledge not retained after
training
Inaccurate expectation
Teamwork
Failure of crewteam leadership
Inadequate task delegation
Rankposition intimidation
Lack of assertiveness
Critical information not communicated
Standardproper terminology not used
Failed to effectively communicate
Taskmission planningbriefingdebriefing inadequate
Tier 3 Supervision
Supervisory Vio-
lations
Failure to enforce existing rules
Allowing unwritten policies to become standard
Directed individual to violate existing regulations
Authorized unqualified individuals for task
Planned Inappro-
priate Operations
Directed task beyond personnel capabilities
Inappropriate team composition
Selected individual with lack of current or limited experience
Performed inadequate risk assessment ‐formal
Authorized unnecessary hazard
Inadequate Su-
pervision
Supervisorycommand oversight inadequate
Improper role‐modeling
Failed to provide proper training
Failed to provide appropriate policyguidance
Personality conflict with supervisor
Lack of supervisory responses to critical information
Failed to identifycorrect risky or unsafe practices
Selected individual with lack of proficiency
Tier 4 Organizational
Influences
Resource Prob-
lems
Command and control resources are deficient
Inadequate infrastructure
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 110
Failure to remove inadequate worn-out equipment in timely
manner
Failure to provide adequate operational information resources
Fail to provide adequate funding
Personnel Selec-
tion amp Staffing
Personnel recruiting amp selection policies are inadequate
Failure to provide adequate manning staffing resources
Policy amp Process
Issues
Pace of ops-tempoworkload
Organizational programpolicy risks not adequately assessed
Provided inadequate procedural guidance or publications
Organizational (formal) training is inadequate or unavailable
Flawed doctrinephilosophy
Inadequate program management
Purchasing or providing poorly designed or unsuitable equip-
ment
ClimateCulture
Influences
Organizational culture (attitude actions) allows for unsafe
taskmission
Organizational over-confidence or under-confidence in equip-
ment
Unit missionaircraftvehicleequipment change or unit deacti-
vation
Organizational structure is unclear or inadequate
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 111
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
以 HFACS重新檢視根本原因分析案例挖掘造成醫療不良
事件之人為因素
鄭伃洵 1洪聖惠 12柯彤文 3王拔群 14
中文摘要
背景醫療不良事件(AMEs)的管理是促進病人安全的基石根本原因分析
(RCA)是探討重大病人安全不良事件問題但是由於無法解釋更廣泛的因素而受
到限制本研究使用人為因素分類與分析工具(HFACS)回溯審視醫療不良事件
以了解影響醫療不良事件的人為因素及各層面中錯誤原因之分佈或系統性問題
方法本研究回溯 2012-2016年間有做過根本原因分析之醫療不良事件以連續
性取樣方式(continuous sampling)收集 40例醫療不良事件以人為因素分類與分
析工具(HFACS)去系統性的挖掘每件案例發生錯誤之原因結果在行為層面中
分析結果主要為基礎技能錯誤(95)判斷和決策錯誤(875)其中在基礎技能
錯誤當中以未依程序作業執行(816)及未如預期設備操作(50)佔多數判斷和
決策錯誤中以現場風險評估不確實(686)及採取錯的步驟行為(686)佔多數
而在先決條件層面中以團隊合作(275)為主要因素包含溝通不良(818)及重
要訊息未以正確的方式即時傳達(727)佔多數在監督層面當中以監督不周
(929)或監督不妥當(929)為主要因素在組織政策和流程方面(50)以組織
系統的政策風險未充分評估(35)為主要因素結論本研究進一步了解醫療不
良事件在過去使用根本原因分析未探討到的人為因素反映出潛在的監督組織
行為或系統性的問題促進病人安全預防錯誤再發生
關鍵字病人安全醫療不良事件根本原因分析人為因素
1國泰醫療財團法人國泰綜合醫院 品質管理部
2國立臺灣大學健康政策與管理研究所
3振興醫療財團法人振興醫院 醫療品質管理中心
4輔仁大學醫學院
通訊作者王拔群 電子信箱 drtonyseednettw
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin 112
Submitted January 20 2020
Final version accepted April13
2020
Case Report
Juvenile Caruncular Atypical Lymphoid
Proliferation ndash A Rare Case Report
Cite as Hua-Wei Shih Yu-Chi Lin
Juvenile Caruncular Atypical
Lymphoid Proliferation ndash A Rare
Case Report Fu-Jen Journal of
Medicine 3(3) 112-119 2020
DOI
103966181020932020091803003
Hua-Wei Shih1 Yu-Chi Lin
1
1Department of Ophthalmology Shin Kong Wu Ho-Su Memorial Hos-
pital Taipei City Taiwan
Corresponding author E-mail address
yuchi067gmailcom (Yu-Chi Lin)
ABSTRACT
Lesions of the caruncle are very rare Most caruncular lesions are benign though there were still few reported malignant lesions Ocular adnexal lymphoproliferative disease (OALD) one of the differential diagnosis of caruncular lesion is seldom seen in young pa-tient In this article we report a 16-year-old boy with recurrent caruncular atypical lym-phoid proliferation We discuss the epidemiology clinical features images histomorpholo-gy and treatment between ocular adnexal lymphomas (OAL) and reactive lymphoid hyper-plasia (RLH)
Keywords caruncular lesion ocular adnexal lymphoproliferative disease ocular adnexal lymphoma
reactive lymphoid hyperplasia atypical lymphoid proliferation
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
113
INTRODUCTION Lesions of the caruncle are very rare Differen-
tial diagnosis includes nevus myeloproliferative
disorders tumors inflammation infection cysts
vascular lesions and fibrous Biopsy is essential
for diagnosis Levy J et al reported ocular ad-
nexal lymphoproliferative disease (OALD) was
relatively uncommon diagnosis among caruncu-
lar lesions [1]
OALD was seldom described in Asian popula-
tion especially for young age C-Y Cheng re-
ported age-standardized incidence of ocular
adnexal lymphomas (OAL) in Taiwan from 1979
to 1996 was below 07 per million per year and
mean age was 531 years old [2] In 2015 five
Taiwanese cases of OAL whose age ranging
from 45 to 64 were presented [3] However
there were few cases of conjunctival OAL or
RLH in Chinese pediatric patient
Here we present a case of 16-year-old boy with a
caruncular mass at his left eye with recurrence
one month after excision We describe his clini-
cal symptoms photographs pathological results
management and follow-up clinical course in
this report
CASE REPORT A 16-year-old healthy boy presented a mass
lesion at his left eye caruncle accompanied with
the symptom of tearing for one month (Figure 1)
He had no ocular pain no itchiness no blurred
vision no night sweating no fever and no body
weight loss The patient denied systemic diseas-
es and histories of surgery His bilateral best
corrected visual acuity (BCVA) were 66 and
intraocular pressure (IOP) were both within
normal range There were no remarkable find-
ings for his cornea lens fundus and physical
examination Excision was performed and the
mass was soft with fluid inside therefore con-
junctival pyogenic cyst was our initial diagnosis
However one month after the excision a pro-
truding mass recurred at the patientrsquos nasal can-
thus of left eye (Figure 2) There were some
differences compared to previous condition At
the first time the soft mass was contained in a
well-defined cyst wall which more favored py-
ogenic granulation However after short period
of recurrence solid consistency and unclear
margin were found which favored malignancy
Besides the mass partially involved beyond the
gray line of nasal part lower eyelid whereas last
time the cyst mainly extended from conjunctiva
of caruncle The second excisional biopsy was
performed Pathologic examination demonstrat-
ed abundant atypical lymphoid proliferation
(Figure 3A 3B) Immunohistochemical studies
showed that the lymphoid aggregation was
composed predominantly of CD20-positive cells
(Figure 3C) focal positive staining of CD3
(Figure 3D) CD5 CD23 CD10 and negative
staining of cyclin-D1 Unfortunately the cellular
morphology was difficult to be evaluated due to
marked crushing artifact Thus malignant lym-
phoma cannot be excluded totally
Orbital computed tomography (CT) showed a
lesion of soft tissue density at medial canthus of
left orbit without obvious nasolacrimal duct or
bony invasion (Figure 4A) Magnetic resonance
imaging (MRI) with contrast showed strong
enhancement at left medial canthus region (Fig-
ure 4B) There was no remarkable finding in the
systemic workup including complete blood
count and differential count biochemical pro-
files and 18F-fluoro-2-deoxyglucose positron
emission tomographycomputed tomography
(18F-FDG PETCT) indicating no evidence of
systemic involvement
After the second excision we preferred con-
servative management for him due to the uncer-
tainty of malignancy and to avoid side effects
from aggressive treatment No sign of recurrence
was noted after 10 months of observation The
follow-up photo was taken at three months after
the second operation (Figure 5)
DISCUSSION Ocular adnexal lymphoproliferative disease
(OALD) consists of the spectrum of lymphoid
disease affecting the tissues surrounding the eye
including ocular adnexal lymphomas (OAL) and
lymphoid hyperplasia (LH) [4] The conjunctiva
is an important location for extranodal lympho-
ma development which comprises 25 of OAL
[5]
OAL can be grouped into two categories based
on their appearance of cells under the micro-
scope low-grade and high-grade [6] Extranodal
marginal zone lymphoma of mucosa-associated
lymphoid tissue (EMZLMALT) is the most
common subtype of OAL followed by follicular
lymphoma [7-9] Both of the above are
low-grade lymphomas
LH can be further divided by histopathology into
reactive lymphoid hyperplasia (RLH) and atypi-
cal lymphoid hyperplasia (ALH) RLH has to-
tally benign morphology and immunophenotype
whereas ALH has borderline lesions between
RLH and lymphoma [10] OAL and LH are
mostly seen in patients with age between 50-70
years old There are rare cases in pediatric group
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
114
[71011] In the C-Y Chengrsquos statistical report of
OAL in Taiwan only 8 patients were younger
than 15 years old among the 101 cases of ocular
lymphoma [2] According to an US study inci-
dence rates of OAL were analyzed in different
age groups the group of age over 50 had the
highest incidence rate of 574 per million per-
son-years while the 0-19 age group had the
lowest incidence rate of 009 per million per-
son-years [12] The incidence of LH was even
less than OAL [13]
Patients with OALD may be asymptomatic or
with symptoms of proptosis eyelid swelling a
palpable painless mass or conjunctival salmon
patch Diplopia visual loss pain or inflamma-
tion occurred less frequently implying more
aggressive features [714]
Orbital LH is not distinguishable from low-grade
lymphoma radiologically They both typically
present a round or lobulated mass that diffusely
moderately enhances with contrast and usually
shows homogenous hypointense or isointense to
muscle barely invasion to bone or nervous sys-
tem [10] Atypical appearances including inho-
mogeneous calcification or bony changes may
be seen in high-grade lymphoma case reports
such as ocular adnexal diffuse large B-cell lym-
phoma (DLBCL) which is one of the more ag-
gressive type of OAL [7] Whole body PET is
used for not only the evaluation of systemic
involvement but also the standard for staging
lymphoma Our patientrsquos image studies revealed
neither obvious local invasion nor systemic ma-
lignancy indicating high-grade lymphoma was
less likely Low-grade lymphoma and benign
reactive lymphoid hyperplasia were still under
consideration
Histomorphology analysis and immunohisto-
chemistry (IHC) are essential for diagnosis
Flow cytometry and polymerase chain reaction
(PCR) technique are also applied to help differ-
entiate from RLH and OAL [1016] Our case
had immunohistochemical profile of positivity
for CD20 predominantly positivity focally for
CD3 CD5 CD10 CD23 and negativity for cy-
clin-D1 BCL-6 staining was not performed in
our casersquos biopsy Thus according to the IHC
report RLH ALH and follicular lymphoma are
probable diagnosis of our patient
Radiation therapy is the standard treatment for
low-grade OAL that is classified as T1N0M0 or
T2N0M0 according to the AJCC criteria [15]
İncesoy-Ouml zdemir S et al reported a 10-year-old
boy diagnosed of MALT lymphoma who was
treated with local radiotherapy (36 Gy) and
there were no local or systemic recurrences dur-
ing his nearly four-year follow-up [17] Another
case report represented a 21-year-old man of
conjunctival follicular lymphoma treated with
surgical excision only showing no evidence of
recurrence after 8 months follow-up [18] Other
treatment options for pediatric and juvenile OAL
were performed in some case reports including
intravenous rituximab intralesional interfer-
on-α-2b topical interferon a6 systemic doxycy-
cline surgical excision and postoperative local
cryotherapy [15]
Treatment for young conjunctival RLH was less
discussed in the past In a case series article
three children (9 13 14 years old respectively)
of RLH received surgical resection without fur-
ther postoperative management and no signs of
recurrence were noted during follow-up [19]
Short-term topical and oral corticosteroids after
surgical excision were prescribed in two pediat-
ric RLH patients for their small residual mass
However poor response in both cases was nota-
ble [20]
Our patient declined to receive radiotherapy or
any further postoperative treatment mainly due
to his concerning of possible side effects (such
as dry eye and cataract)
CONCLUSION We present a rare case of caruncle mass in this
report OALD is one of the relatively uncommon
diagnosis among caruncular lesions OALD
includes benign RLH and malignant OAL
which are both mainly seen in elderly patients
even rarer in pediatric or juvenile group
The standard treatment for low-grade OAL and
RLH in young patents are still debatable How-
ever long-term follow-up is suggested for both
OAL and RLH patients Though RLH has a be-
nign and self-limited course risk of malignant
transformation is possible
REFERENCES 1 Levy J Ilsar M Deckel Y et al Lesions of
the caruncle a description of 42 cases and
a review of the literature Eye
200923(5)1004-1018
2 C-Y Cheng and W-M Hsu Incidence of
eye cancer in Taiwan an 18-year review
Eye 200418152-158
3 Chui-Lien Tsen Muh-Chiou Lin
Youn-Shen Bee et al Ocular adnexal
lymphoma Five case reports and a
literature review Taiwan Journal of
Ophthalmology 20155(2)99-102
4 Liesegang TJ Ocular adnexal
lymphoproliferative lesions Mayo Clin
Proc 199368(10)1003-1010
5 Kirkegaard MM Coupland SE Prause JU
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
115
et al Malignant lymphoma of the
conjunctiva Surv Ophthalmol
201560(5)444-458
6 Stacy RC Jakobiec FA Schoenfield L et
al Unifocal and multifocal reactive
lymphoid hyperplasia vs follicular
lymphoma of the ocular adnexa Am J
Ophthalmol 2010150(3)412-426
7 Sullivan TJ Ocular Adnexal
Lymphoproliferative Disease In Guthoff
RF Katowitz JA eds Oculoplastics and
Orbit Berlin Heidelberg Springer
20101-19
8 White Valerie A Understanding and
Classification of Ocular Lymphomas
Ocular Oncology and Pathology
20195379-386
9 Stefanovic A Lossos IS Extranodal
marginal zone lymphoma of the ocular
adnexa Blood 2009114(3)501-510
10 Andrew NH Coupland SE Pirbhai A et al
Lymphoid hyperplasia of the orbit and
ocular adnexa A clinical pathologic review
Surv Ophthalmol 201661(6)778-790
11 Ferry JA1 Fung CY Zukerberg L et al
Lymphoma of the ocular adnexa A study
of 353 cases Am J Surg Pathol
200731(2)170-184
12 WM Hassan MS Bakry HM Hassan et al
Incidence of orbital conjunctival and
lacrimal gland malignant tumors in USA
from Surveillance Epidemiology and End
Results 1973-2009 Int J Ophthalmol
20169(12)1808-1813
13 Ajay A Rao John H Naheedy James Y-Y
Chen et al A Clinical Update and
Radiologic Review of Pediatric Orbital
and Ocular Tumors Journal of Oncology
2013(9)975908
14 Sullivan TJ Whitehead K Williamson R
et al Lymphoproliferative disease of the
ocular adnexa a clinical and pathologic
study with statistical analysis of 69
patients Ophthal Plast Reconstr Surg
200521177-188
15 Tanenbaum RE Galor A Dubovy SR et al
Classification diagnosis and management
of conjunctival lymphoma Eye Vis (Lond)
2019622
16 Olga Klavdianou Georgios Kondylis
Vasileios Georgopoulos et al Bilateral
benign reactive lymphoid hyperplasia of
the conjunctiva a case treated with oral
doxycycline and review of the literature
Eye Vis (Lond) 2019626
17 İncesoy-Ouml zdemir S Yuumlksek N Bozkurt C
et al A rare type of cancer in children
extranodal marginal zone B-cell (MALT)
lymphoma of the ocular adnexa Turk J
Pediatr 201456(3)295-298
18 Lynn J Poole Perry Frederick A Jakobiec
Peter A D Rubin Conjunctival Pediatric
Follicular Lymphoma Arch Ophthalmol
2012130(7)941-943
19 Abdullah Al-Mujaini Upender Wali
Anuradha Ganesh1 et al Ocular Adnexal
Reactive Lymphoid Hyperplasia in
Children Middle East Afr J Ophthalmol
201219(4)406-409
20 McLeod SD Edward DP Benign
lymphoid hyperplasia of the conjunctiva in
children Arch Ophthalmol
1999117(6)832-835
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
116
FIGURES
Figure 1 Slit lamp image of a mass lesion at the patientrsquos left eye caruncle for one month
Figure 2 One month after the first excision a protruding mass recurred at the patientrsquos nasal canthus
of left eye It partially involved beyond the gray line of nasal part lower eyelid
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
117
Figure 3 Histomorphology analysis and immunohistochemistry study of the caruncular lesion Abun-
dant atypical lymphoid proliferation presented in low-power photomicrograph (A) and
high-power photomicrograph (B) under hematoxylin-eosin staining The lymphoid aggrega-
tion was composed predominantly of CD20-positive cells (C) and focal positive staining of
CD3 (D)
Figure 4 Non-contrast orbital computed tomography showed a lesion of soft tissue density at medial
canthus of left orbit without obvious nasolacrimal duct or bony invasion (A) Magnetic reso-
nance imaging with contrast showed strong enhancement at left medial canthus region (B)
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
118
Figure 5 The follow-up photo were taken at three months after the second excision showing no signs
of recurrence
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
119
Juvenile Caruncular Atypical Lymphoid Proliferation ndash A Rare Case Report
罕見病例報告mdash青少年之淚阜非典型淋巴增生
施驊瑋 1林友祺 1
中文摘要
淚阜病灶相當罕見大部分為良性病灶眼睛及附屬結構淋巴增生疾病為其
鑑別診斷之一非常少見於年輕人或兒童我們報告一位 16歲的健康男性因
左眼淚阜無痛性腫塊接受切除手術卻於術後一個月復發執行第二次切除手術
後門診追蹤十個月未再復發此案例表現了部分良性與部分惡性腫瘤的特徵
我們針對反應性淋巴增生眼睛及附屬結構淋巴癌兩個疾病做討論及文獻回顧
關鍵字淚阜病灶眼睛及附屬結構淋巴增生疾病眼睛及附屬結構淋巴癌反
應性淋巴增生非典型淋巴增生
1 新光吳火獅紀念醫院眼科
通訊作者林友祺 電子信箱 yuchi067gmailcom
Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh 120
Submitted March 26 2020
Final version accepted April 16
2020
Case Report
Hyperacute intramembranous hemor-
rhage after burr hole craniostomy for
chronic subdural hematoma
Cite as Meng-Chi Lin Jui-Ming
Sun Yu-Hao Chen Cheng-Ta
Hsieh
Hyperacute intramembranous
hemorrhage after burr hole crani-
ostomy for chronic subdural he-
matoma Fu-Jen Journal of Medi-
cine 3(4) 120-125 2020
DOI
103966181020932020091803004
Meng-Chi Lin1 Jui-Ming Sun23 Yu-Hao Chen24 Cheng-Ta
Hsieh567
1Department of Surgery Zuoying Branch Kaohsiung Armed Forces
General Hospital Kaohsiung 813 Taiwan 2Section of Neurosurgery Department of Surgery Chia-Yi Christian
Hospital Chia-Yi City 600 Taiwan 3Department of Biotechnology Asia University Taichung City 41354
Taiwan 4Chung-Jen Junior College of Nursing Health Sciences and Manage-
ment Chia-Yi Country 62241 Taiwan 5Division of Neurosurgery Department of Surgery Sijhih Cathay Gen-
eral Hospital New Taipei City 22174 Taiwan 6Department of Medicine School of Medicine Fu Jen Catholic Univer-
sity New Taipei City 24205 Taiwan 7Department of Neurological Surgery Tri-Service General Hospital
National Defense Medical Center Taipei 114 Taiwan
Corresponding author E-mail address
nogormail2000comtw (Cheng-Ta Hsieh)
ABSTRACT
Burr hole craniostomy with closed-system drainage is an effective and common neurosurgical procedure to manage chronic subdural hematoma Postoperative hem-orrhage a well-known but infrequent complication may result in increased neurolog-ical deficits However hyperacute intramembranous hemorrhage within the inner and outer membrane of hematoma after burr hole craniostomy with irrigation and closed-system drainage has not been described previously Herein we report a case of postoperative spontaneous hyperacute intramembranous hemorrhage after burr hole craniostomy with closed-system drainage to manage a chronic subdural hematoma we subsequently discuss the possible pathophysiological mechanisms and review the relevant literature
Keywords Chronic subdural hematoma acute subdural hematoma bleeding burr hole craniostomy
drainage
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2020
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Cheng-Ta Hs
cute intramem
membrane (wh
burr hole cran
hemorrhage
ieh
mbranous hem
hite asterisk) o
niostomy site
morrhage withi
of the hemato
(white triangl
in the outer m
oma situated
le)
124
mem-
from
Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh
125
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
慢性硬腦膜下出血進行鑽顱引流手術造成超急性夾膜內出
血
林孟楫 1孫瑞明 23陳昱豪 24謝政達 567
中文摘要
鑽顱併封閉系統引流手術是治療慢性硬腦膜下出血患者一種有效且常見的
神經外科手術方式術後出血可能導致神經功能缺損惡化是眾所周知但不常見
的併發症之一然而至今仍未有鑽孔併封閉系統引流造成原本慢性硬腦膜血
塊內膜和外膜間急性夾膜間出血案例在這裡我們報告一例慢性硬腦膜下出
血病患者接受鑽顱併封閉系統引流手術治療造成術後急性夾膜間出血我們在
本文中討論可能的致病機制並回顧相關文獻
關鍵字慢性硬腦膜下出血急性硬腦膜下出血出血鑽顱術引流
1國軍高雄總醫院左營分院 外科部
2崇仁醫護管理專科學校
3亞洲大學 生物科技學系
4戴德森醫療財團法人嘉義基督教醫院 外科部 神經外科
5汐止國泰綜合醫院 神經外科
6輔仁大學 醫學系
7 國防醫學院 三軍總醫院 神經外科
通訊作者謝政達 電子信箱 nogormail2000comtw
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
126
Submitted January 21 2020
Final version accepted July 08
2020
Case Report
Hamartoma of the breast A case report
Cite as Hsuan-An Chen
Cheng-Yu Lo Shih-Hung Huang
Chin-Lung Lin
Hamartoma of the breast A case
report Fu-Jen Journal of Medicine
3(5) 126-130 2020
DOI
103966181020932020091803005
Hsuan-An Chen1 Cheng-Yu Lo
3 Shih-Hung Huang
3 Chin-Lung
Lin2
1Department of Surgery Cathay General Hospital Taipei Taiwan
2Department of General Surgery Cathay General Hospital Taipei Tai-
wan
3Department of Pathology Cathay General Hospital Taipei Taiwan
Corresponding author E-mail address
lungyungmailcom (Chin-Lung Lin)
ABSTRACT
Breast hamartoma is an uncommon benign tumor rarely associated with malignancy An
excision and histological examination is necessary for the differential diagnosis We report
a case of a 49-year-old female patient presenting with a lump in the right breast Ultrasound
examination which demonstrated a 4411 cm hypoechoic lesion with lipoma Partial mas-
tectomy was arranged and the diagnosis of a hamartoma was confirmed by the histological
examination
Keywords Breast tumor Hamartoma Ultrasound
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
127
INTRODUCTION The hamartoma is a benign tumor-like lesion
that can affect various organs of the body in-
cluding lungs kidneys skin and more rarely the
breast In 1981 the hamartomas were recognized
in the WHO classification[1] They are defined
as well-demarcated mass of mammary ducts and
lobules containing varying amounts of fibrous
and adipose tissue and producing a distinctive
mammographic image
CASE REPORT A 49 year-old female had past history of left
breast mastitis with abscess status post partial
mastectomy This time she presented to our out
patient clinic for breast examination Physical
examination revealed a painless palpable mova-
ble and painless lump at upper outer quadrant of
right breast The risk of breast cancer was not
noted and the patient did not have any family
history of breast cancer The patient also denied
any trauma history before Ultrasound examina-
tion was arranged which demonstrated a 4411
cm hypoechoic lesion with lipoma at 3 oclock 2
cm from nipple of right breast and multiple hy-
poechoic nodules of various size in both breasts
and there was no suspicious axillary lymph
nodes noted (Figure1) Surgical treatment was
arranged partial mastectomy of right breast
harmartoma was successfully performed A 32 x
31 x 21 cm tumor was completely excised
Grossly examination showed a gray to yellow
and firm to fatty The diagnosis of a hamartoma
was confirmed by the histological examination
Microscopically sections of the breast lesion
show mammary hamartoma composed of ducts
lobules with interlobular fibrous tissue and adi-
pose tissue Fibrocystic change apocrine meta-
plastic ducts and scattered foci of adenosis are
noted The overall lobulocentric architecture and
the 2-cell pattern of the epithelium are preserved
columnar cell change and focal microcalcifica-
tion are present (Figure2) Based on submitted
biopsy specimen in-situ or invasive tumor cells
are not identified
DISCUSSION Hamartoma of the breast is a benign tumor like
nodule it was also known as fibroadenolipoma
lipofibroadenoma or adenolipoma based on its
predominant components It was composed of
varying amounts of glandular adipose and fi-
brous tissue[2] Hamartomas were first described
in 1971 by Arrigoni et al in a study of 10 patients
which breast tumors clinically and grossly re-
sembled fibroadenomas[3]
A higher predominance of tumors exists in fe-
males compared with males Hamartomas are
slowly-growing lesions with the diameter rang-
ing from 2 cm to 5 cm sometimes hamartomas
can reach giant diameter [4]
The clinical diagnosis of hamartoma is based on
the findings from mammography sonography
and histology examinations The hamartomas are
usually incidentally diagnosed by the women
older than 40 year-old starting mammography
screening
On physicial examination harmatomas are usu-
ally occult painless they may be as large mo-
bile soft to firm masses[5] Ultrasound showed
well capsulated mass with echogenic rim and
internal heterogeneity Mammography exam
showed well-circumscribed round to oval
masses containing fat and soft tissue densities
with a thin radiopaque pseudocapsule The
pseudocapsule results from displacement of
breast parenchyma by the tumor [56] In Pa-
thology finding microglandular adenosis is pre-
sent in fibroadipose stroma surrounded by a thin
fibrous capsule It composed of a combination of
epithelial and stromal elements usually with
normal ducts or lobules although variations of
normal tissue may also be seen Fibroadenoli-
poma myoid hamartoma and chondrolipoma are
histological variations of hamartomas depend-
ing on the proportion of normal breast tissue
elements[7]
Malignancy associated with hamartomas are
very rare[8] However it has been reported
hamartomas develop into carcinoma Malignant
transformation can occur as a result of cellular
atypia in the epithelial component of the mass[9]
Surgical removal is the curative method for
breast hamartomas[10] Diagnostic material such
as mammography ultrasonography or core nee-
dle biopsy may not give the definitive diagnosis
Therefore surgical excision and histological
examination is necessary for differential diagno-
sis[111213]
Although it is rare hamartoma can be seen along
with malignancy as it is formed from similar
components of breast tissue Therefore careful
diagnosis and appropriate management including
surgery are required
REFERENCES 1 World Health Organization (1981)
Histological typing of breast tumors In
International histological classification of
tumors 1981 2nd ed
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
128
2 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11435ndash449
2006
3 ArrigoniMG DockertyMB JuddES
The identificationand treatment of
mammary hamartoma Surg Gynecol
Obstet1971 133 577-82
4 Sanal HT Ersoz N Altinel O Unal E Can
C Giant hamartoma of the breast Breast J
2006 12 84-85
5 Feder JM de Paredes ES Hogge JP
Wilken JJ Unusual breast lesions
radiologic-pathologic correlation
Radiographics 1999 19S11ndashS26
6 Murat A Ozdemir H Yildirim H Poyraz
AK Ozercan R Hamartoma of the breast
Australas Radiol 200751 Spec NoB37ndash
9
7 Fisher CJ Hanby AM Robinson L Millis
RR Mammary hamartoma-a review of 35
cases Histopathology 1992 20 99-106
8 Choi N Ko ES Invasive ductal carcinoma
in a mammary hamartoma case report and
review of the literature Korean J Radiol
2010 Nov-Dec11(6)687-91
9 Lee EH Wylie EJ Bourke AG Bastiaan
De Boer W Invasive ductal carcinoma
arising in a breast hamartoma two case
reports and a review of the literature Clin
Radiol 2003 58 80-3
10 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11 435 ‑449
2006
11 Coyne J Hobbs FM Boggis C Harland R
Lobular carcinoma in a mammary
hamartoma J Clin Pathol 199245936ndash
937
12 G M K Tse B K B Law T K F Ma A B W
Chan Hamartoma of the breast a
clinicopathological review J Clin Pathol
200255951ndash954
13 RAAmir SSheikh BreasthamartomaA
report of 14cases of an under-recognized
and under-reported entity International
Journal of Surgery Case Reports
22(2016)1ndash4
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
129
FIGURES
Figure 1 Ultrasound shows a 4411 cm hypoechoic lesion with lipoma at 3 oclock 2 cm from nipple
of right breast
Figure 2 Photomicrograph shows mammary hamartoma composed of ducts lobules with interlobular
fibrous tissue and adipose tissue
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
130
Hamartoma of the breast A case report
乳房錯構瘤罕見個案報告
陳宣安 1羅承裕 3黃世鴻 3林錦龍 2
中文摘要
乳房錯構瘤是一種罕見之乳房良性腫瘤切除手術及病理化驗來做鑑別診斷
我們報告一位 49歲女性以可觸摸到無痛性右側乳房腫塊為臨床表徵超音波
看到一個邊緣清楚低迴音的腫塊病患接受手術切除病灶病理診斷證實為乳
房錯構瘤
關鍵字乳房腫瘤錯構瘤超音波攝影
1國泰綜合醫院外科部
2國泰綜合醫院一般外科
3國泰綜合醫院病理科
通訊作者林錦龍 電子信箱 lungyungmailcom
Fu-Jen Journal of Medicine
Mission and Goals
The Fu-Jen Journal of Medicine (FJJM) is a peer-reviewed journal which
aims to enhance research quality of staffs in the College of Medicine Fu Jen
Catholic University The journal publishes original investigations across a
wide range of medical disciplines including original research articles in basic
and clinical sciences case reports review articles brief reports and letter
to the editor FJJM is now issued by the Center of Medical Education in the
College of Medicine Fu Jen Catholic University To promote journal quality
the manuscript submitted to FJJM after August first 2015 has to be prepared
in English to meet the international standards
Issue Date
Publication Date
Institution
December 01 2003
September 30 2020
College of Medicine Fu Jen Catholic University
Honorable publisher Han-Sun Chiang
Publisher Ping-Keung Yip
Editor-in-chief Ming-Chieh Ma
Associate Editors Yu-Wen Lin
Editors
Telephone (02) 2905-3477
Address Center for Medical Education College of Medicine Fu Jen
Catholic University
No 510 Zhongzheng Rd Xinzhuang Dist New Taipei City
24205 Taiwan
Su-Jane Wang Chi-Chung Wang Chih-Ming Ho
Yih-Jing Lee Chih-Shung Wong Tze-Wah Kao
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- 9月封面
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-
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 105
FIGURES
Figure 1 Active Failures (N=40)
16 (167)
66 (1000)
640 (150)
235 (57)
735 (200)
2435 (686)
2435 (686)
3540 (875)
438 (105)
438 (105)
738 (184)
1938 (500)
3138 (816)
3840 (950)
0 5 10 15 20 25 30 35 40
Commits WidespreadRoutine Violation
Performs Work-Around Violation
Ignored a CautionWarning
Failure to Prioritize Tasks Adequately
Wrong Choice of Action During an Operation
Inadequate Real‐Time Risk Assessment
Rushed or Delayed a Necessary Action
Breakdown in Visual Scan
Over-ControlledUnder-Controlled AircraftVehicleSystem
Unintended Operation of Equipment
Procedure Not Followed Correctly
Performance-Based Errors
Judgment and Decision Making Errors
Violations
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 106
Figure 2 Preconditions (Latent Failures or Conditions) (N=40)
14 (250)
24 (500)
48 (500)
11 (1000)
18 (125)
840 (200)
0 5 10 15 20 25 30 35 40
Seat and Restraint System Problems
Instrumentation amp Warning System Issues
Noise Interference
Environment
Physical Environment
Technological Environment
27 (286)
27 (286)
27 (286)
37 (129)
47 (511)
47 (571)
77 (1000)
24 (500)
44 (1000)
47 (571)
12 (500)
22 (1000)
27 (286)
740 (175)
0 5 10 15 20 25 30 35 40
Technical or Procedural Knowledge Not Retained After Training
InterferenceInterruption
Task OverUnder Saturation
Distraction
Negative Habit Transfer
Not Paying Attention
Complacency
Overconfidence
Physical IllnessInjury
Fatigue
Physical and Mental State
Physical Problem
State of Mind
Mental Awareness
211 (182)
311 (273)
311 (273)
411 (364)
811 (7227)
911 (818)
1140 (275)
0 5 10 15 20 25 30 35 40
Inadequate Task Delegation
TaskMission PlanningBriefingDebriefing Inadequate
Failure of CrewTeam Leadership
StandardProper Terminology Not Used
Critical Information Not Communicated
Failed to Effectively Communicate
Teamwork
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 107
Figure 3 Supervision (Direct Supervisory Chain of Command) (N=40)
Figure 4 Organization Influence (Upper-Level Management Command Level) (N=40)
114 (71)
114 (71)
214 (143)
314 (214)
1314 (929)
1440 (350)
511 (455)
511 (455)
711 (636)
1140 (275)
47 (571)
67 (857)
740 (175)
0 5 10 15 20 25 30 35 40
Selected Individual with Lack of Proficiency
Improper Role‐modeling
Failed to Provide Proper Training
Failed to IdentifyCorrect Risky or Unsafe Practices
SupervisoryCommand Oversight Inadequate
Performed Inadequate Risk Assessment ‐Formal
Selected Individual with Lack of Current or Limited Experience
Authorized Unnecessary Hazard
Allowing Unwritten Policies to Become Standard
Failure to Enforce Existing Rules
Supervisory Violations
Planned Inappropriate Operations
Inadequate Supervision
12 (500)
12 (500)
240 (50)
110 (100)
510 (500)
1040 (250)
11 (1000)
140 (25)
18 (125)
18 (125)
38 (35)
48 (500)
840 (200)
0 5 10 15 20 25 30 35 40
Organizational Over-confidence or Under-confidence in Equipment
Organizational Culture (attitude actions) Allows for Unsafe TaskMission
Purchasing or Providing Poorly Designed or Unsuitable Equipment
Organizational ProgramPolicy Risks not Adequately Assessed
Failure to Provide Adequate Manning Staffing Resources
Failure to remove inadequate worn-out equipment in timely manner
Inadequate infrastructure
Command and control resources are deficient
Failure to provide adequate operational information resources
Resource Problems
Personnel Selection amp Staffing
Policy and Process Issues
ClimateCulture Influences
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 108
Supplement Table 1- HFACS Content of Human Factor Analysis Classifi-
cation System [9] Tier main level sub-item nano code
Tier 1 Unsafe Acts
Perfor-
mance-Based
Errors
Unintended operation of equipment
Checklist not followed correctly
Procedure not followed correctly
Over-controlledunder-controlled aircraftvehiclesystem
Breakdown in visual scan
Rushed or delayed a necessary action
Judgment amp De-
cision-Making
Errors
Inadequate real‐time risk assessment
Failure to prioritize tasks adequately
Ignored a cautionwarning
Wrong choice of action during an operation
Violations
Performs work-around violation
Commits widespreadroutine violation
Extreme violation-lack of discipline
Tier 2 Preconditions
Environment
Physical environment
Environmental conditions affecting vision
Vibration effects vision or balance
Heatcold stress impairs performance
External force of object impeded an individualrsquos
movement
Lights of other vehiclevesselaircraft affected vision
Noise interference
Technological environment
Seat and restraint system problems
Instrumentation amp warning system issues
Visibility restrictions (not weather related)
Controls and switches are inadequate
Automated system creates unsafe situation
Workspace incompatible with operation
Personal equipment interference
Communication equipment inadequate
Physical and
Mental State
Physical problem
Substance effects (alcohol supplements medications
drugs)
Loss of consciousness (sudden or prolonged onset)
Physical illnessinjury
Fatigue
Inadequate adaptation to darkness
Dehydration
Body sizemovement limitations
Physical strength amp coordination (inappropriate for
task demands)
Nutritiondiet
State of mind
Psychological problem
Life stressors
Emotional state
Personality style
Overconfidence
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 109
Pressing
Complacency
Motivation
Motivational exhaustion (burnout)
Sensory misperception
Motion illusion-kinesthetic
Turning illusionbalance-vestibular
Visual illusion
Misperception of changing environment
Misinterpreted misread instrument
Misinterpretation of auditorysound cues
Spatial disorientation
Temporaltime distortion
Mental awareness
Not paying attention
Fixation
Task overunder saturation
Confusion
Negative habit transfer
Distraction
Geographically lost
Interferenceinterruption
Technical or procedural knowledge not retained after
training
Inaccurate expectation
Teamwork
Failure of crewteam leadership
Inadequate task delegation
Rankposition intimidation
Lack of assertiveness
Critical information not communicated
Standardproper terminology not used
Failed to effectively communicate
Taskmission planningbriefingdebriefing inadequate
Tier 3 Supervision
Supervisory Vio-
lations
Failure to enforce existing rules
Allowing unwritten policies to become standard
Directed individual to violate existing regulations
Authorized unqualified individuals for task
Planned Inappro-
priate Operations
Directed task beyond personnel capabilities
Inappropriate team composition
Selected individual with lack of current or limited experience
Performed inadequate risk assessment ‐formal
Authorized unnecessary hazard
Inadequate Su-
pervision
Supervisorycommand oversight inadequate
Improper role‐modeling
Failed to provide proper training
Failed to provide appropriate policyguidance
Personality conflict with supervisor
Lack of supervisory responses to critical information
Failed to identifycorrect risky or unsafe practices
Selected individual with lack of proficiency
Tier 4 Organizational
Influences
Resource Prob-
lems
Command and control resources are deficient
Inadequate infrastructure
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 110
Failure to remove inadequate worn-out equipment in timely
manner
Failure to provide adequate operational information resources
Fail to provide adequate funding
Personnel Selec-
tion amp Staffing
Personnel recruiting amp selection policies are inadequate
Failure to provide adequate manning staffing resources
Policy amp Process
Issues
Pace of ops-tempoworkload
Organizational programpolicy risks not adequately assessed
Provided inadequate procedural guidance or publications
Organizational (formal) training is inadequate or unavailable
Flawed doctrinephilosophy
Inadequate program management
Purchasing or providing poorly designed or unsuitable equip-
ment
ClimateCulture
Influences
Organizational culture (attitude actions) allows for unsafe
taskmission
Organizational over-confidence or under-confidence in equip-
ment
Unit missionaircraftvehicleequipment change or unit deacti-
vation
Organizational structure is unclear or inadequate
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 111
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
以 HFACS重新檢視根本原因分析案例挖掘造成醫療不良
事件之人為因素
鄭伃洵 1洪聖惠 12柯彤文 3王拔群 14
中文摘要
背景醫療不良事件(AMEs)的管理是促進病人安全的基石根本原因分析
(RCA)是探討重大病人安全不良事件問題但是由於無法解釋更廣泛的因素而受
到限制本研究使用人為因素分類與分析工具(HFACS)回溯審視醫療不良事件
以了解影響醫療不良事件的人為因素及各層面中錯誤原因之分佈或系統性問題
方法本研究回溯 2012-2016年間有做過根本原因分析之醫療不良事件以連續
性取樣方式(continuous sampling)收集 40例醫療不良事件以人為因素分類與分
析工具(HFACS)去系統性的挖掘每件案例發生錯誤之原因結果在行為層面中
分析結果主要為基礎技能錯誤(95)判斷和決策錯誤(875)其中在基礎技能
錯誤當中以未依程序作業執行(816)及未如預期設備操作(50)佔多數判斷和
決策錯誤中以現場風險評估不確實(686)及採取錯的步驟行為(686)佔多數
而在先決條件層面中以團隊合作(275)為主要因素包含溝通不良(818)及重
要訊息未以正確的方式即時傳達(727)佔多數在監督層面當中以監督不周
(929)或監督不妥當(929)為主要因素在組織政策和流程方面(50)以組織
系統的政策風險未充分評估(35)為主要因素結論本研究進一步了解醫療不
良事件在過去使用根本原因分析未探討到的人為因素反映出潛在的監督組織
行為或系統性的問題促進病人安全預防錯誤再發生
關鍵字病人安全醫療不良事件根本原因分析人為因素
1國泰醫療財團法人國泰綜合醫院 品質管理部
2國立臺灣大學健康政策與管理研究所
3振興醫療財團法人振興醫院 醫療品質管理中心
4輔仁大學醫學院
通訊作者王拔群 電子信箱 drtonyseednettw
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin 112
Submitted January 20 2020
Final version accepted April13
2020
Case Report
Juvenile Caruncular Atypical Lymphoid
Proliferation ndash A Rare Case Report
Cite as Hua-Wei Shih Yu-Chi Lin
Juvenile Caruncular Atypical
Lymphoid Proliferation ndash A Rare
Case Report Fu-Jen Journal of
Medicine 3(3) 112-119 2020
DOI
103966181020932020091803003
Hua-Wei Shih1 Yu-Chi Lin
1
1Department of Ophthalmology Shin Kong Wu Ho-Su Memorial Hos-
pital Taipei City Taiwan
Corresponding author E-mail address
yuchi067gmailcom (Yu-Chi Lin)
ABSTRACT
Lesions of the caruncle are very rare Most caruncular lesions are benign though there were still few reported malignant lesions Ocular adnexal lymphoproliferative disease (OALD) one of the differential diagnosis of caruncular lesion is seldom seen in young pa-tient In this article we report a 16-year-old boy with recurrent caruncular atypical lym-phoid proliferation We discuss the epidemiology clinical features images histomorpholo-gy and treatment between ocular adnexal lymphomas (OAL) and reactive lymphoid hyper-plasia (RLH)
Keywords caruncular lesion ocular adnexal lymphoproliferative disease ocular adnexal lymphoma
reactive lymphoid hyperplasia atypical lymphoid proliferation
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
113
INTRODUCTION Lesions of the caruncle are very rare Differen-
tial diagnosis includes nevus myeloproliferative
disorders tumors inflammation infection cysts
vascular lesions and fibrous Biopsy is essential
for diagnosis Levy J et al reported ocular ad-
nexal lymphoproliferative disease (OALD) was
relatively uncommon diagnosis among caruncu-
lar lesions [1]
OALD was seldom described in Asian popula-
tion especially for young age C-Y Cheng re-
ported age-standardized incidence of ocular
adnexal lymphomas (OAL) in Taiwan from 1979
to 1996 was below 07 per million per year and
mean age was 531 years old [2] In 2015 five
Taiwanese cases of OAL whose age ranging
from 45 to 64 were presented [3] However
there were few cases of conjunctival OAL or
RLH in Chinese pediatric patient
Here we present a case of 16-year-old boy with a
caruncular mass at his left eye with recurrence
one month after excision We describe his clini-
cal symptoms photographs pathological results
management and follow-up clinical course in
this report
CASE REPORT A 16-year-old healthy boy presented a mass
lesion at his left eye caruncle accompanied with
the symptom of tearing for one month (Figure 1)
He had no ocular pain no itchiness no blurred
vision no night sweating no fever and no body
weight loss The patient denied systemic diseas-
es and histories of surgery His bilateral best
corrected visual acuity (BCVA) were 66 and
intraocular pressure (IOP) were both within
normal range There were no remarkable find-
ings for his cornea lens fundus and physical
examination Excision was performed and the
mass was soft with fluid inside therefore con-
junctival pyogenic cyst was our initial diagnosis
However one month after the excision a pro-
truding mass recurred at the patientrsquos nasal can-
thus of left eye (Figure 2) There were some
differences compared to previous condition At
the first time the soft mass was contained in a
well-defined cyst wall which more favored py-
ogenic granulation However after short period
of recurrence solid consistency and unclear
margin were found which favored malignancy
Besides the mass partially involved beyond the
gray line of nasal part lower eyelid whereas last
time the cyst mainly extended from conjunctiva
of caruncle The second excisional biopsy was
performed Pathologic examination demonstrat-
ed abundant atypical lymphoid proliferation
(Figure 3A 3B) Immunohistochemical studies
showed that the lymphoid aggregation was
composed predominantly of CD20-positive cells
(Figure 3C) focal positive staining of CD3
(Figure 3D) CD5 CD23 CD10 and negative
staining of cyclin-D1 Unfortunately the cellular
morphology was difficult to be evaluated due to
marked crushing artifact Thus malignant lym-
phoma cannot be excluded totally
Orbital computed tomography (CT) showed a
lesion of soft tissue density at medial canthus of
left orbit without obvious nasolacrimal duct or
bony invasion (Figure 4A) Magnetic resonance
imaging (MRI) with contrast showed strong
enhancement at left medial canthus region (Fig-
ure 4B) There was no remarkable finding in the
systemic workup including complete blood
count and differential count biochemical pro-
files and 18F-fluoro-2-deoxyglucose positron
emission tomographycomputed tomography
(18F-FDG PETCT) indicating no evidence of
systemic involvement
After the second excision we preferred con-
servative management for him due to the uncer-
tainty of malignancy and to avoid side effects
from aggressive treatment No sign of recurrence
was noted after 10 months of observation The
follow-up photo was taken at three months after
the second operation (Figure 5)
DISCUSSION Ocular adnexal lymphoproliferative disease
(OALD) consists of the spectrum of lymphoid
disease affecting the tissues surrounding the eye
including ocular adnexal lymphomas (OAL) and
lymphoid hyperplasia (LH) [4] The conjunctiva
is an important location for extranodal lympho-
ma development which comprises 25 of OAL
[5]
OAL can be grouped into two categories based
on their appearance of cells under the micro-
scope low-grade and high-grade [6] Extranodal
marginal zone lymphoma of mucosa-associated
lymphoid tissue (EMZLMALT) is the most
common subtype of OAL followed by follicular
lymphoma [7-9] Both of the above are
low-grade lymphomas
LH can be further divided by histopathology into
reactive lymphoid hyperplasia (RLH) and atypi-
cal lymphoid hyperplasia (ALH) RLH has to-
tally benign morphology and immunophenotype
whereas ALH has borderline lesions between
RLH and lymphoma [10] OAL and LH are
mostly seen in patients with age between 50-70
years old There are rare cases in pediatric group
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
114
[71011] In the C-Y Chengrsquos statistical report of
OAL in Taiwan only 8 patients were younger
than 15 years old among the 101 cases of ocular
lymphoma [2] According to an US study inci-
dence rates of OAL were analyzed in different
age groups the group of age over 50 had the
highest incidence rate of 574 per million per-
son-years while the 0-19 age group had the
lowest incidence rate of 009 per million per-
son-years [12] The incidence of LH was even
less than OAL [13]
Patients with OALD may be asymptomatic or
with symptoms of proptosis eyelid swelling a
palpable painless mass or conjunctival salmon
patch Diplopia visual loss pain or inflamma-
tion occurred less frequently implying more
aggressive features [714]
Orbital LH is not distinguishable from low-grade
lymphoma radiologically They both typically
present a round or lobulated mass that diffusely
moderately enhances with contrast and usually
shows homogenous hypointense or isointense to
muscle barely invasion to bone or nervous sys-
tem [10] Atypical appearances including inho-
mogeneous calcification or bony changes may
be seen in high-grade lymphoma case reports
such as ocular adnexal diffuse large B-cell lym-
phoma (DLBCL) which is one of the more ag-
gressive type of OAL [7] Whole body PET is
used for not only the evaluation of systemic
involvement but also the standard for staging
lymphoma Our patientrsquos image studies revealed
neither obvious local invasion nor systemic ma-
lignancy indicating high-grade lymphoma was
less likely Low-grade lymphoma and benign
reactive lymphoid hyperplasia were still under
consideration
Histomorphology analysis and immunohisto-
chemistry (IHC) are essential for diagnosis
Flow cytometry and polymerase chain reaction
(PCR) technique are also applied to help differ-
entiate from RLH and OAL [1016] Our case
had immunohistochemical profile of positivity
for CD20 predominantly positivity focally for
CD3 CD5 CD10 CD23 and negativity for cy-
clin-D1 BCL-6 staining was not performed in
our casersquos biopsy Thus according to the IHC
report RLH ALH and follicular lymphoma are
probable diagnosis of our patient
Radiation therapy is the standard treatment for
low-grade OAL that is classified as T1N0M0 or
T2N0M0 according to the AJCC criteria [15]
İncesoy-Ouml zdemir S et al reported a 10-year-old
boy diagnosed of MALT lymphoma who was
treated with local radiotherapy (36 Gy) and
there were no local or systemic recurrences dur-
ing his nearly four-year follow-up [17] Another
case report represented a 21-year-old man of
conjunctival follicular lymphoma treated with
surgical excision only showing no evidence of
recurrence after 8 months follow-up [18] Other
treatment options for pediatric and juvenile OAL
were performed in some case reports including
intravenous rituximab intralesional interfer-
on-α-2b topical interferon a6 systemic doxycy-
cline surgical excision and postoperative local
cryotherapy [15]
Treatment for young conjunctival RLH was less
discussed in the past In a case series article
three children (9 13 14 years old respectively)
of RLH received surgical resection without fur-
ther postoperative management and no signs of
recurrence were noted during follow-up [19]
Short-term topical and oral corticosteroids after
surgical excision were prescribed in two pediat-
ric RLH patients for their small residual mass
However poor response in both cases was nota-
ble [20]
Our patient declined to receive radiotherapy or
any further postoperative treatment mainly due
to his concerning of possible side effects (such
as dry eye and cataract)
CONCLUSION We present a rare case of caruncle mass in this
report OALD is one of the relatively uncommon
diagnosis among caruncular lesions OALD
includes benign RLH and malignant OAL
which are both mainly seen in elderly patients
even rarer in pediatric or juvenile group
The standard treatment for low-grade OAL and
RLH in young patents are still debatable How-
ever long-term follow-up is suggested for both
OAL and RLH patients Though RLH has a be-
nign and self-limited course risk of malignant
transformation is possible
REFERENCES 1 Levy J Ilsar M Deckel Y et al Lesions of
the caruncle a description of 42 cases and
a review of the literature Eye
200923(5)1004-1018
2 C-Y Cheng and W-M Hsu Incidence of
eye cancer in Taiwan an 18-year review
Eye 200418152-158
3 Chui-Lien Tsen Muh-Chiou Lin
Youn-Shen Bee et al Ocular adnexal
lymphoma Five case reports and a
literature review Taiwan Journal of
Ophthalmology 20155(2)99-102
4 Liesegang TJ Ocular adnexal
lymphoproliferative lesions Mayo Clin
Proc 199368(10)1003-1010
5 Kirkegaard MM Coupland SE Prause JU
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
115
et al Malignant lymphoma of the
conjunctiva Surv Ophthalmol
201560(5)444-458
6 Stacy RC Jakobiec FA Schoenfield L et
al Unifocal and multifocal reactive
lymphoid hyperplasia vs follicular
lymphoma of the ocular adnexa Am J
Ophthalmol 2010150(3)412-426
7 Sullivan TJ Ocular Adnexal
Lymphoproliferative Disease In Guthoff
RF Katowitz JA eds Oculoplastics and
Orbit Berlin Heidelberg Springer
20101-19
8 White Valerie A Understanding and
Classification of Ocular Lymphomas
Ocular Oncology and Pathology
20195379-386
9 Stefanovic A Lossos IS Extranodal
marginal zone lymphoma of the ocular
adnexa Blood 2009114(3)501-510
10 Andrew NH Coupland SE Pirbhai A et al
Lymphoid hyperplasia of the orbit and
ocular adnexa A clinical pathologic review
Surv Ophthalmol 201661(6)778-790
11 Ferry JA1 Fung CY Zukerberg L et al
Lymphoma of the ocular adnexa A study
of 353 cases Am J Surg Pathol
200731(2)170-184
12 WM Hassan MS Bakry HM Hassan et al
Incidence of orbital conjunctival and
lacrimal gland malignant tumors in USA
from Surveillance Epidemiology and End
Results 1973-2009 Int J Ophthalmol
20169(12)1808-1813
13 Ajay A Rao John H Naheedy James Y-Y
Chen et al A Clinical Update and
Radiologic Review of Pediatric Orbital
and Ocular Tumors Journal of Oncology
2013(9)975908
14 Sullivan TJ Whitehead K Williamson R
et al Lymphoproliferative disease of the
ocular adnexa a clinical and pathologic
study with statistical analysis of 69
patients Ophthal Plast Reconstr Surg
200521177-188
15 Tanenbaum RE Galor A Dubovy SR et al
Classification diagnosis and management
of conjunctival lymphoma Eye Vis (Lond)
2019622
16 Olga Klavdianou Georgios Kondylis
Vasileios Georgopoulos et al Bilateral
benign reactive lymphoid hyperplasia of
the conjunctiva a case treated with oral
doxycycline and review of the literature
Eye Vis (Lond) 2019626
17 İncesoy-Ouml zdemir S Yuumlksek N Bozkurt C
et al A rare type of cancer in children
extranodal marginal zone B-cell (MALT)
lymphoma of the ocular adnexa Turk J
Pediatr 201456(3)295-298
18 Lynn J Poole Perry Frederick A Jakobiec
Peter A D Rubin Conjunctival Pediatric
Follicular Lymphoma Arch Ophthalmol
2012130(7)941-943
19 Abdullah Al-Mujaini Upender Wali
Anuradha Ganesh1 et al Ocular Adnexal
Reactive Lymphoid Hyperplasia in
Children Middle East Afr J Ophthalmol
201219(4)406-409
20 McLeod SD Edward DP Benign
lymphoid hyperplasia of the conjunctiva in
children Arch Ophthalmol
1999117(6)832-835
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
116
FIGURES
Figure 1 Slit lamp image of a mass lesion at the patientrsquos left eye caruncle for one month
Figure 2 One month after the first excision a protruding mass recurred at the patientrsquos nasal canthus
of left eye It partially involved beyond the gray line of nasal part lower eyelid
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
117
Figure 3 Histomorphology analysis and immunohistochemistry study of the caruncular lesion Abun-
dant atypical lymphoid proliferation presented in low-power photomicrograph (A) and
high-power photomicrograph (B) under hematoxylin-eosin staining The lymphoid aggrega-
tion was composed predominantly of CD20-positive cells (C) and focal positive staining of
CD3 (D)
Figure 4 Non-contrast orbital computed tomography showed a lesion of soft tissue density at medial
canthus of left orbit without obvious nasolacrimal duct or bony invasion (A) Magnetic reso-
nance imaging with contrast showed strong enhancement at left medial canthus region (B)
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
118
Figure 5 The follow-up photo were taken at three months after the second excision showing no signs
of recurrence
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
119
Juvenile Caruncular Atypical Lymphoid Proliferation ndash A Rare Case Report
罕見病例報告mdash青少年之淚阜非典型淋巴增生
施驊瑋 1林友祺 1
中文摘要
淚阜病灶相當罕見大部分為良性病灶眼睛及附屬結構淋巴增生疾病為其
鑑別診斷之一非常少見於年輕人或兒童我們報告一位 16歲的健康男性因
左眼淚阜無痛性腫塊接受切除手術卻於術後一個月復發執行第二次切除手術
後門診追蹤十個月未再復發此案例表現了部分良性與部分惡性腫瘤的特徵
我們針對反應性淋巴增生眼睛及附屬結構淋巴癌兩個疾病做討論及文獻回顧
關鍵字淚阜病灶眼睛及附屬結構淋巴增生疾病眼睛及附屬結構淋巴癌反
應性淋巴增生非典型淋巴增生
1 新光吳火獅紀念醫院眼科
通訊作者林友祺 電子信箱 yuchi067gmailcom
Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh 120
Submitted March 26 2020
Final version accepted April 16
2020
Case Report
Hyperacute intramembranous hemor-
rhage after burr hole craniostomy for
chronic subdural hematoma
Cite as Meng-Chi Lin Jui-Ming
Sun Yu-Hao Chen Cheng-Ta
Hsieh
Hyperacute intramembranous
hemorrhage after burr hole crani-
ostomy for chronic subdural he-
matoma Fu-Jen Journal of Medi-
cine 3(4) 120-125 2020
DOI
103966181020932020091803004
Meng-Chi Lin1 Jui-Ming Sun23 Yu-Hao Chen24 Cheng-Ta
Hsieh567
1Department of Surgery Zuoying Branch Kaohsiung Armed Forces
General Hospital Kaohsiung 813 Taiwan 2Section of Neurosurgery Department of Surgery Chia-Yi Christian
Hospital Chia-Yi City 600 Taiwan 3Department of Biotechnology Asia University Taichung City 41354
Taiwan 4Chung-Jen Junior College of Nursing Health Sciences and Manage-
ment Chia-Yi Country 62241 Taiwan 5Division of Neurosurgery Department of Surgery Sijhih Cathay Gen-
eral Hospital New Taipei City 22174 Taiwan 6Department of Medicine School of Medicine Fu Jen Catholic Univer-
sity New Taipei City 24205 Taiwan 7Department of Neurological Surgery Tri-Service General Hospital
National Defense Medical Center Taipei 114 Taiwan
Corresponding author E-mail address
nogormail2000comtw (Cheng-Ta Hsieh)
ABSTRACT
Burr hole craniostomy with closed-system drainage is an effective and common neurosurgical procedure to manage chronic subdural hematoma Postoperative hem-orrhage a well-known but infrequent complication may result in increased neurolog-ical deficits However hyperacute intramembranous hemorrhage within the inner and outer membrane of hematoma after burr hole craniostomy with irrigation and closed-system drainage has not been described previously Herein we report a case of postoperative spontaneous hyperacute intramembranous hemorrhage after burr hole craniostomy with closed-system drainage to manage a chronic subdural hematoma we subsequently discuss the possible pathophysiological mechanisms and review the relevant literature
Keywords Chronic subdural hematoma acute subdural hematoma bleeding burr hole craniostomy
drainage
Fu-J
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Vol 3 No 4 2
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Vol 3 No 4 2
Acute intram
Yu-Hao Chen
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Vol 3 No 4 2
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Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh
125
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
慢性硬腦膜下出血進行鑽顱引流手術造成超急性夾膜內出
血
林孟楫 1孫瑞明 23陳昱豪 24謝政達 567
中文摘要
鑽顱併封閉系統引流手術是治療慢性硬腦膜下出血患者一種有效且常見的
神經外科手術方式術後出血可能導致神經功能缺損惡化是眾所周知但不常見
的併發症之一然而至今仍未有鑽孔併封閉系統引流造成原本慢性硬腦膜血
塊內膜和外膜間急性夾膜間出血案例在這裡我們報告一例慢性硬腦膜下出
血病患者接受鑽顱併封閉系統引流手術治療造成術後急性夾膜間出血我們在
本文中討論可能的致病機制並回顧相關文獻
關鍵字慢性硬腦膜下出血急性硬腦膜下出血出血鑽顱術引流
1國軍高雄總醫院左營分院 外科部
2崇仁醫護管理專科學校
3亞洲大學 生物科技學系
4戴德森醫療財團法人嘉義基督教醫院 外科部 神經外科
5汐止國泰綜合醫院 神經外科
6輔仁大學 醫學系
7 國防醫學院 三軍總醫院 神經外科
通訊作者謝政達 電子信箱 nogormail2000comtw
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
126
Submitted January 21 2020
Final version accepted July 08
2020
Case Report
Hamartoma of the breast A case report
Cite as Hsuan-An Chen
Cheng-Yu Lo Shih-Hung Huang
Chin-Lung Lin
Hamartoma of the breast A case
report Fu-Jen Journal of Medicine
3(5) 126-130 2020
DOI
103966181020932020091803005
Hsuan-An Chen1 Cheng-Yu Lo
3 Shih-Hung Huang
3 Chin-Lung
Lin2
1Department of Surgery Cathay General Hospital Taipei Taiwan
2Department of General Surgery Cathay General Hospital Taipei Tai-
wan
3Department of Pathology Cathay General Hospital Taipei Taiwan
Corresponding author E-mail address
lungyungmailcom (Chin-Lung Lin)
ABSTRACT
Breast hamartoma is an uncommon benign tumor rarely associated with malignancy An
excision and histological examination is necessary for the differential diagnosis We report
a case of a 49-year-old female patient presenting with a lump in the right breast Ultrasound
examination which demonstrated a 4411 cm hypoechoic lesion with lipoma Partial mas-
tectomy was arranged and the diagnosis of a hamartoma was confirmed by the histological
examination
Keywords Breast tumor Hamartoma Ultrasound
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
127
INTRODUCTION The hamartoma is a benign tumor-like lesion
that can affect various organs of the body in-
cluding lungs kidneys skin and more rarely the
breast In 1981 the hamartomas were recognized
in the WHO classification[1] They are defined
as well-demarcated mass of mammary ducts and
lobules containing varying amounts of fibrous
and adipose tissue and producing a distinctive
mammographic image
CASE REPORT A 49 year-old female had past history of left
breast mastitis with abscess status post partial
mastectomy This time she presented to our out
patient clinic for breast examination Physical
examination revealed a painless palpable mova-
ble and painless lump at upper outer quadrant of
right breast The risk of breast cancer was not
noted and the patient did not have any family
history of breast cancer The patient also denied
any trauma history before Ultrasound examina-
tion was arranged which demonstrated a 4411
cm hypoechoic lesion with lipoma at 3 oclock 2
cm from nipple of right breast and multiple hy-
poechoic nodules of various size in both breasts
and there was no suspicious axillary lymph
nodes noted (Figure1) Surgical treatment was
arranged partial mastectomy of right breast
harmartoma was successfully performed A 32 x
31 x 21 cm tumor was completely excised
Grossly examination showed a gray to yellow
and firm to fatty The diagnosis of a hamartoma
was confirmed by the histological examination
Microscopically sections of the breast lesion
show mammary hamartoma composed of ducts
lobules with interlobular fibrous tissue and adi-
pose tissue Fibrocystic change apocrine meta-
plastic ducts and scattered foci of adenosis are
noted The overall lobulocentric architecture and
the 2-cell pattern of the epithelium are preserved
columnar cell change and focal microcalcifica-
tion are present (Figure2) Based on submitted
biopsy specimen in-situ or invasive tumor cells
are not identified
DISCUSSION Hamartoma of the breast is a benign tumor like
nodule it was also known as fibroadenolipoma
lipofibroadenoma or adenolipoma based on its
predominant components It was composed of
varying amounts of glandular adipose and fi-
brous tissue[2] Hamartomas were first described
in 1971 by Arrigoni et al in a study of 10 patients
which breast tumors clinically and grossly re-
sembled fibroadenomas[3]
A higher predominance of tumors exists in fe-
males compared with males Hamartomas are
slowly-growing lesions with the diameter rang-
ing from 2 cm to 5 cm sometimes hamartomas
can reach giant diameter [4]
The clinical diagnosis of hamartoma is based on
the findings from mammography sonography
and histology examinations The hamartomas are
usually incidentally diagnosed by the women
older than 40 year-old starting mammography
screening
On physicial examination harmatomas are usu-
ally occult painless they may be as large mo-
bile soft to firm masses[5] Ultrasound showed
well capsulated mass with echogenic rim and
internal heterogeneity Mammography exam
showed well-circumscribed round to oval
masses containing fat and soft tissue densities
with a thin radiopaque pseudocapsule The
pseudocapsule results from displacement of
breast parenchyma by the tumor [56] In Pa-
thology finding microglandular adenosis is pre-
sent in fibroadipose stroma surrounded by a thin
fibrous capsule It composed of a combination of
epithelial and stromal elements usually with
normal ducts or lobules although variations of
normal tissue may also be seen Fibroadenoli-
poma myoid hamartoma and chondrolipoma are
histological variations of hamartomas depend-
ing on the proportion of normal breast tissue
elements[7]
Malignancy associated with hamartomas are
very rare[8] However it has been reported
hamartomas develop into carcinoma Malignant
transformation can occur as a result of cellular
atypia in the epithelial component of the mass[9]
Surgical removal is the curative method for
breast hamartomas[10] Diagnostic material such
as mammography ultrasonography or core nee-
dle biopsy may not give the definitive diagnosis
Therefore surgical excision and histological
examination is necessary for differential diagno-
sis[111213]
Although it is rare hamartoma can be seen along
with malignancy as it is formed from similar
components of breast tissue Therefore careful
diagnosis and appropriate management including
surgery are required
REFERENCES 1 World Health Organization (1981)
Histological typing of breast tumors In
International histological classification of
tumors 1981 2nd ed
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
128
2 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11435ndash449
2006
3 ArrigoniMG DockertyMB JuddES
The identificationand treatment of
mammary hamartoma Surg Gynecol
Obstet1971 133 577-82
4 Sanal HT Ersoz N Altinel O Unal E Can
C Giant hamartoma of the breast Breast J
2006 12 84-85
5 Feder JM de Paredes ES Hogge JP
Wilken JJ Unusual breast lesions
radiologic-pathologic correlation
Radiographics 1999 19S11ndashS26
6 Murat A Ozdemir H Yildirim H Poyraz
AK Ozercan R Hamartoma of the breast
Australas Radiol 200751 Spec NoB37ndash
9
7 Fisher CJ Hanby AM Robinson L Millis
RR Mammary hamartoma-a review of 35
cases Histopathology 1992 20 99-106
8 Choi N Ko ES Invasive ductal carcinoma
in a mammary hamartoma case report and
review of the literature Korean J Radiol
2010 Nov-Dec11(6)687-91
9 Lee EH Wylie EJ Bourke AG Bastiaan
De Boer W Invasive ductal carcinoma
arising in a breast hamartoma two case
reports and a review of the literature Clin
Radiol 2003 58 80-3
10 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11 435 ‑449
2006
11 Coyne J Hobbs FM Boggis C Harland R
Lobular carcinoma in a mammary
hamartoma J Clin Pathol 199245936ndash
937
12 G M K Tse B K B Law T K F Ma A B W
Chan Hamartoma of the breast a
clinicopathological review J Clin Pathol
200255951ndash954
13 RAAmir SSheikh BreasthamartomaA
report of 14cases of an under-recognized
and under-reported entity International
Journal of Surgery Case Reports
22(2016)1ndash4
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
129
FIGURES
Figure 1 Ultrasound shows a 4411 cm hypoechoic lesion with lipoma at 3 oclock 2 cm from nipple
of right breast
Figure 2 Photomicrograph shows mammary hamartoma composed of ducts lobules with interlobular
fibrous tissue and adipose tissue
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
130
Hamartoma of the breast A case report
乳房錯構瘤罕見個案報告
陳宣安 1羅承裕 3黃世鴻 3林錦龍 2
中文摘要
乳房錯構瘤是一種罕見之乳房良性腫瘤切除手術及病理化驗來做鑑別診斷
我們報告一位 49歲女性以可觸摸到無痛性右側乳房腫塊為臨床表徵超音波
看到一個邊緣清楚低迴音的腫塊病患接受手術切除病灶病理診斷證實為乳
房錯構瘤
關鍵字乳房腫瘤錯構瘤超音波攝影
1國泰綜合醫院外科部
2國泰綜合醫院一般外科
3國泰綜合醫院病理科
通訊作者林錦龍 電子信箱 lungyungmailcom
Fu-Jen Journal of Medicine
Mission and Goals
The Fu-Jen Journal of Medicine (FJJM) is a peer-reviewed journal which
aims to enhance research quality of staffs in the College of Medicine Fu Jen
Catholic University The journal publishes original investigations across a
wide range of medical disciplines including original research articles in basic
and clinical sciences case reports review articles brief reports and letter
to the editor FJJM is now issued by the Center of Medical Education in the
College of Medicine Fu Jen Catholic University To promote journal quality
the manuscript submitted to FJJM after August first 2015 has to be prepared
in English to meet the international standards
Issue Date
Publication Date
Institution
December 01 2003
September 30 2020
College of Medicine Fu Jen Catholic University
Honorable publisher Han-Sun Chiang
Publisher Ping-Keung Yip
Editor-in-chief Ming-Chieh Ma
Associate Editors Yu-Wen Lin
Editors
Telephone (02) 2905-3477
Address Center for Medical Education College of Medicine Fu Jen
Catholic University
No 510 Zhongzheng Rd Xinzhuang Dist New Taipei City
24205 Taiwan
Su-Jane Wang Chi-Chung Wang Chih-Ming Ho
Yih-Jing Lee Chih-Shung Wong Tze-Wah Kao
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Chia-Chen Lu Zai-Ting Yeh
Dee Pei Chih-Kuang Liu
Hen-Hui Lien Chien-Hsiou Liu
Chun-Hou Liao Yi-Ju Tsai Sheng-Wen Teng
Chia-Ting Su
- 9月封面
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-
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 106
Figure 2 Preconditions (Latent Failures or Conditions) (N=40)
14 (250)
24 (500)
48 (500)
11 (1000)
18 (125)
840 (200)
0 5 10 15 20 25 30 35 40
Seat and Restraint System Problems
Instrumentation amp Warning System Issues
Noise Interference
Environment
Physical Environment
Technological Environment
27 (286)
27 (286)
27 (286)
37 (129)
47 (511)
47 (571)
77 (1000)
24 (500)
44 (1000)
47 (571)
12 (500)
22 (1000)
27 (286)
740 (175)
0 5 10 15 20 25 30 35 40
Technical or Procedural Knowledge Not Retained After Training
InterferenceInterruption
Task OverUnder Saturation
Distraction
Negative Habit Transfer
Not Paying Attention
Complacency
Overconfidence
Physical IllnessInjury
Fatigue
Physical and Mental State
Physical Problem
State of Mind
Mental Awareness
211 (182)
311 (273)
311 (273)
411 (364)
811 (7227)
911 (818)
1140 (275)
0 5 10 15 20 25 30 35 40
Inadequate Task Delegation
TaskMission PlanningBriefingDebriefing Inadequate
Failure of CrewTeam Leadership
StandardProper Terminology Not Used
Critical Information Not Communicated
Failed to Effectively Communicate
Teamwork
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 107
Figure 3 Supervision (Direct Supervisory Chain of Command) (N=40)
Figure 4 Organization Influence (Upper-Level Management Command Level) (N=40)
114 (71)
114 (71)
214 (143)
314 (214)
1314 (929)
1440 (350)
511 (455)
511 (455)
711 (636)
1140 (275)
47 (571)
67 (857)
740 (175)
0 5 10 15 20 25 30 35 40
Selected Individual with Lack of Proficiency
Improper Role‐modeling
Failed to Provide Proper Training
Failed to IdentifyCorrect Risky or Unsafe Practices
SupervisoryCommand Oversight Inadequate
Performed Inadequate Risk Assessment ‐Formal
Selected Individual with Lack of Current or Limited Experience
Authorized Unnecessary Hazard
Allowing Unwritten Policies to Become Standard
Failure to Enforce Existing Rules
Supervisory Violations
Planned Inappropriate Operations
Inadequate Supervision
12 (500)
12 (500)
240 (50)
110 (100)
510 (500)
1040 (250)
11 (1000)
140 (25)
18 (125)
18 (125)
38 (35)
48 (500)
840 (200)
0 5 10 15 20 25 30 35 40
Organizational Over-confidence or Under-confidence in Equipment
Organizational Culture (attitude actions) Allows for Unsafe TaskMission
Purchasing or Providing Poorly Designed or Unsuitable Equipment
Organizational ProgramPolicy Risks not Adequately Assessed
Failure to Provide Adequate Manning Staffing Resources
Failure to remove inadequate worn-out equipment in timely manner
Inadequate infrastructure
Command and control resources are deficient
Failure to provide adequate operational information resources
Resource Problems
Personnel Selection amp Staffing
Policy and Process Issues
ClimateCulture Influences
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 108
Supplement Table 1- HFACS Content of Human Factor Analysis Classifi-
cation System [9] Tier main level sub-item nano code
Tier 1 Unsafe Acts
Perfor-
mance-Based
Errors
Unintended operation of equipment
Checklist not followed correctly
Procedure not followed correctly
Over-controlledunder-controlled aircraftvehiclesystem
Breakdown in visual scan
Rushed or delayed a necessary action
Judgment amp De-
cision-Making
Errors
Inadequate real‐time risk assessment
Failure to prioritize tasks adequately
Ignored a cautionwarning
Wrong choice of action during an operation
Violations
Performs work-around violation
Commits widespreadroutine violation
Extreme violation-lack of discipline
Tier 2 Preconditions
Environment
Physical environment
Environmental conditions affecting vision
Vibration effects vision or balance
Heatcold stress impairs performance
External force of object impeded an individualrsquos
movement
Lights of other vehiclevesselaircraft affected vision
Noise interference
Technological environment
Seat and restraint system problems
Instrumentation amp warning system issues
Visibility restrictions (not weather related)
Controls and switches are inadequate
Automated system creates unsafe situation
Workspace incompatible with operation
Personal equipment interference
Communication equipment inadequate
Physical and
Mental State
Physical problem
Substance effects (alcohol supplements medications
drugs)
Loss of consciousness (sudden or prolonged onset)
Physical illnessinjury
Fatigue
Inadequate adaptation to darkness
Dehydration
Body sizemovement limitations
Physical strength amp coordination (inappropriate for
task demands)
Nutritiondiet
State of mind
Psychological problem
Life stressors
Emotional state
Personality style
Overconfidence
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 109
Pressing
Complacency
Motivation
Motivational exhaustion (burnout)
Sensory misperception
Motion illusion-kinesthetic
Turning illusionbalance-vestibular
Visual illusion
Misperception of changing environment
Misinterpreted misread instrument
Misinterpretation of auditorysound cues
Spatial disorientation
Temporaltime distortion
Mental awareness
Not paying attention
Fixation
Task overunder saturation
Confusion
Negative habit transfer
Distraction
Geographically lost
Interferenceinterruption
Technical or procedural knowledge not retained after
training
Inaccurate expectation
Teamwork
Failure of crewteam leadership
Inadequate task delegation
Rankposition intimidation
Lack of assertiveness
Critical information not communicated
Standardproper terminology not used
Failed to effectively communicate
Taskmission planningbriefingdebriefing inadequate
Tier 3 Supervision
Supervisory Vio-
lations
Failure to enforce existing rules
Allowing unwritten policies to become standard
Directed individual to violate existing regulations
Authorized unqualified individuals for task
Planned Inappro-
priate Operations
Directed task beyond personnel capabilities
Inappropriate team composition
Selected individual with lack of current or limited experience
Performed inadequate risk assessment ‐formal
Authorized unnecessary hazard
Inadequate Su-
pervision
Supervisorycommand oversight inadequate
Improper role‐modeling
Failed to provide proper training
Failed to provide appropriate policyguidance
Personality conflict with supervisor
Lack of supervisory responses to critical information
Failed to identifycorrect risky or unsafe practices
Selected individual with lack of proficiency
Tier 4 Organizational
Influences
Resource Prob-
lems
Command and control resources are deficient
Inadequate infrastructure
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 110
Failure to remove inadequate worn-out equipment in timely
manner
Failure to provide adequate operational information resources
Fail to provide adequate funding
Personnel Selec-
tion amp Staffing
Personnel recruiting amp selection policies are inadequate
Failure to provide adequate manning staffing resources
Policy amp Process
Issues
Pace of ops-tempoworkload
Organizational programpolicy risks not adequately assessed
Provided inadequate procedural guidance or publications
Organizational (formal) training is inadequate or unavailable
Flawed doctrinephilosophy
Inadequate program management
Purchasing or providing poorly designed or unsuitable equip-
ment
ClimateCulture
Influences
Organizational culture (attitude actions) allows for unsafe
taskmission
Organizational over-confidence or under-confidence in equip-
ment
Unit missionaircraftvehicleequipment change or unit deacti-
vation
Organizational structure is unclear or inadequate
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 111
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
以 HFACS重新檢視根本原因分析案例挖掘造成醫療不良
事件之人為因素
鄭伃洵 1洪聖惠 12柯彤文 3王拔群 14
中文摘要
背景醫療不良事件(AMEs)的管理是促進病人安全的基石根本原因分析
(RCA)是探討重大病人安全不良事件問題但是由於無法解釋更廣泛的因素而受
到限制本研究使用人為因素分類與分析工具(HFACS)回溯審視醫療不良事件
以了解影響醫療不良事件的人為因素及各層面中錯誤原因之分佈或系統性問題
方法本研究回溯 2012-2016年間有做過根本原因分析之醫療不良事件以連續
性取樣方式(continuous sampling)收集 40例醫療不良事件以人為因素分類與分
析工具(HFACS)去系統性的挖掘每件案例發生錯誤之原因結果在行為層面中
分析結果主要為基礎技能錯誤(95)判斷和決策錯誤(875)其中在基礎技能
錯誤當中以未依程序作業執行(816)及未如預期設備操作(50)佔多數判斷和
決策錯誤中以現場風險評估不確實(686)及採取錯的步驟行為(686)佔多數
而在先決條件層面中以團隊合作(275)為主要因素包含溝通不良(818)及重
要訊息未以正確的方式即時傳達(727)佔多數在監督層面當中以監督不周
(929)或監督不妥當(929)為主要因素在組織政策和流程方面(50)以組織
系統的政策風險未充分評估(35)為主要因素結論本研究進一步了解醫療不
良事件在過去使用根本原因分析未探討到的人為因素反映出潛在的監督組織
行為或系統性的問題促進病人安全預防錯誤再發生
關鍵字病人安全醫療不良事件根本原因分析人為因素
1國泰醫療財團法人國泰綜合醫院 品質管理部
2國立臺灣大學健康政策與管理研究所
3振興醫療財團法人振興醫院 醫療品質管理中心
4輔仁大學醫學院
通訊作者王拔群 電子信箱 drtonyseednettw
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin 112
Submitted January 20 2020
Final version accepted April13
2020
Case Report
Juvenile Caruncular Atypical Lymphoid
Proliferation ndash A Rare Case Report
Cite as Hua-Wei Shih Yu-Chi Lin
Juvenile Caruncular Atypical
Lymphoid Proliferation ndash A Rare
Case Report Fu-Jen Journal of
Medicine 3(3) 112-119 2020
DOI
103966181020932020091803003
Hua-Wei Shih1 Yu-Chi Lin
1
1Department of Ophthalmology Shin Kong Wu Ho-Su Memorial Hos-
pital Taipei City Taiwan
Corresponding author E-mail address
yuchi067gmailcom (Yu-Chi Lin)
ABSTRACT
Lesions of the caruncle are very rare Most caruncular lesions are benign though there were still few reported malignant lesions Ocular adnexal lymphoproliferative disease (OALD) one of the differential diagnosis of caruncular lesion is seldom seen in young pa-tient In this article we report a 16-year-old boy with recurrent caruncular atypical lym-phoid proliferation We discuss the epidemiology clinical features images histomorpholo-gy and treatment between ocular adnexal lymphomas (OAL) and reactive lymphoid hyper-plasia (RLH)
Keywords caruncular lesion ocular adnexal lymphoproliferative disease ocular adnexal lymphoma
reactive lymphoid hyperplasia atypical lymphoid proliferation
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
113
INTRODUCTION Lesions of the caruncle are very rare Differen-
tial diagnosis includes nevus myeloproliferative
disorders tumors inflammation infection cysts
vascular lesions and fibrous Biopsy is essential
for diagnosis Levy J et al reported ocular ad-
nexal lymphoproliferative disease (OALD) was
relatively uncommon diagnosis among caruncu-
lar lesions [1]
OALD was seldom described in Asian popula-
tion especially for young age C-Y Cheng re-
ported age-standardized incidence of ocular
adnexal lymphomas (OAL) in Taiwan from 1979
to 1996 was below 07 per million per year and
mean age was 531 years old [2] In 2015 five
Taiwanese cases of OAL whose age ranging
from 45 to 64 were presented [3] However
there were few cases of conjunctival OAL or
RLH in Chinese pediatric patient
Here we present a case of 16-year-old boy with a
caruncular mass at his left eye with recurrence
one month after excision We describe his clini-
cal symptoms photographs pathological results
management and follow-up clinical course in
this report
CASE REPORT A 16-year-old healthy boy presented a mass
lesion at his left eye caruncle accompanied with
the symptom of tearing for one month (Figure 1)
He had no ocular pain no itchiness no blurred
vision no night sweating no fever and no body
weight loss The patient denied systemic diseas-
es and histories of surgery His bilateral best
corrected visual acuity (BCVA) were 66 and
intraocular pressure (IOP) were both within
normal range There were no remarkable find-
ings for his cornea lens fundus and physical
examination Excision was performed and the
mass was soft with fluid inside therefore con-
junctival pyogenic cyst was our initial diagnosis
However one month after the excision a pro-
truding mass recurred at the patientrsquos nasal can-
thus of left eye (Figure 2) There were some
differences compared to previous condition At
the first time the soft mass was contained in a
well-defined cyst wall which more favored py-
ogenic granulation However after short period
of recurrence solid consistency and unclear
margin were found which favored malignancy
Besides the mass partially involved beyond the
gray line of nasal part lower eyelid whereas last
time the cyst mainly extended from conjunctiva
of caruncle The second excisional biopsy was
performed Pathologic examination demonstrat-
ed abundant atypical lymphoid proliferation
(Figure 3A 3B) Immunohistochemical studies
showed that the lymphoid aggregation was
composed predominantly of CD20-positive cells
(Figure 3C) focal positive staining of CD3
(Figure 3D) CD5 CD23 CD10 and negative
staining of cyclin-D1 Unfortunately the cellular
morphology was difficult to be evaluated due to
marked crushing artifact Thus malignant lym-
phoma cannot be excluded totally
Orbital computed tomography (CT) showed a
lesion of soft tissue density at medial canthus of
left orbit without obvious nasolacrimal duct or
bony invasion (Figure 4A) Magnetic resonance
imaging (MRI) with contrast showed strong
enhancement at left medial canthus region (Fig-
ure 4B) There was no remarkable finding in the
systemic workup including complete blood
count and differential count biochemical pro-
files and 18F-fluoro-2-deoxyglucose positron
emission tomographycomputed tomography
(18F-FDG PETCT) indicating no evidence of
systemic involvement
After the second excision we preferred con-
servative management for him due to the uncer-
tainty of malignancy and to avoid side effects
from aggressive treatment No sign of recurrence
was noted after 10 months of observation The
follow-up photo was taken at three months after
the second operation (Figure 5)
DISCUSSION Ocular adnexal lymphoproliferative disease
(OALD) consists of the spectrum of lymphoid
disease affecting the tissues surrounding the eye
including ocular adnexal lymphomas (OAL) and
lymphoid hyperplasia (LH) [4] The conjunctiva
is an important location for extranodal lympho-
ma development which comprises 25 of OAL
[5]
OAL can be grouped into two categories based
on their appearance of cells under the micro-
scope low-grade and high-grade [6] Extranodal
marginal zone lymphoma of mucosa-associated
lymphoid tissue (EMZLMALT) is the most
common subtype of OAL followed by follicular
lymphoma [7-9] Both of the above are
low-grade lymphomas
LH can be further divided by histopathology into
reactive lymphoid hyperplasia (RLH) and atypi-
cal lymphoid hyperplasia (ALH) RLH has to-
tally benign morphology and immunophenotype
whereas ALH has borderline lesions between
RLH and lymphoma [10] OAL and LH are
mostly seen in patients with age between 50-70
years old There are rare cases in pediatric group
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
114
[71011] In the C-Y Chengrsquos statistical report of
OAL in Taiwan only 8 patients were younger
than 15 years old among the 101 cases of ocular
lymphoma [2] According to an US study inci-
dence rates of OAL were analyzed in different
age groups the group of age over 50 had the
highest incidence rate of 574 per million per-
son-years while the 0-19 age group had the
lowest incidence rate of 009 per million per-
son-years [12] The incidence of LH was even
less than OAL [13]
Patients with OALD may be asymptomatic or
with symptoms of proptosis eyelid swelling a
palpable painless mass or conjunctival salmon
patch Diplopia visual loss pain or inflamma-
tion occurred less frequently implying more
aggressive features [714]
Orbital LH is not distinguishable from low-grade
lymphoma radiologically They both typically
present a round or lobulated mass that diffusely
moderately enhances with contrast and usually
shows homogenous hypointense or isointense to
muscle barely invasion to bone or nervous sys-
tem [10] Atypical appearances including inho-
mogeneous calcification or bony changes may
be seen in high-grade lymphoma case reports
such as ocular adnexal diffuse large B-cell lym-
phoma (DLBCL) which is one of the more ag-
gressive type of OAL [7] Whole body PET is
used for not only the evaluation of systemic
involvement but also the standard for staging
lymphoma Our patientrsquos image studies revealed
neither obvious local invasion nor systemic ma-
lignancy indicating high-grade lymphoma was
less likely Low-grade lymphoma and benign
reactive lymphoid hyperplasia were still under
consideration
Histomorphology analysis and immunohisto-
chemistry (IHC) are essential for diagnosis
Flow cytometry and polymerase chain reaction
(PCR) technique are also applied to help differ-
entiate from RLH and OAL [1016] Our case
had immunohistochemical profile of positivity
for CD20 predominantly positivity focally for
CD3 CD5 CD10 CD23 and negativity for cy-
clin-D1 BCL-6 staining was not performed in
our casersquos biopsy Thus according to the IHC
report RLH ALH and follicular lymphoma are
probable diagnosis of our patient
Radiation therapy is the standard treatment for
low-grade OAL that is classified as T1N0M0 or
T2N0M0 according to the AJCC criteria [15]
İncesoy-Ouml zdemir S et al reported a 10-year-old
boy diagnosed of MALT lymphoma who was
treated with local radiotherapy (36 Gy) and
there were no local or systemic recurrences dur-
ing his nearly four-year follow-up [17] Another
case report represented a 21-year-old man of
conjunctival follicular lymphoma treated with
surgical excision only showing no evidence of
recurrence after 8 months follow-up [18] Other
treatment options for pediatric and juvenile OAL
were performed in some case reports including
intravenous rituximab intralesional interfer-
on-α-2b topical interferon a6 systemic doxycy-
cline surgical excision and postoperative local
cryotherapy [15]
Treatment for young conjunctival RLH was less
discussed in the past In a case series article
three children (9 13 14 years old respectively)
of RLH received surgical resection without fur-
ther postoperative management and no signs of
recurrence were noted during follow-up [19]
Short-term topical and oral corticosteroids after
surgical excision were prescribed in two pediat-
ric RLH patients for their small residual mass
However poor response in both cases was nota-
ble [20]
Our patient declined to receive radiotherapy or
any further postoperative treatment mainly due
to his concerning of possible side effects (such
as dry eye and cataract)
CONCLUSION We present a rare case of caruncle mass in this
report OALD is one of the relatively uncommon
diagnosis among caruncular lesions OALD
includes benign RLH and malignant OAL
which are both mainly seen in elderly patients
even rarer in pediatric or juvenile group
The standard treatment for low-grade OAL and
RLH in young patents are still debatable How-
ever long-term follow-up is suggested for both
OAL and RLH patients Though RLH has a be-
nign and self-limited course risk of malignant
transformation is possible
REFERENCES 1 Levy J Ilsar M Deckel Y et al Lesions of
the caruncle a description of 42 cases and
a review of the literature Eye
200923(5)1004-1018
2 C-Y Cheng and W-M Hsu Incidence of
eye cancer in Taiwan an 18-year review
Eye 200418152-158
3 Chui-Lien Tsen Muh-Chiou Lin
Youn-Shen Bee et al Ocular adnexal
lymphoma Five case reports and a
literature review Taiwan Journal of
Ophthalmology 20155(2)99-102
4 Liesegang TJ Ocular adnexal
lymphoproliferative lesions Mayo Clin
Proc 199368(10)1003-1010
5 Kirkegaard MM Coupland SE Prause JU
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
115
et al Malignant lymphoma of the
conjunctiva Surv Ophthalmol
201560(5)444-458
6 Stacy RC Jakobiec FA Schoenfield L et
al Unifocal and multifocal reactive
lymphoid hyperplasia vs follicular
lymphoma of the ocular adnexa Am J
Ophthalmol 2010150(3)412-426
7 Sullivan TJ Ocular Adnexal
Lymphoproliferative Disease In Guthoff
RF Katowitz JA eds Oculoplastics and
Orbit Berlin Heidelberg Springer
20101-19
8 White Valerie A Understanding and
Classification of Ocular Lymphomas
Ocular Oncology and Pathology
20195379-386
9 Stefanovic A Lossos IS Extranodal
marginal zone lymphoma of the ocular
adnexa Blood 2009114(3)501-510
10 Andrew NH Coupland SE Pirbhai A et al
Lymphoid hyperplasia of the orbit and
ocular adnexa A clinical pathologic review
Surv Ophthalmol 201661(6)778-790
11 Ferry JA1 Fung CY Zukerberg L et al
Lymphoma of the ocular adnexa A study
of 353 cases Am J Surg Pathol
200731(2)170-184
12 WM Hassan MS Bakry HM Hassan et al
Incidence of orbital conjunctival and
lacrimal gland malignant tumors in USA
from Surveillance Epidemiology and End
Results 1973-2009 Int J Ophthalmol
20169(12)1808-1813
13 Ajay A Rao John H Naheedy James Y-Y
Chen et al A Clinical Update and
Radiologic Review of Pediatric Orbital
and Ocular Tumors Journal of Oncology
2013(9)975908
14 Sullivan TJ Whitehead K Williamson R
et al Lymphoproliferative disease of the
ocular adnexa a clinical and pathologic
study with statistical analysis of 69
patients Ophthal Plast Reconstr Surg
200521177-188
15 Tanenbaum RE Galor A Dubovy SR et al
Classification diagnosis and management
of conjunctival lymphoma Eye Vis (Lond)
2019622
16 Olga Klavdianou Georgios Kondylis
Vasileios Georgopoulos et al Bilateral
benign reactive lymphoid hyperplasia of
the conjunctiva a case treated with oral
doxycycline and review of the literature
Eye Vis (Lond) 2019626
17 İncesoy-Ouml zdemir S Yuumlksek N Bozkurt C
et al A rare type of cancer in children
extranodal marginal zone B-cell (MALT)
lymphoma of the ocular adnexa Turk J
Pediatr 201456(3)295-298
18 Lynn J Poole Perry Frederick A Jakobiec
Peter A D Rubin Conjunctival Pediatric
Follicular Lymphoma Arch Ophthalmol
2012130(7)941-943
19 Abdullah Al-Mujaini Upender Wali
Anuradha Ganesh1 et al Ocular Adnexal
Reactive Lymphoid Hyperplasia in
Children Middle East Afr J Ophthalmol
201219(4)406-409
20 McLeod SD Edward DP Benign
lymphoid hyperplasia of the conjunctiva in
children Arch Ophthalmol
1999117(6)832-835
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
116
FIGURES
Figure 1 Slit lamp image of a mass lesion at the patientrsquos left eye caruncle for one month
Figure 2 One month after the first excision a protruding mass recurred at the patientrsquos nasal canthus
of left eye It partially involved beyond the gray line of nasal part lower eyelid
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
117
Figure 3 Histomorphology analysis and immunohistochemistry study of the caruncular lesion Abun-
dant atypical lymphoid proliferation presented in low-power photomicrograph (A) and
high-power photomicrograph (B) under hematoxylin-eosin staining The lymphoid aggrega-
tion was composed predominantly of CD20-positive cells (C) and focal positive staining of
CD3 (D)
Figure 4 Non-contrast orbital computed tomography showed a lesion of soft tissue density at medial
canthus of left orbit without obvious nasolacrimal duct or bony invasion (A) Magnetic reso-
nance imaging with contrast showed strong enhancement at left medial canthus region (B)
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
118
Figure 5 The follow-up photo were taken at three months after the second excision showing no signs
of recurrence
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
119
Juvenile Caruncular Atypical Lymphoid Proliferation ndash A Rare Case Report
罕見病例報告mdash青少年之淚阜非典型淋巴增生
施驊瑋 1林友祺 1
中文摘要
淚阜病灶相當罕見大部分為良性病灶眼睛及附屬結構淋巴增生疾病為其
鑑別診斷之一非常少見於年輕人或兒童我們報告一位 16歲的健康男性因
左眼淚阜無痛性腫塊接受切除手術卻於術後一個月復發執行第二次切除手術
後門診追蹤十個月未再復發此案例表現了部分良性與部分惡性腫瘤的特徵
我們針對反應性淋巴增生眼睛及附屬結構淋巴癌兩個疾病做討論及文獻回顧
關鍵字淚阜病灶眼睛及附屬結構淋巴增生疾病眼睛及附屬結構淋巴癌反
應性淋巴增生非典型淋巴增生
1 新光吳火獅紀念醫院眼科
通訊作者林友祺 電子信箱 yuchi067gmailcom
Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh 120
Submitted March 26 2020
Final version accepted April 16
2020
Case Report
Hyperacute intramembranous hemor-
rhage after burr hole craniostomy for
chronic subdural hematoma
Cite as Meng-Chi Lin Jui-Ming
Sun Yu-Hao Chen Cheng-Ta
Hsieh
Hyperacute intramembranous
hemorrhage after burr hole crani-
ostomy for chronic subdural he-
matoma Fu-Jen Journal of Medi-
cine 3(4) 120-125 2020
DOI
103966181020932020091803004
Meng-Chi Lin1 Jui-Ming Sun23 Yu-Hao Chen24 Cheng-Ta
Hsieh567
1Department of Surgery Zuoying Branch Kaohsiung Armed Forces
General Hospital Kaohsiung 813 Taiwan 2Section of Neurosurgery Department of Surgery Chia-Yi Christian
Hospital Chia-Yi City 600 Taiwan 3Department of Biotechnology Asia University Taichung City 41354
Taiwan 4Chung-Jen Junior College of Nursing Health Sciences and Manage-
ment Chia-Yi Country 62241 Taiwan 5Division of Neurosurgery Department of Surgery Sijhih Cathay Gen-
eral Hospital New Taipei City 22174 Taiwan 6Department of Medicine School of Medicine Fu Jen Catholic Univer-
sity New Taipei City 24205 Taiwan 7Department of Neurological Surgery Tri-Service General Hospital
National Defense Medical Center Taipei 114 Taiwan
Corresponding author E-mail address
nogormail2000comtw (Cheng-Ta Hsieh)
ABSTRACT
Burr hole craniostomy with closed-system drainage is an effective and common neurosurgical procedure to manage chronic subdural hematoma Postoperative hem-orrhage a well-known but infrequent complication may result in increased neurolog-ical deficits However hyperacute intramembranous hemorrhage within the inner and outer membrane of hematoma after burr hole craniostomy with irrigation and closed-system drainage has not been described previously Herein we report a case of postoperative spontaneous hyperacute intramembranous hemorrhage after burr hole craniostomy with closed-system drainage to manage a chronic subdural hematoma we subsequently discuss the possible pathophysiological mechanisms and review the relevant literature
Keywords Chronic subdural hematoma acute subdural hematoma bleeding burr hole craniostomy
drainage
Fu-J
Meng
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Vol 3 No 4 2
Acute intram
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EFERENCRohde VComplicatiand closedsubdural analysis of
active bleedinerved Histolonized hematots and capilla
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ON oman had a hi
gular medicatig nutritional ma lucidum referred to ohe became proxamination rScale ratings wgth score in th
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motor oilndashlikespace was uncal and outer marea was irrigaough the subdusystem was plcreased the rel space An emracute hemorrfrom the frone (Figure 2B
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CES V Graf Gons of burr-
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Vol 3 No 4 2
Acute intram
Yu-Hao Chen
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displaying a m
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2020
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Cheng-Ta Hs
red type of CS
midline shift
ns (A) Bone w
(white arrow)
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ieh
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rrow) in the rig
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123
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Vol 3 No 4 2
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124
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Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh
125
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
慢性硬腦膜下出血進行鑽顱引流手術造成超急性夾膜內出
血
林孟楫 1孫瑞明 23陳昱豪 24謝政達 567
中文摘要
鑽顱併封閉系統引流手術是治療慢性硬腦膜下出血患者一種有效且常見的
神經外科手術方式術後出血可能導致神經功能缺損惡化是眾所周知但不常見
的併發症之一然而至今仍未有鑽孔併封閉系統引流造成原本慢性硬腦膜血
塊內膜和外膜間急性夾膜間出血案例在這裡我們報告一例慢性硬腦膜下出
血病患者接受鑽顱併封閉系統引流手術治療造成術後急性夾膜間出血我們在
本文中討論可能的致病機制並回顧相關文獻
關鍵字慢性硬腦膜下出血急性硬腦膜下出血出血鑽顱術引流
1國軍高雄總醫院左營分院 外科部
2崇仁醫護管理專科學校
3亞洲大學 生物科技學系
4戴德森醫療財團法人嘉義基督教醫院 外科部 神經外科
5汐止國泰綜合醫院 神經外科
6輔仁大學 醫學系
7 國防醫學院 三軍總醫院 神經外科
通訊作者謝政達 電子信箱 nogormail2000comtw
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
126
Submitted January 21 2020
Final version accepted July 08
2020
Case Report
Hamartoma of the breast A case report
Cite as Hsuan-An Chen
Cheng-Yu Lo Shih-Hung Huang
Chin-Lung Lin
Hamartoma of the breast A case
report Fu-Jen Journal of Medicine
3(5) 126-130 2020
DOI
103966181020932020091803005
Hsuan-An Chen1 Cheng-Yu Lo
3 Shih-Hung Huang
3 Chin-Lung
Lin2
1Department of Surgery Cathay General Hospital Taipei Taiwan
2Department of General Surgery Cathay General Hospital Taipei Tai-
wan
3Department of Pathology Cathay General Hospital Taipei Taiwan
Corresponding author E-mail address
lungyungmailcom (Chin-Lung Lin)
ABSTRACT
Breast hamartoma is an uncommon benign tumor rarely associated with malignancy An
excision and histological examination is necessary for the differential diagnosis We report
a case of a 49-year-old female patient presenting with a lump in the right breast Ultrasound
examination which demonstrated a 4411 cm hypoechoic lesion with lipoma Partial mas-
tectomy was arranged and the diagnosis of a hamartoma was confirmed by the histological
examination
Keywords Breast tumor Hamartoma Ultrasound
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
127
INTRODUCTION The hamartoma is a benign tumor-like lesion
that can affect various organs of the body in-
cluding lungs kidneys skin and more rarely the
breast In 1981 the hamartomas were recognized
in the WHO classification[1] They are defined
as well-demarcated mass of mammary ducts and
lobules containing varying amounts of fibrous
and adipose tissue and producing a distinctive
mammographic image
CASE REPORT A 49 year-old female had past history of left
breast mastitis with abscess status post partial
mastectomy This time she presented to our out
patient clinic for breast examination Physical
examination revealed a painless palpable mova-
ble and painless lump at upper outer quadrant of
right breast The risk of breast cancer was not
noted and the patient did not have any family
history of breast cancer The patient also denied
any trauma history before Ultrasound examina-
tion was arranged which demonstrated a 4411
cm hypoechoic lesion with lipoma at 3 oclock 2
cm from nipple of right breast and multiple hy-
poechoic nodules of various size in both breasts
and there was no suspicious axillary lymph
nodes noted (Figure1) Surgical treatment was
arranged partial mastectomy of right breast
harmartoma was successfully performed A 32 x
31 x 21 cm tumor was completely excised
Grossly examination showed a gray to yellow
and firm to fatty The diagnosis of a hamartoma
was confirmed by the histological examination
Microscopically sections of the breast lesion
show mammary hamartoma composed of ducts
lobules with interlobular fibrous tissue and adi-
pose tissue Fibrocystic change apocrine meta-
plastic ducts and scattered foci of adenosis are
noted The overall lobulocentric architecture and
the 2-cell pattern of the epithelium are preserved
columnar cell change and focal microcalcifica-
tion are present (Figure2) Based on submitted
biopsy specimen in-situ or invasive tumor cells
are not identified
DISCUSSION Hamartoma of the breast is a benign tumor like
nodule it was also known as fibroadenolipoma
lipofibroadenoma or adenolipoma based on its
predominant components It was composed of
varying amounts of glandular adipose and fi-
brous tissue[2] Hamartomas were first described
in 1971 by Arrigoni et al in a study of 10 patients
which breast tumors clinically and grossly re-
sembled fibroadenomas[3]
A higher predominance of tumors exists in fe-
males compared with males Hamartomas are
slowly-growing lesions with the diameter rang-
ing from 2 cm to 5 cm sometimes hamartomas
can reach giant diameter [4]
The clinical diagnosis of hamartoma is based on
the findings from mammography sonography
and histology examinations The hamartomas are
usually incidentally diagnosed by the women
older than 40 year-old starting mammography
screening
On physicial examination harmatomas are usu-
ally occult painless they may be as large mo-
bile soft to firm masses[5] Ultrasound showed
well capsulated mass with echogenic rim and
internal heterogeneity Mammography exam
showed well-circumscribed round to oval
masses containing fat and soft tissue densities
with a thin radiopaque pseudocapsule The
pseudocapsule results from displacement of
breast parenchyma by the tumor [56] In Pa-
thology finding microglandular adenosis is pre-
sent in fibroadipose stroma surrounded by a thin
fibrous capsule It composed of a combination of
epithelial and stromal elements usually with
normal ducts or lobules although variations of
normal tissue may also be seen Fibroadenoli-
poma myoid hamartoma and chondrolipoma are
histological variations of hamartomas depend-
ing on the proportion of normal breast tissue
elements[7]
Malignancy associated with hamartomas are
very rare[8] However it has been reported
hamartomas develop into carcinoma Malignant
transformation can occur as a result of cellular
atypia in the epithelial component of the mass[9]
Surgical removal is the curative method for
breast hamartomas[10] Diagnostic material such
as mammography ultrasonography or core nee-
dle biopsy may not give the definitive diagnosis
Therefore surgical excision and histological
examination is necessary for differential diagno-
sis[111213]
Although it is rare hamartoma can be seen along
with malignancy as it is formed from similar
components of breast tissue Therefore careful
diagnosis and appropriate management including
surgery are required
REFERENCES 1 World Health Organization (1981)
Histological typing of breast tumors In
International histological classification of
tumors 1981 2nd ed
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
128
2 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11435ndash449
2006
3 ArrigoniMG DockertyMB JuddES
The identificationand treatment of
mammary hamartoma Surg Gynecol
Obstet1971 133 577-82
4 Sanal HT Ersoz N Altinel O Unal E Can
C Giant hamartoma of the breast Breast J
2006 12 84-85
5 Feder JM de Paredes ES Hogge JP
Wilken JJ Unusual breast lesions
radiologic-pathologic correlation
Radiographics 1999 19S11ndashS26
6 Murat A Ozdemir H Yildirim H Poyraz
AK Ozercan R Hamartoma of the breast
Australas Radiol 200751 Spec NoB37ndash
9
7 Fisher CJ Hanby AM Robinson L Millis
RR Mammary hamartoma-a review of 35
cases Histopathology 1992 20 99-106
8 Choi N Ko ES Invasive ductal carcinoma
in a mammary hamartoma case report and
review of the literature Korean J Radiol
2010 Nov-Dec11(6)687-91
9 Lee EH Wylie EJ Bourke AG Bastiaan
De Boer W Invasive ductal carcinoma
arising in a breast hamartoma two case
reports and a review of the literature Clin
Radiol 2003 58 80-3
10 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11 435 ‑449
2006
11 Coyne J Hobbs FM Boggis C Harland R
Lobular carcinoma in a mammary
hamartoma J Clin Pathol 199245936ndash
937
12 G M K Tse B K B Law T K F Ma A B W
Chan Hamartoma of the breast a
clinicopathological review J Clin Pathol
200255951ndash954
13 RAAmir SSheikh BreasthamartomaA
report of 14cases of an under-recognized
and under-reported entity International
Journal of Surgery Case Reports
22(2016)1ndash4
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
129
FIGURES
Figure 1 Ultrasound shows a 4411 cm hypoechoic lesion with lipoma at 3 oclock 2 cm from nipple
of right breast
Figure 2 Photomicrograph shows mammary hamartoma composed of ducts lobules with interlobular
fibrous tissue and adipose tissue
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
130
Hamartoma of the breast A case report
乳房錯構瘤罕見個案報告
陳宣安 1羅承裕 3黃世鴻 3林錦龍 2
中文摘要
乳房錯構瘤是一種罕見之乳房良性腫瘤切除手術及病理化驗來做鑑別診斷
我們報告一位 49歲女性以可觸摸到無痛性右側乳房腫塊為臨床表徵超音波
看到一個邊緣清楚低迴音的腫塊病患接受手術切除病灶病理診斷證實為乳
房錯構瘤
關鍵字乳房腫瘤錯構瘤超音波攝影
1國泰綜合醫院外科部
2國泰綜合醫院一般外科
3國泰綜合醫院病理科
通訊作者林錦龍 電子信箱 lungyungmailcom
Fu-Jen Journal of Medicine
Mission and Goals
The Fu-Jen Journal of Medicine (FJJM) is a peer-reviewed journal which
aims to enhance research quality of staffs in the College of Medicine Fu Jen
Catholic University The journal publishes original investigations across a
wide range of medical disciplines including original research articles in basic
and clinical sciences case reports review articles brief reports and letter
to the editor FJJM is now issued by the Center of Medical Education in the
College of Medicine Fu Jen Catholic University To promote journal quality
the manuscript submitted to FJJM after August first 2015 has to be prepared
in English to meet the international standards
Issue Date
Publication Date
Institution
December 01 2003
September 30 2020
College of Medicine Fu Jen Catholic University
Honorable publisher Han-Sun Chiang
Publisher Ping-Keung Yip
Editor-in-chief Ming-Chieh Ma
Associate Editors Yu-Wen Lin
Editors
Telephone (02) 2905-3477
Address Center for Medical Education College of Medicine Fu Jen
Catholic University
No 510 Zhongzheng Rd Xinzhuang Dist New Taipei City
24205 Taiwan
Su-Jane Wang Chi-Chung Wang Chih-Ming Ho
Yih-Jing Lee Chih-Shung Wong Tze-Wah Kao
Chi-Feng Hung Rung-Fen Feng Chee-Fah Chogn
Chia-Chen Lu Zai-Ting Yeh
Dee Pei Chih-Kuang Liu
Hen-Hui Lien Chien-Hsiou Liu
Chun-Hou Liao Yi-Ju Tsai Sheng-Wen Teng
Chia-Ting Su
- 9月封面
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- 9月封底
-
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 107
Figure 3 Supervision (Direct Supervisory Chain of Command) (N=40)
Figure 4 Organization Influence (Upper-Level Management Command Level) (N=40)
114 (71)
114 (71)
214 (143)
314 (214)
1314 (929)
1440 (350)
511 (455)
511 (455)
711 (636)
1140 (275)
47 (571)
67 (857)
740 (175)
0 5 10 15 20 25 30 35 40
Selected Individual with Lack of Proficiency
Improper Role‐modeling
Failed to Provide Proper Training
Failed to IdentifyCorrect Risky or Unsafe Practices
SupervisoryCommand Oversight Inadequate
Performed Inadequate Risk Assessment ‐Formal
Selected Individual with Lack of Current or Limited Experience
Authorized Unnecessary Hazard
Allowing Unwritten Policies to Become Standard
Failure to Enforce Existing Rules
Supervisory Violations
Planned Inappropriate Operations
Inadequate Supervision
12 (500)
12 (500)
240 (50)
110 (100)
510 (500)
1040 (250)
11 (1000)
140 (25)
18 (125)
18 (125)
38 (35)
48 (500)
840 (200)
0 5 10 15 20 25 30 35 40
Organizational Over-confidence or Under-confidence in Equipment
Organizational Culture (attitude actions) Allows for Unsafe TaskMission
Purchasing or Providing Poorly Designed or Unsuitable Equipment
Organizational ProgramPolicy Risks not Adequately Assessed
Failure to Provide Adequate Manning Staffing Resources
Failure to remove inadequate worn-out equipment in timely manner
Inadequate infrastructure
Command and control resources are deficient
Failure to provide adequate operational information resources
Resource Problems
Personnel Selection amp Staffing
Policy and Process Issues
ClimateCulture Influences
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 108
Supplement Table 1- HFACS Content of Human Factor Analysis Classifi-
cation System [9] Tier main level sub-item nano code
Tier 1 Unsafe Acts
Perfor-
mance-Based
Errors
Unintended operation of equipment
Checklist not followed correctly
Procedure not followed correctly
Over-controlledunder-controlled aircraftvehiclesystem
Breakdown in visual scan
Rushed or delayed a necessary action
Judgment amp De-
cision-Making
Errors
Inadequate real‐time risk assessment
Failure to prioritize tasks adequately
Ignored a cautionwarning
Wrong choice of action during an operation
Violations
Performs work-around violation
Commits widespreadroutine violation
Extreme violation-lack of discipline
Tier 2 Preconditions
Environment
Physical environment
Environmental conditions affecting vision
Vibration effects vision or balance
Heatcold stress impairs performance
External force of object impeded an individualrsquos
movement
Lights of other vehiclevesselaircraft affected vision
Noise interference
Technological environment
Seat and restraint system problems
Instrumentation amp warning system issues
Visibility restrictions (not weather related)
Controls and switches are inadequate
Automated system creates unsafe situation
Workspace incompatible with operation
Personal equipment interference
Communication equipment inadequate
Physical and
Mental State
Physical problem
Substance effects (alcohol supplements medications
drugs)
Loss of consciousness (sudden or prolonged onset)
Physical illnessinjury
Fatigue
Inadequate adaptation to darkness
Dehydration
Body sizemovement limitations
Physical strength amp coordination (inappropriate for
task demands)
Nutritiondiet
State of mind
Psychological problem
Life stressors
Emotional state
Personality style
Overconfidence
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 109
Pressing
Complacency
Motivation
Motivational exhaustion (burnout)
Sensory misperception
Motion illusion-kinesthetic
Turning illusionbalance-vestibular
Visual illusion
Misperception of changing environment
Misinterpreted misread instrument
Misinterpretation of auditorysound cues
Spatial disorientation
Temporaltime distortion
Mental awareness
Not paying attention
Fixation
Task overunder saturation
Confusion
Negative habit transfer
Distraction
Geographically lost
Interferenceinterruption
Technical or procedural knowledge not retained after
training
Inaccurate expectation
Teamwork
Failure of crewteam leadership
Inadequate task delegation
Rankposition intimidation
Lack of assertiveness
Critical information not communicated
Standardproper terminology not used
Failed to effectively communicate
Taskmission planningbriefingdebriefing inadequate
Tier 3 Supervision
Supervisory Vio-
lations
Failure to enforce existing rules
Allowing unwritten policies to become standard
Directed individual to violate existing regulations
Authorized unqualified individuals for task
Planned Inappro-
priate Operations
Directed task beyond personnel capabilities
Inappropriate team composition
Selected individual with lack of current or limited experience
Performed inadequate risk assessment ‐formal
Authorized unnecessary hazard
Inadequate Su-
pervision
Supervisorycommand oversight inadequate
Improper role‐modeling
Failed to provide proper training
Failed to provide appropriate policyguidance
Personality conflict with supervisor
Lack of supervisory responses to critical information
Failed to identifycorrect risky or unsafe practices
Selected individual with lack of proficiency
Tier 4 Organizational
Influences
Resource Prob-
lems
Command and control resources are deficient
Inadequate infrastructure
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 110
Failure to remove inadequate worn-out equipment in timely
manner
Failure to provide adequate operational information resources
Fail to provide adequate funding
Personnel Selec-
tion amp Staffing
Personnel recruiting amp selection policies are inadequate
Failure to provide adequate manning staffing resources
Policy amp Process
Issues
Pace of ops-tempoworkload
Organizational programpolicy risks not adequately assessed
Provided inadequate procedural guidance or publications
Organizational (formal) training is inadequate or unavailable
Flawed doctrinephilosophy
Inadequate program management
Purchasing or providing poorly designed or unsuitable equip-
ment
ClimateCulture
Influences
Organizational culture (attitude actions) allows for unsafe
taskmission
Organizational over-confidence or under-confidence in equip-
ment
Unit missionaircraftvehicleequipment change or unit deacti-
vation
Organizational structure is unclear or inadequate
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 111
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
以 HFACS重新檢視根本原因分析案例挖掘造成醫療不良
事件之人為因素
鄭伃洵 1洪聖惠 12柯彤文 3王拔群 14
中文摘要
背景醫療不良事件(AMEs)的管理是促進病人安全的基石根本原因分析
(RCA)是探討重大病人安全不良事件問題但是由於無法解釋更廣泛的因素而受
到限制本研究使用人為因素分類與分析工具(HFACS)回溯審視醫療不良事件
以了解影響醫療不良事件的人為因素及各層面中錯誤原因之分佈或系統性問題
方法本研究回溯 2012-2016年間有做過根本原因分析之醫療不良事件以連續
性取樣方式(continuous sampling)收集 40例醫療不良事件以人為因素分類與分
析工具(HFACS)去系統性的挖掘每件案例發生錯誤之原因結果在行為層面中
分析結果主要為基礎技能錯誤(95)判斷和決策錯誤(875)其中在基礎技能
錯誤當中以未依程序作業執行(816)及未如預期設備操作(50)佔多數判斷和
決策錯誤中以現場風險評估不確實(686)及採取錯的步驟行為(686)佔多數
而在先決條件層面中以團隊合作(275)為主要因素包含溝通不良(818)及重
要訊息未以正確的方式即時傳達(727)佔多數在監督層面當中以監督不周
(929)或監督不妥當(929)為主要因素在組織政策和流程方面(50)以組織
系統的政策風險未充分評估(35)為主要因素結論本研究進一步了解醫療不
良事件在過去使用根本原因分析未探討到的人為因素反映出潛在的監督組織
行為或系統性的問題促進病人安全預防錯誤再發生
關鍵字病人安全醫療不良事件根本原因分析人為因素
1國泰醫療財團法人國泰綜合醫院 品質管理部
2國立臺灣大學健康政策與管理研究所
3振興醫療財團法人振興醫院 醫療品質管理中心
4輔仁大學醫學院
通訊作者王拔群 電子信箱 drtonyseednettw
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin 112
Submitted January 20 2020
Final version accepted April13
2020
Case Report
Juvenile Caruncular Atypical Lymphoid
Proliferation ndash A Rare Case Report
Cite as Hua-Wei Shih Yu-Chi Lin
Juvenile Caruncular Atypical
Lymphoid Proliferation ndash A Rare
Case Report Fu-Jen Journal of
Medicine 3(3) 112-119 2020
DOI
103966181020932020091803003
Hua-Wei Shih1 Yu-Chi Lin
1
1Department of Ophthalmology Shin Kong Wu Ho-Su Memorial Hos-
pital Taipei City Taiwan
Corresponding author E-mail address
yuchi067gmailcom (Yu-Chi Lin)
ABSTRACT
Lesions of the caruncle are very rare Most caruncular lesions are benign though there were still few reported malignant lesions Ocular adnexal lymphoproliferative disease (OALD) one of the differential diagnosis of caruncular lesion is seldom seen in young pa-tient In this article we report a 16-year-old boy with recurrent caruncular atypical lym-phoid proliferation We discuss the epidemiology clinical features images histomorpholo-gy and treatment between ocular adnexal lymphomas (OAL) and reactive lymphoid hyper-plasia (RLH)
Keywords caruncular lesion ocular adnexal lymphoproliferative disease ocular adnexal lymphoma
reactive lymphoid hyperplasia atypical lymphoid proliferation
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
113
INTRODUCTION Lesions of the caruncle are very rare Differen-
tial diagnosis includes nevus myeloproliferative
disorders tumors inflammation infection cysts
vascular lesions and fibrous Biopsy is essential
for diagnosis Levy J et al reported ocular ad-
nexal lymphoproliferative disease (OALD) was
relatively uncommon diagnosis among caruncu-
lar lesions [1]
OALD was seldom described in Asian popula-
tion especially for young age C-Y Cheng re-
ported age-standardized incidence of ocular
adnexal lymphomas (OAL) in Taiwan from 1979
to 1996 was below 07 per million per year and
mean age was 531 years old [2] In 2015 five
Taiwanese cases of OAL whose age ranging
from 45 to 64 were presented [3] However
there were few cases of conjunctival OAL or
RLH in Chinese pediatric patient
Here we present a case of 16-year-old boy with a
caruncular mass at his left eye with recurrence
one month after excision We describe his clini-
cal symptoms photographs pathological results
management and follow-up clinical course in
this report
CASE REPORT A 16-year-old healthy boy presented a mass
lesion at his left eye caruncle accompanied with
the symptom of tearing for one month (Figure 1)
He had no ocular pain no itchiness no blurred
vision no night sweating no fever and no body
weight loss The patient denied systemic diseas-
es and histories of surgery His bilateral best
corrected visual acuity (BCVA) were 66 and
intraocular pressure (IOP) were both within
normal range There were no remarkable find-
ings for his cornea lens fundus and physical
examination Excision was performed and the
mass was soft with fluid inside therefore con-
junctival pyogenic cyst was our initial diagnosis
However one month after the excision a pro-
truding mass recurred at the patientrsquos nasal can-
thus of left eye (Figure 2) There were some
differences compared to previous condition At
the first time the soft mass was contained in a
well-defined cyst wall which more favored py-
ogenic granulation However after short period
of recurrence solid consistency and unclear
margin were found which favored malignancy
Besides the mass partially involved beyond the
gray line of nasal part lower eyelid whereas last
time the cyst mainly extended from conjunctiva
of caruncle The second excisional biopsy was
performed Pathologic examination demonstrat-
ed abundant atypical lymphoid proliferation
(Figure 3A 3B) Immunohistochemical studies
showed that the lymphoid aggregation was
composed predominantly of CD20-positive cells
(Figure 3C) focal positive staining of CD3
(Figure 3D) CD5 CD23 CD10 and negative
staining of cyclin-D1 Unfortunately the cellular
morphology was difficult to be evaluated due to
marked crushing artifact Thus malignant lym-
phoma cannot be excluded totally
Orbital computed tomography (CT) showed a
lesion of soft tissue density at medial canthus of
left orbit without obvious nasolacrimal duct or
bony invasion (Figure 4A) Magnetic resonance
imaging (MRI) with contrast showed strong
enhancement at left medial canthus region (Fig-
ure 4B) There was no remarkable finding in the
systemic workup including complete blood
count and differential count biochemical pro-
files and 18F-fluoro-2-deoxyglucose positron
emission tomographycomputed tomography
(18F-FDG PETCT) indicating no evidence of
systemic involvement
After the second excision we preferred con-
servative management for him due to the uncer-
tainty of malignancy and to avoid side effects
from aggressive treatment No sign of recurrence
was noted after 10 months of observation The
follow-up photo was taken at three months after
the second operation (Figure 5)
DISCUSSION Ocular adnexal lymphoproliferative disease
(OALD) consists of the spectrum of lymphoid
disease affecting the tissues surrounding the eye
including ocular adnexal lymphomas (OAL) and
lymphoid hyperplasia (LH) [4] The conjunctiva
is an important location for extranodal lympho-
ma development which comprises 25 of OAL
[5]
OAL can be grouped into two categories based
on their appearance of cells under the micro-
scope low-grade and high-grade [6] Extranodal
marginal zone lymphoma of mucosa-associated
lymphoid tissue (EMZLMALT) is the most
common subtype of OAL followed by follicular
lymphoma [7-9] Both of the above are
low-grade lymphomas
LH can be further divided by histopathology into
reactive lymphoid hyperplasia (RLH) and atypi-
cal lymphoid hyperplasia (ALH) RLH has to-
tally benign morphology and immunophenotype
whereas ALH has borderline lesions between
RLH and lymphoma [10] OAL and LH are
mostly seen in patients with age between 50-70
years old There are rare cases in pediatric group
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
114
[71011] In the C-Y Chengrsquos statistical report of
OAL in Taiwan only 8 patients were younger
than 15 years old among the 101 cases of ocular
lymphoma [2] According to an US study inci-
dence rates of OAL were analyzed in different
age groups the group of age over 50 had the
highest incidence rate of 574 per million per-
son-years while the 0-19 age group had the
lowest incidence rate of 009 per million per-
son-years [12] The incidence of LH was even
less than OAL [13]
Patients with OALD may be asymptomatic or
with symptoms of proptosis eyelid swelling a
palpable painless mass or conjunctival salmon
patch Diplopia visual loss pain or inflamma-
tion occurred less frequently implying more
aggressive features [714]
Orbital LH is not distinguishable from low-grade
lymphoma radiologically They both typically
present a round or lobulated mass that diffusely
moderately enhances with contrast and usually
shows homogenous hypointense or isointense to
muscle barely invasion to bone or nervous sys-
tem [10] Atypical appearances including inho-
mogeneous calcification or bony changes may
be seen in high-grade lymphoma case reports
such as ocular adnexal diffuse large B-cell lym-
phoma (DLBCL) which is one of the more ag-
gressive type of OAL [7] Whole body PET is
used for not only the evaluation of systemic
involvement but also the standard for staging
lymphoma Our patientrsquos image studies revealed
neither obvious local invasion nor systemic ma-
lignancy indicating high-grade lymphoma was
less likely Low-grade lymphoma and benign
reactive lymphoid hyperplasia were still under
consideration
Histomorphology analysis and immunohisto-
chemistry (IHC) are essential for diagnosis
Flow cytometry and polymerase chain reaction
(PCR) technique are also applied to help differ-
entiate from RLH and OAL [1016] Our case
had immunohistochemical profile of positivity
for CD20 predominantly positivity focally for
CD3 CD5 CD10 CD23 and negativity for cy-
clin-D1 BCL-6 staining was not performed in
our casersquos biopsy Thus according to the IHC
report RLH ALH and follicular lymphoma are
probable diagnosis of our patient
Radiation therapy is the standard treatment for
low-grade OAL that is classified as T1N0M0 or
T2N0M0 according to the AJCC criteria [15]
İncesoy-Ouml zdemir S et al reported a 10-year-old
boy diagnosed of MALT lymphoma who was
treated with local radiotherapy (36 Gy) and
there were no local or systemic recurrences dur-
ing his nearly four-year follow-up [17] Another
case report represented a 21-year-old man of
conjunctival follicular lymphoma treated with
surgical excision only showing no evidence of
recurrence after 8 months follow-up [18] Other
treatment options for pediatric and juvenile OAL
were performed in some case reports including
intravenous rituximab intralesional interfer-
on-α-2b topical interferon a6 systemic doxycy-
cline surgical excision and postoperative local
cryotherapy [15]
Treatment for young conjunctival RLH was less
discussed in the past In a case series article
three children (9 13 14 years old respectively)
of RLH received surgical resection without fur-
ther postoperative management and no signs of
recurrence were noted during follow-up [19]
Short-term topical and oral corticosteroids after
surgical excision were prescribed in two pediat-
ric RLH patients for their small residual mass
However poor response in both cases was nota-
ble [20]
Our patient declined to receive radiotherapy or
any further postoperative treatment mainly due
to his concerning of possible side effects (such
as dry eye and cataract)
CONCLUSION We present a rare case of caruncle mass in this
report OALD is one of the relatively uncommon
diagnosis among caruncular lesions OALD
includes benign RLH and malignant OAL
which are both mainly seen in elderly patients
even rarer in pediatric or juvenile group
The standard treatment for low-grade OAL and
RLH in young patents are still debatable How-
ever long-term follow-up is suggested for both
OAL and RLH patients Though RLH has a be-
nign and self-limited course risk of malignant
transformation is possible
REFERENCES 1 Levy J Ilsar M Deckel Y et al Lesions of
the caruncle a description of 42 cases and
a review of the literature Eye
200923(5)1004-1018
2 C-Y Cheng and W-M Hsu Incidence of
eye cancer in Taiwan an 18-year review
Eye 200418152-158
3 Chui-Lien Tsen Muh-Chiou Lin
Youn-Shen Bee et al Ocular adnexal
lymphoma Five case reports and a
literature review Taiwan Journal of
Ophthalmology 20155(2)99-102
4 Liesegang TJ Ocular adnexal
lymphoproliferative lesions Mayo Clin
Proc 199368(10)1003-1010
5 Kirkegaard MM Coupland SE Prause JU
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
115
et al Malignant lymphoma of the
conjunctiva Surv Ophthalmol
201560(5)444-458
6 Stacy RC Jakobiec FA Schoenfield L et
al Unifocal and multifocal reactive
lymphoid hyperplasia vs follicular
lymphoma of the ocular adnexa Am J
Ophthalmol 2010150(3)412-426
7 Sullivan TJ Ocular Adnexal
Lymphoproliferative Disease In Guthoff
RF Katowitz JA eds Oculoplastics and
Orbit Berlin Heidelberg Springer
20101-19
8 White Valerie A Understanding and
Classification of Ocular Lymphomas
Ocular Oncology and Pathology
20195379-386
9 Stefanovic A Lossos IS Extranodal
marginal zone lymphoma of the ocular
adnexa Blood 2009114(3)501-510
10 Andrew NH Coupland SE Pirbhai A et al
Lymphoid hyperplasia of the orbit and
ocular adnexa A clinical pathologic review
Surv Ophthalmol 201661(6)778-790
11 Ferry JA1 Fung CY Zukerberg L et al
Lymphoma of the ocular adnexa A study
of 353 cases Am J Surg Pathol
200731(2)170-184
12 WM Hassan MS Bakry HM Hassan et al
Incidence of orbital conjunctival and
lacrimal gland malignant tumors in USA
from Surveillance Epidemiology and End
Results 1973-2009 Int J Ophthalmol
20169(12)1808-1813
13 Ajay A Rao John H Naheedy James Y-Y
Chen et al A Clinical Update and
Radiologic Review of Pediatric Orbital
and Ocular Tumors Journal of Oncology
2013(9)975908
14 Sullivan TJ Whitehead K Williamson R
et al Lymphoproliferative disease of the
ocular adnexa a clinical and pathologic
study with statistical analysis of 69
patients Ophthal Plast Reconstr Surg
200521177-188
15 Tanenbaum RE Galor A Dubovy SR et al
Classification diagnosis and management
of conjunctival lymphoma Eye Vis (Lond)
2019622
16 Olga Klavdianou Georgios Kondylis
Vasileios Georgopoulos et al Bilateral
benign reactive lymphoid hyperplasia of
the conjunctiva a case treated with oral
doxycycline and review of the literature
Eye Vis (Lond) 2019626
17 İncesoy-Ouml zdemir S Yuumlksek N Bozkurt C
et al A rare type of cancer in children
extranodal marginal zone B-cell (MALT)
lymphoma of the ocular adnexa Turk J
Pediatr 201456(3)295-298
18 Lynn J Poole Perry Frederick A Jakobiec
Peter A D Rubin Conjunctival Pediatric
Follicular Lymphoma Arch Ophthalmol
2012130(7)941-943
19 Abdullah Al-Mujaini Upender Wali
Anuradha Ganesh1 et al Ocular Adnexal
Reactive Lymphoid Hyperplasia in
Children Middle East Afr J Ophthalmol
201219(4)406-409
20 McLeod SD Edward DP Benign
lymphoid hyperplasia of the conjunctiva in
children Arch Ophthalmol
1999117(6)832-835
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
116
FIGURES
Figure 1 Slit lamp image of a mass lesion at the patientrsquos left eye caruncle for one month
Figure 2 One month after the first excision a protruding mass recurred at the patientrsquos nasal canthus
of left eye It partially involved beyond the gray line of nasal part lower eyelid
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
117
Figure 3 Histomorphology analysis and immunohistochemistry study of the caruncular lesion Abun-
dant atypical lymphoid proliferation presented in low-power photomicrograph (A) and
high-power photomicrograph (B) under hematoxylin-eosin staining The lymphoid aggrega-
tion was composed predominantly of CD20-positive cells (C) and focal positive staining of
CD3 (D)
Figure 4 Non-contrast orbital computed tomography showed a lesion of soft tissue density at medial
canthus of left orbit without obvious nasolacrimal duct or bony invasion (A) Magnetic reso-
nance imaging with contrast showed strong enhancement at left medial canthus region (B)
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
118
Figure 5 The follow-up photo were taken at three months after the second excision showing no signs
of recurrence
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
119
Juvenile Caruncular Atypical Lymphoid Proliferation ndash A Rare Case Report
罕見病例報告mdash青少年之淚阜非典型淋巴增生
施驊瑋 1林友祺 1
中文摘要
淚阜病灶相當罕見大部分為良性病灶眼睛及附屬結構淋巴增生疾病為其
鑑別診斷之一非常少見於年輕人或兒童我們報告一位 16歲的健康男性因
左眼淚阜無痛性腫塊接受切除手術卻於術後一個月復發執行第二次切除手術
後門診追蹤十個月未再復發此案例表現了部分良性與部分惡性腫瘤的特徵
我們針對反應性淋巴增生眼睛及附屬結構淋巴癌兩個疾病做討論及文獻回顧
關鍵字淚阜病灶眼睛及附屬結構淋巴增生疾病眼睛及附屬結構淋巴癌反
應性淋巴增生非典型淋巴增生
1 新光吳火獅紀念醫院眼科
通訊作者林友祺 電子信箱 yuchi067gmailcom
Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh 120
Submitted March 26 2020
Final version accepted April 16
2020
Case Report
Hyperacute intramembranous hemor-
rhage after burr hole craniostomy for
chronic subdural hematoma
Cite as Meng-Chi Lin Jui-Ming
Sun Yu-Hao Chen Cheng-Ta
Hsieh
Hyperacute intramembranous
hemorrhage after burr hole crani-
ostomy for chronic subdural he-
matoma Fu-Jen Journal of Medi-
cine 3(4) 120-125 2020
DOI
103966181020932020091803004
Meng-Chi Lin1 Jui-Ming Sun23 Yu-Hao Chen24 Cheng-Ta
Hsieh567
1Department of Surgery Zuoying Branch Kaohsiung Armed Forces
General Hospital Kaohsiung 813 Taiwan 2Section of Neurosurgery Department of Surgery Chia-Yi Christian
Hospital Chia-Yi City 600 Taiwan 3Department of Biotechnology Asia University Taichung City 41354
Taiwan 4Chung-Jen Junior College of Nursing Health Sciences and Manage-
ment Chia-Yi Country 62241 Taiwan 5Division of Neurosurgery Department of Surgery Sijhih Cathay Gen-
eral Hospital New Taipei City 22174 Taiwan 6Department of Medicine School of Medicine Fu Jen Catholic Univer-
sity New Taipei City 24205 Taiwan 7Department of Neurological Surgery Tri-Service General Hospital
National Defense Medical Center Taipei 114 Taiwan
Corresponding author E-mail address
nogormail2000comtw (Cheng-Ta Hsieh)
ABSTRACT
Burr hole craniostomy with closed-system drainage is an effective and common neurosurgical procedure to manage chronic subdural hematoma Postoperative hem-orrhage a well-known but infrequent complication may result in increased neurolog-ical deficits However hyperacute intramembranous hemorrhage within the inner and outer membrane of hematoma after burr hole craniostomy with irrigation and closed-system drainage has not been described previously Herein we report a case of postoperative spontaneous hyperacute intramembranous hemorrhage after burr hole craniostomy with closed-system drainage to manage a chronic subdural hematoma we subsequently discuss the possible pathophysiological mechanisms and review the relevant literature
Keywords Chronic subdural hematoma acute subdural hematoma bleeding burr hole craniostomy
drainage
Fu-J
Meng
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TRODUConic subdural t common contervention [1
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of Medicine V
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(Figure 2B)membranecto
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Vol 3 No 4 2
Acute intram
Yu-Hao Chen
CSDH) one ofuiring neurosugressive collechematomas in
outer and ievidence suggwith or wite and widely ut and that it ] Recurrence r this surgerywever the hyng after burr ely been discucase of a pa
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previous CS
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ISCUSSIO61-year-old won without regd been takingning Ganodermrs She was tment when shurological exasgow Coma S
muscle strengs was 45 on
ale Her laborh the normal rnoted Brain
n revealed Ch a marked m
ently she receniostomy withinage ring surgery mthe subdural sn of the duramatoma The arile saline throsed drainage swever this inm the subduraealed a hyperdural space fniostomy siteniotomy withthe hematom
morrhage was d inner membgure 3) No aface was obseealed an organn of fibroblasne Postoperaogical deficits
EFERENCRohde VComplicatiand closedsubdural analysis of
active bleedinerved Histolonized hematots and capilla
ative recoverywas gradual a
ON oman had a hi
gular medicatig nutritional ma lucidum referred to ohe became proxamination rScale ratings wgth score in th
the Medical ratory examinranges with nn computed
CSDH in the midline shift (ived one righth irrigation a
motor oilndashlikespace was uncal and outer marea was irrigaough the subdusystem was plcreased the rel space An emracute hemorrfrom the frone (Figure 2B
membranectma was perfo
only observebrane of theactive bleedinerved Histolonized hematots and capilla
ative recoverywas gradual a
CES V Graf Gons of burr-
d-system draihematomas
f 376 patient
ng from the ogical examinoma with prolaries in the m
y of previous and favorable
history of hypeion treatmentsupplements for more tha
our emergencyogressively drrevealed thatwere E1M5V2he left side ex
Research Conation results no bleeding ditomography right hemisp
(Figure 1) St parietal burrand closed-sy
e fluid accumucovered after membranes oated with 50 m
dural catheter laced (Figureedness of the mergency brairrhage in the ntal region to
B) An emergtomy and remormed The ed within the e previous Cng from the ogical examinoma with prolaries in the m
y of previous and favorable
G Hassler -hole craniosinage for ch
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of Medicine V
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iew of CT rev
rietal region d
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Vol 3 No 4 2
Acute intram
Yu-Hao Chen
vealing a layer
displaying a m
quent CT scan
em drainage (
rhage in the ri
2020
membranous
Cheng-Ta Hs
red type of CS
midline shift
ns (A) Bone w
(white arrow)
ight frontal re
hemorrhage
ieh
SDH (white ar
window view
and (B) Soft
gion (white ar
rrow) in the rig
showed the b
tissue windo
rrow)
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burr hole crani
ow showed hy
123
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Fu-J
Meng
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Jen Journal o
g-Chi Lin Ju
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brane
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of Medicine V
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(white arrow)
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Vol 3 No 4 2
Acute intram
Yu-Hao Chen
o revealing ac
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2020
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cute intramem
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124
mem-
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Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh
125
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
慢性硬腦膜下出血進行鑽顱引流手術造成超急性夾膜內出
血
林孟楫 1孫瑞明 23陳昱豪 24謝政達 567
中文摘要
鑽顱併封閉系統引流手術是治療慢性硬腦膜下出血患者一種有效且常見的
神經外科手術方式術後出血可能導致神經功能缺損惡化是眾所周知但不常見
的併發症之一然而至今仍未有鑽孔併封閉系統引流造成原本慢性硬腦膜血
塊內膜和外膜間急性夾膜間出血案例在這裡我們報告一例慢性硬腦膜下出
血病患者接受鑽顱併封閉系統引流手術治療造成術後急性夾膜間出血我們在
本文中討論可能的致病機制並回顧相關文獻
關鍵字慢性硬腦膜下出血急性硬腦膜下出血出血鑽顱術引流
1國軍高雄總醫院左營分院 外科部
2崇仁醫護管理專科學校
3亞洲大學 生物科技學系
4戴德森醫療財團法人嘉義基督教醫院 外科部 神經外科
5汐止國泰綜合醫院 神經外科
6輔仁大學 醫學系
7 國防醫學院 三軍總醫院 神經外科
通訊作者謝政達 電子信箱 nogormail2000comtw
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
126
Submitted January 21 2020
Final version accepted July 08
2020
Case Report
Hamartoma of the breast A case report
Cite as Hsuan-An Chen
Cheng-Yu Lo Shih-Hung Huang
Chin-Lung Lin
Hamartoma of the breast A case
report Fu-Jen Journal of Medicine
3(5) 126-130 2020
DOI
103966181020932020091803005
Hsuan-An Chen1 Cheng-Yu Lo
3 Shih-Hung Huang
3 Chin-Lung
Lin2
1Department of Surgery Cathay General Hospital Taipei Taiwan
2Department of General Surgery Cathay General Hospital Taipei Tai-
wan
3Department of Pathology Cathay General Hospital Taipei Taiwan
Corresponding author E-mail address
lungyungmailcom (Chin-Lung Lin)
ABSTRACT
Breast hamartoma is an uncommon benign tumor rarely associated with malignancy An
excision and histological examination is necessary for the differential diagnosis We report
a case of a 49-year-old female patient presenting with a lump in the right breast Ultrasound
examination which demonstrated a 4411 cm hypoechoic lesion with lipoma Partial mas-
tectomy was arranged and the diagnosis of a hamartoma was confirmed by the histological
examination
Keywords Breast tumor Hamartoma Ultrasound
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
127
INTRODUCTION The hamartoma is a benign tumor-like lesion
that can affect various organs of the body in-
cluding lungs kidneys skin and more rarely the
breast In 1981 the hamartomas were recognized
in the WHO classification[1] They are defined
as well-demarcated mass of mammary ducts and
lobules containing varying amounts of fibrous
and adipose tissue and producing a distinctive
mammographic image
CASE REPORT A 49 year-old female had past history of left
breast mastitis with abscess status post partial
mastectomy This time she presented to our out
patient clinic for breast examination Physical
examination revealed a painless palpable mova-
ble and painless lump at upper outer quadrant of
right breast The risk of breast cancer was not
noted and the patient did not have any family
history of breast cancer The patient also denied
any trauma history before Ultrasound examina-
tion was arranged which demonstrated a 4411
cm hypoechoic lesion with lipoma at 3 oclock 2
cm from nipple of right breast and multiple hy-
poechoic nodules of various size in both breasts
and there was no suspicious axillary lymph
nodes noted (Figure1) Surgical treatment was
arranged partial mastectomy of right breast
harmartoma was successfully performed A 32 x
31 x 21 cm tumor was completely excised
Grossly examination showed a gray to yellow
and firm to fatty The diagnosis of a hamartoma
was confirmed by the histological examination
Microscopically sections of the breast lesion
show mammary hamartoma composed of ducts
lobules with interlobular fibrous tissue and adi-
pose tissue Fibrocystic change apocrine meta-
plastic ducts and scattered foci of adenosis are
noted The overall lobulocentric architecture and
the 2-cell pattern of the epithelium are preserved
columnar cell change and focal microcalcifica-
tion are present (Figure2) Based on submitted
biopsy specimen in-situ or invasive tumor cells
are not identified
DISCUSSION Hamartoma of the breast is a benign tumor like
nodule it was also known as fibroadenolipoma
lipofibroadenoma or adenolipoma based on its
predominant components It was composed of
varying amounts of glandular adipose and fi-
brous tissue[2] Hamartomas were first described
in 1971 by Arrigoni et al in a study of 10 patients
which breast tumors clinically and grossly re-
sembled fibroadenomas[3]
A higher predominance of tumors exists in fe-
males compared with males Hamartomas are
slowly-growing lesions with the diameter rang-
ing from 2 cm to 5 cm sometimes hamartomas
can reach giant diameter [4]
The clinical diagnosis of hamartoma is based on
the findings from mammography sonography
and histology examinations The hamartomas are
usually incidentally diagnosed by the women
older than 40 year-old starting mammography
screening
On physicial examination harmatomas are usu-
ally occult painless they may be as large mo-
bile soft to firm masses[5] Ultrasound showed
well capsulated mass with echogenic rim and
internal heterogeneity Mammography exam
showed well-circumscribed round to oval
masses containing fat and soft tissue densities
with a thin radiopaque pseudocapsule The
pseudocapsule results from displacement of
breast parenchyma by the tumor [56] In Pa-
thology finding microglandular adenosis is pre-
sent in fibroadipose stroma surrounded by a thin
fibrous capsule It composed of a combination of
epithelial and stromal elements usually with
normal ducts or lobules although variations of
normal tissue may also be seen Fibroadenoli-
poma myoid hamartoma and chondrolipoma are
histological variations of hamartomas depend-
ing on the proportion of normal breast tissue
elements[7]
Malignancy associated with hamartomas are
very rare[8] However it has been reported
hamartomas develop into carcinoma Malignant
transformation can occur as a result of cellular
atypia in the epithelial component of the mass[9]
Surgical removal is the curative method for
breast hamartomas[10] Diagnostic material such
as mammography ultrasonography or core nee-
dle biopsy may not give the definitive diagnosis
Therefore surgical excision and histological
examination is necessary for differential diagno-
sis[111213]
Although it is rare hamartoma can be seen along
with malignancy as it is formed from similar
components of breast tissue Therefore careful
diagnosis and appropriate management including
surgery are required
REFERENCES 1 World Health Organization (1981)
Histological typing of breast tumors In
International histological classification of
tumors 1981 2nd ed
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
128
2 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11435ndash449
2006
3 ArrigoniMG DockertyMB JuddES
The identificationand treatment of
mammary hamartoma Surg Gynecol
Obstet1971 133 577-82
4 Sanal HT Ersoz N Altinel O Unal E Can
C Giant hamartoma of the breast Breast J
2006 12 84-85
5 Feder JM de Paredes ES Hogge JP
Wilken JJ Unusual breast lesions
radiologic-pathologic correlation
Radiographics 1999 19S11ndashS26
6 Murat A Ozdemir H Yildirim H Poyraz
AK Ozercan R Hamartoma of the breast
Australas Radiol 200751 Spec NoB37ndash
9
7 Fisher CJ Hanby AM Robinson L Millis
RR Mammary hamartoma-a review of 35
cases Histopathology 1992 20 99-106
8 Choi N Ko ES Invasive ductal carcinoma
in a mammary hamartoma case report and
review of the literature Korean J Radiol
2010 Nov-Dec11(6)687-91
9 Lee EH Wylie EJ Bourke AG Bastiaan
De Boer W Invasive ductal carcinoma
arising in a breast hamartoma two case
reports and a review of the literature Clin
Radiol 2003 58 80-3
10 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11 435 ‑449
2006
11 Coyne J Hobbs FM Boggis C Harland R
Lobular carcinoma in a mammary
hamartoma J Clin Pathol 199245936ndash
937
12 G M K Tse B K B Law T K F Ma A B W
Chan Hamartoma of the breast a
clinicopathological review J Clin Pathol
200255951ndash954
13 RAAmir SSheikh BreasthamartomaA
report of 14cases of an under-recognized
and under-reported entity International
Journal of Surgery Case Reports
22(2016)1ndash4
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
129
FIGURES
Figure 1 Ultrasound shows a 4411 cm hypoechoic lesion with lipoma at 3 oclock 2 cm from nipple
of right breast
Figure 2 Photomicrograph shows mammary hamartoma composed of ducts lobules with interlobular
fibrous tissue and adipose tissue
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
130
Hamartoma of the breast A case report
乳房錯構瘤罕見個案報告
陳宣安 1羅承裕 3黃世鴻 3林錦龍 2
中文摘要
乳房錯構瘤是一種罕見之乳房良性腫瘤切除手術及病理化驗來做鑑別診斷
我們報告一位 49歲女性以可觸摸到無痛性右側乳房腫塊為臨床表徵超音波
看到一個邊緣清楚低迴音的腫塊病患接受手術切除病灶病理診斷證實為乳
房錯構瘤
關鍵字乳房腫瘤錯構瘤超音波攝影
1國泰綜合醫院外科部
2國泰綜合醫院一般外科
3國泰綜合醫院病理科
通訊作者林錦龍 電子信箱 lungyungmailcom
Fu-Jen Journal of Medicine
Mission and Goals
The Fu-Jen Journal of Medicine (FJJM) is a peer-reviewed journal which
aims to enhance research quality of staffs in the College of Medicine Fu Jen
Catholic University The journal publishes original investigations across a
wide range of medical disciplines including original research articles in basic
and clinical sciences case reports review articles brief reports and letter
to the editor FJJM is now issued by the Center of Medical Education in the
College of Medicine Fu Jen Catholic University To promote journal quality
the manuscript submitted to FJJM after August first 2015 has to be prepared
in English to meet the international standards
Issue Date
Publication Date
Institution
December 01 2003
September 30 2020
College of Medicine Fu Jen Catholic University
Honorable publisher Han-Sun Chiang
Publisher Ping-Keung Yip
Editor-in-chief Ming-Chieh Ma
Associate Editors Yu-Wen Lin
Editors
Telephone (02) 2905-3477
Address Center for Medical Education College of Medicine Fu Jen
Catholic University
No 510 Zhongzheng Rd Xinzhuang Dist New Taipei City
24205 Taiwan
Su-Jane Wang Chi-Chung Wang Chih-Ming Ho
Yih-Jing Lee Chih-Shung Wong Tze-Wah Kao
Chi-Feng Hung Rung-Fen Feng Chee-Fah Chogn
Chia-Chen Lu Zai-Ting Yeh
Dee Pei Chih-Kuang Liu
Hen-Hui Lien Chien-Hsiou Liu
Chun-Hou Liao Yi-Ju Tsai Sheng-Wen Teng
Chia-Ting Su
- 9月封面
- 9月目錄頁
- 2020九月刊排版NO1_完稿
- 2020九月刊排版NO2_完稿
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- 版權頁(SEP)
- 9月封底
-
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 108
Supplement Table 1- HFACS Content of Human Factor Analysis Classifi-
cation System [9] Tier main level sub-item nano code
Tier 1 Unsafe Acts
Perfor-
mance-Based
Errors
Unintended operation of equipment
Checklist not followed correctly
Procedure not followed correctly
Over-controlledunder-controlled aircraftvehiclesystem
Breakdown in visual scan
Rushed or delayed a necessary action
Judgment amp De-
cision-Making
Errors
Inadequate real‐time risk assessment
Failure to prioritize tasks adequately
Ignored a cautionwarning
Wrong choice of action during an operation
Violations
Performs work-around violation
Commits widespreadroutine violation
Extreme violation-lack of discipline
Tier 2 Preconditions
Environment
Physical environment
Environmental conditions affecting vision
Vibration effects vision or balance
Heatcold stress impairs performance
External force of object impeded an individualrsquos
movement
Lights of other vehiclevesselaircraft affected vision
Noise interference
Technological environment
Seat and restraint system problems
Instrumentation amp warning system issues
Visibility restrictions (not weather related)
Controls and switches are inadequate
Automated system creates unsafe situation
Workspace incompatible with operation
Personal equipment interference
Communication equipment inadequate
Physical and
Mental State
Physical problem
Substance effects (alcohol supplements medications
drugs)
Loss of consciousness (sudden or prolonged onset)
Physical illnessinjury
Fatigue
Inadequate adaptation to darkness
Dehydration
Body sizemovement limitations
Physical strength amp coordination (inappropriate for
task demands)
Nutritiondiet
State of mind
Psychological problem
Life stressors
Emotional state
Personality style
Overconfidence
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 109
Pressing
Complacency
Motivation
Motivational exhaustion (burnout)
Sensory misperception
Motion illusion-kinesthetic
Turning illusionbalance-vestibular
Visual illusion
Misperception of changing environment
Misinterpreted misread instrument
Misinterpretation of auditorysound cues
Spatial disorientation
Temporaltime distortion
Mental awareness
Not paying attention
Fixation
Task overunder saturation
Confusion
Negative habit transfer
Distraction
Geographically lost
Interferenceinterruption
Technical or procedural knowledge not retained after
training
Inaccurate expectation
Teamwork
Failure of crewteam leadership
Inadequate task delegation
Rankposition intimidation
Lack of assertiveness
Critical information not communicated
Standardproper terminology not used
Failed to effectively communicate
Taskmission planningbriefingdebriefing inadequate
Tier 3 Supervision
Supervisory Vio-
lations
Failure to enforce existing rules
Allowing unwritten policies to become standard
Directed individual to violate existing regulations
Authorized unqualified individuals for task
Planned Inappro-
priate Operations
Directed task beyond personnel capabilities
Inappropriate team composition
Selected individual with lack of current or limited experience
Performed inadequate risk assessment ‐formal
Authorized unnecessary hazard
Inadequate Su-
pervision
Supervisorycommand oversight inadequate
Improper role‐modeling
Failed to provide proper training
Failed to provide appropriate policyguidance
Personality conflict with supervisor
Lack of supervisory responses to critical information
Failed to identifycorrect risky or unsafe practices
Selected individual with lack of proficiency
Tier 4 Organizational
Influences
Resource Prob-
lems
Command and control resources are deficient
Inadequate infrastructure
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 110
Failure to remove inadequate worn-out equipment in timely
manner
Failure to provide adequate operational information resources
Fail to provide adequate funding
Personnel Selec-
tion amp Staffing
Personnel recruiting amp selection policies are inadequate
Failure to provide adequate manning staffing resources
Policy amp Process
Issues
Pace of ops-tempoworkload
Organizational programpolicy risks not adequately assessed
Provided inadequate procedural guidance or publications
Organizational (formal) training is inadequate or unavailable
Flawed doctrinephilosophy
Inadequate program management
Purchasing or providing poorly designed or unsuitable equip-
ment
ClimateCulture
Influences
Organizational culture (attitude actions) allows for unsafe
taskmission
Organizational over-confidence or under-confidence in equip-
ment
Unit missionaircraftvehicleequipment change or unit deacti-
vation
Organizational structure is unclear or inadequate
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 111
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
以 HFACS重新檢視根本原因分析案例挖掘造成醫療不良
事件之人為因素
鄭伃洵 1洪聖惠 12柯彤文 3王拔群 14
中文摘要
背景醫療不良事件(AMEs)的管理是促進病人安全的基石根本原因分析
(RCA)是探討重大病人安全不良事件問題但是由於無法解釋更廣泛的因素而受
到限制本研究使用人為因素分類與分析工具(HFACS)回溯審視醫療不良事件
以了解影響醫療不良事件的人為因素及各層面中錯誤原因之分佈或系統性問題
方法本研究回溯 2012-2016年間有做過根本原因分析之醫療不良事件以連續
性取樣方式(continuous sampling)收集 40例醫療不良事件以人為因素分類與分
析工具(HFACS)去系統性的挖掘每件案例發生錯誤之原因結果在行為層面中
分析結果主要為基礎技能錯誤(95)判斷和決策錯誤(875)其中在基礎技能
錯誤當中以未依程序作業執行(816)及未如預期設備操作(50)佔多數判斷和
決策錯誤中以現場風險評估不確實(686)及採取錯的步驟行為(686)佔多數
而在先決條件層面中以團隊合作(275)為主要因素包含溝通不良(818)及重
要訊息未以正確的方式即時傳達(727)佔多數在監督層面當中以監督不周
(929)或監督不妥當(929)為主要因素在組織政策和流程方面(50)以組織
系統的政策風險未充分評估(35)為主要因素結論本研究進一步了解醫療不
良事件在過去使用根本原因分析未探討到的人為因素反映出潛在的監督組織
行為或系統性的問題促進病人安全預防錯誤再發生
關鍵字病人安全醫療不良事件根本原因分析人為因素
1國泰醫療財團法人國泰綜合醫院 品質管理部
2國立臺灣大學健康政策與管理研究所
3振興醫療財團法人振興醫院 醫療品質管理中心
4輔仁大學醫學院
通訊作者王拔群 電子信箱 drtonyseednettw
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin 112
Submitted January 20 2020
Final version accepted April13
2020
Case Report
Juvenile Caruncular Atypical Lymphoid
Proliferation ndash A Rare Case Report
Cite as Hua-Wei Shih Yu-Chi Lin
Juvenile Caruncular Atypical
Lymphoid Proliferation ndash A Rare
Case Report Fu-Jen Journal of
Medicine 3(3) 112-119 2020
DOI
103966181020932020091803003
Hua-Wei Shih1 Yu-Chi Lin
1
1Department of Ophthalmology Shin Kong Wu Ho-Su Memorial Hos-
pital Taipei City Taiwan
Corresponding author E-mail address
yuchi067gmailcom (Yu-Chi Lin)
ABSTRACT
Lesions of the caruncle are very rare Most caruncular lesions are benign though there were still few reported malignant lesions Ocular adnexal lymphoproliferative disease (OALD) one of the differential diagnosis of caruncular lesion is seldom seen in young pa-tient In this article we report a 16-year-old boy with recurrent caruncular atypical lym-phoid proliferation We discuss the epidemiology clinical features images histomorpholo-gy and treatment between ocular adnexal lymphomas (OAL) and reactive lymphoid hyper-plasia (RLH)
Keywords caruncular lesion ocular adnexal lymphoproliferative disease ocular adnexal lymphoma
reactive lymphoid hyperplasia atypical lymphoid proliferation
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
113
INTRODUCTION Lesions of the caruncle are very rare Differen-
tial diagnosis includes nevus myeloproliferative
disorders tumors inflammation infection cysts
vascular lesions and fibrous Biopsy is essential
for diagnosis Levy J et al reported ocular ad-
nexal lymphoproliferative disease (OALD) was
relatively uncommon diagnosis among caruncu-
lar lesions [1]
OALD was seldom described in Asian popula-
tion especially for young age C-Y Cheng re-
ported age-standardized incidence of ocular
adnexal lymphomas (OAL) in Taiwan from 1979
to 1996 was below 07 per million per year and
mean age was 531 years old [2] In 2015 five
Taiwanese cases of OAL whose age ranging
from 45 to 64 were presented [3] However
there were few cases of conjunctival OAL or
RLH in Chinese pediatric patient
Here we present a case of 16-year-old boy with a
caruncular mass at his left eye with recurrence
one month after excision We describe his clini-
cal symptoms photographs pathological results
management and follow-up clinical course in
this report
CASE REPORT A 16-year-old healthy boy presented a mass
lesion at his left eye caruncle accompanied with
the symptom of tearing for one month (Figure 1)
He had no ocular pain no itchiness no blurred
vision no night sweating no fever and no body
weight loss The patient denied systemic diseas-
es and histories of surgery His bilateral best
corrected visual acuity (BCVA) were 66 and
intraocular pressure (IOP) were both within
normal range There were no remarkable find-
ings for his cornea lens fundus and physical
examination Excision was performed and the
mass was soft with fluid inside therefore con-
junctival pyogenic cyst was our initial diagnosis
However one month after the excision a pro-
truding mass recurred at the patientrsquos nasal can-
thus of left eye (Figure 2) There were some
differences compared to previous condition At
the first time the soft mass was contained in a
well-defined cyst wall which more favored py-
ogenic granulation However after short period
of recurrence solid consistency and unclear
margin were found which favored malignancy
Besides the mass partially involved beyond the
gray line of nasal part lower eyelid whereas last
time the cyst mainly extended from conjunctiva
of caruncle The second excisional biopsy was
performed Pathologic examination demonstrat-
ed abundant atypical lymphoid proliferation
(Figure 3A 3B) Immunohistochemical studies
showed that the lymphoid aggregation was
composed predominantly of CD20-positive cells
(Figure 3C) focal positive staining of CD3
(Figure 3D) CD5 CD23 CD10 and negative
staining of cyclin-D1 Unfortunately the cellular
morphology was difficult to be evaluated due to
marked crushing artifact Thus malignant lym-
phoma cannot be excluded totally
Orbital computed tomography (CT) showed a
lesion of soft tissue density at medial canthus of
left orbit without obvious nasolacrimal duct or
bony invasion (Figure 4A) Magnetic resonance
imaging (MRI) with contrast showed strong
enhancement at left medial canthus region (Fig-
ure 4B) There was no remarkable finding in the
systemic workup including complete blood
count and differential count biochemical pro-
files and 18F-fluoro-2-deoxyglucose positron
emission tomographycomputed tomography
(18F-FDG PETCT) indicating no evidence of
systemic involvement
After the second excision we preferred con-
servative management for him due to the uncer-
tainty of malignancy and to avoid side effects
from aggressive treatment No sign of recurrence
was noted after 10 months of observation The
follow-up photo was taken at three months after
the second operation (Figure 5)
DISCUSSION Ocular adnexal lymphoproliferative disease
(OALD) consists of the spectrum of lymphoid
disease affecting the tissues surrounding the eye
including ocular adnexal lymphomas (OAL) and
lymphoid hyperplasia (LH) [4] The conjunctiva
is an important location for extranodal lympho-
ma development which comprises 25 of OAL
[5]
OAL can be grouped into two categories based
on their appearance of cells under the micro-
scope low-grade and high-grade [6] Extranodal
marginal zone lymphoma of mucosa-associated
lymphoid tissue (EMZLMALT) is the most
common subtype of OAL followed by follicular
lymphoma [7-9] Both of the above are
low-grade lymphomas
LH can be further divided by histopathology into
reactive lymphoid hyperplasia (RLH) and atypi-
cal lymphoid hyperplasia (ALH) RLH has to-
tally benign morphology and immunophenotype
whereas ALH has borderline lesions between
RLH and lymphoma [10] OAL and LH are
mostly seen in patients with age between 50-70
years old There are rare cases in pediatric group
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
114
[71011] In the C-Y Chengrsquos statistical report of
OAL in Taiwan only 8 patients were younger
than 15 years old among the 101 cases of ocular
lymphoma [2] According to an US study inci-
dence rates of OAL were analyzed in different
age groups the group of age over 50 had the
highest incidence rate of 574 per million per-
son-years while the 0-19 age group had the
lowest incidence rate of 009 per million per-
son-years [12] The incidence of LH was even
less than OAL [13]
Patients with OALD may be asymptomatic or
with symptoms of proptosis eyelid swelling a
palpable painless mass or conjunctival salmon
patch Diplopia visual loss pain or inflamma-
tion occurred less frequently implying more
aggressive features [714]
Orbital LH is not distinguishable from low-grade
lymphoma radiologically They both typically
present a round or lobulated mass that diffusely
moderately enhances with contrast and usually
shows homogenous hypointense or isointense to
muscle barely invasion to bone or nervous sys-
tem [10] Atypical appearances including inho-
mogeneous calcification or bony changes may
be seen in high-grade lymphoma case reports
such as ocular adnexal diffuse large B-cell lym-
phoma (DLBCL) which is one of the more ag-
gressive type of OAL [7] Whole body PET is
used for not only the evaluation of systemic
involvement but also the standard for staging
lymphoma Our patientrsquos image studies revealed
neither obvious local invasion nor systemic ma-
lignancy indicating high-grade lymphoma was
less likely Low-grade lymphoma and benign
reactive lymphoid hyperplasia were still under
consideration
Histomorphology analysis and immunohisto-
chemistry (IHC) are essential for diagnosis
Flow cytometry and polymerase chain reaction
(PCR) technique are also applied to help differ-
entiate from RLH and OAL [1016] Our case
had immunohistochemical profile of positivity
for CD20 predominantly positivity focally for
CD3 CD5 CD10 CD23 and negativity for cy-
clin-D1 BCL-6 staining was not performed in
our casersquos biopsy Thus according to the IHC
report RLH ALH and follicular lymphoma are
probable diagnosis of our patient
Radiation therapy is the standard treatment for
low-grade OAL that is classified as T1N0M0 or
T2N0M0 according to the AJCC criteria [15]
İncesoy-Ouml zdemir S et al reported a 10-year-old
boy diagnosed of MALT lymphoma who was
treated with local radiotherapy (36 Gy) and
there were no local or systemic recurrences dur-
ing his nearly four-year follow-up [17] Another
case report represented a 21-year-old man of
conjunctival follicular lymphoma treated with
surgical excision only showing no evidence of
recurrence after 8 months follow-up [18] Other
treatment options for pediatric and juvenile OAL
were performed in some case reports including
intravenous rituximab intralesional interfer-
on-α-2b topical interferon a6 systemic doxycy-
cline surgical excision and postoperative local
cryotherapy [15]
Treatment for young conjunctival RLH was less
discussed in the past In a case series article
three children (9 13 14 years old respectively)
of RLH received surgical resection without fur-
ther postoperative management and no signs of
recurrence were noted during follow-up [19]
Short-term topical and oral corticosteroids after
surgical excision were prescribed in two pediat-
ric RLH patients for their small residual mass
However poor response in both cases was nota-
ble [20]
Our patient declined to receive radiotherapy or
any further postoperative treatment mainly due
to his concerning of possible side effects (such
as dry eye and cataract)
CONCLUSION We present a rare case of caruncle mass in this
report OALD is one of the relatively uncommon
diagnosis among caruncular lesions OALD
includes benign RLH and malignant OAL
which are both mainly seen in elderly patients
even rarer in pediatric or juvenile group
The standard treatment for low-grade OAL and
RLH in young patents are still debatable How-
ever long-term follow-up is suggested for both
OAL and RLH patients Though RLH has a be-
nign and self-limited course risk of malignant
transformation is possible
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the caruncle a description of 42 cases and
a review of the literature Eye
200923(5)1004-1018
2 C-Y Cheng and W-M Hsu Incidence of
eye cancer in Taiwan an 18-year review
Eye 200418152-158
3 Chui-Lien Tsen Muh-Chiou Lin
Youn-Shen Bee et al Ocular adnexal
lymphoma Five case reports and a
literature review Taiwan Journal of
Ophthalmology 20155(2)99-102
4 Liesegang TJ Ocular adnexal
lymphoproliferative lesions Mayo Clin
Proc 199368(10)1003-1010
5 Kirkegaard MM Coupland SE Prause JU
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
115
et al Malignant lymphoma of the
conjunctiva Surv Ophthalmol
201560(5)444-458
6 Stacy RC Jakobiec FA Schoenfield L et
al Unifocal and multifocal reactive
lymphoid hyperplasia vs follicular
lymphoma of the ocular adnexa Am J
Ophthalmol 2010150(3)412-426
7 Sullivan TJ Ocular Adnexal
Lymphoproliferative Disease In Guthoff
RF Katowitz JA eds Oculoplastics and
Orbit Berlin Heidelberg Springer
20101-19
8 White Valerie A Understanding and
Classification of Ocular Lymphomas
Ocular Oncology and Pathology
20195379-386
9 Stefanovic A Lossos IS Extranodal
marginal zone lymphoma of the ocular
adnexa Blood 2009114(3)501-510
10 Andrew NH Coupland SE Pirbhai A et al
Lymphoid hyperplasia of the orbit and
ocular adnexa A clinical pathologic review
Surv Ophthalmol 201661(6)778-790
11 Ferry JA1 Fung CY Zukerberg L et al
Lymphoma of the ocular adnexa A study
of 353 cases Am J Surg Pathol
200731(2)170-184
12 WM Hassan MS Bakry HM Hassan et al
Incidence of orbital conjunctival and
lacrimal gland malignant tumors in USA
from Surveillance Epidemiology and End
Results 1973-2009 Int J Ophthalmol
20169(12)1808-1813
13 Ajay A Rao John H Naheedy James Y-Y
Chen et al A Clinical Update and
Radiologic Review of Pediatric Orbital
and Ocular Tumors Journal of Oncology
2013(9)975908
14 Sullivan TJ Whitehead K Williamson R
et al Lymphoproliferative disease of the
ocular adnexa a clinical and pathologic
study with statistical analysis of 69
patients Ophthal Plast Reconstr Surg
200521177-188
15 Tanenbaum RE Galor A Dubovy SR et al
Classification diagnosis and management
of conjunctival lymphoma Eye Vis (Lond)
2019622
16 Olga Klavdianou Georgios Kondylis
Vasileios Georgopoulos et al Bilateral
benign reactive lymphoid hyperplasia of
the conjunctiva a case treated with oral
doxycycline and review of the literature
Eye Vis (Lond) 2019626
17 İncesoy-Ouml zdemir S Yuumlksek N Bozkurt C
et al A rare type of cancer in children
extranodal marginal zone B-cell (MALT)
lymphoma of the ocular adnexa Turk J
Pediatr 201456(3)295-298
18 Lynn J Poole Perry Frederick A Jakobiec
Peter A D Rubin Conjunctival Pediatric
Follicular Lymphoma Arch Ophthalmol
2012130(7)941-943
19 Abdullah Al-Mujaini Upender Wali
Anuradha Ganesh1 et al Ocular Adnexal
Reactive Lymphoid Hyperplasia in
Children Middle East Afr J Ophthalmol
201219(4)406-409
20 McLeod SD Edward DP Benign
lymphoid hyperplasia of the conjunctiva in
children Arch Ophthalmol
1999117(6)832-835
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
116
FIGURES
Figure 1 Slit lamp image of a mass lesion at the patientrsquos left eye caruncle for one month
Figure 2 One month after the first excision a protruding mass recurred at the patientrsquos nasal canthus
of left eye It partially involved beyond the gray line of nasal part lower eyelid
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
117
Figure 3 Histomorphology analysis and immunohistochemistry study of the caruncular lesion Abun-
dant atypical lymphoid proliferation presented in low-power photomicrograph (A) and
high-power photomicrograph (B) under hematoxylin-eosin staining The lymphoid aggrega-
tion was composed predominantly of CD20-positive cells (C) and focal positive staining of
CD3 (D)
Figure 4 Non-contrast orbital computed tomography showed a lesion of soft tissue density at medial
canthus of left orbit without obvious nasolacrimal duct or bony invasion (A) Magnetic reso-
nance imaging with contrast showed strong enhancement at left medial canthus region (B)
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
118
Figure 5 The follow-up photo were taken at three months after the second excision showing no signs
of recurrence
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
119
Juvenile Caruncular Atypical Lymphoid Proliferation ndash A Rare Case Report
罕見病例報告mdash青少年之淚阜非典型淋巴增生
施驊瑋 1林友祺 1
中文摘要
淚阜病灶相當罕見大部分為良性病灶眼睛及附屬結構淋巴增生疾病為其
鑑別診斷之一非常少見於年輕人或兒童我們報告一位 16歲的健康男性因
左眼淚阜無痛性腫塊接受切除手術卻於術後一個月復發執行第二次切除手術
後門診追蹤十個月未再復發此案例表現了部分良性與部分惡性腫瘤的特徵
我們針對反應性淋巴增生眼睛及附屬結構淋巴癌兩個疾病做討論及文獻回顧
關鍵字淚阜病灶眼睛及附屬結構淋巴增生疾病眼睛及附屬結構淋巴癌反
應性淋巴增生非典型淋巴增生
1 新光吳火獅紀念醫院眼科
通訊作者林友祺 電子信箱 yuchi067gmailcom
Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh 120
Submitted March 26 2020
Final version accepted April 16
2020
Case Report
Hyperacute intramembranous hemor-
rhage after burr hole craniostomy for
chronic subdural hematoma
Cite as Meng-Chi Lin Jui-Ming
Sun Yu-Hao Chen Cheng-Ta
Hsieh
Hyperacute intramembranous
hemorrhage after burr hole crani-
ostomy for chronic subdural he-
matoma Fu-Jen Journal of Medi-
cine 3(4) 120-125 2020
DOI
103966181020932020091803004
Meng-Chi Lin1 Jui-Ming Sun23 Yu-Hao Chen24 Cheng-Ta
Hsieh567
1Department of Surgery Zuoying Branch Kaohsiung Armed Forces
General Hospital Kaohsiung 813 Taiwan 2Section of Neurosurgery Department of Surgery Chia-Yi Christian
Hospital Chia-Yi City 600 Taiwan 3Department of Biotechnology Asia University Taichung City 41354
Taiwan 4Chung-Jen Junior College of Nursing Health Sciences and Manage-
ment Chia-Yi Country 62241 Taiwan 5Division of Neurosurgery Department of Surgery Sijhih Cathay Gen-
eral Hospital New Taipei City 22174 Taiwan 6Department of Medicine School of Medicine Fu Jen Catholic Univer-
sity New Taipei City 24205 Taiwan 7Department of Neurological Surgery Tri-Service General Hospital
National Defense Medical Center Taipei 114 Taiwan
Corresponding author E-mail address
nogormail2000comtw (Cheng-Ta Hsieh)
ABSTRACT
Burr hole craniostomy with closed-system drainage is an effective and common neurosurgical procedure to manage chronic subdural hematoma Postoperative hem-orrhage a well-known but infrequent complication may result in increased neurolog-ical deficits However hyperacute intramembranous hemorrhage within the inner and outer membrane of hematoma after burr hole craniostomy with irrigation and closed-system drainage has not been described previously Herein we report a case of postoperative spontaneous hyperacute intramembranous hemorrhage after burr hole craniostomy with closed-system drainage to manage a chronic subdural hematoma we subsequently discuss the possible pathophysiological mechanisms and review the relevant literature
Keywords Chronic subdural hematoma acute subdural hematoma bleeding burr hole craniostomy
drainage
Fu-J
Meng
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of Medicine V
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(Figure 2B)membranecto
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Vol 3 No 4 2
Acute intram
Yu-Hao Chen
CSDH) one ofuiring neurosugressive collechematomas in
outer and ievidence suggwith or wite and widely ut and that it ] Recurrence r this surgerywever the hyng after burr ely been discucase of a pa
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gure 3) No aface was obseealed an organn of fibroblasne Postoperaogical deficits
ISCUSSIO61-year-old won without regd been takingning Ganodermrs She was tment when shurological exasgow Coma S
muscle strengs was 45 on
ale Her laborh the normal rnoted Brain
n revealed Ch a marked m
ently she receniostomy withinage ring surgery mthe subdural sn of the duramatoma The arile saline throsed drainage swever this inm the subduraealed a hyperdural space fniostomy siteniotomy withthe hematom
morrhage was d inner membgure 3) No aface was obseealed an organn of fibroblasne Postoperaogical deficits
EFERENCRohde VComplicatiand closedsubdural analysis of
active bleedinerved Histolonized hematots and capilla
ative recoverywas gradual a
ON oman had a hi
gular medicatig nutritional ma lucidum referred to ohe became proxamination rScale ratings wgth score in th
the Medical ratory examinranges with nn computed
CSDH in the midline shift (ived one righth irrigation a
motor oilndashlikespace was uncal and outer marea was irrigaough the subdusystem was plcreased the rel space An emracute hemorrfrom the frone (Figure 2B
membranectma was perfo
only observebrane of theactive bleedinerved Histolonized hematots and capilla
ative recoverywas gradual a
CES V Graf Gons of burr-
d-system draihematomas
f 376 patient
ng from the ogical examinoma with prolaries in the m
y of previous and favorable
history of hypeion treatmentsupplements for more tha
our emergencyogressively drrevealed thatwere E1M5V2he left side ex
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(Figure 1) St parietal burrand closed-sy
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dural catheter laced (Figureedness of the mergency brairrhage in the ntal region to
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y of previous and favorable
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Vol 3 No 4 2
Acute intram
Yu-Hao Chen
vealing a layer
displaying a m
quent CT scan
em drainage (
rhage in the ri
2020
membranous
Cheng-Ta Hs
red type of CS
midline shift
ns (A) Bone w
(white arrow)
ight frontal re
hemorrhage
ieh
SDH (white ar
window view
and (B) Soft
gion (white ar
rrow) in the rig
showed the b
tissue windo
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ow showed hy
123
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Fu-J
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Jen Journal o
g-Chi Lin Ju
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of Medicine V
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(white arrow)
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Vol 3 No 4 2
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Yu-Hao Chen
o revealing ac
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the previous b
2020
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cute intramem
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124
mem-
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Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh
125
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
慢性硬腦膜下出血進行鑽顱引流手術造成超急性夾膜內出
血
林孟楫 1孫瑞明 23陳昱豪 24謝政達 567
中文摘要
鑽顱併封閉系統引流手術是治療慢性硬腦膜下出血患者一種有效且常見的
神經外科手術方式術後出血可能導致神經功能缺損惡化是眾所周知但不常見
的併發症之一然而至今仍未有鑽孔併封閉系統引流造成原本慢性硬腦膜血
塊內膜和外膜間急性夾膜間出血案例在這裡我們報告一例慢性硬腦膜下出
血病患者接受鑽顱併封閉系統引流手術治療造成術後急性夾膜間出血我們在
本文中討論可能的致病機制並回顧相關文獻
關鍵字慢性硬腦膜下出血急性硬腦膜下出血出血鑽顱術引流
1國軍高雄總醫院左營分院 外科部
2崇仁醫護管理專科學校
3亞洲大學 生物科技學系
4戴德森醫療財團法人嘉義基督教醫院 外科部 神經外科
5汐止國泰綜合醫院 神經外科
6輔仁大學 醫學系
7 國防醫學院 三軍總醫院 神經外科
通訊作者謝政達 電子信箱 nogormail2000comtw
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
126
Submitted January 21 2020
Final version accepted July 08
2020
Case Report
Hamartoma of the breast A case report
Cite as Hsuan-An Chen
Cheng-Yu Lo Shih-Hung Huang
Chin-Lung Lin
Hamartoma of the breast A case
report Fu-Jen Journal of Medicine
3(5) 126-130 2020
DOI
103966181020932020091803005
Hsuan-An Chen1 Cheng-Yu Lo
3 Shih-Hung Huang
3 Chin-Lung
Lin2
1Department of Surgery Cathay General Hospital Taipei Taiwan
2Department of General Surgery Cathay General Hospital Taipei Tai-
wan
3Department of Pathology Cathay General Hospital Taipei Taiwan
Corresponding author E-mail address
lungyungmailcom (Chin-Lung Lin)
ABSTRACT
Breast hamartoma is an uncommon benign tumor rarely associated with malignancy An
excision and histological examination is necessary for the differential diagnosis We report
a case of a 49-year-old female patient presenting with a lump in the right breast Ultrasound
examination which demonstrated a 4411 cm hypoechoic lesion with lipoma Partial mas-
tectomy was arranged and the diagnosis of a hamartoma was confirmed by the histological
examination
Keywords Breast tumor Hamartoma Ultrasound
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
127
INTRODUCTION The hamartoma is a benign tumor-like lesion
that can affect various organs of the body in-
cluding lungs kidneys skin and more rarely the
breast In 1981 the hamartomas were recognized
in the WHO classification[1] They are defined
as well-demarcated mass of mammary ducts and
lobules containing varying amounts of fibrous
and adipose tissue and producing a distinctive
mammographic image
CASE REPORT A 49 year-old female had past history of left
breast mastitis with abscess status post partial
mastectomy This time she presented to our out
patient clinic for breast examination Physical
examination revealed a painless palpable mova-
ble and painless lump at upper outer quadrant of
right breast The risk of breast cancer was not
noted and the patient did not have any family
history of breast cancer The patient also denied
any trauma history before Ultrasound examina-
tion was arranged which demonstrated a 4411
cm hypoechoic lesion with lipoma at 3 oclock 2
cm from nipple of right breast and multiple hy-
poechoic nodules of various size in both breasts
and there was no suspicious axillary lymph
nodes noted (Figure1) Surgical treatment was
arranged partial mastectomy of right breast
harmartoma was successfully performed A 32 x
31 x 21 cm tumor was completely excised
Grossly examination showed a gray to yellow
and firm to fatty The diagnosis of a hamartoma
was confirmed by the histological examination
Microscopically sections of the breast lesion
show mammary hamartoma composed of ducts
lobules with interlobular fibrous tissue and adi-
pose tissue Fibrocystic change apocrine meta-
plastic ducts and scattered foci of adenosis are
noted The overall lobulocentric architecture and
the 2-cell pattern of the epithelium are preserved
columnar cell change and focal microcalcifica-
tion are present (Figure2) Based on submitted
biopsy specimen in-situ or invasive tumor cells
are not identified
DISCUSSION Hamartoma of the breast is a benign tumor like
nodule it was also known as fibroadenolipoma
lipofibroadenoma or adenolipoma based on its
predominant components It was composed of
varying amounts of glandular adipose and fi-
brous tissue[2] Hamartomas were first described
in 1971 by Arrigoni et al in a study of 10 patients
which breast tumors clinically and grossly re-
sembled fibroadenomas[3]
A higher predominance of tumors exists in fe-
males compared with males Hamartomas are
slowly-growing lesions with the diameter rang-
ing from 2 cm to 5 cm sometimes hamartomas
can reach giant diameter [4]
The clinical diagnosis of hamartoma is based on
the findings from mammography sonography
and histology examinations The hamartomas are
usually incidentally diagnosed by the women
older than 40 year-old starting mammography
screening
On physicial examination harmatomas are usu-
ally occult painless they may be as large mo-
bile soft to firm masses[5] Ultrasound showed
well capsulated mass with echogenic rim and
internal heterogeneity Mammography exam
showed well-circumscribed round to oval
masses containing fat and soft tissue densities
with a thin radiopaque pseudocapsule The
pseudocapsule results from displacement of
breast parenchyma by the tumor [56] In Pa-
thology finding microglandular adenosis is pre-
sent in fibroadipose stroma surrounded by a thin
fibrous capsule It composed of a combination of
epithelial and stromal elements usually with
normal ducts or lobules although variations of
normal tissue may also be seen Fibroadenoli-
poma myoid hamartoma and chondrolipoma are
histological variations of hamartomas depend-
ing on the proportion of normal breast tissue
elements[7]
Malignancy associated with hamartomas are
very rare[8] However it has been reported
hamartomas develop into carcinoma Malignant
transformation can occur as a result of cellular
atypia in the epithelial component of the mass[9]
Surgical removal is the curative method for
breast hamartomas[10] Diagnostic material such
as mammography ultrasonography or core nee-
dle biopsy may not give the definitive diagnosis
Therefore surgical excision and histological
examination is necessary for differential diagno-
sis[111213]
Although it is rare hamartoma can be seen along
with malignancy as it is formed from similar
components of breast tissue Therefore careful
diagnosis and appropriate management including
surgery are required
REFERENCES 1 World Health Organization (1981)
Histological typing of breast tumors In
International histological classification of
tumors 1981 2nd ed
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
128
2 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11435ndash449
2006
3 ArrigoniMG DockertyMB JuddES
The identificationand treatment of
mammary hamartoma Surg Gynecol
Obstet1971 133 577-82
4 Sanal HT Ersoz N Altinel O Unal E Can
C Giant hamartoma of the breast Breast J
2006 12 84-85
5 Feder JM de Paredes ES Hogge JP
Wilken JJ Unusual breast lesions
radiologic-pathologic correlation
Radiographics 1999 19S11ndashS26
6 Murat A Ozdemir H Yildirim H Poyraz
AK Ozercan R Hamartoma of the breast
Australas Radiol 200751 Spec NoB37ndash
9
7 Fisher CJ Hanby AM Robinson L Millis
RR Mammary hamartoma-a review of 35
cases Histopathology 1992 20 99-106
8 Choi N Ko ES Invasive ductal carcinoma
in a mammary hamartoma case report and
review of the literature Korean J Radiol
2010 Nov-Dec11(6)687-91
9 Lee EH Wylie EJ Bourke AG Bastiaan
De Boer W Invasive ductal carcinoma
arising in a breast hamartoma two case
reports and a review of the literature Clin
Radiol 2003 58 80-3
10 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11 435 ‑449
2006
11 Coyne J Hobbs FM Boggis C Harland R
Lobular carcinoma in a mammary
hamartoma J Clin Pathol 199245936ndash
937
12 G M K Tse B K B Law T K F Ma A B W
Chan Hamartoma of the breast a
clinicopathological review J Clin Pathol
200255951ndash954
13 RAAmir SSheikh BreasthamartomaA
report of 14cases of an under-recognized
and under-reported entity International
Journal of Surgery Case Reports
22(2016)1ndash4
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
129
FIGURES
Figure 1 Ultrasound shows a 4411 cm hypoechoic lesion with lipoma at 3 oclock 2 cm from nipple
of right breast
Figure 2 Photomicrograph shows mammary hamartoma composed of ducts lobules with interlobular
fibrous tissue and adipose tissue
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
130
Hamartoma of the breast A case report
乳房錯構瘤罕見個案報告
陳宣安 1羅承裕 3黃世鴻 3林錦龍 2
中文摘要
乳房錯構瘤是一種罕見之乳房良性腫瘤切除手術及病理化驗來做鑑別診斷
我們報告一位 49歲女性以可觸摸到無痛性右側乳房腫塊為臨床表徵超音波
看到一個邊緣清楚低迴音的腫塊病患接受手術切除病灶病理診斷證實為乳
房錯構瘤
關鍵字乳房腫瘤錯構瘤超音波攝影
1國泰綜合醫院外科部
2國泰綜合醫院一般外科
3國泰綜合醫院病理科
通訊作者林錦龍 電子信箱 lungyungmailcom
Fu-Jen Journal of Medicine
Mission and Goals
The Fu-Jen Journal of Medicine (FJJM) is a peer-reviewed journal which
aims to enhance research quality of staffs in the College of Medicine Fu Jen
Catholic University The journal publishes original investigations across a
wide range of medical disciplines including original research articles in basic
and clinical sciences case reports review articles brief reports and letter
to the editor FJJM is now issued by the Center of Medical Education in the
College of Medicine Fu Jen Catholic University To promote journal quality
the manuscript submitted to FJJM after August first 2015 has to be prepared
in English to meet the international standards
Issue Date
Publication Date
Institution
December 01 2003
September 30 2020
College of Medicine Fu Jen Catholic University
Honorable publisher Han-Sun Chiang
Publisher Ping-Keung Yip
Editor-in-chief Ming-Chieh Ma
Associate Editors Yu-Wen Lin
Editors
Telephone (02) 2905-3477
Address Center for Medical Education College of Medicine Fu Jen
Catholic University
No 510 Zhongzheng Rd Xinzhuang Dist New Taipei City
24205 Taiwan
Su-Jane Wang Chi-Chung Wang Chih-Ming Ho
Yih-Jing Lee Chih-Shung Wong Tze-Wah Kao
Chi-Feng Hung Rung-Fen Feng Chee-Fah Chogn
Chia-Chen Lu Zai-Ting Yeh
Dee Pei Chih-Kuang Liu
Hen-Hui Lien Chien-Hsiou Liu
Chun-Hou Liao Yi-Ju Tsai Sheng-Wen Teng
Chia-Ting Su
- 9月封面
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- 2020九月刊排版NO1_完稿
- 2020九月刊排版NO2_完稿
- 2020九月刊排版NO3_完稿
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- 2020九月刊排版NO5_完稿
- 版權頁(SEP)
- 9月封底
-
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 109
Pressing
Complacency
Motivation
Motivational exhaustion (burnout)
Sensory misperception
Motion illusion-kinesthetic
Turning illusionbalance-vestibular
Visual illusion
Misperception of changing environment
Misinterpreted misread instrument
Misinterpretation of auditorysound cues
Spatial disorientation
Temporaltime distortion
Mental awareness
Not paying attention
Fixation
Task overunder saturation
Confusion
Negative habit transfer
Distraction
Geographically lost
Interferenceinterruption
Technical or procedural knowledge not retained after
training
Inaccurate expectation
Teamwork
Failure of crewteam leadership
Inadequate task delegation
Rankposition intimidation
Lack of assertiveness
Critical information not communicated
Standardproper terminology not used
Failed to effectively communicate
Taskmission planningbriefingdebriefing inadequate
Tier 3 Supervision
Supervisory Vio-
lations
Failure to enforce existing rules
Allowing unwritten policies to become standard
Directed individual to violate existing regulations
Authorized unqualified individuals for task
Planned Inappro-
priate Operations
Directed task beyond personnel capabilities
Inappropriate team composition
Selected individual with lack of current or limited experience
Performed inadequate risk assessment ‐formal
Authorized unnecessary hazard
Inadequate Su-
pervision
Supervisorycommand oversight inadequate
Improper role‐modeling
Failed to provide proper training
Failed to provide appropriate policyguidance
Personality conflict with supervisor
Lack of supervisory responses to critical information
Failed to identifycorrect risky or unsafe practices
Selected individual with lack of proficiency
Tier 4 Organizational
Influences
Resource Prob-
lems
Command and control resources are deficient
Inadequate infrastructure
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 110
Failure to remove inadequate worn-out equipment in timely
manner
Failure to provide adequate operational information resources
Fail to provide adequate funding
Personnel Selec-
tion amp Staffing
Personnel recruiting amp selection policies are inadequate
Failure to provide adequate manning staffing resources
Policy amp Process
Issues
Pace of ops-tempoworkload
Organizational programpolicy risks not adequately assessed
Provided inadequate procedural guidance or publications
Organizational (formal) training is inadequate or unavailable
Flawed doctrinephilosophy
Inadequate program management
Purchasing or providing poorly designed or unsuitable equip-
ment
ClimateCulture
Influences
Organizational culture (attitude actions) allows for unsafe
taskmission
Organizational over-confidence or under-confidence in equip-
ment
Unit missionaircraftvehicleequipment change or unit deacti-
vation
Organizational structure is unclear or inadequate
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 111
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
以 HFACS重新檢視根本原因分析案例挖掘造成醫療不良
事件之人為因素
鄭伃洵 1洪聖惠 12柯彤文 3王拔群 14
中文摘要
背景醫療不良事件(AMEs)的管理是促進病人安全的基石根本原因分析
(RCA)是探討重大病人安全不良事件問題但是由於無法解釋更廣泛的因素而受
到限制本研究使用人為因素分類與分析工具(HFACS)回溯審視醫療不良事件
以了解影響醫療不良事件的人為因素及各層面中錯誤原因之分佈或系統性問題
方法本研究回溯 2012-2016年間有做過根本原因分析之醫療不良事件以連續
性取樣方式(continuous sampling)收集 40例醫療不良事件以人為因素分類與分
析工具(HFACS)去系統性的挖掘每件案例發生錯誤之原因結果在行為層面中
分析結果主要為基礎技能錯誤(95)判斷和決策錯誤(875)其中在基礎技能
錯誤當中以未依程序作業執行(816)及未如預期設備操作(50)佔多數判斷和
決策錯誤中以現場風險評估不確實(686)及採取錯的步驟行為(686)佔多數
而在先決條件層面中以團隊合作(275)為主要因素包含溝通不良(818)及重
要訊息未以正確的方式即時傳達(727)佔多數在監督層面當中以監督不周
(929)或監督不妥當(929)為主要因素在組織政策和流程方面(50)以組織
系統的政策風險未充分評估(35)為主要因素結論本研究進一步了解醫療不
良事件在過去使用根本原因分析未探討到的人為因素反映出潛在的監督組織
行為或系統性的問題促進病人安全預防錯誤再發生
關鍵字病人安全醫療不良事件根本原因分析人為因素
1國泰醫療財團法人國泰綜合醫院 品質管理部
2國立臺灣大學健康政策與管理研究所
3振興醫療財團法人振興醫院 醫療品質管理中心
4輔仁大學醫學院
通訊作者王拔群 電子信箱 drtonyseednettw
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin 112
Submitted January 20 2020
Final version accepted April13
2020
Case Report
Juvenile Caruncular Atypical Lymphoid
Proliferation ndash A Rare Case Report
Cite as Hua-Wei Shih Yu-Chi Lin
Juvenile Caruncular Atypical
Lymphoid Proliferation ndash A Rare
Case Report Fu-Jen Journal of
Medicine 3(3) 112-119 2020
DOI
103966181020932020091803003
Hua-Wei Shih1 Yu-Chi Lin
1
1Department of Ophthalmology Shin Kong Wu Ho-Su Memorial Hos-
pital Taipei City Taiwan
Corresponding author E-mail address
yuchi067gmailcom (Yu-Chi Lin)
ABSTRACT
Lesions of the caruncle are very rare Most caruncular lesions are benign though there were still few reported malignant lesions Ocular adnexal lymphoproliferative disease (OALD) one of the differential diagnosis of caruncular lesion is seldom seen in young pa-tient In this article we report a 16-year-old boy with recurrent caruncular atypical lym-phoid proliferation We discuss the epidemiology clinical features images histomorpholo-gy and treatment between ocular adnexal lymphomas (OAL) and reactive lymphoid hyper-plasia (RLH)
Keywords caruncular lesion ocular adnexal lymphoproliferative disease ocular adnexal lymphoma
reactive lymphoid hyperplasia atypical lymphoid proliferation
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
113
INTRODUCTION Lesions of the caruncle are very rare Differen-
tial diagnosis includes nevus myeloproliferative
disorders tumors inflammation infection cysts
vascular lesions and fibrous Biopsy is essential
for diagnosis Levy J et al reported ocular ad-
nexal lymphoproliferative disease (OALD) was
relatively uncommon diagnosis among caruncu-
lar lesions [1]
OALD was seldom described in Asian popula-
tion especially for young age C-Y Cheng re-
ported age-standardized incidence of ocular
adnexal lymphomas (OAL) in Taiwan from 1979
to 1996 was below 07 per million per year and
mean age was 531 years old [2] In 2015 five
Taiwanese cases of OAL whose age ranging
from 45 to 64 were presented [3] However
there were few cases of conjunctival OAL or
RLH in Chinese pediatric patient
Here we present a case of 16-year-old boy with a
caruncular mass at his left eye with recurrence
one month after excision We describe his clini-
cal symptoms photographs pathological results
management and follow-up clinical course in
this report
CASE REPORT A 16-year-old healthy boy presented a mass
lesion at his left eye caruncle accompanied with
the symptom of tearing for one month (Figure 1)
He had no ocular pain no itchiness no blurred
vision no night sweating no fever and no body
weight loss The patient denied systemic diseas-
es and histories of surgery His bilateral best
corrected visual acuity (BCVA) were 66 and
intraocular pressure (IOP) were both within
normal range There were no remarkable find-
ings for his cornea lens fundus and physical
examination Excision was performed and the
mass was soft with fluid inside therefore con-
junctival pyogenic cyst was our initial diagnosis
However one month after the excision a pro-
truding mass recurred at the patientrsquos nasal can-
thus of left eye (Figure 2) There were some
differences compared to previous condition At
the first time the soft mass was contained in a
well-defined cyst wall which more favored py-
ogenic granulation However after short period
of recurrence solid consistency and unclear
margin were found which favored malignancy
Besides the mass partially involved beyond the
gray line of nasal part lower eyelid whereas last
time the cyst mainly extended from conjunctiva
of caruncle The second excisional biopsy was
performed Pathologic examination demonstrat-
ed abundant atypical lymphoid proliferation
(Figure 3A 3B) Immunohistochemical studies
showed that the lymphoid aggregation was
composed predominantly of CD20-positive cells
(Figure 3C) focal positive staining of CD3
(Figure 3D) CD5 CD23 CD10 and negative
staining of cyclin-D1 Unfortunately the cellular
morphology was difficult to be evaluated due to
marked crushing artifact Thus malignant lym-
phoma cannot be excluded totally
Orbital computed tomography (CT) showed a
lesion of soft tissue density at medial canthus of
left orbit without obvious nasolacrimal duct or
bony invasion (Figure 4A) Magnetic resonance
imaging (MRI) with contrast showed strong
enhancement at left medial canthus region (Fig-
ure 4B) There was no remarkable finding in the
systemic workup including complete blood
count and differential count biochemical pro-
files and 18F-fluoro-2-deoxyglucose positron
emission tomographycomputed tomography
(18F-FDG PETCT) indicating no evidence of
systemic involvement
After the second excision we preferred con-
servative management for him due to the uncer-
tainty of malignancy and to avoid side effects
from aggressive treatment No sign of recurrence
was noted after 10 months of observation The
follow-up photo was taken at three months after
the second operation (Figure 5)
DISCUSSION Ocular adnexal lymphoproliferative disease
(OALD) consists of the spectrum of lymphoid
disease affecting the tissues surrounding the eye
including ocular adnexal lymphomas (OAL) and
lymphoid hyperplasia (LH) [4] The conjunctiva
is an important location for extranodal lympho-
ma development which comprises 25 of OAL
[5]
OAL can be grouped into two categories based
on their appearance of cells under the micro-
scope low-grade and high-grade [6] Extranodal
marginal zone lymphoma of mucosa-associated
lymphoid tissue (EMZLMALT) is the most
common subtype of OAL followed by follicular
lymphoma [7-9] Both of the above are
low-grade lymphomas
LH can be further divided by histopathology into
reactive lymphoid hyperplasia (RLH) and atypi-
cal lymphoid hyperplasia (ALH) RLH has to-
tally benign morphology and immunophenotype
whereas ALH has borderline lesions between
RLH and lymphoma [10] OAL and LH are
mostly seen in patients with age between 50-70
years old There are rare cases in pediatric group
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
114
[71011] In the C-Y Chengrsquos statistical report of
OAL in Taiwan only 8 patients were younger
than 15 years old among the 101 cases of ocular
lymphoma [2] According to an US study inci-
dence rates of OAL were analyzed in different
age groups the group of age over 50 had the
highest incidence rate of 574 per million per-
son-years while the 0-19 age group had the
lowest incidence rate of 009 per million per-
son-years [12] The incidence of LH was even
less than OAL [13]
Patients with OALD may be asymptomatic or
with symptoms of proptosis eyelid swelling a
palpable painless mass or conjunctival salmon
patch Diplopia visual loss pain or inflamma-
tion occurred less frequently implying more
aggressive features [714]
Orbital LH is not distinguishable from low-grade
lymphoma radiologically They both typically
present a round or lobulated mass that diffusely
moderately enhances with contrast and usually
shows homogenous hypointense or isointense to
muscle barely invasion to bone or nervous sys-
tem [10] Atypical appearances including inho-
mogeneous calcification or bony changes may
be seen in high-grade lymphoma case reports
such as ocular adnexal diffuse large B-cell lym-
phoma (DLBCL) which is one of the more ag-
gressive type of OAL [7] Whole body PET is
used for not only the evaluation of systemic
involvement but also the standard for staging
lymphoma Our patientrsquos image studies revealed
neither obvious local invasion nor systemic ma-
lignancy indicating high-grade lymphoma was
less likely Low-grade lymphoma and benign
reactive lymphoid hyperplasia were still under
consideration
Histomorphology analysis and immunohisto-
chemistry (IHC) are essential for diagnosis
Flow cytometry and polymerase chain reaction
(PCR) technique are also applied to help differ-
entiate from RLH and OAL [1016] Our case
had immunohistochemical profile of positivity
for CD20 predominantly positivity focally for
CD3 CD5 CD10 CD23 and negativity for cy-
clin-D1 BCL-6 staining was not performed in
our casersquos biopsy Thus according to the IHC
report RLH ALH and follicular lymphoma are
probable diagnosis of our patient
Radiation therapy is the standard treatment for
low-grade OAL that is classified as T1N0M0 or
T2N0M0 according to the AJCC criteria [15]
İncesoy-Ouml zdemir S et al reported a 10-year-old
boy diagnosed of MALT lymphoma who was
treated with local radiotherapy (36 Gy) and
there were no local or systemic recurrences dur-
ing his nearly four-year follow-up [17] Another
case report represented a 21-year-old man of
conjunctival follicular lymphoma treated with
surgical excision only showing no evidence of
recurrence after 8 months follow-up [18] Other
treatment options for pediatric and juvenile OAL
were performed in some case reports including
intravenous rituximab intralesional interfer-
on-α-2b topical interferon a6 systemic doxycy-
cline surgical excision and postoperative local
cryotherapy [15]
Treatment for young conjunctival RLH was less
discussed in the past In a case series article
three children (9 13 14 years old respectively)
of RLH received surgical resection without fur-
ther postoperative management and no signs of
recurrence were noted during follow-up [19]
Short-term topical and oral corticosteroids after
surgical excision were prescribed in two pediat-
ric RLH patients for their small residual mass
However poor response in both cases was nota-
ble [20]
Our patient declined to receive radiotherapy or
any further postoperative treatment mainly due
to his concerning of possible side effects (such
as dry eye and cataract)
CONCLUSION We present a rare case of caruncle mass in this
report OALD is one of the relatively uncommon
diagnosis among caruncular lesions OALD
includes benign RLH and malignant OAL
which are both mainly seen in elderly patients
even rarer in pediatric or juvenile group
The standard treatment for low-grade OAL and
RLH in young patents are still debatable How-
ever long-term follow-up is suggested for both
OAL and RLH patients Though RLH has a be-
nign and self-limited course risk of malignant
transformation is possible
REFERENCES 1 Levy J Ilsar M Deckel Y et al Lesions of
the caruncle a description of 42 cases and
a review of the literature Eye
200923(5)1004-1018
2 C-Y Cheng and W-M Hsu Incidence of
eye cancer in Taiwan an 18-year review
Eye 200418152-158
3 Chui-Lien Tsen Muh-Chiou Lin
Youn-Shen Bee et al Ocular adnexal
lymphoma Five case reports and a
literature review Taiwan Journal of
Ophthalmology 20155(2)99-102
4 Liesegang TJ Ocular adnexal
lymphoproliferative lesions Mayo Clin
Proc 199368(10)1003-1010
5 Kirkegaard MM Coupland SE Prause JU
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
115
et al Malignant lymphoma of the
conjunctiva Surv Ophthalmol
201560(5)444-458
6 Stacy RC Jakobiec FA Schoenfield L et
al Unifocal and multifocal reactive
lymphoid hyperplasia vs follicular
lymphoma of the ocular adnexa Am J
Ophthalmol 2010150(3)412-426
7 Sullivan TJ Ocular Adnexal
Lymphoproliferative Disease In Guthoff
RF Katowitz JA eds Oculoplastics and
Orbit Berlin Heidelberg Springer
20101-19
8 White Valerie A Understanding and
Classification of Ocular Lymphomas
Ocular Oncology and Pathology
20195379-386
9 Stefanovic A Lossos IS Extranodal
marginal zone lymphoma of the ocular
adnexa Blood 2009114(3)501-510
10 Andrew NH Coupland SE Pirbhai A et al
Lymphoid hyperplasia of the orbit and
ocular adnexa A clinical pathologic review
Surv Ophthalmol 201661(6)778-790
11 Ferry JA1 Fung CY Zukerberg L et al
Lymphoma of the ocular adnexa A study
of 353 cases Am J Surg Pathol
200731(2)170-184
12 WM Hassan MS Bakry HM Hassan et al
Incidence of orbital conjunctival and
lacrimal gland malignant tumors in USA
from Surveillance Epidemiology and End
Results 1973-2009 Int J Ophthalmol
20169(12)1808-1813
13 Ajay A Rao John H Naheedy James Y-Y
Chen et al A Clinical Update and
Radiologic Review of Pediatric Orbital
and Ocular Tumors Journal of Oncology
2013(9)975908
14 Sullivan TJ Whitehead K Williamson R
et al Lymphoproliferative disease of the
ocular adnexa a clinical and pathologic
study with statistical analysis of 69
patients Ophthal Plast Reconstr Surg
200521177-188
15 Tanenbaum RE Galor A Dubovy SR et al
Classification diagnosis and management
of conjunctival lymphoma Eye Vis (Lond)
2019622
16 Olga Klavdianou Georgios Kondylis
Vasileios Georgopoulos et al Bilateral
benign reactive lymphoid hyperplasia of
the conjunctiva a case treated with oral
doxycycline and review of the literature
Eye Vis (Lond) 2019626
17 İncesoy-Ouml zdemir S Yuumlksek N Bozkurt C
et al A rare type of cancer in children
extranodal marginal zone B-cell (MALT)
lymphoma of the ocular adnexa Turk J
Pediatr 201456(3)295-298
18 Lynn J Poole Perry Frederick A Jakobiec
Peter A D Rubin Conjunctival Pediatric
Follicular Lymphoma Arch Ophthalmol
2012130(7)941-943
19 Abdullah Al-Mujaini Upender Wali
Anuradha Ganesh1 et al Ocular Adnexal
Reactive Lymphoid Hyperplasia in
Children Middle East Afr J Ophthalmol
201219(4)406-409
20 McLeod SD Edward DP Benign
lymphoid hyperplasia of the conjunctiva in
children Arch Ophthalmol
1999117(6)832-835
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
116
FIGURES
Figure 1 Slit lamp image of a mass lesion at the patientrsquos left eye caruncle for one month
Figure 2 One month after the first excision a protruding mass recurred at the patientrsquos nasal canthus
of left eye It partially involved beyond the gray line of nasal part lower eyelid
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
117
Figure 3 Histomorphology analysis and immunohistochemistry study of the caruncular lesion Abun-
dant atypical lymphoid proliferation presented in low-power photomicrograph (A) and
high-power photomicrograph (B) under hematoxylin-eosin staining The lymphoid aggrega-
tion was composed predominantly of CD20-positive cells (C) and focal positive staining of
CD3 (D)
Figure 4 Non-contrast orbital computed tomography showed a lesion of soft tissue density at medial
canthus of left orbit without obvious nasolacrimal duct or bony invasion (A) Magnetic reso-
nance imaging with contrast showed strong enhancement at left medial canthus region (B)
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
118
Figure 5 The follow-up photo were taken at three months after the second excision showing no signs
of recurrence
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
119
Juvenile Caruncular Atypical Lymphoid Proliferation ndash A Rare Case Report
罕見病例報告mdash青少年之淚阜非典型淋巴增生
施驊瑋 1林友祺 1
中文摘要
淚阜病灶相當罕見大部分為良性病灶眼睛及附屬結構淋巴增生疾病為其
鑑別診斷之一非常少見於年輕人或兒童我們報告一位 16歲的健康男性因
左眼淚阜無痛性腫塊接受切除手術卻於術後一個月復發執行第二次切除手術
後門診追蹤十個月未再復發此案例表現了部分良性與部分惡性腫瘤的特徵
我們針對反應性淋巴增生眼睛及附屬結構淋巴癌兩個疾病做討論及文獻回顧
關鍵字淚阜病灶眼睛及附屬結構淋巴增生疾病眼睛及附屬結構淋巴癌反
應性淋巴增生非典型淋巴增生
1 新光吳火獅紀念醫院眼科
通訊作者林友祺 電子信箱 yuchi067gmailcom
Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh 120
Submitted March 26 2020
Final version accepted April 16
2020
Case Report
Hyperacute intramembranous hemor-
rhage after burr hole craniostomy for
chronic subdural hematoma
Cite as Meng-Chi Lin Jui-Ming
Sun Yu-Hao Chen Cheng-Ta
Hsieh
Hyperacute intramembranous
hemorrhage after burr hole crani-
ostomy for chronic subdural he-
matoma Fu-Jen Journal of Medi-
cine 3(4) 120-125 2020
DOI
103966181020932020091803004
Meng-Chi Lin1 Jui-Ming Sun23 Yu-Hao Chen24 Cheng-Ta
Hsieh567
1Department of Surgery Zuoying Branch Kaohsiung Armed Forces
General Hospital Kaohsiung 813 Taiwan 2Section of Neurosurgery Department of Surgery Chia-Yi Christian
Hospital Chia-Yi City 600 Taiwan 3Department of Biotechnology Asia University Taichung City 41354
Taiwan 4Chung-Jen Junior College of Nursing Health Sciences and Manage-
ment Chia-Yi Country 62241 Taiwan 5Division of Neurosurgery Department of Surgery Sijhih Cathay Gen-
eral Hospital New Taipei City 22174 Taiwan 6Department of Medicine School of Medicine Fu Jen Catholic Univer-
sity New Taipei City 24205 Taiwan 7Department of Neurological Surgery Tri-Service General Hospital
National Defense Medical Center Taipei 114 Taiwan
Corresponding author E-mail address
nogormail2000comtw (Cheng-Ta Hsieh)
ABSTRACT
Burr hole craniostomy with closed-system drainage is an effective and common neurosurgical procedure to manage chronic subdural hematoma Postoperative hem-orrhage a well-known but infrequent complication may result in increased neurolog-ical deficits However hyperacute intramembranous hemorrhage within the inner and outer membrane of hematoma after burr hole craniostomy with irrigation and closed-system drainage has not been described previously Herein we report a case of postoperative spontaneous hyperacute intramembranous hemorrhage after burr hole craniostomy with closed-system drainage to manage a chronic subdural hematoma we subsequently discuss the possible pathophysiological mechanisms and review the relevant literature
Keywords Chronic subdural hematoma acute subdural hematoma bleeding burr hole craniostomy
drainage
Fu-J
Meng
INTChromostcal inof usubdmemthat draintechnvidehemowellacutecrani[7 8withacutehole pathorelev
CAA 61sion had tainiyearpartmNeurGlasher mities Scalwithsis nscanwithquencranidrainDuriin thsion hemasterilcloseHowfromrevesubdcranicraniof themoand
Jen Journal o
g-Chi Lin Ju
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Fu-Jen Journal of Medicine Vol 3 No 4 2020
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Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh
125
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
慢性硬腦膜下出血進行鑽顱引流手術造成超急性夾膜內出
血
林孟楫 1孫瑞明 23陳昱豪 24謝政達 567
中文摘要
鑽顱併封閉系統引流手術是治療慢性硬腦膜下出血患者一種有效且常見的
神經外科手術方式術後出血可能導致神經功能缺損惡化是眾所周知但不常見
的併發症之一然而至今仍未有鑽孔併封閉系統引流造成原本慢性硬腦膜血
塊內膜和外膜間急性夾膜間出血案例在這裡我們報告一例慢性硬腦膜下出
血病患者接受鑽顱併封閉系統引流手術治療造成術後急性夾膜間出血我們在
本文中討論可能的致病機制並回顧相關文獻
關鍵字慢性硬腦膜下出血急性硬腦膜下出血出血鑽顱術引流
1國軍高雄總醫院左營分院 外科部
2崇仁醫護管理專科學校
3亞洲大學 生物科技學系
4戴德森醫療財團法人嘉義基督教醫院 外科部 神經外科
5汐止國泰綜合醫院 神經外科
6輔仁大學 醫學系
7 國防醫學院 三軍總醫院 神經外科
通訊作者謝政達 電子信箱 nogormail2000comtw
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
126
Submitted January 21 2020
Final version accepted July 08
2020
Case Report
Hamartoma of the breast A case report
Cite as Hsuan-An Chen
Cheng-Yu Lo Shih-Hung Huang
Chin-Lung Lin
Hamartoma of the breast A case
report Fu-Jen Journal of Medicine
3(5) 126-130 2020
DOI
103966181020932020091803005
Hsuan-An Chen1 Cheng-Yu Lo
3 Shih-Hung Huang
3 Chin-Lung
Lin2
1Department of Surgery Cathay General Hospital Taipei Taiwan
2Department of General Surgery Cathay General Hospital Taipei Tai-
wan
3Department of Pathology Cathay General Hospital Taipei Taiwan
Corresponding author E-mail address
lungyungmailcom (Chin-Lung Lin)
ABSTRACT
Breast hamartoma is an uncommon benign tumor rarely associated with malignancy An
excision and histological examination is necessary for the differential diagnosis We report
a case of a 49-year-old female patient presenting with a lump in the right breast Ultrasound
examination which demonstrated a 4411 cm hypoechoic lesion with lipoma Partial mas-
tectomy was arranged and the diagnosis of a hamartoma was confirmed by the histological
examination
Keywords Breast tumor Hamartoma Ultrasound
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
127
INTRODUCTION The hamartoma is a benign tumor-like lesion
that can affect various organs of the body in-
cluding lungs kidneys skin and more rarely the
breast In 1981 the hamartomas were recognized
in the WHO classification[1] They are defined
as well-demarcated mass of mammary ducts and
lobules containing varying amounts of fibrous
and adipose tissue and producing a distinctive
mammographic image
CASE REPORT A 49 year-old female had past history of left
breast mastitis with abscess status post partial
mastectomy This time she presented to our out
patient clinic for breast examination Physical
examination revealed a painless palpable mova-
ble and painless lump at upper outer quadrant of
right breast The risk of breast cancer was not
noted and the patient did not have any family
history of breast cancer The patient also denied
any trauma history before Ultrasound examina-
tion was arranged which demonstrated a 4411
cm hypoechoic lesion with lipoma at 3 oclock 2
cm from nipple of right breast and multiple hy-
poechoic nodules of various size in both breasts
and there was no suspicious axillary lymph
nodes noted (Figure1) Surgical treatment was
arranged partial mastectomy of right breast
harmartoma was successfully performed A 32 x
31 x 21 cm tumor was completely excised
Grossly examination showed a gray to yellow
and firm to fatty The diagnosis of a hamartoma
was confirmed by the histological examination
Microscopically sections of the breast lesion
show mammary hamartoma composed of ducts
lobules with interlobular fibrous tissue and adi-
pose tissue Fibrocystic change apocrine meta-
plastic ducts and scattered foci of adenosis are
noted The overall lobulocentric architecture and
the 2-cell pattern of the epithelium are preserved
columnar cell change and focal microcalcifica-
tion are present (Figure2) Based on submitted
biopsy specimen in-situ or invasive tumor cells
are not identified
DISCUSSION Hamartoma of the breast is a benign tumor like
nodule it was also known as fibroadenolipoma
lipofibroadenoma or adenolipoma based on its
predominant components It was composed of
varying amounts of glandular adipose and fi-
brous tissue[2] Hamartomas were first described
in 1971 by Arrigoni et al in a study of 10 patients
which breast tumors clinically and grossly re-
sembled fibroadenomas[3]
A higher predominance of tumors exists in fe-
males compared with males Hamartomas are
slowly-growing lesions with the diameter rang-
ing from 2 cm to 5 cm sometimes hamartomas
can reach giant diameter [4]
The clinical diagnosis of hamartoma is based on
the findings from mammography sonography
and histology examinations The hamartomas are
usually incidentally diagnosed by the women
older than 40 year-old starting mammography
screening
On physicial examination harmatomas are usu-
ally occult painless they may be as large mo-
bile soft to firm masses[5] Ultrasound showed
well capsulated mass with echogenic rim and
internal heterogeneity Mammography exam
showed well-circumscribed round to oval
masses containing fat and soft tissue densities
with a thin radiopaque pseudocapsule The
pseudocapsule results from displacement of
breast parenchyma by the tumor [56] In Pa-
thology finding microglandular adenosis is pre-
sent in fibroadipose stroma surrounded by a thin
fibrous capsule It composed of a combination of
epithelial and stromal elements usually with
normal ducts or lobules although variations of
normal tissue may also be seen Fibroadenoli-
poma myoid hamartoma and chondrolipoma are
histological variations of hamartomas depend-
ing on the proportion of normal breast tissue
elements[7]
Malignancy associated with hamartomas are
very rare[8] However it has been reported
hamartomas develop into carcinoma Malignant
transformation can occur as a result of cellular
atypia in the epithelial component of the mass[9]
Surgical removal is the curative method for
breast hamartomas[10] Diagnostic material such
as mammography ultrasonography or core nee-
dle biopsy may not give the definitive diagnosis
Therefore surgical excision and histological
examination is necessary for differential diagno-
sis[111213]
Although it is rare hamartoma can be seen along
with malignancy as it is formed from similar
components of breast tissue Therefore careful
diagnosis and appropriate management including
surgery are required
REFERENCES 1 World Health Organization (1981)
Histological typing of breast tumors In
International histological classification of
tumors 1981 2nd ed
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
128
2 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11435ndash449
2006
3 ArrigoniMG DockertyMB JuddES
The identificationand treatment of
mammary hamartoma Surg Gynecol
Obstet1971 133 577-82
4 Sanal HT Ersoz N Altinel O Unal E Can
C Giant hamartoma of the breast Breast J
2006 12 84-85
5 Feder JM de Paredes ES Hogge JP
Wilken JJ Unusual breast lesions
radiologic-pathologic correlation
Radiographics 1999 19S11ndashS26
6 Murat A Ozdemir H Yildirim H Poyraz
AK Ozercan R Hamartoma of the breast
Australas Radiol 200751 Spec NoB37ndash
9
7 Fisher CJ Hanby AM Robinson L Millis
RR Mammary hamartoma-a review of 35
cases Histopathology 1992 20 99-106
8 Choi N Ko ES Invasive ductal carcinoma
in a mammary hamartoma case report and
review of the literature Korean J Radiol
2010 Nov-Dec11(6)687-91
9 Lee EH Wylie EJ Bourke AG Bastiaan
De Boer W Invasive ductal carcinoma
arising in a breast hamartoma two case
reports and a review of the literature Clin
Radiol 2003 58 80-3
10 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11 435 ‑449
2006
11 Coyne J Hobbs FM Boggis C Harland R
Lobular carcinoma in a mammary
hamartoma J Clin Pathol 199245936ndash
937
12 G M K Tse B K B Law T K F Ma A B W
Chan Hamartoma of the breast a
clinicopathological review J Clin Pathol
200255951ndash954
13 RAAmir SSheikh BreasthamartomaA
report of 14cases of an under-recognized
and under-reported entity International
Journal of Surgery Case Reports
22(2016)1ndash4
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
129
FIGURES
Figure 1 Ultrasound shows a 4411 cm hypoechoic lesion with lipoma at 3 oclock 2 cm from nipple
of right breast
Figure 2 Photomicrograph shows mammary hamartoma composed of ducts lobules with interlobular
fibrous tissue and adipose tissue
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
130
Hamartoma of the breast A case report
乳房錯構瘤罕見個案報告
陳宣安 1羅承裕 3黃世鴻 3林錦龍 2
中文摘要
乳房錯構瘤是一種罕見之乳房良性腫瘤切除手術及病理化驗來做鑑別診斷
我們報告一位 49歲女性以可觸摸到無痛性右側乳房腫塊為臨床表徵超音波
看到一個邊緣清楚低迴音的腫塊病患接受手術切除病灶病理診斷證實為乳
房錯構瘤
關鍵字乳房腫瘤錯構瘤超音波攝影
1國泰綜合醫院外科部
2國泰綜合醫院一般外科
3國泰綜合醫院病理科
通訊作者林錦龍 電子信箱 lungyungmailcom
Fu-Jen Journal of Medicine
Mission and Goals
The Fu-Jen Journal of Medicine (FJJM) is a peer-reviewed journal which
aims to enhance research quality of staffs in the College of Medicine Fu Jen
Catholic University The journal publishes original investigations across a
wide range of medical disciplines including original research articles in basic
and clinical sciences case reports review articles brief reports and letter
to the editor FJJM is now issued by the Center of Medical Education in the
College of Medicine Fu Jen Catholic University To promote journal quality
the manuscript submitted to FJJM after August first 2015 has to be prepared
in English to meet the international standards
Issue Date
Publication Date
Institution
December 01 2003
September 30 2020
College of Medicine Fu Jen Catholic University
Honorable publisher Han-Sun Chiang
Publisher Ping-Keung Yip
Editor-in-chief Ming-Chieh Ma
Associate Editors Yu-Wen Lin
Editors
Telephone (02) 2905-3477
Address Center for Medical Education College of Medicine Fu Jen
Catholic University
No 510 Zhongzheng Rd Xinzhuang Dist New Taipei City
24205 Taiwan
Su-Jane Wang Chi-Chung Wang Chih-Ming Ho
Yih-Jing Lee Chih-Shung Wong Tze-Wah Kao
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Chia-Chen Lu Zai-Ting Yeh
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Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 110
Failure to remove inadequate worn-out equipment in timely
manner
Failure to provide adequate operational information resources
Fail to provide adequate funding
Personnel Selec-
tion amp Staffing
Personnel recruiting amp selection policies are inadequate
Failure to provide adequate manning staffing resources
Policy amp Process
Issues
Pace of ops-tempoworkload
Organizational programpolicy risks not adequately assessed
Provided inadequate procedural guidance or publications
Organizational (formal) training is inadequate or unavailable
Flawed doctrinephilosophy
Inadequate program management
Purchasing or providing poorly designed or unsuitable equip-
ment
ClimateCulture
Influences
Organizational culture (attitude actions) allows for unsafe
taskmission
Organizational over-confidence or under-confidence in equip-
ment
Unit missionaircraftvehicleequipment change or unit deacti-
vation
Organizational structure is unclear or inadequate
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 111
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
以 HFACS重新檢視根本原因分析案例挖掘造成醫療不良
事件之人為因素
鄭伃洵 1洪聖惠 12柯彤文 3王拔群 14
中文摘要
背景醫療不良事件(AMEs)的管理是促進病人安全的基石根本原因分析
(RCA)是探討重大病人安全不良事件問題但是由於無法解釋更廣泛的因素而受
到限制本研究使用人為因素分類與分析工具(HFACS)回溯審視醫療不良事件
以了解影響醫療不良事件的人為因素及各層面中錯誤原因之分佈或系統性問題
方法本研究回溯 2012-2016年間有做過根本原因分析之醫療不良事件以連續
性取樣方式(continuous sampling)收集 40例醫療不良事件以人為因素分類與分
析工具(HFACS)去系統性的挖掘每件案例發生錯誤之原因結果在行為層面中
分析結果主要為基礎技能錯誤(95)判斷和決策錯誤(875)其中在基礎技能
錯誤當中以未依程序作業執行(816)及未如預期設備操作(50)佔多數判斷和
決策錯誤中以現場風險評估不確實(686)及採取錯的步驟行為(686)佔多數
而在先決條件層面中以團隊合作(275)為主要因素包含溝通不良(818)及重
要訊息未以正確的方式即時傳達(727)佔多數在監督層面當中以監督不周
(929)或監督不妥當(929)為主要因素在組織政策和流程方面(50)以組織
系統的政策風險未充分評估(35)為主要因素結論本研究進一步了解醫療不
良事件在過去使用根本原因分析未探討到的人為因素反映出潛在的監督組織
行為或系統性的問題促進病人安全預防錯誤再發生
關鍵字病人安全醫療不良事件根本原因分析人為因素
1國泰醫療財團法人國泰綜合醫院 品質管理部
2國立臺灣大學健康政策與管理研究所
3振興醫療財團法人振興醫院 醫療品質管理中心
4輔仁大學醫學院
通訊作者王拔群 電子信箱 drtonyseednettw
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin 112
Submitted January 20 2020
Final version accepted April13
2020
Case Report
Juvenile Caruncular Atypical Lymphoid
Proliferation ndash A Rare Case Report
Cite as Hua-Wei Shih Yu-Chi Lin
Juvenile Caruncular Atypical
Lymphoid Proliferation ndash A Rare
Case Report Fu-Jen Journal of
Medicine 3(3) 112-119 2020
DOI
103966181020932020091803003
Hua-Wei Shih1 Yu-Chi Lin
1
1Department of Ophthalmology Shin Kong Wu Ho-Su Memorial Hos-
pital Taipei City Taiwan
Corresponding author E-mail address
yuchi067gmailcom (Yu-Chi Lin)
ABSTRACT
Lesions of the caruncle are very rare Most caruncular lesions are benign though there were still few reported malignant lesions Ocular adnexal lymphoproliferative disease (OALD) one of the differential diagnosis of caruncular lesion is seldom seen in young pa-tient In this article we report a 16-year-old boy with recurrent caruncular atypical lym-phoid proliferation We discuss the epidemiology clinical features images histomorpholo-gy and treatment between ocular adnexal lymphomas (OAL) and reactive lymphoid hyper-plasia (RLH)
Keywords caruncular lesion ocular adnexal lymphoproliferative disease ocular adnexal lymphoma
reactive lymphoid hyperplasia atypical lymphoid proliferation
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
113
INTRODUCTION Lesions of the caruncle are very rare Differen-
tial diagnosis includes nevus myeloproliferative
disorders tumors inflammation infection cysts
vascular lesions and fibrous Biopsy is essential
for diagnosis Levy J et al reported ocular ad-
nexal lymphoproliferative disease (OALD) was
relatively uncommon diagnosis among caruncu-
lar lesions [1]
OALD was seldom described in Asian popula-
tion especially for young age C-Y Cheng re-
ported age-standardized incidence of ocular
adnexal lymphomas (OAL) in Taiwan from 1979
to 1996 was below 07 per million per year and
mean age was 531 years old [2] In 2015 five
Taiwanese cases of OAL whose age ranging
from 45 to 64 were presented [3] However
there were few cases of conjunctival OAL or
RLH in Chinese pediatric patient
Here we present a case of 16-year-old boy with a
caruncular mass at his left eye with recurrence
one month after excision We describe his clini-
cal symptoms photographs pathological results
management and follow-up clinical course in
this report
CASE REPORT A 16-year-old healthy boy presented a mass
lesion at his left eye caruncle accompanied with
the symptom of tearing for one month (Figure 1)
He had no ocular pain no itchiness no blurred
vision no night sweating no fever and no body
weight loss The patient denied systemic diseas-
es and histories of surgery His bilateral best
corrected visual acuity (BCVA) were 66 and
intraocular pressure (IOP) were both within
normal range There were no remarkable find-
ings for his cornea lens fundus and physical
examination Excision was performed and the
mass was soft with fluid inside therefore con-
junctival pyogenic cyst was our initial diagnosis
However one month after the excision a pro-
truding mass recurred at the patientrsquos nasal can-
thus of left eye (Figure 2) There were some
differences compared to previous condition At
the first time the soft mass was contained in a
well-defined cyst wall which more favored py-
ogenic granulation However after short period
of recurrence solid consistency and unclear
margin were found which favored malignancy
Besides the mass partially involved beyond the
gray line of nasal part lower eyelid whereas last
time the cyst mainly extended from conjunctiva
of caruncle The second excisional biopsy was
performed Pathologic examination demonstrat-
ed abundant atypical lymphoid proliferation
(Figure 3A 3B) Immunohistochemical studies
showed that the lymphoid aggregation was
composed predominantly of CD20-positive cells
(Figure 3C) focal positive staining of CD3
(Figure 3D) CD5 CD23 CD10 and negative
staining of cyclin-D1 Unfortunately the cellular
morphology was difficult to be evaluated due to
marked crushing artifact Thus malignant lym-
phoma cannot be excluded totally
Orbital computed tomography (CT) showed a
lesion of soft tissue density at medial canthus of
left orbit without obvious nasolacrimal duct or
bony invasion (Figure 4A) Magnetic resonance
imaging (MRI) with contrast showed strong
enhancement at left medial canthus region (Fig-
ure 4B) There was no remarkable finding in the
systemic workup including complete blood
count and differential count biochemical pro-
files and 18F-fluoro-2-deoxyglucose positron
emission tomographycomputed tomography
(18F-FDG PETCT) indicating no evidence of
systemic involvement
After the second excision we preferred con-
servative management for him due to the uncer-
tainty of malignancy and to avoid side effects
from aggressive treatment No sign of recurrence
was noted after 10 months of observation The
follow-up photo was taken at three months after
the second operation (Figure 5)
DISCUSSION Ocular adnexal lymphoproliferative disease
(OALD) consists of the spectrum of lymphoid
disease affecting the tissues surrounding the eye
including ocular adnexal lymphomas (OAL) and
lymphoid hyperplasia (LH) [4] The conjunctiva
is an important location for extranodal lympho-
ma development which comprises 25 of OAL
[5]
OAL can be grouped into two categories based
on their appearance of cells under the micro-
scope low-grade and high-grade [6] Extranodal
marginal zone lymphoma of mucosa-associated
lymphoid tissue (EMZLMALT) is the most
common subtype of OAL followed by follicular
lymphoma [7-9] Both of the above are
low-grade lymphomas
LH can be further divided by histopathology into
reactive lymphoid hyperplasia (RLH) and atypi-
cal lymphoid hyperplasia (ALH) RLH has to-
tally benign morphology and immunophenotype
whereas ALH has borderline lesions between
RLH and lymphoma [10] OAL and LH are
mostly seen in patients with age between 50-70
years old There are rare cases in pediatric group
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
114
[71011] In the C-Y Chengrsquos statistical report of
OAL in Taiwan only 8 patients were younger
than 15 years old among the 101 cases of ocular
lymphoma [2] According to an US study inci-
dence rates of OAL were analyzed in different
age groups the group of age over 50 had the
highest incidence rate of 574 per million per-
son-years while the 0-19 age group had the
lowest incidence rate of 009 per million per-
son-years [12] The incidence of LH was even
less than OAL [13]
Patients with OALD may be asymptomatic or
with symptoms of proptosis eyelid swelling a
palpable painless mass or conjunctival salmon
patch Diplopia visual loss pain or inflamma-
tion occurred less frequently implying more
aggressive features [714]
Orbital LH is not distinguishable from low-grade
lymphoma radiologically They both typically
present a round or lobulated mass that diffusely
moderately enhances with contrast and usually
shows homogenous hypointense or isointense to
muscle barely invasion to bone or nervous sys-
tem [10] Atypical appearances including inho-
mogeneous calcification or bony changes may
be seen in high-grade lymphoma case reports
such as ocular adnexal diffuse large B-cell lym-
phoma (DLBCL) which is one of the more ag-
gressive type of OAL [7] Whole body PET is
used for not only the evaluation of systemic
involvement but also the standard for staging
lymphoma Our patientrsquos image studies revealed
neither obvious local invasion nor systemic ma-
lignancy indicating high-grade lymphoma was
less likely Low-grade lymphoma and benign
reactive lymphoid hyperplasia were still under
consideration
Histomorphology analysis and immunohisto-
chemistry (IHC) are essential for diagnosis
Flow cytometry and polymerase chain reaction
(PCR) technique are also applied to help differ-
entiate from RLH and OAL [1016] Our case
had immunohistochemical profile of positivity
for CD20 predominantly positivity focally for
CD3 CD5 CD10 CD23 and negativity for cy-
clin-D1 BCL-6 staining was not performed in
our casersquos biopsy Thus according to the IHC
report RLH ALH and follicular lymphoma are
probable diagnosis of our patient
Radiation therapy is the standard treatment for
low-grade OAL that is classified as T1N0M0 or
T2N0M0 according to the AJCC criteria [15]
İncesoy-Ouml zdemir S et al reported a 10-year-old
boy diagnosed of MALT lymphoma who was
treated with local radiotherapy (36 Gy) and
there were no local or systemic recurrences dur-
ing his nearly four-year follow-up [17] Another
case report represented a 21-year-old man of
conjunctival follicular lymphoma treated with
surgical excision only showing no evidence of
recurrence after 8 months follow-up [18] Other
treatment options for pediatric and juvenile OAL
were performed in some case reports including
intravenous rituximab intralesional interfer-
on-α-2b topical interferon a6 systemic doxycy-
cline surgical excision and postoperative local
cryotherapy [15]
Treatment for young conjunctival RLH was less
discussed in the past In a case series article
three children (9 13 14 years old respectively)
of RLH received surgical resection without fur-
ther postoperative management and no signs of
recurrence were noted during follow-up [19]
Short-term topical and oral corticosteroids after
surgical excision were prescribed in two pediat-
ric RLH patients for their small residual mass
However poor response in both cases was nota-
ble [20]
Our patient declined to receive radiotherapy or
any further postoperative treatment mainly due
to his concerning of possible side effects (such
as dry eye and cataract)
CONCLUSION We present a rare case of caruncle mass in this
report OALD is one of the relatively uncommon
diagnosis among caruncular lesions OALD
includes benign RLH and malignant OAL
which are both mainly seen in elderly patients
even rarer in pediatric or juvenile group
The standard treatment for low-grade OAL and
RLH in young patents are still debatable How-
ever long-term follow-up is suggested for both
OAL and RLH patients Though RLH has a be-
nign and self-limited course risk of malignant
transformation is possible
REFERENCES 1 Levy J Ilsar M Deckel Y et al Lesions of
the caruncle a description of 42 cases and
a review of the literature Eye
200923(5)1004-1018
2 C-Y Cheng and W-M Hsu Incidence of
eye cancer in Taiwan an 18-year review
Eye 200418152-158
3 Chui-Lien Tsen Muh-Chiou Lin
Youn-Shen Bee et al Ocular adnexal
lymphoma Five case reports and a
literature review Taiwan Journal of
Ophthalmology 20155(2)99-102
4 Liesegang TJ Ocular adnexal
lymphoproliferative lesions Mayo Clin
Proc 199368(10)1003-1010
5 Kirkegaard MM Coupland SE Prause JU
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
115
et al Malignant lymphoma of the
conjunctiva Surv Ophthalmol
201560(5)444-458
6 Stacy RC Jakobiec FA Schoenfield L et
al Unifocal and multifocal reactive
lymphoid hyperplasia vs follicular
lymphoma of the ocular adnexa Am J
Ophthalmol 2010150(3)412-426
7 Sullivan TJ Ocular Adnexal
Lymphoproliferative Disease In Guthoff
RF Katowitz JA eds Oculoplastics and
Orbit Berlin Heidelberg Springer
20101-19
8 White Valerie A Understanding and
Classification of Ocular Lymphomas
Ocular Oncology and Pathology
20195379-386
9 Stefanovic A Lossos IS Extranodal
marginal zone lymphoma of the ocular
adnexa Blood 2009114(3)501-510
10 Andrew NH Coupland SE Pirbhai A et al
Lymphoid hyperplasia of the orbit and
ocular adnexa A clinical pathologic review
Surv Ophthalmol 201661(6)778-790
11 Ferry JA1 Fung CY Zukerberg L et al
Lymphoma of the ocular adnexa A study
of 353 cases Am J Surg Pathol
200731(2)170-184
12 WM Hassan MS Bakry HM Hassan et al
Incidence of orbital conjunctival and
lacrimal gland malignant tumors in USA
from Surveillance Epidemiology and End
Results 1973-2009 Int J Ophthalmol
20169(12)1808-1813
13 Ajay A Rao John H Naheedy James Y-Y
Chen et al A Clinical Update and
Radiologic Review of Pediatric Orbital
and Ocular Tumors Journal of Oncology
2013(9)975908
14 Sullivan TJ Whitehead K Williamson R
et al Lymphoproliferative disease of the
ocular adnexa a clinical and pathologic
study with statistical analysis of 69
patients Ophthal Plast Reconstr Surg
200521177-188
15 Tanenbaum RE Galor A Dubovy SR et al
Classification diagnosis and management
of conjunctival lymphoma Eye Vis (Lond)
2019622
16 Olga Klavdianou Georgios Kondylis
Vasileios Georgopoulos et al Bilateral
benign reactive lymphoid hyperplasia of
the conjunctiva a case treated with oral
doxycycline and review of the literature
Eye Vis (Lond) 2019626
17 İncesoy-Ouml zdemir S Yuumlksek N Bozkurt C
et al A rare type of cancer in children
extranodal marginal zone B-cell (MALT)
lymphoma of the ocular adnexa Turk J
Pediatr 201456(3)295-298
18 Lynn J Poole Perry Frederick A Jakobiec
Peter A D Rubin Conjunctival Pediatric
Follicular Lymphoma Arch Ophthalmol
2012130(7)941-943
19 Abdullah Al-Mujaini Upender Wali
Anuradha Ganesh1 et al Ocular Adnexal
Reactive Lymphoid Hyperplasia in
Children Middle East Afr J Ophthalmol
201219(4)406-409
20 McLeod SD Edward DP Benign
lymphoid hyperplasia of the conjunctiva in
children Arch Ophthalmol
1999117(6)832-835
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
116
FIGURES
Figure 1 Slit lamp image of a mass lesion at the patientrsquos left eye caruncle for one month
Figure 2 One month after the first excision a protruding mass recurred at the patientrsquos nasal canthus
of left eye It partially involved beyond the gray line of nasal part lower eyelid
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
117
Figure 3 Histomorphology analysis and immunohistochemistry study of the caruncular lesion Abun-
dant atypical lymphoid proliferation presented in low-power photomicrograph (A) and
high-power photomicrograph (B) under hematoxylin-eosin staining The lymphoid aggrega-
tion was composed predominantly of CD20-positive cells (C) and focal positive staining of
CD3 (D)
Figure 4 Non-contrast orbital computed tomography showed a lesion of soft tissue density at medial
canthus of left orbit without obvious nasolacrimal duct or bony invasion (A) Magnetic reso-
nance imaging with contrast showed strong enhancement at left medial canthus region (B)
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
118
Figure 5 The follow-up photo were taken at three months after the second excision showing no signs
of recurrence
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
119
Juvenile Caruncular Atypical Lymphoid Proliferation ndash A Rare Case Report
罕見病例報告mdash青少年之淚阜非典型淋巴增生
施驊瑋 1林友祺 1
中文摘要
淚阜病灶相當罕見大部分為良性病灶眼睛及附屬結構淋巴增生疾病為其
鑑別診斷之一非常少見於年輕人或兒童我們報告一位 16歲的健康男性因
左眼淚阜無痛性腫塊接受切除手術卻於術後一個月復發執行第二次切除手術
後門診追蹤十個月未再復發此案例表現了部分良性與部分惡性腫瘤的特徵
我們針對反應性淋巴增生眼睛及附屬結構淋巴癌兩個疾病做討論及文獻回顧
關鍵字淚阜病灶眼睛及附屬結構淋巴增生疾病眼睛及附屬結構淋巴癌反
應性淋巴增生非典型淋巴增生
1 新光吳火獅紀念醫院眼科
通訊作者林友祺 電子信箱 yuchi067gmailcom
Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh 120
Submitted March 26 2020
Final version accepted April 16
2020
Case Report
Hyperacute intramembranous hemor-
rhage after burr hole craniostomy for
chronic subdural hematoma
Cite as Meng-Chi Lin Jui-Ming
Sun Yu-Hao Chen Cheng-Ta
Hsieh
Hyperacute intramembranous
hemorrhage after burr hole crani-
ostomy for chronic subdural he-
matoma Fu-Jen Journal of Medi-
cine 3(4) 120-125 2020
DOI
103966181020932020091803004
Meng-Chi Lin1 Jui-Ming Sun23 Yu-Hao Chen24 Cheng-Ta
Hsieh567
1Department of Surgery Zuoying Branch Kaohsiung Armed Forces
General Hospital Kaohsiung 813 Taiwan 2Section of Neurosurgery Department of Surgery Chia-Yi Christian
Hospital Chia-Yi City 600 Taiwan 3Department of Biotechnology Asia University Taichung City 41354
Taiwan 4Chung-Jen Junior College of Nursing Health Sciences and Manage-
ment Chia-Yi Country 62241 Taiwan 5Division of Neurosurgery Department of Surgery Sijhih Cathay Gen-
eral Hospital New Taipei City 22174 Taiwan 6Department of Medicine School of Medicine Fu Jen Catholic Univer-
sity New Taipei City 24205 Taiwan 7Department of Neurological Surgery Tri-Service General Hospital
National Defense Medical Center Taipei 114 Taiwan
Corresponding author E-mail address
nogormail2000comtw (Cheng-Ta Hsieh)
ABSTRACT
Burr hole craniostomy with closed-system drainage is an effective and common neurosurgical procedure to manage chronic subdural hematoma Postoperative hem-orrhage a well-known but infrequent complication may result in increased neurolog-ical deficits However hyperacute intramembranous hemorrhage within the inner and outer membrane of hematoma after burr hole craniostomy with irrigation and closed-system drainage has not been described previously Herein we report a case of postoperative spontaneous hyperacute intramembranous hemorrhage after burr hole craniostomy with closed-system drainage to manage a chronic subdural hematoma we subsequently discuss the possible pathophysiological mechanisms and review the relevant literature
Keywords Chronic subdural hematoma acute subdural hematoma bleeding burr hole craniostomy
drainage
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Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh
125
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
慢性硬腦膜下出血進行鑽顱引流手術造成超急性夾膜內出
血
林孟楫 1孫瑞明 23陳昱豪 24謝政達 567
中文摘要
鑽顱併封閉系統引流手術是治療慢性硬腦膜下出血患者一種有效且常見的
神經外科手術方式術後出血可能導致神經功能缺損惡化是眾所周知但不常見
的併發症之一然而至今仍未有鑽孔併封閉系統引流造成原本慢性硬腦膜血
塊內膜和外膜間急性夾膜間出血案例在這裡我們報告一例慢性硬腦膜下出
血病患者接受鑽顱併封閉系統引流手術治療造成術後急性夾膜間出血我們在
本文中討論可能的致病機制並回顧相關文獻
關鍵字慢性硬腦膜下出血急性硬腦膜下出血出血鑽顱術引流
1國軍高雄總醫院左營分院 外科部
2崇仁醫護管理專科學校
3亞洲大學 生物科技學系
4戴德森醫療財團法人嘉義基督教醫院 外科部 神經外科
5汐止國泰綜合醫院 神經外科
6輔仁大學 醫學系
7 國防醫學院 三軍總醫院 神經外科
通訊作者謝政達 電子信箱 nogormail2000comtw
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
126
Submitted January 21 2020
Final version accepted July 08
2020
Case Report
Hamartoma of the breast A case report
Cite as Hsuan-An Chen
Cheng-Yu Lo Shih-Hung Huang
Chin-Lung Lin
Hamartoma of the breast A case
report Fu-Jen Journal of Medicine
3(5) 126-130 2020
DOI
103966181020932020091803005
Hsuan-An Chen1 Cheng-Yu Lo
3 Shih-Hung Huang
3 Chin-Lung
Lin2
1Department of Surgery Cathay General Hospital Taipei Taiwan
2Department of General Surgery Cathay General Hospital Taipei Tai-
wan
3Department of Pathology Cathay General Hospital Taipei Taiwan
Corresponding author E-mail address
lungyungmailcom (Chin-Lung Lin)
ABSTRACT
Breast hamartoma is an uncommon benign tumor rarely associated with malignancy An
excision and histological examination is necessary for the differential diagnosis We report
a case of a 49-year-old female patient presenting with a lump in the right breast Ultrasound
examination which demonstrated a 4411 cm hypoechoic lesion with lipoma Partial mas-
tectomy was arranged and the diagnosis of a hamartoma was confirmed by the histological
examination
Keywords Breast tumor Hamartoma Ultrasound
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
127
INTRODUCTION The hamartoma is a benign tumor-like lesion
that can affect various organs of the body in-
cluding lungs kidneys skin and more rarely the
breast In 1981 the hamartomas were recognized
in the WHO classification[1] They are defined
as well-demarcated mass of mammary ducts and
lobules containing varying amounts of fibrous
and adipose tissue and producing a distinctive
mammographic image
CASE REPORT A 49 year-old female had past history of left
breast mastitis with abscess status post partial
mastectomy This time she presented to our out
patient clinic for breast examination Physical
examination revealed a painless palpable mova-
ble and painless lump at upper outer quadrant of
right breast The risk of breast cancer was not
noted and the patient did not have any family
history of breast cancer The patient also denied
any trauma history before Ultrasound examina-
tion was arranged which demonstrated a 4411
cm hypoechoic lesion with lipoma at 3 oclock 2
cm from nipple of right breast and multiple hy-
poechoic nodules of various size in both breasts
and there was no suspicious axillary lymph
nodes noted (Figure1) Surgical treatment was
arranged partial mastectomy of right breast
harmartoma was successfully performed A 32 x
31 x 21 cm tumor was completely excised
Grossly examination showed a gray to yellow
and firm to fatty The diagnosis of a hamartoma
was confirmed by the histological examination
Microscopically sections of the breast lesion
show mammary hamartoma composed of ducts
lobules with interlobular fibrous tissue and adi-
pose tissue Fibrocystic change apocrine meta-
plastic ducts and scattered foci of adenosis are
noted The overall lobulocentric architecture and
the 2-cell pattern of the epithelium are preserved
columnar cell change and focal microcalcifica-
tion are present (Figure2) Based on submitted
biopsy specimen in-situ or invasive tumor cells
are not identified
DISCUSSION Hamartoma of the breast is a benign tumor like
nodule it was also known as fibroadenolipoma
lipofibroadenoma or adenolipoma based on its
predominant components It was composed of
varying amounts of glandular adipose and fi-
brous tissue[2] Hamartomas were first described
in 1971 by Arrigoni et al in a study of 10 patients
which breast tumors clinically and grossly re-
sembled fibroadenomas[3]
A higher predominance of tumors exists in fe-
males compared with males Hamartomas are
slowly-growing lesions with the diameter rang-
ing from 2 cm to 5 cm sometimes hamartomas
can reach giant diameter [4]
The clinical diagnosis of hamartoma is based on
the findings from mammography sonography
and histology examinations The hamartomas are
usually incidentally diagnosed by the women
older than 40 year-old starting mammography
screening
On physicial examination harmatomas are usu-
ally occult painless they may be as large mo-
bile soft to firm masses[5] Ultrasound showed
well capsulated mass with echogenic rim and
internal heterogeneity Mammography exam
showed well-circumscribed round to oval
masses containing fat and soft tissue densities
with a thin radiopaque pseudocapsule The
pseudocapsule results from displacement of
breast parenchyma by the tumor [56] In Pa-
thology finding microglandular adenosis is pre-
sent in fibroadipose stroma surrounded by a thin
fibrous capsule It composed of a combination of
epithelial and stromal elements usually with
normal ducts or lobules although variations of
normal tissue may also be seen Fibroadenoli-
poma myoid hamartoma and chondrolipoma are
histological variations of hamartomas depend-
ing on the proportion of normal breast tissue
elements[7]
Malignancy associated with hamartomas are
very rare[8] However it has been reported
hamartomas develop into carcinoma Malignant
transformation can occur as a result of cellular
atypia in the epithelial component of the mass[9]
Surgical removal is the curative method for
breast hamartomas[10] Diagnostic material such
as mammography ultrasonography or core nee-
dle biopsy may not give the definitive diagnosis
Therefore surgical excision and histological
examination is necessary for differential diagno-
sis[111213]
Although it is rare hamartoma can be seen along
with malignancy as it is formed from similar
components of breast tissue Therefore careful
diagnosis and appropriate management including
surgery are required
REFERENCES 1 World Health Organization (1981)
Histological typing of breast tumors In
International histological classification of
tumors 1981 2nd ed
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
128
2 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11435ndash449
2006
3 ArrigoniMG DockertyMB JuddES
The identificationand treatment of
mammary hamartoma Surg Gynecol
Obstet1971 133 577-82
4 Sanal HT Ersoz N Altinel O Unal E Can
C Giant hamartoma of the breast Breast J
2006 12 84-85
5 Feder JM de Paredes ES Hogge JP
Wilken JJ Unusual breast lesions
radiologic-pathologic correlation
Radiographics 1999 19S11ndashS26
6 Murat A Ozdemir H Yildirim H Poyraz
AK Ozercan R Hamartoma of the breast
Australas Radiol 200751 Spec NoB37ndash
9
7 Fisher CJ Hanby AM Robinson L Millis
RR Mammary hamartoma-a review of 35
cases Histopathology 1992 20 99-106
8 Choi N Ko ES Invasive ductal carcinoma
in a mammary hamartoma case report and
review of the literature Korean J Radiol
2010 Nov-Dec11(6)687-91
9 Lee EH Wylie EJ Bourke AG Bastiaan
De Boer W Invasive ductal carcinoma
arising in a breast hamartoma two case
reports and a review of the literature Clin
Radiol 2003 58 80-3
10 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11 435 ‑449
2006
11 Coyne J Hobbs FM Boggis C Harland R
Lobular carcinoma in a mammary
hamartoma J Clin Pathol 199245936ndash
937
12 G M K Tse B K B Law T K F Ma A B W
Chan Hamartoma of the breast a
clinicopathological review J Clin Pathol
200255951ndash954
13 RAAmir SSheikh BreasthamartomaA
report of 14cases of an under-recognized
and under-reported entity International
Journal of Surgery Case Reports
22(2016)1ndash4
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
129
FIGURES
Figure 1 Ultrasound shows a 4411 cm hypoechoic lesion with lipoma at 3 oclock 2 cm from nipple
of right breast
Figure 2 Photomicrograph shows mammary hamartoma composed of ducts lobules with interlobular
fibrous tissue and adipose tissue
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
130
Hamartoma of the breast A case report
乳房錯構瘤罕見個案報告
陳宣安 1羅承裕 3黃世鴻 3林錦龍 2
中文摘要
乳房錯構瘤是一種罕見之乳房良性腫瘤切除手術及病理化驗來做鑑別診斷
我們報告一位 49歲女性以可觸摸到無痛性右側乳房腫塊為臨床表徵超音波
看到一個邊緣清楚低迴音的腫塊病患接受手術切除病灶病理診斷證實為乳
房錯構瘤
關鍵字乳房腫瘤錯構瘤超音波攝影
1國泰綜合醫院外科部
2國泰綜合醫院一般外科
3國泰綜合醫院病理科
通訊作者林錦龍 電子信箱 lungyungmailcom
Fu-Jen Journal of Medicine
Mission and Goals
The Fu-Jen Journal of Medicine (FJJM) is a peer-reviewed journal which
aims to enhance research quality of staffs in the College of Medicine Fu Jen
Catholic University The journal publishes original investigations across a
wide range of medical disciplines including original research articles in basic
and clinical sciences case reports review articles brief reports and letter
to the editor FJJM is now issued by the Center of Medical Education in the
College of Medicine Fu Jen Catholic University To promote journal quality
the manuscript submitted to FJJM after August first 2015 has to be prepared
in English to meet the international standards
Issue Date
Publication Date
Institution
December 01 2003
September 30 2020
College of Medicine Fu Jen Catholic University
Honorable publisher Han-Sun Chiang
Publisher Ping-Keung Yip
Editor-in-chief Ming-Chieh Ma
Associate Editors Yu-Wen Lin
Editors
Telephone (02) 2905-3477
Address Center for Medical Education College of Medicine Fu Jen
Catholic University
No 510 Zhongzheng Rd Xinzhuang Dist New Taipei City
24205 Taiwan
Su-Jane Wang Chi-Chung Wang Chih-Ming Ho
Yih-Jing Lee Chih-Shung Wong Tze-Wah Kao
Chi-Feng Hung Rung-Fen Feng Chee-Fah Chogn
Chia-Chen Lu Zai-Ting Yeh
Dee Pei Chih-Kuang Liu
Hen-Hui Lien Chien-Hsiou Liu
Chun-Hou Liao Yi-Ju Tsai Sheng-Wen Teng
Chia-Ting Su
- 9月封面
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- 2020九月刊排版NO1_完稿
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-
Fu-Jen Journal of Medicine Vol 3 No 2 2020
Retrospect RCA with HFACS
Yu-Hsun Cheng Sheng-Hui Hung Tung-Wen Ko Pa-Chun Wang 111
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
以 HFACS重新檢視根本原因分析案例挖掘造成醫療不良
事件之人為因素
鄭伃洵 1洪聖惠 12柯彤文 3王拔群 14
中文摘要
背景醫療不良事件(AMEs)的管理是促進病人安全的基石根本原因分析
(RCA)是探討重大病人安全不良事件問題但是由於無法解釋更廣泛的因素而受
到限制本研究使用人為因素分類與分析工具(HFACS)回溯審視醫療不良事件
以了解影響醫療不良事件的人為因素及各層面中錯誤原因之分佈或系統性問題
方法本研究回溯 2012-2016年間有做過根本原因分析之醫療不良事件以連續
性取樣方式(continuous sampling)收集 40例醫療不良事件以人為因素分類與分
析工具(HFACS)去系統性的挖掘每件案例發生錯誤之原因結果在行為層面中
分析結果主要為基礎技能錯誤(95)判斷和決策錯誤(875)其中在基礎技能
錯誤當中以未依程序作業執行(816)及未如預期設備操作(50)佔多數判斷和
決策錯誤中以現場風險評估不確實(686)及採取錯的步驟行為(686)佔多數
而在先決條件層面中以團隊合作(275)為主要因素包含溝通不良(818)及重
要訊息未以正確的方式即時傳達(727)佔多數在監督層面當中以監督不周
(929)或監督不妥當(929)為主要因素在組織政策和流程方面(50)以組織
系統的政策風險未充分評估(35)為主要因素結論本研究進一步了解醫療不
良事件在過去使用根本原因分析未探討到的人為因素反映出潛在的監督組織
行為或系統性的問題促進病人安全預防錯誤再發生
關鍵字病人安全醫療不良事件根本原因分析人為因素
1國泰醫療財團法人國泰綜合醫院 品質管理部
2國立臺灣大學健康政策與管理研究所
3振興醫療財團法人振興醫院 醫療品質管理中心
4輔仁大學醫學院
通訊作者王拔群 電子信箱 drtonyseednettw
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin 112
Submitted January 20 2020
Final version accepted April13
2020
Case Report
Juvenile Caruncular Atypical Lymphoid
Proliferation ndash A Rare Case Report
Cite as Hua-Wei Shih Yu-Chi Lin
Juvenile Caruncular Atypical
Lymphoid Proliferation ndash A Rare
Case Report Fu-Jen Journal of
Medicine 3(3) 112-119 2020
DOI
103966181020932020091803003
Hua-Wei Shih1 Yu-Chi Lin
1
1Department of Ophthalmology Shin Kong Wu Ho-Su Memorial Hos-
pital Taipei City Taiwan
Corresponding author E-mail address
yuchi067gmailcom (Yu-Chi Lin)
ABSTRACT
Lesions of the caruncle are very rare Most caruncular lesions are benign though there were still few reported malignant lesions Ocular adnexal lymphoproliferative disease (OALD) one of the differential diagnosis of caruncular lesion is seldom seen in young pa-tient In this article we report a 16-year-old boy with recurrent caruncular atypical lym-phoid proliferation We discuss the epidemiology clinical features images histomorpholo-gy and treatment between ocular adnexal lymphomas (OAL) and reactive lymphoid hyper-plasia (RLH)
Keywords caruncular lesion ocular adnexal lymphoproliferative disease ocular adnexal lymphoma
reactive lymphoid hyperplasia atypical lymphoid proliferation
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
113
INTRODUCTION Lesions of the caruncle are very rare Differen-
tial diagnosis includes nevus myeloproliferative
disorders tumors inflammation infection cysts
vascular lesions and fibrous Biopsy is essential
for diagnosis Levy J et al reported ocular ad-
nexal lymphoproliferative disease (OALD) was
relatively uncommon diagnosis among caruncu-
lar lesions [1]
OALD was seldom described in Asian popula-
tion especially for young age C-Y Cheng re-
ported age-standardized incidence of ocular
adnexal lymphomas (OAL) in Taiwan from 1979
to 1996 was below 07 per million per year and
mean age was 531 years old [2] In 2015 five
Taiwanese cases of OAL whose age ranging
from 45 to 64 were presented [3] However
there were few cases of conjunctival OAL or
RLH in Chinese pediatric patient
Here we present a case of 16-year-old boy with a
caruncular mass at his left eye with recurrence
one month after excision We describe his clini-
cal symptoms photographs pathological results
management and follow-up clinical course in
this report
CASE REPORT A 16-year-old healthy boy presented a mass
lesion at his left eye caruncle accompanied with
the symptom of tearing for one month (Figure 1)
He had no ocular pain no itchiness no blurred
vision no night sweating no fever and no body
weight loss The patient denied systemic diseas-
es and histories of surgery His bilateral best
corrected visual acuity (BCVA) were 66 and
intraocular pressure (IOP) were both within
normal range There were no remarkable find-
ings for his cornea lens fundus and physical
examination Excision was performed and the
mass was soft with fluid inside therefore con-
junctival pyogenic cyst was our initial diagnosis
However one month after the excision a pro-
truding mass recurred at the patientrsquos nasal can-
thus of left eye (Figure 2) There were some
differences compared to previous condition At
the first time the soft mass was contained in a
well-defined cyst wall which more favored py-
ogenic granulation However after short period
of recurrence solid consistency and unclear
margin were found which favored malignancy
Besides the mass partially involved beyond the
gray line of nasal part lower eyelid whereas last
time the cyst mainly extended from conjunctiva
of caruncle The second excisional biopsy was
performed Pathologic examination demonstrat-
ed abundant atypical lymphoid proliferation
(Figure 3A 3B) Immunohistochemical studies
showed that the lymphoid aggregation was
composed predominantly of CD20-positive cells
(Figure 3C) focal positive staining of CD3
(Figure 3D) CD5 CD23 CD10 and negative
staining of cyclin-D1 Unfortunately the cellular
morphology was difficult to be evaluated due to
marked crushing artifact Thus malignant lym-
phoma cannot be excluded totally
Orbital computed tomography (CT) showed a
lesion of soft tissue density at medial canthus of
left orbit without obvious nasolacrimal duct or
bony invasion (Figure 4A) Magnetic resonance
imaging (MRI) with contrast showed strong
enhancement at left medial canthus region (Fig-
ure 4B) There was no remarkable finding in the
systemic workup including complete blood
count and differential count biochemical pro-
files and 18F-fluoro-2-deoxyglucose positron
emission tomographycomputed tomography
(18F-FDG PETCT) indicating no evidence of
systemic involvement
After the second excision we preferred con-
servative management for him due to the uncer-
tainty of malignancy and to avoid side effects
from aggressive treatment No sign of recurrence
was noted after 10 months of observation The
follow-up photo was taken at three months after
the second operation (Figure 5)
DISCUSSION Ocular adnexal lymphoproliferative disease
(OALD) consists of the spectrum of lymphoid
disease affecting the tissues surrounding the eye
including ocular adnexal lymphomas (OAL) and
lymphoid hyperplasia (LH) [4] The conjunctiva
is an important location for extranodal lympho-
ma development which comprises 25 of OAL
[5]
OAL can be grouped into two categories based
on their appearance of cells under the micro-
scope low-grade and high-grade [6] Extranodal
marginal zone lymphoma of mucosa-associated
lymphoid tissue (EMZLMALT) is the most
common subtype of OAL followed by follicular
lymphoma [7-9] Both of the above are
low-grade lymphomas
LH can be further divided by histopathology into
reactive lymphoid hyperplasia (RLH) and atypi-
cal lymphoid hyperplasia (ALH) RLH has to-
tally benign morphology and immunophenotype
whereas ALH has borderline lesions between
RLH and lymphoma [10] OAL and LH are
mostly seen in patients with age between 50-70
years old There are rare cases in pediatric group
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
114
[71011] In the C-Y Chengrsquos statistical report of
OAL in Taiwan only 8 patients were younger
than 15 years old among the 101 cases of ocular
lymphoma [2] According to an US study inci-
dence rates of OAL were analyzed in different
age groups the group of age over 50 had the
highest incidence rate of 574 per million per-
son-years while the 0-19 age group had the
lowest incidence rate of 009 per million per-
son-years [12] The incidence of LH was even
less than OAL [13]
Patients with OALD may be asymptomatic or
with symptoms of proptosis eyelid swelling a
palpable painless mass or conjunctival salmon
patch Diplopia visual loss pain or inflamma-
tion occurred less frequently implying more
aggressive features [714]
Orbital LH is not distinguishable from low-grade
lymphoma radiologically They both typically
present a round or lobulated mass that diffusely
moderately enhances with contrast and usually
shows homogenous hypointense or isointense to
muscle barely invasion to bone or nervous sys-
tem [10] Atypical appearances including inho-
mogeneous calcification or bony changes may
be seen in high-grade lymphoma case reports
such as ocular adnexal diffuse large B-cell lym-
phoma (DLBCL) which is one of the more ag-
gressive type of OAL [7] Whole body PET is
used for not only the evaluation of systemic
involvement but also the standard for staging
lymphoma Our patientrsquos image studies revealed
neither obvious local invasion nor systemic ma-
lignancy indicating high-grade lymphoma was
less likely Low-grade lymphoma and benign
reactive lymphoid hyperplasia were still under
consideration
Histomorphology analysis and immunohisto-
chemistry (IHC) are essential for diagnosis
Flow cytometry and polymerase chain reaction
(PCR) technique are also applied to help differ-
entiate from RLH and OAL [1016] Our case
had immunohistochemical profile of positivity
for CD20 predominantly positivity focally for
CD3 CD5 CD10 CD23 and negativity for cy-
clin-D1 BCL-6 staining was not performed in
our casersquos biopsy Thus according to the IHC
report RLH ALH and follicular lymphoma are
probable diagnosis of our patient
Radiation therapy is the standard treatment for
low-grade OAL that is classified as T1N0M0 or
T2N0M0 according to the AJCC criteria [15]
İncesoy-Ouml zdemir S et al reported a 10-year-old
boy diagnosed of MALT lymphoma who was
treated with local radiotherapy (36 Gy) and
there were no local or systemic recurrences dur-
ing his nearly four-year follow-up [17] Another
case report represented a 21-year-old man of
conjunctival follicular lymphoma treated with
surgical excision only showing no evidence of
recurrence after 8 months follow-up [18] Other
treatment options for pediatric and juvenile OAL
were performed in some case reports including
intravenous rituximab intralesional interfer-
on-α-2b topical interferon a6 systemic doxycy-
cline surgical excision and postoperative local
cryotherapy [15]
Treatment for young conjunctival RLH was less
discussed in the past In a case series article
three children (9 13 14 years old respectively)
of RLH received surgical resection without fur-
ther postoperative management and no signs of
recurrence were noted during follow-up [19]
Short-term topical and oral corticosteroids after
surgical excision were prescribed in two pediat-
ric RLH patients for their small residual mass
However poor response in both cases was nota-
ble [20]
Our patient declined to receive radiotherapy or
any further postoperative treatment mainly due
to his concerning of possible side effects (such
as dry eye and cataract)
CONCLUSION We present a rare case of caruncle mass in this
report OALD is one of the relatively uncommon
diagnosis among caruncular lesions OALD
includes benign RLH and malignant OAL
which are both mainly seen in elderly patients
even rarer in pediatric or juvenile group
The standard treatment for low-grade OAL and
RLH in young patents are still debatable How-
ever long-term follow-up is suggested for both
OAL and RLH patients Though RLH has a be-
nign and self-limited course risk of malignant
transformation is possible
REFERENCES 1 Levy J Ilsar M Deckel Y et al Lesions of
the caruncle a description of 42 cases and
a review of the literature Eye
200923(5)1004-1018
2 C-Y Cheng and W-M Hsu Incidence of
eye cancer in Taiwan an 18-year review
Eye 200418152-158
3 Chui-Lien Tsen Muh-Chiou Lin
Youn-Shen Bee et al Ocular adnexal
lymphoma Five case reports and a
literature review Taiwan Journal of
Ophthalmology 20155(2)99-102
4 Liesegang TJ Ocular adnexal
lymphoproliferative lesions Mayo Clin
Proc 199368(10)1003-1010
5 Kirkegaard MM Coupland SE Prause JU
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
115
et al Malignant lymphoma of the
conjunctiva Surv Ophthalmol
201560(5)444-458
6 Stacy RC Jakobiec FA Schoenfield L et
al Unifocal and multifocal reactive
lymphoid hyperplasia vs follicular
lymphoma of the ocular adnexa Am J
Ophthalmol 2010150(3)412-426
7 Sullivan TJ Ocular Adnexal
Lymphoproliferative Disease In Guthoff
RF Katowitz JA eds Oculoplastics and
Orbit Berlin Heidelberg Springer
20101-19
8 White Valerie A Understanding and
Classification of Ocular Lymphomas
Ocular Oncology and Pathology
20195379-386
9 Stefanovic A Lossos IS Extranodal
marginal zone lymphoma of the ocular
adnexa Blood 2009114(3)501-510
10 Andrew NH Coupland SE Pirbhai A et al
Lymphoid hyperplasia of the orbit and
ocular adnexa A clinical pathologic review
Surv Ophthalmol 201661(6)778-790
11 Ferry JA1 Fung CY Zukerberg L et al
Lymphoma of the ocular adnexa A study
of 353 cases Am J Surg Pathol
200731(2)170-184
12 WM Hassan MS Bakry HM Hassan et al
Incidence of orbital conjunctival and
lacrimal gland malignant tumors in USA
from Surveillance Epidemiology and End
Results 1973-2009 Int J Ophthalmol
20169(12)1808-1813
13 Ajay A Rao John H Naheedy James Y-Y
Chen et al A Clinical Update and
Radiologic Review of Pediatric Orbital
and Ocular Tumors Journal of Oncology
2013(9)975908
14 Sullivan TJ Whitehead K Williamson R
et al Lymphoproliferative disease of the
ocular adnexa a clinical and pathologic
study with statistical analysis of 69
patients Ophthal Plast Reconstr Surg
200521177-188
15 Tanenbaum RE Galor A Dubovy SR et al
Classification diagnosis and management
of conjunctival lymphoma Eye Vis (Lond)
2019622
16 Olga Klavdianou Georgios Kondylis
Vasileios Georgopoulos et al Bilateral
benign reactive lymphoid hyperplasia of
the conjunctiva a case treated with oral
doxycycline and review of the literature
Eye Vis (Lond) 2019626
17 İncesoy-Ouml zdemir S Yuumlksek N Bozkurt C
et al A rare type of cancer in children
extranodal marginal zone B-cell (MALT)
lymphoma of the ocular adnexa Turk J
Pediatr 201456(3)295-298
18 Lynn J Poole Perry Frederick A Jakobiec
Peter A D Rubin Conjunctival Pediatric
Follicular Lymphoma Arch Ophthalmol
2012130(7)941-943
19 Abdullah Al-Mujaini Upender Wali
Anuradha Ganesh1 et al Ocular Adnexal
Reactive Lymphoid Hyperplasia in
Children Middle East Afr J Ophthalmol
201219(4)406-409
20 McLeod SD Edward DP Benign
lymphoid hyperplasia of the conjunctiva in
children Arch Ophthalmol
1999117(6)832-835
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
116
FIGURES
Figure 1 Slit lamp image of a mass lesion at the patientrsquos left eye caruncle for one month
Figure 2 One month after the first excision a protruding mass recurred at the patientrsquos nasal canthus
of left eye It partially involved beyond the gray line of nasal part lower eyelid
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
117
Figure 3 Histomorphology analysis and immunohistochemistry study of the caruncular lesion Abun-
dant atypical lymphoid proliferation presented in low-power photomicrograph (A) and
high-power photomicrograph (B) under hematoxylin-eosin staining The lymphoid aggrega-
tion was composed predominantly of CD20-positive cells (C) and focal positive staining of
CD3 (D)
Figure 4 Non-contrast orbital computed tomography showed a lesion of soft tissue density at medial
canthus of left orbit without obvious nasolacrimal duct or bony invasion (A) Magnetic reso-
nance imaging with contrast showed strong enhancement at left medial canthus region (B)
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
118
Figure 5 The follow-up photo were taken at three months after the second excision showing no signs
of recurrence
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
119
Juvenile Caruncular Atypical Lymphoid Proliferation ndash A Rare Case Report
罕見病例報告mdash青少年之淚阜非典型淋巴增生
施驊瑋 1林友祺 1
中文摘要
淚阜病灶相當罕見大部分為良性病灶眼睛及附屬結構淋巴增生疾病為其
鑑別診斷之一非常少見於年輕人或兒童我們報告一位 16歲的健康男性因
左眼淚阜無痛性腫塊接受切除手術卻於術後一個月復發執行第二次切除手術
後門診追蹤十個月未再復發此案例表現了部分良性與部分惡性腫瘤的特徵
我們針對反應性淋巴增生眼睛及附屬結構淋巴癌兩個疾病做討論及文獻回顧
關鍵字淚阜病灶眼睛及附屬結構淋巴增生疾病眼睛及附屬結構淋巴癌反
應性淋巴增生非典型淋巴增生
1 新光吳火獅紀念醫院眼科
通訊作者林友祺 電子信箱 yuchi067gmailcom
Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh 120
Submitted March 26 2020
Final version accepted April 16
2020
Case Report
Hyperacute intramembranous hemor-
rhage after burr hole craniostomy for
chronic subdural hematoma
Cite as Meng-Chi Lin Jui-Ming
Sun Yu-Hao Chen Cheng-Ta
Hsieh
Hyperacute intramembranous
hemorrhage after burr hole crani-
ostomy for chronic subdural he-
matoma Fu-Jen Journal of Medi-
cine 3(4) 120-125 2020
DOI
103966181020932020091803004
Meng-Chi Lin1 Jui-Ming Sun23 Yu-Hao Chen24 Cheng-Ta
Hsieh567
1Department of Surgery Zuoying Branch Kaohsiung Armed Forces
General Hospital Kaohsiung 813 Taiwan 2Section of Neurosurgery Department of Surgery Chia-Yi Christian
Hospital Chia-Yi City 600 Taiwan 3Department of Biotechnology Asia University Taichung City 41354
Taiwan 4Chung-Jen Junior College of Nursing Health Sciences and Manage-
ment Chia-Yi Country 62241 Taiwan 5Division of Neurosurgery Department of Surgery Sijhih Cathay Gen-
eral Hospital New Taipei City 22174 Taiwan 6Department of Medicine School of Medicine Fu Jen Catholic Univer-
sity New Taipei City 24205 Taiwan 7Department of Neurological Surgery Tri-Service General Hospital
National Defense Medical Center Taipei 114 Taiwan
Corresponding author E-mail address
nogormail2000comtw (Cheng-Ta Hsieh)
ABSTRACT
Burr hole craniostomy with closed-system drainage is an effective and common neurosurgical procedure to manage chronic subdural hematoma Postoperative hem-orrhage a well-known but infrequent complication may result in increased neurolog-ical deficits However hyperacute intramembranous hemorrhage within the inner and outer membrane of hematoma after burr hole craniostomy with irrigation and closed-system drainage has not been described previously Herein we report a case of postoperative spontaneous hyperacute intramembranous hemorrhage after burr hole craniostomy with closed-system drainage to manage a chronic subdural hematoma we subsequently discuss the possible pathophysiological mechanisms and review the relevant literature
Keywords Chronic subdural hematoma acute subdural hematoma bleeding burr hole craniostomy
drainage
Fu-J
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Vol 3 No 4 2
Acute intram
Yu-Hao Chen
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outer and ievidence suggwith or wite and widely ut and that it ] Recurrence r this surgerywever the hyng after burr ely been discucase of a pa
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ISCUSSIO61-year-old won without regd been takingning Ganodermrs She was tment when shurological exasgow Coma S
muscle strengs was 45 on
ale Her laborh the normal rnoted Brain
n revealed Ch a marked m
ently she receniostomy withinage ring surgery mthe subdural sn of the duramatoma The arile saline throsed drainage swever this inm the subduraealed a hyperdural space fniostomy siteniotomy withthe hematom
morrhage was d inner membgure 3) No aface was obseealed an organn of fibroblasne Postoperaogical deficits
EFERENCRohde VComplicatiand closedsubdural analysis of
active bleedinerved Histolonized hematots and capilla
ative recoverywas gradual a
ON oman had a hi
gular medicatig nutritional ma lucidum referred to ohe became proxamination rScale ratings wgth score in th
the Medical ratory examinranges with nn computed
CSDH in the midline shift (ived one righth irrigation a
motor oilndashlikespace was uncal and outer marea was irrigaough the subdusystem was plcreased the rel space An emracute hemorrfrom the frone (Figure 2B
membranectma was perfo
only observebrane of theactive bleedinerved Histolonized hematots and capilla
ative recoverywas gradual a
CES V Graf Gons of burr-
d-system draihematomas
f 376 patient
ng from the ogical examinoma with prolaries in the m
y of previous and favorable
history of hypeion treatmentsupplements for more tha
our emergencyogressively drrevealed thatwere E1M5V2he left side ex
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(Figure 1) St parietal burrand closed-sy
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dural catheter laced (Figureedness of the mergency brairrhage in the ntal region to
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y of previous and favorable
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Vol 3 No 4 2
Acute intram
Yu-Hao Chen
vealing a layer
displaying a m
quent CT scan
em drainage (
rhage in the ri
2020
membranous
Cheng-Ta Hs
red type of CS
midline shift
ns (A) Bone w
(white arrow)
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ieh
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and (B) Soft
gion (white ar
rrow) in the rig
showed the b
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123
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Fu-J
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g-Chi Lin Ju
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Vol 3 No 4 2
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Yu-Hao Chen
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Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh
125
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
慢性硬腦膜下出血進行鑽顱引流手術造成超急性夾膜內出
血
林孟楫 1孫瑞明 23陳昱豪 24謝政達 567
中文摘要
鑽顱併封閉系統引流手術是治療慢性硬腦膜下出血患者一種有效且常見的
神經外科手術方式術後出血可能導致神經功能缺損惡化是眾所周知但不常見
的併發症之一然而至今仍未有鑽孔併封閉系統引流造成原本慢性硬腦膜血
塊內膜和外膜間急性夾膜間出血案例在這裡我們報告一例慢性硬腦膜下出
血病患者接受鑽顱併封閉系統引流手術治療造成術後急性夾膜間出血我們在
本文中討論可能的致病機制並回顧相關文獻
關鍵字慢性硬腦膜下出血急性硬腦膜下出血出血鑽顱術引流
1國軍高雄總醫院左營分院 外科部
2崇仁醫護管理專科學校
3亞洲大學 生物科技學系
4戴德森醫療財團法人嘉義基督教醫院 外科部 神經外科
5汐止國泰綜合醫院 神經外科
6輔仁大學 醫學系
7 國防醫學院 三軍總醫院 神經外科
通訊作者謝政達 電子信箱 nogormail2000comtw
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
126
Submitted January 21 2020
Final version accepted July 08
2020
Case Report
Hamartoma of the breast A case report
Cite as Hsuan-An Chen
Cheng-Yu Lo Shih-Hung Huang
Chin-Lung Lin
Hamartoma of the breast A case
report Fu-Jen Journal of Medicine
3(5) 126-130 2020
DOI
103966181020932020091803005
Hsuan-An Chen1 Cheng-Yu Lo
3 Shih-Hung Huang
3 Chin-Lung
Lin2
1Department of Surgery Cathay General Hospital Taipei Taiwan
2Department of General Surgery Cathay General Hospital Taipei Tai-
wan
3Department of Pathology Cathay General Hospital Taipei Taiwan
Corresponding author E-mail address
lungyungmailcom (Chin-Lung Lin)
ABSTRACT
Breast hamartoma is an uncommon benign tumor rarely associated with malignancy An
excision and histological examination is necessary for the differential diagnosis We report
a case of a 49-year-old female patient presenting with a lump in the right breast Ultrasound
examination which demonstrated a 4411 cm hypoechoic lesion with lipoma Partial mas-
tectomy was arranged and the diagnosis of a hamartoma was confirmed by the histological
examination
Keywords Breast tumor Hamartoma Ultrasound
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
127
INTRODUCTION The hamartoma is a benign tumor-like lesion
that can affect various organs of the body in-
cluding lungs kidneys skin and more rarely the
breast In 1981 the hamartomas were recognized
in the WHO classification[1] They are defined
as well-demarcated mass of mammary ducts and
lobules containing varying amounts of fibrous
and adipose tissue and producing a distinctive
mammographic image
CASE REPORT A 49 year-old female had past history of left
breast mastitis with abscess status post partial
mastectomy This time she presented to our out
patient clinic for breast examination Physical
examination revealed a painless palpable mova-
ble and painless lump at upper outer quadrant of
right breast The risk of breast cancer was not
noted and the patient did not have any family
history of breast cancer The patient also denied
any trauma history before Ultrasound examina-
tion was arranged which demonstrated a 4411
cm hypoechoic lesion with lipoma at 3 oclock 2
cm from nipple of right breast and multiple hy-
poechoic nodules of various size in both breasts
and there was no suspicious axillary lymph
nodes noted (Figure1) Surgical treatment was
arranged partial mastectomy of right breast
harmartoma was successfully performed A 32 x
31 x 21 cm tumor was completely excised
Grossly examination showed a gray to yellow
and firm to fatty The diagnosis of a hamartoma
was confirmed by the histological examination
Microscopically sections of the breast lesion
show mammary hamartoma composed of ducts
lobules with interlobular fibrous tissue and adi-
pose tissue Fibrocystic change apocrine meta-
plastic ducts and scattered foci of adenosis are
noted The overall lobulocentric architecture and
the 2-cell pattern of the epithelium are preserved
columnar cell change and focal microcalcifica-
tion are present (Figure2) Based on submitted
biopsy specimen in-situ or invasive tumor cells
are not identified
DISCUSSION Hamartoma of the breast is a benign tumor like
nodule it was also known as fibroadenolipoma
lipofibroadenoma or adenolipoma based on its
predominant components It was composed of
varying amounts of glandular adipose and fi-
brous tissue[2] Hamartomas were first described
in 1971 by Arrigoni et al in a study of 10 patients
which breast tumors clinically and grossly re-
sembled fibroadenomas[3]
A higher predominance of tumors exists in fe-
males compared with males Hamartomas are
slowly-growing lesions with the diameter rang-
ing from 2 cm to 5 cm sometimes hamartomas
can reach giant diameter [4]
The clinical diagnosis of hamartoma is based on
the findings from mammography sonography
and histology examinations The hamartomas are
usually incidentally diagnosed by the women
older than 40 year-old starting mammography
screening
On physicial examination harmatomas are usu-
ally occult painless they may be as large mo-
bile soft to firm masses[5] Ultrasound showed
well capsulated mass with echogenic rim and
internal heterogeneity Mammography exam
showed well-circumscribed round to oval
masses containing fat and soft tissue densities
with a thin radiopaque pseudocapsule The
pseudocapsule results from displacement of
breast parenchyma by the tumor [56] In Pa-
thology finding microglandular adenosis is pre-
sent in fibroadipose stroma surrounded by a thin
fibrous capsule It composed of a combination of
epithelial and stromal elements usually with
normal ducts or lobules although variations of
normal tissue may also be seen Fibroadenoli-
poma myoid hamartoma and chondrolipoma are
histological variations of hamartomas depend-
ing on the proportion of normal breast tissue
elements[7]
Malignancy associated with hamartomas are
very rare[8] However it has been reported
hamartomas develop into carcinoma Malignant
transformation can occur as a result of cellular
atypia in the epithelial component of the mass[9]
Surgical removal is the curative method for
breast hamartomas[10] Diagnostic material such
as mammography ultrasonography or core nee-
dle biopsy may not give the definitive diagnosis
Therefore surgical excision and histological
examination is necessary for differential diagno-
sis[111213]
Although it is rare hamartoma can be seen along
with malignancy as it is formed from similar
components of breast tissue Therefore careful
diagnosis and appropriate management including
surgery are required
REFERENCES 1 World Health Organization (1981)
Histological typing of breast tumors In
International histological classification of
tumors 1981 2nd ed
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
128
2 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11435ndash449
2006
3 ArrigoniMG DockertyMB JuddES
The identificationand treatment of
mammary hamartoma Surg Gynecol
Obstet1971 133 577-82
4 Sanal HT Ersoz N Altinel O Unal E Can
C Giant hamartoma of the breast Breast J
2006 12 84-85
5 Feder JM de Paredes ES Hogge JP
Wilken JJ Unusual breast lesions
radiologic-pathologic correlation
Radiographics 1999 19S11ndashS26
6 Murat A Ozdemir H Yildirim H Poyraz
AK Ozercan R Hamartoma of the breast
Australas Radiol 200751 Spec NoB37ndash
9
7 Fisher CJ Hanby AM Robinson L Millis
RR Mammary hamartoma-a review of 35
cases Histopathology 1992 20 99-106
8 Choi N Ko ES Invasive ductal carcinoma
in a mammary hamartoma case report and
review of the literature Korean J Radiol
2010 Nov-Dec11(6)687-91
9 Lee EH Wylie EJ Bourke AG Bastiaan
De Boer W Invasive ductal carcinoma
arising in a breast hamartoma two case
reports and a review of the literature Clin
Radiol 2003 58 80-3
10 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11 435 ‑449
2006
11 Coyne J Hobbs FM Boggis C Harland R
Lobular carcinoma in a mammary
hamartoma J Clin Pathol 199245936ndash
937
12 G M K Tse B K B Law T K F Ma A B W
Chan Hamartoma of the breast a
clinicopathological review J Clin Pathol
200255951ndash954
13 RAAmir SSheikh BreasthamartomaA
report of 14cases of an under-recognized
and under-reported entity International
Journal of Surgery Case Reports
22(2016)1ndash4
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
129
FIGURES
Figure 1 Ultrasound shows a 4411 cm hypoechoic lesion with lipoma at 3 oclock 2 cm from nipple
of right breast
Figure 2 Photomicrograph shows mammary hamartoma composed of ducts lobules with interlobular
fibrous tissue and adipose tissue
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
130
Hamartoma of the breast A case report
乳房錯構瘤罕見個案報告
陳宣安 1羅承裕 3黃世鴻 3林錦龍 2
中文摘要
乳房錯構瘤是一種罕見之乳房良性腫瘤切除手術及病理化驗來做鑑別診斷
我們報告一位 49歲女性以可觸摸到無痛性右側乳房腫塊為臨床表徵超音波
看到一個邊緣清楚低迴音的腫塊病患接受手術切除病灶病理診斷證實為乳
房錯構瘤
關鍵字乳房腫瘤錯構瘤超音波攝影
1國泰綜合醫院外科部
2國泰綜合醫院一般外科
3國泰綜合醫院病理科
通訊作者林錦龍 電子信箱 lungyungmailcom
Fu-Jen Journal of Medicine
Mission and Goals
The Fu-Jen Journal of Medicine (FJJM) is a peer-reviewed journal which
aims to enhance research quality of staffs in the College of Medicine Fu Jen
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Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin 112
Submitted January 20 2020
Final version accepted April13
2020
Case Report
Juvenile Caruncular Atypical Lymphoid
Proliferation ndash A Rare Case Report
Cite as Hua-Wei Shih Yu-Chi Lin
Juvenile Caruncular Atypical
Lymphoid Proliferation ndash A Rare
Case Report Fu-Jen Journal of
Medicine 3(3) 112-119 2020
DOI
103966181020932020091803003
Hua-Wei Shih1 Yu-Chi Lin
1
1Department of Ophthalmology Shin Kong Wu Ho-Su Memorial Hos-
pital Taipei City Taiwan
Corresponding author E-mail address
yuchi067gmailcom (Yu-Chi Lin)
ABSTRACT
Lesions of the caruncle are very rare Most caruncular lesions are benign though there were still few reported malignant lesions Ocular adnexal lymphoproliferative disease (OALD) one of the differential diagnosis of caruncular lesion is seldom seen in young pa-tient In this article we report a 16-year-old boy with recurrent caruncular atypical lym-phoid proliferation We discuss the epidemiology clinical features images histomorpholo-gy and treatment between ocular adnexal lymphomas (OAL) and reactive lymphoid hyper-plasia (RLH)
Keywords caruncular lesion ocular adnexal lymphoproliferative disease ocular adnexal lymphoma
reactive lymphoid hyperplasia atypical lymphoid proliferation
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
113
INTRODUCTION Lesions of the caruncle are very rare Differen-
tial diagnosis includes nevus myeloproliferative
disorders tumors inflammation infection cysts
vascular lesions and fibrous Biopsy is essential
for diagnosis Levy J et al reported ocular ad-
nexal lymphoproliferative disease (OALD) was
relatively uncommon diagnosis among caruncu-
lar lesions [1]
OALD was seldom described in Asian popula-
tion especially for young age C-Y Cheng re-
ported age-standardized incidence of ocular
adnexal lymphomas (OAL) in Taiwan from 1979
to 1996 was below 07 per million per year and
mean age was 531 years old [2] In 2015 five
Taiwanese cases of OAL whose age ranging
from 45 to 64 were presented [3] However
there were few cases of conjunctival OAL or
RLH in Chinese pediatric patient
Here we present a case of 16-year-old boy with a
caruncular mass at his left eye with recurrence
one month after excision We describe his clini-
cal symptoms photographs pathological results
management and follow-up clinical course in
this report
CASE REPORT A 16-year-old healthy boy presented a mass
lesion at his left eye caruncle accompanied with
the symptom of tearing for one month (Figure 1)
He had no ocular pain no itchiness no blurred
vision no night sweating no fever and no body
weight loss The patient denied systemic diseas-
es and histories of surgery His bilateral best
corrected visual acuity (BCVA) were 66 and
intraocular pressure (IOP) were both within
normal range There were no remarkable find-
ings for his cornea lens fundus and physical
examination Excision was performed and the
mass was soft with fluid inside therefore con-
junctival pyogenic cyst was our initial diagnosis
However one month after the excision a pro-
truding mass recurred at the patientrsquos nasal can-
thus of left eye (Figure 2) There were some
differences compared to previous condition At
the first time the soft mass was contained in a
well-defined cyst wall which more favored py-
ogenic granulation However after short period
of recurrence solid consistency and unclear
margin were found which favored malignancy
Besides the mass partially involved beyond the
gray line of nasal part lower eyelid whereas last
time the cyst mainly extended from conjunctiva
of caruncle The second excisional biopsy was
performed Pathologic examination demonstrat-
ed abundant atypical lymphoid proliferation
(Figure 3A 3B) Immunohistochemical studies
showed that the lymphoid aggregation was
composed predominantly of CD20-positive cells
(Figure 3C) focal positive staining of CD3
(Figure 3D) CD5 CD23 CD10 and negative
staining of cyclin-D1 Unfortunately the cellular
morphology was difficult to be evaluated due to
marked crushing artifact Thus malignant lym-
phoma cannot be excluded totally
Orbital computed tomography (CT) showed a
lesion of soft tissue density at medial canthus of
left orbit without obvious nasolacrimal duct or
bony invasion (Figure 4A) Magnetic resonance
imaging (MRI) with contrast showed strong
enhancement at left medial canthus region (Fig-
ure 4B) There was no remarkable finding in the
systemic workup including complete blood
count and differential count biochemical pro-
files and 18F-fluoro-2-deoxyglucose positron
emission tomographycomputed tomography
(18F-FDG PETCT) indicating no evidence of
systemic involvement
After the second excision we preferred con-
servative management for him due to the uncer-
tainty of malignancy and to avoid side effects
from aggressive treatment No sign of recurrence
was noted after 10 months of observation The
follow-up photo was taken at three months after
the second operation (Figure 5)
DISCUSSION Ocular adnexal lymphoproliferative disease
(OALD) consists of the spectrum of lymphoid
disease affecting the tissues surrounding the eye
including ocular adnexal lymphomas (OAL) and
lymphoid hyperplasia (LH) [4] The conjunctiva
is an important location for extranodal lympho-
ma development which comprises 25 of OAL
[5]
OAL can be grouped into two categories based
on their appearance of cells under the micro-
scope low-grade and high-grade [6] Extranodal
marginal zone lymphoma of mucosa-associated
lymphoid tissue (EMZLMALT) is the most
common subtype of OAL followed by follicular
lymphoma [7-9] Both of the above are
low-grade lymphomas
LH can be further divided by histopathology into
reactive lymphoid hyperplasia (RLH) and atypi-
cal lymphoid hyperplasia (ALH) RLH has to-
tally benign morphology and immunophenotype
whereas ALH has borderline lesions between
RLH and lymphoma [10] OAL and LH are
mostly seen in patients with age between 50-70
years old There are rare cases in pediatric group
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
114
[71011] In the C-Y Chengrsquos statistical report of
OAL in Taiwan only 8 patients were younger
than 15 years old among the 101 cases of ocular
lymphoma [2] According to an US study inci-
dence rates of OAL were analyzed in different
age groups the group of age over 50 had the
highest incidence rate of 574 per million per-
son-years while the 0-19 age group had the
lowest incidence rate of 009 per million per-
son-years [12] The incidence of LH was even
less than OAL [13]
Patients with OALD may be asymptomatic or
with symptoms of proptosis eyelid swelling a
palpable painless mass or conjunctival salmon
patch Diplopia visual loss pain or inflamma-
tion occurred less frequently implying more
aggressive features [714]
Orbital LH is not distinguishable from low-grade
lymphoma radiologically They both typically
present a round or lobulated mass that diffusely
moderately enhances with contrast and usually
shows homogenous hypointense or isointense to
muscle barely invasion to bone or nervous sys-
tem [10] Atypical appearances including inho-
mogeneous calcification or bony changes may
be seen in high-grade lymphoma case reports
such as ocular adnexal diffuse large B-cell lym-
phoma (DLBCL) which is one of the more ag-
gressive type of OAL [7] Whole body PET is
used for not only the evaluation of systemic
involvement but also the standard for staging
lymphoma Our patientrsquos image studies revealed
neither obvious local invasion nor systemic ma-
lignancy indicating high-grade lymphoma was
less likely Low-grade lymphoma and benign
reactive lymphoid hyperplasia were still under
consideration
Histomorphology analysis and immunohisto-
chemistry (IHC) are essential for diagnosis
Flow cytometry and polymerase chain reaction
(PCR) technique are also applied to help differ-
entiate from RLH and OAL [1016] Our case
had immunohistochemical profile of positivity
for CD20 predominantly positivity focally for
CD3 CD5 CD10 CD23 and negativity for cy-
clin-D1 BCL-6 staining was not performed in
our casersquos biopsy Thus according to the IHC
report RLH ALH and follicular lymphoma are
probable diagnosis of our patient
Radiation therapy is the standard treatment for
low-grade OAL that is classified as T1N0M0 or
T2N0M0 according to the AJCC criteria [15]
İncesoy-Ouml zdemir S et al reported a 10-year-old
boy diagnosed of MALT lymphoma who was
treated with local radiotherapy (36 Gy) and
there were no local or systemic recurrences dur-
ing his nearly four-year follow-up [17] Another
case report represented a 21-year-old man of
conjunctival follicular lymphoma treated with
surgical excision only showing no evidence of
recurrence after 8 months follow-up [18] Other
treatment options for pediatric and juvenile OAL
were performed in some case reports including
intravenous rituximab intralesional interfer-
on-α-2b topical interferon a6 systemic doxycy-
cline surgical excision and postoperative local
cryotherapy [15]
Treatment for young conjunctival RLH was less
discussed in the past In a case series article
three children (9 13 14 years old respectively)
of RLH received surgical resection without fur-
ther postoperative management and no signs of
recurrence were noted during follow-up [19]
Short-term topical and oral corticosteroids after
surgical excision were prescribed in two pediat-
ric RLH patients for their small residual mass
However poor response in both cases was nota-
ble [20]
Our patient declined to receive radiotherapy or
any further postoperative treatment mainly due
to his concerning of possible side effects (such
as dry eye and cataract)
CONCLUSION We present a rare case of caruncle mass in this
report OALD is one of the relatively uncommon
diagnosis among caruncular lesions OALD
includes benign RLH and malignant OAL
which are both mainly seen in elderly patients
even rarer in pediatric or juvenile group
The standard treatment for low-grade OAL and
RLH in young patents are still debatable How-
ever long-term follow-up is suggested for both
OAL and RLH patients Though RLH has a be-
nign and self-limited course risk of malignant
transformation is possible
REFERENCES 1 Levy J Ilsar M Deckel Y et al Lesions of
the caruncle a description of 42 cases and
a review of the literature Eye
200923(5)1004-1018
2 C-Y Cheng and W-M Hsu Incidence of
eye cancer in Taiwan an 18-year review
Eye 200418152-158
3 Chui-Lien Tsen Muh-Chiou Lin
Youn-Shen Bee et al Ocular adnexal
lymphoma Five case reports and a
literature review Taiwan Journal of
Ophthalmology 20155(2)99-102
4 Liesegang TJ Ocular adnexal
lymphoproliferative lesions Mayo Clin
Proc 199368(10)1003-1010
5 Kirkegaard MM Coupland SE Prause JU
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
115
et al Malignant lymphoma of the
conjunctiva Surv Ophthalmol
201560(5)444-458
6 Stacy RC Jakobiec FA Schoenfield L et
al Unifocal and multifocal reactive
lymphoid hyperplasia vs follicular
lymphoma of the ocular adnexa Am J
Ophthalmol 2010150(3)412-426
7 Sullivan TJ Ocular Adnexal
Lymphoproliferative Disease In Guthoff
RF Katowitz JA eds Oculoplastics and
Orbit Berlin Heidelberg Springer
20101-19
8 White Valerie A Understanding and
Classification of Ocular Lymphomas
Ocular Oncology and Pathology
20195379-386
9 Stefanovic A Lossos IS Extranodal
marginal zone lymphoma of the ocular
adnexa Blood 2009114(3)501-510
10 Andrew NH Coupland SE Pirbhai A et al
Lymphoid hyperplasia of the orbit and
ocular adnexa A clinical pathologic review
Surv Ophthalmol 201661(6)778-790
11 Ferry JA1 Fung CY Zukerberg L et al
Lymphoma of the ocular adnexa A study
of 353 cases Am J Surg Pathol
200731(2)170-184
12 WM Hassan MS Bakry HM Hassan et al
Incidence of orbital conjunctival and
lacrimal gland malignant tumors in USA
from Surveillance Epidemiology and End
Results 1973-2009 Int J Ophthalmol
20169(12)1808-1813
13 Ajay A Rao John H Naheedy James Y-Y
Chen et al A Clinical Update and
Radiologic Review of Pediatric Orbital
and Ocular Tumors Journal of Oncology
2013(9)975908
14 Sullivan TJ Whitehead K Williamson R
et al Lymphoproliferative disease of the
ocular adnexa a clinical and pathologic
study with statistical analysis of 69
patients Ophthal Plast Reconstr Surg
200521177-188
15 Tanenbaum RE Galor A Dubovy SR et al
Classification diagnosis and management
of conjunctival lymphoma Eye Vis (Lond)
2019622
16 Olga Klavdianou Georgios Kondylis
Vasileios Georgopoulos et al Bilateral
benign reactive lymphoid hyperplasia of
the conjunctiva a case treated with oral
doxycycline and review of the literature
Eye Vis (Lond) 2019626
17 İncesoy-Ouml zdemir S Yuumlksek N Bozkurt C
et al A rare type of cancer in children
extranodal marginal zone B-cell (MALT)
lymphoma of the ocular adnexa Turk J
Pediatr 201456(3)295-298
18 Lynn J Poole Perry Frederick A Jakobiec
Peter A D Rubin Conjunctival Pediatric
Follicular Lymphoma Arch Ophthalmol
2012130(7)941-943
19 Abdullah Al-Mujaini Upender Wali
Anuradha Ganesh1 et al Ocular Adnexal
Reactive Lymphoid Hyperplasia in
Children Middle East Afr J Ophthalmol
201219(4)406-409
20 McLeod SD Edward DP Benign
lymphoid hyperplasia of the conjunctiva in
children Arch Ophthalmol
1999117(6)832-835
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
116
FIGURES
Figure 1 Slit lamp image of a mass lesion at the patientrsquos left eye caruncle for one month
Figure 2 One month after the first excision a protruding mass recurred at the patientrsquos nasal canthus
of left eye It partially involved beyond the gray line of nasal part lower eyelid
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
117
Figure 3 Histomorphology analysis and immunohistochemistry study of the caruncular lesion Abun-
dant atypical lymphoid proliferation presented in low-power photomicrograph (A) and
high-power photomicrograph (B) under hematoxylin-eosin staining The lymphoid aggrega-
tion was composed predominantly of CD20-positive cells (C) and focal positive staining of
CD3 (D)
Figure 4 Non-contrast orbital computed tomography showed a lesion of soft tissue density at medial
canthus of left orbit without obvious nasolacrimal duct or bony invasion (A) Magnetic reso-
nance imaging with contrast showed strong enhancement at left medial canthus region (B)
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
118
Figure 5 The follow-up photo were taken at three months after the second excision showing no signs
of recurrence
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
119
Juvenile Caruncular Atypical Lymphoid Proliferation ndash A Rare Case Report
罕見病例報告mdash青少年之淚阜非典型淋巴增生
施驊瑋 1林友祺 1
中文摘要
淚阜病灶相當罕見大部分為良性病灶眼睛及附屬結構淋巴增生疾病為其
鑑別診斷之一非常少見於年輕人或兒童我們報告一位 16歲的健康男性因
左眼淚阜無痛性腫塊接受切除手術卻於術後一個月復發執行第二次切除手術
後門診追蹤十個月未再復發此案例表現了部分良性與部分惡性腫瘤的特徵
我們針對反應性淋巴增生眼睛及附屬結構淋巴癌兩個疾病做討論及文獻回顧
關鍵字淚阜病灶眼睛及附屬結構淋巴增生疾病眼睛及附屬結構淋巴癌反
應性淋巴增生非典型淋巴增生
1 新光吳火獅紀念醫院眼科
通訊作者林友祺 電子信箱 yuchi067gmailcom
Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh 120
Submitted March 26 2020
Final version accepted April 16
2020
Case Report
Hyperacute intramembranous hemor-
rhage after burr hole craniostomy for
chronic subdural hematoma
Cite as Meng-Chi Lin Jui-Ming
Sun Yu-Hao Chen Cheng-Ta
Hsieh
Hyperacute intramembranous
hemorrhage after burr hole crani-
ostomy for chronic subdural he-
matoma Fu-Jen Journal of Medi-
cine 3(4) 120-125 2020
DOI
103966181020932020091803004
Meng-Chi Lin1 Jui-Ming Sun23 Yu-Hao Chen24 Cheng-Ta
Hsieh567
1Department of Surgery Zuoying Branch Kaohsiung Armed Forces
General Hospital Kaohsiung 813 Taiwan 2Section of Neurosurgery Department of Surgery Chia-Yi Christian
Hospital Chia-Yi City 600 Taiwan 3Department of Biotechnology Asia University Taichung City 41354
Taiwan 4Chung-Jen Junior College of Nursing Health Sciences and Manage-
ment Chia-Yi Country 62241 Taiwan 5Division of Neurosurgery Department of Surgery Sijhih Cathay Gen-
eral Hospital New Taipei City 22174 Taiwan 6Department of Medicine School of Medicine Fu Jen Catholic Univer-
sity New Taipei City 24205 Taiwan 7Department of Neurological Surgery Tri-Service General Hospital
National Defense Medical Center Taipei 114 Taiwan
Corresponding author E-mail address
nogormail2000comtw (Cheng-Ta Hsieh)
ABSTRACT
Burr hole craniostomy with closed-system drainage is an effective and common neurosurgical procedure to manage chronic subdural hematoma Postoperative hem-orrhage a well-known but infrequent complication may result in increased neurolog-ical deficits However hyperacute intramembranous hemorrhage within the inner and outer membrane of hematoma after burr hole craniostomy with irrigation and closed-system drainage has not been described previously Herein we report a case of postoperative spontaneous hyperacute intramembranous hemorrhage after burr hole craniostomy with closed-system drainage to manage a chronic subdural hematoma we subsequently discuss the possible pathophysiological mechanisms and review the relevant literature
Keywords Chronic subdural hematoma acute subdural hematoma bleeding burr hole craniostomy
drainage
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Vol 3 No 4 2
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Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh
125
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
慢性硬腦膜下出血進行鑽顱引流手術造成超急性夾膜內出
血
林孟楫 1孫瑞明 23陳昱豪 24謝政達 567
中文摘要
鑽顱併封閉系統引流手術是治療慢性硬腦膜下出血患者一種有效且常見的
神經外科手術方式術後出血可能導致神經功能缺損惡化是眾所周知但不常見
的併發症之一然而至今仍未有鑽孔併封閉系統引流造成原本慢性硬腦膜血
塊內膜和外膜間急性夾膜間出血案例在這裡我們報告一例慢性硬腦膜下出
血病患者接受鑽顱併封閉系統引流手術治療造成術後急性夾膜間出血我們在
本文中討論可能的致病機制並回顧相關文獻
關鍵字慢性硬腦膜下出血急性硬腦膜下出血出血鑽顱術引流
1國軍高雄總醫院左營分院 外科部
2崇仁醫護管理專科學校
3亞洲大學 生物科技學系
4戴德森醫療財團法人嘉義基督教醫院 外科部 神經外科
5汐止國泰綜合醫院 神經外科
6輔仁大學 醫學系
7 國防醫學院 三軍總醫院 神經外科
通訊作者謝政達 電子信箱 nogormail2000comtw
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
126
Submitted January 21 2020
Final version accepted July 08
2020
Case Report
Hamartoma of the breast A case report
Cite as Hsuan-An Chen
Cheng-Yu Lo Shih-Hung Huang
Chin-Lung Lin
Hamartoma of the breast A case
report Fu-Jen Journal of Medicine
3(5) 126-130 2020
DOI
103966181020932020091803005
Hsuan-An Chen1 Cheng-Yu Lo
3 Shih-Hung Huang
3 Chin-Lung
Lin2
1Department of Surgery Cathay General Hospital Taipei Taiwan
2Department of General Surgery Cathay General Hospital Taipei Tai-
wan
3Department of Pathology Cathay General Hospital Taipei Taiwan
Corresponding author E-mail address
lungyungmailcom (Chin-Lung Lin)
ABSTRACT
Breast hamartoma is an uncommon benign tumor rarely associated with malignancy An
excision and histological examination is necessary for the differential diagnosis We report
a case of a 49-year-old female patient presenting with a lump in the right breast Ultrasound
examination which demonstrated a 4411 cm hypoechoic lesion with lipoma Partial mas-
tectomy was arranged and the diagnosis of a hamartoma was confirmed by the histological
examination
Keywords Breast tumor Hamartoma Ultrasound
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
127
INTRODUCTION The hamartoma is a benign tumor-like lesion
that can affect various organs of the body in-
cluding lungs kidneys skin and more rarely the
breast In 1981 the hamartomas were recognized
in the WHO classification[1] They are defined
as well-demarcated mass of mammary ducts and
lobules containing varying amounts of fibrous
and adipose tissue and producing a distinctive
mammographic image
CASE REPORT A 49 year-old female had past history of left
breast mastitis with abscess status post partial
mastectomy This time she presented to our out
patient clinic for breast examination Physical
examination revealed a painless palpable mova-
ble and painless lump at upper outer quadrant of
right breast The risk of breast cancer was not
noted and the patient did not have any family
history of breast cancer The patient also denied
any trauma history before Ultrasound examina-
tion was arranged which demonstrated a 4411
cm hypoechoic lesion with lipoma at 3 oclock 2
cm from nipple of right breast and multiple hy-
poechoic nodules of various size in both breasts
and there was no suspicious axillary lymph
nodes noted (Figure1) Surgical treatment was
arranged partial mastectomy of right breast
harmartoma was successfully performed A 32 x
31 x 21 cm tumor was completely excised
Grossly examination showed a gray to yellow
and firm to fatty The diagnosis of a hamartoma
was confirmed by the histological examination
Microscopically sections of the breast lesion
show mammary hamartoma composed of ducts
lobules with interlobular fibrous tissue and adi-
pose tissue Fibrocystic change apocrine meta-
plastic ducts and scattered foci of adenosis are
noted The overall lobulocentric architecture and
the 2-cell pattern of the epithelium are preserved
columnar cell change and focal microcalcifica-
tion are present (Figure2) Based on submitted
biopsy specimen in-situ or invasive tumor cells
are not identified
DISCUSSION Hamartoma of the breast is a benign tumor like
nodule it was also known as fibroadenolipoma
lipofibroadenoma or adenolipoma based on its
predominant components It was composed of
varying amounts of glandular adipose and fi-
brous tissue[2] Hamartomas were first described
in 1971 by Arrigoni et al in a study of 10 patients
which breast tumors clinically and grossly re-
sembled fibroadenomas[3]
A higher predominance of tumors exists in fe-
males compared with males Hamartomas are
slowly-growing lesions with the diameter rang-
ing from 2 cm to 5 cm sometimes hamartomas
can reach giant diameter [4]
The clinical diagnosis of hamartoma is based on
the findings from mammography sonography
and histology examinations The hamartomas are
usually incidentally diagnosed by the women
older than 40 year-old starting mammography
screening
On physicial examination harmatomas are usu-
ally occult painless they may be as large mo-
bile soft to firm masses[5] Ultrasound showed
well capsulated mass with echogenic rim and
internal heterogeneity Mammography exam
showed well-circumscribed round to oval
masses containing fat and soft tissue densities
with a thin radiopaque pseudocapsule The
pseudocapsule results from displacement of
breast parenchyma by the tumor [56] In Pa-
thology finding microglandular adenosis is pre-
sent in fibroadipose stroma surrounded by a thin
fibrous capsule It composed of a combination of
epithelial and stromal elements usually with
normal ducts or lobules although variations of
normal tissue may also be seen Fibroadenoli-
poma myoid hamartoma and chondrolipoma are
histological variations of hamartomas depend-
ing on the proportion of normal breast tissue
elements[7]
Malignancy associated with hamartomas are
very rare[8] However it has been reported
hamartomas develop into carcinoma Malignant
transformation can occur as a result of cellular
atypia in the epithelial component of the mass[9]
Surgical removal is the curative method for
breast hamartomas[10] Diagnostic material such
as mammography ultrasonography or core nee-
dle biopsy may not give the definitive diagnosis
Therefore surgical excision and histological
examination is necessary for differential diagno-
sis[111213]
Although it is rare hamartoma can be seen along
with malignancy as it is formed from similar
components of breast tissue Therefore careful
diagnosis and appropriate management including
surgery are required
REFERENCES 1 World Health Organization (1981)
Histological typing of breast tumors In
International histological classification of
tumors 1981 2nd ed
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
128
2 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11435ndash449
2006
3 ArrigoniMG DockertyMB JuddES
The identificationand treatment of
mammary hamartoma Surg Gynecol
Obstet1971 133 577-82
4 Sanal HT Ersoz N Altinel O Unal E Can
C Giant hamartoma of the breast Breast J
2006 12 84-85
5 Feder JM de Paredes ES Hogge JP
Wilken JJ Unusual breast lesions
radiologic-pathologic correlation
Radiographics 1999 19S11ndashS26
6 Murat A Ozdemir H Yildirim H Poyraz
AK Ozercan R Hamartoma of the breast
Australas Radiol 200751 Spec NoB37ndash
9
7 Fisher CJ Hanby AM Robinson L Millis
RR Mammary hamartoma-a review of 35
cases Histopathology 1992 20 99-106
8 Choi N Ko ES Invasive ductal carcinoma
in a mammary hamartoma case report and
review of the literature Korean J Radiol
2010 Nov-Dec11(6)687-91
9 Lee EH Wylie EJ Bourke AG Bastiaan
De Boer W Invasive ductal carcinoma
arising in a breast hamartoma two case
reports and a review of the literature Clin
Radiol 2003 58 80-3
10 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11 435 ‑449
2006
11 Coyne J Hobbs FM Boggis C Harland R
Lobular carcinoma in a mammary
hamartoma J Clin Pathol 199245936ndash
937
12 G M K Tse B K B Law T K F Ma A B W
Chan Hamartoma of the breast a
clinicopathological review J Clin Pathol
200255951ndash954
13 RAAmir SSheikh BreasthamartomaA
report of 14cases of an under-recognized
and under-reported entity International
Journal of Surgery Case Reports
22(2016)1ndash4
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
129
FIGURES
Figure 1 Ultrasound shows a 4411 cm hypoechoic lesion with lipoma at 3 oclock 2 cm from nipple
of right breast
Figure 2 Photomicrograph shows mammary hamartoma composed of ducts lobules with interlobular
fibrous tissue and adipose tissue
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
130
Hamartoma of the breast A case report
乳房錯構瘤罕見個案報告
陳宣安 1羅承裕 3黃世鴻 3林錦龍 2
中文摘要
乳房錯構瘤是一種罕見之乳房良性腫瘤切除手術及病理化驗來做鑑別診斷
我們報告一位 49歲女性以可觸摸到無痛性右側乳房腫塊為臨床表徵超音波
看到一個邊緣清楚低迴音的腫塊病患接受手術切除病灶病理診斷證實為乳
房錯構瘤
關鍵字乳房腫瘤錯構瘤超音波攝影
1國泰綜合醫院外科部
2國泰綜合醫院一般外科
3國泰綜合醫院病理科
通訊作者林錦龍 電子信箱 lungyungmailcom
Fu-Jen Journal of Medicine
Mission and Goals
The Fu-Jen Journal of Medicine (FJJM) is a peer-reviewed journal which
aims to enhance research quality of staffs in the College of Medicine Fu Jen
Catholic University The journal publishes original investigations across a
wide range of medical disciplines including original research articles in basic
and clinical sciences case reports review articles brief reports and letter
to the editor FJJM is now issued by the Center of Medical Education in the
College of Medicine Fu Jen Catholic University To promote journal quality
the manuscript submitted to FJJM after August first 2015 has to be prepared
in English to meet the international standards
Issue Date
Publication Date
Institution
December 01 2003
September 30 2020
College of Medicine Fu Jen Catholic University
Honorable publisher Han-Sun Chiang
Publisher Ping-Keung Yip
Editor-in-chief Ming-Chieh Ma
Associate Editors Yu-Wen Lin
Editors
Telephone (02) 2905-3477
Address Center for Medical Education College of Medicine Fu Jen
Catholic University
No 510 Zhongzheng Rd Xinzhuang Dist New Taipei City
24205 Taiwan
Su-Jane Wang Chi-Chung Wang Chih-Ming Ho
Yih-Jing Lee Chih-Shung Wong Tze-Wah Kao
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- 9月封面
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Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
113
INTRODUCTION Lesions of the caruncle are very rare Differen-
tial diagnosis includes nevus myeloproliferative
disorders tumors inflammation infection cysts
vascular lesions and fibrous Biopsy is essential
for diagnosis Levy J et al reported ocular ad-
nexal lymphoproliferative disease (OALD) was
relatively uncommon diagnosis among caruncu-
lar lesions [1]
OALD was seldom described in Asian popula-
tion especially for young age C-Y Cheng re-
ported age-standardized incidence of ocular
adnexal lymphomas (OAL) in Taiwan from 1979
to 1996 was below 07 per million per year and
mean age was 531 years old [2] In 2015 five
Taiwanese cases of OAL whose age ranging
from 45 to 64 were presented [3] However
there were few cases of conjunctival OAL or
RLH in Chinese pediatric patient
Here we present a case of 16-year-old boy with a
caruncular mass at his left eye with recurrence
one month after excision We describe his clini-
cal symptoms photographs pathological results
management and follow-up clinical course in
this report
CASE REPORT A 16-year-old healthy boy presented a mass
lesion at his left eye caruncle accompanied with
the symptom of tearing for one month (Figure 1)
He had no ocular pain no itchiness no blurred
vision no night sweating no fever and no body
weight loss The patient denied systemic diseas-
es and histories of surgery His bilateral best
corrected visual acuity (BCVA) were 66 and
intraocular pressure (IOP) were both within
normal range There were no remarkable find-
ings for his cornea lens fundus and physical
examination Excision was performed and the
mass was soft with fluid inside therefore con-
junctival pyogenic cyst was our initial diagnosis
However one month after the excision a pro-
truding mass recurred at the patientrsquos nasal can-
thus of left eye (Figure 2) There were some
differences compared to previous condition At
the first time the soft mass was contained in a
well-defined cyst wall which more favored py-
ogenic granulation However after short period
of recurrence solid consistency and unclear
margin were found which favored malignancy
Besides the mass partially involved beyond the
gray line of nasal part lower eyelid whereas last
time the cyst mainly extended from conjunctiva
of caruncle The second excisional biopsy was
performed Pathologic examination demonstrat-
ed abundant atypical lymphoid proliferation
(Figure 3A 3B) Immunohistochemical studies
showed that the lymphoid aggregation was
composed predominantly of CD20-positive cells
(Figure 3C) focal positive staining of CD3
(Figure 3D) CD5 CD23 CD10 and negative
staining of cyclin-D1 Unfortunately the cellular
morphology was difficult to be evaluated due to
marked crushing artifact Thus malignant lym-
phoma cannot be excluded totally
Orbital computed tomography (CT) showed a
lesion of soft tissue density at medial canthus of
left orbit without obvious nasolacrimal duct or
bony invasion (Figure 4A) Magnetic resonance
imaging (MRI) with contrast showed strong
enhancement at left medial canthus region (Fig-
ure 4B) There was no remarkable finding in the
systemic workup including complete blood
count and differential count biochemical pro-
files and 18F-fluoro-2-deoxyglucose positron
emission tomographycomputed tomography
(18F-FDG PETCT) indicating no evidence of
systemic involvement
After the second excision we preferred con-
servative management for him due to the uncer-
tainty of malignancy and to avoid side effects
from aggressive treatment No sign of recurrence
was noted after 10 months of observation The
follow-up photo was taken at three months after
the second operation (Figure 5)
DISCUSSION Ocular adnexal lymphoproliferative disease
(OALD) consists of the spectrum of lymphoid
disease affecting the tissues surrounding the eye
including ocular adnexal lymphomas (OAL) and
lymphoid hyperplasia (LH) [4] The conjunctiva
is an important location for extranodal lympho-
ma development which comprises 25 of OAL
[5]
OAL can be grouped into two categories based
on their appearance of cells under the micro-
scope low-grade and high-grade [6] Extranodal
marginal zone lymphoma of mucosa-associated
lymphoid tissue (EMZLMALT) is the most
common subtype of OAL followed by follicular
lymphoma [7-9] Both of the above are
low-grade lymphomas
LH can be further divided by histopathology into
reactive lymphoid hyperplasia (RLH) and atypi-
cal lymphoid hyperplasia (ALH) RLH has to-
tally benign morphology and immunophenotype
whereas ALH has borderline lesions between
RLH and lymphoma [10] OAL and LH are
mostly seen in patients with age between 50-70
years old There are rare cases in pediatric group
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
114
[71011] In the C-Y Chengrsquos statistical report of
OAL in Taiwan only 8 patients were younger
than 15 years old among the 101 cases of ocular
lymphoma [2] According to an US study inci-
dence rates of OAL were analyzed in different
age groups the group of age over 50 had the
highest incidence rate of 574 per million per-
son-years while the 0-19 age group had the
lowest incidence rate of 009 per million per-
son-years [12] The incidence of LH was even
less than OAL [13]
Patients with OALD may be asymptomatic or
with symptoms of proptosis eyelid swelling a
palpable painless mass or conjunctival salmon
patch Diplopia visual loss pain or inflamma-
tion occurred less frequently implying more
aggressive features [714]
Orbital LH is not distinguishable from low-grade
lymphoma radiologically They both typically
present a round or lobulated mass that diffusely
moderately enhances with contrast and usually
shows homogenous hypointense or isointense to
muscle barely invasion to bone or nervous sys-
tem [10] Atypical appearances including inho-
mogeneous calcification or bony changes may
be seen in high-grade lymphoma case reports
such as ocular adnexal diffuse large B-cell lym-
phoma (DLBCL) which is one of the more ag-
gressive type of OAL [7] Whole body PET is
used for not only the evaluation of systemic
involvement but also the standard for staging
lymphoma Our patientrsquos image studies revealed
neither obvious local invasion nor systemic ma-
lignancy indicating high-grade lymphoma was
less likely Low-grade lymphoma and benign
reactive lymphoid hyperplasia were still under
consideration
Histomorphology analysis and immunohisto-
chemistry (IHC) are essential for diagnosis
Flow cytometry and polymerase chain reaction
(PCR) technique are also applied to help differ-
entiate from RLH and OAL [1016] Our case
had immunohistochemical profile of positivity
for CD20 predominantly positivity focally for
CD3 CD5 CD10 CD23 and negativity for cy-
clin-D1 BCL-6 staining was not performed in
our casersquos biopsy Thus according to the IHC
report RLH ALH and follicular lymphoma are
probable diagnosis of our patient
Radiation therapy is the standard treatment for
low-grade OAL that is classified as T1N0M0 or
T2N0M0 according to the AJCC criteria [15]
İncesoy-Ouml zdemir S et al reported a 10-year-old
boy diagnosed of MALT lymphoma who was
treated with local radiotherapy (36 Gy) and
there were no local or systemic recurrences dur-
ing his nearly four-year follow-up [17] Another
case report represented a 21-year-old man of
conjunctival follicular lymphoma treated with
surgical excision only showing no evidence of
recurrence after 8 months follow-up [18] Other
treatment options for pediatric and juvenile OAL
were performed in some case reports including
intravenous rituximab intralesional interfer-
on-α-2b topical interferon a6 systemic doxycy-
cline surgical excision and postoperative local
cryotherapy [15]
Treatment for young conjunctival RLH was less
discussed in the past In a case series article
three children (9 13 14 years old respectively)
of RLH received surgical resection without fur-
ther postoperative management and no signs of
recurrence were noted during follow-up [19]
Short-term topical and oral corticosteroids after
surgical excision were prescribed in two pediat-
ric RLH patients for their small residual mass
However poor response in both cases was nota-
ble [20]
Our patient declined to receive radiotherapy or
any further postoperative treatment mainly due
to his concerning of possible side effects (such
as dry eye and cataract)
CONCLUSION We present a rare case of caruncle mass in this
report OALD is one of the relatively uncommon
diagnosis among caruncular lesions OALD
includes benign RLH and malignant OAL
which are both mainly seen in elderly patients
even rarer in pediatric or juvenile group
The standard treatment for low-grade OAL and
RLH in young patents are still debatable How-
ever long-term follow-up is suggested for both
OAL and RLH patients Though RLH has a be-
nign and self-limited course risk of malignant
transformation is possible
REFERENCES 1 Levy J Ilsar M Deckel Y et al Lesions of
the caruncle a description of 42 cases and
a review of the literature Eye
200923(5)1004-1018
2 C-Y Cheng and W-M Hsu Incidence of
eye cancer in Taiwan an 18-year review
Eye 200418152-158
3 Chui-Lien Tsen Muh-Chiou Lin
Youn-Shen Bee et al Ocular adnexal
lymphoma Five case reports and a
literature review Taiwan Journal of
Ophthalmology 20155(2)99-102
4 Liesegang TJ Ocular adnexal
lymphoproliferative lesions Mayo Clin
Proc 199368(10)1003-1010
5 Kirkegaard MM Coupland SE Prause JU
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
115
et al Malignant lymphoma of the
conjunctiva Surv Ophthalmol
201560(5)444-458
6 Stacy RC Jakobiec FA Schoenfield L et
al Unifocal and multifocal reactive
lymphoid hyperplasia vs follicular
lymphoma of the ocular adnexa Am J
Ophthalmol 2010150(3)412-426
7 Sullivan TJ Ocular Adnexal
Lymphoproliferative Disease In Guthoff
RF Katowitz JA eds Oculoplastics and
Orbit Berlin Heidelberg Springer
20101-19
8 White Valerie A Understanding and
Classification of Ocular Lymphomas
Ocular Oncology and Pathology
20195379-386
9 Stefanovic A Lossos IS Extranodal
marginal zone lymphoma of the ocular
adnexa Blood 2009114(3)501-510
10 Andrew NH Coupland SE Pirbhai A et al
Lymphoid hyperplasia of the orbit and
ocular adnexa A clinical pathologic review
Surv Ophthalmol 201661(6)778-790
11 Ferry JA1 Fung CY Zukerberg L et al
Lymphoma of the ocular adnexa A study
of 353 cases Am J Surg Pathol
200731(2)170-184
12 WM Hassan MS Bakry HM Hassan et al
Incidence of orbital conjunctival and
lacrimal gland malignant tumors in USA
from Surveillance Epidemiology and End
Results 1973-2009 Int J Ophthalmol
20169(12)1808-1813
13 Ajay A Rao John H Naheedy James Y-Y
Chen et al A Clinical Update and
Radiologic Review of Pediatric Orbital
and Ocular Tumors Journal of Oncology
2013(9)975908
14 Sullivan TJ Whitehead K Williamson R
et al Lymphoproliferative disease of the
ocular adnexa a clinical and pathologic
study with statistical analysis of 69
patients Ophthal Plast Reconstr Surg
200521177-188
15 Tanenbaum RE Galor A Dubovy SR et al
Classification diagnosis and management
of conjunctival lymphoma Eye Vis (Lond)
2019622
16 Olga Klavdianou Georgios Kondylis
Vasileios Georgopoulos et al Bilateral
benign reactive lymphoid hyperplasia of
the conjunctiva a case treated with oral
doxycycline and review of the literature
Eye Vis (Lond) 2019626
17 İncesoy-Ouml zdemir S Yuumlksek N Bozkurt C
et al A rare type of cancer in children
extranodal marginal zone B-cell (MALT)
lymphoma of the ocular adnexa Turk J
Pediatr 201456(3)295-298
18 Lynn J Poole Perry Frederick A Jakobiec
Peter A D Rubin Conjunctival Pediatric
Follicular Lymphoma Arch Ophthalmol
2012130(7)941-943
19 Abdullah Al-Mujaini Upender Wali
Anuradha Ganesh1 et al Ocular Adnexal
Reactive Lymphoid Hyperplasia in
Children Middle East Afr J Ophthalmol
201219(4)406-409
20 McLeod SD Edward DP Benign
lymphoid hyperplasia of the conjunctiva in
children Arch Ophthalmol
1999117(6)832-835
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
116
FIGURES
Figure 1 Slit lamp image of a mass lesion at the patientrsquos left eye caruncle for one month
Figure 2 One month after the first excision a protruding mass recurred at the patientrsquos nasal canthus
of left eye It partially involved beyond the gray line of nasal part lower eyelid
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
117
Figure 3 Histomorphology analysis and immunohistochemistry study of the caruncular lesion Abun-
dant atypical lymphoid proliferation presented in low-power photomicrograph (A) and
high-power photomicrograph (B) under hematoxylin-eosin staining The lymphoid aggrega-
tion was composed predominantly of CD20-positive cells (C) and focal positive staining of
CD3 (D)
Figure 4 Non-contrast orbital computed tomography showed a lesion of soft tissue density at medial
canthus of left orbit without obvious nasolacrimal duct or bony invasion (A) Magnetic reso-
nance imaging with contrast showed strong enhancement at left medial canthus region (B)
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
118
Figure 5 The follow-up photo were taken at three months after the second excision showing no signs
of recurrence
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
119
Juvenile Caruncular Atypical Lymphoid Proliferation ndash A Rare Case Report
罕見病例報告mdash青少年之淚阜非典型淋巴增生
施驊瑋 1林友祺 1
中文摘要
淚阜病灶相當罕見大部分為良性病灶眼睛及附屬結構淋巴增生疾病為其
鑑別診斷之一非常少見於年輕人或兒童我們報告一位 16歲的健康男性因
左眼淚阜無痛性腫塊接受切除手術卻於術後一個月復發執行第二次切除手術
後門診追蹤十個月未再復發此案例表現了部分良性與部分惡性腫瘤的特徵
我們針對反應性淋巴增生眼睛及附屬結構淋巴癌兩個疾病做討論及文獻回顧
關鍵字淚阜病灶眼睛及附屬結構淋巴增生疾病眼睛及附屬結構淋巴癌反
應性淋巴增生非典型淋巴增生
1 新光吳火獅紀念醫院眼科
通訊作者林友祺 電子信箱 yuchi067gmailcom
Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh 120
Submitted March 26 2020
Final version accepted April 16
2020
Case Report
Hyperacute intramembranous hemor-
rhage after burr hole craniostomy for
chronic subdural hematoma
Cite as Meng-Chi Lin Jui-Ming
Sun Yu-Hao Chen Cheng-Ta
Hsieh
Hyperacute intramembranous
hemorrhage after burr hole crani-
ostomy for chronic subdural he-
matoma Fu-Jen Journal of Medi-
cine 3(4) 120-125 2020
DOI
103966181020932020091803004
Meng-Chi Lin1 Jui-Ming Sun23 Yu-Hao Chen24 Cheng-Ta
Hsieh567
1Department of Surgery Zuoying Branch Kaohsiung Armed Forces
General Hospital Kaohsiung 813 Taiwan 2Section of Neurosurgery Department of Surgery Chia-Yi Christian
Hospital Chia-Yi City 600 Taiwan 3Department of Biotechnology Asia University Taichung City 41354
Taiwan 4Chung-Jen Junior College of Nursing Health Sciences and Manage-
ment Chia-Yi Country 62241 Taiwan 5Division of Neurosurgery Department of Surgery Sijhih Cathay Gen-
eral Hospital New Taipei City 22174 Taiwan 6Department of Medicine School of Medicine Fu Jen Catholic Univer-
sity New Taipei City 24205 Taiwan 7Department of Neurological Surgery Tri-Service General Hospital
National Defense Medical Center Taipei 114 Taiwan
Corresponding author E-mail address
nogormail2000comtw (Cheng-Ta Hsieh)
ABSTRACT
Burr hole craniostomy with closed-system drainage is an effective and common neurosurgical procedure to manage chronic subdural hematoma Postoperative hem-orrhage a well-known but infrequent complication may result in increased neurolog-ical deficits However hyperacute intramembranous hemorrhage within the inner and outer membrane of hematoma after burr hole craniostomy with irrigation and closed-system drainage has not been described previously Herein we report a case of postoperative spontaneous hyperacute intramembranous hemorrhage after burr hole craniostomy with closed-system drainage to manage a chronic subdural hematoma we subsequently discuss the possible pathophysiological mechanisms and review the relevant literature
Keywords Chronic subdural hematoma acute subdural hematoma bleeding burr hole craniostomy
drainage
Fu-J
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Vol 3 No 4 2
Acute intram
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muscle strengs was 45 on
ale Her laborh the normal rnoted Brain
n revealed Ch a marked m
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morrhage was d inner membgure 3) No aface was obseealed an organn of fibroblasne Postoperaogical deficits
EFERENCRohde VComplicatiand closedsubdural analysis of
active bleedinerved Histolonized hematots and capilla
ative recoverywas gradual a
ON oman had a hi
gular medicatig nutritional ma lucidum referred to ohe became proxamination rScale ratings wgth score in th
the Medical ratory examinranges with nn computed
CSDH in the midline shift (ived one righth irrigation a
motor oilndashlikespace was uncal and outer marea was irrigaough the subdusystem was plcreased the rel space An emracute hemorrfrom the frone (Figure 2B
membranectma was perfo
only observebrane of theactive bleedinerved Histolonized hematots and capilla
ative recoverywas gradual a
CES V Graf Gons of burr-
d-system draihematomas
f 376 patient
ng from the ogical examinoma with prolaries in the m
y of previous and favorable
history of hypeion treatmentsupplements for more tha
our emergencyogressively drrevealed thatwere E1M5V2he left side ex
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(Figure 1) St parietal burrand closed-sy
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dural catheter laced (Figureedness of the mergency brairrhage in the ntal region to
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Vol 3 No 4 2
Acute intram
Yu-Hao Chen
vealing a layer
displaying a m
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em drainage (
rhage in the ri
2020
membranous
Cheng-Ta Hs
red type of CS
midline shift
ns (A) Bone w
(white arrow)
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and (B) Soft
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rrow) in the rig
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123
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Fu-J
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g-Chi Lin Ju
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Vol 3 No 4 2
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Yu-Hao Chen
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Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh
125
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
慢性硬腦膜下出血進行鑽顱引流手術造成超急性夾膜內出
血
林孟楫 1孫瑞明 23陳昱豪 24謝政達 567
中文摘要
鑽顱併封閉系統引流手術是治療慢性硬腦膜下出血患者一種有效且常見的
神經外科手術方式術後出血可能導致神經功能缺損惡化是眾所周知但不常見
的併發症之一然而至今仍未有鑽孔併封閉系統引流造成原本慢性硬腦膜血
塊內膜和外膜間急性夾膜間出血案例在這裡我們報告一例慢性硬腦膜下出
血病患者接受鑽顱併封閉系統引流手術治療造成術後急性夾膜間出血我們在
本文中討論可能的致病機制並回顧相關文獻
關鍵字慢性硬腦膜下出血急性硬腦膜下出血出血鑽顱術引流
1國軍高雄總醫院左營分院 外科部
2崇仁醫護管理專科學校
3亞洲大學 生物科技學系
4戴德森醫療財團法人嘉義基督教醫院 外科部 神經外科
5汐止國泰綜合醫院 神經外科
6輔仁大學 醫學系
7 國防醫學院 三軍總醫院 神經外科
通訊作者謝政達 電子信箱 nogormail2000comtw
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
126
Submitted January 21 2020
Final version accepted July 08
2020
Case Report
Hamartoma of the breast A case report
Cite as Hsuan-An Chen
Cheng-Yu Lo Shih-Hung Huang
Chin-Lung Lin
Hamartoma of the breast A case
report Fu-Jen Journal of Medicine
3(5) 126-130 2020
DOI
103966181020932020091803005
Hsuan-An Chen1 Cheng-Yu Lo
3 Shih-Hung Huang
3 Chin-Lung
Lin2
1Department of Surgery Cathay General Hospital Taipei Taiwan
2Department of General Surgery Cathay General Hospital Taipei Tai-
wan
3Department of Pathology Cathay General Hospital Taipei Taiwan
Corresponding author E-mail address
lungyungmailcom (Chin-Lung Lin)
ABSTRACT
Breast hamartoma is an uncommon benign tumor rarely associated with malignancy An
excision and histological examination is necessary for the differential diagnosis We report
a case of a 49-year-old female patient presenting with a lump in the right breast Ultrasound
examination which demonstrated a 4411 cm hypoechoic lesion with lipoma Partial mas-
tectomy was arranged and the diagnosis of a hamartoma was confirmed by the histological
examination
Keywords Breast tumor Hamartoma Ultrasound
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
127
INTRODUCTION The hamartoma is a benign tumor-like lesion
that can affect various organs of the body in-
cluding lungs kidneys skin and more rarely the
breast In 1981 the hamartomas were recognized
in the WHO classification[1] They are defined
as well-demarcated mass of mammary ducts and
lobules containing varying amounts of fibrous
and adipose tissue and producing a distinctive
mammographic image
CASE REPORT A 49 year-old female had past history of left
breast mastitis with abscess status post partial
mastectomy This time she presented to our out
patient clinic for breast examination Physical
examination revealed a painless palpable mova-
ble and painless lump at upper outer quadrant of
right breast The risk of breast cancer was not
noted and the patient did not have any family
history of breast cancer The patient also denied
any trauma history before Ultrasound examina-
tion was arranged which demonstrated a 4411
cm hypoechoic lesion with lipoma at 3 oclock 2
cm from nipple of right breast and multiple hy-
poechoic nodules of various size in both breasts
and there was no suspicious axillary lymph
nodes noted (Figure1) Surgical treatment was
arranged partial mastectomy of right breast
harmartoma was successfully performed A 32 x
31 x 21 cm tumor was completely excised
Grossly examination showed a gray to yellow
and firm to fatty The diagnosis of a hamartoma
was confirmed by the histological examination
Microscopically sections of the breast lesion
show mammary hamartoma composed of ducts
lobules with interlobular fibrous tissue and adi-
pose tissue Fibrocystic change apocrine meta-
plastic ducts and scattered foci of adenosis are
noted The overall lobulocentric architecture and
the 2-cell pattern of the epithelium are preserved
columnar cell change and focal microcalcifica-
tion are present (Figure2) Based on submitted
biopsy specimen in-situ or invasive tumor cells
are not identified
DISCUSSION Hamartoma of the breast is a benign tumor like
nodule it was also known as fibroadenolipoma
lipofibroadenoma or adenolipoma based on its
predominant components It was composed of
varying amounts of glandular adipose and fi-
brous tissue[2] Hamartomas were first described
in 1971 by Arrigoni et al in a study of 10 patients
which breast tumors clinically and grossly re-
sembled fibroadenomas[3]
A higher predominance of tumors exists in fe-
males compared with males Hamartomas are
slowly-growing lesions with the diameter rang-
ing from 2 cm to 5 cm sometimes hamartomas
can reach giant diameter [4]
The clinical diagnosis of hamartoma is based on
the findings from mammography sonography
and histology examinations The hamartomas are
usually incidentally diagnosed by the women
older than 40 year-old starting mammography
screening
On physicial examination harmatomas are usu-
ally occult painless they may be as large mo-
bile soft to firm masses[5] Ultrasound showed
well capsulated mass with echogenic rim and
internal heterogeneity Mammography exam
showed well-circumscribed round to oval
masses containing fat and soft tissue densities
with a thin radiopaque pseudocapsule The
pseudocapsule results from displacement of
breast parenchyma by the tumor [56] In Pa-
thology finding microglandular adenosis is pre-
sent in fibroadipose stroma surrounded by a thin
fibrous capsule It composed of a combination of
epithelial and stromal elements usually with
normal ducts or lobules although variations of
normal tissue may also be seen Fibroadenoli-
poma myoid hamartoma and chondrolipoma are
histological variations of hamartomas depend-
ing on the proportion of normal breast tissue
elements[7]
Malignancy associated with hamartomas are
very rare[8] However it has been reported
hamartomas develop into carcinoma Malignant
transformation can occur as a result of cellular
atypia in the epithelial component of the mass[9]
Surgical removal is the curative method for
breast hamartomas[10] Diagnostic material such
as mammography ultrasonography or core nee-
dle biopsy may not give the definitive diagnosis
Therefore surgical excision and histological
examination is necessary for differential diagno-
sis[111213]
Although it is rare hamartoma can be seen along
with malignancy as it is formed from similar
components of breast tissue Therefore careful
diagnosis and appropriate management including
surgery are required
REFERENCES 1 World Health Organization (1981)
Histological typing of breast tumors In
International histological classification of
tumors 1981 2nd ed
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
128
2 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11435ndash449
2006
3 ArrigoniMG DockertyMB JuddES
The identificationand treatment of
mammary hamartoma Surg Gynecol
Obstet1971 133 577-82
4 Sanal HT Ersoz N Altinel O Unal E Can
C Giant hamartoma of the breast Breast J
2006 12 84-85
5 Feder JM de Paredes ES Hogge JP
Wilken JJ Unusual breast lesions
radiologic-pathologic correlation
Radiographics 1999 19S11ndashS26
6 Murat A Ozdemir H Yildirim H Poyraz
AK Ozercan R Hamartoma of the breast
Australas Radiol 200751 Spec NoB37ndash
9
7 Fisher CJ Hanby AM Robinson L Millis
RR Mammary hamartoma-a review of 35
cases Histopathology 1992 20 99-106
8 Choi N Ko ES Invasive ductal carcinoma
in a mammary hamartoma case report and
review of the literature Korean J Radiol
2010 Nov-Dec11(6)687-91
9 Lee EH Wylie EJ Bourke AG Bastiaan
De Boer W Invasive ductal carcinoma
arising in a breast hamartoma two case
reports and a review of the literature Clin
Radiol 2003 58 80-3
10 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11 435 ‑449
2006
11 Coyne J Hobbs FM Boggis C Harland R
Lobular carcinoma in a mammary
hamartoma J Clin Pathol 199245936ndash
937
12 G M K Tse B K B Law T K F Ma A B W
Chan Hamartoma of the breast a
clinicopathological review J Clin Pathol
200255951ndash954
13 RAAmir SSheikh BreasthamartomaA
report of 14cases of an under-recognized
and under-reported entity International
Journal of Surgery Case Reports
22(2016)1ndash4
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
129
FIGURES
Figure 1 Ultrasound shows a 4411 cm hypoechoic lesion with lipoma at 3 oclock 2 cm from nipple
of right breast
Figure 2 Photomicrograph shows mammary hamartoma composed of ducts lobules with interlobular
fibrous tissue and adipose tissue
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
130
Hamartoma of the breast A case report
乳房錯構瘤罕見個案報告
陳宣安 1羅承裕 3黃世鴻 3林錦龍 2
中文摘要
乳房錯構瘤是一種罕見之乳房良性腫瘤切除手術及病理化驗來做鑑別診斷
我們報告一位 49歲女性以可觸摸到無痛性右側乳房腫塊為臨床表徵超音波
看到一個邊緣清楚低迴音的腫塊病患接受手術切除病灶病理診斷證實為乳
房錯構瘤
關鍵字乳房腫瘤錯構瘤超音波攝影
1國泰綜合醫院外科部
2國泰綜合醫院一般外科
3國泰綜合醫院病理科
通訊作者林錦龍 電子信箱 lungyungmailcom
Fu-Jen Journal of Medicine
Mission and Goals
The Fu-Jen Journal of Medicine (FJJM) is a peer-reviewed journal which
aims to enhance research quality of staffs in the College of Medicine Fu Jen
Catholic University The journal publishes original investigations across a
wide range of medical disciplines including original research articles in basic
and clinical sciences case reports review articles brief reports and letter
to the editor FJJM is now issued by the Center of Medical Education in the
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the manuscript submitted to FJJM after August first 2015 has to be prepared
in English to meet the international standards
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Publication Date
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December 01 2003
September 30 2020
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Editor-in-chief Ming-Chieh Ma
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Editors
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Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
114
[71011] In the C-Y Chengrsquos statistical report of
OAL in Taiwan only 8 patients were younger
than 15 years old among the 101 cases of ocular
lymphoma [2] According to an US study inci-
dence rates of OAL were analyzed in different
age groups the group of age over 50 had the
highest incidence rate of 574 per million per-
son-years while the 0-19 age group had the
lowest incidence rate of 009 per million per-
son-years [12] The incidence of LH was even
less than OAL [13]
Patients with OALD may be asymptomatic or
with symptoms of proptosis eyelid swelling a
palpable painless mass or conjunctival salmon
patch Diplopia visual loss pain or inflamma-
tion occurred less frequently implying more
aggressive features [714]
Orbital LH is not distinguishable from low-grade
lymphoma radiologically They both typically
present a round or lobulated mass that diffusely
moderately enhances with contrast and usually
shows homogenous hypointense or isointense to
muscle barely invasion to bone or nervous sys-
tem [10] Atypical appearances including inho-
mogeneous calcification or bony changes may
be seen in high-grade lymphoma case reports
such as ocular adnexal diffuse large B-cell lym-
phoma (DLBCL) which is one of the more ag-
gressive type of OAL [7] Whole body PET is
used for not only the evaluation of systemic
involvement but also the standard for staging
lymphoma Our patientrsquos image studies revealed
neither obvious local invasion nor systemic ma-
lignancy indicating high-grade lymphoma was
less likely Low-grade lymphoma and benign
reactive lymphoid hyperplasia were still under
consideration
Histomorphology analysis and immunohisto-
chemistry (IHC) are essential for diagnosis
Flow cytometry and polymerase chain reaction
(PCR) technique are also applied to help differ-
entiate from RLH and OAL [1016] Our case
had immunohistochemical profile of positivity
for CD20 predominantly positivity focally for
CD3 CD5 CD10 CD23 and negativity for cy-
clin-D1 BCL-6 staining was not performed in
our casersquos biopsy Thus according to the IHC
report RLH ALH and follicular lymphoma are
probable diagnosis of our patient
Radiation therapy is the standard treatment for
low-grade OAL that is classified as T1N0M0 or
T2N0M0 according to the AJCC criteria [15]
İncesoy-Ouml zdemir S et al reported a 10-year-old
boy diagnosed of MALT lymphoma who was
treated with local radiotherapy (36 Gy) and
there were no local or systemic recurrences dur-
ing his nearly four-year follow-up [17] Another
case report represented a 21-year-old man of
conjunctival follicular lymphoma treated with
surgical excision only showing no evidence of
recurrence after 8 months follow-up [18] Other
treatment options for pediatric and juvenile OAL
were performed in some case reports including
intravenous rituximab intralesional interfer-
on-α-2b topical interferon a6 systemic doxycy-
cline surgical excision and postoperative local
cryotherapy [15]
Treatment for young conjunctival RLH was less
discussed in the past In a case series article
three children (9 13 14 years old respectively)
of RLH received surgical resection without fur-
ther postoperative management and no signs of
recurrence were noted during follow-up [19]
Short-term topical and oral corticosteroids after
surgical excision were prescribed in two pediat-
ric RLH patients for their small residual mass
However poor response in both cases was nota-
ble [20]
Our patient declined to receive radiotherapy or
any further postoperative treatment mainly due
to his concerning of possible side effects (such
as dry eye and cataract)
CONCLUSION We present a rare case of caruncle mass in this
report OALD is one of the relatively uncommon
diagnosis among caruncular lesions OALD
includes benign RLH and malignant OAL
which are both mainly seen in elderly patients
even rarer in pediatric or juvenile group
The standard treatment for low-grade OAL and
RLH in young patents are still debatable How-
ever long-term follow-up is suggested for both
OAL and RLH patients Though RLH has a be-
nign and self-limited course risk of malignant
transformation is possible
REFERENCES 1 Levy J Ilsar M Deckel Y et al Lesions of
the caruncle a description of 42 cases and
a review of the literature Eye
200923(5)1004-1018
2 C-Y Cheng and W-M Hsu Incidence of
eye cancer in Taiwan an 18-year review
Eye 200418152-158
3 Chui-Lien Tsen Muh-Chiou Lin
Youn-Shen Bee et al Ocular adnexal
lymphoma Five case reports and a
literature review Taiwan Journal of
Ophthalmology 20155(2)99-102
4 Liesegang TJ Ocular adnexal
lymphoproliferative lesions Mayo Clin
Proc 199368(10)1003-1010
5 Kirkegaard MM Coupland SE Prause JU
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
115
et al Malignant lymphoma of the
conjunctiva Surv Ophthalmol
201560(5)444-458
6 Stacy RC Jakobiec FA Schoenfield L et
al Unifocal and multifocal reactive
lymphoid hyperplasia vs follicular
lymphoma of the ocular adnexa Am J
Ophthalmol 2010150(3)412-426
7 Sullivan TJ Ocular Adnexal
Lymphoproliferative Disease In Guthoff
RF Katowitz JA eds Oculoplastics and
Orbit Berlin Heidelberg Springer
20101-19
8 White Valerie A Understanding and
Classification of Ocular Lymphomas
Ocular Oncology and Pathology
20195379-386
9 Stefanovic A Lossos IS Extranodal
marginal zone lymphoma of the ocular
adnexa Blood 2009114(3)501-510
10 Andrew NH Coupland SE Pirbhai A et al
Lymphoid hyperplasia of the orbit and
ocular adnexa A clinical pathologic review
Surv Ophthalmol 201661(6)778-790
11 Ferry JA1 Fung CY Zukerberg L et al
Lymphoma of the ocular adnexa A study
of 353 cases Am J Surg Pathol
200731(2)170-184
12 WM Hassan MS Bakry HM Hassan et al
Incidence of orbital conjunctival and
lacrimal gland malignant tumors in USA
from Surveillance Epidemiology and End
Results 1973-2009 Int J Ophthalmol
20169(12)1808-1813
13 Ajay A Rao John H Naheedy James Y-Y
Chen et al A Clinical Update and
Radiologic Review of Pediatric Orbital
and Ocular Tumors Journal of Oncology
2013(9)975908
14 Sullivan TJ Whitehead K Williamson R
et al Lymphoproliferative disease of the
ocular adnexa a clinical and pathologic
study with statistical analysis of 69
patients Ophthal Plast Reconstr Surg
200521177-188
15 Tanenbaum RE Galor A Dubovy SR et al
Classification diagnosis and management
of conjunctival lymphoma Eye Vis (Lond)
2019622
16 Olga Klavdianou Georgios Kondylis
Vasileios Georgopoulos et al Bilateral
benign reactive lymphoid hyperplasia of
the conjunctiva a case treated with oral
doxycycline and review of the literature
Eye Vis (Lond) 2019626
17 İncesoy-Ouml zdemir S Yuumlksek N Bozkurt C
et al A rare type of cancer in children
extranodal marginal zone B-cell (MALT)
lymphoma of the ocular adnexa Turk J
Pediatr 201456(3)295-298
18 Lynn J Poole Perry Frederick A Jakobiec
Peter A D Rubin Conjunctival Pediatric
Follicular Lymphoma Arch Ophthalmol
2012130(7)941-943
19 Abdullah Al-Mujaini Upender Wali
Anuradha Ganesh1 et al Ocular Adnexal
Reactive Lymphoid Hyperplasia in
Children Middle East Afr J Ophthalmol
201219(4)406-409
20 McLeod SD Edward DP Benign
lymphoid hyperplasia of the conjunctiva in
children Arch Ophthalmol
1999117(6)832-835
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
116
FIGURES
Figure 1 Slit lamp image of a mass lesion at the patientrsquos left eye caruncle for one month
Figure 2 One month after the first excision a protruding mass recurred at the patientrsquos nasal canthus
of left eye It partially involved beyond the gray line of nasal part lower eyelid
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
117
Figure 3 Histomorphology analysis and immunohistochemistry study of the caruncular lesion Abun-
dant atypical lymphoid proliferation presented in low-power photomicrograph (A) and
high-power photomicrograph (B) under hematoxylin-eosin staining The lymphoid aggrega-
tion was composed predominantly of CD20-positive cells (C) and focal positive staining of
CD3 (D)
Figure 4 Non-contrast orbital computed tomography showed a lesion of soft tissue density at medial
canthus of left orbit without obvious nasolacrimal duct or bony invasion (A) Magnetic reso-
nance imaging with contrast showed strong enhancement at left medial canthus region (B)
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
118
Figure 5 The follow-up photo were taken at three months after the second excision showing no signs
of recurrence
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
119
Juvenile Caruncular Atypical Lymphoid Proliferation ndash A Rare Case Report
罕見病例報告mdash青少年之淚阜非典型淋巴增生
施驊瑋 1林友祺 1
中文摘要
淚阜病灶相當罕見大部分為良性病灶眼睛及附屬結構淋巴增生疾病為其
鑑別診斷之一非常少見於年輕人或兒童我們報告一位 16歲的健康男性因
左眼淚阜無痛性腫塊接受切除手術卻於術後一個月復發執行第二次切除手術
後門診追蹤十個月未再復發此案例表現了部分良性與部分惡性腫瘤的特徵
我們針對反應性淋巴增生眼睛及附屬結構淋巴癌兩個疾病做討論及文獻回顧
關鍵字淚阜病灶眼睛及附屬結構淋巴增生疾病眼睛及附屬結構淋巴癌反
應性淋巴增生非典型淋巴增生
1 新光吳火獅紀念醫院眼科
通訊作者林友祺 電子信箱 yuchi067gmailcom
Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh 120
Submitted March 26 2020
Final version accepted April 16
2020
Case Report
Hyperacute intramembranous hemor-
rhage after burr hole craniostomy for
chronic subdural hematoma
Cite as Meng-Chi Lin Jui-Ming
Sun Yu-Hao Chen Cheng-Ta
Hsieh
Hyperacute intramembranous
hemorrhage after burr hole crani-
ostomy for chronic subdural he-
matoma Fu-Jen Journal of Medi-
cine 3(4) 120-125 2020
DOI
103966181020932020091803004
Meng-Chi Lin1 Jui-Ming Sun23 Yu-Hao Chen24 Cheng-Ta
Hsieh567
1Department of Surgery Zuoying Branch Kaohsiung Armed Forces
General Hospital Kaohsiung 813 Taiwan 2Section of Neurosurgery Department of Surgery Chia-Yi Christian
Hospital Chia-Yi City 600 Taiwan 3Department of Biotechnology Asia University Taichung City 41354
Taiwan 4Chung-Jen Junior College of Nursing Health Sciences and Manage-
ment Chia-Yi Country 62241 Taiwan 5Division of Neurosurgery Department of Surgery Sijhih Cathay Gen-
eral Hospital New Taipei City 22174 Taiwan 6Department of Medicine School of Medicine Fu Jen Catholic Univer-
sity New Taipei City 24205 Taiwan 7Department of Neurological Surgery Tri-Service General Hospital
National Defense Medical Center Taipei 114 Taiwan
Corresponding author E-mail address
nogormail2000comtw (Cheng-Ta Hsieh)
ABSTRACT
Burr hole craniostomy with closed-system drainage is an effective and common neurosurgical procedure to manage chronic subdural hematoma Postoperative hem-orrhage a well-known but infrequent complication may result in increased neurolog-ical deficits However hyperacute intramembranous hemorrhage within the inner and outer membrane of hematoma after burr hole craniostomy with irrigation and closed-system drainage has not been described previously Herein we report a case of postoperative spontaneous hyperacute intramembranous hemorrhage after burr hole craniostomy with closed-system drainage to manage a chronic subdural hematoma we subsequently discuss the possible pathophysiological mechanisms and review the relevant literature
Keywords Chronic subdural hematoma acute subdural hematoma bleeding burr hole craniostomy
drainage
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Vol 3 No 4 2
Acute intram
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EFERENCRohde VComplicatiand closedsubdural analysis of
active bleedinerved Histolonized hematots and capilla
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ON oman had a hi
gular medicatig nutritional ma lucidum referred to ohe became proxamination rScale ratings wgth score in th
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CSDH in the midline shift (ived one righth irrigation a
motor oilndashlikespace was uncal and outer marea was irrigaough the subdusystem was plcreased the rel space An emracute hemorrfrom the frone (Figure 2B
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Vol 3 No 4 2
Acute intram
Yu-Hao Chen
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membranous
Cheng-Ta Hs
red type of CS
midline shift
ns (A) Bone w
(white arrow)
ight frontal re
hemorrhage
ieh
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window view
and (B) Soft
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showed the b
tissue windo
rrow)
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123
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Fu-J
Meng
Figu
Jen Journal o
g-Chi Lin Ju
ure 3 Intraop
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i-Ming Sun Y
perative photo
(white arrow)
ntal region to
Vol 3 No 4 2
Acute intram
Yu-Hao Chen
o revealing ac
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the previous b
2020
membranous
Cheng-Ta Hs
cute intramem
membrane (wh
burr hole cran
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ieh
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hite asterisk) o
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(white triangl
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124
mem-
from
Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh
125
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
慢性硬腦膜下出血進行鑽顱引流手術造成超急性夾膜內出
血
林孟楫 1孫瑞明 23陳昱豪 24謝政達 567
中文摘要
鑽顱併封閉系統引流手術是治療慢性硬腦膜下出血患者一種有效且常見的
神經外科手術方式術後出血可能導致神經功能缺損惡化是眾所周知但不常見
的併發症之一然而至今仍未有鑽孔併封閉系統引流造成原本慢性硬腦膜血
塊內膜和外膜間急性夾膜間出血案例在這裡我們報告一例慢性硬腦膜下出
血病患者接受鑽顱併封閉系統引流手術治療造成術後急性夾膜間出血我們在
本文中討論可能的致病機制並回顧相關文獻
關鍵字慢性硬腦膜下出血急性硬腦膜下出血出血鑽顱術引流
1國軍高雄總醫院左營分院 外科部
2崇仁醫護管理專科學校
3亞洲大學 生物科技學系
4戴德森醫療財團法人嘉義基督教醫院 外科部 神經外科
5汐止國泰綜合醫院 神經外科
6輔仁大學 醫學系
7 國防醫學院 三軍總醫院 神經外科
通訊作者謝政達 電子信箱 nogormail2000comtw
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
126
Submitted January 21 2020
Final version accepted July 08
2020
Case Report
Hamartoma of the breast A case report
Cite as Hsuan-An Chen
Cheng-Yu Lo Shih-Hung Huang
Chin-Lung Lin
Hamartoma of the breast A case
report Fu-Jen Journal of Medicine
3(5) 126-130 2020
DOI
103966181020932020091803005
Hsuan-An Chen1 Cheng-Yu Lo
3 Shih-Hung Huang
3 Chin-Lung
Lin2
1Department of Surgery Cathay General Hospital Taipei Taiwan
2Department of General Surgery Cathay General Hospital Taipei Tai-
wan
3Department of Pathology Cathay General Hospital Taipei Taiwan
Corresponding author E-mail address
lungyungmailcom (Chin-Lung Lin)
ABSTRACT
Breast hamartoma is an uncommon benign tumor rarely associated with malignancy An
excision and histological examination is necessary for the differential diagnosis We report
a case of a 49-year-old female patient presenting with a lump in the right breast Ultrasound
examination which demonstrated a 4411 cm hypoechoic lesion with lipoma Partial mas-
tectomy was arranged and the diagnosis of a hamartoma was confirmed by the histological
examination
Keywords Breast tumor Hamartoma Ultrasound
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
127
INTRODUCTION The hamartoma is a benign tumor-like lesion
that can affect various organs of the body in-
cluding lungs kidneys skin and more rarely the
breast In 1981 the hamartomas were recognized
in the WHO classification[1] They are defined
as well-demarcated mass of mammary ducts and
lobules containing varying amounts of fibrous
and adipose tissue and producing a distinctive
mammographic image
CASE REPORT A 49 year-old female had past history of left
breast mastitis with abscess status post partial
mastectomy This time she presented to our out
patient clinic for breast examination Physical
examination revealed a painless palpable mova-
ble and painless lump at upper outer quadrant of
right breast The risk of breast cancer was not
noted and the patient did not have any family
history of breast cancer The patient also denied
any trauma history before Ultrasound examina-
tion was arranged which demonstrated a 4411
cm hypoechoic lesion with lipoma at 3 oclock 2
cm from nipple of right breast and multiple hy-
poechoic nodules of various size in both breasts
and there was no suspicious axillary lymph
nodes noted (Figure1) Surgical treatment was
arranged partial mastectomy of right breast
harmartoma was successfully performed A 32 x
31 x 21 cm tumor was completely excised
Grossly examination showed a gray to yellow
and firm to fatty The diagnosis of a hamartoma
was confirmed by the histological examination
Microscopically sections of the breast lesion
show mammary hamartoma composed of ducts
lobules with interlobular fibrous tissue and adi-
pose tissue Fibrocystic change apocrine meta-
plastic ducts and scattered foci of adenosis are
noted The overall lobulocentric architecture and
the 2-cell pattern of the epithelium are preserved
columnar cell change and focal microcalcifica-
tion are present (Figure2) Based on submitted
biopsy specimen in-situ or invasive tumor cells
are not identified
DISCUSSION Hamartoma of the breast is a benign tumor like
nodule it was also known as fibroadenolipoma
lipofibroadenoma or adenolipoma based on its
predominant components It was composed of
varying amounts of glandular adipose and fi-
brous tissue[2] Hamartomas were first described
in 1971 by Arrigoni et al in a study of 10 patients
which breast tumors clinically and grossly re-
sembled fibroadenomas[3]
A higher predominance of tumors exists in fe-
males compared with males Hamartomas are
slowly-growing lesions with the diameter rang-
ing from 2 cm to 5 cm sometimes hamartomas
can reach giant diameter [4]
The clinical diagnosis of hamartoma is based on
the findings from mammography sonography
and histology examinations The hamartomas are
usually incidentally diagnosed by the women
older than 40 year-old starting mammography
screening
On physicial examination harmatomas are usu-
ally occult painless they may be as large mo-
bile soft to firm masses[5] Ultrasound showed
well capsulated mass with echogenic rim and
internal heterogeneity Mammography exam
showed well-circumscribed round to oval
masses containing fat and soft tissue densities
with a thin radiopaque pseudocapsule The
pseudocapsule results from displacement of
breast parenchyma by the tumor [56] In Pa-
thology finding microglandular adenosis is pre-
sent in fibroadipose stroma surrounded by a thin
fibrous capsule It composed of a combination of
epithelial and stromal elements usually with
normal ducts or lobules although variations of
normal tissue may also be seen Fibroadenoli-
poma myoid hamartoma and chondrolipoma are
histological variations of hamartomas depend-
ing on the proportion of normal breast tissue
elements[7]
Malignancy associated with hamartomas are
very rare[8] However it has been reported
hamartomas develop into carcinoma Malignant
transformation can occur as a result of cellular
atypia in the epithelial component of the mass[9]
Surgical removal is the curative method for
breast hamartomas[10] Diagnostic material such
as mammography ultrasonography or core nee-
dle biopsy may not give the definitive diagnosis
Therefore surgical excision and histological
examination is necessary for differential diagno-
sis[111213]
Although it is rare hamartoma can be seen along
with malignancy as it is formed from similar
components of breast tissue Therefore careful
diagnosis and appropriate management including
surgery are required
REFERENCES 1 World Health Organization (1981)
Histological typing of breast tumors In
International histological classification of
tumors 1981 2nd ed
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
128
2 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11435ndash449
2006
3 ArrigoniMG DockertyMB JuddES
The identificationand treatment of
mammary hamartoma Surg Gynecol
Obstet1971 133 577-82
4 Sanal HT Ersoz N Altinel O Unal E Can
C Giant hamartoma of the breast Breast J
2006 12 84-85
5 Feder JM de Paredes ES Hogge JP
Wilken JJ Unusual breast lesions
radiologic-pathologic correlation
Radiographics 1999 19S11ndashS26
6 Murat A Ozdemir H Yildirim H Poyraz
AK Ozercan R Hamartoma of the breast
Australas Radiol 200751 Spec NoB37ndash
9
7 Fisher CJ Hanby AM Robinson L Millis
RR Mammary hamartoma-a review of 35
cases Histopathology 1992 20 99-106
8 Choi N Ko ES Invasive ductal carcinoma
in a mammary hamartoma case report and
review of the literature Korean J Radiol
2010 Nov-Dec11(6)687-91
9 Lee EH Wylie EJ Bourke AG Bastiaan
De Boer W Invasive ductal carcinoma
arising in a breast hamartoma two case
reports and a review of the literature Clin
Radiol 2003 58 80-3
10 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11 435 ‑449
2006
11 Coyne J Hobbs FM Boggis C Harland R
Lobular carcinoma in a mammary
hamartoma J Clin Pathol 199245936ndash
937
12 G M K Tse B K B Law T K F Ma A B W
Chan Hamartoma of the breast a
clinicopathological review J Clin Pathol
200255951ndash954
13 RAAmir SSheikh BreasthamartomaA
report of 14cases of an under-recognized
and under-reported entity International
Journal of Surgery Case Reports
22(2016)1ndash4
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
129
FIGURES
Figure 1 Ultrasound shows a 4411 cm hypoechoic lesion with lipoma at 3 oclock 2 cm from nipple
of right breast
Figure 2 Photomicrograph shows mammary hamartoma composed of ducts lobules with interlobular
fibrous tissue and adipose tissue
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
130
Hamartoma of the breast A case report
乳房錯構瘤罕見個案報告
陳宣安 1羅承裕 3黃世鴻 3林錦龍 2
中文摘要
乳房錯構瘤是一種罕見之乳房良性腫瘤切除手術及病理化驗來做鑑別診斷
我們報告一位 49歲女性以可觸摸到無痛性右側乳房腫塊為臨床表徵超音波
看到一個邊緣清楚低迴音的腫塊病患接受手術切除病灶病理診斷證實為乳
房錯構瘤
關鍵字乳房腫瘤錯構瘤超音波攝影
1國泰綜合醫院外科部
2國泰綜合醫院一般外科
3國泰綜合醫院病理科
通訊作者林錦龍 電子信箱 lungyungmailcom
Fu-Jen Journal of Medicine
Mission and Goals
The Fu-Jen Journal of Medicine (FJJM) is a peer-reviewed journal which
aims to enhance research quality of staffs in the College of Medicine Fu Jen
Catholic University The journal publishes original investigations across a
wide range of medical disciplines including original research articles in basic
and clinical sciences case reports review articles brief reports and letter
to the editor FJJM is now issued by the Center of Medical Education in the
College of Medicine Fu Jen Catholic University To promote journal quality
the manuscript submitted to FJJM after August first 2015 has to be prepared
in English to meet the international standards
Issue Date
Publication Date
Institution
December 01 2003
September 30 2020
College of Medicine Fu Jen Catholic University
Honorable publisher Han-Sun Chiang
Publisher Ping-Keung Yip
Editor-in-chief Ming-Chieh Ma
Associate Editors Yu-Wen Lin
Editors
Telephone (02) 2905-3477
Address Center for Medical Education College of Medicine Fu Jen
Catholic University
No 510 Zhongzheng Rd Xinzhuang Dist New Taipei City
24205 Taiwan
Su-Jane Wang Chi-Chung Wang Chih-Ming Ho
Yih-Jing Lee Chih-Shung Wong Tze-Wah Kao
Chi-Feng Hung Rung-Fen Feng Chee-Fah Chogn
Chia-Chen Lu Zai-Ting Yeh
Dee Pei Chih-Kuang Liu
Hen-Hui Lien Chien-Hsiou Liu
Chun-Hou Liao Yi-Ju Tsai Sheng-Wen Teng
Chia-Ting Su
- 9月封面
- 9月目錄頁
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- 版權頁(SEP)
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-
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
115
et al Malignant lymphoma of the
conjunctiva Surv Ophthalmol
201560(5)444-458
6 Stacy RC Jakobiec FA Schoenfield L et
al Unifocal and multifocal reactive
lymphoid hyperplasia vs follicular
lymphoma of the ocular adnexa Am J
Ophthalmol 2010150(3)412-426
7 Sullivan TJ Ocular Adnexal
Lymphoproliferative Disease In Guthoff
RF Katowitz JA eds Oculoplastics and
Orbit Berlin Heidelberg Springer
20101-19
8 White Valerie A Understanding and
Classification of Ocular Lymphomas
Ocular Oncology and Pathology
20195379-386
9 Stefanovic A Lossos IS Extranodal
marginal zone lymphoma of the ocular
adnexa Blood 2009114(3)501-510
10 Andrew NH Coupland SE Pirbhai A et al
Lymphoid hyperplasia of the orbit and
ocular adnexa A clinical pathologic review
Surv Ophthalmol 201661(6)778-790
11 Ferry JA1 Fung CY Zukerberg L et al
Lymphoma of the ocular adnexa A study
of 353 cases Am J Surg Pathol
200731(2)170-184
12 WM Hassan MS Bakry HM Hassan et al
Incidence of orbital conjunctival and
lacrimal gland malignant tumors in USA
from Surveillance Epidemiology and End
Results 1973-2009 Int J Ophthalmol
20169(12)1808-1813
13 Ajay A Rao John H Naheedy James Y-Y
Chen et al A Clinical Update and
Radiologic Review of Pediatric Orbital
and Ocular Tumors Journal of Oncology
2013(9)975908
14 Sullivan TJ Whitehead K Williamson R
et al Lymphoproliferative disease of the
ocular adnexa a clinical and pathologic
study with statistical analysis of 69
patients Ophthal Plast Reconstr Surg
200521177-188
15 Tanenbaum RE Galor A Dubovy SR et al
Classification diagnosis and management
of conjunctival lymphoma Eye Vis (Lond)
2019622
16 Olga Klavdianou Georgios Kondylis
Vasileios Georgopoulos et al Bilateral
benign reactive lymphoid hyperplasia of
the conjunctiva a case treated with oral
doxycycline and review of the literature
Eye Vis (Lond) 2019626
17 İncesoy-Ouml zdemir S Yuumlksek N Bozkurt C
et al A rare type of cancer in children
extranodal marginal zone B-cell (MALT)
lymphoma of the ocular adnexa Turk J
Pediatr 201456(3)295-298
18 Lynn J Poole Perry Frederick A Jakobiec
Peter A D Rubin Conjunctival Pediatric
Follicular Lymphoma Arch Ophthalmol
2012130(7)941-943
19 Abdullah Al-Mujaini Upender Wali
Anuradha Ganesh1 et al Ocular Adnexal
Reactive Lymphoid Hyperplasia in
Children Middle East Afr J Ophthalmol
201219(4)406-409
20 McLeod SD Edward DP Benign
lymphoid hyperplasia of the conjunctiva in
children Arch Ophthalmol
1999117(6)832-835
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
116
FIGURES
Figure 1 Slit lamp image of a mass lesion at the patientrsquos left eye caruncle for one month
Figure 2 One month after the first excision a protruding mass recurred at the patientrsquos nasal canthus
of left eye It partially involved beyond the gray line of nasal part lower eyelid
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
117
Figure 3 Histomorphology analysis and immunohistochemistry study of the caruncular lesion Abun-
dant atypical lymphoid proliferation presented in low-power photomicrograph (A) and
high-power photomicrograph (B) under hematoxylin-eosin staining The lymphoid aggrega-
tion was composed predominantly of CD20-positive cells (C) and focal positive staining of
CD3 (D)
Figure 4 Non-contrast orbital computed tomography showed a lesion of soft tissue density at medial
canthus of left orbit without obvious nasolacrimal duct or bony invasion (A) Magnetic reso-
nance imaging with contrast showed strong enhancement at left medial canthus region (B)
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
118
Figure 5 The follow-up photo were taken at three months after the second excision showing no signs
of recurrence
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
119
Juvenile Caruncular Atypical Lymphoid Proliferation ndash A Rare Case Report
罕見病例報告mdash青少年之淚阜非典型淋巴增生
施驊瑋 1林友祺 1
中文摘要
淚阜病灶相當罕見大部分為良性病灶眼睛及附屬結構淋巴增生疾病為其
鑑別診斷之一非常少見於年輕人或兒童我們報告一位 16歲的健康男性因
左眼淚阜無痛性腫塊接受切除手術卻於術後一個月復發執行第二次切除手術
後門診追蹤十個月未再復發此案例表現了部分良性與部分惡性腫瘤的特徵
我們針對反應性淋巴增生眼睛及附屬結構淋巴癌兩個疾病做討論及文獻回顧
關鍵字淚阜病灶眼睛及附屬結構淋巴增生疾病眼睛及附屬結構淋巴癌反
應性淋巴增生非典型淋巴增生
1 新光吳火獅紀念醫院眼科
通訊作者林友祺 電子信箱 yuchi067gmailcom
Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh 120
Submitted March 26 2020
Final version accepted April 16
2020
Case Report
Hyperacute intramembranous hemor-
rhage after burr hole craniostomy for
chronic subdural hematoma
Cite as Meng-Chi Lin Jui-Ming
Sun Yu-Hao Chen Cheng-Ta
Hsieh
Hyperacute intramembranous
hemorrhage after burr hole crani-
ostomy for chronic subdural he-
matoma Fu-Jen Journal of Medi-
cine 3(4) 120-125 2020
DOI
103966181020932020091803004
Meng-Chi Lin1 Jui-Ming Sun23 Yu-Hao Chen24 Cheng-Ta
Hsieh567
1Department of Surgery Zuoying Branch Kaohsiung Armed Forces
General Hospital Kaohsiung 813 Taiwan 2Section of Neurosurgery Department of Surgery Chia-Yi Christian
Hospital Chia-Yi City 600 Taiwan 3Department of Biotechnology Asia University Taichung City 41354
Taiwan 4Chung-Jen Junior College of Nursing Health Sciences and Manage-
ment Chia-Yi Country 62241 Taiwan 5Division of Neurosurgery Department of Surgery Sijhih Cathay Gen-
eral Hospital New Taipei City 22174 Taiwan 6Department of Medicine School of Medicine Fu Jen Catholic Univer-
sity New Taipei City 24205 Taiwan 7Department of Neurological Surgery Tri-Service General Hospital
National Defense Medical Center Taipei 114 Taiwan
Corresponding author E-mail address
nogormail2000comtw (Cheng-Ta Hsieh)
ABSTRACT
Burr hole craniostomy with closed-system drainage is an effective and common neurosurgical procedure to manage chronic subdural hematoma Postoperative hem-orrhage a well-known but infrequent complication may result in increased neurolog-ical deficits However hyperacute intramembranous hemorrhage within the inner and outer membrane of hematoma after burr hole craniostomy with irrigation and closed-system drainage has not been described previously Herein we report a case of postoperative spontaneous hyperacute intramembranous hemorrhage after burr hole craniostomy with closed-system drainage to manage a chronic subdural hematoma we subsequently discuss the possible pathophysiological mechanisms and review the relevant literature
Keywords Chronic subdural hematoma acute subdural hematoma bleeding burr hole craniostomy
drainage
Fu-J
Meng
INTChromostcal inof usubdmemthat draintechnvidehemowellacutecrani[7 8withacutehole pathorelev
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Jen Journal o
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TRODUConic subdural t common contervention [1
unabsorbed andural space mbranes [4] A
burr hole cnage systems nique for CSs a favorableorrhagic com-documented e intramembriostomy for C8] Herein w
h CSDH who e intramembr
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ASE REPO1-year-old wo
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of Medicine V
i-Ming Sun Y
CTION hematoma (C
onditions requ1-3] is a prognd liquefied hbetween the
Accumulating craniostomy is an effectivDH treatmen
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[4 6 7] Horanous bleedinCSDH has rarewe report the
developed spranous hemory Subsequenal mechanismis reviewed
ORT man had a his
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h irrigation a
motor oilndashlike pace was uncol and outer mrea was irrigatugh the subduystem was pla
creased the respace An em
acute hemorrfrom the fron
(Figure 2B)membranecto
a was perforonly observed
brane of the
Vol 3 No 4 2
Acute intram
Yu-Hao Chen
CSDH) one ofuiring neurosugressive collechematomas in
outer and ievidence suggwith or wite and widely ut and that it ] Recurrence r this surgerywever the hyng after burr ely been discucase of a pa
pontaneous hyrrhages after ntly the poss
m is discussed
story of hyperon treatment supplements for more thanur emergencygressively dro
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previous CS
2020
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Cheng-Ta Hs
f the urgi-ction n the inner gests thout used pro-and
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y de-owsy
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o the ency
moval acute outer SDH
(Figsurfrevetionbranrolo
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hemorrhage
ieh
gure 3) No aface was obseealed an organn of fibroblasne Postoperaogical deficits
ISCUSSIO61-year-old won without regd been takingning Ganodermrs She was tment when shurological exasgow Coma S
muscle strengs was 45 on
ale Her laborh the normal rnoted Brain
n revealed Ch a marked m
ently she receniostomy withinage ring surgery mthe subdural sn of the duramatoma The arile saline throsed drainage swever this inm the subduraealed a hyperdural space fniostomy siteniotomy withthe hematom
morrhage was d inner membgure 3) No aface was obseealed an organn of fibroblasne Postoperaogical deficits
EFERENCRohde VComplicatiand closedsubdural analysis of
active bleedinerved Histolonized hematots and capilla
ative recoverywas gradual a
ON oman had a hi
gular medicatig nutritional ma lucidum referred to ohe became proxamination rScale ratings wgth score in th
the Medical ratory examinranges with nn computed
CSDH in the midline shift (ived one righth irrigation a
motor oilndashlikespace was uncal and outer marea was irrigaough the subdusystem was plcreased the rel space An emracute hemorrfrom the frone (Figure 2B
membranectma was perfo
only observebrane of theactive bleedinerved Histolonized hematots and capilla
ative recoverywas gradual a
CES V Graf Gons of burr-
d-system draihematomas
f 376 patient
ng from the ogical examinoma with prolaries in the m
y of previous and favorable
history of hypeion treatmentsupplements for more tha
our emergencyogressively drrevealed thatwere E1M5V2he left side ex
Research Conation results no bleeding ditomography right hemisp
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Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh
125
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
慢性硬腦膜下出血進行鑽顱引流手術造成超急性夾膜內出
血
林孟楫 1孫瑞明 23陳昱豪 24謝政達 567
中文摘要
鑽顱併封閉系統引流手術是治療慢性硬腦膜下出血患者一種有效且常見的
神經外科手術方式術後出血可能導致神經功能缺損惡化是眾所周知但不常見
的併發症之一然而至今仍未有鑽孔併封閉系統引流造成原本慢性硬腦膜血
塊內膜和外膜間急性夾膜間出血案例在這裡我們報告一例慢性硬腦膜下出
血病患者接受鑽顱併封閉系統引流手術治療造成術後急性夾膜間出血我們在
本文中討論可能的致病機制並回顧相關文獻
關鍵字慢性硬腦膜下出血急性硬腦膜下出血出血鑽顱術引流
1國軍高雄總醫院左營分院 外科部
2崇仁醫護管理專科學校
3亞洲大學 生物科技學系
4戴德森醫療財團法人嘉義基督教醫院 外科部 神經外科
5汐止國泰綜合醫院 神經外科
6輔仁大學 醫學系
7 國防醫學院 三軍總醫院 神經外科
通訊作者謝政達 電子信箱 nogormail2000comtw
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
126
Submitted January 21 2020
Final version accepted July 08
2020
Case Report
Hamartoma of the breast A case report
Cite as Hsuan-An Chen
Cheng-Yu Lo Shih-Hung Huang
Chin-Lung Lin
Hamartoma of the breast A case
report Fu-Jen Journal of Medicine
3(5) 126-130 2020
DOI
103966181020932020091803005
Hsuan-An Chen1 Cheng-Yu Lo
3 Shih-Hung Huang
3 Chin-Lung
Lin2
1Department of Surgery Cathay General Hospital Taipei Taiwan
2Department of General Surgery Cathay General Hospital Taipei Tai-
wan
3Department of Pathology Cathay General Hospital Taipei Taiwan
Corresponding author E-mail address
lungyungmailcom (Chin-Lung Lin)
ABSTRACT
Breast hamartoma is an uncommon benign tumor rarely associated with malignancy An
excision and histological examination is necessary for the differential diagnosis We report
a case of a 49-year-old female patient presenting with a lump in the right breast Ultrasound
examination which demonstrated a 4411 cm hypoechoic lesion with lipoma Partial mas-
tectomy was arranged and the diagnosis of a hamartoma was confirmed by the histological
examination
Keywords Breast tumor Hamartoma Ultrasound
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
127
INTRODUCTION The hamartoma is a benign tumor-like lesion
that can affect various organs of the body in-
cluding lungs kidneys skin and more rarely the
breast In 1981 the hamartomas were recognized
in the WHO classification[1] They are defined
as well-demarcated mass of mammary ducts and
lobules containing varying amounts of fibrous
and adipose tissue and producing a distinctive
mammographic image
CASE REPORT A 49 year-old female had past history of left
breast mastitis with abscess status post partial
mastectomy This time she presented to our out
patient clinic for breast examination Physical
examination revealed a painless palpable mova-
ble and painless lump at upper outer quadrant of
right breast The risk of breast cancer was not
noted and the patient did not have any family
history of breast cancer The patient also denied
any trauma history before Ultrasound examina-
tion was arranged which demonstrated a 4411
cm hypoechoic lesion with lipoma at 3 oclock 2
cm from nipple of right breast and multiple hy-
poechoic nodules of various size in both breasts
and there was no suspicious axillary lymph
nodes noted (Figure1) Surgical treatment was
arranged partial mastectomy of right breast
harmartoma was successfully performed A 32 x
31 x 21 cm tumor was completely excised
Grossly examination showed a gray to yellow
and firm to fatty The diagnosis of a hamartoma
was confirmed by the histological examination
Microscopically sections of the breast lesion
show mammary hamartoma composed of ducts
lobules with interlobular fibrous tissue and adi-
pose tissue Fibrocystic change apocrine meta-
plastic ducts and scattered foci of adenosis are
noted The overall lobulocentric architecture and
the 2-cell pattern of the epithelium are preserved
columnar cell change and focal microcalcifica-
tion are present (Figure2) Based on submitted
biopsy specimen in-situ or invasive tumor cells
are not identified
DISCUSSION Hamartoma of the breast is a benign tumor like
nodule it was also known as fibroadenolipoma
lipofibroadenoma or adenolipoma based on its
predominant components It was composed of
varying amounts of glandular adipose and fi-
brous tissue[2] Hamartomas were first described
in 1971 by Arrigoni et al in a study of 10 patients
which breast tumors clinically and grossly re-
sembled fibroadenomas[3]
A higher predominance of tumors exists in fe-
males compared with males Hamartomas are
slowly-growing lesions with the diameter rang-
ing from 2 cm to 5 cm sometimes hamartomas
can reach giant diameter [4]
The clinical diagnosis of hamartoma is based on
the findings from mammography sonography
and histology examinations The hamartomas are
usually incidentally diagnosed by the women
older than 40 year-old starting mammography
screening
On physicial examination harmatomas are usu-
ally occult painless they may be as large mo-
bile soft to firm masses[5] Ultrasound showed
well capsulated mass with echogenic rim and
internal heterogeneity Mammography exam
showed well-circumscribed round to oval
masses containing fat and soft tissue densities
with a thin radiopaque pseudocapsule The
pseudocapsule results from displacement of
breast parenchyma by the tumor [56] In Pa-
thology finding microglandular adenosis is pre-
sent in fibroadipose stroma surrounded by a thin
fibrous capsule It composed of a combination of
epithelial and stromal elements usually with
normal ducts or lobules although variations of
normal tissue may also be seen Fibroadenoli-
poma myoid hamartoma and chondrolipoma are
histological variations of hamartomas depend-
ing on the proportion of normal breast tissue
elements[7]
Malignancy associated with hamartomas are
very rare[8] However it has been reported
hamartomas develop into carcinoma Malignant
transformation can occur as a result of cellular
atypia in the epithelial component of the mass[9]
Surgical removal is the curative method for
breast hamartomas[10] Diagnostic material such
as mammography ultrasonography or core nee-
dle biopsy may not give the definitive diagnosis
Therefore surgical excision and histological
examination is necessary for differential diagno-
sis[111213]
Although it is rare hamartoma can be seen along
with malignancy as it is formed from similar
components of breast tissue Therefore careful
diagnosis and appropriate management including
surgery are required
REFERENCES 1 World Health Organization (1981)
Histological typing of breast tumors In
International histological classification of
tumors 1981 2nd ed
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
128
2 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11435ndash449
2006
3 ArrigoniMG DockertyMB JuddES
The identificationand treatment of
mammary hamartoma Surg Gynecol
Obstet1971 133 577-82
4 Sanal HT Ersoz N Altinel O Unal E Can
C Giant hamartoma of the breast Breast J
2006 12 84-85
5 Feder JM de Paredes ES Hogge JP
Wilken JJ Unusual breast lesions
radiologic-pathologic correlation
Radiographics 1999 19S11ndashS26
6 Murat A Ozdemir H Yildirim H Poyraz
AK Ozercan R Hamartoma of the breast
Australas Radiol 200751 Spec NoB37ndash
9
7 Fisher CJ Hanby AM Robinson L Millis
RR Mammary hamartoma-a review of 35
cases Histopathology 1992 20 99-106
8 Choi N Ko ES Invasive ductal carcinoma
in a mammary hamartoma case report and
review of the literature Korean J Radiol
2010 Nov-Dec11(6)687-91
9 Lee EH Wylie EJ Bourke AG Bastiaan
De Boer W Invasive ductal carcinoma
arising in a breast hamartoma two case
reports and a review of the literature Clin
Radiol 2003 58 80-3
10 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11 435 ‑449
2006
11 Coyne J Hobbs FM Boggis C Harland R
Lobular carcinoma in a mammary
hamartoma J Clin Pathol 199245936ndash
937
12 G M K Tse B K B Law T K F Ma A B W
Chan Hamartoma of the breast a
clinicopathological review J Clin Pathol
200255951ndash954
13 RAAmir SSheikh BreasthamartomaA
report of 14cases of an under-recognized
and under-reported entity International
Journal of Surgery Case Reports
22(2016)1ndash4
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
129
FIGURES
Figure 1 Ultrasound shows a 4411 cm hypoechoic lesion with lipoma at 3 oclock 2 cm from nipple
of right breast
Figure 2 Photomicrograph shows mammary hamartoma composed of ducts lobules with interlobular
fibrous tissue and adipose tissue
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
130
Hamartoma of the breast A case report
乳房錯構瘤罕見個案報告
陳宣安 1羅承裕 3黃世鴻 3林錦龍 2
中文摘要
乳房錯構瘤是一種罕見之乳房良性腫瘤切除手術及病理化驗來做鑑別診斷
我們報告一位 49歲女性以可觸摸到無痛性右側乳房腫塊為臨床表徵超音波
看到一個邊緣清楚低迴音的腫塊病患接受手術切除病灶病理診斷證實為乳
房錯構瘤
關鍵字乳房腫瘤錯構瘤超音波攝影
1國泰綜合醫院外科部
2國泰綜合醫院一般外科
3國泰綜合醫院病理科
通訊作者林錦龍 電子信箱 lungyungmailcom
Fu-Jen Journal of Medicine
Mission and Goals
The Fu-Jen Journal of Medicine (FJJM) is a peer-reviewed journal which
aims to enhance research quality of staffs in the College of Medicine Fu Jen
Catholic University The journal publishes original investigations across a
wide range of medical disciplines including original research articles in basic
and clinical sciences case reports review articles brief reports and letter
to the editor FJJM is now issued by the Center of Medical Education in the
College of Medicine Fu Jen Catholic University To promote journal quality
the manuscript submitted to FJJM after August first 2015 has to be prepared
in English to meet the international standards
Issue Date
Publication Date
Institution
December 01 2003
September 30 2020
College of Medicine Fu Jen Catholic University
Honorable publisher Han-Sun Chiang
Publisher Ping-Keung Yip
Editor-in-chief Ming-Chieh Ma
Associate Editors Yu-Wen Lin
Editors
Telephone (02) 2905-3477
Address Center for Medical Education College of Medicine Fu Jen
Catholic University
No 510 Zhongzheng Rd Xinzhuang Dist New Taipei City
24205 Taiwan
Su-Jane Wang Chi-Chung Wang Chih-Ming Ho
Yih-Jing Lee Chih-Shung Wong Tze-Wah Kao
Chi-Feng Hung Rung-Fen Feng Chee-Fah Chogn
Chia-Chen Lu Zai-Ting Yeh
Dee Pei Chih-Kuang Liu
Hen-Hui Lien Chien-Hsiou Liu
Chun-Hou Liao Yi-Ju Tsai Sheng-Wen Teng
Chia-Ting Su
- 9月封面
- 9月目錄頁
- 2020九月刊排版NO1_完稿
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- 版權頁(SEP)
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-
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
116
FIGURES
Figure 1 Slit lamp image of a mass lesion at the patientrsquos left eye caruncle for one month
Figure 2 One month after the first excision a protruding mass recurred at the patientrsquos nasal canthus
of left eye It partially involved beyond the gray line of nasal part lower eyelid
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
117
Figure 3 Histomorphology analysis and immunohistochemistry study of the caruncular lesion Abun-
dant atypical lymphoid proliferation presented in low-power photomicrograph (A) and
high-power photomicrograph (B) under hematoxylin-eosin staining The lymphoid aggrega-
tion was composed predominantly of CD20-positive cells (C) and focal positive staining of
CD3 (D)
Figure 4 Non-contrast orbital computed tomography showed a lesion of soft tissue density at medial
canthus of left orbit without obvious nasolacrimal duct or bony invasion (A) Magnetic reso-
nance imaging with contrast showed strong enhancement at left medial canthus region (B)
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
118
Figure 5 The follow-up photo were taken at three months after the second excision showing no signs
of recurrence
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
119
Juvenile Caruncular Atypical Lymphoid Proliferation ndash A Rare Case Report
罕見病例報告mdash青少年之淚阜非典型淋巴增生
施驊瑋 1林友祺 1
中文摘要
淚阜病灶相當罕見大部分為良性病灶眼睛及附屬結構淋巴增生疾病為其
鑑別診斷之一非常少見於年輕人或兒童我們報告一位 16歲的健康男性因
左眼淚阜無痛性腫塊接受切除手術卻於術後一個月復發執行第二次切除手術
後門診追蹤十個月未再復發此案例表現了部分良性與部分惡性腫瘤的特徵
我們針對反應性淋巴增生眼睛及附屬結構淋巴癌兩個疾病做討論及文獻回顧
關鍵字淚阜病灶眼睛及附屬結構淋巴增生疾病眼睛及附屬結構淋巴癌反
應性淋巴增生非典型淋巴增生
1 新光吳火獅紀念醫院眼科
通訊作者林友祺 電子信箱 yuchi067gmailcom
Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh 120
Submitted March 26 2020
Final version accepted April 16
2020
Case Report
Hyperacute intramembranous hemor-
rhage after burr hole craniostomy for
chronic subdural hematoma
Cite as Meng-Chi Lin Jui-Ming
Sun Yu-Hao Chen Cheng-Ta
Hsieh
Hyperacute intramembranous
hemorrhage after burr hole crani-
ostomy for chronic subdural he-
matoma Fu-Jen Journal of Medi-
cine 3(4) 120-125 2020
DOI
103966181020932020091803004
Meng-Chi Lin1 Jui-Ming Sun23 Yu-Hao Chen24 Cheng-Ta
Hsieh567
1Department of Surgery Zuoying Branch Kaohsiung Armed Forces
General Hospital Kaohsiung 813 Taiwan 2Section of Neurosurgery Department of Surgery Chia-Yi Christian
Hospital Chia-Yi City 600 Taiwan 3Department of Biotechnology Asia University Taichung City 41354
Taiwan 4Chung-Jen Junior College of Nursing Health Sciences and Manage-
ment Chia-Yi Country 62241 Taiwan 5Division of Neurosurgery Department of Surgery Sijhih Cathay Gen-
eral Hospital New Taipei City 22174 Taiwan 6Department of Medicine School of Medicine Fu Jen Catholic Univer-
sity New Taipei City 24205 Taiwan 7Department of Neurological Surgery Tri-Service General Hospital
National Defense Medical Center Taipei 114 Taiwan
Corresponding author E-mail address
nogormail2000comtw (Cheng-Ta Hsieh)
ABSTRACT
Burr hole craniostomy with closed-system drainage is an effective and common neurosurgical procedure to manage chronic subdural hematoma Postoperative hem-orrhage a well-known but infrequent complication may result in increased neurolog-ical deficits However hyperacute intramembranous hemorrhage within the inner and outer membrane of hematoma after burr hole craniostomy with irrigation and closed-system drainage has not been described previously Herein we report a case of postoperative spontaneous hyperacute intramembranous hemorrhage after burr hole craniostomy with closed-system drainage to manage a chronic subdural hematoma we subsequently discuss the possible pathophysiological mechanisms and review the relevant literature
Keywords Chronic subdural hematoma acute subdural hematoma bleeding burr hole craniostomy
drainage
Fu-J
Meng
INTChromostcal inof usubdmemthat draintechnvidehemowellacutecrani[7 8withacutehole pathorelev
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Jen Journal o
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of Medicine V
i-Ming Sun Y
CTION hematoma (C
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h irrigation a
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creased the respace An em
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(Figure 2B)membranecto
a was perforonly observed
brane of the
Vol 3 No 4 2
Acute intram
Yu-Hao Chen
CSDH) one ofuiring neurosugressive collechematomas in
outer and ievidence suggwith or wite and widely ut and that it ] Recurrence r this surgerywever the hyng after burr ely been discucase of a pa
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Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh
125
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
慢性硬腦膜下出血進行鑽顱引流手術造成超急性夾膜內出
血
林孟楫 1孫瑞明 23陳昱豪 24謝政達 567
中文摘要
鑽顱併封閉系統引流手術是治療慢性硬腦膜下出血患者一種有效且常見的
神經外科手術方式術後出血可能導致神經功能缺損惡化是眾所周知但不常見
的併發症之一然而至今仍未有鑽孔併封閉系統引流造成原本慢性硬腦膜血
塊內膜和外膜間急性夾膜間出血案例在這裡我們報告一例慢性硬腦膜下出
血病患者接受鑽顱併封閉系統引流手術治療造成術後急性夾膜間出血我們在
本文中討論可能的致病機制並回顧相關文獻
關鍵字慢性硬腦膜下出血急性硬腦膜下出血出血鑽顱術引流
1國軍高雄總醫院左營分院 外科部
2崇仁醫護管理專科學校
3亞洲大學 生物科技學系
4戴德森醫療財團法人嘉義基督教醫院 外科部 神經外科
5汐止國泰綜合醫院 神經外科
6輔仁大學 醫學系
7 國防醫學院 三軍總醫院 神經外科
通訊作者謝政達 電子信箱 nogormail2000comtw
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
126
Submitted January 21 2020
Final version accepted July 08
2020
Case Report
Hamartoma of the breast A case report
Cite as Hsuan-An Chen
Cheng-Yu Lo Shih-Hung Huang
Chin-Lung Lin
Hamartoma of the breast A case
report Fu-Jen Journal of Medicine
3(5) 126-130 2020
DOI
103966181020932020091803005
Hsuan-An Chen1 Cheng-Yu Lo
3 Shih-Hung Huang
3 Chin-Lung
Lin2
1Department of Surgery Cathay General Hospital Taipei Taiwan
2Department of General Surgery Cathay General Hospital Taipei Tai-
wan
3Department of Pathology Cathay General Hospital Taipei Taiwan
Corresponding author E-mail address
lungyungmailcom (Chin-Lung Lin)
ABSTRACT
Breast hamartoma is an uncommon benign tumor rarely associated with malignancy An
excision and histological examination is necessary for the differential diagnosis We report
a case of a 49-year-old female patient presenting with a lump in the right breast Ultrasound
examination which demonstrated a 4411 cm hypoechoic lesion with lipoma Partial mas-
tectomy was arranged and the diagnosis of a hamartoma was confirmed by the histological
examination
Keywords Breast tumor Hamartoma Ultrasound
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
127
INTRODUCTION The hamartoma is a benign tumor-like lesion
that can affect various organs of the body in-
cluding lungs kidneys skin and more rarely the
breast In 1981 the hamartomas were recognized
in the WHO classification[1] They are defined
as well-demarcated mass of mammary ducts and
lobules containing varying amounts of fibrous
and adipose tissue and producing a distinctive
mammographic image
CASE REPORT A 49 year-old female had past history of left
breast mastitis with abscess status post partial
mastectomy This time she presented to our out
patient clinic for breast examination Physical
examination revealed a painless palpable mova-
ble and painless lump at upper outer quadrant of
right breast The risk of breast cancer was not
noted and the patient did not have any family
history of breast cancer The patient also denied
any trauma history before Ultrasound examina-
tion was arranged which demonstrated a 4411
cm hypoechoic lesion with lipoma at 3 oclock 2
cm from nipple of right breast and multiple hy-
poechoic nodules of various size in both breasts
and there was no suspicious axillary lymph
nodes noted (Figure1) Surgical treatment was
arranged partial mastectomy of right breast
harmartoma was successfully performed A 32 x
31 x 21 cm tumor was completely excised
Grossly examination showed a gray to yellow
and firm to fatty The diagnosis of a hamartoma
was confirmed by the histological examination
Microscopically sections of the breast lesion
show mammary hamartoma composed of ducts
lobules with interlobular fibrous tissue and adi-
pose tissue Fibrocystic change apocrine meta-
plastic ducts and scattered foci of adenosis are
noted The overall lobulocentric architecture and
the 2-cell pattern of the epithelium are preserved
columnar cell change and focal microcalcifica-
tion are present (Figure2) Based on submitted
biopsy specimen in-situ or invasive tumor cells
are not identified
DISCUSSION Hamartoma of the breast is a benign tumor like
nodule it was also known as fibroadenolipoma
lipofibroadenoma or adenolipoma based on its
predominant components It was composed of
varying amounts of glandular adipose and fi-
brous tissue[2] Hamartomas were first described
in 1971 by Arrigoni et al in a study of 10 patients
which breast tumors clinically and grossly re-
sembled fibroadenomas[3]
A higher predominance of tumors exists in fe-
males compared with males Hamartomas are
slowly-growing lesions with the diameter rang-
ing from 2 cm to 5 cm sometimes hamartomas
can reach giant diameter [4]
The clinical diagnosis of hamartoma is based on
the findings from mammography sonography
and histology examinations The hamartomas are
usually incidentally diagnosed by the women
older than 40 year-old starting mammography
screening
On physicial examination harmatomas are usu-
ally occult painless they may be as large mo-
bile soft to firm masses[5] Ultrasound showed
well capsulated mass with echogenic rim and
internal heterogeneity Mammography exam
showed well-circumscribed round to oval
masses containing fat and soft tissue densities
with a thin radiopaque pseudocapsule The
pseudocapsule results from displacement of
breast parenchyma by the tumor [56] In Pa-
thology finding microglandular adenosis is pre-
sent in fibroadipose stroma surrounded by a thin
fibrous capsule It composed of a combination of
epithelial and stromal elements usually with
normal ducts or lobules although variations of
normal tissue may also be seen Fibroadenoli-
poma myoid hamartoma and chondrolipoma are
histological variations of hamartomas depend-
ing on the proportion of normal breast tissue
elements[7]
Malignancy associated with hamartomas are
very rare[8] However it has been reported
hamartomas develop into carcinoma Malignant
transformation can occur as a result of cellular
atypia in the epithelial component of the mass[9]
Surgical removal is the curative method for
breast hamartomas[10] Diagnostic material such
as mammography ultrasonography or core nee-
dle biopsy may not give the definitive diagnosis
Therefore surgical excision and histological
examination is necessary for differential diagno-
sis[111213]
Although it is rare hamartoma can be seen along
with malignancy as it is formed from similar
components of breast tissue Therefore careful
diagnosis and appropriate management including
surgery are required
REFERENCES 1 World Health Organization (1981)
Histological typing of breast tumors In
International histological classification of
tumors 1981 2nd ed
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
128
2 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11435ndash449
2006
3 ArrigoniMG DockertyMB JuddES
The identificationand treatment of
mammary hamartoma Surg Gynecol
Obstet1971 133 577-82
4 Sanal HT Ersoz N Altinel O Unal E Can
C Giant hamartoma of the breast Breast J
2006 12 84-85
5 Feder JM de Paredes ES Hogge JP
Wilken JJ Unusual breast lesions
radiologic-pathologic correlation
Radiographics 1999 19S11ndashS26
6 Murat A Ozdemir H Yildirim H Poyraz
AK Ozercan R Hamartoma of the breast
Australas Radiol 200751 Spec NoB37ndash
9
7 Fisher CJ Hanby AM Robinson L Millis
RR Mammary hamartoma-a review of 35
cases Histopathology 1992 20 99-106
8 Choi N Ko ES Invasive ductal carcinoma
in a mammary hamartoma case report and
review of the literature Korean J Radiol
2010 Nov-Dec11(6)687-91
9 Lee EH Wylie EJ Bourke AG Bastiaan
De Boer W Invasive ductal carcinoma
arising in a breast hamartoma two case
reports and a review of the literature Clin
Radiol 2003 58 80-3
10 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11 435 ‑449
2006
11 Coyne J Hobbs FM Boggis C Harland R
Lobular carcinoma in a mammary
hamartoma J Clin Pathol 199245936ndash
937
12 G M K Tse B K B Law T K F Ma A B W
Chan Hamartoma of the breast a
clinicopathological review J Clin Pathol
200255951ndash954
13 RAAmir SSheikh BreasthamartomaA
report of 14cases of an under-recognized
and under-reported entity International
Journal of Surgery Case Reports
22(2016)1ndash4
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
129
FIGURES
Figure 1 Ultrasound shows a 4411 cm hypoechoic lesion with lipoma at 3 oclock 2 cm from nipple
of right breast
Figure 2 Photomicrograph shows mammary hamartoma composed of ducts lobules with interlobular
fibrous tissue and adipose tissue
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
130
Hamartoma of the breast A case report
乳房錯構瘤罕見個案報告
陳宣安 1羅承裕 3黃世鴻 3林錦龍 2
中文摘要
乳房錯構瘤是一種罕見之乳房良性腫瘤切除手術及病理化驗來做鑑別診斷
我們報告一位 49歲女性以可觸摸到無痛性右側乳房腫塊為臨床表徵超音波
看到一個邊緣清楚低迴音的腫塊病患接受手術切除病灶病理診斷證實為乳
房錯構瘤
關鍵字乳房腫瘤錯構瘤超音波攝影
1國泰綜合醫院外科部
2國泰綜合醫院一般外科
3國泰綜合醫院病理科
通訊作者林錦龍 電子信箱 lungyungmailcom
Fu-Jen Journal of Medicine
Mission and Goals
The Fu-Jen Journal of Medicine (FJJM) is a peer-reviewed journal which
aims to enhance research quality of staffs in the College of Medicine Fu Jen
Catholic University The journal publishes original investigations across a
wide range of medical disciplines including original research articles in basic
and clinical sciences case reports review articles brief reports and letter
to the editor FJJM is now issued by the Center of Medical Education in the
College of Medicine Fu Jen Catholic University To promote journal quality
the manuscript submitted to FJJM after August first 2015 has to be prepared
in English to meet the international standards
Issue Date
Publication Date
Institution
December 01 2003
September 30 2020
College of Medicine Fu Jen Catholic University
Honorable publisher Han-Sun Chiang
Publisher Ping-Keung Yip
Editor-in-chief Ming-Chieh Ma
Associate Editors Yu-Wen Lin
Editors
Telephone (02) 2905-3477
Address Center for Medical Education College of Medicine Fu Jen
Catholic University
No 510 Zhongzheng Rd Xinzhuang Dist New Taipei City
24205 Taiwan
Su-Jane Wang Chi-Chung Wang Chih-Ming Ho
Yih-Jing Lee Chih-Shung Wong Tze-Wah Kao
Chi-Feng Hung Rung-Fen Feng Chee-Fah Chogn
Chia-Chen Lu Zai-Ting Yeh
Dee Pei Chih-Kuang Liu
Hen-Hui Lien Chien-Hsiou Liu
Chun-Hou Liao Yi-Ju Tsai Sheng-Wen Teng
Chia-Ting Su
- 9月封面
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- 2020九月刊排版NO1_完稿
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-
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
117
Figure 3 Histomorphology analysis and immunohistochemistry study of the caruncular lesion Abun-
dant atypical lymphoid proliferation presented in low-power photomicrograph (A) and
high-power photomicrograph (B) under hematoxylin-eosin staining The lymphoid aggrega-
tion was composed predominantly of CD20-positive cells (C) and focal positive staining of
CD3 (D)
Figure 4 Non-contrast orbital computed tomography showed a lesion of soft tissue density at medial
canthus of left orbit without obvious nasolacrimal duct or bony invasion (A) Magnetic reso-
nance imaging with contrast showed strong enhancement at left medial canthus region (B)
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
118
Figure 5 The follow-up photo were taken at three months after the second excision showing no signs
of recurrence
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
119
Juvenile Caruncular Atypical Lymphoid Proliferation ndash A Rare Case Report
罕見病例報告mdash青少年之淚阜非典型淋巴增生
施驊瑋 1林友祺 1
中文摘要
淚阜病灶相當罕見大部分為良性病灶眼睛及附屬結構淋巴增生疾病為其
鑑別診斷之一非常少見於年輕人或兒童我們報告一位 16歲的健康男性因
左眼淚阜無痛性腫塊接受切除手術卻於術後一個月復發執行第二次切除手術
後門診追蹤十個月未再復發此案例表現了部分良性與部分惡性腫瘤的特徵
我們針對反應性淋巴增生眼睛及附屬結構淋巴癌兩個疾病做討論及文獻回顧
關鍵字淚阜病灶眼睛及附屬結構淋巴增生疾病眼睛及附屬結構淋巴癌反
應性淋巴增生非典型淋巴增生
1 新光吳火獅紀念醫院眼科
通訊作者林友祺 電子信箱 yuchi067gmailcom
Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh 120
Submitted March 26 2020
Final version accepted April 16
2020
Case Report
Hyperacute intramembranous hemor-
rhage after burr hole craniostomy for
chronic subdural hematoma
Cite as Meng-Chi Lin Jui-Ming
Sun Yu-Hao Chen Cheng-Ta
Hsieh
Hyperacute intramembranous
hemorrhage after burr hole crani-
ostomy for chronic subdural he-
matoma Fu-Jen Journal of Medi-
cine 3(4) 120-125 2020
DOI
103966181020932020091803004
Meng-Chi Lin1 Jui-Ming Sun23 Yu-Hao Chen24 Cheng-Ta
Hsieh567
1Department of Surgery Zuoying Branch Kaohsiung Armed Forces
General Hospital Kaohsiung 813 Taiwan 2Section of Neurosurgery Department of Surgery Chia-Yi Christian
Hospital Chia-Yi City 600 Taiwan 3Department of Biotechnology Asia University Taichung City 41354
Taiwan 4Chung-Jen Junior College of Nursing Health Sciences and Manage-
ment Chia-Yi Country 62241 Taiwan 5Division of Neurosurgery Department of Surgery Sijhih Cathay Gen-
eral Hospital New Taipei City 22174 Taiwan 6Department of Medicine School of Medicine Fu Jen Catholic Univer-
sity New Taipei City 24205 Taiwan 7Department of Neurological Surgery Tri-Service General Hospital
National Defense Medical Center Taipei 114 Taiwan
Corresponding author E-mail address
nogormail2000comtw (Cheng-Ta Hsieh)
ABSTRACT
Burr hole craniostomy with closed-system drainage is an effective and common neurosurgical procedure to manage chronic subdural hematoma Postoperative hem-orrhage a well-known but infrequent complication may result in increased neurolog-ical deficits However hyperacute intramembranous hemorrhage within the inner and outer membrane of hematoma after burr hole craniostomy with irrigation and closed-system drainage has not been described previously Herein we report a case of postoperative spontaneous hyperacute intramembranous hemorrhage after burr hole craniostomy with closed-system drainage to manage a chronic subdural hematoma we subsequently discuss the possible pathophysiological mechanisms and review the relevant literature
Keywords Chronic subdural hematoma acute subdural hematoma bleeding burr hole craniostomy
drainage
Fu-J
Meng
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Vol 3 No 4 2
Acute intram
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Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh
125
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
慢性硬腦膜下出血進行鑽顱引流手術造成超急性夾膜內出
血
林孟楫 1孫瑞明 23陳昱豪 24謝政達 567
中文摘要
鑽顱併封閉系統引流手術是治療慢性硬腦膜下出血患者一種有效且常見的
神經外科手術方式術後出血可能導致神經功能缺損惡化是眾所周知但不常見
的併發症之一然而至今仍未有鑽孔併封閉系統引流造成原本慢性硬腦膜血
塊內膜和外膜間急性夾膜間出血案例在這裡我們報告一例慢性硬腦膜下出
血病患者接受鑽顱併封閉系統引流手術治療造成術後急性夾膜間出血我們在
本文中討論可能的致病機制並回顧相關文獻
關鍵字慢性硬腦膜下出血急性硬腦膜下出血出血鑽顱術引流
1國軍高雄總醫院左營分院 外科部
2崇仁醫護管理專科學校
3亞洲大學 生物科技學系
4戴德森醫療財團法人嘉義基督教醫院 外科部 神經外科
5汐止國泰綜合醫院 神經外科
6輔仁大學 醫學系
7 國防醫學院 三軍總醫院 神經外科
通訊作者謝政達 電子信箱 nogormail2000comtw
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
126
Submitted January 21 2020
Final version accepted July 08
2020
Case Report
Hamartoma of the breast A case report
Cite as Hsuan-An Chen
Cheng-Yu Lo Shih-Hung Huang
Chin-Lung Lin
Hamartoma of the breast A case
report Fu-Jen Journal of Medicine
3(5) 126-130 2020
DOI
103966181020932020091803005
Hsuan-An Chen1 Cheng-Yu Lo
3 Shih-Hung Huang
3 Chin-Lung
Lin2
1Department of Surgery Cathay General Hospital Taipei Taiwan
2Department of General Surgery Cathay General Hospital Taipei Tai-
wan
3Department of Pathology Cathay General Hospital Taipei Taiwan
Corresponding author E-mail address
lungyungmailcom (Chin-Lung Lin)
ABSTRACT
Breast hamartoma is an uncommon benign tumor rarely associated with malignancy An
excision and histological examination is necessary for the differential diagnosis We report
a case of a 49-year-old female patient presenting with a lump in the right breast Ultrasound
examination which demonstrated a 4411 cm hypoechoic lesion with lipoma Partial mas-
tectomy was arranged and the diagnosis of a hamartoma was confirmed by the histological
examination
Keywords Breast tumor Hamartoma Ultrasound
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
127
INTRODUCTION The hamartoma is a benign tumor-like lesion
that can affect various organs of the body in-
cluding lungs kidneys skin and more rarely the
breast In 1981 the hamartomas were recognized
in the WHO classification[1] They are defined
as well-demarcated mass of mammary ducts and
lobules containing varying amounts of fibrous
and adipose tissue and producing a distinctive
mammographic image
CASE REPORT A 49 year-old female had past history of left
breast mastitis with abscess status post partial
mastectomy This time she presented to our out
patient clinic for breast examination Physical
examination revealed a painless palpable mova-
ble and painless lump at upper outer quadrant of
right breast The risk of breast cancer was not
noted and the patient did not have any family
history of breast cancer The patient also denied
any trauma history before Ultrasound examina-
tion was arranged which demonstrated a 4411
cm hypoechoic lesion with lipoma at 3 oclock 2
cm from nipple of right breast and multiple hy-
poechoic nodules of various size in both breasts
and there was no suspicious axillary lymph
nodes noted (Figure1) Surgical treatment was
arranged partial mastectomy of right breast
harmartoma was successfully performed A 32 x
31 x 21 cm tumor was completely excised
Grossly examination showed a gray to yellow
and firm to fatty The diagnosis of a hamartoma
was confirmed by the histological examination
Microscopically sections of the breast lesion
show mammary hamartoma composed of ducts
lobules with interlobular fibrous tissue and adi-
pose tissue Fibrocystic change apocrine meta-
plastic ducts and scattered foci of adenosis are
noted The overall lobulocentric architecture and
the 2-cell pattern of the epithelium are preserved
columnar cell change and focal microcalcifica-
tion are present (Figure2) Based on submitted
biopsy specimen in-situ or invasive tumor cells
are not identified
DISCUSSION Hamartoma of the breast is a benign tumor like
nodule it was also known as fibroadenolipoma
lipofibroadenoma or adenolipoma based on its
predominant components It was composed of
varying amounts of glandular adipose and fi-
brous tissue[2] Hamartomas were first described
in 1971 by Arrigoni et al in a study of 10 patients
which breast tumors clinically and grossly re-
sembled fibroadenomas[3]
A higher predominance of tumors exists in fe-
males compared with males Hamartomas are
slowly-growing lesions with the diameter rang-
ing from 2 cm to 5 cm sometimes hamartomas
can reach giant diameter [4]
The clinical diagnosis of hamartoma is based on
the findings from mammography sonography
and histology examinations The hamartomas are
usually incidentally diagnosed by the women
older than 40 year-old starting mammography
screening
On physicial examination harmatomas are usu-
ally occult painless they may be as large mo-
bile soft to firm masses[5] Ultrasound showed
well capsulated mass with echogenic rim and
internal heterogeneity Mammography exam
showed well-circumscribed round to oval
masses containing fat and soft tissue densities
with a thin radiopaque pseudocapsule The
pseudocapsule results from displacement of
breast parenchyma by the tumor [56] In Pa-
thology finding microglandular adenosis is pre-
sent in fibroadipose stroma surrounded by a thin
fibrous capsule It composed of a combination of
epithelial and stromal elements usually with
normal ducts or lobules although variations of
normal tissue may also be seen Fibroadenoli-
poma myoid hamartoma and chondrolipoma are
histological variations of hamartomas depend-
ing on the proportion of normal breast tissue
elements[7]
Malignancy associated with hamartomas are
very rare[8] However it has been reported
hamartomas develop into carcinoma Malignant
transformation can occur as a result of cellular
atypia in the epithelial component of the mass[9]
Surgical removal is the curative method for
breast hamartomas[10] Diagnostic material such
as mammography ultrasonography or core nee-
dle biopsy may not give the definitive diagnosis
Therefore surgical excision and histological
examination is necessary for differential diagno-
sis[111213]
Although it is rare hamartoma can be seen along
with malignancy as it is formed from similar
components of breast tissue Therefore careful
diagnosis and appropriate management including
surgery are required
REFERENCES 1 World Health Organization (1981)
Histological typing of breast tumors In
International histological classification of
tumors 1981 2nd ed
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
128
2 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11435ndash449
2006
3 ArrigoniMG DockertyMB JuddES
The identificationand treatment of
mammary hamartoma Surg Gynecol
Obstet1971 133 577-82
4 Sanal HT Ersoz N Altinel O Unal E Can
C Giant hamartoma of the breast Breast J
2006 12 84-85
5 Feder JM de Paredes ES Hogge JP
Wilken JJ Unusual breast lesions
radiologic-pathologic correlation
Radiographics 1999 19S11ndashS26
6 Murat A Ozdemir H Yildirim H Poyraz
AK Ozercan R Hamartoma of the breast
Australas Radiol 200751 Spec NoB37ndash
9
7 Fisher CJ Hanby AM Robinson L Millis
RR Mammary hamartoma-a review of 35
cases Histopathology 1992 20 99-106
8 Choi N Ko ES Invasive ductal carcinoma
in a mammary hamartoma case report and
review of the literature Korean J Radiol
2010 Nov-Dec11(6)687-91
9 Lee EH Wylie EJ Bourke AG Bastiaan
De Boer W Invasive ductal carcinoma
arising in a breast hamartoma two case
reports and a review of the literature Clin
Radiol 2003 58 80-3
10 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11 435 ‑449
2006
11 Coyne J Hobbs FM Boggis C Harland R
Lobular carcinoma in a mammary
hamartoma J Clin Pathol 199245936ndash
937
12 G M K Tse B K B Law T K F Ma A B W
Chan Hamartoma of the breast a
clinicopathological review J Clin Pathol
200255951ndash954
13 RAAmir SSheikh BreasthamartomaA
report of 14cases of an under-recognized
and under-reported entity International
Journal of Surgery Case Reports
22(2016)1ndash4
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
129
FIGURES
Figure 1 Ultrasound shows a 4411 cm hypoechoic lesion with lipoma at 3 oclock 2 cm from nipple
of right breast
Figure 2 Photomicrograph shows mammary hamartoma composed of ducts lobules with interlobular
fibrous tissue and adipose tissue
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
130
Hamartoma of the breast A case report
乳房錯構瘤罕見個案報告
陳宣安 1羅承裕 3黃世鴻 3林錦龍 2
中文摘要
乳房錯構瘤是一種罕見之乳房良性腫瘤切除手術及病理化驗來做鑑別診斷
我們報告一位 49歲女性以可觸摸到無痛性右側乳房腫塊為臨床表徵超音波
看到一個邊緣清楚低迴音的腫塊病患接受手術切除病灶病理診斷證實為乳
房錯構瘤
關鍵字乳房腫瘤錯構瘤超音波攝影
1國泰綜合醫院外科部
2國泰綜合醫院一般外科
3國泰綜合醫院病理科
通訊作者林錦龍 電子信箱 lungyungmailcom
Fu-Jen Journal of Medicine
Mission and Goals
The Fu-Jen Journal of Medicine (FJJM) is a peer-reviewed journal which
aims to enhance research quality of staffs in the College of Medicine Fu Jen
Catholic University The journal publishes original investigations across a
wide range of medical disciplines including original research articles in basic
and clinical sciences case reports review articles brief reports and letter
to the editor FJJM is now issued by the Center of Medical Education in the
College of Medicine Fu Jen Catholic University To promote journal quality
the manuscript submitted to FJJM after August first 2015 has to be prepared
in English to meet the international standards
Issue Date
Publication Date
Institution
December 01 2003
September 30 2020
College of Medicine Fu Jen Catholic University
Honorable publisher Han-Sun Chiang
Publisher Ping-Keung Yip
Editor-in-chief Ming-Chieh Ma
Associate Editors Yu-Wen Lin
Editors
Telephone (02) 2905-3477
Address Center for Medical Education College of Medicine Fu Jen
Catholic University
No 510 Zhongzheng Rd Xinzhuang Dist New Taipei City
24205 Taiwan
Su-Jane Wang Chi-Chung Wang Chih-Ming Ho
Yih-Jing Lee Chih-Shung Wong Tze-Wah Kao
Chi-Feng Hung Rung-Fen Feng Chee-Fah Chogn
Chia-Chen Lu Zai-Ting Yeh
Dee Pei Chih-Kuang Liu
Hen-Hui Lien Chien-Hsiou Liu
Chun-Hou Liao Yi-Ju Tsai Sheng-Wen Teng
Chia-Ting Su
- 9月封面
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-
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
118
Figure 5 The follow-up photo were taken at three months after the second excision showing no signs
of recurrence
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
119
Juvenile Caruncular Atypical Lymphoid Proliferation ndash A Rare Case Report
罕見病例報告mdash青少年之淚阜非典型淋巴增生
施驊瑋 1林友祺 1
中文摘要
淚阜病灶相當罕見大部分為良性病灶眼睛及附屬結構淋巴增生疾病為其
鑑別診斷之一非常少見於年輕人或兒童我們報告一位 16歲的健康男性因
左眼淚阜無痛性腫塊接受切除手術卻於術後一個月復發執行第二次切除手術
後門診追蹤十個月未再復發此案例表現了部分良性與部分惡性腫瘤的特徵
我們針對反應性淋巴增生眼睛及附屬結構淋巴癌兩個疾病做討論及文獻回顧
關鍵字淚阜病灶眼睛及附屬結構淋巴增生疾病眼睛及附屬結構淋巴癌反
應性淋巴增生非典型淋巴增生
1 新光吳火獅紀念醫院眼科
通訊作者林友祺 電子信箱 yuchi067gmailcom
Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh 120
Submitted March 26 2020
Final version accepted April 16
2020
Case Report
Hyperacute intramembranous hemor-
rhage after burr hole craniostomy for
chronic subdural hematoma
Cite as Meng-Chi Lin Jui-Ming
Sun Yu-Hao Chen Cheng-Ta
Hsieh
Hyperacute intramembranous
hemorrhage after burr hole crani-
ostomy for chronic subdural he-
matoma Fu-Jen Journal of Medi-
cine 3(4) 120-125 2020
DOI
103966181020932020091803004
Meng-Chi Lin1 Jui-Ming Sun23 Yu-Hao Chen24 Cheng-Ta
Hsieh567
1Department of Surgery Zuoying Branch Kaohsiung Armed Forces
General Hospital Kaohsiung 813 Taiwan 2Section of Neurosurgery Department of Surgery Chia-Yi Christian
Hospital Chia-Yi City 600 Taiwan 3Department of Biotechnology Asia University Taichung City 41354
Taiwan 4Chung-Jen Junior College of Nursing Health Sciences and Manage-
ment Chia-Yi Country 62241 Taiwan 5Division of Neurosurgery Department of Surgery Sijhih Cathay Gen-
eral Hospital New Taipei City 22174 Taiwan 6Department of Medicine School of Medicine Fu Jen Catholic Univer-
sity New Taipei City 24205 Taiwan 7Department of Neurological Surgery Tri-Service General Hospital
National Defense Medical Center Taipei 114 Taiwan
Corresponding author E-mail address
nogormail2000comtw (Cheng-Ta Hsieh)
ABSTRACT
Burr hole craniostomy with closed-system drainage is an effective and common neurosurgical procedure to manage chronic subdural hematoma Postoperative hem-orrhage a well-known but infrequent complication may result in increased neurolog-ical deficits However hyperacute intramembranous hemorrhage within the inner and outer membrane of hematoma after burr hole craniostomy with irrigation and closed-system drainage has not been described previously Herein we report a case of postoperative spontaneous hyperacute intramembranous hemorrhage after burr hole craniostomy with closed-system drainage to manage a chronic subdural hematoma we subsequently discuss the possible pathophysiological mechanisms and review the relevant literature
Keywords Chronic subdural hematoma acute subdural hematoma bleeding burr hole craniostomy
drainage
Fu-J
Meng
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Jen Journal o
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Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh
125
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
慢性硬腦膜下出血進行鑽顱引流手術造成超急性夾膜內出
血
林孟楫 1孫瑞明 23陳昱豪 24謝政達 567
中文摘要
鑽顱併封閉系統引流手術是治療慢性硬腦膜下出血患者一種有效且常見的
神經外科手術方式術後出血可能導致神經功能缺損惡化是眾所周知但不常見
的併發症之一然而至今仍未有鑽孔併封閉系統引流造成原本慢性硬腦膜血
塊內膜和外膜間急性夾膜間出血案例在這裡我們報告一例慢性硬腦膜下出
血病患者接受鑽顱併封閉系統引流手術治療造成術後急性夾膜間出血我們在
本文中討論可能的致病機制並回顧相關文獻
關鍵字慢性硬腦膜下出血急性硬腦膜下出血出血鑽顱術引流
1國軍高雄總醫院左營分院 外科部
2崇仁醫護管理專科學校
3亞洲大學 生物科技學系
4戴德森醫療財團法人嘉義基督教醫院 外科部 神經外科
5汐止國泰綜合醫院 神經外科
6輔仁大學 醫學系
7 國防醫學院 三軍總醫院 神經外科
通訊作者謝政達 電子信箱 nogormail2000comtw
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
126
Submitted January 21 2020
Final version accepted July 08
2020
Case Report
Hamartoma of the breast A case report
Cite as Hsuan-An Chen
Cheng-Yu Lo Shih-Hung Huang
Chin-Lung Lin
Hamartoma of the breast A case
report Fu-Jen Journal of Medicine
3(5) 126-130 2020
DOI
103966181020932020091803005
Hsuan-An Chen1 Cheng-Yu Lo
3 Shih-Hung Huang
3 Chin-Lung
Lin2
1Department of Surgery Cathay General Hospital Taipei Taiwan
2Department of General Surgery Cathay General Hospital Taipei Tai-
wan
3Department of Pathology Cathay General Hospital Taipei Taiwan
Corresponding author E-mail address
lungyungmailcom (Chin-Lung Lin)
ABSTRACT
Breast hamartoma is an uncommon benign tumor rarely associated with malignancy An
excision and histological examination is necessary for the differential diagnosis We report
a case of a 49-year-old female patient presenting with a lump in the right breast Ultrasound
examination which demonstrated a 4411 cm hypoechoic lesion with lipoma Partial mas-
tectomy was arranged and the diagnosis of a hamartoma was confirmed by the histological
examination
Keywords Breast tumor Hamartoma Ultrasound
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
127
INTRODUCTION The hamartoma is a benign tumor-like lesion
that can affect various organs of the body in-
cluding lungs kidneys skin and more rarely the
breast In 1981 the hamartomas were recognized
in the WHO classification[1] They are defined
as well-demarcated mass of mammary ducts and
lobules containing varying amounts of fibrous
and adipose tissue and producing a distinctive
mammographic image
CASE REPORT A 49 year-old female had past history of left
breast mastitis with abscess status post partial
mastectomy This time she presented to our out
patient clinic for breast examination Physical
examination revealed a painless palpable mova-
ble and painless lump at upper outer quadrant of
right breast The risk of breast cancer was not
noted and the patient did not have any family
history of breast cancer The patient also denied
any trauma history before Ultrasound examina-
tion was arranged which demonstrated a 4411
cm hypoechoic lesion with lipoma at 3 oclock 2
cm from nipple of right breast and multiple hy-
poechoic nodules of various size in both breasts
and there was no suspicious axillary lymph
nodes noted (Figure1) Surgical treatment was
arranged partial mastectomy of right breast
harmartoma was successfully performed A 32 x
31 x 21 cm tumor was completely excised
Grossly examination showed a gray to yellow
and firm to fatty The diagnosis of a hamartoma
was confirmed by the histological examination
Microscopically sections of the breast lesion
show mammary hamartoma composed of ducts
lobules with interlobular fibrous tissue and adi-
pose tissue Fibrocystic change apocrine meta-
plastic ducts and scattered foci of adenosis are
noted The overall lobulocentric architecture and
the 2-cell pattern of the epithelium are preserved
columnar cell change and focal microcalcifica-
tion are present (Figure2) Based on submitted
biopsy specimen in-situ or invasive tumor cells
are not identified
DISCUSSION Hamartoma of the breast is a benign tumor like
nodule it was also known as fibroadenolipoma
lipofibroadenoma or adenolipoma based on its
predominant components It was composed of
varying amounts of glandular adipose and fi-
brous tissue[2] Hamartomas were first described
in 1971 by Arrigoni et al in a study of 10 patients
which breast tumors clinically and grossly re-
sembled fibroadenomas[3]
A higher predominance of tumors exists in fe-
males compared with males Hamartomas are
slowly-growing lesions with the diameter rang-
ing from 2 cm to 5 cm sometimes hamartomas
can reach giant diameter [4]
The clinical diagnosis of hamartoma is based on
the findings from mammography sonography
and histology examinations The hamartomas are
usually incidentally diagnosed by the women
older than 40 year-old starting mammography
screening
On physicial examination harmatomas are usu-
ally occult painless they may be as large mo-
bile soft to firm masses[5] Ultrasound showed
well capsulated mass with echogenic rim and
internal heterogeneity Mammography exam
showed well-circumscribed round to oval
masses containing fat and soft tissue densities
with a thin radiopaque pseudocapsule The
pseudocapsule results from displacement of
breast parenchyma by the tumor [56] In Pa-
thology finding microglandular adenosis is pre-
sent in fibroadipose stroma surrounded by a thin
fibrous capsule It composed of a combination of
epithelial and stromal elements usually with
normal ducts or lobules although variations of
normal tissue may also be seen Fibroadenoli-
poma myoid hamartoma and chondrolipoma are
histological variations of hamartomas depend-
ing on the proportion of normal breast tissue
elements[7]
Malignancy associated with hamartomas are
very rare[8] However it has been reported
hamartomas develop into carcinoma Malignant
transformation can occur as a result of cellular
atypia in the epithelial component of the mass[9]
Surgical removal is the curative method for
breast hamartomas[10] Diagnostic material such
as mammography ultrasonography or core nee-
dle biopsy may not give the definitive diagnosis
Therefore surgical excision and histological
examination is necessary for differential diagno-
sis[111213]
Although it is rare hamartoma can be seen along
with malignancy as it is formed from similar
components of breast tissue Therefore careful
diagnosis and appropriate management including
surgery are required
REFERENCES 1 World Health Organization (1981)
Histological typing of breast tumors In
International histological classification of
tumors 1981 2nd ed
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
128
2 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11435ndash449
2006
3 ArrigoniMG DockertyMB JuddES
The identificationand treatment of
mammary hamartoma Surg Gynecol
Obstet1971 133 577-82
4 Sanal HT Ersoz N Altinel O Unal E Can
C Giant hamartoma of the breast Breast J
2006 12 84-85
5 Feder JM de Paredes ES Hogge JP
Wilken JJ Unusual breast lesions
radiologic-pathologic correlation
Radiographics 1999 19S11ndashS26
6 Murat A Ozdemir H Yildirim H Poyraz
AK Ozercan R Hamartoma of the breast
Australas Radiol 200751 Spec NoB37ndash
9
7 Fisher CJ Hanby AM Robinson L Millis
RR Mammary hamartoma-a review of 35
cases Histopathology 1992 20 99-106
8 Choi N Ko ES Invasive ductal carcinoma
in a mammary hamartoma case report and
review of the literature Korean J Radiol
2010 Nov-Dec11(6)687-91
9 Lee EH Wylie EJ Bourke AG Bastiaan
De Boer W Invasive ductal carcinoma
arising in a breast hamartoma two case
reports and a review of the literature Clin
Radiol 2003 58 80-3
10 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11 435 ‑449
2006
11 Coyne J Hobbs FM Boggis C Harland R
Lobular carcinoma in a mammary
hamartoma J Clin Pathol 199245936ndash
937
12 G M K Tse B K B Law T K F Ma A B W
Chan Hamartoma of the breast a
clinicopathological review J Clin Pathol
200255951ndash954
13 RAAmir SSheikh BreasthamartomaA
report of 14cases of an under-recognized
and under-reported entity International
Journal of Surgery Case Reports
22(2016)1ndash4
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
129
FIGURES
Figure 1 Ultrasound shows a 4411 cm hypoechoic lesion with lipoma at 3 oclock 2 cm from nipple
of right breast
Figure 2 Photomicrograph shows mammary hamartoma composed of ducts lobules with interlobular
fibrous tissue and adipose tissue
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
130
Hamartoma of the breast A case report
乳房錯構瘤罕見個案報告
陳宣安 1羅承裕 3黃世鴻 3林錦龍 2
中文摘要
乳房錯構瘤是一種罕見之乳房良性腫瘤切除手術及病理化驗來做鑑別診斷
我們報告一位 49歲女性以可觸摸到無痛性右側乳房腫塊為臨床表徵超音波
看到一個邊緣清楚低迴音的腫塊病患接受手術切除病灶病理診斷證實為乳
房錯構瘤
關鍵字乳房腫瘤錯構瘤超音波攝影
1國泰綜合醫院外科部
2國泰綜合醫院一般外科
3國泰綜合醫院病理科
通訊作者林錦龍 電子信箱 lungyungmailcom
Fu-Jen Journal of Medicine
Mission and Goals
The Fu-Jen Journal of Medicine (FJJM) is a peer-reviewed journal which
aims to enhance research quality of staffs in the College of Medicine Fu Jen
Catholic University The journal publishes original investigations across a
wide range of medical disciplines including original research articles in basic
and clinical sciences case reports review articles brief reports and letter
to the editor FJJM is now issued by the Center of Medical Education in the
College of Medicine Fu Jen Catholic University To promote journal quality
the manuscript submitted to FJJM after August first 2015 has to be prepared
in English to meet the international standards
Issue Date
Publication Date
Institution
December 01 2003
September 30 2020
College of Medicine Fu Jen Catholic University
Honorable publisher Han-Sun Chiang
Publisher Ping-Keung Yip
Editor-in-chief Ming-Chieh Ma
Associate Editors Yu-Wen Lin
Editors
Telephone (02) 2905-3477
Address Center for Medical Education College of Medicine Fu Jen
Catholic University
No 510 Zhongzheng Rd Xinzhuang Dist New Taipei City
24205 Taiwan
Su-Jane Wang Chi-Chung Wang Chih-Ming Ho
Yih-Jing Lee Chih-Shung Wong Tze-Wah Kao
Chi-Feng Hung Rung-Fen Feng Chee-Fah Chogn
Chia-Chen Lu Zai-Ting Yeh
Dee Pei Chih-Kuang Liu
Hen-Hui Lien Chien-Hsiou Liu
Chun-Hou Liao Yi-Ju Tsai Sheng-Wen Teng
Chia-Ting Su
- 9月封面
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- 版權頁(SEP)
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-
Fu-Jen Journal of Medicine Vol 3 No 3 2020
Juvenile caruncular lymphoid proliferation
Hua-Wei Shih Yu-Chi Lin
119
Juvenile Caruncular Atypical Lymphoid Proliferation ndash A Rare Case Report
罕見病例報告mdash青少年之淚阜非典型淋巴增生
施驊瑋 1林友祺 1
中文摘要
淚阜病灶相當罕見大部分為良性病灶眼睛及附屬結構淋巴增生疾病為其
鑑別診斷之一非常少見於年輕人或兒童我們報告一位 16歲的健康男性因
左眼淚阜無痛性腫塊接受切除手術卻於術後一個月復發執行第二次切除手術
後門診追蹤十個月未再復發此案例表現了部分良性與部分惡性腫瘤的特徵
我們針對反應性淋巴增生眼睛及附屬結構淋巴癌兩個疾病做討論及文獻回顧
關鍵字淚阜病灶眼睛及附屬結構淋巴增生疾病眼睛及附屬結構淋巴癌反
應性淋巴增生非典型淋巴增生
1 新光吳火獅紀念醫院眼科
通訊作者林友祺 電子信箱 yuchi067gmailcom
Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh 120
Submitted March 26 2020
Final version accepted April 16
2020
Case Report
Hyperacute intramembranous hemor-
rhage after burr hole craniostomy for
chronic subdural hematoma
Cite as Meng-Chi Lin Jui-Ming
Sun Yu-Hao Chen Cheng-Ta
Hsieh
Hyperacute intramembranous
hemorrhage after burr hole crani-
ostomy for chronic subdural he-
matoma Fu-Jen Journal of Medi-
cine 3(4) 120-125 2020
DOI
103966181020932020091803004
Meng-Chi Lin1 Jui-Ming Sun23 Yu-Hao Chen24 Cheng-Ta
Hsieh567
1Department of Surgery Zuoying Branch Kaohsiung Armed Forces
General Hospital Kaohsiung 813 Taiwan 2Section of Neurosurgery Department of Surgery Chia-Yi Christian
Hospital Chia-Yi City 600 Taiwan 3Department of Biotechnology Asia University Taichung City 41354
Taiwan 4Chung-Jen Junior College of Nursing Health Sciences and Manage-
ment Chia-Yi Country 62241 Taiwan 5Division of Neurosurgery Department of Surgery Sijhih Cathay Gen-
eral Hospital New Taipei City 22174 Taiwan 6Department of Medicine School of Medicine Fu Jen Catholic Univer-
sity New Taipei City 24205 Taiwan 7Department of Neurological Surgery Tri-Service General Hospital
National Defense Medical Center Taipei 114 Taiwan
Corresponding author E-mail address
nogormail2000comtw (Cheng-Ta Hsieh)
ABSTRACT
Burr hole craniostomy with closed-system drainage is an effective and common neurosurgical procedure to manage chronic subdural hematoma Postoperative hem-orrhage a well-known but infrequent complication may result in increased neurolog-ical deficits However hyperacute intramembranous hemorrhage within the inner and outer membrane of hematoma after burr hole craniostomy with irrigation and closed-system drainage has not been described previously Herein we report a case of postoperative spontaneous hyperacute intramembranous hemorrhage after burr hole craniostomy with closed-system drainage to manage a chronic subdural hematoma we subsequently discuss the possible pathophysiological mechanisms and review the relevant literature
Keywords Chronic subdural hematoma acute subdural hematoma bleeding burr hole craniostomy
drainage
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Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh
125
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
慢性硬腦膜下出血進行鑽顱引流手術造成超急性夾膜內出
血
林孟楫 1孫瑞明 23陳昱豪 24謝政達 567
中文摘要
鑽顱併封閉系統引流手術是治療慢性硬腦膜下出血患者一種有效且常見的
神經外科手術方式術後出血可能導致神經功能缺損惡化是眾所周知但不常見
的併發症之一然而至今仍未有鑽孔併封閉系統引流造成原本慢性硬腦膜血
塊內膜和外膜間急性夾膜間出血案例在這裡我們報告一例慢性硬腦膜下出
血病患者接受鑽顱併封閉系統引流手術治療造成術後急性夾膜間出血我們在
本文中討論可能的致病機制並回顧相關文獻
關鍵字慢性硬腦膜下出血急性硬腦膜下出血出血鑽顱術引流
1國軍高雄總醫院左營分院 外科部
2崇仁醫護管理專科學校
3亞洲大學 生物科技學系
4戴德森醫療財團法人嘉義基督教醫院 外科部 神經外科
5汐止國泰綜合醫院 神經外科
6輔仁大學 醫學系
7 國防醫學院 三軍總醫院 神經外科
通訊作者謝政達 電子信箱 nogormail2000comtw
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
126
Submitted January 21 2020
Final version accepted July 08
2020
Case Report
Hamartoma of the breast A case report
Cite as Hsuan-An Chen
Cheng-Yu Lo Shih-Hung Huang
Chin-Lung Lin
Hamartoma of the breast A case
report Fu-Jen Journal of Medicine
3(5) 126-130 2020
DOI
103966181020932020091803005
Hsuan-An Chen1 Cheng-Yu Lo
3 Shih-Hung Huang
3 Chin-Lung
Lin2
1Department of Surgery Cathay General Hospital Taipei Taiwan
2Department of General Surgery Cathay General Hospital Taipei Tai-
wan
3Department of Pathology Cathay General Hospital Taipei Taiwan
Corresponding author E-mail address
lungyungmailcom (Chin-Lung Lin)
ABSTRACT
Breast hamartoma is an uncommon benign tumor rarely associated with malignancy An
excision and histological examination is necessary for the differential diagnosis We report
a case of a 49-year-old female patient presenting with a lump in the right breast Ultrasound
examination which demonstrated a 4411 cm hypoechoic lesion with lipoma Partial mas-
tectomy was arranged and the diagnosis of a hamartoma was confirmed by the histological
examination
Keywords Breast tumor Hamartoma Ultrasound
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
127
INTRODUCTION The hamartoma is a benign tumor-like lesion
that can affect various organs of the body in-
cluding lungs kidneys skin and more rarely the
breast In 1981 the hamartomas were recognized
in the WHO classification[1] They are defined
as well-demarcated mass of mammary ducts and
lobules containing varying amounts of fibrous
and adipose tissue and producing a distinctive
mammographic image
CASE REPORT A 49 year-old female had past history of left
breast mastitis with abscess status post partial
mastectomy This time she presented to our out
patient clinic for breast examination Physical
examination revealed a painless palpable mova-
ble and painless lump at upper outer quadrant of
right breast The risk of breast cancer was not
noted and the patient did not have any family
history of breast cancer The patient also denied
any trauma history before Ultrasound examina-
tion was arranged which demonstrated a 4411
cm hypoechoic lesion with lipoma at 3 oclock 2
cm from nipple of right breast and multiple hy-
poechoic nodules of various size in both breasts
and there was no suspicious axillary lymph
nodes noted (Figure1) Surgical treatment was
arranged partial mastectomy of right breast
harmartoma was successfully performed A 32 x
31 x 21 cm tumor was completely excised
Grossly examination showed a gray to yellow
and firm to fatty The diagnosis of a hamartoma
was confirmed by the histological examination
Microscopically sections of the breast lesion
show mammary hamartoma composed of ducts
lobules with interlobular fibrous tissue and adi-
pose tissue Fibrocystic change apocrine meta-
plastic ducts and scattered foci of adenosis are
noted The overall lobulocentric architecture and
the 2-cell pattern of the epithelium are preserved
columnar cell change and focal microcalcifica-
tion are present (Figure2) Based on submitted
biopsy specimen in-situ or invasive tumor cells
are not identified
DISCUSSION Hamartoma of the breast is a benign tumor like
nodule it was also known as fibroadenolipoma
lipofibroadenoma or adenolipoma based on its
predominant components It was composed of
varying amounts of glandular adipose and fi-
brous tissue[2] Hamartomas were first described
in 1971 by Arrigoni et al in a study of 10 patients
which breast tumors clinically and grossly re-
sembled fibroadenomas[3]
A higher predominance of tumors exists in fe-
males compared with males Hamartomas are
slowly-growing lesions with the diameter rang-
ing from 2 cm to 5 cm sometimes hamartomas
can reach giant diameter [4]
The clinical diagnosis of hamartoma is based on
the findings from mammography sonography
and histology examinations The hamartomas are
usually incidentally diagnosed by the women
older than 40 year-old starting mammography
screening
On physicial examination harmatomas are usu-
ally occult painless they may be as large mo-
bile soft to firm masses[5] Ultrasound showed
well capsulated mass with echogenic rim and
internal heterogeneity Mammography exam
showed well-circumscribed round to oval
masses containing fat and soft tissue densities
with a thin radiopaque pseudocapsule The
pseudocapsule results from displacement of
breast parenchyma by the tumor [56] In Pa-
thology finding microglandular adenosis is pre-
sent in fibroadipose stroma surrounded by a thin
fibrous capsule It composed of a combination of
epithelial and stromal elements usually with
normal ducts or lobules although variations of
normal tissue may also be seen Fibroadenoli-
poma myoid hamartoma and chondrolipoma are
histological variations of hamartomas depend-
ing on the proportion of normal breast tissue
elements[7]
Malignancy associated with hamartomas are
very rare[8] However it has been reported
hamartomas develop into carcinoma Malignant
transformation can occur as a result of cellular
atypia in the epithelial component of the mass[9]
Surgical removal is the curative method for
breast hamartomas[10] Diagnostic material such
as mammography ultrasonography or core nee-
dle biopsy may not give the definitive diagnosis
Therefore surgical excision and histological
examination is necessary for differential diagno-
sis[111213]
Although it is rare hamartoma can be seen along
with malignancy as it is formed from similar
components of breast tissue Therefore careful
diagnosis and appropriate management including
surgery are required
REFERENCES 1 World Health Organization (1981)
Histological typing of breast tumors In
International histological classification of
tumors 1981 2nd ed
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
128
2 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11435ndash449
2006
3 ArrigoniMG DockertyMB JuddES
The identificationand treatment of
mammary hamartoma Surg Gynecol
Obstet1971 133 577-82
4 Sanal HT Ersoz N Altinel O Unal E Can
C Giant hamartoma of the breast Breast J
2006 12 84-85
5 Feder JM de Paredes ES Hogge JP
Wilken JJ Unusual breast lesions
radiologic-pathologic correlation
Radiographics 1999 19S11ndashS26
6 Murat A Ozdemir H Yildirim H Poyraz
AK Ozercan R Hamartoma of the breast
Australas Radiol 200751 Spec NoB37ndash
9
7 Fisher CJ Hanby AM Robinson L Millis
RR Mammary hamartoma-a review of 35
cases Histopathology 1992 20 99-106
8 Choi N Ko ES Invasive ductal carcinoma
in a mammary hamartoma case report and
review of the literature Korean J Radiol
2010 Nov-Dec11(6)687-91
9 Lee EH Wylie EJ Bourke AG Bastiaan
De Boer W Invasive ductal carcinoma
arising in a breast hamartoma two case
reports and a review of the literature Clin
Radiol 2003 58 80-3
10 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11 435 ‑449
2006
11 Coyne J Hobbs FM Boggis C Harland R
Lobular carcinoma in a mammary
hamartoma J Clin Pathol 199245936ndash
937
12 G M K Tse B K B Law T K F Ma A B W
Chan Hamartoma of the breast a
clinicopathological review J Clin Pathol
200255951ndash954
13 RAAmir SSheikh BreasthamartomaA
report of 14cases of an under-recognized
and under-reported entity International
Journal of Surgery Case Reports
22(2016)1ndash4
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
129
FIGURES
Figure 1 Ultrasound shows a 4411 cm hypoechoic lesion with lipoma at 3 oclock 2 cm from nipple
of right breast
Figure 2 Photomicrograph shows mammary hamartoma composed of ducts lobules with interlobular
fibrous tissue and adipose tissue
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
130
Hamartoma of the breast A case report
乳房錯構瘤罕見個案報告
陳宣安 1羅承裕 3黃世鴻 3林錦龍 2
中文摘要
乳房錯構瘤是一種罕見之乳房良性腫瘤切除手術及病理化驗來做鑑別診斷
我們報告一位 49歲女性以可觸摸到無痛性右側乳房腫塊為臨床表徵超音波
看到一個邊緣清楚低迴音的腫塊病患接受手術切除病灶病理診斷證實為乳
房錯構瘤
關鍵字乳房腫瘤錯構瘤超音波攝影
1國泰綜合醫院外科部
2國泰綜合醫院一般外科
3國泰綜合醫院病理科
通訊作者林錦龍 電子信箱 lungyungmailcom
Fu-Jen Journal of Medicine
Mission and Goals
The Fu-Jen Journal of Medicine (FJJM) is a peer-reviewed journal which
aims to enhance research quality of staffs in the College of Medicine Fu Jen
Catholic University The journal publishes original investigations across a
wide range of medical disciplines including original research articles in basic
and clinical sciences case reports review articles brief reports and letter
to the editor FJJM is now issued by the Center of Medical Education in the
College of Medicine Fu Jen Catholic University To promote journal quality
the manuscript submitted to FJJM after August first 2015 has to be prepared
in English to meet the international standards
Issue Date
Publication Date
Institution
December 01 2003
September 30 2020
College of Medicine Fu Jen Catholic University
Honorable publisher Han-Sun Chiang
Publisher Ping-Keung Yip
Editor-in-chief Ming-Chieh Ma
Associate Editors Yu-Wen Lin
Editors
Telephone (02) 2905-3477
Address Center for Medical Education College of Medicine Fu Jen
Catholic University
No 510 Zhongzheng Rd Xinzhuang Dist New Taipei City
24205 Taiwan
Su-Jane Wang Chi-Chung Wang Chih-Ming Ho
Yih-Jing Lee Chih-Shung Wong Tze-Wah Kao
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Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh 120
Submitted March 26 2020
Final version accepted April 16
2020
Case Report
Hyperacute intramembranous hemor-
rhage after burr hole craniostomy for
chronic subdural hematoma
Cite as Meng-Chi Lin Jui-Ming
Sun Yu-Hao Chen Cheng-Ta
Hsieh
Hyperacute intramembranous
hemorrhage after burr hole crani-
ostomy for chronic subdural he-
matoma Fu-Jen Journal of Medi-
cine 3(4) 120-125 2020
DOI
103966181020932020091803004
Meng-Chi Lin1 Jui-Ming Sun23 Yu-Hao Chen24 Cheng-Ta
Hsieh567
1Department of Surgery Zuoying Branch Kaohsiung Armed Forces
General Hospital Kaohsiung 813 Taiwan 2Section of Neurosurgery Department of Surgery Chia-Yi Christian
Hospital Chia-Yi City 600 Taiwan 3Department of Biotechnology Asia University Taichung City 41354
Taiwan 4Chung-Jen Junior College of Nursing Health Sciences and Manage-
ment Chia-Yi Country 62241 Taiwan 5Division of Neurosurgery Department of Surgery Sijhih Cathay Gen-
eral Hospital New Taipei City 22174 Taiwan 6Department of Medicine School of Medicine Fu Jen Catholic Univer-
sity New Taipei City 24205 Taiwan 7Department of Neurological Surgery Tri-Service General Hospital
National Defense Medical Center Taipei 114 Taiwan
Corresponding author E-mail address
nogormail2000comtw (Cheng-Ta Hsieh)
ABSTRACT
Burr hole craniostomy with closed-system drainage is an effective and common neurosurgical procedure to manage chronic subdural hematoma Postoperative hem-orrhage a well-known but infrequent complication may result in increased neurolog-ical deficits However hyperacute intramembranous hemorrhage within the inner and outer membrane of hematoma after burr hole craniostomy with irrigation and closed-system drainage has not been described previously Herein we report a case of postoperative spontaneous hyperacute intramembranous hemorrhage after burr hole craniostomy with closed-system drainage to manage a chronic subdural hematoma we subsequently discuss the possible pathophysiological mechanisms and review the relevant literature
Keywords Chronic subdural hematoma acute subdural hematoma bleeding burr hole craniostomy
drainage
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Meng
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Vol 3 No 4 2
Acute intram
Yu-Hao Chen
CSDH) one ofuiring neurosugressive collechematomas in
outer and ievidence suggwith or wite and widely ut and that it ] Recurrence r this surgerywever the hyng after burr ely been discucase of a pa
pontaneous hyrrhages after ntly the poss
m is discussed
story of hyperon treatment supplements for more thanur emergencygressively dro
evealed that were E1M5V2
e left side extrResearch Couation results wo bleeding diatomography (right hemispFigure 1) Suparietal burr nd closed-sys
fluid accumulovered after e
membranes ofted with 50 mural catheter aaced (Figure dness of the f
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previous CS
2020
membranous
Cheng-Ta Hs
f the urgi-ction n the inner gests thout used pro-and
y are yper-hole
ussed atient yper-burr sible
d and
rten-She
con-n 10
y de-owsy
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phere ubse-hole stem
lated exci-f the
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125
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
慢性硬腦膜下出血進行鑽顱引流手術造成超急性夾膜內出
血
林孟楫 1孫瑞明 23陳昱豪 24謝政達 567
中文摘要
鑽顱併封閉系統引流手術是治療慢性硬腦膜下出血患者一種有效且常見的
神經外科手術方式術後出血可能導致神經功能缺損惡化是眾所周知但不常見
的併發症之一然而至今仍未有鑽孔併封閉系統引流造成原本慢性硬腦膜血
塊內膜和外膜間急性夾膜間出血案例在這裡我們報告一例慢性硬腦膜下出
血病患者接受鑽顱併封閉系統引流手術治療造成術後急性夾膜間出血我們在
本文中討論可能的致病機制並回顧相關文獻
關鍵字慢性硬腦膜下出血急性硬腦膜下出血出血鑽顱術引流
1國軍高雄總醫院左營分院 外科部
2崇仁醫護管理專科學校
3亞洲大學 生物科技學系
4戴德森醫療財團法人嘉義基督教醫院 外科部 神經外科
5汐止國泰綜合醫院 神經外科
6輔仁大學 醫學系
7 國防醫學院 三軍總醫院 神經外科
通訊作者謝政達 電子信箱 nogormail2000comtw
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
126
Submitted January 21 2020
Final version accepted July 08
2020
Case Report
Hamartoma of the breast A case report
Cite as Hsuan-An Chen
Cheng-Yu Lo Shih-Hung Huang
Chin-Lung Lin
Hamartoma of the breast A case
report Fu-Jen Journal of Medicine
3(5) 126-130 2020
DOI
103966181020932020091803005
Hsuan-An Chen1 Cheng-Yu Lo
3 Shih-Hung Huang
3 Chin-Lung
Lin2
1Department of Surgery Cathay General Hospital Taipei Taiwan
2Department of General Surgery Cathay General Hospital Taipei Tai-
wan
3Department of Pathology Cathay General Hospital Taipei Taiwan
Corresponding author E-mail address
lungyungmailcom (Chin-Lung Lin)
ABSTRACT
Breast hamartoma is an uncommon benign tumor rarely associated with malignancy An
excision and histological examination is necessary for the differential diagnosis We report
a case of a 49-year-old female patient presenting with a lump in the right breast Ultrasound
examination which demonstrated a 4411 cm hypoechoic lesion with lipoma Partial mas-
tectomy was arranged and the diagnosis of a hamartoma was confirmed by the histological
examination
Keywords Breast tumor Hamartoma Ultrasound
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
127
INTRODUCTION The hamartoma is a benign tumor-like lesion
that can affect various organs of the body in-
cluding lungs kidneys skin and more rarely the
breast In 1981 the hamartomas were recognized
in the WHO classification[1] They are defined
as well-demarcated mass of mammary ducts and
lobules containing varying amounts of fibrous
and adipose tissue and producing a distinctive
mammographic image
CASE REPORT A 49 year-old female had past history of left
breast mastitis with abscess status post partial
mastectomy This time she presented to our out
patient clinic for breast examination Physical
examination revealed a painless palpable mova-
ble and painless lump at upper outer quadrant of
right breast The risk of breast cancer was not
noted and the patient did not have any family
history of breast cancer The patient also denied
any trauma history before Ultrasound examina-
tion was arranged which demonstrated a 4411
cm hypoechoic lesion with lipoma at 3 oclock 2
cm from nipple of right breast and multiple hy-
poechoic nodules of various size in both breasts
and there was no suspicious axillary lymph
nodes noted (Figure1) Surgical treatment was
arranged partial mastectomy of right breast
harmartoma was successfully performed A 32 x
31 x 21 cm tumor was completely excised
Grossly examination showed a gray to yellow
and firm to fatty The diagnosis of a hamartoma
was confirmed by the histological examination
Microscopically sections of the breast lesion
show mammary hamartoma composed of ducts
lobules with interlobular fibrous tissue and adi-
pose tissue Fibrocystic change apocrine meta-
plastic ducts and scattered foci of adenosis are
noted The overall lobulocentric architecture and
the 2-cell pattern of the epithelium are preserved
columnar cell change and focal microcalcifica-
tion are present (Figure2) Based on submitted
biopsy specimen in-situ or invasive tumor cells
are not identified
DISCUSSION Hamartoma of the breast is a benign tumor like
nodule it was also known as fibroadenolipoma
lipofibroadenoma or adenolipoma based on its
predominant components It was composed of
varying amounts of glandular adipose and fi-
brous tissue[2] Hamartomas were first described
in 1971 by Arrigoni et al in a study of 10 patients
which breast tumors clinically and grossly re-
sembled fibroadenomas[3]
A higher predominance of tumors exists in fe-
males compared with males Hamartomas are
slowly-growing lesions with the diameter rang-
ing from 2 cm to 5 cm sometimes hamartomas
can reach giant diameter [4]
The clinical diagnosis of hamartoma is based on
the findings from mammography sonography
and histology examinations The hamartomas are
usually incidentally diagnosed by the women
older than 40 year-old starting mammography
screening
On physicial examination harmatomas are usu-
ally occult painless they may be as large mo-
bile soft to firm masses[5] Ultrasound showed
well capsulated mass with echogenic rim and
internal heterogeneity Mammography exam
showed well-circumscribed round to oval
masses containing fat and soft tissue densities
with a thin radiopaque pseudocapsule The
pseudocapsule results from displacement of
breast parenchyma by the tumor [56] In Pa-
thology finding microglandular adenosis is pre-
sent in fibroadipose stroma surrounded by a thin
fibrous capsule It composed of a combination of
epithelial and stromal elements usually with
normal ducts or lobules although variations of
normal tissue may also be seen Fibroadenoli-
poma myoid hamartoma and chondrolipoma are
histological variations of hamartomas depend-
ing on the proportion of normal breast tissue
elements[7]
Malignancy associated with hamartomas are
very rare[8] However it has been reported
hamartomas develop into carcinoma Malignant
transformation can occur as a result of cellular
atypia in the epithelial component of the mass[9]
Surgical removal is the curative method for
breast hamartomas[10] Diagnostic material such
as mammography ultrasonography or core nee-
dle biopsy may not give the definitive diagnosis
Therefore surgical excision and histological
examination is necessary for differential diagno-
sis[111213]
Although it is rare hamartoma can be seen along
with malignancy as it is formed from similar
components of breast tissue Therefore careful
diagnosis and appropriate management including
surgery are required
REFERENCES 1 World Health Organization (1981)
Histological typing of breast tumors In
International histological classification of
tumors 1981 2nd ed
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
128
2 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11435ndash449
2006
3 ArrigoniMG DockertyMB JuddES
The identificationand treatment of
mammary hamartoma Surg Gynecol
Obstet1971 133 577-82
4 Sanal HT Ersoz N Altinel O Unal E Can
C Giant hamartoma of the breast Breast J
2006 12 84-85
5 Feder JM de Paredes ES Hogge JP
Wilken JJ Unusual breast lesions
radiologic-pathologic correlation
Radiographics 1999 19S11ndashS26
6 Murat A Ozdemir H Yildirim H Poyraz
AK Ozercan R Hamartoma of the breast
Australas Radiol 200751 Spec NoB37ndash
9
7 Fisher CJ Hanby AM Robinson L Millis
RR Mammary hamartoma-a review of 35
cases Histopathology 1992 20 99-106
8 Choi N Ko ES Invasive ductal carcinoma
in a mammary hamartoma case report and
review of the literature Korean J Radiol
2010 Nov-Dec11(6)687-91
9 Lee EH Wylie EJ Bourke AG Bastiaan
De Boer W Invasive ductal carcinoma
arising in a breast hamartoma two case
reports and a review of the literature Clin
Radiol 2003 58 80-3
10 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11 435 ‑449
2006
11 Coyne J Hobbs FM Boggis C Harland R
Lobular carcinoma in a mammary
hamartoma J Clin Pathol 199245936ndash
937
12 G M K Tse B K B Law T K F Ma A B W
Chan Hamartoma of the breast a
clinicopathological review J Clin Pathol
200255951ndash954
13 RAAmir SSheikh BreasthamartomaA
report of 14cases of an under-recognized
and under-reported entity International
Journal of Surgery Case Reports
22(2016)1ndash4
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
129
FIGURES
Figure 1 Ultrasound shows a 4411 cm hypoechoic lesion with lipoma at 3 oclock 2 cm from nipple
of right breast
Figure 2 Photomicrograph shows mammary hamartoma composed of ducts lobules with interlobular
fibrous tissue and adipose tissue
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
130
Hamartoma of the breast A case report
乳房錯構瘤罕見個案報告
陳宣安 1羅承裕 3黃世鴻 3林錦龍 2
中文摘要
乳房錯構瘤是一種罕見之乳房良性腫瘤切除手術及病理化驗來做鑑別診斷
我們報告一位 49歲女性以可觸摸到無痛性右側乳房腫塊為臨床表徵超音波
看到一個邊緣清楚低迴音的腫塊病患接受手術切除病灶病理診斷證實為乳
房錯構瘤
關鍵字乳房腫瘤錯構瘤超音波攝影
1國泰綜合醫院外科部
2國泰綜合醫院一般外科
3國泰綜合醫院病理科
通訊作者林錦龍 電子信箱 lungyungmailcom
Fu-Jen Journal of Medicine
Mission and Goals
The Fu-Jen Journal of Medicine (FJJM) is a peer-reviewed journal which
aims to enhance research quality of staffs in the College of Medicine Fu Jen
Catholic University The journal publishes original investigations across a
wide range of medical disciplines including original research articles in basic
and clinical sciences case reports review articles brief reports and letter
to the editor FJJM is now issued by the Center of Medical Education in the
College of Medicine Fu Jen Catholic University To promote journal quality
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September 30 2020
College of Medicine Fu Jen Catholic University
Honorable publisher Han-Sun Chiang
Publisher Ping-Keung Yip
Editor-in-chief Ming-Chieh Ma
Associate Editors Yu-Wen Lin
Editors
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Yu-Hao Chen
Iglesias-Pais Chronic subd
treatment es Clin Ne
3-229 Tavares CB eteristics of surgical drain
atomas in Bras13 5 CJ Hsieh bdural hemattion of subdtent contralaosciences (Riy
Jr Atallah Chronic Subdensive Systemrosurg 2016
YL et al Burr e drainage
chronic subdatic review ne (Baltim
Bifone L ec Complicatinage of Chr
2020
membranous
Cheng-Ta Hs
M dural
and eurol
et al 778
nage silia
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AN dural matic 686
hole with
dural and
more)
et al tions ronic
8
9
10
11
12
13
hemorrhage
ieh
Subdural HSoc 20155Pang CH intracranialbur hole crhematomaEdlmann Eet al Pathohaematomaand implicNeuroinflamMori K Mchronic sconsecutivesurgical orecurrence 200141 37Sahyouni RMembranecHematomaNeurosurg Brodersen blood flowsubdural h197551 23Moon KSContralateroccurring chronic sNeurosci 2
Hematomas J 57 379-385 Lee SE Kiml bleeding anraniostomy foJ Neurosurg 2
E Giorgi-Collophysiology oa inflammatcations for phmmation 2017
Maeda M Sursubdural heme cases clinicoutcome corate Neurol M
71-381 R Mahboubi ctomy in C Meta-An2017104 41P Gjerris F w in patienematomas A33-239 Lee JK
ral acute subafter remov
subdural hem00714 283-2
Korean Neur
m CH et al And recurrence or chronic sub2015123 65-l S Whitfield
of chronic subtion angiogeharmacothera714 108 rgical treatmematoma in cal characteri
omplications Med Chir (To
H Tran P Chronic Sub
Analysis W8-429 Regional cer
nts with chActa Neurol S
Kim TS eubdural hemaval of calcmatoma J 286
122
osurg
Acute after
bdural -74 d PC bdural enesis apy J
ent of 500
istics and
okyo)
et al bdural World
rebral hronic Scand
et al atoma cified
Clin
Fu-J
Meng
FIG
Figu
Figu
Jen Journal o
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GURES
ure 1 Axial vi
poropar
ure 2 Axial v
my wit
cute sub
of Medicine V
i-Ming Sun Y
iew of CT rev
rietal region d
iew of subseq
th closed-syste
bdural hemorr
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Yu-Hao Chen
vealing a layer
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brane
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of Medicine V
i-Ming Sun Y
perative photo
(white arrow)
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Vol 3 No 4 2
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Yu-Hao Chen
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2020
membranous
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cute intramem
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hite asterisk) o
niostomy site
morrhage withi
of the hemato
(white triangl
in the outer m
oma situated
le)
124
mem-
from
Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh
125
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
慢性硬腦膜下出血進行鑽顱引流手術造成超急性夾膜內出
血
林孟楫 1孫瑞明 23陳昱豪 24謝政達 567
中文摘要
鑽顱併封閉系統引流手術是治療慢性硬腦膜下出血患者一種有效且常見的
神經外科手術方式術後出血可能導致神經功能缺損惡化是眾所周知但不常見
的併發症之一然而至今仍未有鑽孔併封閉系統引流造成原本慢性硬腦膜血
塊內膜和外膜間急性夾膜間出血案例在這裡我們報告一例慢性硬腦膜下出
血病患者接受鑽顱併封閉系統引流手術治療造成術後急性夾膜間出血我們在
本文中討論可能的致病機制並回顧相關文獻
關鍵字慢性硬腦膜下出血急性硬腦膜下出血出血鑽顱術引流
1國軍高雄總醫院左營分院 外科部
2崇仁醫護管理專科學校
3亞洲大學 生物科技學系
4戴德森醫療財團法人嘉義基督教醫院 外科部 神經外科
5汐止國泰綜合醫院 神經外科
6輔仁大學 醫學系
7 國防醫學院 三軍總醫院 神經外科
通訊作者謝政達 電子信箱 nogormail2000comtw
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
126
Submitted January 21 2020
Final version accepted July 08
2020
Case Report
Hamartoma of the breast A case report
Cite as Hsuan-An Chen
Cheng-Yu Lo Shih-Hung Huang
Chin-Lung Lin
Hamartoma of the breast A case
report Fu-Jen Journal of Medicine
3(5) 126-130 2020
DOI
103966181020932020091803005
Hsuan-An Chen1 Cheng-Yu Lo
3 Shih-Hung Huang
3 Chin-Lung
Lin2
1Department of Surgery Cathay General Hospital Taipei Taiwan
2Department of General Surgery Cathay General Hospital Taipei Tai-
wan
3Department of Pathology Cathay General Hospital Taipei Taiwan
Corresponding author E-mail address
lungyungmailcom (Chin-Lung Lin)
ABSTRACT
Breast hamartoma is an uncommon benign tumor rarely associated with malignancy An
excision and histological examination is necessary for the differential diagnosis We report
a case of a 49-year-old female patient presenting with a lump in the right breast Ultrasound
examination which demonstrated a 4411 cm hypoechoic lesion with lipoma Partial mas-
tectomy was arranged and the diagnosis of a hamartoma was confirmed by the histological
examination
Keywords Breast tumor Hamartoma Ultrasound
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
127
INTRODUCTION The hamartoma is a benign tumor-like lesion
that can affect various organs of the body in-
cluding lungs kidneys skin and more rarely the
breast In 1981 the hamartomas were recognized
in the WHO classification[1] They are defined
as well-demarcated mass of mammary ducts and
lobules containing varying amounts of fibrous
and adipose tissue and producing a distinctive
mammographic image
CASE REPORT A 49 year-old female had past history of left
breast mastitis with abscess status post partial
mastectomy This time she presented to our out
patient clinic for breast examination Physical
examination revealed a painless palpable mova-
ble and painless lump at upper outer quadrant of
right breast The risk of breast cancer was not
noted and the patient did not have any family
history of breast cancer The patient also denied
any trauma history before Ultrasound examina-
tion was arranged which demonstrated a 4411
cm hypoechoic lesion with lipoma at 3 oclock 2
cm from nipple of right breast and multiple hy-
poechoic nodules of various size in both breasts
and there was no suspicious axillary lymph
nodes noted (Figure1) Surgical treatment was
arranged partial mastectomy of right breast
harmartoma was successfully performed A 32 x
31 x 21 cm tumor was completely excised
Grossly examination showed a gray to yellow
and firm to fatty The diagnosis of a hamartoma
was confirmed by the histological examination
Microscopically sections of the breast lesion
show mammary hamartoma composed of ducts
lobules with interlobular fibrous tissue and adi-
pose tissue Fibrocystic change apocrine meta-
plastic ducts and scattered foci of adenosis are
noted The overall lobulocentric architecture and
the 2-cell pattern of the epithelium are preserved
columnar cell change and focal microcalcifica-
tion are present (Figure2) Based on submitted
biopsy specimen in-situ or invasive tumor cells
are not identified
DISCUSSION Hamartoma of the breast is a benign tumor like
nodule it was also known as fibroadenolipoma
lipofibroadenoma or adenolipoma based on its
predominant components It was composed of
varying amounts of glandular adipose and fi-
brous tissue[2] Hamartomas were first described
in 1971 by Arrigoni et al in a study of 10 patients
which breast tumors clinically and grossly re-
sembled fibroadenomas[3]
A higher predominance of tumors exists in fe-
males compared with males Hamartomas are
slowly-growing lesions with the diameter rang-
ing from 2 cm to 5 cm sometimes hamartomas
can reach giant diameter [4]
The clinical diagnosis of hamartoma is based on
the findings from mammography sonography
and histology examinations The hamartomas are
usually incidentally diagnosed by the women
older than 40 year-old starting mammography
screening
On physicial examination harmatomas are usu-
ally occult painless they may be as large mo-
bile soft to firm masses[5] Ultrasound showed
well capsulated mass with echogenic rim and
internal heterogeneity Mammography exam
showed well-circumscribed round to oval
masses containing fat and soft tissue densities
with a thin radiopaque pseudocapsule The
pseudocapsule results from displacement of
breast parenchyma by the tumor [56] In Pa-
thology finding microglandular adenosis is pre-
sent in fibroadipose stroma surrounded by a thin
fibrous capsule It composed of a combination of
epithelial and stromal elements usually with
normal ducts or lobules although variations of
normal tissue may also be seen Fibroadenoli-
poma myoid hamartoma and chondrolipoma are
histological variations of hamartomas depend-
ing on the proportion of normal breast tissue
elements[7]
Malignancy associated with hamartomas are
very rare[8] However it has been reported
hamartomas develop into carcinoma Malignant
transformation can occur as a result of cellular
atypia in the epithelial component of the mass[9]
Surgical removal is the curative method for
breast hamartomas[10] Diagnostic material such
as mammography ultrasonography or core nee-
dle biopsy may not give the definitive diagnosis
Therefore surgical excision and histological
examination is necessary for differential diagno-
sis[111213]
Although it is rare hamartoma can be seen along
with malignancy as it is formed from similar
components of breast tissue Therefore careful
diagnosis and appropriate management including
surgery are required
REFERENCES 1 World Health Organization (1981)
Histological typing of breast tumors In
International histological classification of
tumors 1981 2nd ed
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
128
2 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11435ndash449
2006
3 ArrigoniMG DockertyMB JuddES
The identificationand treatment of
mammary hamartoma Surg Gynecol
Obstet1971 133 577-82
4 Sanal HT Ersoz N Altinel O Unal E Can
C Giant hamartoma of the breast Breast J
2006 12 84-85
5 Feder JM de Paredes ES Hogge JP
Wilken JJ Unusual breast lesions
radiologic-pathologic correlation
Radiographics 1999 19S11ndashS26
6 Murat A Ozdemir H Yildirim H Poyraz
AK Ozercan R Hamartoma of the breast
Australas Radiol 200751 Spec NoB37ndash
9
7 Fisher CJ Hanby AM Robinson L Millis
RR Mammary hamartoma-a review of 35
cases Histopathology 1992 20 99-106
8 Choi N Ko ES Invasive ductal carcinoma
in a mammary hamartoma case report and
review of the literature Korean J Radiol
2010 Nov-Dec11(6)687-91
9 Lee EH Wylie EJ Bourke AG Bastiaan
De Boer W Invasive ductal carcinoma
arising in a breast hamartoma two case
reports and a review of the literature Clin
Radiol 2003 58 80-3
10 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11 435 ‑449
2006
11 Coyne J Hobbs FM Boggis C Harland R
Lobular carcinoma in a mammary
hamartoma J Clin Pathol 199245936ndash
937
12 G M K Tse B K B Law T K F Ma A B W
Chan Hamartoma of the breast a
clinicopathological review J Clin Pathol
200255951ndash954
13 RAAmir SSheikh BreasthamartomaA
report of 14cases of an under-recognized
and under-reported entity International
Journal of Surgery Case Reports
22(2016)1ndash4
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
129
FIGURES
Figure 1 Ultrasound shows a 4411 cm hypoechoic lesion with lipoma at 3 oclock 2 cm from nipple
of right breast
Figure 2 Photomicrograph shows mammary hamartoma composed of ducts lobules with interlobular
fibrous tissue and adipose tissue
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
130
Hamartoma of the breast A case report
乳房錯構瘤罕見個案報告
陳宣安 1羅承裕 3黃世鴻 3林錦龍 2
中文摘要
乳房錯構瘤是一種罕見之乳房良性腫瘤切除手術及病理化驗來做鑑別診斷
我們報告一位 49歲女性以可觸摸到無痛性右側乳房腫塊為臨床表徵超音波
看到一個邊緣清楚低迴音的腫塊病患接受手術切除病灶病理診斷證實為乳
房錯構瘤
關鍵字乳房腫瘤錯構瘤超音波攝影
1國泰綜合醫院外科部
2國泰綜合醫院一般外科
3國泰綜合醫院病理科
通訊作者林錦龍 電子信箱 lungyungmailcom
Fu-Jen Journal of Medicine
Mission and Goals
The Fu-Jen Journal of Medicine (FJJM) is a peer-reviewed journal which
aims to enhance research quality of staffs in the College of Medicine Fu Jen
Catholic University The journal publishes original investigations across a
wide range of medical disciplines including original research articles in basic
and clinical sciences case reports review articles brief reports and letter
to the editor FJJM is now issued by the Center of Medical Education in the
College of Medicine Fu Jen Catholic University To promote journal quality
the manuscript submitted to FJJM after August first 2015 has to be prepared
in English to meet the international standards
Issue Date
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December 01 2003
September 30 2020
College of Medicine Fu Jen Catholic University
Honorable publisher Han-Sun Chiang
Publisher Ping-Keung Yip
Editor-in-chief Ming-Chieh Ma
Associate Editors Yu-Wen Lin
Editors
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Address Center for Medical Education College of Medicine Fu Jen
Catholic University
No 510 Zhongzheng Rd Xinzhuang Dist New Taipei City
24205 Taiwan
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Chia-Chen Lu Zai-Ting Yeh
Dee Pei Chih-Kuang Liu
Hen-Hui Lien Chien-Hsiou Liu
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- 9月封面
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- 版權頁(SEP)
- 9月封底
-
Fu-J
Meng
2
3
4
5
6
7
Jen Journal o
g-Chi Lin Ju
200225 89Gelabert-GoGarcia-Alluhaematomaoutcome inNeurosurg 2Sousa EB BEpidemiologpatients whof chronic sBrazil BMCSun HL Contralateraoccurring ahematoma subdural hy201419 22Ivamoto HSSurgical TreHematomasReview W399-418 Yuan Y Wandrainage anirrigation hematoma meta-analys201897 e1Rusconi A Infrequent Following S
of Medicine V
i-Ming Sun Y
9-94 onzalez M ut A et al C surgical n 1000 case2005107 223Brandao LF Tgical charac
ho underwent subdural hemaC Surg 20131
Chang Cal acute subafter evacuatwith coexist
ygroma Neuro29-232 S Lemos HPeatments for s A CompreheWorld Neur
ng QP Cao Ynd burr holto treat c
A systemasis Medici1827 Sangiorgi SHemorrhagic
Surgical Drai
Vol 3 No 4 2
Acute intram
Yu-Hao Chen
Iglesias-Pais Chronic subd
treatment es Clin Ne
3-229 Tavares CB eteristics of surgical drain
atomas in Bras13 5 CJ Hsieh bdural hemattion of subdtent contralaosciences (Riy
Jr Atallah Chronic Subdensive Systemrosurg 2016
YL et al Burr e drainage
chronic subdatic review ne (Baltim
Bifone L ec Complicatinage of Chr
2020
membranous
Cheng-Ta Hs
M dural
and eurol
et al 778
nage silia
CT toma dural ateral yadh)
AN dural matic 686
hole with
dural and
more)
et al tions ronic
8
9
10
11
12
13
hemorrhage
ieh
Subdural HSoc 20155Pang CH intracranialbur hole crhematomaEdlmann Eet al Pathohaematomaand implicNeuroinflamMori K Mchronic sconsecutivesurgical orecurrence 200141 37Sahyouni RMembranecHematomaNeurosurg Brodersen blood flowsubdural h197551 23Moon KSContralateroccurring chronic sNeurosci 2
Hematomas J 57 379-385 Lee SE Kiml bleeding anraniostomy foJ Neurosurg 2
E Giorgi-Collophysiology oa inflammatcations for phmmation 2017
Maeda M Sursubdural heme cases clinicoutcome corate Neurol M
71-381 R Mahboubi ctomy in C Meta-An2017104 41P Gjerris F w in patienematomas A33-239 Lee JK
ral acute subafter remov
subdural hem00714 283-2
Korean Neur
m CH et al And recurrence or chronic sub2015123 65-l S Whitfield
of chronic subtion angiogeharmacothera714 108 rgical treatmematoma in cal characteri
omplications Med Chir (To
H Tran P Chronic Sub
Analysis W8-429 Regional cer
nts with chActa Neurol S
Kim TS eubdural hemaval of calcmatoma J 286
122
osurg
Acute after
bdural -74 d PC bdural enesis apy J
ent of 500
istics and
okyo)
et al bdural World
rebral hronic Scand
et al atoma cified
Clin
Fu-J
Meng
FIG
Figu
Figu
Jen Journal o
g-Chi Lin Ju
GURES
ure 1 Axial vi
poropar
ure 2 Axial v
my wit
cute sub
of Medicine V
i-Ming Sun Y
iew of CT rev
rietal region d
iew of subseq
th closed-syste
bdural hemorr
Vol 3 No 4 2
Acute intram
Yu-Hao Chen
vealing a layer
displaying a m
quent CT scan
em drainage (
rhage in the ri
2020
membranous
Cheng-Ta Hs
red type of CS
midline shift
ns (A) Bone w
(white arrow)
ight frontal re
hemorrhage
ieh
SDH (white ar
window view
and (B) Soft
gion (white ar
rrow) in the rig
showed the b
tissue windo
rrow)
ght frontotem
burr hole crani
ow showed hy
123
m-
iosto-
ypera-
Fu-J
Meng
Figu
Jen Journal o
g-Chi Lin Ju
ure 3 Intraop
brane
the fro
of Medicine V
i-Ming Sun Y
perative photo
(white arrow)
ntal region to
Vol 3 No 4 2
Acute intram
Yu-Hao Chen
o revealing ac
) and inner m
the previous b
2020
membranous
Cheng-Ta Hs
cute intramem
membrane (wh
burr hole cran
hemorrhage
ieh
mbranous hem
hite asterisk) o
niostomy site
morrhage withi
of the hemato
(white triangl
in the outer m
oma situated
le)
124
mem-
from
Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh
125
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
慢性硬腦膜下出血進行鑽顱引流手術造成超急性夾膜內出
血
林孟楫 1孫瑞明 23陳昱豪 24謝政達 567
中文摘要
鑽顱併封閉系統引流手術是治療慢性硬腦膜下出血患者一種有效且常見的
神經外科手術方式術後出血可能導致神經功能缺損惡化是眾所周知但不常見
的併發症之一然而至今仍未有鑽孔併封閉系統引流造成原本慢性硬腦膜血
塊內膜和外膜間急性夾膜間出血案例在這裡我們報告一例慢性硬腦膜下出
血病患者接受鑽顱併封閉系統引流手術治療造成術後急性夾膜間出血我們在
本文中討論可能的致病機制並回顧相關文獻
關鍵字慢性硬腦膜下出血急性硬腦膜下出血出血鑽顱術引流
1國軍高雄總醫院左營分院 外科部
2崇仁醫護管理專科學校
3亞洲大學 生物科技學系
4戴德森醫療財團法人嘉義基督教醫院 外科部 神經外科
5汐止國泰綜合醫院 神經外科
6輔仁大學 醫學系
7 國防醫學院 三軍總醫院 神經外科
通訊作者謝政達 電子信箱 nogormail2000comtw
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
126
Submitted January 21 2020
Final version accepted July 08
2020
Case Report
Hamartoma of the breast A case report
Cite as Hsuan-An Chen
Cheng-Yu Lo Shih-Hung Huang
Chin-Lung Lin
Hamartoma of the breast A case
report Fu-Jen Journal of Medicine
3(5) 126-130 2020
DOI
103966181020932020091803005
Hsuan-An Chen1 Cheng-Yu Lo
3 Shih-Hung Huang
3 Chin-Lung
Lin2
1Department of Surgery Cathay General Hospital Taipei Taiwan
2Department of General Surgery Cathay General Hospital Taipei Tai-
wan
3Department of Pathology Cathay General Hospital Taipei Taiwan
Corresponding author E-mail address
lungyungmailcom (Chin-Lung Lin)
ABSTRACT
Breast hamartoma is an uncommon benign tumor rarely associated with malignancy An
excision and histological examination is necessary for the differential diagnosis We report
a case of a 49-year-old female patient presenting with a lump in the right breast Ultrasound
examination which demonstrated a 4411 cm hypoechoic lesion with lipoma Partial mas-
tectomy was arranged and the diagnosis of a hamartoma was confirmed by the histological
examination
Keywords Breast tumor Hamartoma Ultrasound
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
127
INTRODUCTION The hamartoma is a benign tumor-like lesion
that can affect various organs of the body in-
cluding lungs kidneys skin and more rarely the
breast In 1981 the hamartomas were recognized
in the WHO classification[1] They are defined
as well-demarcated mass of mammary ducts and
lobules containing varying amounts of fibrous
and adipose tissue and producing a distinctive
mammographic image
CASE REPORT A 49 year-old female had past history of left
breast mastitis with abscess status post partial
mastectomy This time she presented to our out
patient clinic for breast examination Physical
examination revealed a painless palpable mova-
ble and painless lump at upper outer quadrant of
right breast The risk of breast cancer was not
noted and the patient did not have any family
history of breast cancer The patient also denied
any trauma history before Ultrasound examina-
tion was arranged which demonstrated a 4411
cm hypoechoic lesion with lipoma at 3 oclock 2
cm from nipple of right breast and multiple hy-
poechoic nodules of various size in both breasts
and there was no suspicious axillary lymph
nodes noted (Figure1) Surgical treatment was
arranged partial mastectomy of right breast
harmartoma was successfully performed A 32 x
31 x 21 cm tumor was completely excised
Grossly examination showed a gray to yellow
and firm to fatty The diagnosis of a hamartoma
was confirmed by the histological examination
Microscopically sections of the breast lesion
show mammary hamartoma composed of ducts
lobules with interlobular fibrous tissue and adi-
pose tissue Fibrocystic change apocrine meta-
plastic ducts and scattered foci of adenosis are
noted The overall lobulocentric architecture and
the 2-cell pattern of the epithelium are preserved
columnar cell change and focal microcalcifica-
tion are present (Figure2) Based on submitted
biopsy specimen in-situ or invasive tumor cells
are not identified
DISCUSSION Hamartoma of the breast is a benign tumor like
nodule it was also known as fibroadenolipoma
lipofibroadenoma or adenolipoma based on its
predominant components It was composed of
varying amounts of glandular adipose and fi-
brous tissue[2] Hamartomas were first described
in 1971 by Arrigoni et al in a study of 10 patients
which breast tumors clinically and grossly re-
sembled fibroadenomas[3]
A higher predominance of tumors exists in fe-
males compared with males Hamartomas are
slowly-growing lesions with the diameter rang-
ing from 2 cm to 5 cm sometimes hamartomas
can reach giant diameter [4]
The clinical diagnosis of hamartoma is based on
the findings from mammography sonography
and histology examinations The hamartomas are
usually incidentally diagnosed by the women
older than 40 year-old starting mammography
screening
On physicial examination harmatomas are usu-
ally occult painless they may be as large mo-
bile soft to firm masses[5] Ultrasound showed
well capsulated mass with echogenic rim and
internal heterogeneity Mammography exam
showed well-circumscribed round to oval
masses containing fat and soft tissue densities
with a thin radiopaque pseudocapsule The
pseudocapsule results from displacement of
breast parenchyma by the tumor [56] In Pa-
thology finding microglandular adenosis is pre-
sent in fibroadipose stroma surrounded by a thin
fibrous capsule It composed of a combination of
epithelial and stromal elements usually with
normal ducts or lobules although variations of
normal tissue may also be seen Fibroadenoli-
poma myoid hamartoma and chondrolipoma are
histological variations of hamartomas depend-
ing on the proportion of normal breast tissue
elements[7]
Malignancy associated with hamartomas are
very rare[8] However it has been reported
hamartomas develop into carcinoma Malignant
transformation can occur as a result of cellular
atypia in the epithelial component of the mass[9]
Surgical removal is the curative method for
breast hamartomas[10] Diagnostic material such
as mammography ultrasonography or core nee-
dle biopsy may not give the definitive diagnosis
Therefore surgical excision and histological
examination is necessary for differential diagno-
sis[111213]
Although it is rare hamartoma can be seen along
with malignancy as it is formed from similar
components of breast tissue Therefore careful
diagnosis and appropriate management including
surgery are required
REFERENCES 1 World Health Organization (1981)
Histological typing of breast tumors In
International histological classification of
tumors 1981 2nd ed
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
128
2 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11435ndash449
2006
3 ArrigoniMG DockertyMB JuddES
The identificationand treatment of
mammary hamartoma Surg Gynecol
Obstet1971 133 577-82
4 Sanal HT Ersoz N Altinel O Unal E Can
C Giant hamartoma of the breast Breast J
2006 12 84-85
5 Feder JM de Paredes ES Hogge JP
Wilken JJ Unusual breast lesions
radiologic-pathologic correlation
Radiographics 1999 19S11ndashS26
6 Murat A Ozdemir H Yildirim H Poyraz
AK Ozercan R Hamartoma of the breast
Australas Radiol 200751 Spec NoB37ndash
9
7 Fisher CJ Hanby AM Robinson L Millis
RR Mammary hamartoma-a review of 35
cases Histopathology 1992 20 99-106
8 Choi N Ko ES Invasive ductal carcinoma
in a mammary hamartoma case report and
review of the literature Korean J Radiol
2010 Nov-Dec11(6)687-91
9 Lee EH Wylie EJ Bourke AG Bastiaan
De Boer W Invasive ductal carcinoma
arising in a breast hamartoma two case
reports and a review of the literature Clin
Radiol 2003 58 80-3
10 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11 435 ‑449
2006
11 Coyne J Hobbs FM Boggis C Harland R
Lobular carcinoma in a mammary
hamartoma J Clin Pathol 199245936ndash
937
12 G M K Tse B K B Law T K F Ma A B W
Chan Hamartoma of the breast a
clinicopathological review J Clin Pathol
200255951ndash954
13 RAAmir SSheikh BreasthamartomaA
report of 14cases of an under-recognized
and under-reported entity International
Journal of Surgery Case Reports
22(2016)1ndash4
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
129
FIGURES
Figure 1 Ultrasound shows a 4411 cm hypoechoic lesion with lipoma at 3 oclock 2 cm from nipple
of right breast
Figure 2 Photomicrograph shows mammary hamartoma composed of ducts lobules with interlobular
fibrous tissue and adipose tissue
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
130
Hamartoma of the breast A case report
乳房錯構瘤罕見個案報告
陳宣安 1羅承裕 3黃世鴻 3林錦龍 2
中文摘要
乳房錯構瘤是一種罕見之乳房良性腫瘤切除手術及病理化驗來做鑑別診斷
我們報告一位 49歲女性以可觸摸到無痛性右側乳房腫塊為臨床表徵超音波
看到一個邊緣清楚低迴音的腫塊病患接受手術切除病灶病理診斷證實為乳
房錯構瘤
關鍵字乳房腫瘤錯構瘤超音波攝影
1國泰綜合醫院外科部
2國泰綜合醫院一般外科
3國泰綜合醫院病理科
通訊作者林錦龍 電子信箱 lungyungmailcom
Fu-Jen Journal of Medicine
Mission and Goals
The Fu-Jen Journal of Medicine (FJJM) is a peer-reviewed journal which
aims to enhance research quality of staffs in the College of Medicine Fu Jen
Catholic University The journal publishes original investigations across a
wide range of medical disciplines including original research articles in basic
and clinical sciences case reports review articles brief reports and letter
to the editor FJJM is now issued by the Center of Medical Education in the
College of Medicine Fu Jen Catholic University To promote journal quality
the manuscript submitted to FJJM after August first 2015 has to be prepared
in English to meet the international standards
Issue Date
Publication Date
Institution
December 01 2003
September 30 2020
College of Medicine Fu Jen Catholic University
Honorable publisher Han-Sun Chiang
Publisher Ping-Keung Yip
Editor-in-chief Ming-Chieh Ma
Associate Editors Yu-Wen Lin
Editors
Telephone (02) 2905-3477
Address Center for Medical Education College of Medicine Fu Jen
Catholic University
No 510 Zhongzheng Rd Xinzhuang Dist New Taipei City
24205 Taiwan
Su-Jane Wang Chi-Chung Wang Chih-Ming Ho
Yih-Jing Lee Chih-Shung Wong Tze-Wah Kao
Chi-Feng Hung Rung-Fen Feng Chee-Fah Chogn
Chia-Chen Lu Zai-Ting Yeh
Dee Pei Chih-Kuang Liu
Hen-Hui Lien Chien-Hsiou Liu
Chun-Hou Liao Yi-Ju Tsai Sheng-Wen Teng
Chia-Ting Su
- 9月封面
- 9月目錄頁
- 2020九月刊排版NO1_完稿
- 2020九月刊排版NO2_完稿
- 2020九月刊排版NO3_完稿
- 2020九月刊排版NO4_完稿
- 2020九月刊排版NO5_完稿
- 版權頁(SEP)
- 9月封底
-
Fu-J
Meng
FIG
Figu
Figu
Jen Journal o
g-Chi Lin Ju
GURES
ure 1 Axial vi
poropar
ure 2 Axial v
my wit
cute sub
of Medicine V
i-Ming Sun Y
iew of CT rev
rietal region d
iew of subseq
th closed-syste
bdural hemorr
Vol 3 No 4 2
Acute intram
Yu-Hao Chen
vealing a layer
displaying a m
quent CT scan
em drainage (
rhage in the ri
2020
membranous
Cheng-Ta Hs
red type of CS
midline shift
ns (A) Bone w
(white arrow)
ight frontal re
hemorrhage
ieh
SDH (white ar
window view
and (B) Soft
gion (white ar
rrow) in the rig
showed the b
tissue windo
rrow)
ght frontotem
burr hole crani
ow showed hy
123
m-
iosto-
ypera-
Fu-J
Meng
Figu
Jen Journal o
g-Chi Lin Ju
ure 3 Intraop
brane
the fro
of Medicine V
i-Ming Sun Y
perative photo
(white arrow)
ntal region to
Vol 3 No 4 2
Acute intram
Yu-Hao Chen
o revealing ac
) and inner m
the previous b
2020
membranous
Cheng-Ta Hs
cute intramem
membrane (wh
burr hole cran
hemorrhage
ieh
mbranous hem
hite asterisk) o
niostomy site
morrhage withi
of the hemato
(white triangl
in the outer m
oma situated
le)
124
mem-
from
Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh
125
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
慢性硬腦膜下出血進行鑽顱引流手術造成超急性夾膜內出
血
林孟楫 1孫瑞明 23陳昱豪 24謝政達 567
中文摘要
鑽顱併封閉系統引流手術是治療慢性硬腦膜下出血患者一種有效且常見的
神經外科手術方式術後出血可能導致神經功能缺損惡化是眾所周知但不常見
的併發症之一然而至今仍未有鑽孔併封閉系統引流造成原本慢性硬腦膜血
塊內膜和外膜間急性夾膜間出血案例在這裡我們報告一例慢性硬腦膜下出
血病患者接受鑽顱併封閉系統引流手術治療造成術後急性夾膜間出血我們在
本文中討論可能的致病機制並回顧相關文獻
關鍵字慢性硬腦膜下出血急性硬腦膜下出血出血鑽顱術引流
1國軍高雄總醫院左營分院 外科部
2崇仁醫護管理專科學校
3亞洲大學 生物科技學系
4戴德森醫療財團法人嘉義基督教醫院 外科部 神經外科
5汐止國泰綜合醫院 神經外科
6輔仁大學 醫學系
7 國防醫學院 三軍總醫院 神經外科
通訊作者謝政達 電子信箱 nogormail2000comtw
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
126
Submitted January 21 2020
Final version accepted July 08
2020
Case Report
Hamartoma of the breast A case report
Cite as Hsuan-An Chen
Cheng-Yu Lo Shih-Hung Huang
Chin-Lung Lin
Hamartoma of the breast A case
report Fu-Jen Journal of Medicine
3(5) 126-130 2020
DOI
103966181020932020091803005
Hsuan-An Chen1 Cheng-Yu Lo
3 Shih-Hung Huang
3 Chin-Lung
Lin2
1Department of Surgery Cathay General Hospital Taipei Taiwan
2Department of General Surgery Cathay General Hospital Taipei Tai-
wan
3Department of Pathology Cathay General Hospital Taipei Taiwan
Corresponding author E-mail address
lungyungmailcom (Chin-Lung Lin)
ABSTRACT
Breast hamartoma is an uncommon benign tumor rarely associated with malignancy An
excision and histological examination is necessary for the differential diagnosis We report
a case of a 49-year-old female patient presenting with a lump in the right breast Ultrasound
examination which demonstrated a 4411 cm hypoechoic lesion with lipoma Partial mas-
tectomy was arranged and the diagnosis of a hamartoma was confirmed by the histological
examination
Keywords Breast tumor Hamartoma Ultrasound
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
127
INTRODUCTION The hamartoma is a benign tumor-like lesion
that can affect various organs of the body in-
cluding lungs kidneys skin and more rarely the
breast In 1981 the hamartomas were recognized
in the WHO classification[1] They are defined
as well-demarcated mass of mammary ducts and
lobules containing varying amounts of fibrous
and adipose tissue and producing a distinctive
mammographic image
CASE REPORT A 49 year-old female had past history of left
breast mastitis with abscess status post partial
mastectomy This time she presented to our out
patient clinic for breast examination Physical
examination revealed a painless palpable mova-
ble and painless lump at upper outer quadrant of
right breast The risk of breast cancer was not
noted and the patient did not have any family
history of breast cancer The patient also denied
any trauma history before Ultrasound examina-
tion was arranged which demonstrated a 4411
cm hypoechoic lesion with lipoma at 3 oclock 2
cm from nipple of right breast and multiple hy-
poechoic nodules of various size in both breasts
and there was no suspicious axillary lymph
nodes noted (Figure1) Surgical treatment was
arranged partial mastectomy of right breast
harmartoma was successfully performed A 32 x
31 x 21 cm tumor was completely excised
Grossly examination showed a gray to yellow
and firm to fatty The diagnosis of a hamartoma
was confirmed by the histological examination
Microscopically sections of the breast lesion
show mammary hamartoma composed of ducts
lobules with interlobular fibrous tissue and adi-
pose tissue Fibrocystic change apocrine meta-
plastic ducts and scattered foci of adenosis are
noted The overall lobulocentric architecture and
the 2-cell pattern of the epithelium are preserved
columnar cell change and focal microcalcifica-
tion are present (Figure2) Based on submitted
biopsy specimen in-situ or invasive tumor cells
are not identified
DISCUSSION Hamartoma of the breast is a benign tumor like
nodule it was also known as fibroadenolipoma
lipofibroadenoma or adenolipoma based on its
predominant components It was composed of
varying amounts of glandular adipose and fi-
brous tissue[2] Hamartomas were first described
in 1971 by Arrigoni et al in a study of 10 patients
which breast tumors clinically and grossly re-
sembled fibroadenomas[3]
A higher predominance of tumors exists in fe-
males compared with males Hamartomas are
slowly-growing lesions with the diameter rang-
ing from 2 cm to 5 cm sometimes hamartomas
can reach giant diameter [4]
The clinical diagnosis of hamartoma is based on
the findings from mammography sonography
and histology examinations The hamartomas are
usually incidentally diagnosed by the women
older than 40 year-old starting mammography
screening
On physicial examination harmatomas are usu-
ally occult painless they may be as large mo-
bile soft to firm masses[5] Ultrasound showed
well capsulated mass with echogenic rim and
internal heterogeneity Mammography exam
showed well-circumscribed round to oval
masses containing fat and soft tissue densities
with a thin radiopaque pseudocapsule The
pseudocapsule results from displacement of
breast parenchyma by the tumor [56] In Pa-
thology finding microglandular adenosis is pre-
sent in fibroadipose stroma surrounded by a thin
fibrous capsule It composed of a combination of
epithelial and stromal elements usually with
normal ducts or lobules although variations of
normal tissue may also be seen Fibroadenoli-
poma myoid hamartoma and chondrolipoma are
histological variations of hamartomas depend-
ing on the proportion of normal breast tissue
elements[7]
Malignancy associated with hamartomas are
very rare[8] However it has been reported
hamartomas develop into carcinoma Malignant
transformation can occur as a result of cellular
atypia in the epithelial component of the mass[9]
Surgical removal is the curative method for
breast hamartomas[10] Diagnostic material such
as mammography ultrasonography or core nee-
dle biopsy may not give the definitive diagnosis
Therefore surgical excision and histological
examination is necessary for differential diagno-
sis[111213]
Although it is rare hamartoma can be seen along
with malignancy as it is formed from similar
components of breast tissue Therefore careful
diagnosis and appropriate management including
surgery are required
REFERENCES 1 World Health Organization (1981)
Histological typing of breast tumors In
International histological classification of
tumors 1981 2nd ed
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
128
2 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11435ndash449
2006
3 ArrigoniMG DockertyMB JuddES
The identificationand treatment of
mammary hamartoma Surg Gynecol
Obstet1971 133 577-82
4 Sanal HT Ersoz N Altinel O Unal E Can
C Giant hamartoma of the breast Breast J
2006 12 84-85
5 Feder JM de Paredes ES Hogge JP
Wilken JJ Unusual breast lesions
radiologic-pathologic correlation
Radiographics 1999 19S11ndashS26
6 Murat A Ozdemir H Yildirim H Poyraz
AK Ozercan R Hamartoma of the breast
Australas Radiol 200751 Spec NoB37ndash
9
7 Fisher CJ Hanby AM Robinson L Millis
RR Mammary hamartoma-a review of 35
cases Histopathology 1992 20 99-106
8 Choi N Ko ES Invasive ductal carcinoma
in a mammary hamartoma case report and
review of the literature Korean J Radiol
2010 Nov-Dec11(6)687-91
9 Lee EH Wylie EJ Bourke AG Bastiaan
De Boer W Invasive ductal carcinoma
arising in a breast hamartoma two case
reports and a review of the literature Clin
Radiol 2003 58 80-3
10 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11 435 ‑449
2006
11 Coyne J Hobbs FM Boggis C Harland R
Lobular carcinoma in a mammary
hamartoma J Clin Pathol 199245936ndash
937
12 G M K Tse B K B Law T K F Ma A B W
Chan Hamartoma of the breast a
clinicopathological review J Clin Pathol
200255951ndash954
13 RAAmir SSheikh BreasthamartomaA
report of 14cases of an under-recognized
and under-reported entity International
Journal of Surgery Case Reports
22(2016)1ndash4
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
129
FIGURES
Figure 1 Ultrasound shows a 4411 cm hypoechoic lesion with lipoma at 3 oclock 2 cm from nipple
of right breast
Figure 2 Photomicrograph shows mammary hamartoma composed of ducts lobules with interlobular
fibrous tissue and adipose tissue
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
130
Hamartoma of the breast A case report
乳房錯構瘤罕見個案報告
陳宣安 1羅承裕 3黃世鴻 3林錦龍 2
中文摘要
乳房錯構瘤是一種罕見之乳房良性腫瘤切除手術及病理化驗來做鑑別診斷
我們報告一位 49歲女性以可觸摸到無痛性右側乳房腫塊為臨床表徵超音波
看到一個邊緣清楚低迴音的腫塊病患接受手術切除病灶病理診斷證實為乳
房錯構瘤
關鍵字乳房腫瘤錯構瘤超音波攝影
1國泰綜合醫院外科部
2國泰綜合醫院一般外科
3國泰綜合醫院病理科
通訊作者林錦龍 電子信箱 lungyungmailcom
Fu-Jen Journal of Medicine
Mission and Goals
The Fu-Jen Journal of Medicine (FJJM) is a peer-reviewed journal which
aims to enhance research quality of staffs in the College of Medicine Fu Jen
Catholic University The journal publishes original investigations across a
wide range of medical disciplines including original research articles in basic
and clinical sciences case reports review articles brief reports and letter
to the editor FJJM is now issued by the Center of Medical Education in the
College of Medicine Fu Jen Catholic University To promote journal quality
the manuscript submitted to FJJM after August first 2015 has to be prepared
in English to meet the international standards
Issue Date
Publication Date
Institution
December 01 2003
September 30 2020
College of Medicine Fu Jen Catholic University
Honorable publisher Han-Sun Chiang
Publisher Ping-Keung Yip
Editor-in-chief Ming-Chieh Ma
Associate Editors Yu-Wen Lin
Editors
Telephone (02) 2905-3477
Address Center for Medical Education College of Medicine Fu Jen
Catholic University
No 510 Zhongzheng Rd Xinzhuang Dist New Taipei City
24205 Taiwan
Su-Jane Wang Chi-Chung Wang Chih-Ming Ho
Yih-Jing Lee Chih-Shung Wong Tze-Wah Kao
Chi-Feng Hung Rung-Fen Feng Chee-Fah Chogn
Chia-Chen Lu Zai-Ting Yeh
Dee Pei Chih-Kuang Liu
Hen-Hui Lien Chien-Hsiou Liu
Chun-Hou Liao Yi-Ju Tsai Sheng-Wen Teng
Chia-Ting Su
- 9月封面
- 9月目錄頁
- 2020九月刊排版NO1_完稿
- 2020九月刊排版NO2_完稿
- 2020九月刊排版NO3_完稿
- 2020九月刊排版NO4_完稿
- 2020九月刊排版NO5_完稿
- 版權頁(SEP)
- 9月封底
-
Fu-J
Meng
Figu
Jen Journal o
g-Chi Lin Ju
ure 3 Intraop
brane
the fro
of Medicine V
i-Ming Sun Y
perative photo
(white arrow)
ntal region to
Vol 3 No 4 2
Acute intram
Yu-Hao Chen
o revealing ac
) and inner m
the previous b
2020
membranous
Cheng-Ta Hs
cute intramem
membrane (wh
burr hole cran
hemorrhage
ieh
mbranous hem
hite asterisk) o
niostomy site
morrhage withi
of the hemato
(white triangl
in the outer m
oma situated
le)
124
mem-
from
Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh
125
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
慢性硬腦膜下出血進行鑽顱引流手術造成超急性夾膜內出
血
林孟楫 1孫瑞明 23陳昱豪 24謝政達 567
中文摘要
鑽顱併封閉系統引流手術是治療慢性硬腦膜下出血患者一種有效且常見的
神經外科手術方式術後出血可能導致神經功能缺損惡化是眾所周知但不常見
的併發症之一然而至今仍未有鑽孔併封閉系統引流造成原本慢性硬腦膜血
塊內膜和外膜間急性夾膜間出血案例在這裡我們報告一例慢性硬腦膜下出
血病患者接受鑽顱併封閉系統引流手術治療造成術後急性夾膜間出血我們在
本文中討論可能的致病機制並回顧相關文獻
關鍵字慢性硬腦膜下出血急性硬腦膜下出血出血鑽顱術引流
1國軍高雄總醫院左營分院 外科部
2崇仁醫護管理專科學校
3亞洲大學 生物科技學系
4戴德森醫療財團法人嘉義基督教醫院 外科部 神經外科
5汐止國泰綜合醫院 神經外科
6輔仁大學 醫學系
7 國防醫學院 三軍總醫院 神經外科
通訊作者謝政達 電子信箱 nogormail2000comtw
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
126
Submitted January 21 2020
Final version accepted July 08
2020
Case Report
Hamartoma of the breast A case report
Cite as Hsuan-An Chen
Cheng-Yu Lo Shih-Hung Huang
Chin-Lung Lin
Hamartoma of the breast A case
report Fu-Jen Journal of Medicine
3(5) 126-130 2020
DOI
103966181020932020091803005
Hsuan-An Chen1 Cheng-Yu Lo
3 Shih-Hung Huang
3 Chin-Lung
Lin2
1Department of Surgery Cathay General Hospital Taipei Taiwan
2Department of General Surgery Cathay General Hospital Taipei Tai-
wan
3Department of Pathology Cathay General Hospital Taipei Taiwan
Corresponding author E-mail address
lungyungmailcom (Chin-Lung Lin)
ABSTRACT
Breast hamartoma is an uncommon benign tumor rarely associated with malignancy An
excision and histological examination is necessary for the differential diagnosis We report
a case of a 49-year-old female patient presenting with a lump in the right breast Ultrasound
examination which demonstrated a 4411 cm hypoechoic lesion with lipoma Partial mas-
tectomy was arranged and the diagnosis of a hamartoma was confirmed by the histological
examination
Keywords Breast tumor Hamartoma Ultrasound
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
127
INTRODUCTION The hamartoma is a benign tumor-like lesion
that can affect various organs of the body in-
cluding lungs kidneys skin and more rarely the
breast In 1981 the hamartomas were recognized
in the WHO classification[1] They are defined
as well-demarcated mass of mammary ducts and
lobules containing varying amounts of fibrous
and adipose tissue and producing a distinctive
mammographic image
CASE REPORT A 49 year-old female had past history of left
breast mastitis with abscess status post partial
mastectomy This time she presented to our out
patient clinic for breast examination Physical
examination revealed a painless palpable mova-
ble and painless lump at upper outer quadrant of
right breast The risk of breast cancer was not
noted and the patient did not have any family
history of breast cancer The patient also denied
any trauma history before Ultrasound examina-
tion was arranged which demonstrated a 4411
cm hypoechoic lesion with lipoma at 3 oclock 2
cm from nipple of right breast and multiple hy-
poechoic nodules of various size in both breasts
and there was no suspicious axillary lymph
nodes noted (Figure1) Surgical treatment was
arranged partial mastectomy of right breast
harmartoma was successfully performed A 32 x
31 x 21 cm tumor was completely excised
Grossly examination showed a gray to yellow
and firm to fatty The diagnosis of a hamartoma
was confirmed by the histological examination
Microscopically sections of the breast lesion
show mammary hamartoma composed of ducts
lobules with interlobular fibrous tissue and adi-
pose tissue Fibrocystic change apocrine meta-
plastic ducts and scattered foci of adenosis are
noted The overall lobulocentric architecture and
the 2-cell pattern of the epithelium are preserved
columnar cell change and focal microcalcifica-
tion are present (Figure2) Based on submitted
biopsy specimen in-situ or invasive tumor cells
are not identified
DISCUSSION Hamartoma of the breast is a benign tumor like
nodule it was also known as fibroadenolipoma
lipofibroadenoma or adenolipoma based on its
predominant components It was composed of
varying amounts of glandular adipose and fi-
brous tissue[2] Hamartomas were first described
in 1971 by Arrigoni et al in a study of 10 patients
which breast tumors clinically and grossly re-
sembled fibroadenomas[3]
A higher predominance of tumors exists in fe-
males compared with males Hamartomas are
slowly-growing lesions with the diameter rang-
ing from 2 cm to 5 cm sometimes hamartomas
can reach giant diameter [4]
The clinical diagnosis of hamartoma is based on
the findings from mammography sonography
and histology examinations The hamartomas are
usually incidentally diagnosed by the women
older than 40 year-old starting mammography
screening
On physicial examination harmatomas are usu-
ally occult painless they may be as large mo-
bile soft to firm masses[5] Ultrasound showed
well capsulated mass with echogenic rim and
internal heterogeneity Mammography exam
showed well-circumscribed round to oval
masses containing fat and soft tissue densities
with a thin radiopaque pseudocapsule The
pseudocapsule results from displacement of
breast parenchyma by the tumor [56] In Pa-
thology finding microglandular adenosis is pre-
sent in fibroadipose stroma surrounded by a thin
fibrous capsule It composed of a combination of
epithelial and stromal elements usually with
normal ducts or lobules although variations of
normal tissue may also be seen Fibroadenoli-
poma myoid hamartoma and chondrolipoma are
histological variations of hamartomas depend-
ing on the proportion of normal breast tissue
elements[7]
Malignancy associated with hamartomas are
very rare[8] However it has been reported
hamartomas develop into carcinoma Malignant
transformation can occur as a result of cellular
atypia in the epithelial component of the mass[9]
Surgical removal is the curative method for
breast hamartomas[10] Diagnostic material such
as mammography ultrasonography or core nee-
dle biopsy may not give the definitive diagnosis
Therefore surgical excision and histological
examination is necessary for differential diagno-
sis[111213]
Although it is rare hamartoma can be seen along
with malignancy as it is formed from similar
components of breast tissue Therefore careful
diagnosis and appropriate management including
surgery are required
REFERENCES 1 World Health Organization (1981)
Histological typing of breast tumors In
International histological classification of
tumors 1981 2nd ed
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
128
2 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11435ndash449
2006
3 ArrigoniMG DockertyMB JuddES
The identificationand treatment of
mammary hamartoma Surg Gynecol
Obstet1971 133 577-82
4 Sanal HT Ersoz N Altinel O Unal E Can
C Giant hamartoma of the breast Breast J
2006 12 84-85
5 Feder JM de Paredes ES Hogge JP
Wilken JJ Unusual breast lesions
radiologic-pathologic correlation
Radiographics 1999 19S11ndashS26
6 Murat A Ozdemir H Yildirim H Poyraz
AK Ozercan R Hamartoma of the breast
Australas Radiol 200751 Spec NoB37ndash
9
7 Fisher CJ Hanby AM Robinson L Millis
RR Mammary hamartoma-a review of 35
cases Histopathology 1992 20 99-106
8 Choi N Ko ES Invasive ductal carcinoma
in a mammary hamartoma case report and
review of the literature Korean J Radiol
2010 Nov-Dec11(6)687-91
9 Lee EH Wylie EJ Bourke AG Bastiaan
De Boer W Invasive ductal carcinoma
arising in a breast hamartoma two case
reports and a review of the literature Clin
Radiol 2003 58 80-3
10 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11 435 ‑449
2006
11 Coyne J Hobbs FM Boggis C Harland R
Lobular carcinoma in a mammary
hamartoma J Clin Pathol 199245936ndash
937
12 G M K Tse B K B Law T K F Ma A B W
Chan Hamartoma of the breast a
clinicopathological review J Clin Pathol
200255951ndash954
13 RAAmir SSheikh BreasthamartomaA
report of 14cases of an under-recognized
and under-reported entity International
Journal of Surgery Case Reports
22(2016)1ndash4
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
129
FIGURES
Figure 1 Ultrasound shows a 4411 cm hypoechoic lesion with lipoma at 3 oclock 2 cm from nipple
of right breast
Figure 2 Photomicrograph shows mammary hamartoma composed of ducts lobules with interlobular
fibrous tissue and adipose tissue
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
130
Hamartoma of the breast A case report
乳房錯構瘤罕見個案報告
陳宣安 1羅承裕 3黃世鴻 3林錦龍 2
中文摘要
乳房錯構瘤是一種罕見之乳房良性腫瘤切除手術及病理化驗來做鑑別診斷
我們報告一位 49歲女性以可觸摸到無痛性右側乳房腫塊為臨床表徵超音波
看到一個邊緣清楚低迴音的腫塊病患接受手術切除病灶病理診斷證實為乳
房錯構瘤
關鍵字乳房腫瘤錯構瘤超音波攝影
1國泰綜合醫院外科部
2國泰綜合醫院一般外科
3國泰綜合醫院病理科
通訊作者林錦龍 電子信箱 lungyungmailcom
Fu-Jen Journal of Medicine
Mission and Goals
The Fu-Jen Journal of Medicine (FJJM) is a peer-reviewed journal which
aims to enhance research quality of staffs in the College of Medicine Fu Jen
Catholic University The journal publishes original investigations across a
wide range of medical disciplines including original research articles in basic
and clinical sciences case reports review articles brief reports and letter
to the editor FJJM is now issued by the Center of Medical Education in the
College of Medicine Fu Jen Catholic University To promote journal quality
the manuscript submitted to FJJM after August first 2015 has to be prepared
in English to meet the international standards
Issue Date
Publication Date
Institution
December 01 2003
September 30 2020
College of Medicine Fu Jen Catholic University
Honorable publisher Han-Sun Chiang
Publisher Ping-Keung Yip
Editor-in-chief Ming-Chieh Ma
Associate Editors Yu-Wen Lin
Editors
Telephone (02) 2905-3477
Address Center for Medical Education College of Medicine Fu Jen
Catholic University
No 510 Zhongzheng Rd Xinzhuang Dist New Taipei City
24205 Taiwan
Su-Jane Wang Chi-Chung Wang Chih-Ming Ho
Yih-Jing Lee Chih-Shung Wong Tze-Wah Kao
Chi-Feng Hung Rung-Fen Feng Chee-Fah Chogn
Chia-Chen Lu Zai-Ting Yeh
Dee Pei Chih-Kuang Liu
Hen-Hui Lien Chien-Hsiou Liu
Chun-Hou Liao Yi-Ju Tsai Sheng-Wen Teng
Chia-Ting Su
- 9月封面
- 9月目錄頁
- 2020九月刊排版NO1_完稿
- 2020九月刊排版NO2_完稿
- 2020九月刊排版NO3_完稿
- 2020九月刊排版NO4_完稿
- 2020九月刊排版NO5_完稿
- 版權頁(SEP)
- 9月封底
-
Fu-Jen Journal of Medicine Vol 3 No 4 2020
Acute intramembranous hemorrhage
Meng-Chi Lin Jui-Ming Sun Yu-Hao Chen Cheng-Ta Hsieh
125
Human Factors Underlying Adverse Medical Events Revisit Root Cause Analysis
Cases Using the HFACS
慢性硬腦膜下出血進行鑽顱引流手術造成超急性夾膜內出
血
林孟楫 1孫瑞明 23陳昱豪 24謝政達 567
中文摘要
鑽顱併封閉系統引流手術是治療慢性硬腦膜下出血患者一種有效且常見的
神經外科手術方式術後出血可能導致神經功能缺損惡化是眾所周知但不常見
的併發症之一然而至今仍未有鑽孔併封閉系統引流造成原本慢性硬腦膜血
塊內膜和外膜間急性夾膜間出血案例在這裡我們報告一例慢性硬腦膜下出
血病患者接受鑽顱併封閉系統引流手術治療造成術後急性夾膜間出血我們在
本文中討論可能的致病機制並回顧相關文獻
關鍵字慢性硬腦膜下出血急性硬腦膜下出血出血鑽顱術引流
1國軍高雄總醫院左營分院 外科部
2崇仁醫護管理專科學校
3亞洲大學 生物科技學系
4戴德森醫療財團法人嘉義基督教醫院 外科部 神經外科
5汐止國泰綜合醫院 神經外科
6輔仁大學 醫學系
7 國防醫學院 三軍總醫院 神經外科
通訊作者謝政達 電子信箱 nogormail2000comtw
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
126
Submitted January 21 2020
Final version accepted July 08
2020
Case Report
Hamartoma of the breast A case report
Cite as Hsuan-An Chen
Cheng-Yu Lo Shih-Hung Huang
Chin-Lung Lin
Hamartoma of the breast A case
report Fu-Jen Journal of Medicine
3(5) 126-130 2020
DOI
103966181020932020091803005
Hsuan-An Chen1 Cheng-Yu Lo
3 Shih-Hung Huang
3 Chin-Lung
Lin2
1Department of Surgery Cathay General Hospital Taipei Taiwan
2Department of General Surgery Cathay General Hospital Taipei Tai-
wan
3Department of Pathology Cathay General Hospital Taipei Taiwan
Corresponding author E-mail address
lungyungmailcom (Chin-Lung Lin)
ABSTRACT
Breast hamartoma is an uncommon benign tumor rarely associated with malignancy An
excision and histological examination is necessary for the differential diagnosis We report
a case of a 49-year-old female patient presenting with a lump in the right breast Ultrasound
examination which demonstrated a 4411 cm hypoechoic lesion with lipoma Partial mas-
tectomy was arranged and the diagnosis of a hamartoma was confirmed by the histological
examination
Keywords Breast tumor Hamartoma Ultrasound
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
127
INTRODUCTION The hamartoma is a benign tumor-like lesion
that can affect various organs of the body in-
cluding lungs kidneys skin and more rarely the
breast In 1981 the hamartomas were recognized
in the WHO classification[1] They are defined
as well-demarcated mass of mammary ducts and
lobules containing varying amounts of fibrous
and adipose tissue and producing a distinctive
mammographic image
CASE REPORT A 49 year-old female had past history of left
breast mastitis with abscess status post partial
mastectomy This time she presented to our out
patient clinic for breast examination Physical
examination revealed a painless palpable mova-
ble and painless lump at upper outer quadrant of
right breast The risk of breast cancer was not
noted and the patient did not have any family
history of breast cancer The patient also denied
any trauma history before Ultrasound examina-
tion was arranged which demonstrated a 4411
cm hypoechoic lesion with lipoma at 3 oclock 2
cm from nipple of right breast and multiple hy-
poechoic nodules of various size in both breasts
and there was no suspicious axillary lymph
nodes noted (Figure1) Surgical treatment was
arranged partial mastectomy of right breast
harmartoma was successfully performed A 32 x
31 x 21 cm tumor was completely excised
Grossly examination showed a gray to yellow
and firm to fatty The diagnosis of a hamartoma
was confirmed by the histological examination
Microscopically sections of the breast lesion
show mammary hamartoma composed of ducts
lobules with interlobular fibrous tissue and adi-
pose tissue Fibrocystic change apocrine meta-
plastic ducts and scattered foci of adenosis are
noted The overall lobulocentric architecture and
the 2-cell pattern of the epithelium are preserved
columnar cell change and focal microcalcifica-
tion are present (Figure2) Based on submitted
biopsy specimen in-situ or invasive tumor cells
are not identified
DISCUSSION Hamartoma of the breast is a benign tumor like
nodule it was also known as fibroadenolipoma
lipofibroadenoma or adenolipoma based on its
predominant components It was composed of
varying amounts of glandular adipose and fi-
brous tissue[2] Hamartomas were first described
in 1971 by Arrigoni et al in a study of 10 patients
which breast tumors clinically and grossly re-
sembled fibroadenomas[3]
A higher predominance of tumors exists in fe-
males compared with males Hamartomas are
slowly-growing lesions with the diameter rang-
ing from 2 cm to 5 cm sometimes hamartomas
can reach giant diameter [4]
The clinical diagnosis of hamartoma is based on
the findings from mammography sonography
and histology examinations The hamartomas are
usually incidentally diagnosed by the women
older than 40 year-old starting mammography
screening
On physicial examination harmatomas are usu-
ally occult painless they may be as large mo-
bile soft to firm masses[5] Ultrasound showed
well capsulated mass with echogenic rim and
internal heterogeneity Mammography exam
showed well-circumscribed round to oval
masses containing fat and soft tissue densities
with a thin radiopaque pseudocapsule The
pseudocapsule results from displacement of
breast parenchyma by the tumor [56] In Pa-
thology finding microglandular adenosis is pre-
sent in fibroadipose stroma surrounded by a thin
fibrous capsule It composed of a combination of
epithelial and stromal elements usually with
normal ducts or lobules although variations of
normal tissue may also be seen Fibroadenoli-
poma myoid hamartoma and chondrolipoma are
histological variations of hamartomas depend-
ing on the proportion of normal breast tissue
elements[7]
Malignancy associated with hamartomas are
very rare[8] However it has been reported
hamartomas develop into carcinoma Malignant
transformation can occur as a result of cellular
atypia in the epithelial component of the mass[9]
Surgical removal is the curative method for
breast hamartomas[10] Diagnostic material such
as mammography ultrasonography or core nee-
dle biopsy may not give the definitive diagnosis
Therefore surgical excision and histological
examination is necessary for differential diagno-
sis[111213]
Although it is rare hamartoma can be seen along
with malignancy as it is formed from similar
components of breast tissue Therefore careful
diagnosis and appropriate management including
surgery are required
REFERENCES 1 World Health Organization (1981)
Histological typing of breast tumors In
International histological classification of
tumors 1981 2nd ed
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
128
2 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11435ndash449
2006
3 ArrigoniMG DockertyMB JuddES
The identificationand treatment of
mammary hamartoma Surg Gynecol
Obstet1971 133 577-82
4 Sanal HT Ersoz N Altinel O Unal E Can
C Giant hamartoma of the breast Breast J
2006 12 84-85
5 Feder JM de Paredes ES Hogge JP
Wilken JJ Unusual breast lesions
radiologic-pathologic correlation
Radiographics 1999 19S11ndashS26
6 Murat A Ozdemir H Yildirim H Poyraz
AK Ozercan R Hamartoma of the breast
Australas Radiol 200751 Spec NoB37ndash
9
7 Fisher CJ Hanby AM Robinson L Millis
RR Mammary hamartoma-a review of 35
cases Histopathology 1992 20 99-106
8 Choi N Ko ES Invasive ductal carcinoma
in a mammary hamartoma case report and
review of the literature Korean J Radiol
2010 Nov-Dec11(6)687-91
9 Lee EH Wylie EJ Bourke AG Bastiaan
De Boer W Invasive ductal carcinoma
arising in a breast hamartoma two case
reports and a review of the literature Clin
Radiol 2003 58 80-3
10 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11 435 ‑449
2006
11 Coyne J Hobbs FM Boggis C Harland R
Lobular carcinoma in a mammary
hamartoma J Clin Pathol 199245936ndash
937
12 G M K Tse B K B Law T K F Ma A B W
Chan Hamartoma of the breast a
clinicopathological review J Clin Pathol
200255951ndash954
13 RAAmir SSheikh BreasthamartomaA
report of 14cases of an under-recognized
and under-reported entity International
Journal of Surgery Case Reports
22(2016)1ndash4
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
129
FIGURES
Figure 1 Ultrasound shows a 4411 cm hypoechoic lesion with lipoma at 3 oclock 2 cm from nipple
of right breast
Figure 2 Photomicrograph shows mammary hamartoma composed of ducts lobules with interlobular
fibrous tissue and adipose tissue
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
130
Hamartoma of the breast A case report
乳房錯構瘤罕見個案報告
陳宣安 1羅承裕 3黃世鴻 3林錦龍 2
中文摘要
乳房錯構瘤是一種罕見之乳房良性腫瘤切除手術及病理化驗來做鑑別診斷
我們報告一位 49歲女性以可觸摸到無痛性右側乳房腫塊為臨床表徵超音波
看到一個邊緣清楚低迴音的腫塊病患接受手術切除病灶病理診斷證實為乳
房錯構瘤
關鍵字乳房腫瘤錯構瘤超音波攝影
1國泰綜合醫院外科部
2國泰綜合醫院一般外科
3國泰綜合醫院病理科
通訊作者林錦龍 電子信箱 lungyungmailcom
Fu-Jen Journal of Medicine
Mission and Goals
The Fu-Jen Journal of Medicine (FJJM) is a peer-reviewed journal which
aims to enhance research quality of staffs in the College of Medicine Fu Jen
Catholic University The journal publishes original investigations across a
wide range of medical disciplines including original research articles in basic
and clinical sciences case reports review articles brief reports and letter
to the editor FJJM is now issued by the Center of Medical Education in the
College of Medicine Fu Jen Catholic University To promote journal quality
the manuscript submitted to FJJM after August first 2015 has to be prepared
in English to meet the international standards
Issue Date
Publication Date
Institution
December 01 2003
September 30 2020
College of Medicine Fu Jen Catholic University
Honorable publisher Han-Sun Chiang
Publisher Ping-Keung Yip
Editor-in-chief Ming-Chieh Ma
Associate Editors Yu-Wen Lin
Editors
Telephone (02) 2905-3477
Address Center for Medical Education College of Medicine Fu Jen
Catholic University
No 510 Zhongzheng Rd Xinzhuang Dist New Taipei City
24205 Taiwan
Su-Jane Wang Chi-Chung Wang Chih-Ming Ho
Yih-Jing Lee Chih-Shung Wong Tze-Wah Kao
Chi-Feng Hung Rung-Fen Feng Chee-Fah Chogn
Chia-Chen Lu Zai-Ting Yeh
Dee Pei Chih-Kuang Liu
Hen-Hui Lien Chien-Hsiou Liu
Chun-Hou Liao Yi-Ju Tsai Sheng-Wen Teng
Chia-Ting Su
- 9月封面
- 9月目錄頁
- 2020九月刊排版NO1_完稿
- 2020九月刊排版NO2_完稿
- 2020九月刊排版NO3_完稿
- 2020九月刊排版NO4_完稿
- 2020九月刊排版NO5_完稿
- 版權頁(SEP)
- 9月封底
-
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
126
Submitted January 21 2020
Final version accepted July 08
2020
Case Report
Hamartoma of the breast A case report
Cite as Hsuan-An Chen
Cheng-Yu Lo Shih-Hung Huang
Chin-Lung Lin
Hamartoma of the breast A case
report Fu-Jen Journal of Medicine
3(5) 126-130 2020
DOI
103966181020932020091803005
Hsuan-An Chen1 Cheng-Yu Lo
3 Shih-Hung Huang
3 Chin-Lung
Lin2
1Department of Surgery Cathay General Hospital Taipei Taiwan
2Department of General Surgery Cathay General Hospital Taipei Tai-
wan
3Department of Pathology Cathay General Hospital Taipei Taiwan
Corresponding author E-mail address
lungyungmailcom (Chin-Lung Lin)
ABSTRACT
Breast hamartoma is an uncommon benign tumor rarely associated with malignancy An
excision and histological examination is necessary for the differential diagnosis We report
a case of a 49-year-old female patient presenting with a lump in the right breast Ultrasound
examination which demonstrated a 4411 cm hypoechoic lesion with lipoma Partial mas-
tectomy was arranged and the diagnosis of a hamartoma was confirmed by the histological
examination
Keywords Breast tumor Hamartoma Ultrasound
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
127
INTRODUCTION The hamartoma is a benign tumor-like lesion
that can affect various organs of the body in-
cluding lungs kidneys skin and more rarely the
breast In 1981 the hamartomas were recognized
in the WHO classification[1] They are defined
as well-demarcated mass of mammary ducts and
lobules containing varying amounts of fibrous
and adipose tissue and producing a distinctive
mammographic image
CASE REPORT A 49 year-old female had past history of left
breast mastitis with abscess status post partial
mastectomy This time she presented to our out
patient clinic for breast examination Physical
examination revealed a painless palpable mova-
ble and painless lump at upper outer quadrant of
right breast The risk of breast cancer was not
noted and the patient did not have any family
history of breast cancer The patient also denied
any trauma history before Ultrasound examina-
tion was arranged which demonstrated a 4411
cm hypoechoic lesion with lipoma at 3 oclock 2
cm from nipple of right breast and multiple hy-
poechoic nodules of various size in both breasts
and there was no suspicious axillary lymph
nodes noted (Figure1) Surgical treatment was
arranged partial mastectomy of right breast
harmartoma was successfully performed A 32 x
31 x 21 cm tumor was completely excised
Grossly examination showed a gray to yellow
and firm to fatty The diagnosis of a hamartoma
was confirmed by the histological examination
Microscopically sections of the breast lesion
show mammary hamartoma composed of ducts
lobules with interlobular fibrous tissue and adi-
pose tissue Fibrocystic change apocrine meta-
plastic ducts and scattered foci of adenosis are
noted The overall lobulocentric architecture and
the 2-cell pattern of the epithelium are preserved
columnar cell change and focal microcalcifica-
tion are present (Figure2) Based on submitted
biopsy specimen in-situ or invasive tumor cells
are not identified
DISCUSSION Hamartoma of the breast is a benign tumor like
nodule it was also known as fibroadenolipoma
lipofibroadenoma or adenolipoma based on its
predominant components It was composed of
varying amounts of glandular adipose and fi-
brous tissue[2] Hamartomas were first described
in 1971 by Arrigoni et al in a study of 10 patients
which breast tumors clinically and grossly re-
sembled fibroadenomas[3]
A higher predominance of tumors exists in fe-
males compared with males Hamartomas are
slowly-growing lesions with the diameter rang-
ing from 2 cm to 5 cm sometimes hamartomas
can reach giant diameter [4]
The clinical diagnosis of hamartoma is based on
the findings from mammography sonography
and histology examinations The hamartomas are
usually incidentally diagnosed by the women
older than 40 year-old starting mammography
screening
On physicial examination harmatomas are usu-
ally occult painless they may be as large mo-
bile soft to firm masses[5] Ultrasound showed
well capsulated mass with echogenic rim and
internal heterogeneity Mammography exam
showed well-circumscribed round to oval
masses containing fat and soft tissue densities
with a thin radiopaque pseudocapsule The
pseudocapsule results from displacement of
breast parenchyma by the tumor [56] In Pa-
thology finding microglandular adenosis is pre-
sent in fibroadipose stroma surrounded by a thin
fibrous capsule It composed of a combination of
epithelial and stromal elements usually with
normal ducts or lobules although variations of
normal tissue may also be seen Fibroadenoli-
poma myoid hamartoma and chondrolipoma are
histological variations of hamartomas depend-
ing on the proportion of normal breast tissue
elements[7]
Malignancy associated with hamartomas are
very rare[8] However it has been reported
hamartomas develop into carcinoma Malignant
transformation can occur as a result of cellular
atypia in the epithelial component of the mass[9]
Surgical removal is the curative method for
breast hamartomas[10] Diagnostic material such
as mammography ultrasonography or core nee-
dle biopsy may not give the definitive diagnosis
Therefore surgical excision and histological
examination is necessary for differential diagno-
sis[111213]
Although it is rare hamartoma can be seen along
with malignancy as it is formed from similar
components of breast tissue Therefore careful
diagnosis and appropriate management including
surgery are required
REFERENCES 1 World Health Organization (1981)
Histological typing of breast tumors In
International histological classification of
tumors 1981 2nd ed
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
128
2 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11435ndash449
2006
3 ArrigoniMG DockertyMB JuddES
The identificationand treatment of
mammary hamartoma Surg Gynecol
Obstet1971 133 577-82
4 Sanal HT Ersoz N Altinel O Unal E Can
C Giant hamartoma of the breast Breast J
2006 12 84-85
5 Feder JM de Paredes ES Hogge JP
Wilken JJ Unusual breast lesions
radiologic-pathologic correlation
Radiographics 1999 19S11ndashS26
6 Murat A Ozdemir H Yildirim H Poyraz
AK Ozercan R Hamartoma of the breast
Australas Radiol 200751 Spec NoB37ndash
9
7 Fisher CJ Hanby AM Robinson L Millis
RR Mammary hamartoma-a review of 35
cases Histopathology 1992 20 99-106
8 Choi N Ko ES Invasive ductal carcinoma
in a mammary hamartoma case report and
review of the literature Korean J Radiol
2010 Nov-Dec11(6)687-91
9 Lee EH Wylie EJ Bourke AG Bastiaan
De Boer W Invasive ductal carcinoma
arising in a breast hamartoma two case
reports and a review of the literature Clin
Radiol 2003 58 80-3
10 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11 435 ‑449
2006
11 Coyne J Hobbs FM Boggis C Harland R
Lobular carcinoma in a mammary
hamartoma J Clin Pathol 199245936ndash
937
12 G M K Tse B K B Law T K F Ma A B W
Chan Hamartoma of the breast a
clinicopathological review J Clin Pathol
200255951ndash954
13 RAAmir SSheikh BreasthamartomaA
report of 14cases of an under-recognized
and under-reported entity International
Journal of Surgery Case Reports
22(2016)1ndash4
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
129
FIGURES
Figure 1 Ultrasound shows a 4411 cm hypoechoic lesion with lipoma at 3 oclock 2 cm from nipple
of right breast
Figure 2 Photomicrograph shows mammary hamartoma composed of ducts lobules with interlobular
fibrous tissue and adipose tissue
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
130
Hamartoma of the breast A case report
乳房錯構瘤罕見個案報告
陳宣安 1羅承裕 3黃世鴻 3林錦龍 2
中文摘要
乳房錯構瘤是一種罕見之乳房良性腫瘤切除手術及病理化驗來做鑑別診斷
我們報告一位 49歲女性以可觸摸到無痛性右側乳房腫塊為臨床表徵超音波
看到一個邊緣清楚低迴音的腫塊病患接受手術切除病灶病理診斷證實為乳
房錯構瘤
關鍵字乳房腫瘤錯構瘤超音波攝影
1國泰綜合醫院外科部
2國泰綜合醫院一般外科
3國泰綜合醫院病理科
通訊作者林錦龍 電子信箱 lungyungmailcom
Fu-Jen Journal of Medicine
Mission and Goals
The Fu-Jen Journal of Medicine (FJJM) is a peer-reviewed journal which
aims to enhance research quality of staffs in the College of Medicine Fu Jen
Catholic University The journal publishes original investigations across a
wide range of medical disciplines including original research articles in basic
and clinical sciences case reports review articles brief reports and letter
to the editor FJJM is now issued by the Center of Medical Education in the
College of Medicine Fu Jen Catholic University To promote journal quality
the manuscript submitted to FJJM after August first 2015 has to be prepared
in English to meet the international standards
Issue Date
Publication Date
Institution
December 01 2003
September 30 2020
College of Medicine Fu Jen Catholic University
Honorable publisher Han-Sun Chiang
Publisher Ping-Keung Yip
Editor-in-chief Ming-Chieh Ma
Associate Editors Yu-Wen Lin
Editors
Telephone (02) 2905-3477
Address Center for Medical Education College of Medicine Fu Jen
Catholic University
No 510 Zhongzheng Rd Xinzhuang Dist New Taipei City
24205 Taiwan
Su-Jane Wang Chi-Chung Wang Chih-Ming Ho
Yih-Jing Lee Chih-Shung Wong Tze-Wah Kao
Chi-Feng Hung Rung-Fen Feng Chee-Fah Chogn
Chia-Chen Lu Zai-Ting Yeh
Dee Pei Chih-Kuang Liu
Hen-Hui Lien Chien-Hsiou Liu
Chun-Hou Liao Yi-Ju Tsai Sheng-Wen Teng
Chia-Ting Su
- 9月封面
- 9月目錄頁
- 2020九月刊排版NO1_完稿
- 2020九月刊排版NO2_完稿
- 2020九月刊排版NO3_完稿
- 2020九月刊排版NO4_完稿
- 2020九月刊排版NO5_完稿
- 版權頁(SEP)
- 9月封底
-
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
127
INTRODUCTION The hamartoma is a benign tumor-like lesion
that can affect various organs of the body in-
cluding lungs kidneys skin and more rarely the
breast In 1981 the hamartomas were recognized
in the WHO classification[1] They are defined
as well-demarcated mass of mammary ducts and
lobules containing varying amounts of fibrous
and adipose tissue and producing a distinctive
mammographic image
CASE REPORT A 49 year-old female had past history of left
breast mastitis with abscess status post partial
mastectomy This time she presented to our out
patient clinic for breast examination Physical
examination revealed a painless palpable mova-
ble and painless lump at upper outer quadrant of
right breast The risk of breast cancer was not
noted and the patient did not have any family
history of breast cancer The patient also denied
any trauma history before Ultrasound examina-
tion was arranged which demonstrated a 4411
cm hypoechoic lesion with lipoma at 3 oclock 2
cm from nipple of right breast and multiple hy-
poechoic nodules of various size in both breasts
and there was no suspicious axillary lymph
nodes noted (Figure1) Surgical treatment was
arranged partial mastectomy of right breast
harmartoma was successfully performed A 32 x
31 x 21 cm tumor was completely excised
Grossly examination showed a gray to yellow
and firm to fatty The diagnosis of a hamartoma
was confirmed by the histological examination
Microscopically sections of the breast lesion
show mammary hamartoma composed of ducts
lobules with interlobular fibrous tissue and adi-
pose tissue Fibrocystic change apocrine meta-
plastic ducts and scattered foci of adenosis are
noted The overall lobulocentric architecture and
the 2-cell pattern of the epithelium are preserved
columnar cell change and focal microcalcifica-
tion are present (Figure2) Based on submitted
biopsy specimen in-situ or invasive tumor cells
are not identified
DISCUSSION Hamartoma of the breast is a benign tumor like
nodule it was also known as fibroadenolipoma
lipofibroadenoma or adenolipoma based on its
predominant components It was composed of
varying amounts of glandular adipose and fi-
brous tissue[2] Hamartomas were first described
in 1971 by Arrigoni et al in a study of 10 patients
which breast tumors clinically and grossly re-
sembled fibroadenomas[3]
A higher predominance of tumors exists in fe-
males compared with males Hamartomas are
slowly-growing lesions with the diameter rang-
ing from 2 cm to 5 cm sometimes hamartomas
can reach giant diameter [4]
The clinical diagnosis of hamartoma is based on
the findings from mammography sonography
and histology examinations The hamartomas are
usually incidentally diagnosed by the women
older than 40 year-old starting mammography
screening
On physicial examination harmatomas are usu-
ally occult painless they may be as large mo-
bile soft to firm masses[5] Ultrasound showed
well capsulated mass with echogenic rim and
internal heterogeneity Mammography exam
showed well-circumscribed round to oval
masses containing fat and soft tissue densities
with a thin radiopaque pseudocapsule The
pseudocapsule results from displacement of
breast parenchyma by the tumor [56] In Pa-
thology finding microglandular adenosis is pre-
sent in fibroadipose stroma surrounded by a thin
fibrous capsule It composed of a combination of
epithelial and stromal elements usually with
normal ducts or lobules although variations of
normal tissue may also be seen Fibroadenoli-
poma myoid hamartoma and chondrolipoma are
histological variations of hamartomas depend-
ing on the proportion of normal breast tissue
elements[7]
Malignancy associated with hamartomas are
very rare[8] However it has been reported
hamartomas develop into carcinoma Malignant
transformation can occur as a result of cellular
atypia in the epithelial component of the mass[9]
Surgical removal is the curative method for
breast hamartomas[10] Diagnostic material such
as mammography ultrasonography or core nee-
dle biopsy may not give the definitive diagnosis
Therefore surgical excision and histological
examination is necessary for differential diagno-
sis[111213]
Although it is rare hamartoma can be seen along
with malignancy as it is formed from similar
components of breast tissue Therefore careful
diagnosis and appropriate management including
surgery are required
REFERENCES 1 World Health Organization (1981)
Histological typing of breast tumors In
International histological classification of
tumors 1981 2nd ed
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
128
2 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11435ndash449
2006
3 ArrigoniMG DockertyMB JuddES
The identificationand treatment of
mammary hamartoma Surg Gynecol
Obstet1971 133 577-82
4 Sanal HT Ersoz N Altinel O Unal E Can
C Giant hamartoma of the breast Breast J
2006 12 84-85
5 Feder JM de Paredes ES Hogge JP
Wilken JJ Unusual breast lesions
radiologic-pathologic correlation
Radiographics 1999 19S11ndashS26
6 Murat A Ozdemir H Yildirim H Poyraz
AK Ozercan R Hamartoma of the breast
Australas Radiol 200751 Spec NoB37ndash
9
7 Fisher CJ Hanby AM Robinson L Millis
RR Mammary hamartoma-a review of 35
cases Histopathology 1992 20 99-106
8 Choi N Ko ES Invasive ductal carcinoma
in a mammary hamartoma case report and
review of the literature Korean J Radiol
2010 Nov-Dec11(6)687-91
9 Lee EH Wylie EJ Bourke AG Bastiaan
De Boer W Invasive ductal carcinoma
arising in a breast hamartoma two case
reports and a review of the literature Clin
Radiol 2003 58 80-3
10 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11 435 ‑449
2006
11 Coyne J Hobbs FM Boggis C Harland R
Lobular carcinoma in a mammary
hamartoma J Clin Pathol 199245936ndash
937
12 G M K Tse B K B Law T K F Ma A B W
Chan Hamartoma of the breast a
clinicopathological review J Clin Pathol
200255951ndash954
13 RAAmir SSheikh BreasthamartomaA
report of 14cases of an under-recognized
and under-reported entity International
Journal of Surgery Case Reports
22(2016)1ndash4
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
129
FIGURES
Figure 1 Ultrasound shows a 4411 cm hypoechoic lesion with lipoma at 3 oclock 2 cm from nipple
of right breast
Figure 2 Photomicrograph shows mammary hamartoma composed of ducts lobules with interlobular
fibrous tissue and adipose tissue
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
130
Hamartoma of the breast A case report
乳房錯構瘤罕見個案報告
陳宣安 1羅承裕 3黃世鴻 3林錦龍 2
中文摘要
乳房錯構瘤是一種罕見之乳房良性腫瘤切除手術及病理化驗來做鑑別診斷
我們報告一位 49歲女性以可觸摸到無痛性右側乳房腫塊為臨床表徵超音波
看到一個邊緣清楚低迴音的腫塊病患接受手術切除病灶病理診斷證實為乳
房錯構瘤
關鍵字乳房腫瘤錯構瘤超音波攝影
1國泰綜合醫院外科部
2國泰綜合醫院一般外科
3國泰綜合醫院病理科
通訊作者林錦龍 電子信箱 lungyungmailcom
Fu-Jen Journal of Medicine
Mission and Goals
The Fu-Jen Journal of Medicine (FJJM) is a peer-reviewed journal which
aims to enhance research quality of staffs in the College of Medicine Fu Jen
Catholic University The journal publishes original investigations across a
wide range of medical disciplines including original research articles in basic
and clinical sciences case reports review articles brief reports and letter
to the editor FJJM is now issued by the Center of Medical Education in the
College of Medicine Fu Jen Catholic University To promote journal quality
the manuscript submitted to FJJM after August first 2015 has to be prepared
in English to meet the international standards
Issue Date
Publication Date
Institution
December 01 2003
September 30 2020
College of Medicine Fu Jen Catholic University
Honorable publisher Han-Sun Chiang
Publisher Ping-Keung Yip
Editor-in-chief Ming-Chieh Ma
Associate Editors Yu-Wen Lin
Editors
Telephone (02) 2905-3477
Address Center for Medical Education College of Medicine Fu Jen
Catholic University
No 510 Zhongzheng Rd Xinzhuang Dist New Taipei City
24205 Taiwan
Su-Jane Wang Chi-Chung Wang Chih-Ming Ho
Yih-Jing Lee Chih-Shung Wong Tze-Wah Kao
Chi-Feng Hung Rung-Fen Feng Chee-Fah Chogn
Chia-Chen Lu Zai-Ting Yeh
Dee Pei Chih-Kuang Liu
Hen-Hui Lien Chien-Hsiou Liu
Chun-Hou Liao Yi-Ju Tsai Sheng-Wen Teng
Chia-Ting Su
- 9月封面
- 9月目錄頁
- 2020九月刊排版NO1_完稿
- 2020九月刊排版NO2_完稿
- 2020九月刊排版NO3_完稿
- 2020九月刊排版NO4_完稿
- 2020九月刊排版NO5_完稿
- 版權頁(SEP)
- 9月封底
-
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
128
2 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11435ndash449
2006
3 ArrigoniMG DockertyMB JuddES
The identificationand treatment of
mammary hamartoma Surg Gynecol
Obstet1971 133 577-82
4 Sanal HT Ersoz N Altinel O Unal E Can
C Giant hamartoma of the breast Breast J
2006 12 84-85
5 Feder JM de Paredes ES Hogge JP
Wilken JJ Unusual breast lesions
radiologic-pathologic correlation
Radiographics 1999 19S11ndashS26
6 Murat A Ozdemir H Yildirim H Poyraz
AK Ozercan R Hamartoma of the breast
Australas Radiol 200751 Spec NoB37ndash
9
7 Fisher CJ Hanby AM Robinson L Millis
RR Mammary hamartoma-a review of 35
cases Histopathology 1992 20 99-106
8 Choi N Ko ES Invasive ductal carcinoma
in a mammary hamartoma case report and
review of the literature Korean J Radiol
2010 Nov-Dec11(6)687-91
9 Lee EH Wylie EJ Bourke AG Bastiaan
De Boer W Invasive ductal carcinoma
arising in a breast hamartoma two case
reports and a review of the literature Clin
Radiol 2003 58 80-3
10 Guray M and Sahin AA Benign breast
diseases classification diagnosis and
management Oncologist 11 435 ‑449
2006
11 Coyne J Hobbs FM Boggis C Harland R
Lobular carcinoma in a mammary
hamartoma J Clin Pathol 199245936ndash
937
12 G M K Tse B K B Law T K F Ma A B W
Chan Hamartoma of the breast a
clinicopathological review J Clin Pathol
200255951ndash954
13 RAAmir SSheikh BreasthamartomaA
report of 14cases of an under-recognized
and under-reported entity International
Journal of Surgery Case Reports
22(2016)1ndash4
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
129
FIGURES
Figure 1 Ultrasound shows a 4411 cm hypoechoic lesion with lipoma at 3 oclock 2 cm from nipple
of right breast
Figure 2 Photomicrograph shows mammary hamartoma composed of ducts lobules with interlobular
fibrous tissue and adipose tissue
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
130
Hamartoma of the breast A case report
乳房錯構瘤罕見個案報告
陳宣安 1羅承裕 3黃世鴻 3林錦龍 2
中文摘要
乳房錯構瘤是一種罕見之乳房良性腫瘤切除手術及病理化驗來做鑑別診斷
我們報告一位 49歲女性以可觸摸到無痛性右側乳房腫塊為臨床表徵超音波
看到一個邊緣清楚低迴音的腫塊病患接受手術切除病灶病理診斷證實為乳
房錯構瘤
關鍵字乳房腫瘤錯構瘤超音波攝影
1國泰綜合醫院外科部
2國泰綜合醫院一般外科
3國泰綜合醫院病理科
通訊作者林錦龍 電子信箱 lungyungmailcom
Fu-Jen Journal of Medicine
Mission and Goals
The Fu-Jen Journal of Medicine (FJJM) is a peer-reviewed journal which
aims to enhance research quality of staffs in the College of Medicine Fu Jen
Catholic University The journal publishes original investigations across a
wide range of medical disciplines including original research articles in basic
and clinical sciences case reports review articles brief reports and letter
to the editor FJJM is now issued by the Center of Medical Education in the
College of Medicine Fu Jen Catholic University To promote journal quality
the manuscript submitted to FJJM after August first 2015 has to be prepared
in English to meet the international standards
Issue Date
Publication Date
Institution
December 01 2003
September 30 2020
College of Medicine Fu Jen Catholic University
Honorable publisher Han-Sun Chiang
Publisher Ping-Keung Yip
Editor-in-chief Ming-Chieh Ma
Associate Editors Yu-Wen Lin
Editors
Telephone (02) 2905-3477
Address Center for Medical Education College of Medicine Fu Jen
Catholic University
No 510 Zhongzheng Rd Xinzhuang Dist New Taipei City
24205 Taiwan
Su-Jane Wang Chi-Chung Wang Chih-Ming Ho
Yih-Jing Lee Chih-Shung Wong Tze-Wah Kao
Chi-Feng Hung Rung-Fen Feng Chee-Fah Chogn
Chia-Chen Lu Zai-Ting Yeh
Dee Pei Chih-Kuang Liu
Hen-Hui Lien Chien-Hsiou Liu
Chun-Hou Liao Yi-Ju Tsai Sheng-Wen Teng
Chia-Ting Su
- 9月封面
- 9月目錄頁
- 2020九月刊排版NO1_完稿
- 2020九月刊排版NO2_完稿
- 2020九月刊排版NO3_完稿
- 2020九月刊排版NO4_完稿
- 2020九月刊排版NO5_完稿
- 版權頁(SEP)
- 9月封底
-
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
129
FIGURES
Figure 1 Ultrasound shows a 4411 cm hypoechoic lesion with lipoma at 3 oclock 2 cm from nipple
of right breast
Figure 2 Photomicrograph shows mammary hamartoma composed of ducts lobules with interlobular
fibrous tissue and adipose tissue
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
130
Hamartoma of the breast A case report
乳房錯構瘤罕見個案報告
陳宣安 1羅承裕 3黃世鴻 3林錦龍 2
中文摘要
乳房錯構瘤是一種罕見之乳房良性腫瘤切除手術及病理化驗來做鑑別診斷
我們報告一位 49歲女性以可觸摸到無痛性右側乳房腫塊為臨床表徵超音波
看到一個邊緣清楚低迴音的腫塊病患接受手術切除病灶病理診斷證實為乳
房錯構瘤
關鍵字乳房腫瘤錯構瘤超音波攝影
1國泰綜合醫院外科部
2國泰綜合醫院一般外科
3國泰綜合醫院病理科
通訊作者林錦龍 電子信箱 lungyungmailcom
Fu-Jen Journal of Medicine
Mission and Goals
The Fu-Jen Journal of Medicine (FJJM) is a peer-reviewed journal which
aims to enhance research quality of staffs in the College of Medicine Fu Jen
Catholic University The journal publishes original investigations across a
wide range of medical disciplines including original research articles in basic
and clinical sciences case reports review articles brief reports and letter
to the editor FJJM is now issued by the Center of Medical Education in the
College of Medicine Fu Jen Catholic University To promote journal quality
the manuscript submitted to FJJM after August first 2015 has to be prepared
in English to meet the international standards
Issue Date
Publication Date
Institution
December 01 2003
September 30 2020
College of Medicine Fu Jen Catholic University
Honorable publisher Han-Sun Chiang
Publisher Ping-Keung Yip
Editor-in-chief Ming-Chieh Ma
Associate Editors Yu-Wen Lin
Editors
Telephone (02) 2905-3477
Address Center for Medical Education College of Medicine Fu Jen
Catholic University
No 510 Zhongzheng Rd Xinzhuang Dist New Taipei City
24205 Taiwan
Su-Jane Wang Chi-Chung Wang Chih-Ming Ho
Yih-Jing Lee Chih-Shung Wong Tze-Wah Kao
Chi-Feng Hung Rung-Fen Feng Chee-Fah Chogn
Chia-Chen Lu Zai-Ting Yeh
Dee Pei Chih-Kuang Liu
Hen-Hui Lien Chien-Hsiou Liu
Chun-Hou Liao Yi-Ju Tsai Sheng-Wen Teng
Chia-Ting Su
- 9月封面
- 9月目錄頁
- 2020九月刊排版NO1_完稿
- 2020九月刊排版NO2_完稿
- 2020九月刊排版NO3_完稿
- 2020九月刊排版NO4_完稿
- 2020九月刊排版NO5_完稿
- 版權頁(SEP)
- 9月封底
-
Fu-Jen Journal of Medicine Vol 3 No 5 2020
Acute intramembranous hemorrhage
Hsuan-An Chen Cheng-Yu Lo Shih-Hung Huang Chin-Lung Lin
130
Hamartoma of the breast A case report
乳房錯構瘤罕見個案報告
陳宣安 1羅承裕 3黃世鴻 3林錦龍 2
中文摘要
乳房錯構瘤是一種罕見之乳房良性腫瘤切除手術及病理化驗來做鑑別診斷
我們報告一位 49歲女性以可觸摸到無痛性右側乳房腫塊為臨床表徵超音波
看到一個邊緣清楚低迴音的腫塊病患接受手術切除病灶病理診斷證實為乳
房錯構瘤
關鍵字乳房腫瘤錯構瘤超音波攝影
1國泰綜合醫院外科部
2國泰綜合醫院一般外科
3國泰綜合醫院病理科
通訊作者林錦龍 電子信箱 lungyungmailcom
Fu-Jen Journal of Medicine
Mission and Goals
The Fu-Jen Journal of Medicine (FJJM) is a peer-reviewed journal which
aims to enhance research quality of staffs in the College of Medicine Fu Jen
Catholic University The journal publishes original investigations across a
wide range of medical disciplines including original research articles in basic
and clinical sciences case reports review articles brief reports and letter
to the editor FJJM is now issued by the Center of Medical Education in the
College of Medicine Fu Jen Catholic University To promote journal quality
the manuscript submitted to FJJM after August first 2015 has to be prepared
in English to meet the international standards
Issue Date
Publication Date
Institution
December 01 2003
September 30 2020
College of Medicine Fu Jen Catholic University
Honorable publisher Han-Sun Chiang
Publisher Ping-Keung Yip
Editor-in-chief Ming-Chieh Ma
Associate Editors Yu-Wen Lin
Editors
Telephone (02) 2905-3477
Address Center for Medical Education College of Medicine Fu Jen
Catholic University
No 510 Zhongzheng Rd Xinzhuang Dist New Taipei City
24205 Taiwan
Su-Jane Wang Chi-Chung Wang Chih-Ming Ho
Yih-Jing Lee Chih-Shung Wong Tze-Wah Kao
Chi-Feng Hung Rung-Fen Feng Chee-Fah Chogn
Chia-Chen Lu Zai-Ting Yeh
Dee Pei Chih-Kuang Liu
Hen-Hui Lien Chien-Hsiou Liu
Chun-Hou Liao Yi-Ju Tsai Sheng-Wen Teng
Chia-Ting Su
- 9月封面
- 9月目錄頁
- 2020九月刊排版NO1_完稿
- 2020九月刊排版NO2_完稿
- 2020九月刊排版NO3_完稿
- 2020九月刊排版NO4_完稿
- 2020九月刊排版NO5_完稿
- 版權頁(SEP)
- 9月封底
-
Fu-Jen Journal of Medicine
Mission and Goals
The Fu-Jen Journal of Medicine (FJJM) is a peer-reviewed journal which
aims to enhance research quality of staffs in the College of Medicine Fu Jen
Catholic University The journal publishes original investigations across a
wide range of medical disciplines including original research articles in basic
and clinical sciences case reports review articles brief reports and letter
to the editor FJJM is now issued by the Center of Medical Education in the
College of Medicine Fu Jen Catholic University To promote journal quality
the manuscript submitted to FJJM after August first 2015 has to be prepared
in English to meet the international standards
Issue Date
Publication Date
Institution
December 01 2003
September 30 2020
College of Medicine Fu Jen Catholic University
Honorable publisher Han-Sun Chiang
Publisher Ping-Keung Yip
Editor-in-chief Ming-Chieh Ma
Associate Editors Yu-Wen Lin
Editors
Telephone (02) 2905-3477
Address Center for Medical Education College of Medicine Fu Jen
Catholic University
No 510 Zhongzheng Rd Xinzhuang Dist New Taipei City
24205 Taiwan
Su-Jane Wang Chi-Chung Wang Chih-Ming Ho
Yih-Jing Lee Chih-Shung Wong Tze-Wah Kao
Chi-Feng Hung Rung-Fen Feng Chee-Fah Chogn
Chia-Chen Lu Zai-Ting Yeh
Dee Pei Chih-Kuang Liu
Hen-Hui Lien Chien-Hsiou Liu
Chun-Hou Liao Yi-Ju Tsai Sheng-Wen Teng
Chia-Ting Su
- 9月封面
- 9月目錄頁
- 2020九月刊排版NO1_完稿
- 2020九月刊排版NO2_完稿
- 2020九月刊排版NO3_完稿
- 2020九月刊排版NO4_完稿
- 2020九月刊排版NO5_完稿
- 版權頁(SEP)
- 9月封底
-
- 9月封面
- 9月目錄頁
- 2020九月刊排版NO1_完稿
- 2020九月刊排版NO2_完稿
- 2020九月刊排版NO3_完稿
- 2020九月刊排版NO4_完稿
- 2020九月刊排版NO5_完稿
- 版權頁(SEP)
- 9月封底
-