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VOL. 16, NO. 15, MAY 1, 1987

V o l . 16, N o . 15, May 1, 1987

NOTICES

? HUMAN LIVER TISSUE FOR RESEARCH AVAILABLE .................................... 1 Nat iona l I n s t i t u t e of Diabe tes and Diges t ive and Kidney Diseases Index: AVAILABLE RESOURCES

CHANGE I N ELIGIBILITY CRITERIA FOR ADAMHA FIRST PROGR A M . . . . . . . . . . . . . . . . . . . . . . 1 Alcohol, Drug Abuse, and Mental Heal th Adminis t ra t ion Index: ALCOHOL, DRUG ABUSE, AND MENTAL HEALTH

DATED ANNOUNCEMENTS (RFPs and RFAs AVAILABLE)

PHASE I CLINICAL TRIALS OF BIOLOGICAL RESPONSE MODIFIERS (RFP)... ............2 Nat iona l Cancer I n s t i t u t e Index : CANCER

A PAPILLOMAVIRUS ANIMAL MODEL FOR EVALUATION OF EXPERIMENTAL THERAPIES ( R F P ) . . . . . ....................................... 3

Nat iona l I n s t i t u t e of A l l e rgy and I n f e c t i o u s Diseases Index: ALLERGY AND INFECTIOUS DISEASES

DEVELOPMENT OF PROTEIN-POLYSACCHARIDE PNEUMOCOCCAL. CONJUGATE VACCINES (RFP) ................................................ 3

Nat iona l I n s t i t u t e o f A l l e rgy and I n f e c t i o u s Diseases Index: ALLERGY AND INFECTIOUS DISEASES

MASTER AGREEMENT FOR THE CLINICAL EVALUATION OF INVESTIGATIONAL ANTIEPILEPTIC DRUGS (RFP) ............................... 4

Nat iona l I n s t i t u t e o f Neurological and Communicative Disorders and S t roke Index: NEUROLOGICAL AND COMMUNICATIVE DISORDERS AND STROKE

I

GENETIC BASIS OF REPRODUCTIVE DISORDERS (RFA) ................................ 5 Nat iona l I n s t i t u t e o f Chi ld Heal th and Human Development

;i Index: CHILD HEALTH AND HUMAN DEVELOPMENT c i;wv CENTERS FOR INTERDISCIPLINARY RESEARCH ON IMMUNOLOGIC DISEASES (RFA) .........6 i Nat iona l I n s t i t u t e of A l l e r g y and I n f e c t i o u s Diseasesi Index: ALLERGY AND INFECTIOUS DISEASES

1 ASTHMA AND ALLERGIC DISEASES CENTERS (RFA) ................................... 7 Nat iona l I n s t i t u t e o f A l l e r g y and I n f e c t i o u s Diseases

I . Index: ALLERGY AND INFECTIOUS DISEASES

CORE GRANTS FOR CLINICAL NUTRITION RESEARCH UNITS ( C N R U s ) (RFA).. ............8 Nat iona l I n s t i t u t e of Diabe tes and Diges t ive and Kidney Diseases National I n s t i t u t e on Aging

\Index : DIABETES AND DIGESTIVE AND KIDNEY DISEASES AGING

MINORITY MENTAL HEALTH RESEARCH CENTERS ...................................... 9 Nat iona l I n s t i t u t e of Mental Heal th Index: MENTAL HEALTH

ADDENDUM

RESEARCH GRANTS RELATED TO PAIN AND ANALGESIA ................................ 10 Alcohol, Drug Abuse, and Mental Heal th Adminis t ra t ion Index: ALCOHOL, DRUG ABUSE, AND MENTAL HEALTH

ERRATUM

SOCIAL AND DEMOGRAPHIC RESEARCH ON INFANT MORTALITY AND LOW BIRTHWEIGHT ............................................................. 10

Plrr’ Nat iona l I n s t i t u t e o f Child Health and Human DevelopmentIndex: CHILD HEALTH AND HUMAN DEVELOPMENT

NOTICES

HUMAN LIVER TISSUE FOR RESEARCH AVAILABLE

P.T. 34; K.W. 0780005

Nat iona l I n s t i t u t e of Diabe tes and Diges t ive and Kidney Diseases

Human l i v e r f o r sc ien t i f ic i n v e s t i g a t i o n is a v a i l a b l e through t h e Nat iona l I n s t t u ;eo f Diabe tes and Diges t ive and Kidney Diseases, N I H suppor ted L ive r T i s sue Procurement and D i s t r i b u t i o n System (LTPADS). F ive r e g i o n a l c e n t e r s have been subcon t rac t ed f o r t h e c o l l e c t i o n o f l i v e r s ob ta ined a t t h e t i m e o f t r a n s p l a n t f o r s c i e n t i f i c i n v e s t i g a t o r s nationwide. Fu r the r in format ion and proposa l forms f o r i n t e r e s t e d i n v e s t i g a t o r s can be obta ined from:

Harvey L . Sharp. M.D. LTPADS Box 279 Mayo Bui ld ing Unive r s i ty o f Minnesota Hosp i t a l Minneapolis, MN 55455 Telephone: (612) 624-1133 o r 624-2422

CHANGE I N ELIGIBILITY CRITERIA FOR ADAMHA FIRST PROGRAM

P.T. 34; K.W. 0710030, 0404000, 0785035, 1014002

Alcohol, Drug Abuse, and Mental Health Adminis t ra t ion

This n o t i c e is t o announce t h a t r e c i p i e n t s o f Research S c i e n t i s t Development, Level I (KOl), Academic I n v e s t i g a t o r (K071, C l i n i c a l I n v e s t i g a t o r (KO81 and Phys ic ian S c i e n t i s t Awards ( K 1 1 ) may apply f o r and r e c e i v e FIRST awards from ADAMHA p rov id ing t h e y meet o t h e r e l i g i b i l i t y c r i t e r i a f o r FIRST awards. The purpose o f t h i s e l i g i b i l i t y change is t o recognize t h a t t h e K awardees are t y p i c a l l y among t h e most promising developing s c i e n t i s t s and t h e r e f o r e it is a p p r o p r i a t e t o a f f o r d them t h e oppor tun i ty , when t h e y are ready f o r independent i n v e s t i g a t i o n , t o r e c e i v e an award

’---., which p rov ides a s p e c i a l suppor t mechanism f o r new i n v e s t i g a t o r s .v The FIRST award is in tended t o provide newly independent i n v e s t i g a t o r s wi th a -Wp s u f f i c i e n t pe r iod of i n i t i a l r e sea rch suppor t t o demonstrate t h e i r r e s e a r c h

c r e a t i v i t y , p r o d u c t i v i t y and f u t u r e promise. It is a r e s e a r c h p r o j e c t award which must r e p r e s e n t a t l eas t 50 percent e f f o r t o f t h e i n v e s t i g a t o r . The v a r i o u s K awards mentioned above have as t h e i r goa l suppor t ing t h e development of s c i e n t i s t s i n t o independent i n v e s t i g a t o r s , i nc lud ing a pe r iod of supe rv i sed r e s e a r c h .

K01, K07, KO8 and K11 r e c i p i e n t s who apply f o r FIRST awards w i l l be judged, as are o t h e r FIRST a p p l i c a n t s , on t h e b a s i s of whether t hey are ready f o r independenti n v e s t i g a t i o n . Accordingly, it would n o t be pe rmis s ib l e f o r an i n d i v i d u a l t o s imul taneous ly submit an a p p l i c a t i o n f o r both a K and a FIRST a p p l i c a t i o n . Rather , an i n d i v i d u a l who i s a r e c i p i e n t of a K award must have he ld t h a t award f o r a s u f f i c i e n t period of t i m e t o be able t o demonstrate readiness t o undertake an independent r e s e a r c h p r o j e c t . Other c o n d i t i o n s of both t h e FIRST and K awards will apply . Once an i n v e s t i g a t o r r e c e i v e s a FIRST award, he o r she w i l l n o t be able t o r e c e i v e a r e s e a r c h allowance under t h e K award.

This change i n e l i g i b i l i t y c r i t e r i a f o r t h e FIRST program w i l l be e f f e c t i v e f o r a p p l i c a t i o n s submi t ted beginning wi th t h e June 1 , 1987 r e c e i p t d a t e .

For cop ie s of announcements f o r t h e K programs mentioned i n t h i s n o t i c e o r t h e FIRST program, c o n t a c t t h e fo l lowing:

Anne CooleyNat iona l I n s t i t u t e of Mental Health Extramural Po l i cy Branch, DEA 5600 F i s h e r s Lane, Room 9-95 Rockvi l le , Maryland 20857 Telephone: ( 3 0 1 ) 443-4673

Nat iona l Clearinghouse on Alcohol Informat ion 1776 P laza E . J e f f e r s o n S t r e e t Rockvi l le , Maryland 20852

\ Telephone: ( 3 0 1 ) 468-2600 -#

1

Nat iona l I n s t i t u t e on Drug Abuse Grants Management Branch 5600 F i s h e r s Lane Room 10-25 Rockvi l le , Maryland 20857 Telephone: ( 3 0 1 ) 443-6710

DATED ANNOUNCEMENTS (RFPs and RFAs AVAILABLE)

PHASE I CLINICAL TRIALS OF BIOLOGICAL RESPONSE MODIFIERS

RFP AVAILABLE: NCI-CM-87215-18

P.T. 34; K.W. 0740015, 0755015, 0760045, 0710100

Nat iona l Cancer I n s t i t u t e

The B i o l o g i c a l Response Modif iers Program (BRMP) o f t h e Div is ion o f Cancer Treatment (DCT), Nat iona l Cancer I n s t i t u t e , is seeking o r g a n i z a t i o n s t o perform Phase I c l i n i c a l t r i a l s o f b i o l o g i c a l response modi f ie rs (BRMs) , and, i n a d d i t i o n , t o have t h e c a p a b i l i t y t o perform b a s i c immunologic, pharmacokinetic and c l i n i c a l monitor ing as r e q u i r e d by t h e fo l lowing t a s k s .

Task A: Phase I C l i n i c a l S t u d i e s o f Monoclonal Antibodies o r Monoclonal Immunoconjugates i n Cancer.

T h i s t h e o r e t i c a l p r o t o c o l s h a l l be a Phase I I B c l i n i c a l and l a b o r a t o r y e v a l u a t i o n o f an a c t u a l unconjugated monoclonal an t ibody. The t h e o r e t i c a l p r o t o c o l should address , b u t is n o t l i m i t e d t o , t h e fo l lowing:

Objec t ives :

1.1 To determine t h e opt imal b i o l o g i c a l dose o f ( i n v e s t i g a t i o n a l agent XI 1 . 2 To determine t h e t o x i c i t i e s o f ( i n v e s t i g a t i o n a l agent x )1 .3 To determine t h e effects o f ( i n v e s t i g a t i o n a l agent x ) on tumor response.

Task B: Phase I C l i n i c a l S t u d i e s o f Cytokines and Immunomodulators Alone or i n Combination wi th Other Anti-Cancer Modal i t ies i n Cancer P a t i e n t s .

T h i s t h e o r e t i c a l p r o t o c o l s h a l l be a Phase I B c l i n i c a l and l a b o r a t o r y e v a l u a t i o n o f an a c t u a l Cytokine o f Immunomodulator o t h e r t h a n an I n t e r f e r o n o f I n t e r l e u k i n - 2 .

The t h e o r e t i c a l p r o t o c o l should address , bu t is n o t l i m i t e d t o , t h e fol lowing:

Objec t ives :

1.1 To determine t h e opt imal b i o l o g i c a l dose o f ( i n v e s t i g a t i o n a l agent XI. 1 . 2 To determine t h e t o x i c i t i e s o f ( i n v e s t i g a t i o n a l agent x ) .1 . 3 To determine t h e effect o f ( i n v e s t i g a t i o n a l agent x ) on tumor response.

Approximately 8 awards w i l l be made for t h i s s t u d y . It is a n t i c i p a t e d t h a t cost-reimbursement, 5 year incrementally-funded c o n t r a c t s w i l l be awarded as a r e s u l t o f t h e RFP.

A preproposa l conference is planned f o r p r o s p e c t i v e o f f e r o r s f o r t h e purpose of provid ing informat ion which may be h e l p f u l i n t h e p r e p a r a t i o n o f proposa ls and t o answer any q u e s t i o n s which o f f e r o r s may have regard ing t h i s s o l i c i t a t i o n . Completei n s t r u c t i o n s w i l l be provided i n t h e RFP package.

T h i s synops is i s n o t a r e q u e s t f o r proposa l . The RFP f o r t h e above d e s c r i b e d work w i l l be a v a i l a b l e t o i n t e r e s t e d o f f e r o r s on o r about May 5 , 1987.

A l l r e s p o n s i b l e sources may submit a proposa l which s h a l l be considered by t h e agency.

Requests f o r t h e s o l i c i t a t i o n must r e f e r e n c e RFP NCI-CM-87215-18 and should be addressed t o :

Cather ine V. Baker Contrac t S p e c i a l i s t Nat iona l Cancer I n s t i t u t e Research C o n t r a c t s Branch, TCS B l a i r Bui ld ing , Room 212 Bethesda, Maryland 20892 Telephone : ( 3 0 1 1 427-8737

2

A PAPILLOMAVIRUS ANIMAL MODEL FOR EVALUATION OF EXPERIMENTAL THERAPIES

RFP AVAILABLE: NIH-NIAID-MIDP-88-2

P.T. 34; K.W. 1002045, 0715125

Nat iona l I n s t i t u t e o f Allergy and I n f e c t i o u s Liseases

The Development and Appl ica t ion Branch o f t h e Microbiology and I n f e c t i o u s Disease Program, Nat ional I n s t i t u t e of Al le rgy and I n f e c t i o u s Diseases , is s o l i c i t i n g proposa ls from o r g a n i z a t i o n s having t h e c a p a b i l i t i e s and f a c i l i t i e s t o employ an a p p r o p r i a t e papi l lomavi rus animal model system t o s c r e e n t h e e f f i c a c y of a n t i v i r a l subs tances and provide badly-needed b a s i s information on t h e n a t u r a l h i s t o r y and pathogenes is o f papilloma v i r u s i n f e c t i o n s .

Current t rea tment f o r papi l lomavirus i n f e c t i o n is l i m i t e d t o t o p i c a l t h e r a p i e s which d e s t r o y t i s s u e , are l i m i t e d t o v i s i b l e l e s i o n s , and are a s s o c i a t e d wi th unacceptably high recur rence rates. Consequently, t h e r e is a clear need t o i d e n t i f y e f f e c t i v e sys temic chemotherapeutic a g e n t s . The a v a i l a b i l i t y o f animal model systems mimickinghuman papi l lomavi rus i n f e c t i o n , as w e l l as t h e r e c e n t l y achieved increased molecular understanding o f t h e v i r u s , make it f e a s i b l e t o i n i t i a t e a program t o i d e n t i f y t h e r a p e u t i c a g e n t s f o r t h e s e i n f e c t i o n s .

T h i s i s an announcement of a new s o l i c i t a t i o n f o r an a n t i c i p a t e d Request f o r Proposal (RFP). RFP-NIH-NIAID-MIDP-88-2 has been a v a i l - a b l e s i n c e March 24, 1987, and proposa ls w i l l be due by c l o s e o f b u s i n e s s on J u l y 6 , 1987. One ( 1 ) award is a n t i c i p a t e d al though t h e Government r e s e r v e s t h e r i g h t t o make more t h a n one award f o r a c o n t r a c t per iod o f approximately f i v e ( 5 ) y e a r s . Requests f o r t h e RFP should be d i r e c t e d t o :

Thomas C . P o r t e r Contrac t Management Branch Nat iona l I n s t i t u t e of Allergy and I n f e c t i o u s Diseases Westwood Building, Room 707 Bethesda, Maryland 20892

Your r e q u e s t should r e f e r e n c e RFP-NIH-NIAID-88-2. P lease provide t h i s o f f i c e wi th two se l f -addressed mai l ing l a b e l s . Telephone i n q u i r i e s w i l l n o t be honored and a l l i n q u i r i e s must be i n w r i t i n g and addressed t o t h e above s t a t e d o f f i c e .

T h i s advert isement does n o t commit t h e Government t o make an award.

DEVELOPMENT OF PROTEIN-POLYSACCHARIDE PNEUMOCOCCAL CONJUGATE VACCINES

RFP AVAILABLE: NIH-NIAID-MIDP-88-5

P.T. 34; K.W. 0740075, 0745045

Nat iona l I n s t i t u t e of A l l e r g y and I n f e c t i o u s Diseases

The Development and Appl ica t ion Branch of t h e Microbiology and I n f e c t i o u s Disease Program of t h e Nat ional I n s t i t u t e o f Al le rgy and I n f e c t i o u s Diseases is s o l i c i t i n g proposa ls from o r g a n i z a t i o n s having t h e c a p a b i l i t i e s and f a c i l i t i e s t o : ( 1 ) i s o l a t e and p u r i f y c a p s u l a r polysaccharide a n t i g e n s from s e l e c t e d pneumococcal s e r o t y p e s ; (2) develop modified pneumococcal c a p s u l a r a n t i g e n s , u s i n g conjugat ion procedures , which can induce an t i -S t rep tococcus pneumoniae c a p s u l a r po lysacchar ide a n t i b o d i e s i n i n f a n t s ; (3) perform animal t e s t i n g f o r t h e vacc ines s a f e t y and potency; and (4) provide s u f f i c i e n t doses of vaccine f o r human s a f e t y , immunogenicity, and e f f i c a c y t e s t i n g . T h i s is an announcement f o r an a n t i c i p a t e d Request f o r Proposal (RFP).RFP-NIH-NIAID-MIDP-88-5 w i l l be i ssued on or about May 1, 1987, and proposa ls w i l l be due by c l o s e of b u s i n e s s June 30, 1987. One ( 1 ) award is a n t i c i p a t e d f o r a c o n t r a c t p e r i o d o f approximately t h r e e (3) y e a r s . Requests f o r t h e RFP should be d i r e c t e d t o :

Thomas C . P o r t e r Contrac t Management Branch Nat iona l I n s t i t u t e of Allergy and I n f e c t i o u s Diseases

, 1 Nat iona l I n s t i t u t e s o f Health Westwood Building, Room 707- *sw Bethesda, Maryland 20892

3

Your r e q u e s t should r e f e r e n c e NIH-NIAID-MIDP-88-5. P l e a s e provide t h i s o f f i c e wi th two se l f - addres sed mai l ing l a b e l s . Telephone i n q u i r i e s w i l l no t be honored and a l l i n q u i r i e s must be i n w r i t i n g and addressed t o t h e o f f i c e l i s t e d above. rp

T h i s adver t i sement does no t commit t h e Government t o make an award. e MASTER AGREEMENT FOR THE C L I N I C A L EVALUATION OF INVESTIGATIONAL ANTIEPILEPTIC DRUGS

MASTER AGREEMENT A"OUNCEMENT/RFP AVAILABLE: MAA-RFP-NIH-NINCDS-87-10 P.T. 3 4 ; K.W. 0715060, 0740020 , 0710100

Nat iona l I n s t i t u t e o f Neurological and Communicative Disorders and S t roke

The Ep i l epsy Branch (EB) o f t h e Convulsive, Developmental, and Neuromuscular D i so rde r s Program (CDNDP) , NINCDS p l a n s t o r e i s s u e Master Agreement Announcement (MAA)/RFP e n t i t l e d "Master Agreement f o r t h e C l i n i c a l Evalua t ion o f I n v e s t i g a t i o n a lA n t i e p i l e p t i c Drugs" wi th t h e i n t e n t of seeking new sources and e n l a r g i n g t h e poolo f c u r r e n t Master Agreement ho lde r s who a r e capable o f performing c l i n i c a l e v a l u a t i o n s o f i n v e s t i g a t i o n a l a n t i e p i l e p t i c drugs . Current Master Agreement (MA)h o l d e r s under t h i s program are no t r e q u i r e d t o respond t o t h i s RFP, u n l e s s t h e y want t o be cons idered f o r a p a r t i c u l a r s tudy ca t egory f o r which t h e y are no t c u r r e n t l yq u a l i f i e d . The a n t i e p i l e p t i c drugs t o be c l i n i c a l l y eva lua ted w i l l have been s e l e c t e d from t h e E B ' s A n t i e p i l e p t i c Drug Development (ADD) Program. Under t h i s program, an MA ho lde r w i l l be q u a l i f i e d t o compete f o r f u t u r e t a s k s , i . e . , t h e c l i n i c a l e v a l u a t i o n o f drugs i n accordance wi th s p e c i f i c p r o t o c o l s as de f ined w i t h i n t h e fo l lowing s tudy c a t e g o r i e s :

Category 1 : I n normal male v o l u n t e e r s : ( a ) an i n d i c a t i o n o f t o l e r a n c e , s a fe tyand s i d e effects and ( b ) e s t i m a t e s o f pharmacokinetic parameters fo l lowinga d m i n i s t r a t i o n o f s i n g l e o r m u l t i p l e doses o f t h e i n v e s t i g a t i o n a l drug .

Category 2: I n p a t i e n t s w i th uncon t ro l l ed s e i z u r e s : (a) an i n d i c a t i o n o f t o l e r a n c e , s a f e t y and s i d e effects and ( b ) an e s t i m a t i o n of p o s s i b l e d rug 'i n t e r a c t i o n s and pharmacokinetic parameters .

Category 3: I n p a t i e n t s wi th uncon t ro l l ed s e i z u r e s : eva lua t ion o f t h e e f f i c a c yand s a f e t y of t h e i n v e s t i g a t i o n a l drug i n c o n t r o l l e d c l i n i c a l t r i a l s .

An MA is an agreement i s sued t o sou rces who respond t o MAAIRFPs and who are judged t o be q u a l i f i e d t o compete f o r f u t u r e t a s k s i s s u e d under t h e gene ra l s tudy areas desc r ibed i n t h e MA. These agreements c o n t a i n gene ra l terms, c o n d i t i o n s and parameters o f performance f o r a p a r t i c u l a r s tudy ca tegory f o r which t h e o r g a n i z a t i o nis deemed q u a l i f i e d , bu t do n o t c o n t a i n any s p e c i f i c work t a s k , pe r iod of performance f o r a s p e c i f i c work t a s k , nor funding commitment. Award of an MA under t h i s RFP w i l l c e r t i f y an o f f e r o r as having demonstrated t h a t t hey have t h e f a c i l i t i e s , staff e x p e r t i s e , and access t o adequate s tudy popu la t ions necessa ry to perform and compete f o r f u t u r e drug e v a l u a t i o n s t u d i e s wi th in one o r more of t h e c a t e g o r i e s i n d i c a t e d above. Competition f o r s p e c i f i c c l i n i c a l i n v e s t i g a t i o n a ls t u d i e s w i l l be r e s t r i c t e d t o a l l q u a l i f i e d MA h o l d e r s . Successfu l MA compe t i to r sf o r f u t u r e s t a s k s w i l l be awarded MA Orders ( M A O ) .

An MA0 is a b i l a t e r a l c o n t r a c t and o p e r a t i o n a l addendum t o an MA. It inc ludes a d e f i n i t i z e d Statement of Work and o u t l i n e s t h e s p e c i f i c performance requi rements ,d e l i v e r y schedule and funding f o r t h e s tudy t a s k

Award of MAS under t h i s RFP w i l l be v a l i d through September 3 0 , 1991. Once awarded an MA, h o l d e r s w i l l be r e q u i r e d on an annual b a s i s t o a s s u r e t h a t t h e t h e c a p a b i l i t i e s o f t h e o r g a n i z a t i o n t h a t l e d t o i s suance o f an MA i n i t i a l l y are st i l l v a l i d and remain i n p l a c e .

A l l r e s p o n s i b l e sou rces may submit a proposa l , which s h a l l be cons idered by t h e NINCDS, convering one, two o r a l l t h r e e o f t h e s tudy c a t e g o r i e s mentioned above. Review o f MA p roposa l s w i l l be conducted by t h e S c i e n t i f i c Review Branch, NINCDS. The t e c h n i c a l mer i t o f each proposa l w i l l be eva lua ted i n terms o f t h e s tudyrequi rements wi th emphasis on t h e s c i e n t i f i c and a d m i n i s t r a t i v e c a p a b i l i t i e s o f p r o s p e c t i v e o f f e r o r s . Of fe ro r s must be a b l e t o provide conc i se informat ion r ega rd ing t h e i r c a p a b i l i t y t o accrue t h e r equ i r ed number of q u a l i f i e d s u b j e c t ss p e c i f i e d f o r each ca t egory . The t e c h n i c a l e v a l u a t i o n s h a l l a l s o inc lude c o n s i d e r a t i o n of t h e o f f e r o r ' s a v a i l a b l e personnel , f ac i l i t i e s and equipment and t h e

fc._

4

s u i t a b i l i t y o f t h e proposed r e sea rch p l a n s and s t r a t e g i e s t o achieve t h e s tudyo b j e c t i v e s . It is a n t i c i p a t e d t h a t as a r e s u l t o f t h i s MWRFP, a number o f new sources w i l l be awarded MAS and added t o t h e c u r r e n t pool o f MA h o l d e r s .

1 W R F P No. N I H 87-10 w i l l be i s sued on o r about May 1, 1987, w i th r e sponses due af ter 60 days t h e r e a f t e r . Copies of t h e MAAIRFP may be ob ta ined from t h e o f f i c e

%* i d e n t i f i e d below. P lease supply wi th your r eques t two (2) se l f - addres sed mai l ingl a b e l s .

M s . Donna Ro ths t e in Contrac t S p e c i a l i s t Nat iona l I n s t i t u t e o f Neurological and Communicative Disorders and S t roke Federa l Bui ld ing , Room 90 7550 Wisconsin Avenue Bethesda, Maryland 20892

GENETIC BASIS OF REPRODUCTIVE DISORDERS

RFA AVAILABLE: 87-HD-08

P.T. 34; K.W. 0413002, 1002019

Na t iona l I n s t i t u t e o f Chi ld Health and Human Development

App l i ca t ion Receipt Date: August 3, 1987

The Reproductive Sc iences Branch (RSB) o f t h e Center f o r Popula t ion Research (CPR)of t h e Nat iona l I n s t i t u t e of Chi ld Health and Human Development ( N I C H D ) is i n v i t i n gr e s e a r c h g r a n t a p p l i c a t i o n s i n v e s t i g a t i n g t h e g e n e t i c b a s i s of r ep roduc t ived i s o r d e r s . Th i s RFA is t h e f irst N I C H D announcement i n t h e r ep roduc t ive g e n e t i c s area t o be s p e c i f i c a l l y focused on a b e r r a n t g e n e t i c mechanisms c a u s a l l y a s s o c i a t e d wi th i n f e r t i l i t y o r s t e r i l i t y i n m a m m a l s . While a cons ide rab le v a r i e t y o f f u n c t i o n a l d e f e c t s i n t h e mammalian r ep roduc t ive system have been r e p o r t e d t o be g e n e t i c a l l y determined, t h e p r e c i s e n a t u r e o f t h e g e n e t i c sys tem(s1 involved remains , unknown i n a l l but a f e w i n s t a n c e s . App l i ca t ions respons ive t o t h e i n t e n t of t h i s

I RFA w i l l f ocus on d e f e c t i v e g e n e t i c mechanisms c a u s a l l y a s s o c i a t e d wi th mammalian' i n f e r t i l i t y o r s t e r i l i t y . The scope of t h e s e s t u d i e s could inc lude , f o r example, umvmodel s t u d i e s on t h e es tab l i shment o r matura t ion p rocesses o f gonadal germ ce l l s

invo lv ing ova r i an o r t e s t i c u l a r determining f a c t o r s o r genes, f a c t o r s o r genesa s s o c i a t e d wi th oogenes is o r spermatogenesis f a i l u r e , o r g e n e t i c f a c t o r s o r genesc o n t r o l l i n g meios is . The scope would a l s o inc lude s t u d i e s on t h e g e n e t i c b a s i s o f f a m i l i a l agg rega te s o f p o l y c y s t i c ovary d i s e a s e , endometr ios i s , ch ron ic anovu la t ion , o r o t h e r ova r i an o r t e s t i c u l a r dys func t ions d i r e c t l y r e l a t e d t o i n f e r t i l i t y .Responsive a p p l i c a t i o n s w i l l propose t o use t h e most c u r r e n t t echn iques o f modern molecular g e n e t i c s t o d e f i n e t h e gene(s1 involved, c h a r a c t e r i z e t h e i r s t r u c t u r a l /r e g u l a t o r y r o l e i n t h e mechanism and c l a r i f y t h e b i o l o g i c a l consequences o f t h e d e f e c t i v e gene p roduc t ( s1 .

The RFA l a b e l obtained from the NIH staff person l i s t e d below m u s t be a f f i x e d t o t h e bottom of t h e face page. F a i l u r e t o use this l a b e l could r e s u l t i n de layedprocess ing o f your a p p l i c a t i o n such t h a t it may no t r each t h e review committee i n t i m e f o r review.

It is a n t i c i p a t e d t h a t up t o e i g h t ( 8 ) awards w i l l be made announcement through t h e gran t - in-a id ( R o l l mechanism used of t h e d e t a i l e d RFA f u l l y d e s c r i b i n g t h e s p e c i f i c areas o f t h e fo l lowing:

Michael E . McClure, Ph.D. Reproductive Sc iences Branch Center f o r Popula t ion Research Nat iona l I n s t i t u t e of Chi ld Heal th

and Human DevelopmentRoom 7C33, Landow Bui ld ingNat iona l I n s t i t u t e s o f Health Bethesda, Maryland 20892 Telephone: (301) 496-6515

as a r e s u l t o f t h i s by t h e N I C H D . For a copyr e s e a r c h sought, c o n t a c t

5

b’

II

CENTERS FOR INTERDISCIPLINARY RESEARCH ON IMMUNOLOGIC DISEASES

RFA AVAILABLE: 87-AI-15

P.T. 04, 34; K.W. 0710070, 1002004, 1002008, 0710075, 0710100, 0715120, 0715015

Nat iona l I n s t i t u t e of Al le rgy and I n f e c t i o u s Diseases

App l i ca t ion Receipt Date: October 15, 1987

BACKGROUND INFORMATION

The C l i n i c a l Immunology and Immunopathology Branch o f t h e Immunology, A l l e r g i c and Immunologic Diseases Program o f The Nat iona l I n s t i t u t e of Al le rgy and I n f e c t i o u s Diseases ( N I A I D ) suppor t s r e sea rch on t h e c e l l u l a r and molecular mechanisms o f immunologic d i s e a s e s and t h e a p p l i c a t i o n o f t h i s knowledge t o c l i n i c a l problems.For t h i s purpose, s i x Centers f o r I n t e r d i s c i p l i n a r y Research on Immunologic Diseases ( C I R I D ) are c u r r e n t l y funded. This r eques t f o r a p p l i c a t i o n s (RFA) i s in tended t o encourage t h e development of new a p p l i c a t i o n s from c o l l a b o r a t i v e b a s i c s c i ence and c l i n i c a l i n v e s t i g a t i v e groups and t o coord ina te t h e submission o f new C I R I D a p p l i c a t i o n s .

RESEARCH GOALS AND SCOPE

S ince i t s i n c e p t i o n i n 1978, N I A I D ’ s fundamental o b j e c t i v e f o r t h e C I R I D programremains unchanged: a c c e l e r a t i o n o f t h e a p p l i c a t i o n o f knowledge on t h e immune system emerging from r e l e v a n t biomedical s c i e n c e s t o c l i n i c a l i n v e s t i g a t i o n sconcerned wi th asthma, a l l e r g i c d i s e a s e s , and immunologically mediated d i s o r d e r s . The scope of t h e s e C I R I D s is in tended t o inc lude s t u d i e s o f a l l a s p e c t s o f immunologic responses aimed a t d e f i n i n g e t i o l o g i c a l f a c t o r s and pa thogene t i cmechanisms.

Research approaches i n t h i s area inc lude b a s i c and c l i n i c a l immunology s t u d i e s o f acqu i r ed and i n h e r i t e d d i s e a s e s a s s o c i a t e d wi th dys func t ions of t h e immune system(AIDS and Childhood Immune D e f i c i e n c i e s ) ; immunopathology s t u d i e s of t h e g e n e t i c s ,cy to logy , b iochemis t ry , physiology, and pharmacology o f t h e immune system and its d i s o r d e r s (autoimmune d i s o r d e r s ; immune r e l a t i o n s h i p s i n d i a b e t e s , a c u t e and c h r o n i c inflammation (media tors , anti-inflammatory agen t s , chemis t ry and d i s o r d e r s o f complement system, and mechanisms of phagocytos is ) ; and i n v e s t i g a t i o n s concerned wi th a l l e r g i c and h y p e r s e n s i t i v i t y mechanisms (asthma, a l l e r g i c d i s o r d e r s and drug react i o n s 1.

I n a d d i t i o n , a unique f e a t u r e of t h e C I R I D program is a requirement t o implementeduca t iona l o r community a c t i v i t i e s . Within t h e r e s e a r c h framework o f t h e Center , a v a r i e t y o f ou t r each and demonstration p r o j e c t s may be suppor ted . Overa l l , each component p r o j e c t suppor ted under t h e C I R I D g r a n t , whether f o r b a s i c r e sea rch ,c l i n i c a l r e s e a r c h o r ou t r each demonstration p r o j e c t s , it is expected t o c o n t r i b u t e t o , and be d i r e c t l y r e l a t e d t o , t h e o v e r a l l common goa l ; t h e p r o j e c t s should demonstrate an e s s e n t i a l element o f u n i t y and interdependence.

MECHANISM OF SUPPORT

C I R I D g r a n t s are awarded t o an i n s t i t u t i o n on behal f o f a program d i r e c t o r f o r suppor t o f a broadly based, m u l t i - d i s c i p l i n a r y , long-term re sea rch program which mayhave a s p e c i f i c o b j e c t i v e o r b a s i c theme, o r may involve t h e i n t e g r a t i o n of several themes. A C I R I D g e n e r a l l y involves t h e organized e f f o r t s o f groups of i n v e s t i g a t o r swho conduct r e s e a r c h p r o j e c t s r e l a t e d t o t h e o v e r a l l program and of c e r t a i n c o r e r e sources shared by i n d i v i d u a l s where t h e s h a r i n g f a c i l i t a t e s t h e t o t a l r e s e a r c h e f f o r t o f t h e Center . The N I A I D p l a n s t o award a t l eas t two C I R I D g r a n t s du r ingf i s c a l 1988, depending t h e a v a i l a b i l i t y of funds .

_-_\

yea r on

STAFF CONTACT

A more d e t a i l e d RFA may be obta ined

Robert A . Golds te in , M . D . , Ph.D Chief , C l i n i c a l Immunology and Immunopathology Branch, I A I D P Nat iona l I n s t i t u t e of Al le rgy and I n f e c t i o u s Diseases Nat iona l I n s t i t u t e s of Health Westwood Bui ld ing , Room 755 Bethesda, Maryland 20892 Telephone: ( 3 0 1 ) 496-7104

from:

6

Prospec t ive a p p l i c a n t s are encouraged t o submit a one-page l e t t e r o f i n t e n t t h a t i nc ludes a d e s c r i p t i v e t i t l e o f t h e proposed r e s e a r c h and i d e n t i f i c a t i o n of anyo t h e r p a r t i c i p a t i n g i n s t i t u t i o n s . The N I A I D r e q u e s t s such l e t t e r s by June 15, 1987,f o r t h e purpose o f provid ing an i n d i c a t i o n of t h e number and scope o f a p p l i c a t i o n s t o be r ece ived . A l e t t e r o f i n t e n t i s n o t b inding . It w i l l no t e n t e r i n t o t h e review o f any a p p l i c a t i o n subsequently submi t ted and is no t a requirement f o r a p p l i c a t i o n . Let ters o f i n t e n t and i n q u i r i e s should be d i r e c t e d t o D r . Golds te in a t t h e addres s shown above.

The RFA l a b e l ob ta ined from t h e N I H s t a f f person named above must be a f f i x e d t o t h e bottom of t h e face page. F a i l u r e t o use t h i s l a b e l could r e s u l t i n delayedprocess ing of your a p p l i c a t i o n such t h a t it may n o t reach t h e review committee i n t i m e f o r review.

ASTHMA AND ALLERGIC DISEASES CENTERS

RFA AVAILABLE: 87-AI-17

P.T. 04 , 3 4 ; K.W. 0715110, 0710070, 0765035, 1002019, 1003002, 0710100, 0715185

Nat iona l I n s t i t u t e of Allergy and I n f e c t i o u s Diseases

App l i ca t ion Rece ip t Date: October 15, 1987

BACKGROUND INFORMATION

The Asthma and Al l e rgy Branch o f t h e Immunology, A l l e r g i c and Immunologic Diseases Program of t h e Nat iona l I n s t i t u t e of A l l e rgy and I n f e c t i o u s Diseases ( N I A I D ) sponsors fundamental and c l i n i c a l r e sea rch concerned wi th asthma, a l l e r g i c and immunologic d i s e a s e s and wi th r e l e v a n t mechanisms o f h y p e r s e n s i t i v i t y and inflammation. For t h i s purpose, twelve Asthma and A l l e r g i c Diseases Centers (AADC) are c u r r e n t l y funded; suppor t f o r f o u r is scheduled t o conclude i n 1988. Th i s r eques t f o r a p p l i c a t i o n s (RFA) i s in tended t o encourage submissions from c l i n i c a l i n v e s t i g a t i v e groups meeting t h e c r i t e r i a and requi rements f o r an AADC and t o coord ina te review o f new and renewal a p p l i c a t i o n s t h u s p rov id ing e q u i t a b l eoppor tun i ty f o r bo th t o compete f o r funds c u r r e n t l y a v a i l a b l e f o r t h i s programmatica c t i v i t y . RESEARCH GOALS AND SCOPE

The fundamental o b j e c t i v e o f t h e N I A I D ' s AADC rpogram is t o f o s t e r a c c e l e r a t i o n o f t h e a p p l i c a t i o n o f knowledge on t h e immune system emerging from re1evar.t biomedical s c i e n c e s t o c l i n i c a l h y p e r s e n s i t i v i t y d i s o r d e r s . E s p e c i a l l y sought as tile r e q u i s i t ef a c t o r s w i th in a p a r t i c i p a t i n g i n s t i t u t i o n are q u a l i t y r e s e a r c h i n ( a ) b a s i c s c i e n c e ( s 1 , ( b ) c l i n i c a l i n v e s t i g a t i o n suppor ted by adequate c l i n i c a l f a c i l i t i e s and s ta f f e x p e r t i s e i n d i agnos i s and management of a s thma t i c and a l l e r g i c p a t i e n t s , and ( c ) access t o ( a n ) a p p r o p r i a t e p a t i e n t p o p u l a t i o n ( s ) w i th in a s u i t a b l e academic / inves t iga t ive environment designed t o f avor m u l t i d i s c i p l i n a r y i n t e r a c t i on .

The scope o f t h e AADC program r e p r e s e n t s an e f fo r t t o f o s t e r co l l abora t ive approaches t h a t w i l l i n t e g r a t e b a s i c concepts i n a l l e r g y , immunology,pathophysiology, g e n e t i c s , microbiology, b iochemis t ry , b i o s t a t i s t i c s ,b io ins t rumen ta t ion , computer s c i ence and pharmacology i n t o c l i n i c a l i n v e s t i g a t i o n s ,which, i n a d d i t i o n t o t h e f i e l d s o f a l l e r g y and c l i n i c a l immunology, may inc lude such areas as dermatology, rheumatology, i n f e c t i o u s d i s e a s e s , pulmonary medicine,hematology and o torh inolaryngology, when a h igh degree o f r e l evance t o immunologye x i s t s . Because t h e r o l e o f h y p e r s e n s i t i v i t y and immune-related inflammatorymechanisms has become i n c r e a s i n g l y ev iden t i n d i s o r d e r s o f t h e s k i n ,immunodermatologic s t u d i e s are e s p e c i a l l y encouraged wi th in an AADC. Because of t h e alarming i n c r e a s e i n asthma m o r t a l i t y s i n c e 1979, s t u d i e s are a l s o sought t o examine t h i s t r e n d .

Program o b j e c t i v e s are: t o encourage c o l l a b o r a t i o n between b a s i c and c l i n i c a l s c i e n t i s t s ; t o provide a r e sea rch environment f avorab le f o r such i n t e r a c t i o n s ; and t o implement c l i n i c a l a p p l i c a t i o n of adequate ly t e s t e d r e s e a r c h f i n d i n g s and procedures .

I n a d d i t i o n , a f e a t u r e of t h e AADC program is t h e oppor tun i ty f o r d i r e c t o r s t o implement educa t iona l o r community a c t i v i t i e s . Within t h e r e s e a r c h framework o f t h e c e n t e r , a v a r i e t y of out reach and demonstration p r o j e c t s may be suppor ted .

MECHANISM OF SUPPORT

AADC g r a n t s are awarded t o an i n s t i t u t i o n on beha l f o f a program d i r e c t o r f o r t h e suppor t o f a broadly based, m u l t i d i s c i p l i n a r y , long-term r e s e a r c h program which mayhave a s p e c i f i c o b j e c t i v e o r b a s i c theme, os may involve t h e i n t e r g r a t i o n o f s e v e r a l

7

themes. An AADC g e n e r a l l y involves t h e e f f o r t s o f groups o f i n v e s t i g a t o r s who conduct r e s e a r c h r e l a t e d t o t h e o v e r a l l program o b j e c t i v e . The g r a n t can provide suppor t f o r t h e p r o j e c t s and f o r c e r t a i n c o r e r e sources shared by i n d i v i d u a l s where t h e s h a r i n g f a c i l i t a t e s t h e t o t a l r e s e a r c h e f f o r t . Each component p r o j e c t suppor tedunder an AADC g r a n t is expected t o c o n t r i b u t e t o , and be d i r e c t l y r e l a t e d t o , a common theme; t h e component p r o j e c t s should demonstrate an e s s e n t i a l element of

~, u n i t y and in te rdependance . I n f i s c a l yea r 1988, t h e N I A I D p l a n s t o fund a t least fou r new o r competing renewal Asthma and Allergic Disease Center a p p l i c a t i o n s ,depending on t h e a v a i l a b i l i t y o f funds .

STAFF CONTACT

A more d e t a i l e d RFA may be obta ined from:

Dorothy D . Sogn, M.D. Chief , Asthma and Al l e rgy Branch Immunology, A l l e r g i c and Immunologic

Diseases ProgramNat iona l I n s t i t u t e o f A l l e rgy

and I n f e c t i o u s Diseases Westwood Bui ld ing , Room 752 Bethesda, Maryland 20892 Telephone (301) 496-8973

P rospec t ive a p p l i c a n t s are encouraged t o submit a one-page l e t t e r o f i n t e n t t h a t i n c l u d e s a d e s c r i p t i v e t i t l e o f t h e proposed r e s e a r c h and i d e n t i f i c a t i o n of anyo t h e r p a r t i c i p a t i n g i n s t i t u t i o n s . The N I A I D r e q u e s t s such le t ters by June 15, 1987,f o r t h e purpose of provid ing an i n d i c a t i o n o f t h e number and scope o f a p p l i c a t i o n s t o be r ece ived . A l e t t e r o f i n t e n t is n o t b inding . It w i l l no t e n t e r i n t o t h e review o f any a p p l i c a t i o n subsequent ly submi t ted and is no t a necessary requirementf o r a p p l i c a i o n . Letters o f i n t e n t and i n q u i r i e s should be d i r e c t e d t o D r . Sogn a t t h e above addres s .

The RFA l a b e l ob ta ined from t h e N I H s ta f f named above must be a f f i x e d t o t h e bottom o f t h e face page. F a i l u r e t o use t h i s l a b e l could r e s u l t i n delayed p rocess ing o f your a p p l i c a t i o n such t h a t it may n o t r each t h e review committee i n t i m e f o r review.

CORE GRANTS FOR CLINICAL NUTRITION RESEARCH UNITS (CNRUs)

-'RFA AVAILABLE: 87-DK-08

P.T. 34; K.W. 0710095, 0502028, 0730050

Na t iona l I n s t i t u t e o f Diabe tes and Diges t ive and Kidney Diseases Nat iona l I n s t i t u t e on Aging

App l i ca t ion Receipt Date: November 16, 1987

The Nat iona l I n s t i t u t e o f Diabe tes and Diges t ive and Kidney Diseases ( N I D D K ) and t h e National Institute on Aging (NIA) i n v i t e a p p l i c a t i o n s for a C l i n i c a l N u t r i t i o n Research Uni t (CNRU) g r a n t t o be awarded i n Fiscal Year 1988. The award o f one CNRU Grant is a n t i c i p a t e d i n F i s c a l Year 1988.

A CNRU is an i n t e g r a t e d a r r a y of r e s e a r c h , educa t iona l , and s e r v i c e a c t i v i t i e s t h a t is o r i e n t e d toward human n u t r i t i o n i n h e a l t h and d i s e a s e . A r e sea rch c o r e c e n t e r g r a n t is awarded t o f ac i l i t a t e t h e p lanning and coord ina t ion o f t h e ac t i - i t i e s of t h e CNRU p r i m a r i l y by provid ing funding f o r c o r e f a c i l i t i e s and a s s o c i a t e d staff t h a t s e r v e t h e v a r i o u s p r o j e c t s o f t h e CNRU on a shared b a s i s .

ESSENTIAL COMPONENTS OF A CNRU

A CNRU, a t a minimum, must comprise t h e fo l lowing seven components which also should have o t h e r sou rces o f suppor t such as a r e g u l a r N I H r e sea rch g r a n t (Ro l l , N I H FIRST Award (R291, N I H Program P r o j e c t ( P o l ) , N I H I n d i v i d u a l Fellowship (F32), and t h e N I H I n s t i t u t i o n a l Nat iona l Research Se rv ice Award (T32) o r o t h e r Federa l and non-Federal sou rces :

1 Research wi th human s u b j e c t s and popu la t ions ;

2 Laboratory i n v e s t i g a t i o n s ;

3 Research t r a i n i n g ( funds t o be de r ived from o t h e r sou rces ) ;

xu' 4 Shared f a c i l i t i e s and r e sea rch s e r v i c e s ;

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5 Education programs f o r medical s t u d e n t s , house s t a f f , p r a c t i c i n g phys ic i ans ,and a l l i e d h e a l t h personnel ( funds t o be de r ived from o t h e r s o u r c e s ) ;

-, 6 Research components of n u t r i t i o n a l suppor t s e r v i c e s ; and

7 Pub l i c in format ion a c t i v i t i e s ( funds t o be de r ived from o t h e r s o u r c e s . ) 'Ilrr

Funds t o suppor t components 3, 5, and 7 may n o t be r eques t ed as p a r t of an a p p l i c a t i o n i n response t o t h i s announcement.

P o t e n t i a l a p p l i c a n t s are urged t o submit a l e t te r o f i n t e n t r ega rd ing t h e i r a p p l i c a t i o n . The l e t t e r o f i n t e n t is non-binding and is n o t a p recond i t ion f o r an award. I n a d d i t i o n , t h e g e n e r a l d e s c r i p t i o n o f a Core Center, c o p i e s of Core Center Guide l ines , a more d e t a i l e d RFA and c o n s u l t a t i o n may be obta ined from:

Van S. Hubbard, M . D . , Ph.D. Ralph L . Bain, Ph.D. Direc to r , C l i n i c a l N u t r i t i o n Program D i r e c t o r f o r D iges t ive Research Un i t s Program Diseases Centers and A s s i s t a n t Westwood Bui ld ing Room 3A18 Program D i r e c t o r f o r CNRUs Bethesda, Maryland 20892 Westwood Bui ld ing , Room 3A15B Telephone: (301) 496-7823 Bethesda, Maryland 20892

Telephone: (3011 496-9717

For information concerning N I A r e s e a r c h i n t e r e s t s i n n u t r i t i o n c o n t a c t :

Ann Sorenson, Ph.D. Program D i r e c t o r f o r t h e N I A N u t r i t i o n ProgramBui ld ing 31, Room 5C-21 9000 Rockvi l le P ike Bethesda, Maryland 20892 Telephone: (301) 496-1033

The RFA l a b e l ob ta ined from t h e N I H s t a f f persons named above must be a f f i x e d t o t h e bottom o f t h e face page. F a i l u r e to use t h i s l a b e l could r e s u l t i n delayed

.- process ing o f your a p p l i c a t i o n such t h a t it may n o t r each t h e review committee i n ! t i m e f o r review.

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f l I N O R I T Y MENTAL HEALTH RESEARCH CENTERS

P.T. 04, 34, FF; K.W. 0715095, 0710030

Nat iona l I n s t i t u t e o f Mental Health

Appl i ca t ion Receipt Date: October I , 1987

The Nat iona l I n s t i t u t e of Mental Heal th announces t h e a v a i l a b i l i t y o f g r a n t s t o e s t a b l i s h Minority Mental Health Research Centers , announcement no. MH-87-02, t o suppor t coord ina ted , m u l t i d i s c i p l i n a r y r e s e a r c h on t h e mental h e a l t h problems and needs of minor i ty popu la t ions . Sub jec t t o a v a i l a b i l i t y o f funds , t h e I n s t i t u t e w i l l award g r a n t s t o s tudy t h e fo l lowing minor i ty popu la t ions : American Ind ians , Asian Americans, Blacks, Hispanics, and Native Hawaiians and P a c i f i c I s l a n d e r s . Support may be reques ted f o r up t o 5 y e a r s . The o v e r a l l r e s e a r c h p l a n must be c l e a r l y def ined f o r t h e pe r iod of suppor t . App l i ca t ions i n response t o t h i s announcement w i l l be accepted under t h e s i n g l e r e c e i p t d a t e of October 1, 1987. P o t e n t i a l a p p l i c a n t s a r e expected t o submit a l e t t e r of i n t e n t no l a t e r t h a n June 1, 1987,t h a t is no longe r t h a n 10 pages. The l e t t e r of i n t e n t should be s e n t t o :

D r . Freda K . CheungChief , Minority Research Resources Branch Div i s ion o f Biometry and Applied Sc iences Nat iona l I n s t i t u t e of Mental Health 5600 F i s h e r s Lane, Room 18-101 Rockvi l le , Maryland 20857 Telephone: (301) 443-3724

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ADDENDUM

RESEARCH GRANTS RELATED TO PAIN AND ANALGESIA

P.T. 34; K.W. 0715150, 0785015, 0710100

vu’ Alcohol, Drug Abuse, and Mental Heal th Adminis t ra t ion

The Nat iona l I n s t i t u t e o f Mental Heal th ( N I M H ) w a s i n a d v e r t e n t l y omi t ted from t h e program announcement when it w a s o r i g i n a l l y publ i shed i n t h e N I H Guide f o r Grants and C o n t r a c t s on February 6, 1987, Volume 16, No. 5 , pages 6-10. Appl icants who are i n t e r e s t e d i n apply ing for support from NIMH under t h e s u b j e c t program announcement should c o n t a c t :

D r . Susan I . Blumenthal Chief , Behavioral Medicine ProgramNat iona l I n s t i t u t e o f Mental Heal th 5600 F i s h e r s Lane, Room 11C-06 Rockvi l le , Maryland 20857 Telephone: (301) 443-4337

ERRATUM

SOCIAL AND DEMOGRAPHIC RESEARCH ON INFANT MORTALITY AND LOW BIRTHWEIGHT

RFA AVAILABLE: 87-HD-06

P.T. 34; K.W. 0403020, 0404000, 0413001

Nat iona l I n s t i t u t e o f Chi ld Heal th and Human Development

Appl ica t ion Receipt Date: June 15, 1987

Appl icants who have rece ived a mai l ing of t h e f u l l RFA announced i n t h e Guide (Vol.16, No. 11, March 20, 1987) are advised t o n o t e t h a t t h e r e c e i p t d a t e is June 15,1987, n o t May 15, 1987, as s t a t e d i n t h e f u l l RFA.

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L 10 U. S. G . P. 0. 1987-181-289:40040