VITEK® MSMicrobiology Powered

by Mass Spectrometry

DELIVER ACTIONABLE RESULTS TO CLINICIANS TO SUPPORT INFORMED TREATMENT DECISIONS.

TRULY INTEGRATED ID & AST SETUP Simple, step-by-step guided slide preparation for ID and connection with AST using the on-screen VITEK MS Prep Station.

SIMPLE SPOTTINGEasy sample preparation step of spotting organism onto slide and applying sample matrix for bacteria or matrix plus formic acid for yeasts.

FLEXIBLE SAMPLE LOADINGVITEK MS carrier can be loaded with up to four prepared slides and introduced into the instrument. With 48 sample spots per target slide, 192 isolates can be tested per run.

Fast and actionable organism identification provides clinicians with valuable diagnostic information that helps them tailor antimicrobial therapy. Fast identifications combined with stewardship interventions have been shown to reduce time to appropriate therapy in 28 to 44% of cases1 and to reduce hospital length of stay.2

• Safe and effective inactivation and extraction protocols offer excellent performance for identification of pathogenic microorganisms

• Easy workflow with convenient, prepackaged reagent kits

• In-lab solution to save time and costs compared to sending out tests or using other methods

1. Tamma PD, Tan K, Nussenblatt VR, Turnbull AE, Carroll KC, Cosgrove SE. Can matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF) enhance antimicrobial stewardship efforts in the acute care setting? Infect Control Hosp Epidemiol. 2013;34(9): 990 –995. 2. Perez KK, Olsen RJ, Musick WL, et al. Integrating rapid pathogen identification and antimicrobial stewardship significantly decreases hospital costs. Arch Pathol Lab Med. 2013;137(9):1247–1254. 3. Dunne Jr. WM, Doing K, Miller E, et al. Rapid Inactivation of Mycobacterium and Nocardia Species before Identification Using Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry. J Clin Microbiol. 2014;52 (10) 3654-3659.

4. Totty H, Miller E, Moreno E, Dunne WM, Deol P. Comparison of Mechanical Disruption Techniques for Rapid Inactivation of Mycobacterium and Nocardia Species before Identification Using Matrix-Assisted Laser Desorption Ionization–Time of Flight (MALDI-TOF) Mass Spectrometry. J Clin Microbiol. 2016;54 (10) 2626-2627.5. Dunne WMJ, Doing K, Miller E, et al. Rapid Inactivation of Mycobacterium and Nocardia species before identification using Matrix-Assisted Laser Desorption Ionization-Time of Flight mass spectrometry. J Clin Microbiol. 2014;52:3654-3659. 6. U.S. Food & Drug Administration. 510(k) substantial equivalence determination decision summary. https://www.accessdata.fda.gov/cdrh_docs/reviews/K181412.pdf. Accessed March 20, 2019.

References

VITEK® MS

LASERIonizes the sample.

RING ELECTRODEProtein “cloud” is released and accelerated by an electric charge.

TIME-OF-FLIGHTProteins travel up the flight tube before hitting the detector. A long flight tube helps deliver high resolution spectra for increased accuracy.

DETECTORStructural proteins are detected to create a spectrum that represents the protein makeup of each sample.

SPECTRUMA spectra from a sample is carefully digitized using Advanced Spectra Classifier and Weighted Bin Matrix.

ROBUST DATABASEWith more than 15,000 strains and an average of 12 strains per species, the VITEK MS provides highly accurate results.

SAFE EXTRACTION PROCEDURE• No extractions required for routine bacteria and yeast identifications• Simple and reliable inactivation for Mycobacteria, Nocardia and molds3,4

• Studies show no viable organisms after performing inactivation steps5

• Post-inactivation processing steps may be performed in BSL2 lab

HIGH PERFORMANCE• 95.4% Total Combined Correct Identification Results• Mycobacteria – 96.5% correct single choice IDs from patient cultures• Molds – 92.7% accurate single choice IDs with challenge strains6

Mycobacteria Nocardia Molds Bacteria Yeast

FDA 510(k) cleared for 401 organisms — 1,316 total organisms in databaseThe first FDA cleared database for Mycobacteria, Nocardia and molds

Now including Brucella species, Candida auris, and Elizabethkingia anophelis!

Refer to the VITEK MS V3.2 Knowledge Base for the full list of claimed and unclaimed organisms.

• 39 Mycobacteria• 16 Nocardia species• 207 Molds & Yeast• 19 Legionella species

• 43 Streptococcus species• 36 Staphylococcus species• 17 Burkholderia species• 12 Yersinia species

VITEK MS provides identifications in minutes using an innovative mass spectrometry technology — Matrix Assisted Laser Desorption Ionization Time-of-Flight, or MALDI-TOF.

VITEK® MSMicrobiology Powered

by Mass Spectrometry

n Lelliottia amnigena *n Morganella morganiin Pantoea agglomeransn Pantoea dispersa *n Plesiomonas shigelloides *n Pluralibacter gergoviaen Proteus mirabilisn Proteus pennerin Proteus vulgarisn Providencia alcalifaciens *n Providencia rettgerin Providencia rustigianii *n Providencia stuartiin Pseudescherichia (Escherichia) vulneris * n Raoultella ornithinolytican Raoultella planticolan Raoultella terrigena *n Salmonella enterica ssp enterica n Serratia ficaria *n Serratia fonticolan Serratia grimesii *n Serratia liquefaciensn Serratia marcescensn Serratia odoriferan Serratia plymuthica *n Serratia proteamaculans *n Serratia quinivorans *n Serratia rubidaea *n Yersinia aldovae *n Yersinia enterocolitican Yersinia frederikseniin Yersinia intermedian Yersinia kristenseniin Yersinia pseudotuberculosisn Yersinia ruckeri *

GRAM-NEGATIVE FASTIDIOUS

n Aggregatibacter actinomycetemcomitansn Aggregatibacter aphrophilusn Aggregatibacter segnisn Brucella spp *n Campylobacter colin Campylobacter jejunin Campylobacter rectus *n Eikenella corrodensn Haemophilus influenzaen Haemophilus parahaemolyticusn Haemophilus parainfluenzaen Kingella denitrificansn Kingella kingaen Legionella pneumophilan Moraxella catarrhalisn Moraxella lacunata *n Moraxella nonliquefaciens *n Moraxella osloensis *

n Neisseria cinerean Neisseria gonorrhoeaen Neisseria meningitidisn Neisseria mucosa / siccan Oligella ureolytican Oligella urethralis GRAM-NEGATIVE NON-ENTEROBACTERIACEAE

n Achromobacter denitrificansn Achromobacter xylosoxidansn Acinetobacter baumannii *n Acinetobacter calcoaceticus *n Acinetobacter haemolyticusn Acinetobacter johnsonii *n Acinetobacter juniin Acinetobacter lwoffiin Acinetobacter nosocomialis *n Acinetobacter pittii *n Aeromonas hydrophila n Aeromonas jandaei *n Aeromonas punctata (caviae) n Aeromonas sobrian Alcaligenes faecalis ssp faecalisn Bordetella avium *n Bordetella bronchiseptica *n Bordetella parapertussisn Bordetella pertussisn Brevundimonas diminutan Brevundimonas vesicularis *n Burkholderia cenocepacia *n Burkholderia cepacia *n Burkholderia contaminans *n Burkholderia gladioli *n Burkholderia multivoransn Burkholderia vietnamiensis *n Chryseobacterium gleum *n Chryseobacterium indologenesn Comamonas testosteroni *n Delftia acidovorans *n Elizabethkingia anophelis *n Elizabethkingia meningoseptican Elizabethkingia miricola *n Mannheimia haemolytica *n Myroides spp *n Ochrobactrum anthropin Pasteurella aerogenes *n Pasteurella multocidan Pseudomonas aeruginosan Pseudomonas alcaligenes *n Pseudomonas fluorescensn Pseudomonas luteola *n Pseudomonas mendocina *n Pseudomonas oryzihabitans *n Pseudomonas putidan Pseudomonas stutzerin Ralstonia pickettiin Rhizobium radiobacter

ANAEROBES

n Acidipropionibacterium (Propionibacterium) acidipropionici *

n Actinomyces bovis *n Actinomyces israelii *n Actinomyces meyerin Actinomyces naeslundii *n Actinomyces neuiin Actinomyces odontolyticusn Actinotignum schaalii *n Bacteroides caccaen Bacteroides eggerthii *n Bacteroides fragilisn Bacteroides ovatus / xylanisolvensn Bacteroides pyogenes *n Bacteroides stercoris *n Bacteroides thetaiotaomicronn Bacteroides uniformisn Bacteroides vulgatusn Bifidobacterium spp * n Bilophila wadsworthia *n Clostridium baratii *n Clostridium beijerinckii *n Clostridium butyricum *n Clostridium cadaveris *n Clostridium clostridioformen Clostridioides (Clostridium) difficilen Clostridium innocuum *n Clostridium novyi *n Clostridium perfringensn Clostridium ramosumn Clostridium septicum *n Clostridium sporogenes *n Clostridium tertium *n Clostridium tetani *n Cutibacterium acnesn Cutibacterium (Propionibacterium) avidum * n Cutibacterium (Propionibacterium) granulosum *n Finegoldia magnan Fusobacterium mortiferum *n Fusobacterium necrophorumn Fusobacterium nucleatumn Fusobacterium periodonticum *n Hathewaya histolytica *

n Mobiluncus curtisiin Paeniclostridium sordellii * n Paraclostridium bifermentans *n Parvimonas micran Peptoniphilus asaccharolyticusn Peptostreptococcus anaerobiusn Porphyromonas asaccharolytica / uenonis *n Porphyromonas gingivalis *n Prevotella bivian Prevotella buccaen Prevotella denticolan Prevotella intermedian Prevotella loescheii *n Prevotella melaninogenican Prevotella oralis *n Prevotella oris *n Propionibacterium acnesn Pseudopropionibacterium (Propionibacterium) propionicum * n Tannerella forsythia *n Veillonella dispar *

GRAM-NEGATIVE ENTEROBACTERIACEAE

n Cedecea davisae *n Cedecea lapagei *n Cedecea neteri *n Citrobacter amalonaticusn Citrobacter braakiin Citrobacter farmeri *n Citrobacter freundiin Citrobacter koserin Citrobacter youngaen Cronobacter muytjensii *n Cronobacter sakazakii n Cronobacter turicensis *n Edwardsiella hoshinaen Edwardsiella tardan Enterobacter aerogenesn Enterobacter asburiaen Enterobacter cancerogenusn Enterobacter cloacaen Enterobacter hormaechei *n Enterobacter kobei *n Enterobacter ludwigii *n Escherichia colin Escherichia fergusoniin Escherichia hermanniin Ewingella americanan Hafnia alvein Klebsiella oxytocan Klebsiella pneumoniaen Klebsiella variicola *n Kluyvera ascorbata *n Kluyvera cryocrescens *n Kluyvera intermedia *n Leclercia adecarboxylata

VITEK® MS Organism List

n Shewanella putrefaciens *n Sphingobacterium multivorumn Sphingobacterium spiritivorumn Sphingomonas paucimobilisn Stenotrophomonas maltophilian Vibrio alginolyticus *n Vibrio choleraen Vibrio fluvialis *n Vibrio metschnikovii *n Vibrio mimicus *n Vibrio parahaemolyticusn Vibrio vulnificus

GRAM-POSITIVE

n Abiotrophia defectivan Aerococcus viridansn Corynebacterium jeikeiumn Curtobacterium flaccumfaciens *n Enterococcus aviumn Enterococcus casseliflavusn Enterococcus duransn Enterococcus faecalisn Enterococcus faeciumn Enterococcus gallinarumn Enterococcus hirae *n Gardnerella vaginalisn Gemella haemolysansn Gemella morbillorumn Granulicatella adiacensn Kocuria rhizophila *n Lactococcus garvieaen Lactococcus lactisn Leuconostoc mesenteroidesn Leuconostoc pseudomesenteroidesn Listeria monocytogenesn Micrococcus luteusn Pediococcus acidilacticin Rothia mucilaginosan Staphylococcus aureusn Staphylococcus auricularis *n Staphylococcus capitisn Staphylococcus chromogenes *n Staphylococcus cohnii ssp cohniin Staphylococcus cohnii ssp urealyticusn Staphylococcus epidermidisn Staphylococcus haemolyticusn Staphylococcus hominisn Staphylococcus hyicus *n Staphylococcus intermedius *n Staphylococcus kloosii *n Staphylococcus lentus *n Staphylococcus lugdunensisn Staphylococcus pseudintermedius *n Staphylococcus saprophyticusn Staphylococcus schleiferin Staphylococcus sciurin Staphylococcus simulansn Staphylococcus warneri

n Staphylococcus xylosus *n Streptococcus agalactiaen Streptococcus alactolyticus *n Streptococcus anginosusn Streptococcus canis *n Streptococcus constellatusn Streptococcus cristatus *n Streptococcus dysgalactiae ssp dysgalactiaen Streptococcus dysgalactiae ssp equisimilisn Streptococcus equi ssp equi *n Streptococcus equi ssp zooepidemicus *n Streptococcus equinus *n Streptococcus gallolyticus ssp gallolyticusn Streptococcus gallolyticus ssp pasteurianus *n Streptococcus gordonii *n Streptococcus infantarius ssp coli (Str.lutetiensis)n Streptococcus infantarius ssp infantariusn Streptococcus intermediusn Streptococcus mitis / Streptococcus oralisn Streptococcus mutansn Streptococcus parasanguinis *n Streptococcus pneumoniaen Streptococcus pseudoporcinus *n Streptococcus pyogenesn Streptococcus salivarius ssp salivariusn Streptococcus sanguinisn Streptococcus sobrinus *n Streptococcus suis *n Streptococcus uberis *n Streptococcus vestibularis *

MOLDS

n Acremonium sclerotigenumn Alternaria alternatan Aspergillus brasiliensisn Aspergillus calidoustus / ustus n Aspergillus flavus / oryzaen Aspergillus fumigatusn Aspergillus lentulusn Aspergillus nidulansn Aspergillus niger complexn Aspergillus sydowiin Aspergillus terreus complexn Aspergillus versicolorn Blastomyces dermatitidisn Cladophialophora bantianan Coccidioides immitis / posadasiin Curvularia hawaiiensisn Curvularia spiciferan Epidermophyton floccosum

n Exophiala dermatitidisn Exophiala xenobiotican Exserohilum rostratumn Fusarium oxysporum complexn Fusarium proliferatumn Fusarium solani complexn Histoplasma capsulatumn Lecythophora hoffmanniin Lichtheimia corymbiferan Microsporum audouiniin Microsporum canisn Microsporum gypseumn Mucor racemosus complexn Paecilomyces variotii complexn Penicillium chrysogenumn Pseudallescheria boydiin Purpureocillium lilacinumn Rasamsonia argillacea complexn Rhizopus arrhizus complexn Rhizopus microsporus complexn Sarocladium kiliensen Scedosporium apiospermumn Scedosporium prolificansn Sporothrix schenckii complexn Trichophyton interdigitalen Trichophyton rubrumn Trichophyton tonsuransn Trichophyton verrucosumn Trichophyton violaceum

MYCOBACTERIUM

n Mycobacterium abscessusn Mycobacterium aviumn Mycobacterium chelonaen Mycobacterium fortuitum groupn Mycobacterium gordonaen Mycobacterium haemophilumn Mycobacterium immunogenumn Mycobacterium intracellularen Mycobacterium kansasiin Mycobacterium lentiflavumn Mycobacterium malmoensen Mycobacterium marinumn Mycobacterium mucogenicumn Mycobacterium scrofulaceumn Mycobacterium simiaen Mycobacterium smegmatisn Mycobacterium szulgain Mycobacterium tuberculosis complexn Mycobacterium xenopi

NOCARDIA

n Nocardia abscessusn Nocardia africana / nova n Nocardia asteroidesn Nocardia brasiliensis

n Nocardia cyriacigeorgican Nocardia farcinican Nocardia otitidiscaviarumn Nocardia paucivoransn Nocardia pseudobrasiliensisn Nocardia transvalensisn Nocardia veteranan Nocardia wallacei

YEAST

n Candida albicansn Candida auris *n Candida dubliniensisn Candida duobushaemulonii *n Candida famatan Candida glabratan Candida guilliermondiin Candida haemuloniin Candida inconspicuan Candida intermedian Candida kefyrn Candida krusein Candida lambican Candida lipolytican Candida lusitaniaen Candida metapsilosis *n Candida norvegensisn Candida orthopsilosis *n Candida parapsilosisn Candida pelliculosan Candida rugosan Candida tropicalisn Candida utilisn Candida zeylanoidesn Cryptococcus gattii *n Cryptococcus neoformansn Kodamaea ohmerin Malassezia furfurn Malassezia pachydermatisn Rhodotorula mucilaginosan Saccharomyces cerevisiaen Saprochaete capitatan Trichosporon asahiin Trichosporon dermatis / mucoides *n Trichosporon inkin

* Added in V3.2 database update

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VITEK MS is part of bioMérieux’s comprehensive and complementary range of ID/AST solutions for infectious disease diagnostics. Together, VITEK MS, VITEK 2 and ETEST® provide seamless integration and the flexibility needed to optimize laboratory workflow and to support selection of appropriate antimicrobial treatment. Turn data into actionable insights using MYLA®, bioMérieux’s easy-to-use middleware and instrument manager, and increase the value of every test result. bioMérieux’s ID/AST solutions provide confidence in reporting results with speed and accuracy — whether you are faced with routine diagnoses, unusual or resistant organisms, or critical clinical situations.

VITEK® MSMicrobiology Powered

by Mass Spectrometry

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