Visualization of Clinical TrialsCT-eXplorer – Group C

Clinicians and Trial Designers need to:Locate, retrieve, compare, and contrast

trials and subsets of data within the trialsDiscover errors and problems in dataIdentify opportunities for new trials

Progress

November 10 Completion of 2 of projected 4 views

(Qualifying Conditions + Eligibility Criteria) Partially completed Interventions To do: Outcomes

November 30 Ahead of schedule here Dynamic queries and linking are in place

Changes to Design

Learned from user that countries will be represented on a map:Removed country from prototype

Reduced number of displayed qualifying conditions due to screen limitations

Moved trial selector to own pane

In-Progress Solution

Scenario

Pat is designing a trial for Mother to Child Transmission of HIV…

Considers using Zidovudine and Nevirapine delivered together (treatment)

During Pregnancy

B

B

C

B

A

During Labor

A

C

A

D

Post partumTrial

Name

Guay

Connor

Davis

Nevirapine

Zidovudine

Placebo

Didanosine

Total Size

By Arm

LallemantB

A

Interested in testing from 24 weeks gestation (qualifying conditions)

Must ensure no current immunotherapy (eligibility criteria)

Must ensure no current immunotherapy (eligibility criteria) continued…

Needs to understand risks (outcomes)

A

B

B

C

B

A

A

C

A

D

TrialName

Guay

Connor

Dabis

Infant Anemia

Maternal mortality

Infant Mortality

Infant Neutropenia

Maternal neutropia

Maternal anemia

Safety Outcomes

Efficacy Outcomes

Month

WeekInfant HIV infected

Birth 1 2 3 4 5 6 7 8 9

Primary Outcomes

Infant Mortality

Infant Neutropenia

Maternal neutropia

Maternal anemia

Infant HIV infected

Weeks

Infant Anemia

Maternal anemia

Infant Anemia

LallemantB

Infant Anemia

Infant HIV infectedInfant Anemia

Infant HIV infectedInfant Anemia

Infant Neutropenia

Maternal neutropia

Maternal anemia Infant Anemia

Infant Anemia

Challenges

Labels for Eligibility criteria section are not optimalMuch blank space in current approach

Must be very careful with how much we display at one time

Defining query slider behavior must be done with care and user feedback

Thank you!