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Visit www.worldofteaching.com For 100’s of free powerpoints. actin. troponin. actin. tropomyosin. troponin. actin. tropomyosin. troponin. actin. myosin binding site. tropomyosin. troponin. actin. Ca 2+. Ca 2+. Ca 2+. Ca 2+. Ca 2+. Ca 2+. Ca 2+. Ca 2+. - PowerPoint PPT PresentationTRANSCRIPT
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actin
actin troponin
actin troponin
tropomyosin
actin troponin
tropomyosin
actin troponin
tropomyosinmyosin binding site
Ca2+Ca2+ Ca2+ Ca2+
Ca2+Ca2+ Ca2+ Ca2+
Calcium ions are released from the sarcolemma after stimulation from the T system
Ca2+Ca2+
Ca2+
Ca2+
Ca2+Ca2+
Ca2+
Ca2+
the calcium ions bind to the troponin and changes its shape
Ca2+Ca2+
Ca2+
Ca2+
the calcium ions bind to the troponin and changes its shape
Ca2+Ca2+
Ca2+
Ca2+
Ca2+Ca2+
Ca2+
Ca2+
Ca2+Ca2+
Ca2+
Ca2+
the troponin displaces the tropomyosin and exposes the myosin binding sites
Ca2+Ca2+
Ca2+
Ca2+
Ca2+Ca2+
Ca2+
Ca2+
Ca2+Ca2+
Ca2+
Ca2+
the bulbous heads of the myosin attach to the binding sites on the actin filaments
Ca2+Ca2+
Ca2+
Ca2+
Ca2+ Ca2+
Ca2+
Ca2+ Ca2+
Ca2+
the myosin heads change position to achieve a lower energy state and slide the actin filaments past the stationary myosin
Ca2+ Ca2+
Ca2+
APi PiPiAPi PiPiAPi PiPi
Ca2+ Ca2+
Ca2+APi PiPi
APi PiPi
APi PiPi
Ca2+ Ca2+
Ca2+APi PiPi
APi PiPi
APi PiPi
ATP binds to the bulbous heads and causes it to become detached
Ca2+ Ca2+
Ca2+
APi PiPiAPi PiPi
APi PiPi
ATP binds to the bulbous heads and causes it to become detached
Ca2+ Ca2+
Ca2+
APi Pi
Pi
APi Pi
Pi
APi Pi
Pi
hydrolysis of ATP provides the energy to “re-cock” the heads
Ca2+ Ca2+
Ca2+
APi Pi
Pi
APi Pi
Pi
APi Pi
Pi
hydrolysis of ATP provides the energy to “re-cock” the heads
Ca2+ Ca2+Ca2+
APi Pi
Pi
APi Pi
Pi
APi Pi
Pi
Ca2+ Ca2+Ca2+
APi Pi
Pi
APi Pi
Pi
APi Pi
Pi
calcium ions are re-absorbed back into the T system
APi Pi
Pi
APi Pi
Pi
APi Pi
Pi
calcium ions are re-absorbed back into the T system
APi Pi
Pi
APi Pi
Pi
APi Pi
Pi
the troponin reverts to its normal shape and the tropomyosin move back to block the myosin binding sites
APi Pi
Pi
APi Pi
Pi
APi Pi
Pi
the troponin reverts to its normal shape and the tropomyosin move back to block the myosin binding sites
APi Pi
Pi
APi Pi
Pi
APi Pi
Pi
the troponin reverts to its normal shape and the tropomyosin move back to block the myosin binding sites
APi Pi
Pi
APi Pi
Pi
APi Pi
Pi
phosphocreatine regenerates ATP
APi Pi
PiAPi PiPi
APi PiPi
phosphocreatine regenerates ATP
APi PiPiAPi PiPi
APi PiPi
phosphocreatine regenerates ATP