viruses - noelways.com€¦ · web viewviron morphology • icosahedral * polio virus • helical...

Microbiology Student Outline - Viruses

Viruses

Chapter 13

1. Viruses

• Obligate Intracellular Parasites (p. 368)

A. Results

i. Cell Death

ii. Cell Proliferation

iii. Altered Cell Differentiation

iv. No Change

B. Anatomy of a Viron Particle (p. 370 - 376)

i. Nucleocapsid

a. Nucleic Acid

• dsDNA

• ssDNA

• dsRNA

• ssRNA

• Segmented Genome


b. Capsid

• Capsomeres

• Enzymes

• Spikes

* Hemagglutinin

* Neuraminidase

c. Envelope

d. Viron Morphology

• Icosahedral

* Polio Virus

• Helical

* Rabies

• Complex (Bacteriophages)


e. Viral Culturing

• Animal Viruses

* Living Animals

* Embryonated Eggs

* Tissue Culture

2. General Viral Life Cycle (Pull out handout on Viral Lifecycle)

A. Adsorption (Attachment)

B. Penetration

i. Engulfment (endocytosis)

ii. Fusion of Envelope

iii. Injection

C. Uncoating and Nucleic Acid Release

D. Replication (Biosynthesis)

E. Assembly (Maturation)

F. Release

i. Lysis

ii. Budding

iii. Exocytosis


3. Viral Effects

A. Inclusion Bodies

B. Block Synthesis in Host

C. Asymptomatic Latent Viral Infection

4. Bacteriophages (p. 380 - 383)

A. Morphology

i. Filamentous

ii. Complex

B. Alternation of Lytic and Lysogenic Cycle (see also Bacterial Genetics Handout)

i. Lytic Cycle

ii. Lysogenic Cycle

a. Temperate Phage (Prophage)

iii. Phage Conversion (or Lysogenic Conversion)

C. Temperate Phages

i. Corynebacterium diphtheriae (Diphtheria)

ii. Streptococcus pyogenes (Scarlet Fever)

iii. Clostridium botulinum (Botulism)

D. Temperate Phages and Specialized (Restricted) Transduction


5. RNA Viruses (p. 388)

A. ssRNA Viruses

i. Sense (+) Strand Antisense (-) Strand

ii. Antisense (-) Strand Sense (+) Strand

B. dsRNA Viruses

6. Retro Viruses (p. 390)

A. Reverse Transcriptase (RNA DNA)

B. Provirus

C. Budding

7. Cancer and Viruses (pp. 389 - 392)

A. Oncogenes

B. Oncogenic Virus

C. Transformation

D. DNA Oncogenic Virus Example: Hepatitis B Liver Cancer

8. Latent Viral Infections (p. 392)

A. Herpes Virus

i. Fever Blisters

B. Varacella-Zoster

9. Prions (p. 392 - 393)


A. Examples

i. Mad Cow Disease

ii. Creutzfeldt-Jakob Disease (CJD)

B. Mechanism

viruses - noelways.com€¦ · web viewviron morphology • icosahedral * polio virus • helical...

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