vectorborne diseases in north america · tickborne diseases in north america ixodes scapularis, i....
TRANSCRIPT
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Vectorborne Diseases in
North AmericaAlfred DeMaria, Jr., M.D.
Massachusetts Department of Public Health
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Presenter Disclosure InformationAlfred DeMaria, Jr., M.D.
Consultant No relevant conflicts of interest to declare
Grant Research/Support No relevant conflicts of interest to declare
Speaker’s Bureau No relevant conflicts of interest to declare
Major Stockholder No relevant conflicts of interest to declare
Other Financial or Material Interest No relevant conflicts of interest to declare
No recommendations for off-label use of drugs or devices.
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Coverage
Ticks
Mosquitoes
Flys, fleas and mites less important in North America, and not covered
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Vectorborne Diseases
Need reservoir – human or other speciesNeed competent vectorUsually particular to the infecting organism
Infectious agent has life cycle in vertebrate host and vectorNot acting as a needle and syringe
Seasonality related to weather and climate
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Mosquitoes Versus Ticks Mosquitoes
Insects3 body parts (head,
thorax, abdomen)Antennae6 legsWings (can fly)
Siphons blood from vessels
Feeds to reproduceMultiple life stages
TicksArachnidsOne body partNo antennae8 legs (except earliest stage)
Can’t jump
No wings (can’t fly)
Injures, slurps bloodFeeds to develop and
reproduceMultiple life stages
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Tickborne Diseases in North AmericaIxodes scapularis, I. pacificus
Lyme Borreliosis (Borrelia burgdorferi) Babesiosis (Babesia microti, Babesia duncani, Babesia sp. WA-1 and MO-1) Anaplasmosis (HGE – Anaplasma phagocytophilum) Borrelia miyamotoi
Amblyomma americanum Ehrlichiosis (HME - Ehrlichia chaffeensis) Southern, tick associated rash illness (STARI, Master’s disease)
Dermacentor andersoni, D. variabilis Tularemia (Francisella tularensis) Rocky Mountain spotted fever (Rickettsia rickettsii) Colorado tick fever (group A Coltivirus)
Ornithodoros sp. Relapsing fever (Borellia sp.)
Ixodes cookei (? I. scapularis) Powassan virus encephalitis
Tick paralysis (tick neurotoxin)
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Factors Associated with Increasing Risk of Lyme other Tickborne DiseasesIncreased deer populationIncreased black-legged tick populationFragmented forest environmentIncreased white-footed mouse populationIncreased risk of mouse infectionExpansion of habitatLoss of biodiversity
More people exposed to “ticky” habitat
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Reported Cases of Lyme Disease—United States, 2011
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Number of Confirmed Cases of Lyme Disease Reported in Massachusetts By Year, 1997-2012
MDPH Office of Integrated Surveillance and Informatics Services(as of May 21, 2013)
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Confirmed Lyme disease cases by age and sex--United States, 2001-2010
CDC
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N=1728MDPH Office of Integrated Surveillance and Informatics Services
Number of Confirmed Lyme Disease Cases Reported in Massachusetts, by Month of Onset, 2011
0100200300400500600
JAN FEB MAR APR MAY JUN JUL AUG SEP OCT NOV DEC
Month of Diagnosis
Num
ber o
f Con
firm
ed
Cas
es
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Hildenbrand, et al. Lyme Neuroborreliosis: Manifestations of a Rapidly Emerging Zoonosis. American Journal of Neuroradiology 30:1079-1087, June-July 2009
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van Burgel, et al. Severe course of Lyme neuroborreliosis in an HIV-1 positive patient; case report and review of the literature. BMC Neurol. 2010; 10: 117.
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Chronic Lyme Disease
Chronic neurological and musculoskeletal symptoms of chronic Lyme disease are well described
Post-Lyme disease chronic symptoms are a subject of intense and acrimonious controversyConflicting treatment studies and questionsConflicting treatment guidelines
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Chronic Neurologic Manifestations of Lyme DiseaseLogigian, Kaplan and Steere, NEJM 1990 323:1438-44.
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The Long-Term Outcome of Lyme DiseaseShadick, et al. Ann Intern Med 1994; 121: 560-567.
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Diagnosis of Lyme DiseaseClinicalSigns and symptomsNon-specific tests: ESR, ALT/AST, CSF
LaboratoryTwo-tiered, EIA or IFA and Western blotIsolation of Borellia burgdorferi (modified
Barbour-Stoenner-Kelly medium)Polymerase chain reaction (PCR, real time PCR) Antigen tests (OSPA, OSPB, flagellin, etc.)
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Recommended Treatment of Lyme Disease
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Erythema Migrans at the Site of an Ixodes scapularis Tick Bite in 482 Subjects
Nadelman, R. B. et al. N Engl J Med 2001;345:79-84
Adverse events: 30 versus 11%
87% (25-98%) protective
re EM
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Prophylaxis Recommendations
Single dose 200 mg doxycyclineWithin 72 hours of discovery of attached tickLyme disease endemicObviously engorged tickAttached >36 hours
No recommendation for childrenMust always counsel about erythema migrans and
symptoms
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Babesiosis“Nantucket fever”Parasite, Babesia microti and other speciesInvades red blood cellsSigns and symptomsUsually none (therefore may donate blood)Those at risk develop fever (often high), chills
and anemiaRisk factorsLack of spleenImmune deficiencyAge (very young, very old)
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Confirmed and Probable Babesiosis in Massachusetts
(as of May 21, 2013) MDPH Office of Integrated Surveillance and Informatics Services
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Atovaquone plus azithromycin or clindamycin plus quinine
Severely ill patients with high parasitemia and asplenic patients with life-threatening illness should be considered for exchange transfusion
Babesiosis: Treatment
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© 2012 American Society of
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Confirmed and Probable Anaplasmosis Reported in Massachusetts
MDPH Office of Integrated Surveillance and Informatics Services(as of May 21, 2013)
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Anaplasmosis
Incubation period is 1 to 2 weeksMild signs or none at all Fever, headache, muscle aches,
chills, sweating, nausea, and vomiting
More severe complications are associated with older age, diabetes, immunocompromise, delayed treatment
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Treatment of Anaplasmosis
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Human Monocytic Ehrlichiosis (HME)
Ehrlichia chaffeensisTransmitted primarily by Ambylomma
americanum (lone star tick) – sometimes other ticks
Southern, South-Central and Atlantic statesFever, headache, malaise and myalgiaRash – petechial to maculopapularThrombocytopenia, leukopenia, elevated
transaminases
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Rocky Mountain Spotted Fever
Transmitted by wood and dog ticks (Dermacentor sp.)
Incubation period is 5-7 days Fever, severe headache, myalgia,
confusion, photophobia, nausea, vomiting and anorexia
In ~80% of cases, a maculopapular rash on the extremities will appear 3-5 days after fever onset and rapidly spread to the trunk
The characteristic petechial rash is usually not seen until the sixth day or later
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Tularemia Francisella tularensis - non-motile, facultative,
Gram-negative, coccobacillus Intracellular pathogen Usually zoonotic – ticks (Dermacenter), biting flies,
direct contact, fleas, inhalation, ingestion of meat, other food and water
Prevalence in wild rabbits may be up to 1% Immune animals may clear ticks of infection Transovarian transmission in ticks
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Reported cases of tularemia -- United States, 2000-2008
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Tularemia: TreatmentTreatmentstreptomycin or gentamicintetracycline and chloramphenicol active, but
associated with relapsesJarish-Herxheimer-like reactionsdeath rate 4% or less with treatment
VaccineIND (live, attenuated)Need CMI response
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Powassan VirusNorth American flavivirusTransmitted by Ixodes cookei, but other ticks also
implicatedHigh seroprevalence in burrowing mammals in New
EnglandRare disease in humans – but severe illness
associated with marked neurological sequelae and 10-15% case-fatality rate
Increased recognition with increased evaluation of encephalitis because of WNV
Related virus isolated from I. scapularis by Telford, et al
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DEETNever use more than 30%Raises likelihood of adverse eventDoesn’t offer significant added benefit
Not for children <2 months oldEffectiveness time varies with temperature,
perspiration and water exposure
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Mosquitoborne Diseases in North America
In North America viral diseases Endemic diseases order of incidence, in U.S., in 2011
West Nile virus (WNV) LaCrosse (LAC) virus St. Louis encephalitis (SLE) virus Eastern equine encephalitis (EEE) virus Jamestown Canyon virus (JCV)Western equine encephalitis (WEE) virus
Emerging threats Dengue Yellow fever
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also SLE
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Massachusetts 1970-2012Human EEE and EEEV Mosquito Isolates
Human Outbreak Cycle 1938-2006, mean 13 years (7-19) Aerial spray
1973-75 1990 2006 2010 2012
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Eastern Equine Encephalitis Virus
Alphavirus genus, family Togaviridae First isolated in 1933 First human case confirmed by isolation from
brain tissue in 1938 Culiseta melanura is primary enzootic vector Aedes vexans, Aedes canadensis, Coquillettidia
perturbans are putative bridge vectors Passerine birds are primary amplifying hosts
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Eastern Equine EncephalitisClinical Course
Abrupt onset fever, chills, headache, muscle aches, nausea and vomiting
Progressive disorientation, discoordinationSeizures, coma~30-50% mortality~80% residual neurological deficits
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Magnetic resonance images (MRIs) and computed tomography (CT) neuroradiographs showing lesions in brains of 3 children with eastern equine encephalitis.Silverman, et al. EID 2013; 19: 194-201.
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Association of Length of Prodrome with Clinical Outcome in Children with Eastern Equine Encephalitis
Silverman, et al. EID 2013; 19: 194-201.
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EEE Activity in the U.S (as of October 30, 2012)
CDC
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West Nile Virus
Isolated from woman with fever, West Nile region, Northern Province, Uganda, 1937
First epidemic described: Israel, 1950Multiple strains, widely endemic - Middle East,
Africa, Asia, Europe, Australia, and now North America
Broad range of hosts: birds, mammalsHuman infection common in endemic areas
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West Nile VirusNew York City, 1999
First appearance in North America, Summer of 1999
62 confirmed and probable cases, 7 deathsSerosurveys suggest widespread,
unrecognized, human infectionSevere disease and deaths in birds and horses
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West Nile Virus InfectionHuman Disease
Incubation period 5 to 15 daysHeadache, sore throat, fatigue, myalgia,
arthralgia, fever (moderate to high), conjunctivitis, lymphadenopathy
Rash (roseolar) more common than with other flaviviruses
Muscle weakness, often profoundAseptic meningitis, encephalitis,
meningoencephalitisMyocarditis, hepatitis, pancreatitisMild and sub-clinical infection very common, age-
related severity
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WNV Encephalitis/Infection and Clinical/Sub-Clinical Ratios
Area Year(s)Encephalitis/
InfectionClinical/
Sub-Clinical
Israel 1950s 1:100 -
Romania 1996 1:331 -
Czechland 1997 - 1:1.6
NYC 1999 1:139 1:4.8
Staten Island2000
1:157
Suffolk Co., NY 2000 1:>121
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Culex restuansCulex pipiens
Culex salinarius Aedes vexans
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West Nile virus (WNV) ActivityUnited States, 2012
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West Nile VirusLaboratory Confirmation
WNV isolation (virus identified by IFA, neutralization, RT-PCR or sequencing)
RT-PCR using multiple primersCaptured WNV antigen IgM by capture EIA IgG by EIA, HI or neutralization test Identification of WNV antigen or genome in
tissue
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West Nile VirusEmerged Issues
Transfusion and organ transplant transmission
Intra-utero/congenital infectionBreast milkOccupational exposure/transmissionAcute flaccid paralysis
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WNV Acute Flaccid ParalysisVersus Guillain-Barré Syndrome
GBS WNV-AFPFollows infection/syndromeFever, leukocytosis absentConcurrent encephalopathy absent
Acute phase of infectionFever, leukocytosis presentConcurrent encephalopathy frequent
Symmetric usually Asymmetric generallySensory change/paresthesia No sensory componentCSF without cells, protein elevated CSF with cells and elevated proteinEMG/NCS consistent with demyelination
EMG/NCS consistent with pure motor deficit
Treated with IVIG, anticoagulation, plasmapheresis, high dose steroids
GBS treatment would be detrimental
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St. Louis Encephalitis Virus Neuroinvasive Disease Cases Reported by State, 1964-2010
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California Serogroup Virus Neuroinvasive Disease Cases Reported by State, 1964-2010
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Percent of Human WNV and EEE Cases in Massachusetts, 2001-2012, by Age Group
0
5
10
15
20
25
<10 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+
Age Group (Years)
Perc
ent o
f Con
firm
ed C
ases
EEE WNV
California sero-group/LAC SLE
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Prevention Reduce mosquito exposure
Window and door screensMosquito netting Staying indoors at peak mosquito times
Reduce mosquito bites Clothing Repellents
DEET (N-N-diethyl-meta-toluamide) PicaridinOil of lemon eucalyptus Permethrin
Reduce mosquitoes Reduce standing waterMosquito control
Reducing breeding environmentLarvicidingAdulticiding
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What’s Next in Mosquitoes?Togaviruses
Eastern equine Western equine Venezuelan Chikungunya Sindbis Ross River
Flaviviruses West Nile St. Louis Dengue Yellow fever Japanese Murray Valley
BunyavirusesCalifornia group (LaCrosse, Jamestown Canyon, etc.)Cache ValleyTensawRift ValleyOther?
Here, now
Could come
Unlikely
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Aedes aegypti
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WHO
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Yellow Fever
FlavivirusMost infections asymptomatic Incubation period for symptoms is 3-6 daysAcute onset of fever, chills, headache, back
pain, myalgias, nausea and vomiting, and weakness
In 15% of symptomatic cases, recurrent high fever, with potential for jaundice, hemorrhage, shock and multi=organ failure
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Areas with Yellow Fever
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Aedes albopictus
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Distribution of Aedes albopictusthe Asian Tiger Mosquito
Charrel R et al. N Engl J Med 2007;356:769-771
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ChikungunyaAlphavirus – similar to Sindbis, MayaroMany competent mosquito vectors Epidemic polyarthritisRash follows arthritisMild hemorrhagic manifestations Imported cases in the United StatesQuestion of potential transmission in the United
States
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Chikungunya: Origins and IntroductionsWeaver SC, Reisen WK. Antiviral Res. 2010; 85:328-45.
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