vasculogenesis and angiogenesis integrins in vasculature and ko phenotypes
DESCRIPTION
Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes Growth Factor Receptors signaling and vasculature phenotypes VEGFR Tip cells VEGF, Notch. Vasculogesis and angiogenesis in vertebrates. Models Intussuseptive angiogenesis - PowerPoint PPT PresentationTRANSCRIPT
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Vasculogenesis and angiogenesis
Integrins in vasculature and KO phenotypes
Growth Factor Receptors signaling and vasculature phenotypesVEGFRTip cells VEGF, Notch
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Vasculogesis and angiogenesis in vertebrates
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Models Intussuseptive angiogenesis
(tissues as muscle, often blood flow dependent etc.)
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Angiogenesis is a dynamic and context determined process
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Examples of vascular defects
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Integrins in the vasculature
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L1CAMA7Lm68% embryonic lethal hemorrgaged E10-14.5 SM cells
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Integrin inhibitors and RTK agonistic interactions (Kaan)
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Angiopoitins, Tie1 and Tie2 receptor
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PDGF RTK signaling
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VEGF RTK signaling
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VEGFR3 at tips cells
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Signaling in sprouting tip cells
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Delta-Notch signaling
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Sema3 inhibits integrin function. Normal angiogenesissemaphorins
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Mouse models affecting TGFbeta signaling
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Haemodynamics affect vascular remodellingexample
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Pixt2 KO phenotypes in 6th BAAOcclusion of right BAAs results in Persistence of left 6 BAA