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The Safety

W

Bradford L. Felker, M.D.

Kevin L. Sloan, M.D.

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valproic acid is a rare and potentially fa

(46). Concerns about hepatotoxicit

warnings that valproic acid shou ld n

tients with significant hepatic dysfunc

The hepatitis C virus is one of the moof chronic viral hepatitis (9). Once he

has been established, disease status i

histologic biopsy (10, 11). Because seri

i d i i l l

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BRIEF REPORTS

TABLE 1. Characteristics and Changes in Acid, by Hepatitis C Status, and for Comp

Characteristic

UnHe

Statu

N

Male 227

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Significant Difference Among

Patients With Positive

Hepatitis C Status: Valproic AcidVersus Lithium/GabapentinVersus Antidepressants

Patie

AcidStatStatus V

2 df p 2

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BRIEF REPORTS

14. Rosenberg SD, Goodman LA, Osher FC, Sw

Butterfield MI, Constantine NT, Wolford G

lence of HIV, hepatitis B, and hepatitis C in

mental illness. Am J Public Health 2001; 9

15. Saxon AJ, Sloan KL, Reoux J, Haver VL: Sa

patients with abnormal liver function te

1998; 59:313316