validation of a simulation model for laparoscopic ...filling an educational gap in procedure-based...
TRANSCRIPT
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Validation of a Simulation Model For Laparoscopic
Myomectomy Developed with 3D-Printed Molds
Amanda Behr, MA, CMI, CCA; Miller Singleton, BS; Kelli Braun, MD, FACOG; Robert Stager, MD, FACOG
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DISCLOSURES
We have no actual or potential conflicts of interest in relation to this program or
presentation.
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BUT FIRST…A THANK YOU!
Department of Obstetrics and Gynecology, Section of General Obstetrics and
Gynecology
Medical Illustration Graduate Program
Medical Summer Scholars Program
Educational Innovation Institute
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OBJECTIVES
1. Describe the role of 3D printing in the medical field.
2. List the various materials and the steps used in the process of creating a realistic uterine model.
3. Discuss the aspects of the model that required troubleshooting and any modifications that were made.
4. Explain the importance of interprofessionalcollaboration in the development of the model.
5. Discuss any future plans or areas of research involving the uterine model as well as other anatomic models.
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3D PRINTING: THE RISE TO FAME
Invented by physicist Charles Hull in 1986
Originally used by the manufacturing industry to create product prototypes
“...a method and apparatus for making solid objects by successively ‘printing’ thin
layers of the ultraviolet curable material one on top of the other.” – Charles Hull
The technology entered into the medical field in the early 2000s
Used to create dental implants and custom prosthetics
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3D PRINTING: THE RISE TO FAME
“A very powerful tool that can create anything.”
Charles Hull
MakerBot
Replicator
$2,499
(Amazon)
LulzBot Mini
$1,250
(Amazon)
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CURRENT APPLICATIONS IN THE MEDICAL FIELD
How is 3D printing revolutionizing the
medical field?
Customization and Personalization
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3D PRINTER IN ACTION
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TYPES OF 3D PRINTERS
Filament, Fused Deposition Modeling (FDM)
Plastic filament heated an deposited in layers
Light cured resin, Stereolithography (SLA)
Laser cures liquid resin
High resolution
Polyjet (PJ)
Deposited photopolymer in layers like an inkjet printer
High-resolution
Selective Laser Sintering (SLS)
Laser cures a powder
Nylon, ceramics, glass, metals
FDM Printing Schematic
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Garcia, J. et
al, 2017
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Garcia, J. et
al, 2017
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Full Color
Multi-material
Garcia, J. et
al, 2017
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CURRENT APPLICATIONS IN THE MEDICAL FIELD
Tracheal Splints
(University of Michigan)Prosthetics
(University of Toronto)
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CURRENT APPLICATIONS IN THE MEDICAL FIELD
Microporous Scaffolds Seeded with Ovarian
Follicles
(Northwestern University)
Cranium Replacement
(University Medical Center in Utrecht)
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CURRENT APPLICATIONS IN MEDICAL EDUCATION
Forbes: The State of 3D Printing, 2017
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ANATOMICAL MODELS FOR SURGICAL TRAINING
Pre-Surgical Planning of Complex Cases
Patient-specific model generated using CT/MRI data
Printed with resin that resembles the organ(s) of choice
Perica E and Sun Z., 2017Polyjet printing
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ANATOMICAL MODELS FOR SURGICAL TRAINING
Liver parenchyma (transparent)
Inferior vena cava and hepatic
veins (purple)
Portal vein (blue)
Tumor and hepatic arterial supply
(pink)
Perica E and Sun Z., 2017
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ANATOMICAL MODELS FOR SURGICAL TRAINING
Resident Simulation Training
Cost-effective method of producing simulation models that demonstrate the
anatomical and pathological characteristics of a disease process
When combined with the use of silicone and other modeling agents, 3D printing
can create specific devices resembling the haptic properties of the organ(s) of
choice
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ANATOMICAL MODELS FOR SURGICAL TRAINING
FDM
SLS
SiliconePolyjet
Manning, T.G. et al, 2018
Garcia, J. et al, 2017
Lichtenstein, J.T. et al, 2017
Bartellas, M. et al, 2017
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FILLING AN EDUCATIONAL GAP
Uterine fibroids are the most common benign uterine tumors in women
For symptomatic patients who want to preserve fertility, laparoscopic myomectomy
(LM) my be indicated
LM requires advanced surgical skill in order to successfully complete fibroid
excision and laparoscopic suturing
Procedural difficulty and lack of provider comfort has led to decreased exposure of
LM in residency programs
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FILLING AN EDUCATIONAL GAP
In procedure-based residency programs, surgical simulation is an essential component
to residents’ training
For training in LM, limited commercial simulation products for LM exist and are cost-
prohibitive for consistent use
Thus, our research questions was as follows:
Can we use 3D printing in combination with other modeling agents (silicone, etc.) to
create a cost-effective simulation model for LM?
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MATERIALS AND METHODS: DIGITAL DESIGN
A fibroid uterus computer model was generated using Pixelogic® Z-brush design
software
The model consisted of the following:
Uterine body
4 fundal subserosal fibroids (2 anteriorly and 2 posteriorly)
Fallopian tubes
Round ligament
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UTERINE MODEL FOR LAPAROSCOPIC MYOMECTOMY
Fallopian tube
Round ligament
Fibroid
Velcro to fasten it in the trainer box
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MATERIALS AND METHODS: DIGITAL DESIGN
Preliminary model generated in Z-brush
Fallopian tube
Round ligament
Fibroid
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MATERIALS AND METHODS: TEST PRINT
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MATERIALS AND METHODS: TEST PRINT
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MATERIALS AND METHODS: MOLD DESIGN
The positive shape of the uterus was subtracted from a four-part mold design
The four parts of the mold include:
Two main pieces that close to form the body
Two pieces to avoid entrapment of the fallopian tubes
The fibroids required an additional two-part mold
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Top Uterine Mold Bottom Uterine Mold
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Uterine Fibroid Mold
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MATERIALS AND METHODS: 3D PRINTING
The molds were exported as a
STereoLithography (STL) file
STL file was uploaded to Ultimaker®
Cura software
The molds were printed from a LulzBot
TAZ 6 3D printer using polylactic acid
3mm filament
LulzBotTAZ 6 3D Printer (+ kit $5,000)
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MATERIALS AND METHODS: CASTING THE MODEL
Smooth-On Dragon Skin 10® with a durameter of 10 was used for the uterus
Smooth-On Dragon Skin 30® with a durameter of 30 was used to create the fibroids
Utilizing silicone of different durameters contributed to the distinct haptic
properties of the model
Factor II Functional Intrinsic II- Silicone Coloring System was used to add realistic
color to the uterus and the fibroids
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MATERIALS AND METHODS: CASTING THE MODEL
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MATERIALS AND METHODS: CASTING THE MODEL
Uterine Molds Uterine Fibroid Molds
Durameter of Silicone 10 30
Quantity of Silicone ~400 grams ~100 grams
Cure Time ~15 minutes ~15 minutes
Set Time 2.5 - 3 hours 1 hour
Workflow Silicone painted in molds cure
placement of fibroids fill with
remaining silicone set
Silicone poured into molds cure
set
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Picture of molds
Top Uterine Mold
Bottom Uterine Mold
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MATERIALS AND METHODS: TOTAL COST
5 uterine models with 4 fibroids each
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MATERIALS AND METHODS: VALIDATING THE MODEL
Velcro was sutured into the base of each
model in order to fasten it in the
simulation trainer box
Residents evaluated the model and its
effectiveness in simulating LM upon
simulation completion
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MATERIALS AND METHODS: VALIDATING THE MODEL
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MATERIALS AND METHODS: VALIDATING THE MODEL
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MATERIALS AND METHODS: VALIDATING THE MODEL
Thirteen residents evaluated the model
upon completing the simulation
The evaluation was presented as a 5-
point Likert scale with 1 meaning
“strongly disagree” and 5 meaning
“strongly agree”
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MATERIALS AND METHODS: VALIDATING THE MODEL
Resident Responses (N=13)
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TROUBLESHOOTING AND MODIFICATIONS
Compatibility with surgical instruments
A cautery is the typical surgical device used in the procedure
However, a cautery requires organic material to initiate the appropriate reaction
Uterine model lacked organic material
Tofuterus? Perhaps in the future
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TROUBLESHOOTING AND MODIFICATIONS
Solution: Use a harmonic scalpel during the
simulation
Utilizes ultrasonic vibration, rather than
an electric current, to cut and cauterize
tissues
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TROUBLESHOOTING AND MODIFICATIONS
Fibroid adherence to the “myometrium”
During the simulation test, residents found that the base of the fibroid adhered to
the ”myometrium,” making it difficult to excise
Fibroids were initially coated in a separator (dish soap)
Too little separator?
Inadequate mixing of the separator? (typically 1:1)
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TROUBLESHOOTING AND MODIFICATIONS
Solution: Careful mixing of the dish
soap/water mixture
Solution: Place a small piece of Saran
Wrap® behind the fibroid to facilitate
excision
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TROUBLESHOOTING AND MODIFICATIONS
3D printer malfunction
Still unsure of the exact cause of
malfunction
Misalignment?
Overuse?
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TROUBLESHOOTING AND MODIFICATIONS
Solution: Outsource the design!
www.3dhubs.com
www.makexyz.com
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REPAIR AND REUSE
To make the model more economical, we devised a method to repair the model with
silicone and Saran Wrap®
Reuse the fibroids
Re-cast with silicone
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INTERPROFESSIONAL COLLABORATION
Members of the Team
Ob-Gyn Clinicians
Medical Illustrators
Ob-Gyn Residents
Medical Students
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IMPORTANCE OF INTERPROFESSIONAL COLLABORATION
We recommend a multidisciplinary team approach for production of
simulation models
Provides an ideal combination of medical sculpture knowledge and
clinical skills
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FUTURE AREAS OF RESEARCH
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FUTURE AREAS OF RESEARCH
What is the NIH 3D Print Exchange?
“Few scientific 3D-printable models are available online, and the
expertise required to generate and validate such models remains
a barrier. The NIH 3D Print Exchange eliminates this gap with an
open, comprehensive, and interactive website for searching,
browsing, downloading, and sharing biomedical 3D print files,
modeling tutorials, and educational material.”
https://3dprint.nih.gov/
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CREATE A PATIENT-SPECIFIC MODEL FROM IMAGING DATA
Garcia, J. et al, 2017
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3D ULTRASOUND FOR PATIENT-SPECIFIC MODELS
Wong L et al., 2015
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REFERENCES
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