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Towards new measures of inflammation in spondyloarthritis
Turina, M.C.
Link to publication
Citation for published version (APA):Turina, M. C. (2016). Towards new measures of inflammation in spondyloarthritis.
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Download date: 18 Feb 2020
TOWARDS NEW MEASURES OF
INFLAMMATION IN SPONDYLOARTHRITIS
UITNODIGING
Voor het bijwonen van de openbare verdediging van
het proefschrift van
Maureen Turina
op vrijdag 1 april 2016 om 12:00 uur
in de AgnietenkapelOudezijds Voorburgwal
231,Amsterdam
Receptie ter plaatse na afloop van de promotie
Paranimfen
Jacky Paramarta: [email protected]
Talia Latuhihin: [email protected]
Towards new
measures of inflam
mation in spondyloarthritis M
aureen Cindy Turina
Towards new measures of inflammation in spondyloarthritis
Maureen Turina
TOWARDS NEW MEASURES OF
INFLAMMATION IN SPONDYLOARTHRITIS
Maureen Cindy Turina
ISBN: 978-94-6233-234-8Maureen Turina was supported by a fellowship of Janssen. Printing of this thesis was financially supported by ABBVIE B.V., AMC-UvA, the Dutch Arthritis Foundation (het Reumafonds), Janssen-Cilag B.V., Pfizer B.V., and UCB Pharma B.V., which is gratefully acknowledged.
Cover design and thesis layout: Midas Mentink (www.thesisexpert.nl) Printing: Gildeprint – Enschede (www.gildeprint.nl) Copyright © 2015 by M.C. Turina
All rights reserved. No part of this book may be reproduced, stored in a retrieval system, or transmitted in anyform or by any means, without permission of the author.
TOWARDS NEW MEASURES OF
INFLAMMATION IN SPONDYLOARTHRITIS
ACADEMISCH PROEFSCHRIFT
ter verkrijging van de graad van doctor
aan de Universiteit van Amsterdam
op gezag van de Rector Magnificus
prof. dr. D.C. van den Boom
ten overstaan van een door het College voor Promoties ingestelde commissie,
in het openbaar te verdedigen in de Agnietenkapel
op vrijdag 1 april 2016, te 12:00 uur
door Maureen Cindy Turina
geboren te Rotterdam
PROMOTIECOMMISSIE:
Promotores: Prof. dr. D.L.P. Baeten Universiteit van AmsterdamProf. dr. R.B.M. Landewé Universiteit van Amsterdam
Overige leden: Prof. dr. D. van Schaardenburg Universiteit van AmsterdamProf. dr. P.I. Spuls Universiteit van AmsterdamProf. dr. G.R.A.M. D’Haens Universiteit van AmsterdamProf. dr. P.L.C.M. van Riel Radboud Universiteit NijmegenDr. F.A. van Gaalen Universiteit Leiden
Faculteit der Geneeskunde
TABLE OF CONTENTS
Chapter 1 General introduction 9
Chapter 2 Serum biomarkers in spondyloarthritis-related diseases: lessons from psoriasis and inflammatory bowel diseases
19
Chapter 3 Serum inflammatory biomarkers fail to identify early axial spondyloartritis: results from the SpondyloArthritis Caught Early (SPACE)-cohort
43
Chapter 4 Clinical and imaging signs of spondyloarthritis in first-degree relatives of HLA-B27 positive ankylosing spondylitis patients: the pre-spondyloarthritis (Pre-SpA) cohort
55
Chapter 5 Calprotectin (S100A8/9) as serum biomarker for clinical response in proof-of-concept trials in axial and peripheral spondyloarthritis
75
Chapter 6 A psychometric analysis of outcome measures in peripheral spondyloarthritis
91
Chapter 7 Calprotectin serum level is an independent marker for radiographic spinal progression in axial spondyloarthritis
107
Chapter 8 General discussion and summary 113
Appendices Nederlandse samenvatting 135Dankwoord 143PhD portfolio 147Curriculum vitae 151List of publications 153