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The endothelial surface layer: a new target of research in kidney failure and peritonealdialysis

Vlahu, C.A.

Link to publication

Citation for published version (APA):Vlahu, C. A. (2016). The endothelial surface layer: a new target of research in kidney failure and peritonealdialysis.

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Download date: 01 Jul 2019

List of abbreviations List of authors and affiliations PhD Portofolio List of publications

About the author Acknowledgements

Appendices

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Appendices

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List of abbreviations

List of abbreviationsList of abbreviations

AGE ALAT APP BMI BP BV BVPD CA125 CRP CS CKD CKDD CKDP CVD DAPI DM DPerf D/P ratio Cr EBVD EDRD EG eGFR ELAR ELISA eNOS ESL FWT GAG HA HbA1c HD HDL HI Hyal HMWHA HS HSPGs IL-6 LDL LMWHA LVPD MC MDA MTAC MW NKF NUF NUFR PBR

Advanced glycation end-products Alanine aminotransferase Aminopeptidase P Body mass index Blood pressure Blood vessel Blood vessel profile density Cancer antigen 125 C-reactive protein Chondroitin sulfate Chronic kidney disease Chronic kidney disease exposed to Dianeal Chronic kidney disease exposed to Physioneal Cardiovascular disease 4',6-diamidino-2-phenylindole Diabetes mellitus Perfused diameter Dialysate-to-Plasma ratio of creatinine Estimated blood vessel density End-stage renal disease Endothelial glycocalyx Estimated glomerular filtration rate Estimated lymphatic absorption rate Enzyme-linked immunosorbent assay Endothelial nitric oxide synthase Endothelial surface layer Free water transport Glycosaminoglycans Hyaluronic acid Glycated hemoglobin Hemodialysis High-density lipoprotein Healthy individuals Hyaluronidase High molecular weight hyaluronan Heparan sulfate Heparan sulfate proteoglycan Interleukin-6 Low-density lipoprotein Low molecular weight HA Lymph vessel profile density Mesothelial cells Malondialdehyde Mass transfer area coefficient Molecular weight Normal kidney function Net ultrafiltration Net ultrafiltration rate Perfused boundary region

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Appendices

PD PDF PG PSR RBC RBCW ROS RRF RRT RTR SDC-1 SDF SPA SPARa SURS TC TCUFR TNF-α VBM VEGF VMD UFF

Peritoneal dialysis Peritoneal dialysis fluids Proteoglycans Picro-sirius red Red blood cell Red blood cell column width Reactive oxygen species Residual renal function Renal replacement therapy Renal transplant recipients Syndecan-1 Sidestream Darkfield Standard peritoneal permeability analysis Standard peritoneal permeability analysis adapted for rats Systematic uniform random sampling Total cholesterol Transcapillary ultrafiltration rate Tumor necrosis factor alfa Vascular basement membrane Vascular endothelial growth factor Valid microvascular density Ultrafiltration failure

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List of authors and affiliations

Authors and affiliationsJan Aten, PhDDepartment of PathologyAcademic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Frederike J. Bemelman, MD, PhDRenal Transplant Unit, Department of Nephrology, Division of Internal MedicineAcademic Medical Center, University of Amsterdam, Amsterdam,The Netherlands

Ineke J.M. ten Berge, MD, PhDRenal Transplant Unit, Department of Nephrology, Division of Internal MedicineAcademic Medical Center, University of Amsterdam, Amsterdam,The Netherlands

Vincent Everts, PhDVan Leeuwenhoek Center for Advanced Microscopy, Department of Cell Biology and Histology Academic Medical Center, Amsterdam, The NetherlandsDepartment of Oral Cell Biology, Academic Center for Dentistry Amsterdam, Univer-sity of Amsterdam and VU University Amsterdam, The Netherlands

Marijke de Graaff, MScDivision of Nephrology, Department of MedicineAcademic Medical Center, Amsterdam, The Netherlands

Marion G. Koopman, MDDepartment of Nephrology, Division of Internal MedicineAcademic Medical Center, University of Amsterdam, Amsterdam,The Netherlands

Raymond T. Krediet, MD, PhDDepartment of Nephrology, Division of Internal MedicineAcademic Medical Center, University of Amsterdam, Amsterdam,The Netherlands

Bregtje A. Lemkes, MD, PhDDepartment of Vascular MedicineAcademic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Deirisa Lopes Barreto, PhDDivision of Nephrology, Department of Medicine Academic Medical Center, Amsterdam, The Netherlands

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Appendices

Ties A. Mulders, MD, PhDDepartment of Vascular MedicineAcademic Medical Center, University of Amsterdam, Amsterdam,The Netherlands

Karlijn A.M.I. van der Pant, MDRenal Transplant Unit, Department of Nephrology, Division of Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam,The Netherlands

Dirk G. Struijk, MD, PhDDepartment of Nephrology, Division of Internal Medicine, Academic Medical Center, University of Amsterdam, The NetherlandsDianet Foundation, Amsterdam-Utrecht, The Netherlands

Geertrude H. Struijk, MDRenal Transplant Unit, Department of Nephrology, Division of Internal MedicineAcademic Medical Center, University of Amsterdam, Amsterdam,The Netherlands

Anne van Tellingen, MD, PhDZaans Medical Center, Zaandam, The Netherlands

Henk A. van VeenVan Leeuwenhoek Center for Advanced Microscopy, Department of Cell Biology and Histology Academic Medical Center, Amsterdam, The Netherlands

Hans Vink, PhDDepartment of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands

Dirk R. de Waart, PhDTygat Institute for Liver and Intestinal ResearchAmsterdam, The Netherlands

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PhD Portofolio

PhD portofolioName Carmen Anca VlahuStart PhD Program January 2010Title Thesis The endothelial surface layer: a new target of research in kidney failure and

peritoneal dialysisPromotor Prof. Dr. R.T. KredietCo-promotor Dr. D.G. StruijkDefence of the thesis May 17th 2016

General courses Year ECTS BROK: Legislation and Organization for Clinical Researchers (hercertificering) 2015 0.1Winterschool Nephrology 2011 1.3BROK: Legislation and Organization for Clinical Researchers 2011 0.9Scientific writing in English for publication 2010 0.5The AMC World of Science 2010 0.7Crash Course 2010 0.4

Specific courses Year ECTS ERA-EDTA Course on Dialysis Adequacy and Kinetic Modelling 2012 0.7Laboratory Animal Science, Artikel 9 2010 1.6Reference Manager Advanced Course 2010 0.1Reference Manager 2010 0.1PubMed Course 2010 0.1Clinical Epidemiology 2010 2.0

Lectures, Symposia, Workshops Year ECTS‘New kids on the block’, wetenschappelijk onderzoek in Nefrologie 2014 0.2PLAN day (Platform AIO’s Nefrologie) 2014 0.2Regional meeting Nephropathology 2014 0.1Successful conferencing 2010 0.2PLAN day (Platform AIO’s Nefrologie) 2010 0.2

Oral presentations Year ECTS Endothelial glycocalyx: a new target of research in PD and uremia related cardiovascular disease? 52nd ERA-EDTA Congress 2015 0.5Effects of chronic kidney failure and exposure to different dialysis solutions on the peritoneal membrane. 35th Annual Dialysis Conference 2015 0.5Lymphangiogenesis and lymphatic absorption are related and increased in chronic kidney failure, independent of dialysis solutions. 35th Annual Dialysis Conference 2015 0.5Syndecan-1 in the peritoneal microvasculature. Peritoneal Transport Meeting 2015 0.5The use of a biocompatible dialysis solution induces less damage to the peritoneal membrane in uremic rats. 15th Congress of the International Society for Peritoneal Dialysis 2014 0.5Is the systemic microvascular endothelial glycocalyx in peritoneal dialysis patients related to peritoneal transport? 15th Congress of the International Society for Peritoneal Dialysis 2014 0.5The state of the systemic microvascular endothelial glycocalyx influences peritoneal solute transport in peritoneal dialysis. 34th Annual Dialysis Conference 2014 0.5The peritoneal endothelial glycocalyx in uremic rats – the effect of dialysis solutions and relationships with peritoneal transport. 34th Annual Dialysis Conference 2014 0.5The peritoneal endothelial glycocalyx in rats with chronic kidney failure - the effect of dialysis solutions. Peritoneal Transport Meeting 2014 0.5The use of a biocompatible dialysis solution induces less damage to the peritoneal membrane in uremic rats. PLAN dag 2014 0.5The peritoneal endothelial glycocalyx during peritoneal dialysis. Personalized Dialysis Initiatives 2013 0.5The role of the endothelial glycocalyx in peritoneal transport. Peritoneal Transport Meeting 2013 0.5The endothelial glycocalyx and Na+ and fluid overload in hemodialysis patients. 50th ERA-EDTA Congress 2013 0.5

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Appendices

Studies on the microvascular glycocalyx. Peritoneal Transport Meeting 2012 0.5Damage of endothelial glycocalyx in dialysis patients. 31st Annual Dialysis Conference 2011 0.5The endothelial glycocalyx in end-stage renal disease. PLAN dag 2010 0.5A damaged glycocalyx in peritoneal dialysis patients. 30th Annual Dialysis Conference 2010 0.5

Poster presentations Year ECTS17th International Conference on Dialysis, Advances in kidney disease - New Orleans, USA 2015 0.552nd ERA-EDTA Congress – London, UK 2015 0.5ASN Kidney Week – Philadelphia, USA 2014 1.051st ERA-EDTA Congress - Amsterdam, The Netherlands 2014 0.515th Congress of the International Society for Peritoneal Dialysis – Madrid, Spain 2014 1.0Dutch Nephrology Days - Veldhoven, The Netherlands 2014 0.5ISN World Congress of Nephrology – Hong Kong 2013 0.5European Peritoneal Dialysis Meeting (EuroPD) – Maastricht, The Netherlands 2013 0.5ASN Kidney Week – Atlanta, USA 2013 1.014th Congress of the International Society for Peritoneal Dialysis – Kuala Lumpur, Malaysia 2012 0.510th European Peritoneal Dialysis Meeting – Birminghan, UK 2011 0.5ISN World Congress of Nephrology – Vancouver, Canada 2011 0.5ASN Kidney Week – Denver, USA 2010 0.5

(Inter)national conferences Year ECTS52nd ERA-EDTA Congress - London, UK 2015 1.035th Annual Dialysis Conference - New Orleans, USA 2015 1.017th International Conference on Dialysis, Advances in kidney disease - New Orleans, USA 2015 0.75Peritoneal Transport Meeting - Warsaw, Poland 2015 0.2515th Congress of the International Society for Peritoneal Dialysis – Madrid, Spain 2014 1.0Peritoneal Transport Meeting – Amsterdam, The Netherlands 2014 0.2534th Annual Dialysis Conference - Atlanta, USA 2014 1.051st ERA-EDTA Congress - Amsterdam, The Netherlands 2014 1.0Dutch Nephrology Days - Veldhoven, The Netherlands 2014 0.7550th ERA-EDTA Congress -Istanbul, Turkey 2013 1.0ISN World Congress of Nephrology – Hong Kong 2013 1.0Peritoneal Transport Meeting - Maastricht, The Netherlands 2013 0.25Personalized Dialysis Initiatives – De Lutte, The Netherlands 2013 0.25Peritoneal Transport Meeting - Warsaw, Poland 2012 0.2514th Congress of the International Society for Peritoneal Dialysis – Kuala Lumpur, Malaysia 2012 1.031st Annual Dialysis Conference - Phoenix, USA 2011 1.0Dutch Nephrology Days - Veldhoven, The Netherlands 2011 0.7530th Annual Dialysis Conference - Seattle, USA 2010 1.0ASN Renal Week – Denver, USA 2010 1.0Dutch Nephrology Days - Veldhoven, The Netherlands 2010 0.75

Teaching Year ECTSOptional course on Kidney failure: organization, student supervision, teaching 2011 2.0Optional course on Kidney failure: organization, student supervision, teaching 2010 2.0

Reviewer for scientific journals Nephrology Dialysis TransplantationAtherosclerosisPeritoneal Dialysis InternationalInternational Urology and Nephrology

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PhD Portofolio

Awards and Prizes YearBest Peritoneal Dialysis Abstract: The State of the Systemic Microvascular Endothelial Glycocalyx Influences Peritoneal Transport in Peritoneal Dialysis Patients. 34th Annual Dialysis Conference 2014Best abstracts presented by young authors: The use of a biocompatible dialysis solution induces less damage to the peritoneal membrane in uremic rats. 51st ERA-EDTA Congress

2014

Best abstracts presented by young authors: The endothelial glycocalyx and Na+ and fluid overload in hemodialysis patients. 50th ERA-EDTA Congress 2013

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Appendices

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List of publications

List of publicationsVlahu CA, Aten J, de Graaff M, van Veen H, Everts V, de Waart DR, Struijk DG,

Krediet RT. New insights in effects of dialysate exposure on the peritoneum in chronic kidney failure. Perit Dial Int in press.

Vlahu CA, Krediet RT. Can plasma hyaluronan and hyaluronidase be used as markers of the endothelial glyco-calyx in patients with kidney disease? Adv Perit Dial 2015;31:3-6.

Vlahu CA, de Graaff M, Aten J, Struijk DG, Krediet RT. Lymphangiogenesis and lymphatic absorption are related and increased in chronic kidney failure, independent of exposure to dialysis solutions. Adv Perit Dial 2015;31:21-5.

Vlahu CA, Lopes Barreto D, Struijk DG, Vink H, Krediet RT. Is the systemic microvascular endothelial glycocalyx in peritoneal dialysis patients related to peritoneal transport? Nephron Clin Pract. 2014;128(1-2):159-65.

Vlahu CA, Lemkes BA, Struijk DG, Koopman MG, Krediet RT, Vink H. Damage of the endothelial glycocalyx in dialysis patients. J Am Soc Nephrol. 2012 Nov;23(11):1900-8.

Balafa O, Vlahu CA, Sampimon D, Coester AM, Struijk DG, Krediet RT. Lack of correlation between baseline peritoneal membrane status and pre-dialytic char-acteristics. Adv Perit Dial. 2010;26:16-20.

Balafa O, Vlahu CA, Coester AM, Struijk DG, Krediet RT. Predialytic period and baseline peritoneal membrane status: any connection? Perit Dial Int. 2010 May-Jun;30(3):380-1.