utilizing nessi™ for analytical applications dave veltkamp, cpac new sampling/sensor initiative...
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Utilizing NeSSI™ for Utilizing NeSSI™ for Analytical ApplicationsAnalytical Applications
Dave Veltkamp, CPACDave Veltkamp, CPAC
NeNew w SSampling/ampling/SSensor ensor IInitiative (nitiative (NeSSINeSSI™)™)
Overview of TalkOverview of TalkDescribe the features of NeSSI™ most Describe the features of NeSSI™ most likely to impact lab applicationslikely to impact lab applications
Discuss how NeSSI™ can facilitate Discuss how NeSSI™ can facilitate laboratory applications and how laboratory applications and how current development fits lab needscurrent development fits lab needs
Outline some outside proposals Outline some outside proposals recently written to help fund NeSSI™ recently written to help fund NeSSI™ development & demonstration development & demonstration
Mention some web-based resources at Mention some web-based resources at CPACCPAC
What does NeSSI™ ProvideWhat does NeSSI™ ProvideSimple “Lego-like” assemblySimple “Lego-like” assembly
Easy to re-configureEasy to re-configureNo special tools or skills requiredNo special tools or skills required
Standardized flow componentsStandardized flow components““Mix-and-match” compatibility between vendorsMix-and-match” compatibility between vendorsGrowing list of componentsGrowing list of components
Standardized electrical and communication (soon)Standardized electrical and communication (soon)““Plug-and-play” integration of multiple devicesPlug-and-play” integration of multiple devicesSimplified interface for programmatic I/O and controlSimplified interface for programmatic I/O and control
Advanced analytics and measurement Advanced analytics and measurement environmentenvironment
Mini or Micro-analyzersMini or Micro-analyzersIntegrated analysis or “smart” systemsIntegrated analysis or “smart” systems
Expose students to “Industrial” techniques & Expose students to “Industrial” techniques & needsneeds
NeSSI™: Enabler for NeSSI™: Enabler for MicroAnalytical MicroAnalytical
(the “rail” concept)(the “rail” concept)
Standard Mechanical Interface “Rail”
Standard Electrical (Digital) Interface “Rail”
Anyone’s Sensor Anyone’s Actuator
SAM*
Standard “hockey-puck
PC”P
V
*Sensor/Actuator Manager
Standard“connectivity
”
How Does NeSSI™ Fit in the How Does NeSSI™ Fit in the LabLab
Instrument/Sensor InterfacesInstrument/Sensor InterfacesDesign standards make development simplerDesign standards make development simpler
Reduced toolset to be masteredReduced toolset to be mastered Reduced sample variability to account forReduced sample variability to account for
Calibration/validation built-inCalibration/validation built-in Consistent physical environment for measurementConsistent physical environment for measurement Stream switching and/or mixing allow generation of Stream switching and/or mixing allow generation of
standards to match analytical requirementsstandards to match analytical requirements
Reaction monitoringReaction monitoringMicroreactors and continuous flow reactorsMicroreactors and continuous flow reactorsBatch reactors (with fast loop)Batch reactors (with fast loop)
Sample PreparationSample PreparationGas handling (mixing, generation, delivery)Gas handling (mixing, generation, delivery)Liquid handling (mixing, dilution, conditioning, etc.)Liquid handling (mixing, dilution, conditioning, etc.)
Special Lab NeSSI™ Special Lab NeSSI™ RequirementsRequirements
Flowing streamsFlowing streamsNeed to move liquid and gas streams through Need to move liquid and gas streams through NeSSI™ NeSSI™ Most laboratory analysis involves discrete samples Most laboratory analysis involves discrete samples rather than sample streamsrather than sample streamsAnalytical characterization of flow in NeSSI™ Analytical characterization of flow in NeSSI™ neededneeded
Heating and CoolingHeating and CoolingLaboratory applications need bothLaboratory applications need bothMay require more rapid thermal responseMay require more rapid thermal response
Integration with other lab apparatusIntegration with other lab apparatusSerial communication most commonSerial communication most commonIntegration with lab software systemsIntegration with lab software systems
Low costLow costCompeting with other solutions that don’t carry Competing with other solutions that don’t carry some of NeSSI’s more exotic featuressome of NeSSI’s more exotic features
Recent proposals featuring Recent proposals featuring NeSSI™ NeSSI™
NSF Instrumentation for Materials NSF Instrumentation for Materials Research (IMR)Research (IMR)
Involves NeSSI™ and Microreactors to Involves NeSSI™ and Microreactors to elucidate reaction kinetics and mechanisms elucidate reaction kinetics and mechanisms for polymer modification chemistryfor polymer modification chemistry
Builds on previous CPAC concepts for Builds on previous CPAC concepts for NeSSI™ as fluidic delivery AND analysis NeSSI™ as fluidic delivery AND analysis platform for microreactorsplatform for microreactors
Includes development and testing of Includes development and testing of Synovec’s μ-MMS in NeSSI™ Synovec’s μ-MMS in NeSSI™
3 years, $718K 3 years, $718K
NeSSI™ Proposals (cont.)NeSSI™ Proposals (cont.)
NSF Chemistry Research NSF Chemistry Research Instrumentation and Facilities: Instrumentation and Facilities: Instrument Development (CRIF-ID)Instrument Development (CRIF-ID)
Provides basic research and testing to Provides basic research and testing to characterize NeSSI™ flows and develop characterize NeSSI™ flows and develop needed support sub-systems for utilizing needed support sub-systems for utilizing NeSSI™ in laboratory applicationsNeSSI™ in laboratory applications
Funding to develop 3 (gas, liquid, and Funding to develop 3 (gas, liquid, and student lab) demonstration NeSSI™ student lab) demonstration NeSSI™ systemssystems
3 years, $642K3 years, $642K
NeSSI™ Proposals (cont.)NeSSI™ Proposals (cont.)
NSF Sensors and Sensor NetworksNSF Sensors and Sensor NetworksInvolves using NeSSI™ as a platform for Involves using NeSSI™ as a platform for characterizing vapochromatic compounds characterizing vapochromatic compounds and development of gas phase sensorsand development of gas phase sensors2 identical NeSSI™ systems at UW and UM2 identical NeSSI™ systems at UW and UM3 years, $612K3 years, $612K
Washington Technology Center (WTC)Washington Technology Center (WTC)Development of prototype sensor/actuator Development of prototype sensor/actuator manager (SAM)manager (SAM)Collaborative effort with InfometrixCollaborative effort with InfometrixPhase I, 6 months, $40KPhase I, 6 months, $40K
NeSSI™ Fermentation NeSSI™ Fermentation SystemSystem
Switching filter system to handle Switching filter system to handle particulate laden liquid streamsparticulate laden liquid streams
Cells in fermentation brothCells in fermentation broth
Supplied by Bob Sherman, CircorSupplied by Bob Sherman, Circor
Interested in plugging, cleaning, and Interested in plugging, cleaning, and other issues related to bio/pharma other issues related to bio/pharma applicationsapplications
2 Filters
Building Automated NeSSI™ Building Automated NeSSI™ Swagelok provided 5 pneumatic valves, Swagelok provided 5 pneumatic valves, flow components and pressure flow components and pressure transducerstransducersParker providing solenoid pilot valve Parker providing solenoid pilot valve manifold for actuating pneumatic valvesmanifold for actuating pneumatic valvesBrooks (Emerson) provided MFC’s and Brooks (Emerson) provided MFC’s and electronicselectronicsHoneywell providing funds for data I/O Honeywell providing funds for data I/O and control systemand control systemThanks to all these contributions, we are Thanks to all these contributions, we are very close to having an automated very close to having an automated NeSSI™ systemNeSSI™ system
NeSSINeSSI™™ Knowledge Network Knowledge Network
Main topic page divided into Main topic page divided into 4 sections4 sections
News and InformationNews and Information
Discussion (NeSSI Q&A)Discussion (NeSSI Q&A)
Component ListComponent List Only Manufacturers group may Only Manufacturers group may
post herepost here
Testing and ExamplesTesting and Examples
Main NeSSI™ web siteMain NeSSI™ web sitehttp://http://www.cpac.washington.edu/NeSSI.htmwww.cpac.washington.edu/NeSSI.htm
NKN can be found atNKN can be found athttp://http://www.cpac.washington.edu/NeSSI/NKN.htmlwww.cpac.washington.edu/NeSSI/NKN.html
Component List Sub-Component List Sub-topicstopics
Page shown from the “Valve, Manual” Page shown from the “Valve, Manual” topictopic
Listing of topics under manual valve main Listing of topics under manual valve main topictopic
Number of posts will correspond to Number of posts will correspond to different available componentsdifferent available components
Component List PageComponent List PageExample post Example post from the from the component component list pagelist page
URL from URL from VendorVendorSpec. sheet Spec. sheet or linkor linkPicture, Picture, description, or description, or link to more link to more informationinformation
Other Vendors are Other Vendors are currently working to currently working to populate the list with populate the list with more componentsmore components
User Self-RegistrationUser Self-Registration
Allows users to setup accountsAllows users to setup accountsSelecting to join “Manufacturers” Selecting to join “Manufacturers” group will queue user’s group will queue user’s registration until a moderator registration until a moderator approves it.approves it.Membership in other groups Membership in other groups automatically approved automatically approved immediately immediately
Profile data will be used for Profile data will be used for NeSSI™ mailing listNeSSI™ mailing list
Check the options available from Check the options available from the “Edit Profile” link once user the “Edit Profile” link once user activates accountactivates account
Once user submits registration Once user submits registration form, they are sent an email with form, they are sent an email with instructions for activating their instructions for activating their new accountnew account
Your account is not active till you Your account is not active till you log in and follow the instructions log in and follow the instructions in the emailin the email
NKN ConclusionNKN Conclusion
New software and web site ready to be usedNew software and web site ready to be usedThanks to Michelle Cohn, UOP for helping CPAC Thanks to Michelle Cohn, UOP for helping CPAC buy a new server to host NeSSI™ and NKN web buy a new server to host NeSSI™ and NKN web sitessites
Site functions well on the new server – much Site functions well on the new server – much easier to use for both posting and browsingeasier to use for both posting and browsing
NeSSI Component List is becoming NeSSI Component List is becoming populatedpopulated
Major manufacturers (Parker, Circor, Swagelok) Major manufacturers (Parker, Circor, Swagelok) already signed up and starting to supply contentalready signed up and starting to supply content
Still need to get smaller suppliers to do the sameStill need to get smaller suppliers to do the same
Need to get user community to register and Need to get user community to register and start using itstart using it
NeSSI™ Sensor SurveyNeSSI™ Sensor Survey
The purpose of this survey is to gather The purpose of this survey is to gather information on the sensors and information on the sensors and actuators needed for NeSSI Sample actuators needed for NeSSI Sample Systems, Analytical Systems, and Systems, Analytical Systems, and Cluster Applications. Cluster Applications.
This data will be shared with sensor and This data will be shared with sensor and instrument vendors to help them prioritize instrument vendors to help them prioritize development of the devices needed across development of the devices needed across industries and applications. industries and applications. The more information you can provide, the The more information you can provide, the faster better products and performance faster better products and performance can be delivered can be delivered
NeSSI™ Sensor Survey NeSSI™ Sensor Survey (cont.)(cont.)
On-line survey form on the CPAC NeSSI™ On-line survey form on the CPAC NeSSI™ web siteweb site
http://www.cpac.washington.edu/NeSSI/CPAC_Nehttp://www.cpac.washington.edu/NeSSI/CPAC_NeSSI_Sensor_Survey.htmSSI_Sensor_Survey.htm
Questions about condition sensorsQuestions about condition sensorsAre you interestedAre you interestedHow would you rank their importanceHow would you rank their importanceOperating rangesOperating ranges
Questions about analytical sensorsQuestions about analytical sensorsAre you interestedAre you interestedHow would you rank their importanceHow would you rank their importanceOperating rangesOperating ranges
Questions about actuatorsQuestions about actuatorsQuestions about “Clusters”Questions about “Clusters”Optional contact informationOptional contact information
NeSSI™ Sensor Survey NeSSI™ Sensor Survey ResultsResults
Condition SensorsCondition Sensors
Analytical SensorsAnalytical Sensors
Count Mean Rank Median RankPressure 18 3.8 44Temp 18 3.7 3.5Flow 19 3.9 4Humidity 16 3.0 3Cond. 12 2.6 3Other 8 2.9 3Combined 16 3.5 3
O2 NOx pH H2 CO CO2 Raman NIRCount 17 10 14 14 12 11 11 14
Mean Rank 3.7 3.2 3.0 3.3 3.1 3.1 3.0 3.2Med Rank 4 3 3 3 3 3 3 3
MIR UV/Vis NMR MS GC LC ViscosityCount 14 13 6 10 16 5 11
Mean Rank 3.2 3.1 2.9 3.2 3.9 3.0 2.9Med Rank 3 3 3 3 4 3 3
NeSSI™ Sensor Survey NeSSI™ Sensor Survey ResultsResults
ActuatorsActuators
ClustersClusters
14 of the 21 respondents indicated they 14 of the 21 respondents indicated they would share information with Vendorswould share information with Vendors
Count Mean Rank Median RankOn/Off Valve 18 3.7 4 Ball 8 Diaphragm 6Modulator Valve 14 3.3 3Solenoid Valve 15 3.2 3MFC 16 3.6 3VFC 14 3.4 3
CountCEMS 13Clean Water 11Waste Water 9HRVOC 8
NeSSI™ Sensor Survey NeSSI™ Sensor Survey (cont.)(cont.)
Plan is to continue to solicit responses from Plan is to continue to solicit responses from usersusers
Additions to survey questions or content welcomeAdditions to survey questions or content welcomeMay expand survey activities to help provide May expand survey activities to help provide market directions to suppliersmarket directions to suppliers
Other aspects of NeSSI™ developmentOther aspects of NeSSI™ development Applet Software and other issues relate to SAMApplet Software and other issues relate to SAM New opportunities or innovationsNew opportunities or innovations
Need to reach beyond the normal NeSSI™ Need to reach beyond the normal NeSSI™ enthusiastsenthusiasts
Combined with the discussion board, surveys Combined with the discussion board, surveys provide a valuable resource for both end-users provide a valuable resource for both end-users and manufacturers of NeSSIand manufacturers of NeSSI
Summary & ConclusionSummary & Conclusion
Automated NeSSI™ ready for developmentAutomated NeSSI™ ready for developmentWorking spec/prototype design completeWorking spec/prototype design completePrototypes demonstrated in real applicationsPrototypes demonstrated in real applicationsResolution of the NeSSI™ bus issueResolution of the NeSSI™ bus issue
For some laboratory applicationsFor some laboratory applicationsComponents and systems currently available Components and systems currently available will immediately work and provide benefitswill immediately work and provide benefits
For other applicationsFor other applicationsNew components/architecture will be needed New components/architecture will be needed to “fit” current lab practicesto “fit” current lab practices
The future holds a lot of promise!!The future holds a lot of promise!!