using realtime fmri based neurofeedback to probe default network regulation
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Using RealTimefMRI Based Neurofeedback To Probe Default Network Regulation
R. Cameron Craddock, PhDDirector of Imaging, Child Mind InstituteResearch Scientist, Nathan Kline Institute
February 25, 2016
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Default Network
Task based deactivationBuckner et al. Ann. N.Y. Acad. Sci. 1124: 1-38 (2008).
Default Network Connectivity
Greicius et. al. 2007 Biol. Psychiatry
DN Dysregulation
Sheline et. al. 2009 PNAS
ICN Competition
Fox MD PNAS 2005
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RT Neurofeedback of DMNTest hypothesis of DMN dysregulation in depression, ADHD, aging, etc
Exp. Design
Class Training Labels
Training run
Time-LabeledScans
Image Recon and SVM Classification
Image Data
Data AcquisitionStimulus Presentation
StimulusConventional FMRI
Test Data Classifier OutputTesting Run
Real-Time Tracking RSNsLaConte, et al. (2007) Hum Brain Mapp. 28: 1033-1044Stephen LaConte August 19, 2009
Stimulus seen by volunteerUpdated fMRI resultsMotion tracking and correctionIntensity (brightness) of a single voxel, changing during stimulus conditionsController interface for display parameters
Decoding DN Activity
DMN Modulation Task
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Modulating the DMN
Results
Accuracy was measured from Pearsons correlation between task paradigm and DMN activity extracted after post-processing.
Behavioral Correlates
Measures that were significantly associated with DN regulation include (p 10,000 datasets6,422 individuals4 90 years old539 ASD383 ADHD72 Schizophrenia29 Cocaine Dependent6 Epilepsy
http://fcon_1000.projects.nitrc.org/
Sharing preprocessed dataMake data available to a wider audience of researchersEvaluate reproducibility of analysis results
http://preprocessed-connectomes-project.github.io/
Software to enable a new scale of data analysisVery large datasetsNeed to harness high-performance computing to expedite processingRS fMRI preprocessing is a moving targetMany new methods are proposed all the timeNeed to compare outputs from different processing strategiesMany different toolsets have different strengthsNeed to be able to combine tools from different packages
http://fcp-indi.github.io/
Principles of Open NeuroscienceData, tools and ideas should be openly shared-The Neuro Bureau Manifesto
http://www.neurobureau.org
AcknowledgmentsChild Mind InstituteMichael Milham, MD, PhDZarrar Shehzad
Nathan Kline InstituteAmalia McDonaldStan Colcombe, PhDBennett Leventhal, MD
NYU Child Study CenterAdriana DiMartino, MDF. Xavier Castellanos, MDVTCRIStephen LaConte, PhDPearl Chiu, PhDJonathan Lisinski, MS
Emory UniversityHelen Mayberg, MDThis work is funded by: A NARSAD Young Investigator Award and NIMH R01MH101555