uronic acid pathway
DESCRIPTION
For study purpose only.TRANSCRIPT
![Page 1: Uronic acid pathway](https://reader035.vdocuments.us/reader035/viewer/2022062418/5562f789d8b42a213b8b552d/html5/thumbnails/1.jpg)
![Page 2: Uronic acid pathway](https://reader035.vdocuments.us/reader035/viewer/2022062418/5562f789d8b42a213b8b552d/html5/thumbnails/2.jpg)
URONIC ACID PATHWAY
![Page 3: Uronic acid pathway](https://reader035.vdocuments.us/reader035/viewer/2022062418/5562f789d8b42a213b8b552d/html5/thumbnails/3.jpg)
CONTENTS
DEFINITION OCCURRENCE & TISSUE
DISTRIBUTION BIOMEDICAL IMPORTANCE METABOLIC STEPS REGULATION CLINICAL IMPORTANCE REFERENCES ACKNOWLEDGEMENTS
![Page 4: Uronic acid pathway](https://reader035.vdocuments.us/reader035/viewer/2022062418/5562f789d8b42a213b8b552d/html5/thumbnails/4.jpg)
DEFINITION
IT IS AN ALTERNATIVE PATHWAY FOR
OXIDATION OF GLUCOSE.
![Page 5: Uronic acid pathway](https://reader035.vdocuments.us/reader035/viewer/2022062418/5562f789d8b42a213b8b552d/html5/thumbnails/5.jpg)
OCCURENCE
IN CYTOPLASM
![Page 6: Uronic acid pathway](https://reader035.vdocuments.us/reader035/viewer/2022062418/5562f789d8b42a213b8b552d/html5/thumbnails/6.jpg)
TISSUE DISTRIBUTION
LIVERADIPOSE TISSUE
![Page 7: Uronic acid pathway](https://reader035.vdocuments.us/reader035/viewer/2022062418/5562f789d8b42a213b8b552d/html5/thumbnails/7.jpg)
BIOMEDICAL IMPORTANCE
Major Function is to produce D-Glucuronic acid which is required for:
Detoxification of foreign chemicals.
Synthesis of MPS.There is no energy production.
![Page 8: Uronic acid pathway](https://reader035.vdocuments.us/reader035/viewer/2022062418/5562f789d8b42a213b8b552d/html5/thumbnails/8.jpg)
METABOLIC STEPS
GLUCOSE Glucokinase ATP ADP
Glucose 6-
phospatePhosphogluco-Mutase Glucose 1-
phosphate
![Page 9: Uronic acid pathway](https://reader035.vdocuments.us/reader035/viewer/2022062418/5562f789d8b42a213b8b552d/html5/thumbnails/9.jpg)
CONTINUED:
UDP-Glu-pyrophos- UTP PPi
Phorylase UDP-GlucoseUDP-Glu- 2NAD+ 2NADH
+ H+ dehydrogenase UDP-Glucoronate
phosphorylation D-Glucuronic acid 1-P
![Page 10: Uronic acid pathway](https://reader035.vdocuments.us/reader035/viewer/2022062418/5562f789d8b42a213b8b552d/html5/thumbnails/10.jpg)
CONTINUED:
Glucuronidase H2O UDP
D-Glucoronic acid LGDH L-Gulonic acid
![Page 11: Uronic acid pathway](https://reader035.vdocuments.us/reader035/viewer/2022062418/5562f789d8b42a213b8b552d/html5/thumbnails/11.jpg)
CONTINUED:
L-Gulonic acid beta-HD L-
Gulonolactone
oxidase3-Ketogulonic L-
Ascorbic acidAcid beta-keto L-gulonate
decarboxylase L-Xylulose
![Page 12: Uronic acid pathway](https://reader035.vdocuments.us/reader035/viewer/2022062418/5562f789d8b42a213b8b552d/html5/thumbnails/12.jpg)
CONTINUED:
Xylulose reductase Xylitol NAD+
NADH + H+
D-Xylulose Xylulose kinase ATP ADP Xylulose 5-phosphate
HMP Shunt
![Page 13: Uronic acid pathway](https://reader035.vdocuments.us/reader035/viewer/2022062418/5562f789d8b42a213b8b552d/html5/thumbnails/13.jpg)
REGULATION
Administration of drugs i.e Chlorobutanol &
Barbital significantly increases the uronic acid pathway.
Certain drugs are also found to enhance the synthesis of Ascorbic acid.
![Page 14: Uronic acid pathway](https://reader035.vdocuments.us/reader035/viewer/2022062418/5562f789d8b42a213b8b552d/html5/thumbnails/14.jpg)
CLINICAL IMPORTANCE
o ESSENTIAL PENTOSURIA: It is an Autosomal recessive
disorder.
Metabolic defect:-
Deficiency of Xylitol Reductase
![Page 15: Uronic acid pathway](https://reader035.vdocuments.us/reader035/viewer/2022062418/5562f789d8b42a213b8b552d/html5/thumbnails/15.jpg)
REFERENCES
BIOCHEMISTRY BY THOMAS. M.DEVLIN ,Edition no.7Pg.655 &656
HARPER’S ILLUSTRATED BIOCHEMISTRY EDITION NO.29,Pg.201 &202
MED. BIOCHEMISTRY BY MN.CHATTERJEA EDITION NO.8, Pg.362 & 363
BIOCHEMISTRY BY U.SATYANARAYANA EDITION NO.3, Pg.276
![Page 16: Uronic acid pathway](https://reader035.vdocuments.us/reader035/viewer/2022062418/5562f789d8b42a213b8b552d/html5/thumbnails/16.jpg)