Targeting Endoplasmic Reticulum for Combating Type 1 Diabetes

Fumihiko Urano, MD, PhD April 10, 2012

Understand

Identify

Treat

Three Step Formula

International Registry

UnderstandType 1 diabetes

Root cause ?

Understand T1D at the Molecular Level

Endoplasmic Reticulum Disease

Endoplasmic Reticulum ?

DNA becomes PROTEIN in the ER

Healthy Endoplasmic Reticulum

LIFE

Disruption of Healthy ERcauses beta cell death

How ?

Identify DRUGS that can maintain HEALTHY ER

Induced Pluripotent Stem Cells (iPS cells)

Skin fibroblasts iPS Cells

Beta Cells

Neurons

Understand

Identify

Treat

Three Step Formula

Karen SargentKohsuke Kanekura

Takashi HaraChristine Oslowski

Simin LuBryan O’Sullivan-Murphy

Victor Liu Mai KanekuraMariko Hara

Julie Zhu

URANO LABURANO LAB