update on indications for valvular heart disease intervention · j thorac cardiovasc surg...
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Update on Indications for Valvular
Heart Disease Intervention
Chris C. Cook, MD
Assistant Professor of Cardiac Surgery
University of Pittsburgh Medical Center
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Objectives
• Review changing indications
– Mitral regurgitation
– Ischemic MR
– Tricuspid regurgitation
• Minimally invasive cardiac surgery
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63 yo attorney, mild SOB during cardio
workout, nl LV, nl cors, Severe MR
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Repair: P2 resection, chordal transfer
from P2 to A2, 32mm ring
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Find MR, Fix MR : But why?
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• Preserved LV function
• No anti-coagulation
• Freedom from re-op
• Low early and late mortality
Mitral Valve Repair – 2015
“cure” mitral disease! 9
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Repair MR!
0
20
40
60
80
100
0 2 4 6 8 10
General Population
Replacement
Repair
p = 0.0004
Surv
ival (%
)
Time (Years)
68%
52%
Enriquez Sarano et al. Circulation 1995;91:1022
Cure MR!
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Bonow et al. Circulation 2006; 114 (5): e84-231.
ACC/AHA referral guidelines: 2006-2013
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Madaric et al. Am Heart J 2007;154:180
n =19
LVEF > 60%
NYHA class I
Severe MR without symptoms does not exist !
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J Thorac Cardiovasc Surg 2003;125:1143-1152
0
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0 1 2 3 4 5 6 7 8 9 10 11
Mitral Regurgitation Survival After Mitral Valve Surgery
100
80
60
40
20
0
Surv
ival (p
erc
ent)
0 2 4 6 8 10 14 12
Time (years)
David et al, J Thorac Cardiovasc Surg 2003;126:1143-1152
FC I-II
58%
FC III-IV
81%
n=488
p<0.001
Wait for CHF ?
symptoms ?
Bad !
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Wait until EF falls ? Normal EF – No MR
30 cc EDV
70 cc SV
70cc SV / 70cc SV + 30 cc EDV (70/100) = EF 70 % 15
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Normal EF – Severe MR
30 cc EDV
70 cc SV
70 cc RV
70cc SV +70cc RV/ 70cc SV + 7- cc RV+30 cc EDV (140/170) = EF 84 % 16
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Enriquez-Sarano et al. Circ 1994:90:830-837
Wait until EF falls – Bad !
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Enriquez-Sarano et al. Rev Card 2010
Wait until LV dilates – Bad !
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Bando et al. JTCVS 2005
Wait until A Fib – Bad !
Theirry et al. EJCVS 2006 19
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Wait until PAP rises – Bad !
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ACC/AHA guidelines: prior to 2014 Mitral valve repair, wait until:
Symptoms …. BAD
if “no” symptoms, wait until:
A Fib
Pulm HTN
Increase LV size
Fall in EF%
….also BAD ! 21
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Mitral Repair Guidelines
“Watchful Waiting” (by 2013 guidelines)
“takes years from patients lives,
these are guidelines to die by,
not to live by !”
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Overall 10 year survival –
50% med tx vs
86% - early repair
Montant - Annals of Thoracic Surgery, 2009
268 propensity matched assx pts- severe MR
Why are we waiting ?
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Durability of Mitral Valve Repair
Braunberger E. et.al. Circulation. 2001;104[suppl I]:I-8-I-11. 24
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ACC/AHA guidelines: 2013
Early mitral valve surgery –
Indications include:
“if repair possible…
if experienced repair centers…
if experienced repair surgeons…
if high likelihood of repair”…
…Iffy and Unpredictable ? 25
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Have we even been
following the 2013
guidelines ? …even though they are lame !!
Why are we waiting ?
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Toledano et al. Can J Cardiol 2007; 23 (3): 209-14
NO ! ……. 2-30%
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33% mortality @ 1 yr Failure of Guideline Adherence for Intervention in Patients With Severe Mitral Regurgitation
David S. Bach, et al JACC Vol. 54, No. 9, 2009
USA Mitral referral rate – 50% !
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25% of moderate MR patients
dropped LV function…
without ever being
detected as severe !!
Suri – EACTS Sept, 2010 , Mayo
Why are we waiting ?
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LA size
mod MR severe MR
Impact of Left Atrial Volume on Clinical Outcome in Organic Mitral Regurgitation
• Tourneau et al, JACC 2012
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Exercise Testing
Prognostic Value of Exercise Testing in Organic Mitral Regurgitation
•EHJ 2012
With exercise : any Increased MR,
AF , PHTN or Drop in LV status
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Mitral Repair Guidelines - 2014
Any Sx or AF or PHTN !
Earlier Surgery :
EF < 65%
ESD > 35 mm
Any Flail
LA size
Moderate MR
Exercise Testing
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ISCHEMIC MR
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Trade off?
• Which is more important to long-term
survival?
• Operative Mortality vs. MR Recurrence
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Primary Endpoint • Degree of LV reverse remodeling
– Assessed by LV end systolic volume index
by TTE at 12 months postop
• Powered (90%) to detect an
improvement of 15mL/m2 from repair to
replacement in LVESVI
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Median change in LVESVI Median with 95% CI for change in LVESVI from baseline to 1yr
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Recurrent MR @ 1 year Moderate or severe recurrent MR
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Mortality
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Further Subgroup Analysis
• If you had a repair and you did not
recur, the survival was better than if you
repaired and recurred or replaced
• How do you predict this?
• Who made up the subgroup that most
often recurred?
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Basal Aneurysm
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Tricuspid Valve
“the forgotten valve”
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Is TR important?
When/how to fix TR
What lessons have we learned?
OK, if we find MR, we will fix MR !
But repair TR, or ignore it ?
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Clinical Presentation of TR
Decreased CO
Fatigue, decreased exercise tolerance
“Right-sided” Heart Failure
Ascites, edema, decreased appetite, abdominal fullness
...Patients feel terrible
Valve repair for functional tricuspid valve regurgitation:
anatomical and surgical considerations
Rogers JH, Bolling SF Semin Thorac Cardiovasc Surg. 2010 ;22(1):84-9 45
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…and they die! TR Increases Mortality !
Nath. JACC 2004;43:405.
5223 subjects : Mod-Sev TR increased mortality
independent of PASP, LVEF, IVC size, RV size/ function.
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TR is Currently Ignored !!
STS Database 2009
MR + TR
Annual New MR
Annual MR Surgeries
Annual TR Surgeries
4,000,000
250,000
50,000
5,500
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TR Lessons : Look for it pre-op !!
Frater (JTCVS 122:2001)
Functional TR – dynamic and responds
to anesthesia…
“4+ TR, as the patient enters the OR
- can become mild”
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TR does not go away by itself !! 5589 MVr only cases (McCarthy, ATS 2004)
Preop 16% had 3/4+ TR
Discharge ( MVR without TVr)
9%, or > ½ still had 3/4+ TR
FU - 62% had residual severe TR !!!…
TR does not just go away ! 50
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Anatomy of Functional TR
Annular, RA, RV and LV geometry changes of TR Carpentier. JTCVS 1974;67:53.
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TR – do it now, not later !!
Bernal (JTCVS 130:2005)
Patients left with post-op TR, when returned for redo TVr
30 day mortality was 35%!
Highest op mortality in STS!!
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Ignore TR at the patients peril !
Trans-Apical 4 Chamber View
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TR Lessons - Tricuspid Anatomy
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TV ring risks
AV Node injury
Dehiscence
Hemolysis
Endocarditis
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Don’t ignore TR :
Repair Lessons for Functional TR
Annuloplasty Rings DeVega
DeVega. Rev Esp Cardiol 1972;25:6.
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Ignore or repair TR Lessons :
TR not important… NO
Not much TR around…. NO
Repair Mitral , TR goes away … NO
Don’t know how to… NO
Add operative mortality to do a TVr… NO
RV will die… NO
Will get TS….. NO
TR : NO, Don’t Ignore it….
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The Surgeon’s Perspective
Concept of Operative Window
Initial Indication
Inoperable Patient
3 to 10 years?
Symptoms, Patient’s age, Comorbidities, Life Expectancy, Type of valve, Patient’s Compliance, etc.
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Minimally Invasive
Cardiac Surgery
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“Minimally Invasive” vs “Standard”
• Concept of “Invasiveness”: 1. Sternotomy / chest scar
2. XClamp time / Time on CPB
3. Postop Pain / Time to full recovery
4. Need for repeated procedures
• Pros and Cons of each
• What type of Patients are the best candidates
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“Standard” Operation: Sternotomy, CPB,
Cardioplegia
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Pros and Cons of “Standard”
• Well known, simple setup
• Better access and control
• Only option for extensive procedures
• Usually less time on CPB
• Less satisfactory cosmetic results
• Hurts a little more but for much longer
• Possibility of sternal non-union or infection
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Path towards less invasive
ON-PUMP
• Mini-Sternotomies
• Mini-Thoracotomies
• Totally endoscopic (Robotic)
OFF-PUMP
• Transfemoral/Transapical (“Catheter” valves)
• New technologies
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Standard AVR
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Conclusions • MR is a “curable” disease and should
be managed with changing indications
in mind
• MV replacement is now accepted as a
treatment for IMR in certain cases and
should be strongly considered if:
– Basal dyskinetic segment
– Significant chord tethering seen
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Conclusions
• Untreated TR can lead to unacceptably
higher rates of M&M and should be
treated at the time of other cardiac
operations
• MICS affords more rapid return to
normal activity but enthusiasm must be
tempered with the known excellent
outcomes achieved with standard
surgery
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REFERENCES
• Enriquez-Sarano, M., et al. (1995). "Valve repair improves the
outcome of surgery for mitral regurgitation. A multivariate
analysis." Circulation 91(4): 1022-1028.
• American College of, C., et al. (2006). "ACC/AHA 2006
guidelines for the management of patients with valvular heart
disease: a report of the ACC/AHA Task Force on Practice
Guidelines (writing Committee to Revise the 1998 guidelines for
the management of patients with valvular heart disease)." J Am
Coll Cardiol 48(3): e1-148.
• Madaric, J., et al. (2007). "Effect of mitral valve repair on
exercise tolerance in asymptomatic patients with organic mitral
regurgitation." Am Heart J 154(1): 180-185.
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REFERENCES
• Acker, M. A., et al. (2014). "Mitral-valve repair versus
replacement for severe ischemic mitral regurgitation." N Engl J
Med 370(1): 23-32.
• Fukuda, S., et al. (2006). "Three-dimensional geometry of the
tricuspid annulus in healthy subjects and in patients with
functional tricuspid regurgitation: a real-time, 3-dimensional
echocardiographic study." Circulation 114(1 Suppl): I492-498.
• Nishimura, R. A., et al. (2014). "2014 AHA/ACC Guideline for
the Management of Patients With Valvular Heart Disease: a
report of the American College of Cardiology/American Heart
Association Task Force on Practice Guidelines." Circulation
129(23): e521-643.
•
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Thank you!!!
?
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