update on hair loss in african american women
TRANSCRIPT
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Update on Hair Lossin African American WomenVictor ia Barbosa MD, MPH, MBA
Mark Al len Everett MD Skin of Color Symposium
Univers ity of Oklahoma
Apri l 23, 2021
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Introduction
Associate Professor, University of Chicago Department of Medicine Section of Dermatology
Director of the Hair Loss Program
Email: [email protected] 773-702-5525FB, IG: @drvickibarbosa
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Disclosure
Consultant for Ambi Skincare
Will not be discussing any skin care products in this lecture
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Professional Practice Gap
Most providers are have limited education on hair care and hair loss in African American women
Providers should be comfortable in discussing hair care practices and diagnosing and managing hair loss in African American women
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Learning Objectives➢What are the unique properties of Black hair?
➢What are the hair styling and hair care practices that we need to be aware of to be culturally competent and to aid in diagnosis and management of hair loss?
➢What are the common causes of hair loss in African American women?
➢How do I diagnose and manage these diseases?
➢What role do hair care and hair products play in disease in African American women?
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Black Hair, Hair Styles and Hair Care
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Black Hair: Curl Pattern
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Black Hair: Breakage & Growth
BREAKAGE
Survival Probability of Different Ethnicities
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Cycles to Failure
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Black Asian Caucasian Latino
GROWTH
Loussouarn G. African hair growth parameters. Br J Dermatol. 2001 Aug;145(2):294-7
◦ 256 (+/- 44) vs 396 (+/- 55) micrometers per day for Blacks vs. Caucasians
◦ 3.68” per year vs. 5.74” per year
The influence of African-American hair's curl pattern on its mechanical propertiesCrystal E Porter 1, Stephane Diridollou, Victoria Holloway Barbosa
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Porosity
How easily does hair retain moisture?
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Hair Grooming: Key Questions
Frequency of shampooing
Conditioning on wash day and in between
Natural vs relaxed◦ Not all hair that is straight is relaxed◦ Relaxer, texturizer, hair color
Use of Heat
Use and frequency of “protective” styling
Use of additional synthetic or human hair extensions
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What Is Natural Hair?
◦ Natural hair is hair that has not been chemically treated
◦ Relaxers are universally considered chemicals and relaxed hair is never considered “natural”
◦ Texturizers are in fact mild relaxers; some people consider themselves to have natural hair even if they use a texturizer because their hair is still curly
◦ Some purists think that if you have hair color then you do not have natural hair; others think that you can have hair color and still be “natural” because hair color does not alter hair texture
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Loose Hair Styles
Wash and go → shrinkage
Short natural
Twist out
Braid out
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Braided Hair Styles aka “Protective Styles”
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Hair Weaving: Sew-in or Glued-in
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Hair Straightening
◦ Use of heat
◦ Hair relaxers
◦ Japanese straightening
◦ Brazilian blowout
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Hair Care Products
Shampoo: Traditional, co-wash/no-poo
Conditioner: Rinse-out, leave-in oils, lotions and creams
Hair Color: Permanent, semi-permanent, temporary
Relaxers: Lye (sodium hydroxide; pH 12-14) , no-lye (calcium, lithium, potassium or guanidine hydroxide, pH 9-11)
Styling: Heat protectors, detanglers, curl enhancers, anti-frizz, shine, oils, gels (hold, twists/locs), etc.
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What Should I Use on My Hair?
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Popular Black-Owned Hair Care Brands
TGIN
Mielle Organics
Girl + Hair
Jane Carter Solution
Kinky-Curly
Mixed Chicks
Camille Rose Naturals
Miss Jesse’s
Taliah Wajiid
Curls
Lusters
Design Essentials
Curl Mix
Coils By Nature
Uncle Funky’s Daughter
Eden Bodyworks
Black Girl Long Hair
Rucker Roots
Briogeo
Hair Rules
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Other Popular Brands
Shea Moisture
Cantu
Carol’s Daughter
ORS
Dark & Lovely
Soft Sheen Carson
African Pride
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Key Points
Reduced frequency of shampooing based on structure and fragility of hair
Increased focus on moisturizing
Use of “protective” styles to reduce breakage at the ends but also to decrease time spent of daily care
Hair care is time consuming and expensive
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“I need to examine your scalp…”
Do you feel comfortable to let me examine your scalp?
Your hair looks beautiful. Are you wearing any extensions today?
How can I best see your scalp?
“I need you to come back after you take your weave/braids/crochet down…”
Avoid “Is that your hair?”
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Traction Alopecia
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Traction Alopecia
Hair loss due to prolonged or recurrent tension on the hair
Initially a non-scarring alopecia, traction may become scarring over time
Mostly reported in women of African descent, also seen in AA men, ballerinas, Sikhs, recently reported in Orthodox Jewish woman,
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TA: Prevalence
SOUTH AFRICAN WOMEN
Dr Khumalo et al studied 874 adults in Capetown, including a survey and physical exam:
◦ TA found in 31.7% of women and 2.2% of men
◦ TA found in 48% of women with relaxed hair and braided extensions
Khumalo NP, Jessop S, Gumedze F, Ehrlich R. Hairdressing and the prevalence of scalp disease in African adults. Br J Dermatol. 2007 Nov;157(5):981-8.
SOUTH AFRICAN GIRLS
Dr. Khumalo et al studied 1042 school children in Capetown, including a survey and physical exam:
◦ TA found in 8.6% of girls in their first year of school vs. 21.7% of girls in their last year of high school
◦ TA was found in 22.9% of girls with no relaxer and 32.1% of girls with a relaxer
◦ This trend was not statistically significant
Khumalo NP, Jessop S, Gumedze F, Ehrlich R. Hairdressing is associated with scalp disease in African schoolchildren. Br J Dermatol. 2007 Jul;157(1):106-10.
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TA: Associations in African American Girls
Dr. Rucker Wright et al surveyed 201 caregivers of AA girls to evaluate hair care practices and association with disease:
◦ N=98 from derm clinic, n=103 from non-derm clinic
◦ Mean age 9.6 +/- 4.4
◦ Ponytails worn by 81%, braids worn by 67% and cornrows worn by 49% in the last 12 months
◦ Cornrows were statistically significantly related to TA, OR 5.79
Rucker Wright D, Gathers R, Kapke A, Johnson D, Joseph CL. Hair care practices and their association with scalp
and hair disorders in African American girls. J Am Acad Dermatol. 2011 Feb;64(2):253-62.
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Traction Alopecia: Clinical Presentation
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Traction Alopecia: Management
Discontinue hair styles that cause the hair to pull
Protect the hair from rubbing on hats and wigs
Topical or intra-lesional steroids
Topical minoxidil
Oral antibiotics
Hair transplant
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What’s New?Frequent braiding contributes to damage to the hair fiber as well as to traction alopecia (IJCS)
Prevalence of TA 7.4% in a study of 428 Nigerian secondary school students (PAMJ)
Report of oral minoxidil use for TA (DT)
Quantifying the impact of braiding and combing on the integrity of natural African hair. Molamodi K, Fajuyigbe D, Sewraj P, Gichuri J, Sijako B, Galliano A, Laurent A. Int J Cosmet Sci. 2021 Feb 19.
Cutaneous disorders of adolescence among Nigerian secondary school students. Oyedepo JT, Katibi OS, Adedoyin OT. Pan Afr Med J. 2020 May 27;36:36.
Case series of oral minoxidil for androgenetic and traction alopecia: Tolerability & the five C's of oral therapy. Beach RA. Dermatol Ther. 2018 Nov;31(6):e12707
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Traction: Be Prepared
Traction alopecia is 100% preventable
Every interaction with an African American patient is an opportunity for 30 seconds of life changing education
Encourage patients to rotate hair styles
Have a list of “go to” cosmetologists
Keep an open mind to the differential
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Alopecia Areata
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Alopecia Areata: Ophiasis Pattern
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Alopecia Areata: Clinical Presentation
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Alopecia Areata: Management
Topical steroids
Anthralin .5 - 1%
Intralesional triamcinolone◦ ILK 5-10 mg/cc
Topical Immunotherapy◦ Squaric acid dibutylester*
◦ Diphenylcyclopropenone
◦ Dinitrochlorobenzene
*Penn State Hershey Protocol
Systemic Treatments◦ Prednisone
◦ Azathioprine
◦ Methotrexate
◦ Cyclosporin
◦ Sulfasalazine
◦ Ezetimibe-simvastatin
◦ JAK Inhibitors (topical, oral)
Adjunctive Treatments◦ Minoxidil
◦ PRP
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Alopecia Areata in African Americans: What’s New?
9340 AA Patients from the NAAR registry identified (JAAD)◦ African Americans had a higher odds of AA compare to Caucasians (OR 1.77; 95% CI, 1.37-2.2
◦ Asian Americans had a lower odds of AA compared to Caucasians (OR 0.40; 95% CI, 0.32-0.50
63,960 women from the Nurses' Health Study (NHS) and 88,368 women from the Nurses' Health Study II (NHSII); 418 and 738 cases of AA, respectively (JID)
◦ NHS: OR 2.72 (95% CI 1.61-4.61) amongst black women as compared with white women
◦ NHSII: OR 5.48 (95% CI 4.10-7.32) amongst black as compared with white women.
◦ NHSII Hispanic Women: OR 1.94 (95% CI 1.24-3.02) in Hispanic compared with non-Hispanic white women.
Racial characteristics of alopecia areata in the United States. Lee H, Jung SJ, Patel AB, Thompson JM, Qureshi A, Cho E. J Am Acad Dermatol. 2020 Oct;83(4):1064-1070.
Race and Alopecia Areata amongst US Women. Thompson JM, Park MK, Qureshi AA, Cho E. J Investig Dermatol Symp Proc. 2018 Jan;19(1):S47-S50.
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Frontal Fibrosing Alopecia
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Frontal Fibrosing Alopecia
Primary lymphocytic cicatricial alopecia
Affects anterior hairline, eyebrows; may have loss of body hair
May have facial papules or hyperpigmentation associated
First reported in 1994, seeing increase in frequency
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FFA: Clinical Presentation
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FFA: Management
Topical
◦ Steroids
◦ Calcineurin inhibitors
◦ Minoxidil
Intralesional steroids
Systemic treatment
◦ Anti-inflammatory doxycycline or hydroxychloroquine
◦ 5 alpha reductase inhibitors
Recalcitrant disease
◦ Retinoids
◦ Immunosuppressive medications
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FFA: What’s New
Lots of questions!
-Why are we seeing an increase in the prevalence of this condition
-Sunscreen controversy
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Central Centrifugal Cicatricial Alopecia
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CCCA: Etiology & Epidemiology
Limited understanding of the role of genetics, androgens, grooming, sources of inflammation
Dlova et al, JAAD 2014
◦ Studied 14 families with 31 family members; pedigree analysis suggested AD inheritance
Suchinwanit et al: IJD 2016
◦ 38 women with bx proven CCCA
◦ Severity was correlated with duration
◦ Androgen related conditions were prevalent
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CCCA: Etiology & Epidemiology
Gaithers et al conducted a retrospective survey◦ 21% had noticed thinning by age 30; 44% by 40
◦ CCCA patients were more likely to have a sister with hair loss than non-CCCA patients
◦ No correlation with hot combs, relaxer use, h/o burns
◦ CCCA patients more likely to have had cornrows/braids with added hair & weaves, and have worn them for a longer time
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Complaint of hair loss, breakage or pruritus
Often sent by hair stylist
Several years duration
May have seen other dermatologists
Usually have not used any treatment
+/- family history
CCCA: Clinical Presentation
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Thinning at the vertex
Progression centrifugally
Loss of hair follicles
No inflammation noted
+/- scale
Some have itching, burning or tingling
CCCA: Physical Examination
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Early CCCA
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End Stage CCCA
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CCCA: Breakage at the Crown
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Management Goal #1: Halt Progression
Topical or intralesional steroids◦ High potency topicals used qd or bid
◦ Give patient a choice as to which vehicle, solution, ointment or foam
◦ ILK 5 to 10 mg/cc as tolerated monthly
◦ Depends on amount of scalp involved and patients willingness
Oral ◦ Doxycycline 100 mg bid or minocycline 100 mg bid
◦ Plaquenil
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Management Goal #2:Encourage Regrowth
Topical or oral minoxidil
Spironolactone
Finasteride
Supplements
PRP
Hair transplantation when stable
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CCCA: What’s New?
Variant PADI3 in Central Centrifugal Cicatricial Alopecia.Malki L et al. N Engl J Med. 2019 Feb 28;380(9):833-841.
Exome sequencing, protein modeling, immunofluorescence staining, etc.
1 splice site and 3 mutations in PADI3
PADI3 encodes peptidyl arginine deiminase, type III
This enzyme is involved in post-translational protein modification of proteins involved in hair shaft formation
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Hair Care and Health
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Are Relaxers Harmful to Our Health?
No data demonstrating an association between relaxer use and CCCA
One study showing that women diagnosed with fibroids are more likely to have used hair relaxers
Hair relaxer use and risk of uterine leiomyomata in African-American women (Wise, et al, American Journal of Epidemiology 2012)
BWHS: 23,580 premenopausal women IRR 1.17 (95% CI 1.06-1.30)
Two recent studies demonstrating an association between relaxer use and the development of breast cancer
Skin lighteners and hair relaxers as risk factors for breast cancer: results from the Ghana breast health study (Brinton et al, Carcinogenesis 2018)
1131 invasive breast cancer patients and 2106 population controls. OR of 1.58 (95% CI 1.15–2.18)
Hair dye and chemical straightener use and breast cancer risk in a large US population of black and white women (Eberle et al, International Journal of Cancer 2020)
46,709 women ages 35-74, 2003 -2009; 2,794 breast cancers identified. Relaxer use was associated with breastcancer risk (OR = 1.18, 95% CI 0.99-1.41
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Is Hair Dye Harmful to Our Health?
Lymphoma ◦ Conflicting data◦ Women who started using hair dye before 1980 had a 30% increased risk
of developing NHL compared to women who never used hair dye
Leukemia◦ Conflicting data
Bladder cancer◦ Small increase in risk among cosmetologists but not among hair dye
users
Breast Cancer◦ Conflicting data◦ Historically, thought leaned against an association◦ Recent data suggests an association between hair dye use and
African American women
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Endocrine DisruptorsNatural or man-made chemicals that mimic or interfere with the body’s hormones
Linked with developmental, reproductive, neurological, immunological and other problems.
Atrazine: weed killer, water contaminant
Bisphenol A (BPA) : canned foods, plastic bottles
Dioxins : forms in industrial processes, found in animal products
Estrogens: hair growth products
Glycol ethers: found in sunscreen and cosmetics (humectant, emollient)
Parabens: preservative in hair care products
Perchlorate : rocket fuel, water contaminant, produce
Polyfluoroalkyl Substances (PFAS): water contaminant, non-stick pans
Phthalates: plastic containers, “fragrance”
Phytoestrogens: soy
Polybrominated diphenyl ethers (PBDE) : flame retardant
Polychlorinated biphenyls (PCB) : banned coolant, contaminant
Triclosan: antimicrobial soaps
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Estrogens and Anti-Estrogens in Hair Products
Estrogenic and anti-estrogenic activity of off-the-shelf hair and skin care products (Myers et al, Journal of Exposure Science and Environmental Epidemiology 2015)
◦ Evaluated 8 hair and skin care products commonly used by AA women for estrogenic and antiestrogenic activity using a cell proliferation assay
◦ 4/8 products, including a hair oil, demonstrated estrogenic activity
◦ 3/8 products, including a placenta conditioner and a tea tree oil hair conditioner, demonstrated anti-estrogenic activity
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Endocrine Disruptors in Hair Products
Measurement of endocrine disrupting and asthma-associated chemicals in hair products used by Black women (Helm et al, Environmental Research 2018)◦ Used GC/MS to test 18 hair products in 6 categories used by
Black women: hot oil treatment, anti-frizz/polish, leave-in conditioner, root stimulator, hair lotion, and relaxer
◦ Tested for 66 chemicals belonging to 10 chemical classes: ultraviolet (UV) filters, cyclosiloxanes, glycol ethers, fragrances, alkylphenols, ethanolamines, antimicrobials, bisphenol A, phthalates, and parabens
◦ 45 chemicals were found, belonging to all 10 classes◦ Root stimulators, hair lotions, relaxers, anti-frizz ◦ 84% of ingredients found were not listed on the labels
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Early Menarche
Childhood hair product use and earlier age at menarche in a racially diverse study population: a pilot study (James-Todd et al, Annals of Epidemiology 2011)
◦ 300 AA, African-Caribbean, Hispanic, and white women ages 18-77 years of age.
◦ Data collected retrospectively on hair oil, lotion, leave-in conditioner, perm, and other types of hair products used before age 13.
◦ Women reporting childhood hair oil use had an increased risk for early menarche (RR 1.4, 95% CI 1.1-1.9)
◦ Hair perm users had an increased risk for earlier menarche (ARR 1.4, 95% CI 1.1-1.8)
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Early Menarche
Hair product use, age at menarche and mammographic breast density in multiethnic urban women (McDonald et al, Environmental Health, 2018)
◦ 248 women from 2 cohorts
◦ Examined childhood and adulthood use of hair oils, lotions, leave-in conditioners, root stimulators, perms/relaxers, and hair dyes
◦ Childhood “ever use” of any hair product and specifically use of hair oil were associated with a higher probability of reaching menarche before 11 years of age
◦ Postulates product use may increase risk of breast cancer
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Conclusion
More information is needed regarding etiology and pathogenesis of these diseases
Clarification of the role of grooming practices in disease progression is needed
Evidence-based treatment approaches are lacking for many conditions
Education of patients, stylists and the general population is key to early diagnosis and treatment compliance
More and better treatments are needed