update in trauma anesthesia 2017 · 2018-05-10 · anesthesia 2018 arana spring meeting may 5th,...
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UPDATE IN TRAUMA
ANESTHESIA 2018ARANA Spring Meeting
May 5th, 2017
Joe Romero CRNA, MS, CPT USAR
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UPDATE IN TRAUMA ANESTHESIA 2018
- An overview of trauma
demographics, mechanisms, and
current literature to support clinical
decisions in trauma anesthesia.
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CONFLICTS OF INTEREST
- Neither I, nor any immediate family
member has any financial or
commercial interest related to this
presentation.
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LEARNING OBJECTIVES
1. Conduct a thorough preoperative assessment
of a trauma patient.
2. Understand the pathophysiology of trauma.
3. Understand the fundamentals of massive
transfusion.
4. Be able to apply current resuscitation
strategies to a trauma patient.
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DEMOGRAPHICS
• More than 9 people die every minute from
injuries or violence worldwide.1
• Motor vehicle crashes alone cause more than
1 million deaths annually, an estimated 20-50
million significant injuries, and are the leading
cause of death due to injury worldwide.2
• Costs of global trauma related deaths are
estimated to exceed $500 billion annually. 2
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DEMOGRAPHICS
• National Trauma Data Bank
• It contains close to 7.5 million records. The 2017 Annual
Report reviews 2016 admissions submitted in the 2017 Call for
Data, totaling 861,888 records with valid trauma diagnoses.3
• The goal of the NTDB is to inform the medical community,
the public, and decision makers about a wide variety of
issues that characterize the current state of care for injured
persons in our country.
• It has implications in many areas, including epidemiology,
injury control, research, education, acute care, and
resource allocation.
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DEMOGRAPHICS
• NTDB Hospitals:
• 747 hospitals submitted data to the NTDB in 2015.
• 239 are Level I centers
• 263 are Level II centers.
• 196 are Level III or Level IV centers.
• 36 are Level I or Level II pediatric-only centers.
• 64.26% of participating centers reported including all
hip fractures (in accordance with NTDB inclusion
criteria).
• 91.70% reported including DOAs in their registries.
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DEMOGRAPHICS
NTDB 2016
• Injuries initially peak in ages 14 to 29 , primarily from MVT-
related incidents, and peak again between the ages of 40 and 50, when falls begin to increase.
• Males account for 70% of all incidents up to age 70, after age 71, most patients are female.
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DEMOGRAPHICS
NTDB 2016
• Falls account for 44.18% of cases in the NTDB, with injuries increasing in children under age 7 and adults over the age of 75.
• Motor vehicle traffic-related injuries account for 25.97% of cases
in the NTDB, with a dramatic rise between ages 16 and 26, peaking around age 21.
• At age 12, firearm injuries double and steadily increase until age 22, then decrease afterwards.
• Suffocation, drowning/submersion injuries, and firearm injuries
have the highest case fatality rates, with suffocation at 27.12%,
drowning/submersion at 19.20%, and firearms at 15.30%,.
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National Trauma Data Bank 2016
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National Trauma Data Bank 2016
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National Trauma Data Bank 2016
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National Trauma Data Bank 2016
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DEMOGRAPHICS
• Over the last 10 years, deaths from trauma
have increased 23%.2
• 32% more deaths occur from trauma than in
Malaria, HIV, and TB combined.2
• By 2030, it is predicted that deaths from MVC will be the 5th leading cause worldwide.1
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TRIMODAL DEATH IN TRAUMA
• Fatalities either occur:
• 1. At the scene
• 2. Within the first 6 hours at the hospital
• 3. After 6 hours due to acute lung injury or multiorgan failure
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DEMOGRAPHICS
• 25-35% of severe traumatic injuries are
significantly coagulopathic.5
• Of patients who reach the hospital alive,
hemorrhage is the most reversible cause of
death.5
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PATHOPHYSIOLOGY OF TRAUMA
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PATHOPHYSIOLOGY OF TRAUMA
• The Lethal Triad of Trauma:
• 1. Coagulopathy
• 2. Hypothermia
• 3. Acidosis
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PATHOPHYSIOLOGY OF TRAUMA
• Coagulopathy associated with traumatic
injury is the result of multiple independent but
interacting mechanisms.
• Early coagulopathy is driven by shock and
requires thrombin generation from tissue injury
as an initiator.8
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PATHOPHYSIOLOGY OF TRAUMA
• Activation of the clotting cascade occurs from
tissue factor released by endothelial damage.
• Eventually this leads to the formation of a
stable fibrin clot.
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PATHOPHYSIOLOGY OF TRAUMA
• Shock leads to hypoperfusion and a
hyperfibrinolytic state due to increases in
thrombomodulin and protein C.
• Thrombomodulin binds to thrombin – pulling it
out of the coagulation cascade
• Protein C is thought to be the main cause of
hyperfibrinolysis. It deactivates clotting factors
and increases endogenous Tissue Plasminogen
Activator (TPA).
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PATHOPHYSIOLOGY OF TRAUMA
• Coagulopathy also occurs in hemorrhage due
to losses of clotting factors and platelets.
• Transfusion of only red bloods cells further
dilutes clotting factors.
• Adding LR or saline further hemodilutes and
compounds the existing coagulopathy.
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PATHOPHYSIOLOGY OF TRAUMA
• Hypothermia:
• 1. Occurs from the point of injury, ED, and the OR.
• 2. Temperature <34°C inactivates coagulation
factors and platelets
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PATHOPHYSIOLOGY OF TRAUMA
• Acidosis:
• 1. Secondary to hypoperfusion
• 2. Lower pH inactivates important coagulation
factors (<7.2)
• 3. Administration of saline (large volume of chloride)
compounds acidosis by causing iatrogenic
hyperchloremic acidosis
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PRINCIPLES OF TRAUMA CARE
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MNEMONICS, CHECKLISTS, ALGORITHMS
• Facilitate rapid overview to differentiate
between stable, unstable, and dying
patients, and how we can treat them in
emergency situations.
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MNEMONICS, CHECKLISTS, ALGORITHMS
• ABC — primary survey of Airway, Breathing,
and circulation;
• D — Secondary survey of Disability (neuro eval)
• E — Tertiary survey of Exposure
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AIRWAY & BREATHING
• Assume spinal injury and full stomach
• Evaluate effects of any facial or mandibular
fracture
• Assess for occult tracheal or laryngeal injury that
might preclude intubation
• Consider flail chest
• Consider pneumothorax and hemothorax
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AIRWAY PEARLS
• Check for foreign bodies
• Perform chin lift or jaw thrust
• Consider cricothyroidotomy early (convert to
tracheostomy later, when patient stable)
• Do not perform cricothyroidotomy in children;
consider transtracheal insufflation
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CRICOTHYROIDOTOMY
• Three Step Method4:
• 1. Locate cricothyroid membrane and make a
vertical incision.
• 2. Insert an elastic bougie.
• 3. Advance endotracheal tube over the
bougie.
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TRANSTRACHEAL INSUFFLATION:
• Use14-gauge needle and penetrate
cricothyroid membrane
• Connect to third leg of Y connector
• Connect high-pressure oxygen to one leg and
leave last leg open to atmosphere;
intermittently occlude atmosphere leg
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CIRCULATION
Establish Large Bore IV Access:
• 14g-18g catheter
• Less emphasis on CVC (Poiseuille’s Law)
• Consider Rapid Infusion Catheter (RIC)
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CIRCULATION
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HEMORRHAGE AND SHOCK
Prospective Observational Multicenter Major
Trauma Transfusion (PROMMTT)10 study (2013):
• Patients who received higher ratios of plasma
to red blood cells, and platelets to red blood
cells, had decreased mortality at 6 hr
• Patients who received less FFP had 3-fold to 4-
fold greater likelihood of dying <6 hr
• No difference in mortality at 24 hr or 30 days
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HEMORRHAGE AND SHOCK
Prospective Observational Multicenter Major
Trauma Transfusion (PROMMTT)10 study (2013):
• Patients who received FFP ≤2.5 hr, 24-hr and
30-day mortality decreased
• Patients who received FFP and platelets after
first receiving PRBCs did worse
• Conclusion: Attempt to give plasma and
platelets initially to reverse coagulopathy early
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HEMORRHAGE AND SHOCK
Prospective Randomized Optimal Platelet Plasma Ratio
(PROPPR) trial (2015)11:
• Randomized MTP transfusion ratios of plasma to
platelets to red cells of either 1:1:1 or 1:1:2
• Death from hemorrhage significantly less in 1:1:1 group
at 3 hr
• No significant differences at 24 hr or 30 days, which
implies no increased risk for death from complications
of blood transfusion (eg, renal failure, ARDS)
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HEMORRHAGE AND SHOCK
CRASH-2 Trial (2013)13 :
A randomized controlled trial and economic evaluation
of the effects of tranexamic acid on death, vascular
occlusive events and transfusion requirement in bleeding
trauma patients.
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HEMORRHAGE AND SHOCK
CRASH-2 Trial (2013)13:
• Early administration of TXA safely reduced the risk of
death in bleeding trauma patients
• Treatment beyond 3 hours of injury is unlikely to be
effective.
• Highly cost-effective
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TRIGGERS FOR MASSIVE TRANSFUSION
ABC Scoring for MTP14:
• Penetrating mechanism (+1)
• ER HR > 120 (+1)
• ER SBP < 90mmHg (+1)
• Positive FAST exam (+1)
ABC > 2 = Consider MTP
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HEMORRHAGE AND SHOCK
• RBC Transfusion:
• Not indicated until hemoglobin falls below 7g/dL
• If known cardiovascular disease, transfuse at 8g/dL
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HEMORRHAGE AND SHOCK
Treatment:
• Permissive hypotension (Goal MAP 60)7
• Ideally administer warm fresh whole blood
(WFWB) or its equal components8,9,10
• Administer Blood products 1:1:1 (plasma,
platelets, PRBCs,)8,9,10,11,12
• Minimize crystalloid (1L or less)8,9,11
• Administer Tranexamic Acid if injury <3 hours
prior14
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HIDDEN BLOOD LOSS
• Drain and monitor hemothorax
• Evaluate abdomen
• Evaluate retroperitoneum
• Evaluate pelvis and consider pelvic binder
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CIRCULATION
5ATLS Student Course Manual 2012
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OTHER CONSIDERATIONS
Tension pneumothorax:
• Treat with needle decompression
• Insert needle above rib in second
intercostal space at midclavicular line
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OTHER CONSIDERATIONS
Cardiac Tamponade:
• Consider mechanism of injury
• Classic presentation venous
hypertension with shock
• Pericardial window preferred over
pericardiocentesis
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OTHER CONSIDERATIONS
Blunt Cardiac Injury:
• Consider mechanism of injury
• Electrocardiography (ECG) nonspecific
• Cardiac enzymes rarely helpful
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OTHER CONSIDERATIONS
Neurogenic Shock:
• Cervical or thoracic spinal cord injury
• Presentation bradycardia and
vasodilation
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SECONDARY SURVEY
• AMPLE Mnemonic:
• Allergies
• Medications
• Past medical history
• Last meal
• Event surrounding illness
• Fully expose patient and assess, then
cover patient to prevent hypothermia
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ADDITIONAL CONSIDERATIONS
• Insert nasogastric tube
• Antibiotics as indicated
• Obtain specialty consultations if needed
• Tetanus prophylaxis
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BURN INJURY
• Assess upper and lower airway injury
• Consider bronchoscopy and early
intubation
• Avoid succinylcholine after 24hrs
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ASSESSING SEVERITY OF BURNS
• Consider rule of 9s
• First degree: erythema and pain
• Second degree — partial thickness,
blisters
• Third degree — nerves destroyed, so
painless
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CHEMICAL BURNS
• Severity of injury related to concentration of
agent and duration of exposure
• Remove all clothing, brush off dry agent,
irrigate with water
• Wear personal protective gear
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ELECTRICAL INJURY
• Evaluate entry and exit wounds
• Evaluate distant secondary burns
• Consider ignition injury, cardiac arrest,
falls, and rhabdomyolysis
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PEDIATRIC CONSIDERATIONS
• Treat as “little adults”
• Perform orotracheal intubation with in-line
stabilization
• Greater risk for injury from cricothyroidotomy
than with adults
• Greater risk for hypothermia
• Any time the story inconsistent with injury,
consider child abuse and evaluate
appropriately
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OR CHECKLIST FOR TRAUMA PATIENTS
Prior to arrival:
• Room temperature 25C (77F) or higher
• Warm IV Line
• Airway Equipment
• Emergency Medications
• Blood Bank: 6U O neg PRBC, 6 AB FFP, (1) 6-
pack PLT available
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OR CHECKLIST FOR TRAUMA PATIENTS
Patient Arrival :
• Patient ID’d for emergency surgery
• Blood Bank: Send blood for T&C and iniate
MTP
• IV access
• Monitors
• Surgeon: Prep & Drape
• Pre-02
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OR CHECKLIST FOR TRAUMA PATIENTS
Induction:
• Sedative hypnotic (ketamine v. propofol v.
etomidate)
• Neuromuscular Blockade (succ v. Roc)
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OR CHECKLIST FOR TRAUMA PATIENTS
Resuscitation:
• Send baseline labs
• Follow MAP trends
• Goal 1:1:1 FFP, PLT, PRBC
• Goal Urine output 0.5-1ml/kg/hr
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OR CHECKLIST FOR TRAUMA PATIENTS
Resuscitation (cont):
• Consider TXA if <3 hr after injury, 1gm over
10mins, then 1gm over 8 hours
• Consider Calcium chloride 1gm
• Consider hydrocortisone 100mg
• Consider vasopressin 5-10 IU
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OR CHECKLIST FOR TRAUMA PATIENTS
Resuscitation (cont):
• Administer appropriate antibiotics
• Special considerations for TBI:
• SBP>90-100, Sa02>90%, PC02 35-45mmHg
• Initiate low lung volume ventilation (TV=
6ml/kg IBW
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QUESTIONS?
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REFERENCES1. World Health Organization (WHO). Injuries and violence: the facts. Geneva, Switzerland: WHO; 2010.
2. World Health Organization (WHO). The global burden of disease: 2004 update. Geneva, Switzerland: WHO; 2008.
3. National Trauma Data Bank 2016 Annual Report. National Trauma Data Bank. Accessed March 21, 2017. https://www.facs.org/quality-programs/trauma/ntdb
4. Quick J, MacIntyre A, Barnes S: Emergent surgical airway: comparison of the three-step method and conventional cricothyroidotomy utilizing high-fidelity simulation. J Emerg Med 2013
5. Advanced Trauma Life Support. ATLS Student Course Manual. American College of Surgeons. Chicago, IL; 2012
6. Hess JR et al: The coagulopathy of trauma: a review of mechanisms. J Trauma 2009 Jun;66(6):1616-24
7. Bickell WH et al: Immediate versus delayed fluid resuscitation for hypotensive patients with penetrating torso injuries. N Engl J Med 1994; 331:1105-1109
8. O’Keeffe T et al: A massive transfusion protocol to decrease blood component use and costs. J Trauma 2008 Oct;65(4):951-60;
9. Lier H et al: Preconditions of hemostasis in trauma: a review. The influence of acidosis, hypocalcemia, anemia, and hypothermia on functional hemostasis in trauma. J Trauma 2007 Feb;62(2):307-10
10. Holcomb JB et al: The prospective, observational, multicenter, major trauma transfusion (PROMMTT) study: comparative effectiveness of a time-varying treatment with competing risks. JAMA Surg. 2013;148(2):127-136
11. Holcomb JB et al: Transfusion of Plasma, Platelets, and Red Blood Cells in a 1:1:1 vs a 1:1:2 Ratio and Mortality in Patients With Severe Trauma: The PROPPR Randomized Clinical Trial. JAMA. 2015 Feb 3; 313(5): 471–482.
12. Holcomb JB et al: Damage control resuscitation: directly addressing the early coagulopathy of trauma. J Trauma. 2007;62:307–310.
13. Roberts I et al: The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients. Health Technol Assess. 2013 Mar;17(10):1-79
14. Cotton BA et al: Multicenter validation of a simplified score to predict massive transfusion in trauma. J Trauma 2010 Jul;69 Suppl 1:S33-9
15. Lier H et al: Preconditions of hemostasis in trauma: a review. The influence of acidosis, hypocalcemia, anemia, and hypothermia on functional hemostasis in trauma. J Trauma 2007 Feb;62(2):307-10