university of pennsylvania c a m b news from the · university of pennsylvania summer 2007 ... and...

University of Pennsylvania Summer 2007

Cell and Molecular Biology Graduate Group

News from the C A M BC A M B

The 2007 CAMB Symposium will be

Monday, October 1st.

At the Annenberg Center.

The keynote speaker will be

Dr. Craig Thompson.

Dr. Thompson joined Penn in 1999 as a Professor of Medicine, Scientific Director of The Leonard and Madlyn Abramson Family Cancer Research Institute, and Penn’s first Chair of the Department of Cancer Biology. He is now also the Direc-tor of the Abramson Cancer. Last year, he was elected a member of the prestigious National Academy of Sciences, an honor awarded to only four cancer scientists in 2005. After an undergraduate career at Dart-mouth College and graduate training at

Dartmouth Medical School, Dr. Thompson received his MD degree from the University of Pennsylvania in 1977. He received clinical training in Internal Medicine at Harvard University and in Medical Oncology at the Fred Hutchinson Cancer Research Institute at the University of Washington. In 1987, Dr. Thompson joined the faculty of the University of Michigan as an Assistant Professor in Medicine and an Assistant Investigator in the Howard Hughes Medical Insti-tute. In 1993, he moved to the University of Chicago and was pro-moted to Professor of Medicine, Investigator in the Howard Hughes Medical Institute, and Director of the Gwen Knapp Center for Lupus and Immunology Research. Dr. Thompson currently serves as Chairman of the Medical Advi-sory Board of the Howard Hughes Medical Institute, Vice Chairman of the GM Cancer Research Prize Committee, a member of the Lasker Prize Jury, and as an Associate Editor of Cell, Science, Immu-nity, and Cancer Cell. Dr. Thompson is the holder of a number of pat-ents related to immunotherapy and apoptosis, and is a founder of two biotechnology companies. In addition to the National Academy of Sciences, Dr. Thompson is an elected member of the Institute of Medicine, the American Academy of Arts and Sciences, the American Society for Clinical Investigation, and the American Association of Physicians. **bio from SOM press release

The CAMB Annual Symposium is a full day (8:30 –6:00) of sci-ence and social interaction for CAMB faculty and students. Talks will be presented by three faculty and six students, as well as the keynote speaker.

All thesis level students are expected to present posters, and all other CAMB students may volunteer to do so. A panel of faculty judges will award $100 prizes to the top posters at the end of the day.

Most pictures in this newsletter are from our

Ice Cream Social

Held on July 13th

CAMB News Letter , Summer 2007

Lara Abramowitz University of Rochester

Joshua Abrams

North Carolina State University

Lauren Bayne

Bucknell University

George Buchlis Cornell University

Xiwen Chen

Nanjing University

Elizabeth Cramer

Penn State University

Korey Demers

Case Western Reserve University

Christopher Dupont

Suny College at Geneseo

Dan Feng

Tsinghua University

Erin Frey

Desales University

Sarah Fintushel University of Michigan

Eric Friske

University Wisconsin Madison

Please join us in welcoming the 36 CAMB PhD students who will matriculate in 2007

Skye Geherin

Virginia Polytechnic

Elise Giantomaso

Drexel University

Arielle Glatman Zaretsky

Brown University

Tagan Griffin

Arizona State University

Jason Jung

University California Berkeley

Rachel Kadzik

Oberlin College

Rebecca Lijek

Haverford College

Julie Magallanes

University California Los Angeles

Elizabeth Morton

University of Montana

Matthew Pace

St Joseph's University

Arun Padmanabhan

Washington University

Carolina Pombo-Martinez

Barry University

Admission Season 2007

The 2008 admission weekends will be:

January 17th – 19th

February 7th – 9th

February 28th – March 1st

Please put these dates on your calendar.

The CAMB office would like to thank everyone involved this season for their hard work, especially the student leaders:

Balpreet Bhogal, Stacie Dilks, Margaret Fleetwood, Kelly Howell, Andrew J. Rennekamp, Steven Saenz, Adam Seibert, Elia Tait and Katie Wharry

Ruchira Ranaweera

Rutgers University New Brunswick

Emma Reuschel Illinois College

Allison Rosenberg

Haverford College

Hannah Schoch Drexel University

Zhewei Shen

University California Los Angeles

Juliana Small Rutgers University New Brunswick

Kristin Toscano University of Florida

Nathan Vande Burgt Calvin College

Jason Wojcechowskyj University Wisconsin Madison

Gabrielle Wong University California Berkeley

Te-Lang Wu University of Pennsylvania

Allison Zajac University of Pennsylvania


August Graduation

10 CAMB students received PhDs in August 2006.

Michael Buckstein Advisor: Harvey Rubin "A Novel HPLC Based Approach to Characterizing and Quantitating Nucleotide Pools in Bacteria"

Marcus Gustafsson Advisor: Charles Emerson& Daniel Kessler “Regulation of Epaxial Myogenesis and MYF5 Expression by SHH Signaling, GLI Activation, and BMP Antago-nism”

Scott E. Hensley Advisor: Hildegund Ertl "The Effects of Type I Interferons Following Vaccination with Adenovirus Vectors”

Manami Nishi Advisor: David Roos "Cell Cycle Regulation of Organelle Biogenesis and Api-coplast Protein Trafficking in Toxoplasma Gondii"

Chelsea C. Pinnix Advisor: Meenhard Herlyn "Notch1 Activation Confers Transforming Properties to Primary Human Melanocytes and Promotes Human Mela-noma Progression “

Evan C. Ray Advisor: Carol Deutsch "The Role of Intracellular Cations in Kv Channel Gating"

Anna F. Rives Advisor: Stephen DiNardo “Endocytosis and Signaling in the Drosophila Wingless (WNT-1) Pathway ”

Claudia E. Robert Advisor: Bryan Wolf "Characterization of a Transgenic Mouse Tissue-Specifically Overexpressing Pancreatic Derived Factor (Pander), A Novel, Pancreas Specific Cytokine-Like Mole-cule"

Melissa D. Sanchez Advisor: Robert Doms “Characterization of Neutralizing Antibodies Against West Nile Virus in Mice and Horses"

Robert W. Schnepp Advisor: Xianxin Hua “The Tumor Suppressor Menin Promotes Apoptosis and Inhibits Cell Cycle Progression”

Francesca Duncan Advisor: Carmen Williams & Richard Schultz "The Role of Par-3 (Partitioning Defective Gene-3) in the Development of Asymmetry during Mouse Meiotic Matura-tion "

Penney M Gilbert Advisor: Valerie Weaver "The Role of HOXA9 in Breast Cancer Progression”

Beth Holloway Advisor: Mary Mullins "The Role of Betty Boop, the Zebrafish Homologue of Map-kapk2, During Epiboly”

Lauren Hook Advisor: Harvey Friedman "Herpes Simplex Virus Immune Evasion from Antibody and Complement ”

Yasuhiko Irie Advisor: Ming Yuk "Properties of Surface-Associated Aggregated Growth of Bordetella Bronchiseptica"

Nicholas W. Keiser Advisor: Jean Bennett "Molecular Mechanisms of Two Inherited Retinal Degenera-tions Affecting the Retinal Pigment Epithelium”

Katherine S. Masek Advisor: Christopher Hunter "Calcium Signaling in Innate Recognition of Toxoplasma Gondii"

December Graduation

17 CAMB students received PhDs in December 2006.


May Graduation

8 CAMB students received PhDs in May 2007.

Daria Babushok Advisor: Haig Kazazian “Role of Line-1 Retrotransposon in Genome Evolution: Mechanisms of L1 Integration and L1-Mediated Creation of New Genes”

Monica Buzzai Advisor: Craig Thompson "The Role of AMPK in Modulating the Metabolism and Sur-vival of Cancer Cells"

Tina Franklin-Dumont Advisor: Steve DiNardo "Counting Up Off Schedule: Investigating the Timing of De-velopmental Transitions in the Drosophila Testis”

David Garbe Advisor: Greg Bashaw "Integration and Regulation of Attractive and Repulsive Axon Guidance at the Drosophila Midline"

Steven Gibson Advisor: Greg Enders "Inhibition of Colon Tumor Progression and Angiogenesis by the INK4A/ARF Locus"

Colleen Kane Advisor: Edward Pearce "Helminth Antigens Modulate TLR-Ligand Induced Den-dritic Cell Activation”

Sagar Kudchodkar Advisor: James Alwine "Dealing with Stress: Human Cytomegalovirus Maintains Translation in Cells Under Adverse Conditions”

Erinn Bruno Rankin Advisor: Volker Haase "The Role of Hypoxia Inducible Factor Family Members in the Development of VHL Disease”

Ryan E. Moore Advisor: Daniel Rader "Apolipoprotein A-I Inhibits Atherosclerosis In Vivo by Pro-moting Macrophage Reverse Cholesterol Transport and HDL Anti-Inflammatory and Anti-Oxidant Functions”

Jessica Norman Advisor: Ramin Shiekhattar "Defining Neddylation Pathways and Linking Histone Ubiquitination to Histone Demethylation"

John K Northrop Advisor: Hao Shen "CD4 T Help Dependent Epigenetic Remodeling in Memory CD8 T Cells “

Jagruti Patel Advisor: Steve McMahon "Novel Insights in the MYC Pathway: Regulation of Protein Stability and Apoptosis Induction“

Jason Skinner Advisor: Ming Yuk "Modulation of Host Immunity by Bordetella Bronchiseptica Resulting in Bacterial Colonization of the Lower Respiratioy Tract”

Aaron Steiner Advisor: Daniel Kessler "Fox Family Transcription Factors in the Regulation of Nodal Signaling and Germ Layer Formation“

Jie Sun Advisor: Edward Pearce "Inhibition of TH2 Cell Development by TLR-Activated Dendritic Cells“

James Walters Advisor: Steve DiNardo "Regulation of Cuticle Pattern in the Drosophila Ventral Epidermis: Roles for the Notch Pathway, Modulation of EGF Activation, and Planar Cell Polarity“

Bo Wu Advisor: David Roos "Heme Biosynthetic Pathway in Apicomplexan Parasites“

Yan Zhang Advisor: Andrew Dancis "Characterization of Mitochondrial Carrier Proteins, MRS3P, MRS4P in Rapid, High Affinity Iron Transport into Mitochondria and Frataxin in Providing Mitochondrial Iron for Heme and Iron Sulfur Cluster Biosynthesis“

December Graduation cont,

Class Instructor (s) Day: Time

BIOM 600: Cell Biology and Biochemistry M. Ostap M, W, F: 10:30 - 12:00

CAMB 518: Current Topics in Ion Channels C. Deutsch, F. Horrigan TBD

CAMB 530: Seminar in Cell Growth and Cancer A. Diehl, R. Assoian M: 2-4

CAMB 532: Integrative Physiology M. Pring T, W, F: 2:30 - 4

CAMB 542-401: Topics in Molecular Medicine - (MD / PhD only) M. Kahn, R. Wells W: 3:00 - 5:00

CAMB 542-402: Topics in Molecular Medicine - (VMD/PhD, PhD, and MD/PhD ) M. Atchison W: 5 - 7

CAMB 590: Topics in Microbiology, Virology and Parasitology P. Bates, E. Pearce, R .Doms T, R: 10 - 11:30

CAMB 597: Developmental Neuroscience M. Granato W, F: 10:45 - 12:30

CAMB 605: First Year Seminar D. Epstein T: 1 - 4

CAMB 608: Regulation of Eukaryotic Gene Expression T. Kadesch T: 3 - 5

CAMB 609: Vaccines & Immune Therapeutics D. Weiner, P.Offit, J Boyer W, R: 3-5

CAMB 610: Molecular Basis of Gene Therapy J. Wilson, J. Glick M, W, F: 9 - 10

CAMB 617: Emerging Infectious Diseases H. Shen M, W, F: 10 –11:30

CAMB 620: Molecular Mechanisms of Development S. DiNardo T: 10 -12

CAMB 630: Topics in Human Genetics and Disease

N. Spinner, E. Shore, T. Shaikh, S Grant, M Devoto R: 1:30, 3:30

CAMB 601: Advanced Virology Seminar R. Harty M: 2-3

CAMB 513: Evolution in Cancer C.Maley T,R: 11-1

CAMB Fall Courses

CAMB students - please remember to discuss your course choices with your program advisor and to communicate with your coordinator so that she can register you properly.


Saul Winegrad Awards for Outstanding Dissertation

Sagar Kudchodkar Advisor: James Alwine

Congratulations to:

Erinn Bruno Rankin Advisor: Volker Haase


Recent Papers from Students

Babushok DV, Ohshima K, Ostertag EM, Chen X, Wang Y, Mandal PK, Okada N, Abrams CS, Kazazian, HH, Jr. (2007) A novel testis ubiquitin binding protein gene, S5a-like, arose by exon-shuffling in hominoids. Genome Research, in press. Babushok DV, Ostertag EM, and Kazazian HH, Jr. (2007) Current topics in genome evolution: Mechanisms of new gene formation. Cell and Molecular Life Science, 64:542-554. Babushok DV and Kazazian HH, Jr. (2007) Progress in understanding the biology of the human mutagen LINE-1. Human Mutation, in press. Barbash O, Lin DI, Diehl JA. (2007) SCF Fbx4/alphaB-crystallin cyclin D1 ubiquitin ligase: a license to destroy. Cell Div. 15:2:2. Behr R, Sackett SD, Bochkis IM, Le PP, Kaestner KH (2007) Impaired male fertility and atrophy of seminiferous tubules caused by haploinsufficiency for Foxa3. Developmental Biology. Apr 5 (Epub ahead of print). Bertozzi, C.C., Chang, C.Y., Jairaj, S., Shan, X., Huang, J., Weber, B.L., Chu, C.S., and Carroll R.G. (2006) Multiple initial culture conditions enhance the establishment of cell lines from primary ovarian cancer specimens. In Vitro Dev Biol Anim, 42:58-62. Bonaccorso, F.J, J.R. Winkelmann, D. Shin, C.I. Agrawal, N. Aslami, C. Bonney, A. Hsu, P.E. Jekielek, A. K. Knox, S. J. Kopach, T. D. Jennings, J. R. Lasky, S. A. Menesale, J. H. Richards, J. A. Rutland, A. K. Sessa, L. Zhaurova, T. H. Kunz (2007) Evidence for Exploitative Competition: Comparative Foraging Behavior and Roosting Ecology of Short-Tailed Fruit Bats (Phyllostomidae) Biotropica 39:249–256. Cash, T. P., Y. Pan, and M. C. Simon (2007) Reactive oxygen species and cellular oxygen sensing. Free Radical Biol. Med., in press. Caviston, JP, Ross, JL, Antony, SA, Tokito, M., Holzbaur, ELF. (2007) Huntingtin facilitates dynein/dynactin-mediated vesicle transport. PNAS, in press. Caviston, JP, Holzbaur ELF. (2006) Microtubule motors at the intersection of trafficking and transport. Trends Cell Biol. 16:530-7. Chang, L.L. and D.S. Kessler. (2007). Formation of the Embryonic Mesoderm. In "Principles of Developmental Ge-netics". S.A. Moody, ed. San Diego, Elsevier Inc. In press. Ciuffi A, Diamond TL, Hwang Y, Marshall HM, Bushman FD. (2006) Modulating target site selection during human immunodeficiency virus DNA integration in vitro with an engineered tethering factor. Hum Gene Ther. 17:960-7. PMID: 16972764 Covello, K. L., J. Kehler, H. Yu, J. D. Gordan, A. M. Arsham, C. J. Hu, P. A. Labosky, M. C. Simon,* and B. Keith (2006) HIF-2a regulates Oct-4: effects of hypoxia on stem cell function, embryonic development and tumor growth. Genes & Dev. 20:557-570. *corresponding author Culyba MJ, Harrison JE, Hwang Y, Bushman FD.(2006) DNA cleavage by the A22R resolvase of vaccinia virus. Vi-rology. 352:466-76. PMID: 16781759 Day L, Chau CM, Nebozhyn M, Rennekamp AJ, Showe M, Lieberman PM. (2007) Chromatin profiling of Epstein-Barr virus latency control region. J Virol. 81:6389-401


Recent Papers from Students cont..

Deramaudt TB, Sachdeva MM, Wescott MP, Chen Y, Stoffers DA, Rustgi AK. (2006) The PDX1 homeodomain tran-scription factor negatively regulates the pancreatic ductal cell-specific keratin 19 promoter. J Biol Chem. 281:38385-95. Ditsworth D, Zong WX, Thompson CB. (2007) Activation of poly(ADP)-ribose polymerase (PARP-1) induces re-lease of the pro-inflammatory mediator HMGB1 from the nucleus. J Biol Chem. 282:17845-17854. Epub 2007 Apr 12. Duncan FE, Moss SB, Williams CJ. (2006) Knockdown of the cAMP-dependent protein kinase (PKA) Type Ialpha regulatory subunit in mouse oocytes disrupts meiotic arrest and results in meiotic spindle defects. Dev Dyn. 235:2961-8. Franklin-Dumont, T. M., Chatterjee, C., Wasserman, S. A. and DiNardo, S. (2007) A novel EIF4G homolog, Off-schedule, couples translational control to meiosis and differentiation in Drosophila spermatocytes. Development, in press Garbe DS, Bashaw GJ. (2007) Independent functions of Slit-Robo repulsion and Netrin-Frazzled attraction regulate axon crossing at the midline in Drosophila. J Neurosci. 27:3584-92. Garbe DS, Das A, Dubreuil RR, Bashaw GJ. (2007) beta-Spectrin functions independently of Ankyrin to regulate the establishment and maintenance of axon connections in the Drosophila embryonic CNS. Development 134:273-84. Epub 2006 Nov 22. Gleason, C. E., Lu, D., Witters, L. A., Newgard, C. B., Birnbaum, M. J. (2007) The role of AMPK and mTOR in nutri-ent sensing in pancreatic b–cells J. Biol. Chem. 282:10341-51 Gordan, J. D., and M. C. Simon (2007) Hypoxia inducible factors: central regulators of the tumor phenotype. Curr. Opin. in Genes & Dev. 17:71-77. Gordan, J. D., J. A. Bertout, C.-J. Hu, J. A. Diehl, and M. C. Simon (2007) HIF-2a promotes hypoxic cell proliferation by enhancing c-Myc transcriptional activity. Cancer Cell 11:335-347. Hannah BP, Heldwein EE, Bender FC, Cohen GH, Eisenberg RJ. (2007) Mutational evidence of internal fusion loops in herpes simplex virus glycoprotein B. J Virol. 81:4858-65. Epub 2007 Feb 21.



Hickey, M. M., and M. C. Simon (2006) Regulation of angiogenesis by hypoxia and hypoxia-inducible factors. Curr. Top. Dev. Biol. 76:217-257. High FA, Zhang M, Proweller A, Tu L, Parmacek MS, Pear WS, Epstein JA. (2007) An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation. J Clin Invest. 117:353-63. Hsiao A, Liu Z, Joelsson A, Zhu J. Vibrio cholerae virulence regulator-coordinated evasion of host immunity. Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14542-7. Epub 2006 Sep 18. Hu, C. J., S. Iyer, A. Sataur, K. L. Covello, L. A. Chodosh, and M. C. Simon (2006) Differential regulation of the tran-scriptional activities of hypoxia-inducible factor 1a (HIF-1a) and HIF-2a in stem cells. Mol. Cell. Biol. 26:3514-26. Izeradjene K, Combs C, Best M, Gopinathan A, Wagner A, Grady WM, Deng CX, Hruban RH, Adsay NV, Tuveson DA, & Hingorani SR. (2007) KrasG12D and Smad4/Dpc4 Haploinsufficiency Cooperate to Induce Mucinous Cystic Neoplasms and Invasive Adenocarcinoma of the Pancreas. Cancer Cell. 11:229-243. Kudchodkar, S.B., Yu, Y., Maguire, T.G. and J.C. Alwine. (2006). Human Cytomegalovirus Alters the Substrate Specificities and Rapamycin Sensitivities of Raptor- and Rictor-Containing Complexes. PNAS 103:14182-14187. Kudchodkar, S.B., DelPrete, G.Q., Maguire, T.G. and J.C. Alwine. (2007). AMPK-Mediated Inhibition of mTOR Kinase Is Circumvented during Immediate-Early Times of Human Cytomegalovirus Infection. J. Virol. 81:3649-3651. Lamonica JM, Vakoc CR, Blobel GA. (2006) Acetylation of GATA-1 is required for chromatin occupancy. Blood. 108:3736-8. Lee, J.Y., Kozak, M., Martin, J.D., Pennock, E and Johnson, F.B. (2007) Evidence that a RecQ Helicase Slows Senes-cence by Resolving Recombining Telomeres. PLOS Biology, in press. Lee JS, Yu Q, Shin JT, Chen M, Bertozzi C, Mericko P, Stadtfeld M, Zhou D, Cheng L, Graf T, MacRae CA, Lepore JJ, Lo C, Kahn ML. (2006) Klf2 is an essential regulator of vascular hemodynamic forces in vivo. Dev Cell 11:845-57. Lee, R., M. Limberis, M. F. Hennessey, J.M. Wilson and J.K. Foskett. (2007) Optical imaging of Ca2+-evoked fluid secretion by murine nasal submucosal gland serous acinar cells. J. Physiol. (in press). Levy, JR, Holzbaur, ELF. (2007) Special Delivery: Dynamic Targeting via Cortical Capture of Microtubules. Develop-mental Cell 12:320-322. Lewinski MK, Yamashita M, Emerman M, Ciuffi A, Marshall H, Crawford G, Collins F, Shinn P, Leipzig J, Hannen-halli S, Berry CC, Ecker JR, Bushman FD. (2006) Retroviral DNA integration: viral and cellular determinants of tar-get-site selection. PLoS Pathog. 2:e60. Epub 2006 Jun 23. PMID: 16789841 Lin DI, Barbash O, Kumar KG, Weber JD, Harper JW, Klein-Szanto AJ, Rustgi A, Fuchs SY, Diehl JA. (2006) Phos-phorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex. Mol Cell. 24:355-66. Lin SW, Cun AS, Harris-McCoy K, Ertl HC. (2007) Intramuscular rather than oral administration of replication-defective adenoviral vaccine vector induces specific CD8+ T cell responses in the gut. Vaccine. 25:2187-93. PMID: 17229501 Little SC, Mullins MC. (2006) Extracellular modulation of BMP activity in patterning the dorsoventral axis. Birth Defects Res C Embryo Today. 78:224-42. Luo Y, High FA, Epstein JA, Radice GL. (2006) N-cadherin is required for neural crest remodeling of the cardiac out-flow tract. Dev Biol. 299:517-28.Multiple Levels. J Virol 81:7189-99. Epub 2007 Apr 25



McCoy K, Tatsis N, Korioth-Schmitz B, Lasaro MO, Hensley SE, Shih-Wen L, Li Y, Giles-Davis W, Cun A, Zhou D, Xiang Z, Letvin NL, Ertl HC. (2007) The effect of pre-existing immunity to antigens of adenovirus of the human sero-type 5 on immune responses of nonhuman primates to vaccine regimens based on human or chimpanzee-derived ade-novirus vectors. J Virol. PMID: 17428852 O’Donnell LA, Agrawal A, Jordan-Sciutto K, Dichter MA, Lynch DR and Kolson DL. (2006). HIV-induced neurotox-icity: roles for the N-methyl-D-aspartate receptor subtypes 2A and 2B, and the calcium activated protease calpain by a cerebrospinal fluid-derived HIV-1 strain J. Neurosci. 26: 981-990. O’Donnell LA, Agrawal A, Sabnekar P, Dichter MA, Lynch DR and Kolson DL. (2007). Apelin, an endogenous neu-ronal peptide, protects hippocampal neurons against excitotoxic injury. J. Neurochem. (in press). Pan, Y., K. D. Mansfield, C. Bertozzi, V. Rudenko, D. A. Chan, A. J. Giaccia, and M. C. Simon (2007) Multiple factors affecting cellular redox status and energy metabolism modulate HIF prolyl hydroxylase activities in vivo and in vi-tro. Mol. Cell. Biol. 27:912-925. Rankin EB, Biju MP, Liu Q, Unger TL, Rha J, Johnson RS, Simon MC, Keith B, Haase VH. (2007) Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo. J Clin Invest. 117:1068-77. Robertson SE, Setty SR, Sitaram A, Marks MS, Lewis RE and Chou MM.(2006) Extracellular signal-regulated kinase regulates clathrin-independent endosomal trafficking. Mol. Biol. Cell 17: 645-657. Roth-Cross, J.K., L. Martinez-Sobrido, E.P. Scott, A. Garcia-Sastre, S.R. Weiss. (2007) Inhibition of the IFN-Alpha/Beta Response by Mouse Hepatitis Virus (MHV) at Sackett SD, Fulmer JT, Friedman JR, Kaestner KH (2007) Foxl1-Cre BAC Transgenic Mice: A new tool for gene ab-lation in the gastrointestinal mesenchyme. Genesis. In press Sekiguchi, D., Yunk, L., Gary, D., Charan, D., Srivastava, B., Allman, D., Weigert, M. and E. Luning Prak (2006) De-velopment and Selection of Edited B cells in B6.56R Mice. J. Immunol 176: 6879-6887.

CAMB News Letter , Summer


Small C, Barro M, Brown TL, Patton JT. (2006) Genome heterogeneity of SA11 rotavirus due to reassortment with "O" agent. Virology. 2007 359:415-24. Epub Oct 23. PMID: 17059839 Steiner, A.B., Engleka, M.J., Lu, Q., Piwarzyk, E.C., Yaklichkin, S., Lefebvre, J.L., Walters, J.W., Pineda-Salgado, L., Labosky, P.A. and D.S. Kessler. (2006). FoxD3 regulation of Nodal in the Spemann organizer is essential for Xenopus dorsal mesoderm development. Development 133: 4827-4838. Strochlic, T.I., Setty, T.G., S.A., Sitaram, A., and Burd, C. G. (2007). Grd19/Snx3p functions as a cargo-specific adapter for retromer-dependent endocytic recycling. J.Cell Biol., 177:115-125. Tatsis N, Fitzgerald JC, Reyes-Sandoval A, Harris-McCoy KC, Hensley SE, Zhou D, Lin SW, Bian A, Xiang ZQ, Iparraguirre A, Lopez-Camacho C, Wherry EJ, Ertl HC. (2007) Adenoviral vectors persist in vivo and maintain acti-vated CD8+ T cells: implications for their use as vaccines. Blood. May 17; PMID: 17510320 Tang, N., F. Mack, V. H. Haase, M. C. Simon, and R. S. Johnson (2006) pVHL function is essential for endothelial ex-tracellular matrix deposition. Mol. Cell. Biol. 26:2519-30. Tatsis N, Lin SW, McCoy K, Garber DA, Feinberg MB, Ertl HCJ. (2007) Multiple Immunizations with Adenovirus and MVA vectors improve CD8+ T cell functionality and mucosal homing. (In Press, Virology) Tatsis N, McCoy K, Santra S, Lasaro MO, Lin SW, Hensley S, Zhou D, Xiang X, Li Y, Giles-Davis W, Cun A, Letvin N, Ertl HCJ. (2007) The Effect of Pre-existing Immunity to Antigens of Adenovirus of the Human Serotype 5 on Im-mune Responses of Nonhuman Primates to Vaccine Regimens Based on Human- or Chimpanzee-derived Adenovirus Vectors. J Virol. Apr 11; Turaga, VN, Massip, L., Chavez, A. Johnson, F.B. and Lebel, M. (2007). Werner Syndrome protein prevents DNA breaks upon chromatin structure alteration. Aging Cell, in press. Vakoc CR, Sachdeva MM, Wang H, Blobel GA. (2006) Profile of histone lysine methylation across transcribed mammalian chromatin. Mol Cell Biol. 26:9185-95. Viner, K.M., Girgis, N., Kwak, H., Isaacs, S.N. (2007) "B5 deficient vaccinia virus as a vaccine vector for the expression of a foreign antigen in vaccinia immune animals" Virology Vol. 36:356-63. Wang, J., Yin, L., Lazar, M. A. (2006) The Orphan Nuclear Receptor Rev-erb alpha Regulates Circadian Expression of Plasminogen Activator Inhibitor Type 1. J.Biol. Chem. 281:33842-33848. Wang, S., Taaffe, J., Parker, C., Solorzano, A., Cao, H., Garcia-Sastre, A., Lu, S. (2006). Hemagglutinin (HA) Proteins from H1 and H3 Serotypes of Influenza A Viruses Require Different Antigen Designs for the Induction of Optimal Protective Antibody Responses as Studied by Codon-Optimized HA DNA Vaccines. J. Virol. 80: 11628-11637 Wu J, O'Donnell M, Gitler AD, and PS Klein. (2007) Kermit-2/XGIPC, an IGF1R interacting protein, is required for IGF signaling in Xenopus eye development. Development 133:3651-3660. Yaklichkin, S., Steiner, A.B., Lu, Q. and D.S. Kessler. (2007). FoxD3 and Grg4 physically interact to repress transcription and induce mesoderm in Xenopus. Journal of Biological Chemistry 282: 2548-2557. Yanfeng WA, Tan C, Fagan RJ, Klein PS. (2006) Phosphorylation of frizzled-3. J Biol Chem. 281:11603-11609. Zhang, F., R. B. Hamanaka, E. Bobrovnikova-Marjon, J. D. Gordan, J. D. Weber, M. S. Dai, M. C. Simon, and J. A. Diehl (2006) Ribosomal stress couples the unfolded protein response to p53-dependent cell cycle arrest. J. Biol. Chem. 281:30036-30045.


Honors & Awards

Dr. Britton Chance, professor emeritus of biochemistry and biophysics, received the 2006 Distinguished Achievement Medal of the American Aging Association. Dr. Yongwon Choi, professor of pathology and labora-tory medicine, has received the Ho-Am Prize in Medi-cine. Dr. George Coukos, the Cèslo Ramon Garcia Associate Professor of Gynecological Oncology in the department of obstetrics and gynecology, has received the William Osler Patient Oriented Research Award. Dr. M. Fevzi Daldal, professor of biology, SAS, has been named a Fellow of the American Association for the Advancement of Science (AAAS). Dr. Helen C. Davies, professor of microbiology, and Om-budsman at the School of Medicine, has been awarded an Alpha Omega Alpha Robert J. Glaser Distinguished Teacher Award. Dr. Phyllis Dennery, professor of pediatrics and Werner and Gertrude Henle Endowed Chair in Pediatrics at CHOP, has received the Alfred Stengel Health System Champion Award. Dr. David L. Gasser, professor of genetics, is the recipi-ent of the Medical Student Government Teaching Award in Basic Science. Dr. Francisco González-Scarano, professor of microbiol-ogy and chair of the department of neurology, has been elected to the Institute of Medicine. Dr. Michael Granato, associate professor of cell and mo-lecular biology in Penn Medicine, has been awarded the Friedrich Wilhelm Bessel Research award by the Alex-ander von Humboldt Foundation of Bonn, Germany. Dr. Mark Greene, John Eckman Professor of Medical Science, was awarded the Robarts Research Institute’s 22nd annual J. Allyn Taylor International Prize in Medicine for his research in breast cancer. Dr. Haig H. Kazazian, Jr., Seymour Gray Professor of Molecular Medicine in Genetics was named a Fellows of the American Academy of Arts and Sciences.

Dr. Gary Koretzky, the Leonard Jarett Professor of Pathology and Laboratory Medicine, has received the Arthur K. Asbury Outstanding Faculty Mentor Award. Dr. Mitchell Lazar, Sylvan H. Eisman Professor of Medicine and Genetics, is the 2006 recipient of The Endocrine Society’s Edwin B. Astwood Award Lecture. Dr. Mitchell Lazar, Sylvan H. Eisman Professor of Medicine, has been elected to the Institute of Medicine. Dr. James Sparky Lok, professor of parasitology, dept of pathobiology He received the 2006 Dean’s Award for Leadership in Basic Science . Dr. Zissimos Mourelatos, assistant professor of pathol-ogy and laboratory medicine, has received the Michael S. Brown New Investigator Research Award. Dr. Jordan Orange, assistant professor of pediatrics, is the recipient of the Leonard Berwick Memorial Teach-ing Award recognizing outstanding fusion of basic sci-ence and clinical medicine. Dr. Jean-Pierre Saint-Jeannet, associate professor of developmental biology, received the 2007 Dean’s Award for Leadership in Basic Science Education. Dr. Amita Sehgal, professor of neuroscience and in-vestigator in the Howard Hughes Medical Institute, has received the Stanley N. Cohen Biomedical Re-search Award. ** Many of these listings are from the Almanc.

New CAMB Faculty We would like to welcome the following faculty that joined CAMB this year

Gustavo Aguirre, Professor of Medical Genetics and Ophthalmology Ben Black, Assistant Professor of Biochemistry and Biophysics Jean D. Boyer, Associate Research Professor of Path and Lab Medicine Tim Brazelton, Assistant Professor of Surgery George Coukos, Assistant Professor of Obstetrics and Gynecology Tom Curran, Professor of Pathology & Lab Medicine Mark Forman, Assistant Professor of Pathology & Lab Medicine Aaron Gitler, Assistant Professor of Cell and Developmental Biology Roger Greenberg, Assistant Professor of Cancer Biology, Pathology Kurt Hankenson, Assistant Professor of Animal Biology Tejvir Khurana, Associate Professor of Physiology Constantinos Koumenis, Associate Professor of Radiation Oncology Claude Krummenacher, Assistant Professor of Biochemistry Todd Lamitina, Assistant Professor of Physiology Michael Lampson, Assistant Professor of Biology Carlo Maley, Assistant Professor of Molecular and Cellular Oncogenesis Catherine Lee May, Assistant Professor of Path & Lab Medicine Kathryn Nathanson, Assistant Professor of Medicine Aimee Payne, Assistant Professor of Dermatology Diana Ramírez Bergeron, Assistant Professor of Path & Lab Medicine James Shorter, Assistant Professor of Biochemistry and Biophysics Ben Stanger, Assistant Professor of Medicine Wei Tong, Assistant Professor of Pediatrics Barry Ziober, Assistant Professor of Otorhinolaryngology



Future Newsletters

If you have announcements that you would like to include, please contact Meagan Schofer, [email protected]

We want to thank Justin DiAngelo for his work on the CAMB Executive com-mittee. His input has been greatly ap-preciated. His two year term is over , so we are looking for a new student representative.

To volunteer, you should have passed your prelim and plan to be here ap-proximately two more years. An ideal candidate would be a rising 3rd or 4th year student.

The committee meets once a month, usually on the third Monday of the month. If you are interested in serving as a student representative to the com-mittee please contact Meagan Schofer at [email protected]

Student Members of the CAMB Executive Committee

Congratulations to

Steven Saenz

for receiving a National Research Service

Awards for Individual Predoctoral Fellowship

NRSA

Back Row (R to L): Anthony Pajero, Jenn Levy, Michele Hickey, Jason Skinner, Sagar Kudchodkar, Christa Heyward. Front Row (R to L): Nick Sicilian, Katie Wharry, David Garbe, Laura Conlin Not Pictured: Beth Burke, Sheri Hanna, Yasuhiko Irie, Earl Stoddard

CAMB Raiders 2006

Births

Congratulations to

David Garbe recent CAMB Graduate

On the birth of his daughter Emily Garbe

university of pennsylvania c a m b news from the · university of pennsylvania summer 2007 ... and...

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