University of Groningen

New insights in methodology of screening for cervical cancerWang, Rong

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Publication date:2015

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Citation for published version (APA):Wang, R. (2015). New insights in methodology of screening for cervical cancer: Nieuwe inzichten in demethodologie van baarmoederhalskanker screening. University of Groningen.

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Curriculum Vitae

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Curriculum Vitae

Curriculum Vitae

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Curriculum Vitae

Rong Wang was born on August 25th, 1977 in Tianjin, a

coastal city in northern China. After graduation from the

Tianjin No.14 high school, she was registered in Tianjin

Agriculture College in 1996, where she obtained her

bachelor degree in 2000. By a cooperation project on

Rare earth (Lanthanum, Cerium) inhibiting cancer cells

growth, invasion and metastasis related to matrix

metalloproteinases, she started her job at the Department

of Laboratory Medicine in Tianjin Medical University. In

2003, she pursued her master degree study supervised by Professor Yunde Liu on

the same project. During her study, she became a formal teacher in that department,

who mainly engaged in the teaching of Clinical Microbiology and Parasitology. After

she obtained her master degree in Clinical Laboratory diagnosis from Tianjin Medical

University in 2006, her research transferred to the microbe in the urinary and human

disease, especially on the clinical detection of Mycoplasma and Ureaplasma and their

epidemiology in China with the guidance of Professor Shangwei Wu.

In September 2010, she started her PhD project on Medical Microbiology under the

supervision of Professor Wu. In June 2011, she was selected as a PhD student of

Groningen University. In April 2012, she started at the Department of Gynecology and

Oncology, focusing on the identification of DNA methylation biomarkers to improve

cervical cancer screening. The results of the PhD research are presented in this

thesis. Hereafter, she intends to pursue her academic research on the translational

research of clinical diagnostic biomarkers in the coming future.

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Acknowledgements

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Acknowledgements

Just as the DNA has double strands, without the well-functioning of each base pair,

there will never be a good quality of gene. So everyone knows how important a good

team is! Science is a process to look for questions and answers. Therefore, if there

are some achievements in the thesis, that’s because of our strong Questions and

Answers Team (Q&A Team). I would like to express my deep and sincere gratitude to

all of those who contributed in different ways.

First and foremost, I would like to express my sincerely gratitude to my promotor Prof.

dr. A.G.J. van der Zee. Dear Ate, you guided me with a leading question which is,

“What should I do?” in a project. Thank you for your gentle guidance, continuous

encouragement, creative ideas and invaluable suggestions in each monthly thesis

meeting and the writing of this thesis as well, which have inspired me throughout the

whole course of this project. Thanks for help me to realize my original goal

“Collaboration”. Although it isn’t initiated by me currently, I was very happy when I

heard that the first place you came in China is Tianjin, my hometown. I am so

impressed by your good surgeon technique and presentation skills after I met you in

Tianjin. I wish you could spend more time in Tianjin next time so that I would have an

opportunity to learn more from you.

Second, my sincere gratitude also goes to my other promotor, Prof. dr. E. Shuuring.

Dear Ed, you pushed me forward with your rationality and logic for science. Thank you

for always reminding me the question which is, “Why do you do that?” which stimulate

my thoughts, and make myself understood my research more deeply and clearly. With

your guidance, my research became more professional. Moreover, thank you for your

great efforts for the papers and thesis. Your detailed comments and careful

consideration of my writings has contributed towards completion of this thesis.

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Third, I would like to express my appreciation from the bottom of my heart to my

co-promotor and daily supervisor dr. G.B.A. Wisman. Dear Bea, you are indeed my

“SOS”, thank you for being available in the time of need and guided me “how to do”

things when they became beyond my capacity. Starting from the opening of my

research on DNA methylation, you have always been patient even to answer my

simple and stupid questions sometimes, providing detailed instructions on the

experiments and data analysis of my research and revising my presentations and

reports and continuously to improve my thesis work.

Next, thanks to my teammate Roland van Leeuwen, a very passionate and energetic

young man, who always instructed me “where to do” my experiments. Thanks for your

great effort on my tests and experiments. Your highly efficient, quick feedback, serious

and active communications and answers helped me to overcome lots of difficulties in

my work. I wish you great success on your doctoral study. Thank you Aniek Boers, a

girl who always told me “which samples can be used”. Thanks for your contribution in

the thesis, especially for the clinical part.

Looking back, I really enjoyed the small group meetings once in every two weeks with

you all, especially during the stage of marker identification and development of the

papers and thesis. Although some heating disputation, this enables me to understand

the research and project more deeply and completely.

I am also grateful to my Chinese supervisor, Prof. dr. Shangwei Wu. I appreciated you

for giving me a chance to enter your research. You broadened my horizon, inspired,

supported and encouraged me to realize my long awaited dream to study abroad.

Thanks for your strict and kind guidance in the early days of my research, those are

always in my mind. Thank you for your rich input editing the HPV paper. But I know, if I

want to follow your way to achieve more success, I still have a long way to go and

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work hard in the future.

My sincere gratitude also goes to the members of the reading committee: Prof. dr.

P.J.F. Snijders, Prof. dr. L.F.A.G. Massuger and Prof. dr. H.W. Nijman for the intensive

reading, evaluating and assessing of my thesis.

I owe my sincere thanks to all kinds of our Q&A groups. Thanks for our methylation

group members, Tushar Tomar, Martijn Clausen and Gert Jan Meersma. All the

discussions, advices, ideas and experiences from you helped me a lot. It is

unforgettable for the happy time we “seized” the PyroMark Q24. Thanks for

Gynecology and Oncology group, Prof. dr. Steven de Jong, Harry Klip, Nicolette

Alkema, Jolanda Visser, Roelien Meijering, Neeltje Kooi, Joost Caumanns, Marco de

Bruyn, Phuong Le, Ximena Rosas Plaza, Annechien Plat, Gerke Ariaans and Gerda

de Vries, I enjoyed staying with you all not only in the discussion but also in the time

we go out for dinner, car racing and relaxation. Additionally, I would like to thanks to

Steven for giving me a constructive ideas always on my presentation. Thanks to Harry

for the sample collection.

Like people not only have skeleton, but also have more well-developed muscle and fat

to make us look beautiful. In addition to the Q&A team, my warmest thanks also go to

my teachers, classmates, friends, roommates, colleagues and those who gave me the

opportunity, walk alongside with me, everlasting support me since my beginning.

First of all, I’d like thank the people who help me to achieve the chance to go to UMCG,

Groningen, the Netherlands. I would like to thank Prof. dr. S. Poppema for all of your

efforts to Chinese students’ study in the Netherlands, it is a beautiful memory when I

conducted my first interview with you in China. Thank Prof. dr. A.J. Moshage for

helping me to both come to Groningen and seek for the research group suitable for

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development. Thank Prof. dr. J.C. Wilschut and Prof. dr. C.A.H.H. Daemen for giving

me the first offer and initial assistance.

I greatly thank for all my heart to my family, for the invaluable care and attention.

Thank you my parent for gave me the freedom to choose my career and my life.

Thanks my young brother for the full responsibility to care the family while I was

studying. Thanks my uncles for your all too much hard work and endless support to

my study as well as care to my daily life all the time. Thanks my aunts for your

kindness and toleration. Thanks my dear cousins for your accompanies with me and

shared joy and sorrow.

My warmest thanks also goes to my lovely roommates, Urszula Domanska, Anton

Terwisscha van Scheltinga, Birgit Weyhenmeyer, Roelien Meijering and Pepijn

Schoonen. I will never forget the memorable time we had together and the precious

birthday dinner and gifts. Thanks Birgit, you always try to keep me not feeling alone

and encourage me to participate in various activities. Thanks Roelien and Pepijn, for

providing me a quiet space during the writing of my thesis. It was with a great pleasure

the moment when I invited you all to experience the Chinese food which also

beneficial for me to improve my cooking technics. Hope I will see you all again in

China in the future.

Thanks all my colleagues of M.O.L lab, the cherish and unforgettable memories in my

lifetime are those joy share with you all in all kinds of traditional activities, parties,

Lab-day, sushi and dumpling dinner, Sinterklaas, Christmas breakfast, birthday

cake…In addition, thanks to Hetty Timmer-Bosscha and Coby Meijer, for your

guidance and help for the lab manage, instrument usage, and reagent order. Thanks

to my neighbors: Hilde Nijhuis, Milind Pore, Anne Margriet Heijink, who always lend

your keys to me.

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Thank colleagues from the Department of Pathology. Thanks to all colleagues of DNA

lab for your various instructions and help as well as all kinds of interesting chats in my

experiments. Thanks Lorian Slagter-Menkema for your technical guidance for the

LightCycler 480 experiments. Thanks Lydia Visser for your delicious evening

receptions and chocolate cakes elaborately prepared ever. I will remember that sweet

taste forever. Thanks colleagues in the office of Zheng and Rui for your tolerance and

understanding upon my “daily report”.

Special thanks to my dear friends in the Netherlands: Liangzheng, Wurui Zhaoyingru,

Wanghao and Pieter-Jan, Xie Xueqian, Yanxiaomei, Zhoukai, Caojunjun, Songjuan,

Wangcuifeng, Lijun, Chencheng and Libenhui, Hanbing, Liranran Liyisi Liuyuxuan

Hanjing, and Luanzhilin, with all your help, lots of difficulties became easy, tears shift

to laugh, especially for moving each time. I appreciate Yingru, Xiaomei's generously

for my daily necessities making my stuffs always rich enough for parties. Thanks to

Hao and Peter's enthusiasm and help. It seems that we always have endless words

with Hao. Looking forward to meet all your family in China. Thanks to Xueqian both for

the help of my paper writing and lots of valuable suggestions. In addition, thank you dr.

Qu Ning and Ren Yijin, both of you try your best to set up the collaboration between

the Netherlands and China. 2015 is the 30-year anniversary of the establishment of

friendship of Groningen and Tianjin. Best wishes to your cooperative projects proceed

smoothly this year and in the future. Looking forward to our future collaboration.

Thanks for the help of my long-lasting friends in China, you assisted me to deal with a

lot of issues during the past three years. Thanks for the everlasting supporting from

Department of Laboratory Medicine in Tianjin medical university.

My sincerest gratitude goes to my paranymphs again, Roland van Leeuwen, Pepijn

Schoonen and Rea Wu, many thanks for all your generous support and contribution

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on my PhD defense. I couldn’t imagine without your help, how can I come to the

satisfactory end. Dear Rea, I indeed depend on you, I enjoy all the time I share with

you, shopping, weekend dinner, travel…all these will be cherished in my mind and my

heart.

The last but not the least, thanks the person who hurts me careless. Without the pain

of tear, how us can know the true happiness. I will try my best to find and cherish a

better tomorrow.

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