universal eye screening of infants at birth?...universal eye screening of infants at birth? pilot...

39
Universal Eye Screening of Infants at Birth? Pilot Data from the KUSP Trial (A KIDROP Initiative) Anand Vinekar , MD,FRCS Assoc. Prof & Head, Dept. of Pediatric Retina Principal Coordinator – KIDROP Narayana Nethralaya Postgraduate Institute of Ophthalmology, Bangalore

Upload: others

Post on 23-Mar-2020

2 views

Category:

Documents


0 download

TRANSCRIPT

Page 1: Universal Eye Screening of Infants at Birth?...Universal Eye Screening of Infants at Birth? Pilot Data from the KUSP Trial (A KIDROP Initiative) Anand Vinekar, MD,FRCS Assoc. Prof

Universal Eye Screening of Infants at Birth?Pilot Data from the KUSP Trial

(A KIDROP Initiative)

Anand Vinekar, MD,FRCS

Assoc. Prof & Head, Dept. of Pediatric RetinaPrincipal Coordinator – KIDROPNarayana Nethralaya Postgraduate Institute of Ophthalmology, [email protected]/KIDROP

IAPB 2012

Page 2: Universal Eye Screening of Infants at Birth?...Universal Eye Screening of Infants at Birth? Pilot Data from the KUSP Trial (A KIDROP Initiative) Anand Vinekar, MD,FRCS Assoc. Prof

No Financial Interest

Page 3: Universal Eye Screening of Infants at Birth?...Universal Eye Screening of Infants at Birth? Pilot Data from the KUSP Trial (A KIDROP Initiative) Anand Vinekar, MD,FRCS Assoc. Prof

Recap of the KIDROP initiative

Page 4: Universal Eye Screening of Infants at Birth?...Universal Eye Screening of Infants at Birth? Pilot Data from the KUSP Trial (A KIDROP Initiative) Anand Vinekar, MD,FRCS Assoc. Prof

Retinopathy of Prematurity – India’s ‘epidemic’ problem

ROP Epidemic: Leading cause of infant blindness

2 million at risk.

47% incidence, 10% blindness

< 20 ROP specialists

Screening services limited

Page 5: Universal Eye Screening of Infants at Birth?...Universal Eye Screening of Infants at Birth? Pilot Data from the KUSP Trial (A KIDROP Initiative) Anand Vinekar, MD,FRCS Assoc. Prof

Narayana Nethralaya Initiative

KIDROP’s Triple T Strategy

• Tele- ROP

• Train peripheral ophthalmologists

(ROP fellowship)

• Talking to and Training pediatricians & gynecologists

Page 6: Universal Eye Screening of Infants at Birth?...Universal Eye Screening of Infants at Birth? Pilot Data from the KUSP Trial (A KIDROP Initiative) Anand Vinekar, MD,FRCS Assoc. Prof

Narayana NethralayaKIDROP Trial

(Karnataka Internet Assisted Diagnosis of ROP)

2007 to date

Other States:MaharashtraGujaratRajasthan

Page 7: Universal Eye Screening of Infants at Birth?...Universal Eye Screening of Infants at Birth? Pilot Data from the KUSP Trial (A KIDROP Initiative) Anand Vinekar, MD,FRCS Assoc. Prof

Karnataka coverage

area

18 districts

74 hospitals

3 Independent

teams

Day Zone 1 Zone 2 (NK) Zone 3 (CK)

Mon Mandya,Mysore,

Chamrajnagar

Raichur Davangere

Tue BangaloreBBMP

Gulbarga Chitradurga

Wed Tumkur distHosur (TN)

Bidar Bellary

Thu Kolar Bijapur Haveri

Fri TumkurPavagada

Bagalkot Dharwad

Sat Bangalore Urban

Koppal Gadag

Page 8: Universal Eye Screening of Infants at Birth?...Universal Eye Screening of Infants at Birth? Pilot Data from the KUSP Trial (A KIDROP Initiative) Anand Vinekar, MD,FRCS Assoc. Prof

VS

Page 9: Universal Eye Screening of Infants at Birth?...Universal Eye Screening of Infants at Birth? Pilot Data from the KUSP Trial (A KIDROP Initiative) Anand Vinekar, MD,FRCS Assoc. Prof
Page 10: Universal Eye Screening of Infants at Birth?...Universal Eye Screening of Infants at Birth? Pilot Data from the KUSP Trial (A KIDROP Initiative) Anand Vinekar, MD,FRCS Assoc. Prof

First PPP in Infant Blindness in India - ROP

2.3 Crores (2009-2012)

Innovative Initiative by Govt. of Karnataka

12 districts in Karnataka – North and Central zones

Page 11: Universal Eye Screening of Infants at Birth?...Universal Eye Screening of Infants at Birth? Pilot Data from the KUSP Trial (A KIDROP Initiative) Anand Vinekar, MD,FRCS Assoc. Prof

• Training; Ophthalmologists & OA

• “Reading Site”

• Treatment

• Research & Advocacy

• Funding for Camera & Laser

• Logistics : Support: Mobilization of the infants – screening and treatment

• Advocacy & Health Promotion

Page 12: Universal Eye Screening of Infants at Birth?...Universal Eye Screening of Infants at Birth? Pilot Data from the KUSP Trial (A KIDROP Initiative) Anand Vinekar, MD,FRCS Assoc. Prof

TRAINING @ KIDROP

Page 13: Universal Eye Screening of Infants at Birth?...Universal Eye Screening of Infants at Birth? Pilot Data from the KUSP Trial (A KIDROP Initiative) Anand Vinekar, MD,FRCS Assoc. Prof
Page 14: Universal Eye Screening of Infants at Birth?...Universal Eye Screening of Infants at Birth? Pilot Data from the KUSP Trial (A KIDROP Initiative) Anand Vinekar, MD,FRCS Assoc. Prof

Laser treatment & patient counseling in the Rural OutreachTREATMENT AT THE OUTREACH

Page 15: Universal Eye Screening of Infants at Birth?...Universal Eye Screening of Infants at Birth? Pilot Data from the KUSP Trial (A KIDROP Initiative) Anand Vinekar, MD,FRCS Assoc. Prof
Page 16: Universal Eye Screening of Infants at Birth?...Universal Eye Screening of Infants at Birth? Pilot Data from the KUSP Trial (A KIDROP Initiative) Anand Vinekar, MD,FRCS Assoc. Prof

KIDROP

• 2008 : NN Initiative• 2009 MOU with NRHM Karnataka• 2010 : Training• 2011 (to date) Implementation

• Totally : 23578 sessions• 18 districts• 614 laser procedures

• Trained in Pune• Trained in Ahmedabad• Training (Sep 2012) Jaipur• MOU with Kerala• Expansion plan with NRHM, Govt of India

Page 17: Universal Eye Screening of Infants at Birth?...Universal Eye Screening of Infants at Birth? Pilot Data from the KUSP Trial (A KIDROP Initiative) Anand Vinekar, MD,FRCS Assoc. Prof

Look What Else We Found! Clinical entities serendipitously detected on Retcam imaging

during routine ROP screening

To be presented at the World ROP Congress, Shanghai October 14-16th, 2012

Page 18: Universal Eye Screening of Infants at Birth?...Universal Eye Screening of Infants at Birth? Pilot Data from the KUSP Trial (A KIDROP Initiative) Anand Vinekar, MD,FRCS Assoc. Prof

Aim

• To report the spectrum of anterior and posterior segment diagnoses that were detected serendipitously during routine Retinopathy of Prematurity (ROP) screening in a one-year period.

Page 19: Universal Eye Screening of Infants at Birth?...Universal Eye Screening of Infants at Birth? Pilot Data from the KUSP Trial (A KIDROP Initiative) Anand Vinekar, MD,FRCS Assoc. Prof

Methods

• 2011 : Retrospective• All infants undergoing ROP screening (< 2000

grams and / or < 34 weeks gestation age)

• Retcam imaging – (Anterior segment without lens and fundus with 130 degree lens)

• First session between 2 – 4 weeks of life• Minimum 7 images per eye (Modified PHOTO-ROP)

Page 20: Universal Eye Screening of Infants at Birth?...Universal Eye Screening of Infants at Birth? Pilot Data from the KUSP Trial (A KIDROP Initiative) Anand Vinekar, MD,FRCS Assoc. Prof

Results

• 1450 infants

• 106 infants (7.3%) with “other diagnoses”

Page 21: Universal Eye Screening of Infants at Birth?...Universal Eye Screening of Infants at Birth? Pilot Data from the KUSP Trial (A KIDROP Initiative) Anand Vinekar, MD,FRCS Assoc. Prof

Distribution of diagnoses

0

1

2

3

4

5

6

7

8

9

10

Page 22: Universal Eye Screening of Infants at Birth?...Universal Eye Screening of Infants at Birth? Pilot Data from the KUSP Trial (A KIDROP Initiative) Anand Vinekar, MD,FRCS Assoc. Prof

Anterior Segment Diagnoses

Page 23: Universal Eye Screening of Infants at Birth?...Universal Eye Screening of Infants at Birth? Pilot Data from the KUSP Trial (A KIDROP Initiative) Anand Vinekar, MD,FRCS Assoc. Prof

45% of anterior diagnoses were congenital / developmental cataracts

Page 24: Universal Eye Screening of Infants at Birth?...Universal Eye Screening of Infants at Birth? Pilot Data from the KUSP Trial (A KIDROP Initiative) Anand Vinekar, MD,FRCS Assoc. Prof

Posterior Segment Diagnoses

Page 25: Universal Eye Screening of Infants at Birth?...Universal Eye Screening of Infants at Birth? Pilot Data from the KUSP Trial (A KIDROP Initiative) Anand Vinekar, MD,FRCS Assoc. Prof

Cherry red spots OU

History of Consanguinity

STORAGE DISORDER

Page 26: Universal Eye Screening of Infants at Birth?...Universal Eye Screening of Infants at Birth? Pilot Data from the KUSP Trial (A KIDROP Initiative) Anand Vinekar, MD,FRCS Assoc. Prof

Screened for ROP

(BW 1450 grams, 33 weeks)

Suspected case of birth trauma

Page 27: Universal Eye Screening of Infants at Birth?...Universal Eye Screening of Infants at Birth? Pilot Data from the KUSP Trial (A KIDROP Initiative) Anand Vinekar, MD,FRCS Assoc. Prof

Uveitis Related Diagnoses (14 cases)

0 1 2 3 4 5 6 7 8 9 10

Page 28: Universal Eye Screening of Infants at Birth?...Universal Eye Screening of Infants at Birth? Pilot Data from the KUSP Trial (A KIDROP Initiative) Anand Vinekar, MD,FRCS Assoc. Prof
Page 29: Universal Eye Screening of Infants at Birth?...Universal Eye Screening of Infants at Birth? Pilot Data from the KUSP Trial (A KIDROP Initiative) Anand Vinekar, MD,FRCS Assoc. Prof

Fungal hyphae grown in urine Perinephric abscess draining into the pelvi-calayceal system

J AAPOS 2011;15(1):96-97.

Page 30: Universal Eye Screening of Infants at Birth?...Universal Eye Screening of Infants at Birth? Pilot Data from the KUSP Trial (A KIDROP Initiative) Anand Vinekar, MD,FRCS Assoc. Prof

Serendipitous pick up ofRetinoblastoma

Page 31: Universal Eye Screening of Infants at Birth?...Universal Eye Screening of Infants at Birth? Pilot Data from the KUSP Trial (A KIDROP Initiative) Anand Vinekar, MD,FRCS Assoc. Prof

Karnataka Universal Screening Programme

KUSP

Page 32: Universal Eye Screening of Infants at Birth?...Universal Eye Screening of Infants at Birth? Pilot Data from the KUSP Trial (A KIDROP Initiative) Anand Vinekar, MD,FRCS Assoc. Prof

KUSP Pilot

• Government Hospital• All babies delivered• Sample size : 1000

• One screening within 5 days of life• Standard protocol of imaging

Page 33: Universal Eye Screening of Infants at Birth?...Universal Eye Screening of Infants at Birth? Pilot Data from the KUSP Trial (A KIDROP Initiative) Anand Vinekar, MD,FRCS Assoc. Prof

Front Back

Page 34: Universal Eye Screening of Infants at Birth?...Universal Eye Screening of Infants at Birth? Pilot Data from the KUSP Trial (A KIDROP Initiative) Anand Vinekar, MD,FRCS Assoc. Prof

Pilot results

• 256 babies

• 16 with findings (6.25%)

• Hemorrhages

• “Retinitis”

Page 35: Universal Eye Screening of Infants at Birth?...Universal Eye Screening of Infants at Birth? Pilot Data from the KUSP Trial (A KIDROP Initiative) Anand Vinekar, MD,FRCS Assoc. Prof
Page 36: Universal Eye Screening of Infants at Birth?...Universal Eye Screening of Infants at Birth? Pilot Data from the KUSP Trial (A KIDROP Initiative) Anand Vinekar, MD,FRCS Assoc. Prof

“Opportunistic counseling” Good Eye Practice – Health education to

the parents

Using Digital images to sensitize mothers, especially for ROP

Page 37: Universal Eye Screening of Infants at Birth?...Universal Eye Screening of Infants at Birth? Pilot Data from the KUSP Trial (A KIDROP Initiative) Anand Vinekar, MD,FRCS Assoc. Prof

KUSP : Is it a good idea?

• Time will tell

• Cost-utility to be worked out

• Long term analysis is required

• Looks promising !

Page 38: Universal Eye Screening of Infants at Birth?...Universal Eye Screening of Infants at Birth? Pilot Data from the KUSP Trial (A KIDROP Initiative) Anand Vinekar, MD,FRCS Assoc. Prof

“Light of the Eyes”Movie on KIDROP by NRHM : May 2012

Page 39: Universal Eye Screening of Infants at Birth?...Universal Eye Screening of Infants at Birth? Pilot Data from the KUSP Trial (A KIDROP Initiative) Anand Vinekar, MD,FRCS Assoc. Prof

Working towards a world without ROP

blindness** Video on YouTube

THANK YOU

Follow the KIDROP Program on FACEBOOK

www.facebook.com/KIDROP