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Understanding FMD viral ecology and landscape epidemiology toward control and eradication
FMD in India
ICAR- PROJECT DIRECTORATE ON FOOT AND MOUTH DISEASE
Institute of FMD
FAO Regional Leading Diagnostic Laboratory for SAARC INDIAN COUNCIL OF AGRICULTURAL RESEARCH
Mukteswar- 263 138, Uttarakhand, India
OIE/FAO Global Foot and Mouth Disease
Reference Laboratories Network Regional Centre- India
FAO Reference Centre for Foot and Mouth Disease
Rajeev Ranjan, Biswal Jitendra Kumar , Mohapatra Jajati Keshari, Sharma Gaurav Kumar, Rout Manoranjan, Subramaniam Saravanan, Dash Bana Bihari, Sharma Ajay Kumar, Rodriguez Luis, Arzt Jonathan & Pattnaik Bramhadev [email protected]
ICAR-Project Directorate on FMD IVRI Campus, Mukteswar-263138
New Delhi
ICAR-Project Directorate on FMD IVRI Campus, Mukteswar-263138
ICAR-Project Directorate on FMD IVRI Campus, Mukteswar-263138
Organiza(onal set up Directorate of FMD
CENTRAL LABORATORY, Mukteshwar
Interna(onal Center for FMD
Bhubaneswar
• NRC on Yak, Dirang • NRC on Mithun, Nagaland
ICAR-Project Directorate on FMD IVRI Campus, Mukteswar-263138
Susceptible Livestock population in India
CaEle 190.90 Buffalo 108.70 Sheep 65.06 Goat 135.17 Pig 10.29 Yak 0.077 Mithun 0.298 Camel 0.40 -‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐ Total 510.89 Million ########################################################### India has size of >3.2 million sq km Administra(ve units 29 states (Further consist of 666Districts and >6,00,000 villages are there in the country.
Source: DAHDF, GOI, 2012
ICAR-Project Directorate on FMD IVRI Campus, Mukteswar-263138
79%
7% 14%
Type O Type A Type Asia1
Last, type C incidence in 1995
Present National Scenario
ICAR-Project Directorate on FMD IVRI Campus, Mukteswar-263138
• Fi_y four (54) districts in which control programme started in 2003-‐04 are marked red.
• One sixty seven (167) districts in which the control programme started in 2010-‐11 are marked green.
• FMDCP implemented in 2013-‐14 . • FMDCP implemented in 2015-‐ 16 • Not covered under FMDCP
Foot & Mouth Disease Control Programme (FMDCP)
Understanding FMD Viral Ecology and Landscape Epidemiology toward Control
and Eradica(on [ICAR-‐PDFMD & ARS (USDA) Collabora(on]
ICAR-Project Directorate on FMD IVRI Campus, Mukteswar-263138
0
20
40
60
80
100
1 2
3 4
5
40 (18% *)
82 (37% *)
52 (23% *)
34 (15% *)
14 (6% *)
FMD cases
Weeks
Number of reported cases per week
* Out of 222
Study site- Dairy premise, Central India
1st case reported- 24th December, 2013 The last clinical case- 31st Jan, 2014
ICAR-Project Directorate on FMD IVRI Campus, Mukteswar-263138
ICAR-Project Directorate on FMD IVRI Campus, Mukteswar-263138
0
50
100
150
3M 5M 7M 10M 13M
% Posi(ve
Months post outbreak
Clinically affected caEle
% NSP Posi@ve
% Genome Posi@ve
% Isola@on Posi@ve
0
20
40
60
80
100
120
3M 5M 7M 10M 13M
% P
ositi
ve
Months post outbreak
Asymtomatic In-contact Cattle
% NSP Posi@ve
% Genome Posi@ve
% Isola@on Posi@ve
ICAR-Project Directorate on FMD IVRI Campus, Mukteswar-263138
0
20
40
60
80
100
120
3M 5M 7M 10M 13M
% P
ositi
ve
Months post outbreak
Clinically affected buffalo
% NSP Posi@ve
% Genome Posi@ve
% Isola@on Posi@ve
0
20
40
60
80
100
120
3M 5M 7M 10M 13M
% P
ositi
ve
Months post outbreak
Asymptomatic In-contact buffalo
% NSP Posi@ve
% Genome Pos@ve
% Isola@on Posi@ve
ICAR-Project Directorate on FMD IVRI Campus, Mukteswar-263138
0
20
40
60
80
100
120
3M 5M 7M 10M 13M
% P
ositi
ve
Months post outbreak
% NSP Posi@ve
% Genome Posi@ve
% Isola@on Posi@ve
Overall cattle and buffalo
• Genetic and antigenic characterization of the isolates obtained from OPF of persistently infected animals is in progress.
ICAR-Project Directorate on FMD IVRI Campus, Mukteswar-263138
Conclusions: • In present study, NSP-‐ Ab (ter is lower in buffalo than caOle.
• The NSP-‐ Ab posi(ve propor(on was consistently lower for asymptoma@c category compared to clinical recovered animals.
• Not much difference in the genome detec(on propor(on between clinically recovered and asymptoma@c category animals.
• Dura(on of FMD virus persistence is more in buffalo than caOle under natural condi@on.
• Virus clearing with @me in both the category of animals is evident from gradual decline in propor(on of viral genome and virus isola(on posi(ve samples and gradual decline in NSP-‐Ab (ter.
ICAR-Project Directorate on FMD IVRI Campus, Mukteswar-263138
Acknowledgements
• All the scien@fic and technical staff of ICAR-‐ PDFMD, Mukteshwar
• Indian Council of Agricultural Research, New Delhi • Staff of Dairy Farm
• Luis Rodriguez and Jonathan Arzt, PIADC, ARS, USDA • DTRA and United States Strategic Command Centre
• Maria Sterlyadkina, SAIC/TTI DTRA CLS Support
• GFRA
ICAR-Project Directorate on FMD IVRI Campus, Mukteswar-263138
Himalayan view from PDFMD, Mukteswar 15
Thanks for your kind aEen(on