under the auspices of the ebmt cellular therapy … · dr. paolo pedrazzoli policlinico san matteo...
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November 11th -13th, 2015Milano, San Raffaele Hospital
THE EBMT CELLULAR THERAPY AND IMMUNOBIOLOGY WORKING PARTYSYMPOSIUMFrom Transplantation to Gene Therapy: Cellular therapy in evolution
SCIENTIFIC PROGRAM
UNDER THE AUSPICES OF
ACKNOWLEDGEMENTS
SIESocietà Italiana di Ematologia
EBMT-CTIWP BOARDChairmanProf. Chiara BoniniVita-Salute San Raffaele University Milano, Italy
SecretaryProf. Christian ChabannonPaoli Calmettes Institute Marseille, France
LOCAL SCIENTIFIC COMMITTEEDr. Attilio BondanzaSan Raffaele Hospital Milano, Italy
Prof. Fabio CiceriVita-Salute San Raffaele University Milano, Italy
Dr. Sara MastaglioSan Raffaele Hospital Milano, Italy
Dr. Luca VagoSan Raffaele Hospital Milano, Italy
FACULTYProf. Francesco DazziKing’s College London, UK
Dr. Paolo DellabonaSan Raffaele Hospital Milano, Italy
Prof. Gianpietro DottiThe University of North Carolina Chapel Hill, USA
Prof. Hermann EinseleUniversity Hospital Würzburg, Germany
Dr. Ivana FerreroUniversità degli Studi Torino, Italy
Dr. Willem E. FibbeLeiden University Medical Center Leiden, The Netherlands
Prof. Katharina FleischhauerEssen University Hospital Essen, Germany
Dr. Maria Cristina GalliIstituto Superiore di Sanità Roma, Italy
Dr. Eliane GluckmanEurocord International Registry Hôpital Saint Louis Paris, France
Prof. Phil GreenbergUniversity of Washington Fred Hutchinson Cancer Research Center Seattle, USA
Dr. Silvia GregoriSan Raffaele Hospital Telethon Institute for Gene Therapy Milano, Italy
Dr. Michael HudecekUniversity Hospital Würzburg, Germany
Prof. Ulrike KöhlHannover Medical School (MHH) Hannover, Germany
Prof. Franco LocatelliPediatric Hospital Bambino Gesù Roma, Italy
Dr. Anna MondinoSan Raffaele Hospital Milano, Italy
Prof. Luigi NaldiniVita-Salute San Raffaele University Milano, Italy
Prof. Richard O’ReillyMemorial Sloan Kettering Cancer Center New York, USA
Dr. Paolo PedrazzoliPoliclinico San Matteo Hospital Pavia, Italy
Prof. Karl PeggsUniversity College Hospital London, UK
Dr. Jan RichterNovartis Pharma AG Basel, Switzerland
Prof. Vanderson RochaOxford University Hospitals Oxford, UK
Dr. Annalisa RuggeriEurocord International Registry Hôpital Saint Louis Paris, France
Dr. Carmen Ruiz de ElviraEBMT Central Registry Office London, UK
Prof. Jaime Sanz Caballer University Hospital La Fe Valencia, Spain
Prof. Antoine ToubertParis Diderot University Paris, France
Dr. Marcel van den BrinkMemorial Sloan Kettering Cancer Center New York, USA
Prof. Andrea VelardiUniversity of Perugia Perugia, Italy
FACULTYProf. Alessandro AiutiVita-Salute San Raffaele University Milano, Italy
Prof. Isabelle André-SchmutzInstitut Imagine – INSERM Paris, France
Dr. Manuela BattagliaSan Raffaele Hospital Milano, Italy
Dr. Maria Ester BernardoSan Raffaele Hospital Milano, Italy
Prof. Ettore BiagiMilano-Bicocca University San Gerardo Hospital Monza, Italy
Prof. Andrea BiondiMilano-Bicocca University Milano, Italy
Prof. Claudio BordignonMolMed Spa Milano, Italy
Dr. Marco BregniOspedale di Circolo Busto Arsizio (VA), Italy
Dr. Giulia CasoratiSan Raffaele HospitalMilano, Italy
Dr. Nicoletta CieriSan Raffaele Hospital Milano, Italy
Prof. Massimo ClementiVita-Salute San Raffaele University Milano, Italy
Dr. Patrizia ComoliPoliclinico San Matteo Hospital Pavia, Italy
Wednesday, November 11th 2015
14.00-17.30 The CTIWP Business meeting
18.00-19.30 Symposium Opening Lectures Chairs: C. Bonini, C. Chabannon
Immune players in BMT R. O’Reilly, USA
From bench to GMP C. Bordignon, Italy
19.30 Light buffet
Thursday, November 12th 2015
09.00 Keynote Lecture Chair: M. Clementi
Microbiome and GvHD M. van den Brink, USA
Session I Cord Blood Transplantation: current challenges Chairs: F. Locatelli, V. Rocha
09.40 Do we need to collect more CBU? J. Sanz Caballer, Spain
10.00 Immune reconstitution after CBT A. Ruggeri, France
10.20 Open questions in clinical CBT E. Gluckman, France
10.40 Keynote Lecture Chairs: M. Battaglia, S. Gregori
Cellular therapy to improve outcome of haplo-HSCT A. Velardi, Italy
11.20 Break
SCIENTIFIC PROGRAM
Session II Cellular therapy to improve transplantation outcome Chairs: M. Bregni, P. Comoli
11.40 MSCs: does source matter? M.E. Bernardo, Italy
12.00 NK cell therapy in allo-SCT C. Chabannon, France
12.20 Cellular therapy for tolerance induction: MSC vs Tregs in HSCT
F. Dazzi, UK
12.40 Cell therapy for cytomegalovirus K. Peggs, UK
13.00 Lunch break
14.00 Pathogen specific T cells H. Einsele, Germany
14.20 Alfabeta depletion in haplo-HSCT F. Locatelli, Italy
14.40 Targeting leukemia by lipid specific T cells G. Casorati, Italy
15.00 Keynote Lecture Chair: F. Locatelli Harnessing mesenchymal stromal cells for
immune modulatory treatment W. Fibbe, The Netherlands
15.40 Break
Session III The use of genetically redirected T cells:
Improving SCT or replacing SCT? Chairs: P. Dellabona, P. Pedrazzoli
16.00 Targeting AML and MM with CD44v6-CAR T cells: synergy with allo-SCT?
A. Bondanza, Italy
16.20 Targeting MM with CAR T cells M. Hudecek, Germany
16.40 CAR-T cells from lymphoid malignancies to solid tumors G. Dotti, USA
17.00 CAR expressing NK cells U. Köhl, Germany
17.20 Keynote Lecture TCR redirected T cells for myeloid leukemia P. Greenberg, USA
18.00 Round Table Cellular Therapy: improving the outcome of SCT
or replacing SCT? A. Aiuti, F. Ciceri, G. Dotti, P. Greenberg, R. O’Reilly
Friday, November 13th 2015
09.00 Keynote Lecture Chairs: A. Biondi, C. Bordignon
Lentiviral vectors and nucleases: clinical applications and future directions
L. Naldini, Italy
Session IV Regulation, harmonization and sustainability
of cellular therapy: what can we learn from SCT? Chairs: A. Aiuti, F. Ciceri
10.00 Cell therapy in Jacie standards I. Ferrero, Italy
10.20 A European Registry for cellular therapy C. Ruiz de Elvira, UK
10.40 Break
11.00 A sustainable cellular therapy approach: CAR-based CIK E. Biagi, Italy
11.20 Regulatory framework from ATMP M.C. Galli, Italy
11.40 Round Table From HSCT to cell therapy and gene therapy:
regulatory hurdles and innovative business models C. Bordignon, M.C. Galli, M. Introna, J. Richter
12.45 Lunch break
Session V Cellular Therapy and allo-SCT:
guidelines for patients’ follow-up Chairs: A. Bondanza, A. Toubert
13.40 How to improve post-transplant immunological reconstitution
I. André-Schmutz, France
14.00 Assessing lymphocyte generation by DNA rearrangement excision circles in allo-HSCT
A. Toubert, France
14.20 The concept of permissiveness in HSCT and cell therapy K. Fleischhauer, Germany
14.40 Leukemia immune editing L. Vago, Italy
15.00 Memory stem T cells in transplantation and cellular therapy
N. Cieri, Italy
15.20 Keynote Lecture Chair: C. Bonini
When allogeneic hematopoietic cell transplantation meets adoptive T cell Therapy
A. Mondino, Italy
16.00 Closing remarks
SCIENTIFIC PROGRAM