uk renal registry 9 th annual report 2006 fig 9.1 percentage of patients with serum phosphate

20
UK Renal Registry 9 th Annual Report 2006 Fig 9.1 Percentage of patients with serum phosphate <1.8 mmol/L : HD 0 10 20 30 40 50 60 70 80 90 100 Centre Percentage ofpatients U pper95% Cl % w ith phos betw een <1.8 Low er95% Cl

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Page 1: UK Renal Registry 9 th Annual Report 2006 Fig 9.1 Percentage of patients with serum phosphate

UK Renal Registry 9th Annual Report 2006

Fig 9.1 Percentage of patients with serum phosphate <1.8 mmol/L : HD

010

2030

4050

6070

8090

100

Centre

Per

cent

age

of p

atie

nts

Upper 95% Cl

% with phos between <1.8

Lower 95% Cl

Page 2: UK Renal Registry 9 th Annual Report 2006 Fig 9.1 Percentage of patients with serum phosphate

UK Renal Registry 9th Annual Report 2006

Fig 9.2 Percentage of patients with serum phosphate <1.8mmol/L : PD

0

10

20

30

40

50

60

70

80

90

100

2 W

olve

0 R

edng

2 L

eeds

0 B

Hea

rt 3

Che

lms

0 B

asld

n 3

Cov

nt 4

Lei

c 4

Car

sh 1

Oxf

ord

0 N

orw

ch 6

Dud

ley

0 C

amb

14 B

right

n 2

Shr

ew 3

Dor

set

11 M

anW

st 0

Bra

dfd

3 C

ardf

f 0

Ban

gor

3 L

Rfr

ee 2

Ips

wi

0 E

xete

r 2

Liv

rpl

12 P

orts

1 S

wan

se 0

Ste

vng

2 L

H&

Cx

5 S

then

d 0

Not

tm 1

L G

uys

6 D

erby

0 L

Kin

gs 0

Tru

ro 0

Bris

tol

1 S

heff

4 Y

ork

3 P

lym

th 6

Bel

fast

4 H

ull

2 N

ewc

6 B

QE

H 0

Pre

stn

3 G

louc

15 W

rexm

9 E

ng 7

NI

4 W

ls 9

UK

Centre

Per

cent

age

of p

atie

nts

Upper 95% Cl

% with phos <1.8

Lower 95% Cl

Page 3: UK Renal Registry 9 th Annual Report 2006 Fig 9.1 Percentage of patients with serum phosphate

UK Renal Registry 9th Annual Report 2006

Fig 9.3 Percentage with serum phosphate < 1.8mmol/L 1999 - 2005 UK

40

45

50

55

60

65

70

75

80

1999 20002001 2002 20032004 2005 19992000 2001 20022003 2004 2005

Pe

rce

nta

ge

of p

atie

nts

Upper 95% CI

% with phos < 1.8

Lower 95% CI

Haemodialysis Peritoneal Dialysis

Page 4: UK Renal Registry 9 th Annual Report 2006 Fig 9.1 Percentage of patients with serum phosphate

UK Renal Registry 9th Annual Report 2006

Fig 9.4 Median serum phosphate mmol/L: Transplant

0.6

0.7

0.8

0.9

1.0

1.1

1.2

1.3

1.4

7 D

udle

y 2

Glo

uc14

Wol

ve15

Bas

ldn

3 Y

ork

13 P

rest

n14

Car

lis 8

Red

ng17

B H

eart

28 L

Rfr

ee 6

Nor

wch

36 D

orse

t 6

Tru

ro 2

Bris

tol

8 B

radf

d26

Cov

nt16

Man

Wst

2 S

heff

4 M

iddl

br11

Hul

l17

Por

ts11

B Q

EH

7 L

Guy

s 2

Sw

anse

3 N

ewc

8 P

lym

th 5

Ips

wi

3 L

H&

Cx

8 E

xete

r20

Sth

end

7 L

Kin

gs33

Ste

vng

3 S

hrew

12 C

arsh

6 C

amb

10 A

ntrim

19 L

eic

1 S

und

5 C

ardf

f 9

Liv

rpl

3 O

xfor

d12

Not

tm28

Brig

htn

4 B

elfa

st 7

Lee

ds30

New

ry41

Tyr

one

15 E

ng12

NI

4 W

ls14

UK

Centre

Ser

um p

hosp

hate

mm

ol/L

Upper quartileMedian phosphateLower quartile

N = 12626

Page 5: UK Renal Registry 9 th Annual Report 2006 Fig 9.1 Percentage of patients with serum phosphate

UK Renal Registry 9th Annual Report 2006

Fig 9.5 Funnel plot for percentage achievement of phosphate <1.8mmol/L:

HD

Page 6: UK Renal Registry 9 th Annual Report 2006 Fig 9.1 Percentage of patients with serum phosphate

UK Renal Registry 9th Annual Report 2006

Fig 9.6 Percentage of patients with corrected calcium within 2.2 to 2.6 mmol/L : dialysis

4045

5055

6065

7075

8085

9095

100

6 L

Rfr

ee17

Wre

xm

0 N

orw

ch 2

New

ry 1

Tru

ro

4 B

Hea

rt 1

Glo

uc

6 C

arlis

2 T

yron

e

2 H

ull

0 L

Kin

gs 1

She

ff

0 R

edng

2 L

eeds

0 N

ottm

1 O

xfor

d 0

Bra

dfd

1 B

asld

n 6

Ste

vng

2 C

ovnt

10 L

Guy

s

1 D

orse

t 2

Sw

anse

29 B

right

n

2 C

helm

s 4

Yor

k

3 B

ango

r 3

Ant

rim

2 D

erby

1 P

lym

th 0

Pre

stn

1 E

xete

r 3

Lei

c

2 L

ivrp

l 0

Bris

tol

1 Ip

swi

1 W

olve

3 C

ardf

f

3 B

QE

H 3

Sth

end

6 B

elfa

st 2

Shr

ew24

Cam

b

8 C

lwyd

0 N

ewc

3 P

orts

13 D

udle

y

3 S

und

1 L

H&

Cx

2 M

iddl

br

15 M

anW

st10

Car

sh

0 U

lste

r 9

Eng

4 N

I

5 W

ls 9

UK

Centre

Pe

rce

nta

ge

of

pa

tien

ts

Upper 95% CI

% w ith Corrected calcium in ref range

Low er 95% CI

Page 7: UK Renal Registry 9 th Annual Report 2006 Fig 9.1 Percentage of patients with serum phosphate

UK Renal Registry 9th Annual Report 2006

Fig 9.7 Change in percentage of patients achieving serum corrected calcium 2.2-2.6mmol/L 1999 - 2005 UK

Page 8: UK Renal Registry 9 th Annual Report 2006 Fig 9.1 Percentage of patients with serum phosphate

UK Renal Registry 9th Annual Report 2006

Fig 9.8 Percentage of patients with corrected calcium within 2.2 to 2.6 mmol/L : transplant

40

45

50

55

60

65

70

75

80

85

90

95

100

41 T

yron

e

1 G

louc

28 L

Rfr

ee

6 L

Kin

gs

3 N

ewc

4 C

ardf

f

2 S

wan

se

7 R

edng

1 S

und

2 S

heff

7 L

Guy

s

5 D

orse

t

34 S

tevn

g

6 T

ruro

3 O

xfor

d

5 Ip

swi

10 A

ntrim

19 L

eic

28 B

right

n

41 Y

ork

6 N

orw

ch

16 B

Hea

rt

4 M

iddl

br

10 B

QE

H

17 C

ovnt

6 C

amb

9 C

arlis

5 B

elfa

st

3 L

H&

Cx

2 B

risto

l

9 L

ivrp

l

8 L

eeds

11 P

rest

n

11 P

orts

18 S

then

d

3 S

hrew

12 N

ottm

4 W

olve

3 B

radf

d

8 E

xete

r

16 M

anW

st

7 D

udle

y

11 C

arsh

30 N

ewry

6 P

lym

th

11 H

ull

8 B

asld

n

14 E

ng

12 N

I

4 W

ls

13 U

K

Centre

Per

cent

age

of p

atie

nts

Upper 95% CI% with Ca_corr in ref rangeLower 95% CI N = 12,759

Page 9: UK Renal Registry 9 th Annual Report 2006 Fig 9.1 Percentage of patients with serum phosphate

UK Renal Registry 9th Annual Report 2006

Fig 9.9 Median corrected calcium : transplant

2.102.152.202.252.302.352.402.452.502.552.602.652.70

11 H

ull

8 B

asld

n

12 N

ottm

2 B

risto

l

8 E

xete

r 2

9 L

ivrp

l

30 N

ewry

7 R

edng

41 T

yron

e

10 B

QE

H

28 B

right

n

2 S

heff

19 L

eic

7 L

Guy

s 6

L K

ings

10 A

ntrim

4 M

iddl

br

6 N

orw

ch

34 S

tevn

g

7 D

udle

y

5 Ip

swi

18 S

then

d

16 B

Hea

rt

6 P

lym

th

6 T

ruro

1 S

und

28 L

Rfr

ee

1 G

louc

3 S

hrew

5 D

orse

t

3 N

ewc

9 C

arlis

3 O

xfor

d

4 C

ardf

f

4 W

olve

11 P

orts

5 B

elfa

st

3 B

radf

d

3 L

H&

Cx

11 P

rest

n

8 L

eeds

17 C

ovnt

6 C

amb

11 C

arsh 16

41 Y

ork

14 E

ng

12 N

I

4 W

ls

13 U

K

Centre

Ser

um c

alci

um m

mol

/L

Upper quartileMedian Ca corrLower quartile

N = 12,759

Page 10: UK Renal Registry 9 th Annual Report 2006 Fig 9.1 Percentage of patients with serum phosphate

UK Renal Registry 9th Annual Report 2006

Fig 9.10 Calcium phosphate product within KDOQI ref: dialysis

3035404550556065707580859095

100

Centre

Per

cent

age

of p

atie

nts

Upper 95% CI% with Ca corr*Phos in DOQI ref rangeLower 95%CI

Page 11: UK Renal Registry 9 th Annual Report 2006 Fig 9.1 Percentage of patients with serum phosphate

UK Renal Registry 9th Annual Report 2006

Fig 9.11 Percentage of patients with calcium phosphate product in KDOQI reference range : haemodialysis

30

40

50

60

70

80

90

100

Centre

Per

cent

age

of p

atie

nts

Upper 95%CI

% with Ca corr*Phos in DOQI ref range

Lower 95% CIN = 11,989

Page 12: UK Renal Registry 9 th Annual Report 2006 Fig 9.1 Percentage of patients with serum phosphate

UK Renal Registry 9th Annual Report 2006

Fig 9.12 Percentage of patients with calcium*phosphate product in KDOQI reference range: peritoneal dialysis

30

40

50

60

70

80

90

100

Centre

Per

cent

age

of p

atie

nts

Upper 95%CI

% with Ca corr*Phos in DOQI ref range

Lower 95%Ci

N = 3,362

Page 13: UK Renal Registry 9 th Annual Report 2006 Fig 9.1 Percentage of patients with serum phosphate

UK Renal Registry 9th Annual Report 2006

Fig 9.13 Change in percentage of patients achieving serum corrected calcium X phosphate product target 1998 - 2005 UK

50

55

60

65

70

75

80

85

9019

98

1999

2000

2001

2002

2003

2004

2005

1998

1999

2000

2001

2002

2003

2004

2005

Pe

rce

nta

ge

of

pa

tien

ts

Upper 95% CI

% ca P04 < 4.4 mmol/L

Lower 95% CI

HD PD

Page 14: UK Renal Registry 9 th Annual Report 2006 Fig 9.1 Percentage of patients with serum phosphate

UK Renal Registry 9th Annual Report 2006

Fig 9.14 Median iPTH in dialysis patients

0

10

20

30

40

50

60

70

80

Centre

iPT

H p

mol

/L

Upper quartileMedian iPTHLower quartile

N = 13,007

Page 15: UK Renal Registry 9 th Annual Report 2006 Fig 9.1 Percentage of patients with serum phosphate

UK Renal Registry 9th Annual Report 2006

Fig 9.15 Percentage of patients on dialysis with iPTH < 32 pmol/L

0

10

20

30

40

50

60

70

80

90

100

Centre

Per

cent

age

of p

atie

nts

Upper 95% Cl% with IPTH <32 pmol/L

Lower 95% Cl N = 14,439

Page 16: UK Renal Registry 9 th Annual Report 2006 Fig 9.1 Percentage of patients with serum phosphate

UK Renal Registry 9th Annual Report 2006

Fig 9.16 Percentage of patients with cholesterol < 5 mmol/L: HD

404550556065707580859095

100

23 M

anW

st10

Ipsw

i14

Lee

ds 5

Red

ng24

Wre

xm 1

New

ry 6

Glo

uc18

Car

dff

0 P

rest

n33

Der

by 3

Tru

ro 6

L K

ings

3 N

ottm

12 C

arlis

11 L

Rfr

ee 2

Ant

rim 9

Bel

fast

4 B

QE

H19

Lei

c 4

Sun

d 7

L G

uys

34 C

helm

s 2

Tyr

one

8 W

olve

5 S

then

d 0

Nor

wch

7 S

heff

5 N

ewc

46 C

lwyd

8 B

risto

l37

Cam

b 0

Uls

ter

21 B

ango

r 2

Shr

ew 9

Oxf

ord

4 S

wan

se 1

L H

&C

x35

Por

ts27

Car

sh 1

Bas

ldn

8 P

lym

th 2

Mid

dlbr

13 H

ull

13 B

radf

d 8

Dor

set

5 E

xete

r15

Yor

k24

Eng

5 N

I17

Wls

23 U

K

Centre

Per

cent

age

of p

atie

nts

Upper 95% CI% with cholesterol < 5Lower 95% CI N = 10,171

Page 17: UK Renal Registry 9 th Annual Report 2006 Fig 9.1 Percentage of patients with serum phosphate

UK Renal Registry 9th Annual Report 2006

Fig 9.17 Percentage of patients with cholesterol <= 5 mmol/L: PD

30

40

50

60

70

80

90

100

0 B

ango

r

11 P

lym

th

1 S

wan

se

25 W

rexm

6 L

Rfr

ee

0 T

ruro

0 C

amb

9 G

louc

5 N

ottm

0 L

Guy

s

17 M

anW

st

2 P

rest

n

32 D

udle

y

14 L

eeds

3 B

QE

H

3 R

edng

5 B

elfa

st

8 L

eic

16 B

risto

l

28 S

heff

6 L

Kin

gs

5 Ip

swi

2 N

ewc

4 Y

ork

6 D

orse

t

13 W

olve

22 S

tevn

g

0 S

hrew

42 B

right

n

0 N

orw

ch

11 O

xfor

d

28 C

arsh

2 L

H&

Cx

2 C

ardf

f

6 B

Hea

rt

0 B

asld

n

3 B

radf

d

16 E

xete

r

24 E

ng

7 N

I

8 W

ls

22 U

K

Centre

Per

cent

age

of p

atie

nts

Upper 95%CI% with cholesterol < 5Lower 95% CI

N = 2,878

Page 18: UK Renal Registry 9 th Annual Report 2006 Fig 9.1 Percentage of patients with serum phosphate

UK Renal Registry 9th Annual Report 2006

Fig 9.18 Percentage of patients with cholesterol < 5 mmol/L: transplant

0

10

20

30

40

50

60

70

80

90

100

6 L

eeds

1 S

wan

se 5

Bra

dfd

15 S

then

d13

Man

Wst

11 Y

ork

12 C

ardf

f17

Lei

c 2

New

c16

Not

tm10

L K

ings

34 L

Rfr

ee37

Tru

ro 4

Ply

mth

37 S

tevn

g14

Pre

stn

4 B

asld

n 3

Red

ng 7

L G

uys

3 B

elfa

st44

Car

sh 5

Car

lis 6

Nor

wch

8 B

QE

H10

Wol

ve 1

Sun

d 2

L H

&C

x 7

Ips

wi

37 D

udle

y 9

Dor

set

3 S

heff

20 N

ewry

5 B

risto

l45

Ant

rim23

Oxf

ord

45 B

Hea

rt21

Mid

dlbr

26 G

louc

34 H

ull

36 P

orts

10 C

amb

8 E

xete

r41

Tyr

one

25 S

hrew

25 E

ng14

NI

10 W

ls24

UK

Centre

Per

cent

age

of p

atie

nts

Upper 95% CI% with cholesterol < 5Lower 95% CI N = 11,170

Page 19: UK Renal Registry 9 th Annual Report 2006 Fig 9.1 Percentage of patients with serum phosphate

UK Renal Registry 9th Annual Report 2006

Fig 9.19 Serum cholesterol distribution by modality 31/12/2005

Page 20: UK Renal Registry 9 th Annual Report 2006 Fig 9.1 Percentage of patients with serum phosphate

UK Renal Registry 9th Annual Report 2006

Fig 9.20 Percentage of patients with cholesterol < 5 mmol/L: HD vs PD vs

Tx 1997 - 2005