ucsf department of pharmaceutical...

11
== 4A AY Aaf 'clocrtl 1', ^, +DJ: v / flr* J .i rr:. _l bt'.j iE" -Q I L7 F4rYo\A JJI ) -'.lf r \t{f , h: oa(1 bq-- -xC,a 4Cr- = o.(:, - cr\ H = ((c.:(,) c -o( Ac/ax J : -\ 1'" PV= pf,T 4- o'(t .- L. L ''at 4- .|t t t t { ^{ /-t I d :l I !( \ J= L *> Pl*\' \*o * \t-i \" +,--*,-\* * J= '+ &* ( L4 = N =)a ltC, - O.LL 'i { { ( -{ 3 e I li -{ \ ! ;c !t .-t tl L l- T tr e' t" ] r- l- I' t- E , u {r.( / { J, I Jo i^ tl^t*\ , ""trl. J{o * : . c tx) 3 uLT L. 'r't t ( fri.lion ';ft tl** r,,.Lili!" U?

Upload: others

Post on 10-Jul-2020

0 views

Category:

Documents


0 download

TRANSCRIPT

Page 1: UCSF Department of Pharmaceutical Chemistryhuanglab.ucsf.edu/Chem241/Chm241_Pitera_PhysKin_notes.pdf · Created Date: 10/18/2013 2:45:38 PM

==

4A AY

Aaf

'clocrtl1' ,^,+DJ:v

/

flr* J

. ir r : .

_ l

bt'.j iE"-Q I L7

F4rYo\A JJI

)-'.lf

r \t{f

, h: oa(1

bq-- -xC,a 4Cr-

= o.( : , - cr \

H = ((c.:(,)c -o( Ac/ax

J : -\ 1'"

PV= pf,T

4- o'(t. - L.

L ' 'at

4-.|t

ttt{

^{/-t

Id:lI

!(

\

J= L

*> Pl*\' \*o * \t-i \"

+,--*,-\* *J= '+ &*

(

L4 = N=)a

l tC,

-O.LL

'i

{

{

(

-{

3

eIl i

-{

\

!

;c!t

.-ttl

Ll -Ttre't"]r -

l -I '

t -

E

,u

{r.(

/

{

J, I Jo

i^ tl^t*\ ,

""trl.J{o *

:

.

c tx)

3 uLT

L.' r ' tt

(

fri.lion ';ft tl**

r,,.Li l i !"U?

Page 2: UCSF Department of Pharmaceutical Chemistryhuanglab.ucsf.edu/Chem241/Chm241_Pitera_PhysKin_notes.pdf · Created Date: 10/18/2013 2:45:38 PM

L(-,Orl-SCt*v'l't ovt'

Jo-tl i - . - "4

J6o-1 ' ' '

^, ' IA{l.lx o,rf ot V

b,-i:,n; 4 a/ tt,*; ' A( -_ A t+;.J {o *) "

?, F "-'

Ac-- A$[ ' (*n

A6t t . i i '1*: n l i r f ,

\

l

IlIII I, lI

iI

1\,i

-i '\:

_t

v3

a

o3

*

tL

}

+ft

itt+-t-t

tvI

l , ,Llv

gL1 -il,

, _,Jci/s+ "

3I- it{i

}

(#).

j t-:j"

i . . i

^t \ . " : ' j ; i ., t i ,

t I

svLef:h,+'e- /bO'4, Ft"h's Isr ta'^t

3 [v".

/t" ) tttl Lboou)a .enI ii .Ii

t r6jre c(r)

q{i

t

Page 3: UCSF Department of Pharmaceutical Chemistryhuanglab.ucsf.edu/Chem241/Chm241_Pitera_PhysKin_notes.pdf · Created Date: 10/18/2013 2:45:38 PM

, , . , ,1^- ; . -"S3-/ tAJ

f . . t*, i

. .1.

br: :* - : . . a---r ,. L1 . - . 's t >.Lf -t ' f

.J!

, ) '

A

il

I

ir

I

1

.)

\ | , , t ] - n \J, . i ( { . , }i :St ! l \ " ' ;

bC' ,

o , \ -il..

l,o;5( -*:'" r '\r^ t*l*' r

Dac A

fi-'-'.. ...'' i-l *l' }.. " :r'l { '

f P':t{u t =t^0. : nUil t4; - ! -gt ' r t \ i '> \ . t \ { ' i - \ - ' : i '

-1r ' - i1 ). \ -

-c(r) 'Arf I4 - i: ' \

- rC,\ L ? - i ' - ) ': r - : ' ' r l

cr

. i -

+b.\

r . \ \ -- F. ; , /, i

1...,\'I*7"",., lqA i *

*S"{'-'rv''''6

, ,Y - 'E ' - - h

&r ' { ' ) i

' { * Al,

\l/

U

&1";F0:

".t; A) V,J : '

: \ts'"' , sh1t - -LK *

f+".""\(x) : * t '

Page 4: UCSF Department of Pharmaceutical Chemistryhuanglab.ucsf.edu/Chem241/Chm241_Pitera_PhysKin_notes.pdf · Created Date: 10/18/2013 2:45:38 PM

.S'co^.(^'-t,I

. n-

' , ' ' ' ' . )

il,7 I.

cyry^rQ --, 3\. . - , f i . n ' - ' - "r-J

c(R) = o

Ara

'! i'. i ' ' ; , i r f

* . - l r . t : r I' l r;

. "a

._ Lot'^./t-7 car^rl'AL^s/

l, r t

.rt *t

\' ' , \ -t.1I tt -t l| --tl r vt . '

I r -t -'rcl '*t,T+t -l "L-l ->_Il ->l -l - rt -l -! -t

l * \ - 'I

fst -I1:tl rtI t -1'r \IL-t :

:-_-I

L\I

r >-.t -

5la

,+

:'t

7"

9'

f# ) i,o*= \ {z'. ,!tdt . / ' . - - _; t ia, __L

vr/ = *, e G,#il* ,*, (i6G,^, i{)l r,*,.r!,r.{.)

' v' \ a' t'1"itta ' : 'l'-i 'Wi

t k1? i!r:,::#d;0.* r r: i : t i , lr ') 7 + (!g,. i to)

A;i(, ,*)=D r *#:t ' : )( f \ :) i f ; :P)

7 TF'--O I - ' \ i ' \ - f - :: f y. f f#

JrC a I ' " .* ; : itr- -- Al

fL= A,. +A, I r ) ' rc 11 ,l 7?" f i " ;3:

c(r t .A, . + I " ,o iu

A, ' - c* ! )'.<, i ,

er<FQ: L

L-

Ar"

AtLrn fa-

Cz

- ry.cA(

Ac-r. A*&-*

- c,-n , t \7)

-> s7'n*'o{;u

c(r)= G(r -

Page 5: UCSF Department of Pharmaceutical Chemistryhuanglab.ucsf.edu/Chem241/Chm241_Pitera_PhysKin_notes.pdf · Created Date: 10/18/2013 2:45:38 PM

- ' . i i i ) ' l

.|3i ar.**q"-!

, / ' .. r , ;1t t

\ . /

t t '

-4 l:{['*r- -c*,'*".ollt[ n^*<[Pt"t

5PLr-r+* -- P'olei..t ,

1. - ! - . r \ -it "-' ;':, -\

J' l, )

't' l.

-J' 1

-r-1l;_

\J]

!r--

'J

.r-

-,*\f*

'C.-- ;

'{D'

9,

t - i -

ts,

dta

\t

d_t

- lr l

. tflT

,d

I

4T

tJ

\ r . ' I. , ! - : r L* -c l ' :

;1t i1 j ' - ;

:il-;, * ,1

- 'J i " . i i ' , I, - j .

, - i

. " : - t , - i

- l " -, ; . f ' ,

. j : t r : -

. , ! r - . - r l i - r i l

'yI," *

'" kr*.' = -1-(4/c,. l ; { } .* ' - l - r' ^r t -

. f i \q' i : : ; t * '1.t+ * - i - 'c" ' ;-" i .

j f " . - - r t :

I

. i. l .r ;:: ,:; '. j i: . i - .? -

t

a

l ,A .

.1

. l

- : . \ :

I

1-2-)

'l* q

"a\

\11

- ] r

i * \* i

. a ' ; : r - - ' ' . i ) s. )*. ! ._

<F-\>/ ;\

i lrr

5q---_

Page 6: UCSF Department of Pharmaceutical Chemistryhuanglab.ucsf.edu/Chem241/Chm241_Pitera_PhysKin_notes.pdf · Created Date: 10/18/2013 2:45:38 PM

'tar-

\

\

-a\,

\,

\

^:a7a

"L

ir-I

l *

t :{ '

i 'Jt '1^.1-

II

rl ,

f"r

i.* t

l+io,* b:uln17| . . .

it ' o'L

l. =,. * ill .r\ . r. i-

" , ;

( , ' * - ' i -a*

I+= J^+rt$r

tr^.] ' tL) - r^L tco ' L

[^ c(l)- In co : *t

l^ c(l),. ln co * .^*

-^t( (+) . .re",

' t t

Jl * J:;t (r'f.,"Itn) f, tA- , 1\ , t , \

; _iJ = t i, * . , 1*li,\\ *' :'rt, i.+*r..r1 tft-' :-a( (t ) - b c' (t'J i" ' - -* ' f /

' i t : " i ' : "

is

"tt 'l#*io^

: tt**Sh 6rr .J'tfu]r

.1 d: * ,t;,, ', ',.J'p;1:

-1 - . i \ l . i : l "vr i

- j :x . r^. ] l r ' ' i ' t r

. r i i \. i+?J

ic*i 1!*olrr - 'n lc,- : q j

-i f.

t-tt '

'J

. , : .

J

:

: r0\)

:

. -.''rlli .,'r ""'l!

:1

.- .6Y.

+l:-.j

.. \ *"" . t . : r

r - - l r l| { , / i?

\ '4, i

tv'a

*

*

--vi

rf

Page 7: UCSF Department of Pharmaceutical Chemistryhuanglab.ucsf.edu/Chem241/Chm241_Pitera_PhysKin_notes.pdf · Created Date: 10/18/2013 2:45:38 PM

' t , ' r r - r - - | l l l l l

lq. '1|,lfiv:\n"i r rXA 1 -:.&

T}I

\ . ,^ , , i , . . . , j i : "_;-n ," , .o

tor l tI

^l *ti ,((r) = A, g& * Ar sl f f i :_ l t)--: IE

h c Ac ) ' n-'Jn/o

*r,= ,.\;,

'r re-^c{tc"

-VrrC

l'5'l.Lt+ @ 'r: o

tIl--->0x

&) 'o[f"')*,f7 -CJ,-

kc; b#

hr:=+I-g,*]' JLb Jo

; ,'frr * 4l' tl :

, *^

^\ :. 4"'

/ r

c(o)rs -?> ;ge' oli'

c(o) . A, .fr* -- ,i.r,,.-*. ,r.ri:pA;'"if'""r1:r1

iisl

-- c(o)e' {

=\

JJ3Jj

Jla.J

:

;

iiI

Page 8: UCSF Department of Pharmaceutical Chemistryhuanglab.ucsf.edu/Chem241/Chm241_Pitera_PhysKin_notes.pdf · Created Date: 10/18/2013 2:45:38 PM

6t{,.rtio, k fi*t

, l,(

\-

\

F-l { .Il , :l *l *iLI -{-

J--

' 'L'/r-lr -1." L

l -LtLI r r

1LI"t \ .tI

Il -

ft^,-A iLl., 5,/,n

r rr l l 'drtkJ!'6^ .lSvr\,L1 o('Cr'rb \\

,

flrr.t

6rJ*". 9^rt' cho.r-tltt,r l'

. t )L t+N-/"Dx F-\. ) . I ID; : *M

)

lnt

\iqrld\: - lr.ic,l'l"tl ' . , . .

. ' : ;1 ' t i " '

[ " 6uJ^r, = c'/ a

f l r r (oL'" ,1, , E' ItL. rn ClI -\,)b (r) 2T

c(v) -,'r(t)/{\f ,o)=c

. . , ._! , t_- , -

r ^r \' ' ) u:( - . ,t \ . - \ :

i^ t . **<"uLJ: - f+

" i - s-:,/-l ..t

Ir\2(*a

L

-L

-e-

\,.,L,

\.

-3

{r'

' * -

fJ= e\

\=?=> trr$Srl,r^ ''r'S * .-'tt:)l!"v{ .

: , t l i : 1 l. - " , ' , ] , . ) i ; i iA;Jh: ' ; ' : i -1 i 'Yi ; : -1r

r ' i " '&1 :" i ' L ' | i

G---/ l,t*Sh1*- r

IJ

Hr .t

f_*

Is

-3

J<r,

*-

f,^t N, F,*L i'*b stft

Page 9: UCSF Department of Pharmaceutical Chemistryhuanglab.ucsf.edu/Chem241/Chm241_Pitera_PhysKin_notes.pdf · Created Date: 10/18/2013 2:45:38 PM

sk^rx,s t s(:{rrl,^\ j , " .

L-

.f i rf , l3^.rlrr, *lio^.i-rticalr.fn.S 0f d;ttW>;,,.. l)roul^'r{ rlo1l

,r,. I i.,: i

"1. . - t ' , \p

: !j

I

-,i !,1

t- . . - , ,

r \ - lr"i...t$i 1]\t . "'" . r$ j , "

' ' " i i .

6l(rp."'uL

tJ

. l to '" ' lWc[" ,N).1" i l1to

' (*)' tJ -- eJ>"f .-,i , t i i - : t "

(r\ = tll\t

L l ' . iv \L\ i . . . \' - , ; ' . ;A-tT_-

- ' ,x- , -ptntlo,s U@il*'

, r ! I , r

. . . \ . - . r ' , r

: - - . lr *'l ',

'-Ii '_r-

. , t r

--i-

, {a * : l!

+

r ;::. - t". \*:

"qJ.{n^ {"rhA,n -llsslpa'k,r'

<J

\r i . . . , l t : r , , .*- . - - ' tJ

'$, ' - - ' \ ' ' * -

i

Page 10: UCSF Department of Pharmaceutical Chemistryhuanglab.ucsf.edu/Chem241/Chm241_Pitera_PhysKin_notes.pdf · Created Date: 10/18/2013 2:45:38 PM

=

-7r,r l

f:"s\,:,'- - (, \'.r"L-,rl.i

l

_r(^)lr:e

? El*{un - S,'n{.r"1-"rl-,

IYJ

(#\"o

N['*)- fN*: +'r'1'-,^h

14 : "-

ue)/ql e)

c(o) E

6\ s tfr

\ :Fc(x)at)

Y/

\-/

Page 11: UCSF Department of Pharmaceutical Chemistryhuanglab.ucsf.edu/Chem241/Chm241_Pitera_PhysKin_notes.pdf · Created Date: 10/18/2013 2:45:38 PM

C, i, J'p ApJ,^t

N- | . : rr.. - 6Tff ̂

"tr^\5 , (T\(

t-/ !r",'n

.^,bo

.D:p\"rrtr Slol^l'. L-

b Sf't6- Fnsl'"\^

[r1'... 18. l]

i,. Al ro'r! +I ,n*

,.- fi#

nrr'uvtX,u$:ts

--+ ,t"f"^ 'r.\f" {*"^, X= O } -, O

P(*,N) = A s-'"/'^t' ArN)t

c(r, , I \ . -no - u-{s*w ) - &lr\+)u.

[,.,- ,*.J-^ *JL- r (^ t) = N = ll\t

ld ' ( r t )= U :6b+

5U= 2\*

3\ . (x ' ) '

\=- it

\.o-,r\^^ ,*d^*

t\u<\-r^h,t' - il"' rr\ f,.h,r',". {\u'"t n^,

"{^\. "t c<l^x^}i'^ V, yt:L*.'* 4+

4td,! ""1.0,"*rL\^ {^.tl-.. (r(o).r(+}

G*rr,-\Guo.. "uqFt^5^h,^ [,,..cl,I,.r {a

1'l.^J." { y;l;I,:*, firot oJl^

1

^' l*-*p*I o.S,c\qt

,JLIa-

S: ('v c"li G)) u ' 3N