u01 project presentation: msm of primary motor cortex (m1) · u01 project presentation: msm of...
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U01 Project Presentation: MSMof primary motor cortex (M1)
Bill Lytton
Gordon Shepherd
SUNY Downstate, Kings County Hospital, Northwestern University
Mar 2, 2015 15:00
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Multiscale modelingScales of investigation
Lytton (DMC,NW) NeuroSimLab.org Mar 2, 2015 15:00 2 / 23
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MSM Neurotechnologies
Lytton (DMC,NW) NeuroSimLab.org Mar 2, 2015 15:00 3 / 23
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Neurotechnologydynamical fitting (cell and net, CNR)large networks (HPC technology, Yale)Databasing and data-mining (Yale, UCL)Future: down to RxD; up to multi-area
Neural dynamics and codingSignal transforms (sensorimotor transforms)“Packets” via δθαβγMultiplicity of codes
Neurobiology of disease and treatmentAutismBMISchizophrenia
Lytton (DMC,NW) NeuroSimLab.org Mar 2, 2015 15:00 4 / 23
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Moving away from Frankensteinnetworks
1 species
1 age range
1 lab
1 set of techniques
Lytton (DMC,NW) NeuroSimLab.org Mar 2, 2015 15:00 5 / 23
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Interactions between levelsBipartite output/STR-SPI code transformation hypothesis
Lytton (DMC,NW) NeuroSimLab.org Mar 2, 2015 15:00 6 / 23
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Complex parameterizations:voltage-sensitive ion channel level
Lytton (DMC,NW) NeuroSimLab.org Mar 2, 2015 15:00 7 / 23
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Pyramidal neuron model complexity
Lytton (DMC,NW) NeuroSimLab.org Mar 2, 2015 15:00 8 / 23
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Fitting different aspects
Lytton (DMC,NW) NeuroSimLab.org Mar 2, 2015 15:00 9 / 23
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Praxis (principal axis method)
Lytton (DMC,NW) NeuroSimLab.org Mar 2, 2015 15:00 10 / 23
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Neural Dynamics and coding
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A century of layers
Lytton (DMC,NW) NeuroSimLab.org Mar 2, 2015 15:00 12 / 23
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Cell layout: ‘y-fraction’
Lytton (DMC,NW) NeuroSimLab.org Mar 2, 2015 15:00 13 / 23
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Betweenness centrality viewnodes present in higher proportion of shortest paths
Lytton (DMC,NW) NeuroSimLab.org Mar 2, 2015 15:00 14 / 23
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Dynamics of a networkNeed to improve LFP generation
Lytton (DMC,NW) NeuroSimLab.org Mar 2, 2015 15:00 15 / 23
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Machine learning for biomimesis2-stage learning EA then STDP
Lytton (DMC,NW) NeuroSimLab.org Mar 2, 2015 15:00 16 / 23
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Multiplexing of multicodesLikely many codes coexist
Rate code (Adrian)
First-wave code (Thorpe)
Synchrony code (Singer)
Phase code (Lisman)
Point attractors (Hopfield)
Lytton (DMC,NW) NeuroSimLab.org Mar 2, 2015 15:00 17 / 23
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Cross frequency relationsReality on L (rat L medial PFC)
frequency (Hz)
freq
uen
cy (
Hz)
Lytton (DMC,NW) NeuroSimLab.org Mar 2, 2015 15:00 18 / 23
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NEURON simulation environment
Lytton (DMC,NW) NeuroSimLab.org Mar 2, 2015 15:00 19 / 23
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ModelDB: Simulation databasing
Lytton (DMC,NW) NeuroSimLab.org Mar 2, 2015 15:00 20 / 23
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NEUROML/Open Source Brain
Lytton (DMC,NW) NeuroSimLab.org Mar 2, 2015 15:00 21 / 23
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Lytton (DMC,NW) NeuroSimLab.org Mar 2, 2015 15:00 22 / 23
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BRAIN, HBP/BBB, ABIBrain research through advancing innovative neurotechnologies
Lytton (DMC,NW) NeuroSimLab.org Mar 2, 2015 15:00 23 / 23