twiv 216: processing viral rna mrnas 1 00 map units adenoviral dna late 11 pre-mrna 5' c 12 iwo...

24
TWiV 216: Processing viral RNA Virology 101

Upload: nguyennhan

Post on 09-May-2018

219 views

Category:

Documents


4 download

TRANSCRIPT

TWiV 216: Processing viral RNA

Virology 101

4

m7GpppG

5

6

7

8

mRNA splicing discovered in adenovirus infected cells

10

Splicing of pre-mRNA

11

RNA-RNA interactions during splicing

12

RNA catalysis without protein

13

Alternative splicing

14

Alternative polyadenylation and splicing

15

Control of RNA processing during retrovirus infection

16

Alternative polyadenylation and splicing during adenovirus infection

17

Viral proteins can regulate alternative splicing

18

19

Rev protein regulates export of HIV mRNAs

20

Mechanism of Rev protein mediated RNA export

21

Retroviral mRNA export without Rev protein

22

For temporal regulation of viral gene expression, or inhibition of the production of cell mRNAs

23

Editing of viral mRNAs

24

RNA editing produces mRNA for Ebola virus glycoprotein

25

Editing of hepatitis delta satellite virus RNA

26