tuskegee syphilis experiment
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TUSKEGEE SYPHILIS
EXPERIMENT A presentation by,
Athul Mohan
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Also known as the Tu skegee syphilis stud y or
Public Hea lth Se rvice syphilis stud y.
Was conducted bet ween 1932-1972 in
Tuskegee, Alabama b y the US Pub lic Hea lthSe rvice.
Exper imented on poor rural Afr ican-Amer ican(black) men.
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Aim:-T o stud y natu ral progress ion of unt reated
syphilis.
Study Details:
Enrolled 600 subject s fro m Alabama
399 di seased 201 n on-diseased
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F ree medica l care, mea ls and fr ee bu r ial insurance were given t o them .
Never t old the y had syphilis nor were the y t reated .
T old the y were being t reated for ´bad b loodµ(syphilis, anemia, f atigue, etc .).
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A doct or draws blood fro m oneof the Tu skegee te st subject s
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Stud y was cont rovers ial for reasons relatedt o ethica l matte rs
Researche rs knowingly f ailed t o t reatpatient s af te r penicillin discovery in 1940s.
Penicillin had bec ome the standa rdt reatment b y 1947 .
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D oct ors had 2 ch oices:-
� (i) T reat a ll syphilis subject s and c lose thestud y
� (ii) S plitting off a cont rol group for te stingwith penicillin
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In stead, c ontinued with out t reating thesubject s.
Subject s were uninfor med ab out thei r disease and it s cure(penicillin).
Also were prevented for m acce ss ing syphilis t reatment programs.
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B y the end of the stud y in 1972, only 74
were a live.
40 of thei r wives had been in f ected and 19
of thei r children were b orn with c ongenita l syphilis.
Most in f amous biomedica l research stud y inUS hist ory.
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Study Termination:
In 1972, a leak t o the press resulted in thete rmination of the ex per iment .
Pete r Buxt on, a vene rea l-diseaseinvestigat or in San F rancisco is consideredas the ¶whist leb lower·.
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E thical Implications:
Af te r the di scovery of penicillin, which was an eff ecti ve cu re t o the di sease, the stud y continued for anothe r 25 years with outt reating th ose suff er ing fro m the di sease.
Af te r the stud y ant it s consequence s became fro nt- page ne ws, it was ended in ada y.
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Aftermath:led t o major change s in U.S . law andregulati on on the pro tecti on of par tici pant s in clinical studie s.
led t o the 1979 Belmont Re por t and theestab lishment of the O ff ice for HumanResearch Pro tecti ons (OHRP).
also led t o f ede ral laws and regulati ons requir ing Instituti onal Review Boards for thepro tecti on of human subject s in studie s involving human subject s.
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On Ma y 16, 1997, President Bill
Clinton for mally apologized and he ld aceremon y for the Tu skegee stud y par tici pant s where 5 of the 8 remainingsurvivor·s attended .
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Thank You«