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TRANSCRIPT
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Trinity Centre for Bioengineering
2013
Annual Report & Profile
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Trinity Centre for Bioengineering
1. Message from Director 4
2. Research Showcase 6
3. Strategy and Research Plan 19
4. Education 21
5. Communications 24
6. People & Partners 25
7. Papers 34
CONTENTS
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Trinity Centre for
Bioengineering 2013
4
Welcome to the 2013 annual report of the Trinity Centre for Bioengineering
(TCBE). Established in 2002, the TCBE brings together Principal Investigators,
research fellows, postgraduate students and undergraduate students from the
School of Engineering, the School of Medicine, the School of Dental Science and
the School of Natural Sciences in Trinity College Dublin (TCD), as well as
colleagues from the Royal College of Surgeons in Ireland (RCSI), University College
Dublin (UCD) and Dublin City University (DCU). The aim of the Centre is to promote and facilitate
research and education in Bioengineering in Bioengineering and related disciplines, and to ensure
this research finds its way into the clinic in order to improve patient care.
This annual report gives an overview of the TCBE’s core personnel and our key research and
educational activities over the 2013 calendar year. TCBE researchers work across five different
research themes: Musculoskeletal Research, Biomaterials, Regenerative Medicine, Cardiovascular
Research and Neural Engineering. This report demonstrates the impact that TCBE researchers are
making in these fields and beyond. This can be measured in many ways, from publications in
leading journals to the development of new products and the establishment of spin-out
companies. For example, 2013 has seen further growth in the number of peer-reviewed papers
published with over 85 papers published by TCBE researchers in the calendar year (source:
scopus). Citations to TCBE papers also increased to over 1800 in 2013 (excluding self-citations). In a
challenging funding environment, this is a remarkable achievement.
I would like to highlight just a small number of our achievements from the past year.
2013 saw TCBE PIs continue to attract grant funding from numerous different sources, further
details of which are available in this report. Of note was Dr. Garry Duffy’s €8.7 million EU FP7
project ‘Advanced Materials for Cardiac Regeneration’ (AMCARE). The aim of this project is to
develop natural materials and new surgical devices to enhance the delivery of the body's own
stem cells to the heart to promote healing after a heart attack (myocardial infarction) and
prevent premature death.
The new AMBER (Advanced Materials and BioEngineering Research) Research Centre, funded
by 19 Industry partners and Science Foundation Ireland (SFI), was officially launched on the
24th of October 2013 in Croke Park, Dublin. Further details are available in the report.
DIRECTOR’S MESSAGE
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Collaborating Countries TCBE publications are co-authored with researchers from 35 countries worldwide
In January we hosted the 19th Annual Conference of the Bioengineering Section of the Royal
Academy of Medicine in Ireland (RAMI) in Johnstown House Hotel, Co. Meath. Nearly 200
delegates attended the conference. Prof. Richard Reilly delivered the Samuel Haughton lecture for
which he received the RAMI silver medal.
Two new PIs joined the Centre in 2013 - Prof Sally-Ann Cryan from the School of Pharmacy in the
Royal College of Surgeons in Ireland and Prof Martin Burke from the Department of Electronic and
Electrical Engineering in Trinity College Dublin. In addition, we have also had 15 new clinical PIs
join the Centre. These are clinicians who are already working closely with PIs in the TCBE – further
details can be found at http://www.tcd.ie/bioengineering/people/investigators/.
Fergal O’Brien and I submitted a successful bid to host the 2018 World Congress of Biomechanics
in Dublin. This conference takes place every 4 years, and we hope that it will attract over 3000
delegates to Ireland in 2018.
I hope you enjoy reading this report.
Kind Regards,
Prof. Daniel Kelly - Director of the Trinity Centre for Bioengineering
DIRECTOR’S MESSAGE
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Trinity Centre for BioEngineering 2008-2013
Number of Publications: 633
Number of Citations without self-citations: 9728
Impact (Average Citations per item) 15.37
H-index: 46
Source: Web of Science
0
20
40
60
80
100
120
2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013
RESEARCH SHOWCASE
Publications by Year 2003 - 2013
7
Countries citing TCBE papers 2008-2013 TCBE publications attracted 3,574 citations
TCBE publications 2002-2012 attracted 7,300 citations from 93 countries worldwide
RESEARCH SHOWCASE
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Total Grant Funding Awarded 2013: €14,042,883
Programme Principal Investigators
Collaborators Research Funding
Science Foundation Ireland US Ireland R&D Partnership
Kelly D
Prof. Tammy Donahue (Colorado State), Dr. Nicholas Dunne (Queens University Belfast).
Development of a Novel Bioinspired Fiber Reinforced Hydrogel that Recapitulates Developmental Processes to Regenerate the Bone-Ligament Interface
€254,639
Feasibility IPP grant Enterprise Ireland
Murphy B
ELIVE medical ELIVE medical and TCD laser therapy IPP project
€9,000
Enterprise Ireland Murphy B
NUIG and Dr. Jim Crowley
Development of a transcatheter mitral valve replacement system
€286,000
Irish Research Council Buckley C
Sole awardee Irish Research Council Government of Ireland ‘New Foundations’ Scheme 2013
€5,270
Irish Research Council Student Award
Lalor E
Sole awardee Decoding complex concepts from neural data
€96,000
European Commission Reilly R
Sole awardee FET Flagship Human Brain Competitive Call for additional project partners
€151,875
Enterprise Ireland Reilly R
Sole awardee Commercialisation Fund - Commercial Case Feasibility Study
€573,742
SFI Principal Investigator Award
Kelly D
Prof Fergal O’Brien (RCSI); Dr Conor Buckley (TCD); Prof Pieter Brama (UCD); Dr Paula Murphy (TCD); Dr Mary Murphy (NUIG); Mr Kevin Mulhall, (Consultant Orthopaedic Surgeon, Mater University Hospital).
A tissue engineered biological joint replacement prosthesis for the treatment of degenerative joint disease
€1,700,000
Enterprise Ireland Commercialization Fund (2013-2104)
Kelly D
Prof Fergal O’Brien (Royal College of Surgeons); Dr Conor Buckley (TCD)
A novel bioactive scaffold for articular cartilage regeneration
€172,962
European Commission Framework 7 NMP Project
Duffy GP Cryan SA, Kelly H, Heise A.
Advanced Materials for Cardiac Regeneration (AMCARE). 2013-2018
€8,696,504
RESEARCH SHOWCASE
e/
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RESEARCH SHOWCASE
Programme Principal Investigators
Collaborators Research Funding
European Molecular Biology Organization Travel Fellowship
O’Brien FJ Kirkpatrick CJ, Lloyd-Griffith C.
In vitro vascularisation of scaffolds for bone repair using a human dermal microvascular endothelial cell/ human amniotic fluid-derived stem cell co-culture system
€8,086
Irish Research Council ELEVATE Fellowship 2013
Haugh M, Heilshorn S, O’Brien FJ (Co-applicant)
Haugh M, Heilshorn S, O’Brien FJ (Co-applicant)
A recombinant approach to cell-matrix interactions and vascular tissue engineering 2014-2016.
€238,947
Irish Research Council Government of Ireland Postdoctoral Fellowship 2013
Cameron A, O’Brien FJ (Co-applicant) Collagen-based, layer-specific, tissue engineered constructs for partial and full thickness corneal repair 2013-2015
€91,790
Irish Research Council Government of Ireland Postgraduate Scholarship 2013
O’Brien FJ Lackington W. Advanced scaffold-based therapeutics to facilitate nerve regeneration. 2013-2017
€96,000
Enterprise Ireland (EI) Commercialisation Fund Programme Commercial Case Feasibility Support
Cameron AR O’Brien FJ(Co-applicant)
Development of a novel collagen based film for corneal repair
€14,900
Science Foundation Ireland (SFI) Research Centres Programme
Boland J Coey M, Coleman J, Duesberg G, Morris M, Holmes J, Sanvito S, Kelly D, O’Brien FJ(Co-PI), Nicolosi, V.
Advanced Materials and BioEngineering Research Centre (AMBER) €58,000,000 (€23 million of which is from industry). FOB allocation: €952,527 2013-2019
€952,527
Royal College of Surgeons in Ireland, Alumni Office Summer Studentship
O’Brien FJ (Co-applicant), Widaa A.
Scaffold-based systems for antibiotic delivery
€2,000
Royal College of Surgeons in Ireland Alumni Office Tom Garry Research Fund
O’Brien FJ (Co-applicant), Widaa A
Scaffold-based systems for antibiotic delivery
€1,563
Royal College of Surgeons in Ireland, Alumni Office Summer Studentship
O’Brien FJ (Co-applicant), Roche P.
Collagen scaffold-based therapeutics to facilitate nerve regeneration
€2,000
Royal College of Surgeons in Ireland, Alumni Office Tom Garry Research Fund
O’Brien FJ (Co-applicant), Brady R..
Effect of mechanical stimulation and estrogen deficiency on osteogenic differentiation of bone-marrow derived MSCs
€1,563
Enterprise Ireland Commercialisation Fund.
Kelly D, Buckley, C, O’Brien FJ (Co-applicant), Robinson, A. Kiely, P.
Natural ECM derived injectable microparticles for regeneration of the intervertebral disc (DiscReGen) 2013-2014
€135,495
Science Foundation Ireland (SFI)/ Enterprise Ireland (EI) Joint Technology Innovation Development Award Programme (TIDA)
Lopez-Noriega A (Principal Investigator), O’Brien FJ (Co-applicant).
Collagen based scaffolds as a platform for the controlled release of bioactive molecules
€129,169
Enterprise Ireland Commercialisation Fund
Kelly D, Buckley, C, O’Brien FJ (Co-applicant)
A novel bioactive scaffold for articular cartilage regeneration
€224,851
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RESEARCH SHOWCASE
Programme Principal Investigators
Collaborators Research Funding
Enterprise Ireland Commercialisation Fund
Kelly D, Buckley, C, O’Brien FJ (Co-applicant)
A novel bioactive scaffold for articular cartilage regeneration
€224,851
Chinese Scholarship Council/TCD (2013-2016)
Simms, C Optimisation of vehicle design for pedestrian protection
€88,000
TCD E3 Initiative (2013-2016)
Simms, C Optimisation of vehicle design for pedestrian protection
€60,000
Norwegian Research Council
Burke, M Laerdal Medical Ltd., Stavanger, Norway
Development of amplifier for dry electrode ECG measurement in newborn
€50,000
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RESEARCH SHOWCASE
AMBER
Advanced Materials and BioEngineering Research
AMBER brings together Ireland’s leading material science researchers working across the disciplines
of Physics, Chemistry, Bioengineering and Medicine; with an international network of collaborators
and companies and it is great that the Trinity Centre for Bioengineering is part of this. We hope to
expand the medical device activities of AMBER over the coming years by adding new spoke projects
to the Centre
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Crescent System® – Percutaneous Local Drug Delivery Prof Bruce Murphy and Dr Garrett Ryan have created the Crescent System®, a catheter based system designed to inject — directly and non-systemically — therapeutic agents safely through blood vessel walls into deep tissues. With this enabling technology, novel therapies can be developed and delivered site-specifically nearly anywhere in the body. These therapies may include treatments for renal denervation, plaque stabilization in diseased vessels, anti-tumor drugs, growth factors to stimulate cell division, and stem cell transplantation and gene therapies. Delivering drugs through the blood vessel wall into the perivascular space and adventitia allows for direct, highly controllable and concentrated treatment, minimizing the toxicity of systemic administration, while avoiding the “washing away” of drug into the bloodstream. This can reduce drug side effects, increase therapeutic effectiveness, potentially decrease the cost of medical treatment and improve patient quality of life
Crescent System – ‘Deflect and Inject’ technology platform The Crescent System has the following competitive advantages:
Control: The Micro-Infusion Catheter needle precisely targets an injection. Efficiency: Compounds are delivered to the outside of the vessel without systemic
washout. Safety: Unlike conventional infusion catheters with pressure jets or larger, unsheathed
needles, the Crescent System needle — with a width of only two human hairs — does not injure the vessel wall.
Feedback: Perivascular delivery is immediately visualized with minute amounts of contrast medium, proving positively that the drug is localized at the target.
Consistency: The Micro-Infusion Catheter provides the most repeatable dose control of any prior infusion-based catheter system.
Sizing: The Micro-Infusion Catheter provides a 1 size fits all from vessels ranging from 3-9mm in diameter, thereby reducing hospital inventory and cost.
RESEARCH SHOWCASE
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Engineering zonal cartilage grafts
Engineering organs and tissues with the spatial composition and organisation of their native
equivalents remains a major challenge. One approach to engineer such spatial complexity is to
recapitulate the gradients in regulatory signals that during development and maturation are
believed to drive spatial changes in stem cell differentiation.
Mesenchymal stem cell (MSC) differentiation is known to be influenced by both soluble factors and
mechanical cues present in the local microenvironment. The objective of this study was to engineer
a cartilaginous tissue with a native zonal composition by modulating both the oxygen tension and
mechanical environment thorough the depth of MSC seeded hydrogels. To this end, constructs were
radially confined to half their thickness and subjected to dynamic compression (DC). Confinement
reduced oxygen levels in the bottom of the construct (see Fig 1) and with the application of DC,
increased strains across the top of the construct. These spatial changes correlated with increased
glycosaminoglycan accumulation in the bottom of constructs, increased collagen accumulation in
the top of constructs, and a suppression of hypertrophy and calcification throughout the construct
(see Fig 1). The combination of spatial confinement and DC was also found to increase
proteoglycan-4 (lubricin) deposition toward the top surface of these tissues. In conclusion, by
modulating the environment through the depth of developing constructs, it is possible to suppress
MSC endochondral progression and to engineer tissues with zonal gradients mimicking certain
aspects of articular cartilage.
This study was undertaken in Dr. Daniel Kelly’s lab and was published in PLoS One.
Fig 1. Left: Predicted oxygen levels within unconfined and confined MSC laden hydrogels. Right: MSC laden
hydrogels stained with alizarin red to determine calcific deposition.
RESEARCH SHOWCASE
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Orchestrating osteogenic differentiation of mesenchymal stem cells
The bones in our body have an inherent capacity to respond to mechanical loading. For example,
astronauts subjected to long term periods of weightlessness in microgravity lose bone mass due to
underloading while the dominant serving arms of professional tennis players gain mass due to excess
loading. The work in this article sought to gain a greater understanding of the mechanisms involved
that cause cells to respond to mechanical loading. Mesenchymal Stem Cells (MSC) were grown on a
highly porous collagen scaffold to present the cells with an environment more representative of the 3D
native tissue than typical 2D petri dishes (Fig. 2). These cell-seeded scaffolds were then subjected to
mechanical loading through the application of fluid flow using a flow perfusion bioreactor (Fig. 3).
Advanced gene array technologies were subsequently employed to initially screen over 24,000 genes
in an effort to identify those that were altered as a result of mechanically loading. Genes which
demonstrated large changes following stimulation were shortlisted for further analysis. Placental
Growth Factor (PGF), known to have involvement in fracture repair but not until now linked to
mechanosensitivity, was one such gene that exhibited a greatly increased level of expression in
response to the applied flow conditions and was selected for further evaluation. We demonstrated
that PGF expression levels correlated to both the magnitude and duration of flow exposure. By then
applying recombinant versions of this protein to different cell types, the study demonstrated a clear
concentration-dependant response with respect to 3 keys phases of bone physiology; vascularisation,
resorption and bone formation (osteogenesis). Lower PGF concentrations had the strongest pro-
osteogenic effect, whilst higher concentrations favoured vascularisation and bone resorption. This
work has helped to expand the knowledge space pertaining to the mechanical regulation of bone
formation and remodelling, whilst also providing a novel therapeutic target for further study with
respect to enhancing bone regeneration in clinical applications. This study was undertaken in Prof.
Fergal O’Brien’s lab and was published in Stem Cells.
.
Fig. 3. Schematic of flow perfusion
bioreactor used to subject stem cells
grown on a collagen scaffold to
mechanical stimulation.
Fig. 2. SEM image of cells grown in a porous collagen scaffold.
Cell morphology influences cellular response to mechanical
loading. One cell in this image is bridging the pores of the
scaffold (purple) while two cells remaining flatly attached to
collagen struts within the scaffold (green).
RESEARCH SHOWCASE
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Shape memory scaffolds for minimal invasive surgery Dr. Buckley’s team published their recent work in Acta Biomaterialia on developing porous alginate scaffolds with shape-memory properties. These materials can be delivered using minimally invasive approaches and recover to their original geometry once hydrated. Covalently cross-linked alginate hydrogels were created using carbodiimide chemistry, followed by a freeze-drying step to impart porosity. Results showed that porous alginate scaffolds exhibited shape-memory recovery and can be repeatedly compressed and expanded, which provides the potential to deliver the biomaterial directly to the damaged tissues. Demonstration of shape-memory properties (B) of the deformation capability in dry state and rehydration with cell suspension, (C) and of the elasticity of hydrated scaffolds. (D) Ex-vivo simulation of delivery into a defect in the intervertebral disc. Scale bar = 1cm. (Guillaume, O., et a, Acta Biomaterialia, In Press)
Biomaterials research in the TCBE spans many biomedical application areas. Projects carried out
during 2013 involved shape memory scaffolds for minimal invasive surgery and decellularised
scaffolds for peripheral nerve regeneration
Fig scaffolds. (A)
Shape-memory characteristics of covalently crosslinked porous alginate
RESEARCH SHOWCASE
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Regenerative Medicine
Decellularised scaffolds for peripheral nerve regeneration MSc Bioengineering student Rukmani Sridharan was awarded "Best overall MSc Thesis in Bioengineering 2013" for her work entitled "Freeze dried, acellular nerve scaffolds with longitudinal channels for peripheral nerve regeneration". This research was a collaborative project between the groups of Dr. Buckley and Prof. Reilly. This work modified a previously developed decellularization protocol to improve cellular removal while preserving matrix structure in rat sciatic nerve sections and introduced longitudinal oriented channels, 20-60µm (diameter) using a unidirectional freeze-drying process. This study represents the first attempt to modify the physical structure of decellularized nerves to enhance cell penetration which may serve as a basis for future peripheral nerve regenerative strategies using acellular allografts.
Fig: Decellularised scaffolds for peripheral nerve regeneration. Sciatic nerve segments were decellularised and subjected to a freeze drying process to induce axially oriented pores.
RESEARCH SHOWCASE
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RESEARCH SHOWCASE
Research Highlights
The Neural Engineering group commenced a new 3-year collaborative project with Cochlear Ltd to develop neurophysiological based objective measures of speech perception in Cochlear Implant users. This project also involves the National Cochlear Implant program at Beaumont Hospital. A paper from the TCBE neural group on cochlear implants was published in Plos One entitled “Objective Assessment of Spectral Ripple Discrimination in Cochlear Implant Listeners Using Cortical Evoked Responses to an Oddball Paradigm” The Neural Engineering group are also advancing cutting edge research in the field of respiratory medicine with a new collaborative project with Vitalograph Ltd to develop bioacoustic based adherence measures for respiratory medicine.
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Musculoskeletal Research Snapshots
Featured papers Takaza, M, Moerman K, Simms CK, “Passive Skeletal Muscle Response to Impact Loading: Experimental testing and inverse
modelling” in press JMBBM, April 2013.
Amato G, O'Brien F, Ghosh B, Simms CK, “Title: Multibody modelling of a TB31 and a TB32 crash test with vertical portable concrete barriers: Model verification and sensitivity analysis” in press, IMechE Journal of Multibody Dynamics, March 2013.
Amato G, O’Brien F, Ghosh B, Williams, G, Simms CK, “Multibody modelling of gabion beams for impact applications”, in
press Journal of Crashworthiness, February 2013.
Gindre J, Takaza M, Moerman K, Simms CK, A Structural Model of Passive Skeletal Muscle shows Two Reinforcement
Processes in Resisting Deformation, in press JMBBM, February 2013.
Kiernan D., Walsh M., O’Sullivan R., O’Brien T., Simms C.K. The influence of estimated body segment parameters on
predicted joint kinetics during diplegic cerebral palsy gait
Figure 1: The anisotropic nonlinear elastic behaviour of skeletal muscle tissue in compression (A) and tension (B). Thick solid curves are the mean experimental data; thin curves represent the mean response plus and minus. Coloured (toward Cauchy stress kPa) surfaces are periodic surface fits to the mean response and grey transparent surfaces are for the standard deviation offsets. Circled in red are the stretch comparison figures and circled in yellow is the fibre orientation response comparison.
Figure 2: Top Left: Image is taken from a 30% tensile deformed specimen (approximately 150x). Top image right: shows sample with the muscle fibres removed using NaOH 3rd Image. The blue arrows are pointing to perimysium network, the green arrows pointing to endomysium network and the red arrows are pointing to where the muscle fibres have been removed. Bottom image left: SEM image is showing randomly oriented endomysium collagen fibre network when magnified at 4.13kx. Bottom image right: Shows the somewhat organised perimysium collagen fibres.
RESEARCH SHOWCASE
Musculoskeletal
Research Highlights
The Musculoskeletal Group received several awards to fund PhD scholarships. They were awarded a new Ph.D. scholarship under the TCD engineering E3 scheme. The title of the research project is “Passive skeletal muscle form and function: Engineering insights from Zoology”
They were also awarded a Ph.D. scholarship from TCD and the Chinese Scholarship
Council. Student Guibing Li from China commenced a Ph.D. on vehicle shape
optimisation for pedestrian protection in September 2013.
The musculoskeletal group received an award for a collaborative project with
Leinster Rugby and the IRFU, sponsored by the Irish Research Council focusing on
concussion injuries in rugby.
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The Trinity Centre for Bioengineering carries out research and development across a
full range of themes from cell mechanobiology to next generation medical devices.
Improving Human Health
Cell Mechanobiology
Single Cell Biomechanics
Ageing Bone (OP and OA research)
Tissue Engineering
Skeletal Repair
Neuro-musculoskeletal modelling
Next Generation Devices
Neural Engineering and Prosthetics
STRATEGY AND RESEARCH PLAN
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The Trinity Centre for Bioengineering research programme is focused on an integrated programme
investigating the full hierarchy of the body’s biomechanical and bioelectric systems from cell to tissue to organ
along with their interaction with medical devices. Our team of Principal Investigators, postdoctoral fellows,
PhD students and M.Sc. students work in collaboration with twelve hospitals, leading medical device
companies, national and international research centres and universities. This integrated approach is centred
around five specialisations:
Musculoskeletal ● Biomaterials ● Cardiovascular ● Regenerative medicine ● Neural engineering
Research in these areas is based on the intersection of biomedical science and engineering and forms the
foundation for enabling technologies for advances in key areas of active and passive implantable devices,
surgical and medical device design, as well as informing clinical studies and interventions in ageing,
neurodegeneration and rehabilitation.
Cell Mechanobiology
Single Cell Biomechanics
Ageing Bone
(OP and OA research)
Tissue Engineering
Skeletal Repair
Neuro-musculoskeletal
modelling
Next Generation
Devices
Neural Engineering &
Prosthetics
Theme 1: Cell response to biochemical and biophysical stimulation in 3D matrices. The
functionality of cells from both healthy, ageing, and osteoarthritic patients are being
studied, and markers for skeletal diseases are being identified.
Theme 2: The development of novel tissue engineering and regenerative medicine
strategies for tissue and organ regeneration, with a specific focus on orthopaedic and
cardiovascular medicine. Novel biomaterial scaffolds and bioreactors are being
developed for this purpose, supported by the use of computational tools to optimise
the design of such regenerative strategies.
Theme 3: Reconstruction of human function requires an engineering approach through
musculo-skeletal modelling to simulate functional requirements and for the
development of prototype devices for trials in patients. Along with the Trinity College
Institute for Neuroscience, neural engineering research focuses on new brain imaging
methodologies and in-vivo recordings of specific circuits to provide an understanding of
neural mechanisms of behaviour, together with electrical stimulation based
treatments.
Theme 4: is titled “Frontiers in Medical Device Design” and will focus on controlling
cells to perform defined functions as part of the medical device. In silico methods will
be used predominantly to model new concepts in cardiovascular, orthopaedic and
neural implant design.
STRATEGY AND RESEARCH PLAN
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Undergraduate
Postgraduate
PhD programmes
Seminar Series
Undergraduate Bioengineering Stream The new undergraduate stream in Biomedical Engineering commenced in 2012. In 2013 there was
20 students in 3rd year and 25 students in 4th year. These students are working towards an MAI in
Bioengineering.
NEURAL
MEDICAL DEVICES
EDUCATION
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M.Sc. Bioengineering & New Specialisations
The award winning MSc Bioengineering now offers a unique
programme of specialisations that differentiates it to all other
biomedical engineering postgraduate programmes. Students can specialise in Neural Engineering, Regenerative Medicine and
Medical Device Design. Some of the most exciting work in
biomedical engineering today takes place in these three
specialisation strands and our graduates will become the next
leaders in their field making real impact on the human condition.
Students have the advantage of carrying out their research
project in a state of the art Bioengineering environment in the
Trinity Biomedical Sciences Institute. This year there are seven
students taking the Neural specialisation, five taking Regenerative
and three taking Medical Device Design.
Neural Engineering
Medical Device Design
M.SC. IN BIOENGINEERING
MSc in Bioengineering
The M.Sc in Bioengineering is a central pillar of our educational programmes in the Trinity Centre for Bioengineering and contributes to other educational initiatives including the new Biomedical Engineering stream of Trinity College’s undergraduate engineering programme, the five year MAI course, and the Graduate Research Education Programme in Engineering, a structured PhD programme in Medical Devices. In addition, the MSc in Bioengineering is a partnering programme for the Erasmus Mundus Master’s course CEMACUBE (Common European MAster’s CoUrse in Biomedical Engineering). The MSc in Bioengineering has a current intake of 28 students in total this year from all over the world including Mexico, Bangladesh, United States, Serbia and the Netherlands. This year the M.Sc. class of 2014 travelled to MEDICA with TCBE staff Dr. Liam Breen, Dr Sonja Hermann and Dr. Conor Buckley. MEDICA is the world’s leading trade fair for medicine and medical technology held annually in Germany.
Students and staff from the MSc Bioengineering programme attending MEDICA in November 2013.
EDUCATION
Innovating Education in BioEngineering
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COMMUNICATIONS
Seminars
The Trinity Centre for Bioengineering has an extensive research seminar series with international speakers. There are approximately 20 seminars per year across all our research themes. Below is a selection of TCBE seminars held in 2013:
Regenerative Engineering Strategies for Damaged Musculoskeletal Tissues Prof Robert E. Guldberg, The Petit Director's Chair in Bioengineering and Bioscience , Executive Director, Parker H. Petit Institute for Bioengineering and Bioscience , Professor, George W. Woodruff School of Mechanical Engineering Georgia Institute of Technology, USA
Mapping the Mechanome: Multiscale Approaches to Decipher Mechanisms of Stem Cell Mechanoadaptation Melissa L. Knothe Tate, Ph.D., Professor and Paul Trainor Chair of Biomedical Engineering Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia On the relationship between deformation behaviour and microstructure of human dentin Peter Panfilov and Dmitry Zaitsev, Institute of Natural Sciences, Ural Federal University, Ekaterinburg, Russia Methods and Applications of Signal Processing Applied to Speech and Language for Objective Assessment of Cognitive Function in Ageing and Psychiatry Viliam Rapčan, Trinity Centre for Bioengineering Objective rating scales for focal dystonias David A. Peterson, Ph.D. University of California, San Diego, Salk Institute for Biological Studies Multidisciplinary research into bone mechanobiology during normal physiology, disease and to develop bone tissue regeneration strategies Laoise McNamara, Ph.D. National University of Ireland Galway Perception of True Linear Self-Motion using Vestibular Stimulation in Humans: A Mathematical Electrophysiological Analysis Hugh Nolan, Trinity Centre for Bioengineering An Investigation of Structure-Function Relations in Articular Cartilage during Skeletal Maturation Alanna Rose Marie Gannon, Trinity Centre for Bioengineering Towards Engineering Whole Bones Through Endochondral Ossification Eamon John Sheehy, Trinity Centre for Bioengineering
An investigation into the role of substrate stiffness and oxygen availability in the regulation of stem cell differentiation during tissue regeneration Darren Burke, Trinity Centre for Bioengineering
EDUCATION
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Trinity Centre for Bioengineering communicates through several
media including our website, a regular e-zine with the latest news,
facebook and LinkedIn.
Our website can be found at www.tcd.ie/bioengineering. From the
main TCBE website you can navigate to websites for each of our
main research themes where you can find information on the latest
research breakthroughs, news, events and contact details for
research groups.
Our regular e-zine communicates news of all TCBE activities and what our PI’s, Postdoctoral fellows and postgraduate students are doing in the world of biomedical engineering.
TCBE is active on facebook, twitter and LinkedIn with all the latest
TCBE news on education and medical device innovation.
A selection of features from the Trinity Centre for Bioengineering Media Book 2013
Source Media Headline Page/link
Irish Independent
Press and online
'Magic' organic patch mends bone, cartilage
http://www.independent.ie/business/technology/magic-organic-patch-mends-bone-cartilage-29740984.html
10/11/13
Irish Times
Press and online
Research Centre to focus on medical and industrial materials
http://www.irishtimes.com/news/science/research-centre-to-focus-on-medical-and-industrial-materials-
1.1572003
24/10/13
Irish Examiner Press and online
Bruton to announce 58m research investment
http://www.irishexaminer.com/breakingnews/business/bruton-to-announce-58m-research-investment-
611114.html
24/10/13
Newstalk Radio Job creation in research centre
http://www.newstalk.ie/99-jobs-to-be-created-at-new-science-research-centre
24/10/13
COMMUNICATIONS
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PRINCIPAL INVESTIGATORS, 20
POSTDOCTORAL RESEARCHERS, 16
POSTGRADUATE RESEARCHERS, 55
M.SC. STUDENTS, 30
, 0
PRINCIPAL INVESTIGATORS POSTDOCTORAL RESEARCHERS POSTGRADUATE RESEARCHERS M.SC. STUDENTS
PEOPLE
Dr. Martin Burke
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Dr. Daniel Kelly Director TCBE Affiliation: TCD School of Engineering Contact Email: [email protected]
• Mechanobiology of Mesenchyaml Stem cells
• Cartilage Tissue Engineering
• Vascular mechanics
Dr. Bruce Murphy Deputy Director Affiliation: TCD School of Engineering Contact Email: [email protected]
• Aortic Valve regeneration
- Mitral valve regurgitation
• Local therapeutic delivery to
diseased blood vessels
• Force focused angioplasty
• Vascular tissue engineering
Dr. Patrick Prendergast Honorary PI Affiliation: Provost, University of Dublin TCD School of Engineering Contact Email: [email protected]
• Biomechanical engineering
• Analysis of medical devices
• Computational modeling of medical
device performance
• Stem cell mechanobiology (viz.,
understanding how stem cells
differentiate in response to
mechanical forces).
Prof. Clive Lee Chair Affiliation: RCSI Department of Anatomy Contact Email: [email protected]
Bone o Remodelling o Microdamage detection o Fatigue o Regeneration
Osteoporosis
Content aware media processing o On-line anatomy teaching
Dr Conor Buckley Affiliation: TCD School of Engineering Contact Email: [email protected]
Regenerate the intervertebral disc (IVD)
Articular cartilage
Design and development of bioreactor based systems
Tissue engineering
Nutrient micro-environments
Biomaterial interactions
3D scaffold construct technology
PRINCIPAL INVESTIGATORS
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Prof. Veronica Campbell Affiliation: TCD School of Medicine
Contact Email: [email protected]
Apoptosis
Biology
Biomedical sciences
Intra and intercellular signalling
Neurochemistry and neuropharmacology
Neurodegeneration
Neuropharmacology
Physiology
Dr. Garry Duffy Affiliation: RCSI Department of Anatomy Contact Email: [email protected]
Regenerating the heart after ischemic cardiovascular disease through the application of both gene therapy and stem cell therapy.
Promotion of neovascularisation in ischemic tissues
Collaboratively, he is also interested in including tissue engineering bone grafts, ischemic peripheral limb disorders and diabetic
Prof. David FitzPatrick Affiliation: UCD School of Engineering
Contact Email: [email protected]
Evaluation periodontal and implant therapy
Bone regeneration
Orthopaedic Biomechanics
Educational research
Dr. Catriona Lally Affiliation: DCU School of Mechanical Engineering Contact Email: [email protected]
Cardiovascular Biomechanics
Soft Tissue testing
Medical Device Design
Vascular mechanobiology and cell biology
Tissue Engineering
Vascular imaging
Dr. Edmund Lalor Affiliation: TCD School of Engineering Contact Email: [email protected]
Processing of electrophysiological signals reflecting activity of human sensory systems
Multisensory integration
Effects of selective attention on sensory and perceptual processing
Computational modelling of the visual system at various hierarchical levels
The encoding and decoding of sensory information in populations of neurons
Sensory deficits in schizophrenia and autism
Brain-computer interfacing
PRINCIPAL INVESTIGATORS
28
Dr. Paula Murphy Affiliation: TCD School of Natural Sciences Contact Email: [email protected]
• Bone and joint formation in limb
long bones
• Finite Element Analysis of the mechanical environment
• Morphogenesis of the limb and facial region of developing vertebrate embryos
• Generation of a 3D atlas of chick
development with cross reference to
the mouse
• Evolution of regulatory mechanisms
• Morphological and molecular
analysis of mouse models of
congenital abnormalities
Prof. Fergal O'Brien Affiliation: RCSI Department of Anatomy Contact Email: [email protected]
Tissue engineering and regenerative medicine - Natural and ceramic biomaterials - Scaffold design and development - Stem cell biology - Cellular mechanics and mechanotransduction - Bioreactor development - Growth factor and gene therapy - In vivo modeling
Bone mechanics and osteoporosis - Bone remodeling and repair - Microdamage - Novel methods for OP diagnosis and treatment
Prof. Brian O'Connell Affiliation: TCD School of Dental Science Contact Email: [email protected]
Titanium implant surfaces - modification at nanoscale to enhance bone growth
Combination of cell-seeded Collagen GAG scaffolds with titanium support
Use of bone-anchored implants for orthodontic anchorage
Development of intraoral sensor for the diagnosis and management of sleep bruxism
Dr. Kevin O'Kelly Affiliation: TCD School of Engineering Contact Email: [email protected]
Bioengineering o Scaffolds for bone tissue engineering o Synthesis and application of nano-particles of HA o Effects of osteoarthritis and osteoporosis on mechanical properties of bone tissue
Materials o Indentation fracture mechanics o Crack-microstructure interactions in advanced ceramics
PRINCIPAL INVESTIGATORS
29
Prof. Richard Reilly Affiliation: TCD Schools of Engineering & Medicine Contact Email: [email protected]
Functional Neuroimaging
Decoding Neural Activity
Active Implantable devices
Speech and Audio analysis
Dr. Ciaran Simms Affiliation: TCD School of Engineering Contact Email: [email protected]
Injury biomechanics
Vulnerable road user protection
Soft tissue mechanics
Lower back pain in rowers
Medical device design
Prof. David Taylor Affiliation: TCD School of Engineering Contact Email: [email protected]
Mechanical Properties of Biological
Materials
Strength and Fracture of Implant
Materials
o Stress concentration effects in
fatigue and fracture
Bone cement
Dr. Alice Witney Affiliation: TCD Department of Physiology Contact Email: [email protected]
Insect Walking and Sensory integration
Human posture and balance - Sensory influences on postural
control - Simple medical devices to adjust
balance
Human object manipulation
Prof. Sally-Ann
Cryan
Affiliation: School of Pharmacy, Royal College of Surgeons in Ireland
Contact email: [email protected]
Translational & molecular pharmaceutics
Novel biomaterial development for drug delivery & tissue engineering applications
Dr Martin Burke
Affiliation: TCD School of Engineering Contact Email:
Electronic Circuit Design
Biomedical Instrumentation and Applications
TCBE ORGANISATION PRINCIPAL INVESTIGATORS
30
The members of our 2010-2014 International Advisory Board bring their highly valued range of skills, experiences and expert sector knowledge to assist and shape the development and strategy of the Centre.
Prof. Dr. Josep A. Planell is the Director of Biomedical Engineering Research Centre (IBEC, Spain). His area of research is Bio/Non-Bio interactions for regenerative medicine.
Prof. Dr. C. James Kirkpatrick is Professor of Pathology and Chairman at
the Institute of Pathology, the Johannes Gutenberg University of Mainz,
Germany. His principal research interests are in the fields of endothelial
pathobiology, biomaterials in tissue engineering and regenerative
medicine, with a special focus on the development of human cell
culture techniques, specifically around co-culture systems in three-
dimensions.
Prof Bernard Conway is Head of Department of Bioengineering,
University of Strathclyde. His research relates to improving our
understanding of the neuronal mechanisms that contribute to the
generation and control of movement in humans.
Professor Christopher L. ‘Kit’ Vaughan is Emeritus Professor of Biomedical Engineering in the Department of Human Biology, University of Cape Town in South Africa. Kit Vaughan is considered a world authority on the biomechanics of human locomotion for which he was recognised with the award of a Doctor of Science in Medicine degree in 2009
INTERNATIONAL ADVISORY BOARD
31
Funding Partners
Our role in the scientific and medical communities is exemplified by the significant research funding the Trinity Centre for Bioengineering receives from national and international funding agencies including Science Foundation Ireland, Higher Education Authority, National Development Programme, Enterprise Ireland, Health Research Board, Irish Research Council and Wellcome Trust.
PARTNERS
Hospitals Academic Clinicians
Trinity Centre for Bioengineering
Industry
Research
Education
Outreach
Data analysis Academic
Collaborations
The Centre's researchers receive significant funding from national and international funding agencies, internationally recognized research accomplishments and awards
Concept to commercialisation
Innovative technology transfer
Prototyping
Laboratory bench tests
Flexible IP agreements
State of the art research facilities
Freedom to investigate new research/product areas
Clinical Trials
PARTNERS
32
Europe Academic Centre for Dentistry, Amsterdam (Netherlands) Aachen University, RWTH, Germany Czech Technical University (CTU) in Prague, Czech Republic Erasmus University, Rotterdam (Netherlands) Ghent University (UGent) together with Free University of Brussels (VUB), Brussels, Belgium Imperial College London (UK) Lund University Hospital (Sweden) Max Planck Institute for Biological Cybernetics Pasteur Research Institute (France) Politecnic of Bari (Italy) Sahlgrenska University Hospital (Sweden) TU / Eindhoven (Netherlands) Universitat Politècnica de Barcelona (Spain) University of Glasglow (UK) University of Groningen (RuG), Netherlands University of Newcastle (UK) University of Southampton (UK) University of Zaragoza (Spain) Utrecht University (The Netherlands)
USA
UC Berkeley City College of New York Columbia University The Nathan Kline Institute for Psychiatric Research, New York GeorgiaTech Harvard MIT Michigan Technological University Stanford University Cornell University Mount Sinai Medical Centre Albert Einstein School of Medicine Wake Forest University USA
Industry Integra Life Sciences Marigot Surgacoll Technologies Medtronic Boston Scientific Georgia Tech Intel Inc Siemens, Austria Vitalograph
Hospitals Beaumont Hospital Cappagh National Orthopaedic Hospital Mater Misericordiae Hospital National Rehabilitation Hospital The Adelaide and Meath Hospital, Dublin incorporating the National Children’s Hospital Santry Sports Clinic St. Patricks Hospital St. James’s Hospital St. Vincent’s University Hospital St. Vincent’s Hospital (Fairview) Waterford Regional Hospital Lund University Hospital Sweden Royal Victoria Eye & Ear Hospital
Academic Partners
Ireland Dublin City University IT Sligo NUI, Galway Queen’s University of Belfast Royal College of Surgeons in Ireland University College Cork University College Dublin University of Limerick University of Ulster National College of Art & Design
Australia University of Sydney University New South Wales
PARTNERS
33
PUBLICATIONS 2013 Ahearne, M., Liu, Y., Kelly, D.J. Combining freshly isolated chondroprogenitor cells from the infrapatellar fat pad with a growth factor delivery hydrogel as a putative single stage for articular cartilage repair. Tissue Engineering, Part A (in press). Sheedy, C.M., Power A.J., Reilly, R.B., Crosse, M.J., Loughnane, G.M., Lalor, E.C. Endogenous auditory frequency-based attention modulates obligatory sensory activity in humans. Neuroreport, in press. O'Sullivan, J.A., Power, A.J., Mesgarani, N., Rajaram, S., Slaney, M., Shinn-Cunningham, B.G., Shamma, S.A., Lalor, E.C. Attentional selection in a multi-speaker environment can be decoded from single-trial EEG. Cerebral Cortex, in press. Brennan, M.A..Gleeson, J.P.O’Brien, F.J.McNamara L.M Effects of ageing,prolonged estrogen
deficiency and zoledronate on bone tissue mineral distribution Journal of the Mechanical
Behavour of Biomedical Materials 29 (2014) 1 6 1 – 1 7 0
Takaza, M, Moerman K, Simms CK, “Passive Skeletal Muscle Response to Impact Loading:
Experimental testing and inverse modelling” in press JMBBM, April 2013.
Amato G, O'Brien F, Ghosh B, Simms CK, “Title: Multibody modelling of a TB31 and a TB32
crash test with vertical portable concrete barriers: Model verification and sensitivity analysis”
in press, IMechE Journal of Multibody Dynamics, March 2013.
Amato G, O’Brien F, Ghosh B, Williams, G, Simms CK, “Multibody modelling of gabion beams
for impact applications”, in press Journal of Crashworthiness, February 2013.
Gindre J, Takaza M, Moerman K, Simms CK, A Structural Model of Passive Skeletal Muscle
shows Two Reinforcement Processes in Resisting Deformation, in press JMBBM, February
2013.
Mesallati, T., Buckley, C.T., Kelly, D.J. A comparison of self-assembly and hydrogel
encapsulation as a means to engineer functional cartilaginous grafts using culture expanded
chondrocytes. Tissue Engineering, Part C (in press).
Steward, A.J., Wagner, D.R., Kelly, D.J. A role for integrin binding and microtubule
reorganization in mesenchymal stem cell mechanotransduction. Journal of the Mechanical
Behavior of Biomedical Materials (in press).
Thorpe, S.D., Nagel, T., Carroll, S.F., Kelly, D.J. Modulating gradients in regulatory signals within
mesenchymal stem cell seeded hydrogels: A novel strategy to engineer zonal articular
cartilage. PLoS One, 8(4): e60764, 2013.
Burke, D., Dishowitz, M., Sweetwyne, M., Miedel, E., Hankenson, K.D., Kelly, D.J. The role of
oxygen as a regulator of stem cell fate during fracture repair in tsp2-null mice. Journal of
Orthopaedic Research (in press).
O hEireamhoin*, S., Buckley, C.T.*, Jones, E., McGonagle, D., Mulhall, K.J. and Kelly, D.J.
Recapitulating aspects of the oxygen and substrate environment of the damaged joint milieu
for stem cell based cartilage tissue engineering. Tissue Engineering Part C, 19(2):117-27, 2013
* Both authors contributed equally to this study.
34
PUBLICATIONS 2013
Nagel, T., Kelly, D.J. Altering the swelling pressures within in vitro engineered cartilage is
predicted to modulate the configuration of the collagen network and hence improve tissue
mechanical properties. Journal of the Mechanical Behavior of Biomedical Materials (in press).
Liu, Y., Buckley, C.T., Mulhall, K.J., Kelly, D.J. Combining BMP-6, TGF-β3 and hydrostatic
pressure stimulation enhances the functional development of cartilage tissues engineered
using human infrapatellar fat pad derived stem cells. Biomaterials Science (in press).
Ahearne, M., Kelly, D.J. A comparison of fibrin, agarose and gellan gum hydrogels as carriers of
stem cells and growth factor delivery microspheres for cartilage regeneration. Biomedical
Materials (in press).
Cilla, M., Pena, E., Martınez, M.A., Kelly, D.J. Comparison of the vulnerability risk for positive
versus negative atheroma plaque morphology. Journal of Biomechanics (in press).
Cochlear implant artifact attenuation in late auditory evoked potentials: A single channel
approach Hearing Research, Volume 302, August 2013, Pages 84-95 Myles Mc Laughlin,
Alejandro Lopez Valdes, Richard B. Reilly, Fan-Gang Zeng
Science versus design; comparable, contrastive or conducive?
Journal of the Mechanical Behavior of Biomedical Materials, Volume 21, May 2013, Pages 195-
201
Gijsbertus J. Verkerke, Eduard B. van der Houwen, Anton A. Broekhuis, Jiri Bursa, Gerardo
Catapano, Paul McCullagh, Khosrow Mottaghy, Peter Niederer, Richard Reilly, Vladimir
Rogalewicz, Patrick Segers, Nico Verdonschot
K.M. Coghlan, L.T. Breen, Z. Martin, S. O'Neill, P. Madhaven, D. Moore, B.P. Murphy An
Experimental Study to Determine the Optimal Access Route for Renal Artery Interventions
European Journal of Vascular and Endovascular Surgery, Volume 46, Issue 2, August 2013,
Pages 236-241
Holland, J.C., Brennan, O., Kennedy, O.D., Mahony, N.J., Rackard, S., O'Brien, F.J., Lee,
T.C.Examination of osteoarthritis and subchondral bone alterations within the stifle joint of an
ovariectomised ovine model Journal of Anatomy 222 (6) , pp. 588-597
Raftery, R., O’Brien, F.J., Cryan, S-A. Chitosan for gene delivery and orthopedic tissue
engineering applications 2013 Molecules 18 (5) , pp. 5611-5647
Matsiko, A. Levingstone, T.J. O’Brien, F.J. Advanced strategies for articular cartilage defect
repair 2013 Materials 6 (2) , pp. 637-668
Amato G, O’Brien F, Ghosh B, Williams, G, Simms CK, “Multibody modelling of gabion beams
for impact applications”, in press Journal of Crashworthiness, February 2013.
35
PUBLICATIONS 2013
Kelly SP, Vanegas MI, Schroeder CE, Lalor EC. The cruciform model of striate generation of the early
VEP, re-illustrated, not revoked: A reply to Ales et al. (2013). Neuroimage. 2013 Jun 2;82C:154-159.
The cruciform model of striate generation of the early VEP, re-illustrated, not revoked: A reply to
Ales et al. (2013). Kelly SP, Vanegas MI, Schroeder CE, Lalor EC. Neuroimage. 2013 Jun 2;82C:154-
159.
Frey HP, Molholm S, Lalor EC, Russo NN, Foxe JJ Atypical cortical representation of peripheral visual
space in children with an autism spectrum disorder. Eur J Neurosci. 2013 Jul;38(1):2125-38.
Widaa,A. Brennan,O. O’Gorman, D.M. O’Brien, F.J. The osteogenic potential of the marine-derived
multi-mineral formula aquamin is enhanced by the presence of vitamin D 2013 Phytotherapy
Research Article in Press
Frey HP, Molholm S, Lalor EC, Russo NN, Foxe JJAtypical cortical representation of peripheral visual
space in children with an autism spectrum disorder.. Eur J Neurosci. 2013 Jul;38(1):2125-38.
McCoy, Ryan J. Orchestrating Osteogenic Differentiation of Mesenchymal Stem Cells – Identification
of Placental Growth Factor as a Mechanosensitive
Widaa, Amro Ph.D1, Watters, Karen M. Ph.D3, Wuerstle, Maximilian4, Stallings, Ray L. Gene with a
Pro-osteogenic Role Eng.D1,2. Ph.D3, Duffy, Garry P. Ph.D1,2, O’Brien, Fergal J. Ph.D1,2 STEM CELLS
Steward, A.J., Wagner, D.R., Kelly, D.J The pericellular environment regulates cytoskeletal
development and the differentiation of mesenchymal stem cells and determines their response to
hydrostatic pressure. European Cells and Materials, 25, 167-178, 2013.
Mesallati, T., Buckley, C.T., Nagel, T., Kelly, D.J. Scaffold architecture determines chondrocyte
response to externally applied dynamic compression. Biomechanics and Modeling in
Mechanobiology (in press).
Sheehy, E., Vinardell, T., Buckley, C.T., Kelly, D.J. Engineering osteochondral constructs through
spatial regulation of endochondral ossification. Acta Biomaterialia, 9(3):5484-92, 2013.
Nagel, T., Kelly, D.J. The composition of engineered cartilage at the time of implantation determines
the likelihood of regenerating tissue with a normal collagen architecture. Tissue Engineering Part A
(in press).
Haugh, M.G., Thorpe, S.D., Vinardell, T., Duffy, G.P. and Kelly, D.J. The application of plastic
compression to modulate fibrin hydrogel mechanical properties. Journal of the Mechanical Behavior
of Biomedical Materials, 16:66-72, 2012.
McLaughlin M., Reilly R.B., Zeng FG, “Sound source segregation cues improve cochlear implant
vowel recognition in noise”, Journal of the Acoustic Society of America, MS #11-11239, in press.
McLaughlin M., Lopez Valdes A, Reilly, R.B., Zeng, F-G, “Cochlear Implant Artifact Attenuation in Late
Auditory Evoked Potentials: A Single Channel Approach”, Hearing Research, in press
36
Verkerke G.J., Van der Houwen J., Broekhuis A.A., Bursa J., Catapano G., McCullagh P., Mottaghy
K.,Niederer P., Reilly R., Rogalewicz V., Segers P., Verdonschot N. “Science versus Design; comparable,
contrastive or conducive?”, J Mech Behaviour of Biomed Materials, in press
Hutchinson M., Kimmich, O., Molloy, A., Whelan, R., Molloy, F., Lynch, T., Healy, D., Walsh, C.,
Edwards, M., Ozelius, L., Reilly, R., O'Riordan, S., The mediational endophenotype is mightier than the
phenotype: temporal discrimination in dystonia”, Movement Disorders - Manuscript # MDS-12-1359,
in press.
Ó Donnchadh S, Burke T., Bramham J., O’Brien M.C., Whelan R., Reilly R.B., Kiiski K., Lonergan R.,
Kinsella K., Kelly S., McGuigan C., Hutchinson M., Tubridy N “Symptom overlap in anxiety and multiple
sclerosis”, Multiple Sclerosis Journal, Manuscript ID is MSJ-12-0808, in press.
Mulroy E, Quigley G, Roberts K, Cummins G, Magennis B, Fortune G, O'Brien D, Blunnie WP,
Harrington E, Gillivan-Murphy P, Kavanagh E, Gilligan P, Reilly R, Scolaí PO, Kelly S, Murray M, Lynch
T, “Deep brain stimulation in Ireland for Parkinson's disease and essential tremor”, Irish Journal of
Medical Science, 2012 Sep;105(8):278-80. PMID: 23155918.
Lochlainn M., Gubbins S., Connolly S., Reilly R.B., “The vegetative and minimally conscious states: a
review of the literature and preliminary survey of prevalence in Ireland”, Irish Journal of Medical
Science, 2012 Apr 24. PMID: 22528253.
Gindre J, Takaza M, Moerman K, Simms CK, A Structural Model of Passive Skeletal Muscle shows Two
Reinforcement Processes in Resisting Deformation, in press JMBBM, February 2013.
Moore M, Simms CK, Hennessy D, Hanly A, Winter D, Laparoscopic Wound Closure Techniques: A
Review of Current Practice and Proposed Patents, Recent Advances and Research Updates, Vol 13, no
1, pp 109-115.
Amato G, O’Brien F, Ghosh B, Williams, G, Simms CK, A Scaling Method for Modelling the
Crashworthiness of Novel Roadside Barrier, in press, Journal of Crashworthiness, October 2012.
Lyons M, Winter D, Simms CK, Ventral hernia: Extrusion properties of porcine intestines and
surrogate materials, in press JMBBM, October 2012.
Matsiko A, Levingstone T, O’Brien F.J., Advanced Strategies for Artciular Cartilage Defect Repair,
published 22 February 2013 Materials doi: 10.3390/ma6020637
Claro T, Widaa A., McDonnell C., Foster T., O’Brien FJ., Kerrigan S. Staphylococcus aureus protein A
binding to osteoblast tumour necrosis factor receptor 1results in activation of nuclear factor kappa B
and release of interleukin-6 in bone infection Microbiology (2013), 159, 147–154
Tierney E, McSorley K, Hastings C, Cryan SA, O'Brien T, Murphy M, BarryF, O'Brien F, Duffy G. High
levels of ephrinB2 over-expression increases the osteogenic differentiation of human mesenchymal
stem cells and promotes enhanced cell mediated mineralisation in a polyethyleneimine-ephrinB2
gene-activated matrix
PUBLICATIONS 2013